by Sharon Moalem

A recent study provides insight into how vertebrate embryos begin to piece together their spines. Researchers had previously found that vertebrate embryos put together their vertebrae in a time-controlled sequence, a sort of genetic “clock.” But the new study, conducted by researchers from Ohio State University and McGill University, provides more detailed information on how this timed system works.

The study, published in Developmental Cell, looked at genetically modified zebrafish; they were an ideal choice since their bodies are nearly transparent. The study confirmed what researchers suspected: that embryonic cells use a communication system called the Notch pathway to coordinate their “clocks” and sequentially create vertebrae. Researchers hope that this understanding of the Notch pathway leads to better understanding of some developmental disorders, as the creation of the vertebral column is an instrumental part of vertebrate development.

Dr. Sharon Moalem is a physician, evolutionary biologist, speaker, and author who has appeared on CNN, The Today Show, and The Daily Show, as well as several other television and radio programs.