The Gut Fat-Loss Connection - Fat Is Not Your...

The Gut Fat-Loss Connection | Supplementary Materials & Resources

www.fatisnotyourfault.com©2008, 2010, 2011 Dr. Bryan P. Walsh

The Gut Fat-Loss ConnectionSupplementary Materials & Resources

Disclaimer: Information contained in this book is not intended to provide treatment for any disease, disability, ormedical condition, or to substitute for personal, individual medical care from a qualified physician. The reader isadvised to check with his or her own physician prior to following any recommendations given in this book or any of itsreferences. Every attempt has been made to provide accurate information. However, the reader is on notice that theinformation in this book has been compiled and written to address general principles. It is not intended as specificadvice for any individual. Thus, the personal application of any information provided herein is the sole responsibility ofthe user and, if implemented, would be applied at his or her own risk.

SUMMARY

The gastrointestinal system is one of the most critical systems to have functioning optimally ifideal health, wellness and fat loss are desired. Gastrointestinal dysfunction is rampant todayand not surprisingly, has been associated with almost every chronic disease. Correctinggastrointestinal dysfunction of any kind is of paramount importance in optimizing health andfat loss.

While the gastrointestinal system is somewhat complex, barring any overt pathological process,the most common dysfunctions today include deficiency of hydrochloric acid and/or digestiveenzymes, inflammation, intestinal permeability, exposure to food sensitivities, dysbiosis(imbalance of good to bad bacteria) and infection. The gastrointestinal system turns over, orreplaces, itself very quickly making correcting for any of these issues is relatively simple andrapid. It takes some diligence on the part of the individual, but with strict adherence to certaindietary correction as well as supplementation, improved gut function is relatively easy toachieve.

TESTING



There are many ways of evaluating the function of the gastrointestinal system, each offeringinformation not available from other methods, and all of which are important to consider inidentifying underlying gastrointestinal issues.

Evaluation should first start with symptoms. If an individual has symptoms of gas, bloating, badbreath, heartburn, diarrhea, constipation or a combination of both, or a history of antibioticuse, gastrointestinal dysfunction is certain. Therefore symptoms are valuable at identifying anissue, but lab testing helps identify why a certain symptom may be present. Laboratory testingcan be invaluable in helping to identify and correct underlying gastrointestinal imbalances.

BLOOD CHEMISTRY

Blood chemistry is one of the most useful, valuable and cost effective lab tests you canrun. It is impossible to evaluate gastrointestinal health using blood chemistry, but youcan get some insight. There are a few markers seen in a blood chemistry that can behelpful.

The first two markers, protein and globulin, are helpful in indicating possiblehydrochloric acid (HCL) deficiency and concomitant proteinmalabsorption/maldigestion. As covered in the videos, HCL is important for starting thedigestive process, stimulating the body to produce enzymes responsible for breakingdown the food, and sterilizing our food to protect us from a gastrointestinal infection.

When protein and globulin are either above or below the optimal reference range, youmay have inadequate production of HCL. If one of these markers is outside of thefunctional reference range, there is a slight possibility that you may have inadequateproduction of HLC, but if both makers are outside of the functional reference range –either high or low – there is a greater likelihood of poor HLC production and thereforeneed for HCL supplementation for a period of 3-6 months, as well as a furtherinvestigation into gut function.

Marker Optimal Reference RangeProtein 6.9-7.4 g/LGlobulin 2.4-2.8 g/100ml

The other blood chemistry marker that can help identify a possible gastrointestinal issueis called eosinophils. Eosinophils are one type of white blood cell that, when elevated,can indicate a possible parasitic infection. Elevated eosinophils can also indicateseasonal allergies.

If eosinophils are elevated above 3%, one may consider running a stool test to furtherevaluate the possibility of a gastrointestinal parasitic infection. Ultimately a standard



blood chemistry will point you in certain directions for additional testing and elevatedeosinophils are one such marker. If they are elevated, whether or not there aregastrointestinal symptoms, consider getting a stool test (below) for more detailedinformation about the health of the gastrointestinal system.

Marker Optimal Reference RangeEosinophils 0-3%

STOOL TESTING

Stool testing can be of tremendous value when evaluating gastrointestinal function andshould be considered in anyone suffering from any gastrointestinal symptoms (i.e. gas,bloating, constipation, diarrhea, etc).

Currently the best stool test is the GI Effects Test from Metametrix Laboratories inAtlanta, GA. There are many other stool tests available but the technology used byMetametrix is among the most advanced and their testing procedures are second tonone.

Two GI Effects tests are available:

1. GI Effects Microbial Profile, which looks specifically at gastrointestional infection(i.e. bacteria, fungus/yeast, parasites)

2. GI Effects Profile, which includes the above panel as well as markers looking atdigestion, absorption and inflammation

The latter of the two is the more comprehensive, and therefore more expensive, of thetwo tests. If finances are limited the Microbial Profile will be of tremendous value, but ifa complete assessment of gastrointestinal function is desired, the GI Effects Profileshould be considered.

