The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.
-
Upload
julianna-pitts -
Category
Documents
-
view
216 -
download
0
Transcript of The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.
![Page 1: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/1.jpg)
The Immune System
memory and specificity
Chapter 43http://www.cellsalive.com/antibody.htmhttp://inet.uni2.dk/~iirrh/IIRhome.htm
![Page 2: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/2.jpg)
Topics in Immunity• Allergies:--plasma cells, immunoglobulins, and mast cells
--antibodies and antigens
• HIV-AIDS-- infection of T cells-- place of T cells in the immune system
• distinguishing self from non-self
![Page 3: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/3.jpg)
© Dennis Kunkel
One of the culprits: ragweed pollen
![Page 4: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/4.jpg)
Figure 42.14x Blood smear
![Page 5: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/5.jpg)
Figures 42.15 & 16 Types and Differentiation of blood cells
![Page 6: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/6.jpg)
Figure 43.8a,b The structure of a typical antibody molecule
![Page 7: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/7.jpg)
Table 43.1 The Five Classes of Immunoglobulins
![Page 8: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/8.jpg)
Figure 43.16 Effector mechanisms of humoral immunity
![Page 9: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/9.jpg)
Figure 43.12 Clonal selection of B cells
![Page 10: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/10.jpg)
Timing of primary and secondary immune response
![Page 11: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/11.jpg)
pollen (the allergen) stimulates histamine release from mast cells
![Page 12: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/12.jpg)
Figure 43.18 Mast cells, IgE, and the allergic response
![Page 13: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/13.jpg)
Figure 43.14 An overview of the acquired immune responses 2
![Page 14: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/14.jpg)
Topics in Immunity• Allergies:--plasma cells, immunoglobulins, and mast cells
--antibodies and antigens
• HIV-AIDS-- infection of T cells-- place of T cells in the immune system
• distinguishing self from non-self
![Page 15: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/15.jpg)
Figure 42.14x Blood smear
![Page 16: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/16.jpg)
Figures 42.15 & 16 Types and Differentiation of blood cells
![Page 17: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/17.jpg)
Figure 43.9 The interaction of T cells with MHC molecules
![Page 18: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/18.jpg)
Structure and positioning of the Major histo-compatibility complex (MHC) proteins
Class I Class II
![Page 19: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/19.jpg)
Interaction of an MHC protein with its antigen
Class I
![Page 20: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/20.jpg)
Cytotoxic T cell action (FIG. 43.16)
![Page 21: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/21.jpg)
Clonal selection of Helper T cells and Cytotoxic T cells (FIG. 43.15)
![Page 22: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/22.jpg)
Figure 43.14 An overview of the acquired immune responses 1
![Page 23: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/23.jpg)
Figure 43.14 An overview of the acquired immune responses 2
![Page 24: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/24.jpg)
Figure 43.14 An overview of the acquired immune responses 2
![Page 25: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/25.jpg)
Figure 43.14 An overview of the acquired immune responses 3
![Page 26: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/26.jpg)
Presenting antigens: CD4 helps stabilize the connection.
(usually a macrophage)
![Page 27: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/27.jpg)
Figure 43.19 A T cell infected with HIV
![Page 28: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/28.jpg)
Figure 43.19x1 HIV on a lymphocyte, detail
![Page 29: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/29.jpg)
Figure 18.7 HIV, a retrovirus
![Page 30: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/30.jpg)
Figure 43.19x2 HIV budding
![Page 31: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/31.jpg)
Figure 43.20 The stages of HIV infection
![Page 32: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/32.jpg)
Only cells with both CD4 proteins and chemokine receptor proteins (CXCR4, CCR5) are vulnerable to the HIV virus.
These are the central cells in the immune system.
![Page 33: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/33.jpg)
![Page 34: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/34.jpg)
Figure 43.14 An overview of the acquired immune responses 3
![Page 35: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/35.jpg)
Figure 43.14 Epitopes (antigenic determinants)
![Page 36: The Immune System memory and specificity Chapter 43 iirrh/IIRhome.htm.](https://reader030.fdocuments.us/reader030/viewer/2022032708/56649e5d5503460f94b55b91/html5/thumbnails/36.jpg)
Topics in Immunity• Allergies:--plasma cells, immunoglobulins, and mast cells
--antibodies and antigens
• HIV-AIDS-- infection of T cells-- place of T cells in the immune system
• distinguishing self from non-self