The ONLY Safety Trainings that will be held this quarter will be: NEW STUDENTS: Monday, Sept. 29th,...
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Transcript of The ONLY Safety Trainings that will be held this quarter will be: NEW STUDENTS: Monday, Sept. 29th,...
The ONLY Safety Trainings that will be held this quarter will be:
NEW STUDENTS: Monday, Sept. 29th, 5:30PM -7:30PM in CB270 REFRESHING STUDENTS: Wed., Oct. 1st, 5:30 PM - 6:30PM in CB270 Please reply NOW if you have a time conflict. Refreshments will be served. You must sign up in advance. Sign up sheets are in the main office.
ALL students working in the research and teaching labs in the Chemistry Department must complete safety training ANNUALLY (includes student employees, those in research credit courses, and volunteers). On-line and organic safety quizzes do not count.
Fall Quarter 2003 Chem/Biol 471 BioChemistry
• Instructor: Gerry Prody
• Office CB444– Office hrs: M 12-1:30 pm and W 2-3:30 pm– You can also find me TR 11-2 in CB 210.
• Course web site: http://lightning.chem.wwu.edu/dept/facstaff/ prody/prody-471.htm
What is Biochemistry?
• the systematic torture of students with copious incomprehensible jargon, cryptic fomulae, and impossible insoluble problems.
“Biochemistry is the study of Life as a process that can be understood.”
Primary Objective: understand the molecular mechanisms that constitute the living state (“Molecular Logic”)
Apply Biochemical Understanding to:
• advances in medicine and healthcare (gene therapy,
biopharmaceuticals, diagnostics)
• agricultural practices
• biological responses to environmental signals(chemical toxicity, hormone action)
(crop protection, animal husbandry)
How Does Science Describe the Living State?
• Organisms must extract energy from their environment
• Ability to adapt to change
• Possess ability to self-replicate and self-assemble
Lehninger: “Molecular Logic”“A living cell is a self-assembling, self-regulating, self-replicating isothermal open system of organic molecules operating on a principle of maximum economy of parts and processes; it promotes many consecutive, linked organic reactions for the transfer of energy and for the synthesis of its own components by means of organic catalysts that it produces itself.”
Biol/Chem 471; Biol/Chem 472 ; Biol/Chem 473
smaller organicmolecules
How does science describethe living state?
Biopolymers/Macromolecules
atoms, subatomicparticles…the undiscovered
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Figure 1-14 Example of the hierarchical organization ofbiological structures.
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Figure 1-2 Schematic drawing of a prokaryotic cell.
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Figure 1-13 Simulated cross section of an E. coli cellmagnified around one millionfold.
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Figure 1-4 Phylogenetic tree.
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Figure 1-10 Drawings of some human cells.
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Figure 1-5 Schematic diagram of an animal cellaccompanied by electron micrographs of its organelles.
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Figure 1-9 Drawing of a plant cell accompanied byelectron micrographs of its organelles.
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Figure 1-15 Polymeric organization of proteins, nucleicacids, and polysaccarides.
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Figure 1-37 Apparatus for emulating the synthesis of organic compounds on the
prebiotic Earth.
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Examples: Calculate the pH for a solution of 0.2 M HCl.
Add 10 mL of this solution to 50 mL of 0.2 M NaAc (pK=4.7). Now what is the pH?
How could you prepare 2 L of a solution of sodium acetatepH=5.
In what pH range is acetate a “good” buffer?
Figure 2-4 Theoretically predicted and spectroscopically
confirmed structures of the water trimer, tetramer, and pentamer.
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Figure 2-10 Acid-base titration curves of 1-L solutions of 1M acetic acid, H2PO4
–, and NH4
+ by a strong base.
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Table 2-1 Dielectric Constants and Permanent Molecular Dipole
Moments of Some Common Solvents.
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Table 2-3 (top) Dissociation Constants and pK’s at 25°C of
Some Acids in Common Laboratory Use as Biochemical
Buffers.
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