While interpretation of this test by a skilled clinician is invaluable, a sample of what isincluded in the GI Effects Profile is included at the end of this document.

ADDITIONAL FUNCTIONAL LABORATORY TESTING

Thus far the previous two tests evaluated 1) hydrochloric acid and protein digestion, 2)infection, 3) inflammation and 4) overall digestive and absorption function. The lastimportant component is intestinal permeability.



INTESTINAL PERMEABILITY

Intestinal permeability, also called “leaky gut”, is a situation where the junctionsnormally keeping gastrointestinal cells together have become weak or damaged and areallowing partially undigested particles into the blood stream. This is highly undesirableas the body only recognizes certain molecules of digestion including glucose, aminoacids and lipids, broken down into their most simple structure. Anything larger thanthat is seen as foreign (i.e. an antigen) and therefore is not only unwanted by the body,but attacked by the immune system. If intestinal permeability is present, optimal healthand fat loss is impossible.

The newest intestinal permeability test on the market is one by Cyrex Laboratories andis the lab of choice for determining whether “leaky gut” is present, and to what degree.It is a simple blood test and is worth its value in gold if intestinal permeability is present.

FOOD ALLERGY/SENSITIVITY

Food sensitivities are one of the most common and strongest contributors togastrointestinal dysfunction. Therefore one the best ways to improve digestive health isto remove and avoid foods one is sensitive to. The gold standard for identifying foodsensitivities remains the Elimination Diet. However after following the Elimination Diet,if symptoms persist, additional testing may be valuable. The following lab tests mayhelp identify additional food sensitivities not identified during the Elimination Diet.

LEAP MRT Food Sensitivity Testing

Many food allergy tests have questionable validity and reliability. While the LeapMRT test is not immune to these issues, it has proved to be a valuable part of ourpractice over the years in patients that continue to experience unwantedsymptoms after strictly following the Elimination Diet. The LEAP MRT testdiffers from most food sensitivity tests in that, it doesn’t look specifically at end-stage food sensitivity markers (i.e. immunoglobulins) but rather looks at how theimmune system actually reacts to exposure to certain foods. Again, this isn’t aninitial test we would consider running in a patient but, when people have beendiligently following an Elimination Diet and continue to experience unwantedsymptoms, the LEAP MRT Food Sensitivity test can offer valuable information.

Gluten-associated cross-reactive foods and foods sensitivity

Another test offered by Cyrex Laboratories allows patients to evaluate possiblesensitivities to foods commonly eaten while following a gluten-free diet. Quinoa,



millet and certain dairy products are technically gluten-free and are thereforetypically eaten by people following a gluten-free diet. However, it is possiblethat these foods cause a gluten-like reaction unbeknownst to the individual.Therefore, testing for possible gluten cross-reactive foods can be very helpful ifcertain symptoms persist even while following a gluten-free diet.

EVALUATION

There are really two philosophies when it comes of evaluating gastrointestinal disturbances.One, if specific imbalances are found on testing, the goal is to correct the specific imbalances.For example, if someone has a specific infection (i.e. candida), simply nutritionally eradicate theinfection and all will be well. This is typically a conventional medicine philosophy.

The second way however is, if a gastrointestinal imbalance is found, assume some degree ofdysfunction in the entire digestive system, and therefore corrects everything whether or notspecific imbalances are found. For example, if an infection is identified, the assumption is madethat there is also some degree of hydrochloric acid deficiency, enzyme deficiency, inflammationand intestinal permeability present. While making assumptions regarding the body is generallya bad idea, this is one instance where making attempts at correcting every element of thegastrointestinal system will prove beneficial. More information on this is found in theCorrecting Imbalances section below.

CORRECTING IMBALANCES

One of the most successful approaches at correcting any and all gastrointestinal imbalances iscalled the Four “R” Procotol. The four R’s are:

1. Remove2. Replace3. Repair4. Reinnoculate

REMOVE

The remove phase of the program involves removing anything that may be causinggastrointestinal dysfunction. The two main culprits are 1) infection (i.e. bacteria,fungus/yeast, parasite) and/or 2) food sensitivities.

Therefore the remove phase typically involves following an Elimination Diet as well as aanti-microbial protocol to eliminate any possible infections. An example of an



Elimination Diet, as well as an anti-microbial protocol, is found in the Appendix sectionof this document.

Typically the Removal phase will take anywhere from 3-6 weeks depending on thedegree and severity of food sensitivities and infection. The avoidance of any foodscausing inflammation, as well as the eradication of any unwanted infection, isparamount in correcting gastrointestinal dysfunction.

