The inferior olivary nucleus is the only source of cerebellar climbing fibers Introduction to...
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![Page 1: The inferior olivary nucleus is the only source of cerebellar climbing fibers Introduction to Neurobiology Lecture 10: The inferior olive 1.](https://reader031.fdocuments.us/reader031/viewer/2022032801/56649d535503460f94a2fab2/html5/thumbnails/1.jpg)
The inferior olivary nucleus is the only source of cerebellar climbing fibers
Introduction to NeurobiologyLecture 10: The inferior olive 1
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The Inferior Olive nucleus 2
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Olivary neurons (Ramon Y Cajal)
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Intracellular labeling of olivary neuron HRP filled olivary neuron4
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Action potential in olivary neuron5
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Action potentials in olivary neuron6
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The effect of TTX on action potentials in olivary neuron7
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The effect of Mn2+ and Cd2+ on action potentials in olivary neuron 8
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-68 mV
-60 mV
-60 mV
-55 mV
Two types of action potentials in olivary neuron
20 msec
1 nA
15 mV 15 mV
-60 mV
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The Na+ and Ca2+ components of the two types of action potentials
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TTX
Independent activation of the action potentials 11
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Refractory period of the action potentials 12
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10 mV
Refractory period of the action potentials 13
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The Inactivation curve of the low threshold action potential14
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The effect of Harmaline on Olivary neuron . 15
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The effect of harmaline on the Inactivation curve .
control
harmaline
control
harmaline
Resting potential
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The effect of Octanol on Olivary neuron . 17
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Possible mechanism of rhythmic activity
Ionic currents in Olivary neurons:
Na current – typical H&H current
Dendritic Ca current – high threshold non-inactivating
Ca dependent, K current
Somatic Ca current – low threshold inactivating
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Cell 1 Cell 2
Cell 1
Cell 2
10 mV
5
200 ms
10 mV
20 mV
Cell 1
Cell 25
mV
200 ms
Cell 1
Cell 22
mV
100 ms
20 mV
Electrical coupling between olivary neuron 19
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Dye coupling between olivary neuron 20
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The olivary glumerulus 21
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Olivary Gap junction 22