The Measurable Difference Prepared for U.S. Aim High Conferences, 2004.
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Transcript of The Measurable Difference Prepared for U.S. Aim High Conferences, 2004.
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The Measurable Difference
Prepared for U.S. Aim High Conferences, 2004
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What is LifePak®?
A comprehensive nutritional wellness program delivering the optimum amounts of all essential and generally beneficial nutrients for long-term health and well-being.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Comprehensive & Convenient
>Multi
VitaminVitamin E
300 IU
Calcium &Magnesium
Chromium200 mcg
MultiCarotenes
Vitamin C500 mg
MultiFlavonoid
Better than these 7 popular supplements together.
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LifePak® Health BenefitsOptimum supplementation for general well-being*1. Addresses nutrient deficiencies*2. Cardiovascular benefits*3. Complete bone nutrition*4. Promotes healthy immune function*5. Supports normal blood sugar metabolism*6. Protects against the symptoms of aging*
7. Raises your antioxidant defense**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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The Need to Supplement
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“… low levels of the antioxidant vitamins (vitamins A, E, and C) may increase risk for several chronic diseases. Most people do not consume an optimal amount of all vitamins by diet alone.”
“It appears prudent for all adults to take vitamin supplements.”
Journal of the American Medical Association June 2002
Robert H. Fletcher, MD, MSc; Kathleen M. Fairfield, MD, DrPH, Harvard UniversityJournal of the American Medical Association 2002; 287: 3127-3129
A Landmark Endorsement
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Free Radicals• Highly reactive, short-lived molecules• Damage cells and genetic material (DNA)
• 70,000 free radical attacks on DNA every day in a cell• Aging process• Implicated in most health conditions• Many different types of free radicals
Free Radicals & Antioxidants
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Sources of Free Radicals
• Environmental pollution (smog, ozone, NO2) • Radiation exposure:
– sunlight (UV-light), X-rays, etc.• Smoking:
– 10,000,000,000,000,000 free radicals/cigarette!
• Metabolism in your mitochondria
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Antioxidants fight free radicals• Slow down aging process & improve health:
• over 30,000 research studies on antioxidant health benefits• affecting over 50 health conditions, including cardiovascular
function, eye health, CNS health, skin health, etc.
• Many antioxidants work together: “Antioxidant Defense System”
• Relies on a steady supply of dietary antioxidants
Free Radicals & Antioxidants
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LifePak® 40+ Antioxidants
• All 8 forms of natural vitamin E: 300 IU• Buffered vitamin C: 500 mg• Selenium, Copper, Zinc, Manganese• 6 Carotenoids:
– as found in 5-10 fruits & vegetables per day • Over 20 Flavonoids:
– 6 Catechins, Quercetin, naringenin, hesperidin, 3 Soy isoflavones, Over 10 grape seed polyphenols
• Alpha-Lipoic Acid: 30-50 mg
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LifePak® Science is Measurable
• First to show antioxidant and cardiovascular benefits in double-blind studies*
• 200,000+ published studies on LifePak’s antioxidants
• Nearly 800,000 published studies on all LifePak ingredients
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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LifePak® Clinical StudyAntioxidant and Cardiovascular Health*
42.1 42
43.4
50.9
30
35
40
45
50
55
60
65
Baseline Endpoint
PlaceboLifePak
p < 0.001
331299
335
716
0
200
400
600
800
1000
1200
Baseline Endpoint
PlaceboLifePak
p < 0.001
3.4773.429
6.248
3.305
0
1
2
3
4
5
6
7
8
Baseline Endpoint
PlaceboLifePak
p < 0.001
Smidt CR, Seidehamel RJ, Devaraj S, Jialal I. FASEB Journal Vol.13 No.4, p.A546, March 1999.