REPLACE

The focus of the Replace phase is to give the body what it needs for optimalgastrointestinal function that otherwise might be missing due to dysfunction.Specifically, this phase often includes the use of hydrochloric acid and digestiveenzymes, as these are typically deficient in the dysfunctional gastrointestinal tract.

REPAIR

The Repair phase focuses on delivering specific nutrients found to support the healthyfunction of gastrointestinal cells. While this phase is important, it should only beemployed after successful completion of the previous two phases as it is impossible tohave optimal gastrointestinal function in the presence of food sensitivities and/or gutinfection. Nutrients that support this phase of the Four R Program can be found in theNutritional Support section below.

REINNOCULATE

Last but not least is supplying the gastrointestinal tract with healthy bacteria.Unfortunately this phase is one of the first therapies people try and, while it is criticallyimportant, correcting the other three phases is important as dysfunction in any of themwill make the Reinnoculation phase difficult to maintain. For example, if someone lacksadequate hydrochloric acid in their stomach, they are more likely to allow an unwantedpathogen in to the digestive tract, which can cause an unfavorable bacterial balance andpotentially a lifelong dependence on probiotics until the underlying pathogen iseradicated.

AN EXAMPLE OF A FOUR “R” PROGRAM

Given our biochemical individuality as well as a number of other factors, there is no oneperfect protocol. However, here is a sample program we have found helpful in ourclinical practice:



Days 1 through 30 - REMOVE - Elimination Diet & Anti-Microbial Protocol

The Elimination Diet is followed for three weeks, followed by a one week reintroductionphase. During that time, the following supplements are used (only when under thesupervision of a licensed medical professional):

GI MicrobX (Designs for Health) – two capsules, three times a day with meals Oil of Oregano (Designs for Health) – one gel cap morning and evening, with meals FloraMyces (Designs for Health) – one capsules morning and evening, away from

meals Allicillin (Designs for Health) – one capsule morning and evening, with meals Olive Leaf Extract (Designs for Health) – one capsules three times a day with meals Interfase (Klarie Labs) – one capsule morning and evening away from meals

Days 31 through 60 – REPLACE, REPAIR, REINNOCULATE

For thirty days, take the following products (as monitored by a qualified health careprofessional):

Betaine HCL (Designs for Health) – one to two tablets (or more as necessary) rightbefore a meal

DigestZyme (Designs for Health) – one to three capsules with every meal GI Revive (Designs for Health) – one to three scoops a day Pro-Bio 12 (Klaire Labs) – one capsule twice a day, away from meals

Days 61 – 90 – REINNOCULATE*

Original Symbiotic Formula (Bioimmersion) – One capsule twice a day, away frommeals

*Digestive enzymes, hydrochloric acid and repair formulas can be taken as necessary

Days 91 – 120 – REINNOCULATE*

Supernatant (Bioimmersion) – One capsule twice a day, away from meals*Digestive enzymes, hydrochloric acid and repair formulas can be taken as necessary

NUTRITIONAL SUPPORT

Most herbs and supplements have not been thoroughly tested for interactions with otherherbs, supplements, drugs, or foods. The interactions listed below are based on reports inscientific publications, laboratory experiments, or traditional use. You should always readproduct labels. If you have a medical condition, or are taking other drugs, herbs, or



supplements, you should speak with a qualified healthcare provider before starting a newtherapy.

COMPOUNDS TO CONSIDER IN GUT INFECTION

Below is a list of well-known adaptogens that may be helpful in nutritionally correctingunderlying gut dysfunction:

Berberine

500mg three times a day

Berberine is a bitter-tasting, yellow, plant alkaloid with a long history of usage inAyurvedic and Chinese medicine dating back approximately 3,000 years. The constituentberberine has antimicrobial activity against bacteria, fungi, protozoans, viruses,helminths, and Chlamydia. Berberine possesses antimicrobial effects includingantibacterial, antifungal, antimycobacterial and antiprotozoal activity. Berberine alsohelps control inflammation in the GI tract by selectively inhibiting cyclooxygenase (COX)-2 expression and blocking the proinflammatory cytokines interleukin-1 (IL1)-beta andtumor necrosis factor (TNF)-alpha as well as nuclear factor-kappaB, the transcriptionfactor responsible for regulation of cytokine production.

Undecylenic Acid

450-750mg daily in divided doses

Undecylenic acid is an eleven-carbon monounsaturated fatty acid found naturallyoccurring in the body and commercially is derived from castor oil. It has demonstratedpotent anti-fungal properties. At least one of the mechanisms underlying its anti-fungaleffect is the inhibition of morphogenesis of Candida albicans by interfering with fattyacid biosynthesis, disrupt the pH of the cell cytoplasm and inhibiting hyphae formation.

