The Importance of Trauma in Traumatic Brain Injuryjoelsd/capstone/Capstone 2020.pdfThe Importance of...
Transcript of The Importance of Trauma in Traumatic Brain Injuryjoelsd/capstone/Capstone 2020.pdfThe Importance of...
The Importance of Trauma in Traumatic Brain Injury
The Injury Event Dictates Injury Outcome
Bryan Pfister, PhDProfessor and Chair, Biomedical Engineering
Associate Director, Center for Injury Biomechanics, Materials and Medicine
Namas Chandra, DirectorBryan Pfister, Assoc. Director
Thanks to colleagues/students and funding agenciesThanks to millions of soldiers who guard our freedom
In Vitro Model – Stretch InjuryShock Tubes - Blast Injury
Drop Tower- Blunt InjuryAnimal Models
Unique Facilities
Peak
Rise time
Traumatic Brain Injury
Blunt Injury
Inertial LoadingDiffuse Injury
BlastInjury
Margulies et. al. 1990
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Mechanics of TBI• Head rotations lead
to significant shear deformations of brain tissue.
• Bulk shearing often translates to a localized stretching of individual neurons and their processes.
Magou et.al. 2011 J NeurotraumaSmith and Meaney 2000 NeuroscientistMeaney et.al. 1995 J Neurotrauma
DAIDiffuse Axonal Injury
Widespread injuryto axons.
Stretch leads to cellular damage.
Traumatic Axonal Stretch Injury
mTBIRepair
orDysfunction?Smith and Meaney 2000 Neuroscientist
In Vitro TBI Model Traumatic Axonal Stretch Injury
Magou et.al. 2011 J Neurotrauma
What type of loading and tissue deformation is realistic?
Concussion / Blunt Head Injury Modeling
Human Scale Model
(PMHS)
Impactor• Interchangeable body• Variable impact speed 3mph 5mph
Skull-Brain-Neck Surrogate• PVC human skull• 20% ballistic gel with markers• Hybrid III anthropomorphic neck• Adjustable impact orientation Crown Front
Blunt Injury Experimental Setup
Impact Direction Affects Deformation
Analysis: Motion tracking and strain computations
Shear strain - 3mph impact
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ε1 ε2 γmax
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Contour maps of mean maximum strains
Contour maps of strain rates associated with maximum strainsData displayed is for 5mph impacts
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ε1 ε2 γmax. . .
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~30%
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1 second long video
Different Rates of Deformation
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Modeling Variations in Injury
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Credits
Grant SupportNIH-NINDS
National Science FoundationNew Jersey Commission on Brain injury Research
In vitro modeling:Joshua Berlin
------Alexandra Adams
George ‘Dino’ Magou
In vivo modeling:Viji Santhakumar
Kevin Pang------
Mathew LongAswati ArvindEric Neuberger
Human surrogate modeling:Abdus Ali
Michael HannaBrian Swenson
Blast Injury:Namas ChandraMaciej Skotak
Rama Rao