The Histological Response to Chemotherapy as a Predictor of the Oncological Outcome of Operative...

The Histological Response to Chemotherapy as a Predictor of the Oncological Outcome of Operative Treatment of

Ewing Sarcoma*

by JAY S. WUNDER, GABE PAULIAN, ANDREW G. HUVOS, GLENN HELLER, PAUL A. MEYERS, and JOHN H. HEALEY

J Bone Joint Surg AmVolume 80(7):1020-33

July 1, 1998

©1998 by The Journal of Bone and Joint Surgery, Inc.

Fig. 1 Drawing showing the locations of the seventy-four Ewing sarcomas.

JAY S. WUNDER et al. J Bone Joint Surg Am 1998;80:1020-33


Figs. 2-A through 2-D: Histological responses of Ewing sarcomas to preoperative chemotherapy.



Figs. 2-A and 2-B: No necrosis (grade I) (x 40 and x 100, respectively).



Fig. 2-C Almost complete necrosis (grade III) (x 40).



Fig. 2-D Complete necrosis (grade IV) (x 40).



Fig. 3 Graph showing the relationship between event-free survival and the histological response of the tumor to preoperative chemotherapy (p = 0.0001), with 95 per cent confidence intervals.



Fig. 4 Graph showing the relationship between event-free survival and the number of cycles of preoperative chemotherapy (p = 0.08), with 95 per cent confidence intervals.



Fig. 5 Graph showing the relationship between event-free survival and the size of the tumor (p = 0.001), with 95 per cent confidence intervals, for sixty-three patients.



Fig. 6 Graph showing the relationship between event-free survival and the location of the primary tumor (p = 0.1), with 95 per cent confidence intervals.



Fig. 7 Graph showing the relationship between event-free survival and the presence or absence of metastases at the time of the diagnosis, with 95 per cent confidence intervals.



The Histological Response to Chemotherapy as a Predictor of the Oncological Outcome of Operative...

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