Caprylic Acid

300-1,200mg daily, preferably 30 minutes before meals

Caprylic acid is the common name for the eight-carbon straight chain fatty acid knownby the systematic name octanoic acid. It is found naturally in palm and coconut oil, andin breast milk. Doctors and nutritionists often recommend caprylic acid for use intreating candidiasis and bacterial infections. Due to its relatively short chain length it has



no difficulty in penetrating fatty cell wall membranes, hence its effectiveness incombating certain lipid-coated bacteria, such as Staphylococcus aureus, various speciesof Streptococcus, and intramucosal Candida. Caprylic acid may affect the fluidity of viraland fungal cell membranes. Studies have reported that dietary caprylic acid inhibits thegrowth of Candida albicans and other opportunistic fungi in both the small and the largeintestine. At the same time, caprylic aciddoes not seem to adversely affect the growthof beneficial intestinal microflora.

Uva Ursi (Arctostaphylos uva-ursi)

200-500mg daily in divided doses

Arctostaphylos uva ursi is grown throughout Asia, North America, and Europe and has along history of medicinal use dating back to the 13th Century. The leaves have beenused worldwide as a diuretic, astringent, antiseptic and treatment for urinary tract andgastrointestinal infections. A tea brewed with the leaves has also been used as alaxative. Arbutin, the main chemical constituent of uva ursi, is a phenolic glycoside thatbecomes hydrolyzed to hydroquinone. Both chemicals contribute to the antisepticeffects in the urinary and GI tracts. Other active constituents include tannins, mono andtriterpenes, and flavonoids. Arbutin alone has also been reported to relieve pain fromkidney stones, cystitis and nephritis.

Grapefruit Seed Extract

400mg daily in divided doses

Grapefruit and other citrus seed extracts have long been used as antiseptics. They havebeen most specifically applied clinically to reduce fungal overgrowth by such commonorganisms as candida and geotrichum. Citrus seed extract also has demonstratedantibacterial function, most notoriously with hemolytic coliform bacteria.

Tribulus terrestris

85-250mg (40% furostanol saponins extract) in three divided doses

Tribulus terrestris, most well known for its purported testosterone raising effects, has along history of use for a variety of conditions. It has been suggested that it was used inancient Greece and India as a physical rejuvenation tonic. Its health and medicinal uses,including its anti-parasitic and anti-fungal effects, are the result of active



phytochemicals including steroidal saponins currently referred to by medicalresearchers and physicians as X steroidal saponins. These X steroidal saponins have theability to influence the entire immune system of the body and have been shown to haveanti-bacterial and anti-viral effects.

Juglans nigra (Black Walnut)

1,000mg three times a day (not to exceed six weeks)

Black Walnut has a long history of use as an intestinal anti-parasitic in botanicalmedicine. It also posseses activity against common bacterial and fungal pathogens thatoccur in GI dysbiosis. Based on anecdote, black walnut has been used to relieveconstipation and diarrhea, due to a normalizing effect that juglone may exert onintestinal tissue. Black walnut also contains tannins which have astringent propertiesand, therefore, reduce secretions and may relieve irritation and improve tissue firmness.

Artemesia anuua (Sweet annie, Wormwood)

1,000mg three times a day (not to exceed six weeks)

Sweet annie (Artemisia annua) is also known as Chinese wormwood or sweetwormwood. Although it is in the same genus as both wormwood (absinthe, Artemisiaabsinthium) and mugwort (Artemisia vulgaris), each of these herbs have different usesand should not be confused. Sweet annie demonstrates significant antimicrobial effectsincluding having antiparasitic, antifungal, and antibacterial properties. It has a particularhistoric use of being used to treat parasitic gastrointestinal infections therefore itbecame known by the common name of wormwood.

Cat’s Claw

250-1,000mg three times daily

Cat's claw has a long history of traditional use among the indigenous peoples of SouthAmerica and dates back to the Incan civilization. It has been used to treat cancer,arthritis, inflammation, digestive problems, ulcers, and to promote wound healing.Cat’s Claw has been found to have potent antioxidant, anti-inflammatory, anti-bacterial,anti-fungal, and immunomodulation properties. In laboratory study, micropulverizedUncaria tomentosa showed antimicrobial activity on Enterobacteriaceae, Streptococcusmutans, and Staphylococcus spp.



Pau D’Arco (Tabeuia spp.)

1,000mg three times daily

Tabebuia, commonly called taheebo or pau d'arco, is a genus of tropical plants native tothe rain forests of Central and South America. Pau d'arco has traditionally been used asa folk medicine to treat bacterial infection, cancer, inflammatory diseases, and pepticulcers. In vitro and animal research suggests antiplatelet, anti-inflammatory,immunomodulatory, and wound-healing effects. In addition to its anti-bacterial andanti-fungal properties, Pau D’Arco has also been shown to decrease intestinal damageand increase mucous production.

