The Hyperglycemia and Adverse Pregnancy Outcome Study

Featured Article:

Patrick M. Catalano, M.D., H. David McIntyre, M.D., J. Kennedy Cruickshank, M.D., David R. McCance, M.D., Alan R. Dyer, Ph.D., Boyd E. Metzger, M.D., Lynn P. Lowe, Ph.D., Elisabeth R. Trimble, M.D., Donald R. Coustan, M.D.,

David R. Hadden, M.D., Bengt Persson, M.D. Ph.D., Moshe Hod, M.D., Jeremy J.N. Oats, M.D., For the Hapo Study Cooperative Research Group

Diabetes Care Volume 35: 780-786

April, 2012

Study Objective

• To determine associations of gestational diabetes mellitus (GDM) and obesity with adverse pregnancy outcomes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study

Catalano P et al. Diabetes Care 2012;35:780-786

Study Design

• Participants underwent a 75-g OGTT between 24 and 32 weeks • GDM diagnosed post hoc using IADPSG criteria • Neonatal anthropometrics and cord serum C-peptide were

measured • Adverse pregnancy outcomes included birth weight, newborn

percent body fat, and cord C-peptide >90th percentiles, primary cesarean delivery, preeclampsia, and shoulder dystocia/birth injury

 • Multiple logistic regression used to examine associations of

GDM and obesity with outcomes

Catalano P et al. Diabetes Care 2012;35:780-786

Catalano P et al. Diabetes Care 2012;35:780-786

Catalano P et al. Diabetes Care 2012;35:780-786

Catalano P et al. Diabetes Care 2012;35:780-786

Conclusions

 •Both maternal GDM and obesity are independently associated with adverse pregnancy outcomes •Their combination has a greater impact than either one alone

Catalano P et al. Diabetes Care 2012;35:780-786