The Genetics of Sickle Cell Anaemia By Katie Ridewood.
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Transcript of The Genetics of Sickle Cell Anaemia By Katie Ridewood.
The Genetics of Sickle Cell Anaemia
By Katie Ridewood
What is Sickle Cell Anaemia? A disorder that effects haemoglobin Red blood cells are “sickle shaped”
Normal RBC – biconcave
Sickle cell
What’s the effect of this sickle shape?
How does it affect people? Anaemia Severe pain Damage to organs such as: Liver, Kidney,
Lungs, Heart & Spleen
How do you get Sickle Cell Anaemia?
Genetic disorder Incomplete recessive gene for the coding of
sickle haemoglobin. 2 recessive genes required to be sickle
cell. Sickle Cell trait
Inheriting Sickle Cell
Outcomes RR Both alleles coded
correctly No sickle cell anaemia
‘rr’ Both alleles coded for
incorrect haemoglobin Will suffer from sickle
cell anaemia Likely to die before 20.
Sickle Cell Trait Rr One allele for correct haemoglobin One allele for sickle cell haemoglobin Co-dominant
Sickle cell trait X “normal” Male: RR Female Rr
Eradication of Sickle Cell… 1 in 500 African Americans 1 in 100 Africans In Africa
0.000%
0.200%
0.400%0.600%
0.800%
1.000%
% of population
Africa America
Area
% Population developing Sickle Cell Anaemia
Series1
Sickle Cell Vs Malaria Parasites use red
blood cells as hosts Sickle cells die Parasites trapped Infection reduced
Gene Pool Homozygous “normal” haemoglobin Suffer from Malaria Homozygous sickle cells Suffer from Sickle Cell anaemia Heterozygous people Don’t suffer enough from either illness
Sickle Cell & Malaria
Bibliography & References www.sicklecellsociety.org http://www.lbl.gov/MicroWorlds/xfiles/malariawhati
s.html http://chroma.gs.washington.edu/outreach/genetic
s/sickle/sickle-back.html http://www.wellesley.edu/Chemistry/Adele/Chem2
22/Syllabus/Links/bindprotns/malaria.html http://www.lbl.gov/MicroWorlds/xfiles/
malariawhatis.html