Olive Leaf Extract (Olea europaea)

500mg three times a day

Olive leaves come from the olive tree (Olea europae), a native of the Mediterranean.Although olives and olive oil are used as foods, olive leaf is primarily used medicinally oras a tea. In vitro studies indicate potent antibacterial, antifungal, and antioxidantproperties.

Garlic (Allium sativum)

The World Health Organization (WHO) 1999 monograph recommends 2-5g of freshgarlic, 0.4-1.2g of dried powder, 2-5mg of oil, 300-1000mg of extract, or otherformulations corresponding to 2-5mg of allicin.

Garlic is a member of the lily family and has a long history of medicinal uses. In fact,Egyptian medical papyrus from 1550 BC, mentions garlic as a remedy for a number ofailments, including hypertension, worms, and tumors. The sulfur compound alliinproduces allicin via the enzyme allinase when the bulb is crushed or ground. Though theexact mechanism of action underlying garlic's effects remains unknown and may varyaccording to the preparation and the therapeutic effect, garlic has shown to havepowerful anti-bacterial, anti-fungal, anti-parasitic, anti-inflammatory, anti-viral, andantioxidant effects.



COMPOUNDS TO CONSIDER IN GUT INFLAMMATIONThe following compounds may be helpful in healing the mucosal cells of the intestinal tract:

L-glutamine

1-8 grams a day in divided doses

L-glutamine is an amino acid that has not only been shown to be protective of thegastrointestinal system but, as the preferred fuel source of gut cells, also helps repairand rebuild damaged mucosal tissue. L-glutamine has been shown to not only repair guttissue, but also improve the formation, number and height of villi. It is a precursor forthe intracellular antioxidant glutathione, and may also offer immune system support aswell as antioxidant activity. L-glutamine is medically used during trauma, infections andburns.

N-acetyl-glucosamine (NAG)

Dose will vary depending on supplement manufacturer

N-acetyl glucosamine is the acetylated derivative of the amino sugar glucosamine. N-acetyl-glucosamine has been shown to help support proper mucosal health as well asreduce intestinal permeability. It has been found to be deficient in inflammatory boweldisease, reducing the synthesis of the gastric and intestinal mucoa’s protectiveglycoprotein cover. Dietary supplementation with NAG can support intestinal mucinproduction .

Methyl Sulfonyl Methane (MSM)

1-3 grams daily in divided doses

MSM has proven anti-inflammatory and antioxidant properties in numerous studies.MSM is rich (34%) in natural sulfur, which can help support certain detoxificationpathways in the liver. It has also been used for musculoskeletal and joint pain, allergiesand for immunomodulation.



Deglycyrrhizinated licorice (DGL)

380-1,140mg three times daily (taken at least 20 minutes prior to meals)

Deglycyrrhizinated licorice (DGL) has a long history of being associated withimprovement of upper GI health, including healing ulcers. However, DGL has also beenshown to decrease intestinal irritation and associated symptoms. It has been shown toimprove intestinal blood flow, increase formation and secretion of intestinal mucous,and help regenerate cells lining the intestinal tract.

Marshmallow (Althaea officinalis)

Leaf: 5g of leaf or equivalent preparation daily; Root: 6g of root or equivalentpreparation daily.

Marshmallow leaf and root has a high content of mucilage that can soothe and help healcompromised intestinal barrier tissue. These mucilaginous polysaccharides help sootheand protect mucous membranes from local irritation by creating a protective layer. Themucilage properties can also have antimicrobial, antispasmotic, and wound-healingeffects. Marshmallow also has properties that inhibit the enzyme hyaluronidase, whichinvolved in the production of hyaluronic acid involved with intestinal tissue destruction.

Cabbage

Raw cabbage juice may be taken as one tablespoon three times daily before meals

Historically called vitamin U, cabbage does not meet the official criteria to achievevitamin status. However cabbage constituents offer significant protection to the GI tractand thus the body in general. Individuals who consume large amounts of cabbage andother Brassica vegetables have a lower risk of developing stomach and colorectalcancer. For example, one study showed that raw cabbage juice consumed by 100 pepticulcer patients dramatically reduced pain, and significantly reduced healing time.Cabbage also possesses potent antioxidant effects.

Slippery Elm

400-500mg three times daily in divided doses

Slippery elm provides numerous nutrients and compounds that provide mucilage to thegastrointestinal tract. Slippery elm has been shown to increases mucous secretion from



the intestinal tract, providing protection and support for inflamed intestinal cells.Slippery elm is traditionally used to treat inflammatory conditions of the digestive tractsuch as gastritis, peptic ulcer disease, or enteritis. It may be taken alone or incombination with other herbs. While anecdotally reported to be effective, supportingevidence is largely based upon traditional evidence and the fact that the mucilagescontained in the herb appear to possess soothing properties.

