The Human-Mouse: Disease Connection in Mouse Genome Informatics (MGI)
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Transcript of The Human-Mouse: Disease Connection in Mouse Genome Informatics (MGI)
Module 3: The Human-Mouse: Disease Connection in MGI
Clinical genetic research and translation tool
Options for beginning a search:
Gja8Mapk10Rsph9Il20raJak3Frg1
Visual display of associated phenotype and disease results
Mammalian (mouse) Phenotypes
Human disease(OMIM)
Click to drill-down for more precise MP and allele IDs
Click right side to view disease
Visual display of associated phenotype and disease results
Other tabs for Genes & Diseases lists (downloadable)
Genes tab: downloadable, find references and mouse models
Diseases tab: downloadable, find all gene associations in human and mouse
Search terms can be combined
Chr1:150000000-250000000
.
type “cleft palate” (matches whole) or
type cleft palate (matches as two terms)
or selectcleft palate Mammalian phenotype
or selectCleft Palate; CP [Cleft palate isolated, CPI] OMIM
Combined search results for region AND annotation
at least one mouse homolog genotype contains “cleft palate” (or child term) as an MP annotation
same MP genotype is a disease model, or human disease name/synonym contains “cleft palate”
Summary
The Human-Mouse: Disease connection allows rapid accession and association of gene-phenotype or gene-disease information
Allows clinical researchers with human data to perform functional or phenotypic annotation to a gene list
Straightforward discovery of mouse models
contact [email protected] with any questions