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The IASLC Lung Cancer Database Summary of Cases Contributed to Project Total cases submitted 100,869 Excluded from analyses Excluded from analyses19,854 Outside of 1990-2000 time frame Outside of 1990-2000 time frame5,443 Incomplete survival data Incomplete survival data1,505 Unknown histology Unknown histology2,468 Incomplete stage information Incomplete stage information7,720 Recurrent cases and other exclusions Recurrent cases and other exclusions1,603 Carcinoids, sarcomas and other histologies Carcinoids, sarcomas and other histologies1,115 Included in analyses 81,015 Small Cell Lung Cancer (and mixed SCLC/NSCLC)Small Cell Lung Cancer (and mixed SCLC/NSCLC)13,290 Non-Small Cell Lung CancerNon-Small Cell Lung Cancer67,725 Updated from: Goldstraw P, Crowley JJ. The International Association for the Study of Lung Cancer International staging project on lung cancer. J Thorac Oncol 2006; 1: 281-286. Slide 2 The IASLC Lung Cancer Database Treatment Modalities 81,495 Cases Surgery36% Chemotherapy21%RT11% Surgery + Chemo 4% Surgery + RT 4% Chemo 12% Surgery + Chemo + RT 3% No treatment details or best supportive care: 10% From: Goldstraw P, Crowley JJ. The International Association for the Study of Lung Cancer International staging project on lung cancer. J Thorac Oncol 2006; 1: 281-286. Slide 3 The IASLC Lung Cancer Database Types of Contributing Groups 81,495 Cases Slide 4 The IASLC Lung Cancer Database Stage Distribution, Non-small Cell Lung Cancer 67,725 Cases with Clinical Stage, Pathological Stage, or Both Slide 5 The IASLC Lung Cancer Database Clinical Stage Distribution by Continent, Non-small Cell Lung Cancer 53,646 Cases 58% 7%21%14% Percent of total cases contributed with clinical stage From: Goldstraw P, Crowley JJ. The International Association for the Study of Lung Cancer International staging project on lung cancer. J Thorac Oncol 2006; 1: 281-286. Slide 6 The IASLC Lung Cancer Database Pathological Stage Distribution by Continent, Non-small Cell Lung Cancer 33,933 Cases Percent of total cases contributed with pathologic stage 51%7%13%28% Slide 7 The IASLC Lung Cancer Database Stage Distribution by Continent, Small Cell Lung Cancer 13,290 Cases (58%) (6%) (34%)(2%) Percent of total small cell cases contributed From: Goldstraw P, Crowley JJ. The International Association for the Study of Lung Cancer International staging project on lung cancer. J Thorac Oncol 2006; 1: 281-286. Slide 8 T-Descriptors Size of Primary Tumor Best Split for Tumor Size, pT1 Cases From: Rami-Porta R, Ball D, Crowley J et al. The IASLC lung cancer staging project: proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol 2007; 2: 593-602. Slide 9 T-Descriptors Size of Primary Tumor Best Split for Tumor Size, pT2 Cases 7.3 cm From: Rami-Porta R, Ball D, Crowley J et al. The IASLC lung cancer staging project: proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol 2007; 2: 593-602 Slide 10 Size of Primary Tumor, pT1-3, N0 NSCLC T-Descriptors Size of Primary Tumor From: Rami-Porta R, Ball D, Crowley J et al. The IASLC lung cancer staging project: proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol 2007; 2: 593-602 Slide 11 Size of Primary Tumor, cT1-3, N0 NSCLC T-Descriptors Size of Primary Tumor From: Rami-Porta R, Ball D, Crowley J et al. The IASLC lung cancer staging project: proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol 2007; 2: 593-602. Slide 12 T-Descriptors - Validation Size of Primary Tumor T1-3 N0 NSCLC United States National Cancer Institute SEER Registries From: Groome PA, Bolejack V, Crowley JJ et al. The IASLC lung cancer project: validation of the proposals for revision of the T, N, and M descriptors and consequent stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol 2007; 2: 694-705 Slide 13 Pathological T3/T4 M1 NSCLC T-Descriptors Additional Nodules and Pleural Dissemination From: Rami-Porta R, Ball D, Crowley J et al. The IASLC lung cancer staging project: proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol 2007; 2: 593-602. Slide 14 T-Descriptors Additional Nodules and Pleural