Phosphatidylcholine


Phosphatidylcholines are a class of phospholipids found in cell membranes and may beisolated from either egg yolk or soy beans. Phosphatidylcholine is also a majorcomponent of lecithin. Although phosphatidylcholine phospholipids are present inalmost all cells within the body, the highest concentrations may be found in the brain,heart, liver, and kidneys .Phosphatidylcholine (PC) has been shown to be deficient inpatients with ulcerative colitis, and was thought to contribute to the development ofthat condition. PC has been shown to support intestinal function and cellular synthesis.

Gamma Oryzanol


Gamma oryzanol is extracted from rice bran oil and has a number of beneficial effectson the body, including antioxidant properties, gastrointestinal modulation and possiblecholesterol-lowering effects. Each year Japan manufactures 7,500 tons of gammaoryzanol from 150,000 tons of rice bran. Not surprisingly, most of the research onoryzanol has been performed in Japan. It has been used for a number of specific andnon-specific gastrointestinal issues.

Quercitin


Quercitin can also provide direct anti-inflammatory action by stabilizing intestinal mastcells and can improve tissue health through its antioxidant functions. It has been shownto be protective of gastric ulceration, possibly by inhibiting H.Pylori growth and lipidperoxidation of gastric (stomach) cells. Quercitin is implicated in an inflammatory



condition as it has been shown to help decrease certain inflammatory mediators (i.e.prostaglandins, leukotrienes, histamine).

Mucin

A glycoprotein, normally secreted by the intestinal epithelial cells, containing sialic acidand N-neurominic acid. Mucin can serve to coat the intestinal lining and to neutralizeintestinal antigens, along with sIgA, reducing the inflammation and tissue damagecaused by food allergy, intestinal infection and dysbiosis.

Aloe Leaf Extract

150mg of the dried aloe juice daily (may have a laxative effect)

Aloe leaf extract has been used for thousands of years to help intestinal wound healing.It may improve gastrointestinal transit time, increase protein digestion and absorption,increase stool bulk and may have anti-fungal properties. There is much anecdotalevidence that Aloe can help soothe the intestines and aid in healing of intestinalmucosa.

Matricaria chamomilla (German Chamomile)

As a tea, 2-3g of chamomile, steeped in 150mL hot water, has been taken 3-4 times dailybetween meals; 400-1,600mg daily in divided doses (standardized to 1.2% apigenin and0.5% essential oil per dose)

German chamomile has been shown to have a number of different effects includingantibacterial, antifungal, anti-inflammatory, antispasmodic, anti-ulcer, antiviral, andsedative properties. Studies have demonstrated its ability to improve wound healing,decrease mucosal inflammation and decrease the duration of diarrhea.

Calendula officinalis (Calendula; Marigold Flower)

Traditionally, calendula has been used topically to treat minor wounds, burns, and otherskin problems. The principal identified constituents of calendula are triterpenoids andflavonoids. It has been used historically for varied gastrointestinal complaints and hasshown antibacterial, anti-inflammatory, antioxidant and anti-spasmotic effects. It hasbeen proposed that Calendula officinalis extract may aid in wound healing by promoting



epithelial growth and by enhancing immune responses, including in the gastrointestinalsystem. It also provides substrates for digestive enzyme production, helps duringinflammation, and provides antibacterial activity.

Saccharomyces boulardii

500mg twice a day

Saccharomyces boulardii is a non-pathogenic yeast strain that has been used fortreatment and prevention of diarrhea resulting from multiple etiologies. Saccharomycesboulardii is classified as a "probiotic," or a microorganism that when ingested may havea positive influence on the host's health. It will not be affected by antibiotics and hasbeen used for a host of intestinal conditions, including traveler’s diarrhea, irritablebowel syndrome, dysbiosis, deficient secratory IgA, and inflammatory bowel conditions.

The basic functions of immunoglobulins are the neutralization and opsonization ofbacteria, viruses and other environmental pathogens. Unlike antibiotics, they allow theimmune system to differentiate pathogens from the body’s normal microflora.

Larch Arabinogalactan

1-5g a day in divided doses

Arabinogalactans are polysaccharides with a galactan core and side chains of galactoseand arabinose sugars. For dietary consumption, arabinogalactan is isolated from thewood of the larch tree (Larix species) and is approved for use as a dietary fiber. As adietary supplement, larch arabinogalactan is used for its potential immunostimulating,anti-cancer, and prebiotic properties. In healthy humans, arabinogalactan increasedlevels of total fecal anaerobes as well as Lactobacillus spp. There were no changes inother microflora, fecal enzyme activity, transit time, frequency, fecal weight, fecal pH, orshort-chain fatty acids. Fecal ammonia levels also decreased. Bacteria able to grow onarabinogalactan have been isolated from human feces.

