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Titre du document / Document titleThe influence of retinopathy of prematurity on ocular growth

Auteur(s) / Author(s)KENT D. (1 2) ; PENNIE F. (1 2) ; LAWS D. (3) ; WHITE S. (4) ; CLARK D. (1 2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)(1) Eye Department, University Hospital Aintree, Liverpool L9 1AE, ROYAUME-UNI(2) Neonatal Unit, Liverpool Women's Hospital, Liverpool L8 7SS, ROYAUME-UNI(3) Department of Ophthalmology, Singleton Hospital, Sketty, Swansea SA2 8QA, ROYAUME-UNI(4) R&D Support Unit, Aintree Hospitals NHS Trust, Liverpool L9 7AL, ROYAUME-UNI

Rsum / AbstractPurpose Retinopathy of prematurity (ROP) stage 3 eyes that require treatment have a greatertendency to myopia compared with eyes with mild ROP. As the mechanisms controlling this myopiaare as yet ill understood, we undertook this study to investigate what effect the initial stage of ROPand modality of treatment had on ocular growth. Methods Eighty-five children were assessed. Allchildren were refracted and underwent 'through-the-lid' biometry using the Zeiss Humphreybiometer 820. The printout obtained was then recorded on video so that the scan could be capturedon computer for formal calibration and measurement by a masked observer. Differences in thedistribution of variables between the stages of ROP were analysed by one-way analysis of

variance, non-parametric Kruskal-Wallis one-way analysis of variance or Mann-Whitney U-test asappropriate. Results A difference between the stages of ROP was apparent only for posteriorsegment length (PSL) (R: p = 0.03; L: p = 0.05) and a borderline difference for anterior chamberdepth (ACD) (R: p = 0.06; L: p = 0.06). However, if stage 3 was divided into categories of treatedand untreated, axial length (AL) achieved borderline significance (R: p = 0.07; L: p = 0.05) but withno difference between laser-treated and the other stages for AL. Lens thickness (LT) also appearsto be influenced by type of treatment (R: p = 0.06; L: p = 0.13). Myopia was associated with stage 3(R + L: p = 0.0001) and if stage 3 was subdivided the significance was maintained only for thelaser- and cryotherapy-treated eyes. Conclusions Laser-treated eyes were less myopic than thosetreated with cryotherapy. AL does not explain all the myopia found in stage 3 treated eyes. Thestudy confirms the tendency towards anterior segment arrest in stage 3 ROP.

Revue / Journal TitleEye (Eye) ISSN 0950-222X CODEN EYEEEC

Source / Source

CongrsRoyal College of Ophthalamologists Annual Congress , ROYAUME-UNI (1998)Irish College of Ophthalmologists Annual Meeting , INCONNU (1998)2000, vol. 14 (1), pp. 23-29 (29 ref.)

Langue / LanguageAnglais

Editeur / PublisherNature Publishing Group, Basingstoke, ROYAUME-UNI (1987) (Revue)

Mots-cls anglais / English KeywordsRetinopathy ; Premature ; Clinical stage ; Myopia ; Risk factor ; Eye ; Laser ; Cryotherapy ;Treatment ; Development ; Anterior segment ; Eye disease ; Vision disorder ; Refractive error ;

Mots-cls franais / French Keywords

Rtinopathie ; Prmatur ; Stade clinique ; Myopie ; Facteur risque ; Oeil ; Laser ; Cryothrapie ;Traitement ; Dveloppement ; Segment antrieur ; Oeil pathologie ; Trouble vision ; Troublerfraction oculaire ;

002b09i ;

Mots-cls espagnols / Spanish KeywordsRetinopata ; Prematuro ; Estadio clnico ; Miopa ; Factor riesgo ; Ojo ; Laser ; Crioterapia ;Tratamiento ; Desarrollo ; Segmento anterior ; Ojo patologa ; Trastorno visin ; Trastornorefraccin ocular ;

Localisation / LocationINIST-CNRS, Cote INIST : 21076, 35400008665045.0050

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