The genetics of pain by Edmund Aja Bisong, Vinnitsa 2015
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Transcript of The genetics of pain by Edmund Aja Bisong, Vinnitsa 2015
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The Genetics Of PainA chat with Pain…
Deepening and revisualizing pain, and deeper revelations of its mechanisms…
The pain hypothesis…
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Prostaglandins
• Synthesised from unsaturated
fatty acids.
• Availability of fatty acids in cell
membrane might be genome-
defined.
• Genetic favourability to having
more unsaturated fatty acids.
• The role of lifestyle in the
synthesis and availability of
unsaturated fatty acids.
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COX
• Its a protein. Proteins are
synthesised from genes.
• The amount of cycloxygenase
is gene regulated, and the
amino acids involved are also
gene regulated.
• This will affect the intensity of
pain, since cox is responsible
for the synthesis of those
nociceptive stimulants, like
prostaglandins.
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Allergies
• There’s a 50% chance of
inheritance of allergies from
parents to offspring.
• Allergies cause severe pain.
So, here is our genome again
on the fore-front of pain
causatives.
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Pain and Race
• Melanocytes filter uv light, like
sun rays; thus, preventing skin
cancer on a broad sense, and
sun-burns on a narrow sense,
that could all lead to pain.
• The healing process would be
longer in a black than a white;
since these skin cells need to
synthesise melanin, as visualised
in hyper pigmentation of skin, and
scarring mechanisms.
• We all have the same number of
melanocytes, but not melanin.
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Pseudopain?
• Masochists; an interaction
between the lateral
spinothalamic tract and the
limbic system. Overriding some
impulses…
• Mechanical stimuli can inhibit
pain fibres.
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Pain and Your Cortex
• Role of frontal cortex in pain
perception.
• Pain adaptation? We have
been told that the fibres
themselves have zero
adaptation, but, do their
interactions with the limbic
system suffer the same fate?
• Throwing light on
ACUPUNCTURE.
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Analgia Congenitalis• Mutation in the gene responsible for the
synthesis of Na+ pumps, thus, inability to
transmit pain sensation (nociception).
• Mutation of this gene in olfactory neurones
leads to anosmia.
• Analgia congenitalis can b inherited as an
autosomal recessive congenital disorder.
• If there’s a mutation in the gene responsible
for the synthesis and availability of the
enzyme cox, there’ll be absence of
healing…and maybe, absence of ageing.
The LEGEND OF VAMPIRES.
• The series; HEROES, where a high-school
girl Claire had a similar condition. Maybe
the film-makers where right.
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Pro-pain
• Organ failure.
• The viscera could feel some
sort of “pain” that we are not
even aware of.
• Think of asymptomatic stage(s)
of a disease; when your body
fights pain sub-cortically.
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THE BRAIN IS THE WHOLE UNIVERSE COMPRESSED INTO A FLUID-FILLED CAVITY…