LDL Protection*
Vitamin E
Beta-carotene
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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LifePak® Antioxidant Capacity (ORAC)Jan 2003
0
500
1000
1500
2000
2500
3000
3500
MM
-1
MLM
-A
MLM
-B
MLM
-CM
M-2
MLM
-D
MLM
-E
LifePak
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Pharmanex® BioPhotonic Scanner
• LifePak® augments the entire antioxidant defense system*
• The effect can easily be demonstrated using the BioPhotonic Scanner
• Clinical studies identify link between scores and healthy diet and lifestyle
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Function and Structure of Carotenoids
• uptake through the diet• safe vitamin A sources (a- & b-carotene)• antioxidants (1O2 quenchers)• promote immune function (b-carotene)• protect cellular DNA (lycopene)• protect macular region of retina (lutein)
Lycopene
-carotene
-carotene
Zeaxanthin
Lutein
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Biological Functions of Carotenoids
Color of the beak is signal female zebra finches consider when selecting a mate; clear now that a male's carotenoid levels, and therefore attractiveness, are linked to the effectiveness of his immune function.
Bright beaks in birds signal health of the immune system
Source: Pennisi, E. 2003. Colorful males flaunt their health. Science 300: 29-30
Zebra finch
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SpectrometerAn instrument that separates light signals into different frequencies, producing a spectrum
What is a Spectrometer?
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Vibronic Energy Levels
Laser light
Raman scattered light
Excited Carotenoid molecules shift blue laser light color from blue to green
What is Raman Spectroscopy?
“Raman” effectA scattering of electromagnetic radiation through a transparent medium in which light changes in frequency (color)
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Scanner Science is Measurable• National Institutes of Health and Office of Dietary Supplements• New York Academy of Sciences• Oxygen Club of California• FASEB/American Physiological Society - Oct 2003 and April
2004• Gordon Research Conference• Review paper pending publication in Current Topics in
Nutraceutical Research
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Demographic Study - Sep 2002
0
20
40
60
80
100
120
1000
4000
7000
1000
0
1300
0
1600
0
1900
0
2200
0
2500
0
2800
0
3100
0
3400
0
3700
0
4000
0
4300
0
4600
0
4900
0
5200
0
5500
0
5800
0
6100
0
6400
0
6700
0
7000
0
7300
0
7600
0
7900
0
BDS Categories
Fre
qu
ency 1st
5th10th
25th50th
75th90th 95th 99th
Percentile Rankings: 1st 4,500 5th 8,500 10th 10,500 25th 13,500 50th 17,500 75th 22,500 90th 30,500 95th 36,500 99th 48,000
Mean: 19,072SD: 8,828
1,375 Subjects
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1,375-Subject Study
Results show that Skin Carotenoid Signal:
• Is not influenced by Age, gender or skin pigmentation (race/ethnicity)
• Is high in people who eat more fruits & vegetables
• Is high in people who take LifePak*• Is low in people who smoke or have
oxidative stress (free radical damage)
Demographic Study
16827
19669
2537723997
0
5000
10000
15000
20000
25000
30000
1 or Less 2 to 3 4 to 5 6 or More
Reported Daily Fruit & Vegetable Servings
Ram
an
In
ten
sit
y, C
ou
nts
.
n = 534 n = 649 n = 137 n = 30
p < 0.01 p < 0.01
17888
20193
25717
28848
0
5000
10000
15000
20000
25000
30000
35000
None Irregular One/Day Two/Day
Reported LifePak Usage
Ram
an
In
ten
sit
y, C
ou
nts
.
n = 59n = 89n = 192n = 800
p < 0.01
p < 0.01
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Clinical Study - Sep 2002 LifePak® Scanner Score*
32175
25991
28924
18828
10000
15000
20000
25000
30000
35000
40000
0 4 8 12Time (Weeks)
Ram
an
In
ten
sit
y, C
ou
nts
.
p < 0.001
p < 0.01
p = 0.23
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Body Fat - Inverse Correlation
0
5000
10000
15000
20000
25000
30000
Normal Overweight Obese Morbidly Obese
Body Mass Index (BMI)
Ra
ma
n I
nte
ns
ity
(m
ea
n)
(N = 131,122 scans)
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Antioxidant Status and Weight Loss
1. Overweight and obesity are associated with decreased antioxidant protection.
2. Dieting causes stress to the body, generating more free radicals, which may result in decreased antioxidant protection.