Dissemination Clinical T3/T4 M1 NSCLC From: Rami-Porta R, Ball D, Crowley J et al. The IASLC lung cancer staging project: proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol 2007; 2: 593-602. Slide 15 T-Descriptors - Validation Additional Nodules and Pleural Dissemination, T3/4-M1 NSCLC United States National Cancer Institute SEER Registries From: Groome PA, Bolejack V, Crowley JJ et al. The IASLC lung cancer project: validation of the proposals for revision of the T, N, and M descriptors and consequent stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol 2007; 2: 694-705 Slide 16 N-Descriptors Clinical N-stage, cN0-cN3 From: Rusch VW, Crowley J, Giroux DJ et al. The IASLC lung cancer project: proposals for the revision of the N descriptors in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol 2007; 2: 603-612 Slide 17 N-Descriptors Surgically Managed Patients From: Rusch VW, Crowley J, Giroux DJ et al. The IASLC lung cancer project: proposals for the revision of the N descriptors in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol 2007; 2: 603-612 Slide 18 N-Descriptors - Validation N-Stage N0-N3, M0 NSCLC United States National Cancer Institute SEER Registries From: Groome PA, Bolejack V, Crowley JJ et al. The IASLC lung cancer project: validation of the proposals for revision of the T, N, and M descriptors and consequent stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol 2007; 2: 694-705 Slide 19 N-Descriptors: Nodal Zones Shown in: Rusch VW, Crowley J, Giroux DJ et al. The IASLC lung cancer project: proposals for the revision of the N descriptors in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol 2007; 2: 603-612. Copyright Memorial Sloan-Kettering Cancer Center. Used with permission. Slide 20 N-Descriptors N-Status and Number of Involved N-Zones From: Rusch VW, Crowley J, Giroux DJ et al. The IASLC lung cancer project: proposals for the revision of the N descriptors in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol 2007; 2: 603-612 Slide 21 M-Descriptors Clinically Staged T4 and M1 Descriptors From: Postmus PE, Brambilla E, Chansky K et al. The IASLC lung cancer project: proposals for revision of the M descriptors in the forthcoming (seventh) edition of the TNM classification of lung cancer. J Thorac Oncol 2007; 2: 686-693 Slide 22 M-Descriptors Best* Stage T4 and M1 Descriptors *Best Stage = Path stage if available, otherwise clinical From: Postmus PE, Brambilla E, Chansky K et al. The IASLC lung cancer project: proposals for revision of the M descriptors in the forthcoming (seventh) edition of the TNM classification of lung cancer. J Thorac Oncol 2007; 2: 686-693 Slide 23 M-Descriptors - Validation T4 and M1 Descriptors United States National Cancer Institute SEER Registries From: Postmus PE, Brambilla E, Chansky K et al. The IASLC lung cancer project: proposals for revision of the M descriptors in the forthcoming (seventh) edition of the TNM classification of lung cancer. J Thorac Oncol 2007; 2: 686-693 Slide 24 TNM Stage Category RPA Output for Analysis of TNM Stage Groupings From: Goldstraw P, Crowley J, Chansky K et al. The IASLC lung cancer project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol 2007; 2: 706-714 Slide 25 TNM Stage Category Clinical TNM Stage v. 6 and Proposed v. 7 cTNM 6 th Edition cTNM 7 th Edition From: Goldstraw P, Crowley J, Chansky K et al. The IASLC lung cancer project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol 2007; 2: 706-714 Slide 26 TNM Stage Category Pathological Stage v. 6 and Proposed v. 7 pTNM 6 th Edition pTNM 7 th Edition From: Goldstraw P, Crowley J, Chansky K et al. The IASLC lung cancer project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol 2007; 2: 706-714 Slide 27 TNM Stage Category - Validation TNM Stage v. 6 and Proposed v. 7 United States National Cancer Institute SEER Registries TNM 6 th Edition TNM 7 th Edition From: Groome PA, Bolejack V, Crowley JJ et al. The IASLC lung cancer project: validation of the proposals for revision of the T, N, and M descriptors and consequent stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol 2007; 2: 694-705