Immunoglobulins

2,500mg of mixed immunoglobulins twice a day



Each day the G.I. tract immune cells produce about 5 grams of immunoglobulins.However, during times of stress there is significantly reduced secretion. Supplementalimmunoglobulins act first in the intestinal tract to eliminate or inhibit the proliferationof disease-causing organisms and toxins. This reduces the stimulation of the immuneresponse in the gut so that the body’s resources can be redirected toward challengeselsewhere. Studies have shown oral immuno-protein supplementation restoresappetite, reduces inflammation, and promotes improved protein metabolism underimmunological stress. Oral supplementation has been shown to preserve gut wallintegrity and provide intestinal humoral immunity. Extrapolated data from a humanclinical trial on IBS demonstrated sufferers could experience 35 extra IBS symptom-freedays annually.

Inulin


Inulin is a prebiotic fermented by intestinal flora to produce short chain fatty acids,including butyrate. Butyrate, a major short-chain fatty acid produced in the human gutby bacterial fermentation of dietary fiber, is an important energy source for cells liningthe intestine and therefore plays an important role in the maintenance of colonicbalance. Butyrate has been shown to inhibit inflammation, reinforce the colonicdefense barrier, decrease oxidative stress and promote satiety.

SPECIFIC FORMULAS

Some products and formulas will work better for some people than they will for others.Therefore the best method in nutritionally supporting blood sugar and insulin dysregulation isto try certain products for 30 days and retest laboratory markers to determine if a positivebenefit was achieved. If so, continuing on a certain protocol will likely be beneficial in correctingblood sugar imbalances.

On the other hand, if negative symptoms exist using a specific formula or compound or, iflaboratory markers do not improve, either adjusting the dose or trying a different protocol isnecessary. If after 90 days laboratory markers and/or symptoms do not improve, it is likely thatthe particular mechanism driving the physiological imbalance has not been adequatelyaddressed.

No protocols are listed here simply because there generalized protocols to fix physiologicalimbalances simply do not exist. Finding an effective protocol requires evaluating your



particular physiological imbalances and then experimenting with different products, followedby retesting, to determine the most effective products and dosages for you.

Here are some specific professional formulas that may be beneficial in helping to correct gutdysfunction:

Xymogen: IgG 2000 DF, GI Protect, MedCaps GI, GastrAcid, GlutAloeMine, IgG Pure, ProbioDefense, ProbioMax, Saccharomycin DF

Apex Energetics: RepairVite, Yeastonil, Parastonil, Strengtia

Vital Nutrients: Berberine

Designs for Health: Olive Leaf Extract, Oregano Oil, Allicillin, GI-MicrobX, FloraMyces, GI-Revive,Betaine HCL, Digestzymes

Klaire Labs: Probiotics

RESOURCES

www.celiac.orgFor those interested in following a gluten-free lifestyle, the best way to find recipes, gluten-freealternatives and how to transition into this way of eating is to read other’s experiences. This websiteoffers some of the best information from a real-world perspective and can save you hours of researchon your own.

www.metametrix.comOne of the better functional laboratories in the United States, Metametrix offers a number offantastic tests, including the GI Effects Test.

www.directlabs.com/fatisnotyourfaultA variety of blood, salivary and stool testing is available from this website for peopleliving in the United States (except NJ, NY and RI).

www.cyrexlabs.comAn up-and-coming lab with amazing immunology panels, including the Intestinal Permeabilitytest and Gluten Cross-Reactivity test, Cyrex offers the next generation of immune systemfunctional lab testing.

http://www.nowleap.com/Food sensitivity testing using the MRT Food Sensitivity Test.



APPENDIX

HOW TO DO AN ELIMINATION DIET

The best elimination diets remove the most foods. Generally speaking, the more restrictive thebetter. A good elimination diet will remove gluten, dairy, soy, eggs, corn, pork, beef, chicken,beans/lentils, coffee, citrus fruits, nuts, and nightshade vegetables. That might sound like a lot,but it leaves plenty of options for a relatively satisfying diet comprised primarily of rice, meat(i.e. turkey, fish, lamb), most fruit and green leafy vegetables. The following table gives anexample of what to include and exclude during an elimination diet.

To personalize the diet even further, you may consider removing any foods you eat frequently.For example, it is not uncommon for people in the fitness industry to eat a particular food, suchas chicken, almost every day. For these people, it is recommended to replace the mostfrequently eaten foods with an alternative (i.e. turkey, duck, quail, etc.).

The length of an elimination diet can vary depending on severity of symptoms. Children canusually see benefit from a 7-10 day elimination diet, while most adults seem to do wellfollowing the program for around three weeks. Macronutrient ratios are not important duringan elimination diet, only the complete avoidance of certain foods. During the elimination dietyou must be sure you are consuming adequate amounts of water and having regular bowelmovements daily.