ConclusionOverweight individuals and anyone on a diet should increase antioxidant protection through diet and supplementation.
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Carotenoid Correlation Study June 2003
0
10,000
20,000
30,000
40,000
50,000
60,000
0.0 1.0 2.0 3.0 4.0
Total Serum Carotenoids (mg/ml)
Ra
ma
n In
ten
sit
y C
ou
nts
r = 0.78 p < 0.001
Pending publication, FASEB April 2004
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Scan Values in Asians Singapore study - Dec 2003 Thailand study - Jan 2004 Same data relationship as U.S.
study (diet, supplements, body fat, lifestyle)
25,000 average with 82% of participants taking LifePak®
LifePak® users (2/day) scored 25% higher than non-LP users*
20,000
22,000
24,000
26,000
28,000
LifePak 2/dayLifePak 1/dayno Lifepak
Internal data on file. *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Summary of Scanner Research
Data from 300,000 scans and Asian studies correlate with original demographic study of 1,300 participants
Known risk factors that induce oxidative stress reduce scanner score
Healthy diets improves score Long-term LifePak® supplementation improves score* Score is related to lean body mass & body fat Desirable score is the blue zone, the higher the better
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Media Coverage in 2003Self Magazine April 03
Elle Magazine Sep 03
Ms. Fitness Magazine Oct 03
NBC Today in LA
KNXV ABC News
Phoenix AZ News 3
WHDH-TV NBC Boston MA
WHAS 11 News Louisville KY
News All Morning New York
KUTV News Salt Lake City
NewsChannel 4 Columbus OH
CNBC Asia - Singapore
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The QuestionsHow Does Measuring Skin Carotenoids Predict Antioxidant Status?
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VITAMIN CcycleVITAMIN E
cycle
THIOLcycle
NAD(P)H + H+
NAD(P)+
Lipid–water interface
ROOHROH
PUFA
O2– and other radicals
Metabolism, strenuous exercise,cigarette smoke, pollution
ROO•RO•
The Antioxidant Network
Carotenoids
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The QuestionsWhat Does “25,000” Mean?
16827
19669
2537723997
0
5000
10000
15000
20000
25000
30000
1 or Less 2 to 3 4 to 5 6 or More
Fruit & Vegetable Servings
Skin
Caro
ten
oid
Sco
re
n = 534 n = 649 n = 137 n = 30
p < 0.01 p < 0.01
• Serum equivalent ~ 1 mcg/ml (+ 10%, 95% CI)
1000 units ~ 0.04 mcg/ml• ~ 5 servings fruits/veg. per day
Average Diet• 2-3 fruits/veg.• Scan 19,000 • 0.7 mcg/ml serum
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How Can I Improve My Score?
10,000
20,000
30,000
40,000
50,000
High
Moderate to High
Moderate
Low
• Moderate fruit/veg. intake
• Irregular supplement use
• Smoker
• High body fat
(i.e. s
moking)
SCS = 20,000
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The QuestionsHow Can I Improve My Score?
10,000
20,000
30,000
40,000
50,000
High
Moderate to High
Moderate
Low
SCS = 42,000
• Take LifePak® 2x/day
• Improve diet
• Quit smoking
• Lose weight
(i.e. s
moking)
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Live Better, Longer
Rei
shiM
ax®
TRA
Com
plex
™
IgG
Boo
st™
Cor
dyM
ax®
Cor
titro
l™
LifePak® Family
MarineOmega™
Optimal Health
Free Radical Protection - Pharmanex® BioPhotonic Scanner
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