Reintroduction

After three weeks, it’s time to reintroduce foods. While maintaining the elimination diet,reintroduce one food for one day and monitor your symptoms for the next two days. Forexample, you might decide to reintroduce dairy on Sunday. That day you could eat somecheese, ice cream, and drink a couple glasses of milk, and while maintaining the eliminationdiet, monitor for any abnormal reactions on Monday and Tuesday. If you have no observablesymptoms, you may try reintroducing another food (i.e. eggs) on Wednesday. Continue thisprocess for a couple more weeks, reintroducing one new food every few days, until you havedetermined what foods may cause you an issue. The whole process will take approximately 5-6weeks.

What To Look For

The first thing to pay attention to is how you’re feeling during the elimination diet itself. Forexample, you’ll want to monitor your sleep, mood, energy, digestion, bowel habits, etc.



Keeping a journal during the diet can be helpful. If you feel better during the diet (i.e. moreenergy, better sleep), it may indicate that a food you commonly eat is causing you a problem.

The second thing to watch for is symptoms during the reintroduction. Negative reactions caninclude insomnia, joint pain, skin breakouts, headaches, bowel changes, bloating, brain fog, orsinus issues. Virtually anything that is different than you felt during the previous three weekscould be a symptom, negative or positive. For example, some people actually report increasedenergy when a given food is reintroduced. This can have been created by a stress responsefrom a certain food, which would be a negative reaction.

An Additional Tool - The Pulse Test

One additional tool you can use during the reintroduction is the pulse test.

First thing in the morning, after resting for about 5 minutes, take your pulse for one minute.Then consume the food you’ve decided to reintroduce (i.e. dairy), and retake your pulse at 20,40, 60, 90 and 120 minutes after the challenge. A change in pulse, either increased ordecreased, greater than 10 beats per minute, can indicate sensitivity to a given food. Ifrepeated again later in the day when the second exposure to the food occurred further one’ssuspicion of a food intolerance.

Obviously pulse rate can vary for a number of reasons and therefore this test is not diagnosticof food intolerance, but when correlating it with symptoms, can add additional valuableinformation.

Keys For Success

The more you put into the elimination diet, the more you get out of it. The number one key tosuccess with this diet is preparation. People that spend the week prior to starting the programlooking up recipes that are elimination diet friendly do far better than people that jump rightinto it.

Food preparation breeds success as well. For example, making a large pot of rice, completewith vegetables, protein and seasonings ahead of time can help increase compliance duringthose times when you get hungry and have few options nearby.

Lastly, keeping a journal of symptoms, energy and mood throughout the day can help identifyany patterns with food intake and physical/mental symptoms.

Summary

There is no reason to not try an elimination diet. Food has a more powerful reaction on ourbody and immune system than many people realize, and in many ways the health of our



digestive tract strongly impacts the health in the rest of our body. Food has the power topromote health or create disease, and following an elimination diet can be a rewarding andeye-opening experience. Give it a try. What you give up temporarily in creature comforts youwill gain in lasting and unequivocal knowledge about your own health and well-being.

FOODS TO INCLUDE FOODS TO EXCLUDE

Fruits Any fresh fruit Citrus fruits (orange, grapefruit,lemon, lime, etc)

Vegetables All fresh raw, steamed, sautéed, or roastedvegetables

Tomatoes, eggplant, potatoes(sweet potato and yams are okay)

Starch Rice, buckwheat Wheat, corn, barley, spelt, kamut,rye, oats, all gluten-containingproducts

Legumes Soybeans, tofu, tempeh, soy milk, allbeans, peas, lentils

Nuts and seeds All seeds and nuts

Meat and Fish Fish, chicken, turkey, lamb, wild game Beef, pork, cold cuts, bacon,hotdogs, canned meat, sausage,shellfish, meat substitutes madefrom soy

Dairy products andmilk substitutes

Unsweetened rice milk, almond milk,coconut milk

Milk, cheese, cottage cheese,cream, yogurt, butter, ice cream,non-dairy creamers, eggs

Fats Cold-expeller pressed olive oil, flaxseed oil,coconut oil

Margarine, butter, processed andhydrogenated oils, mayonnaise,spreads

Beverages Drink plenty of fresh water, herbal teas (i.e.Rooibos)

Alcohol, caffeine (coffee, black tea,green tea, soda)



Spices andcondiments

Sea salt, fresh pepper, fresh herbs and spices(i.e. garlic, cumin, dill, ginger, oregano,parsley, rosemary, thyme, turmeric)

Chocolate, ketchup, mustard, relish,chutney, soy sauce, barbecue sauce,vinegar

Sweeteners Stevia (if needed) White or brown sugar, honey, maplesyrup, corn syrup, high fructose cornsyrup, desserts

Metametrix GI Effects Test - Sample*This is a fairly restrictive elimination diet. There are lists available on the internet allowing more, andsometimes less, foods during the diet. There is technically no right or wrong way to do an eliminationdiet. The more you remove, the more likely you’ll find something you’re sensitive to.



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