The Gazette

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11 10 10 OUR 40TH YEAR Covering Homewood, East Baltimore, Peabody, SAIS, APL and other campuses throughout the Baltimore-Washington area and abroad, since 1971. November 8, 2010 The newspaper of The Johns Hopkins University Volume 40 No. 10 Job Opportunities Notices Classifieds DELICIOUS! When do carrots taste better than candy? Psychologists’ find- ing may surprise you, page 3 RECOGNITION Young social entrepreneur is honored for pioneering a new form of activism, page 7 IN BRIEF New School of Ed blog; CTY deadline; Sibley joins JHM; Chili Cook-Off and Bake-Off time CALENDAR Provost’s Lecture Series: SoN’s Jacqueline Campbell; Donny Deutsch; Apolo Ohno 2 12 Malaysia-bound Johns Hopkins to help develop medical school and teaching hospital B Y N ATALIA A BEL Johns Hopkins Medicine International Continued on page 10 COLLABORATION Big boost for KSAS grad stipends B Y G REG R IENZI The Gazette T he School of Arts and Sciences will receive more than $5 mil- lion from the President’s Office over the next five years to fund graduate stipends. President Ronald J. Daniels made the announcement at the Oct. 23 rededication cer- emony of the newly renovated Gilman Hall, the school’s flagship building. The investment, Daniels said, would allow the Krieger School departments to significantly aug- ment the number and term length of graduate stipends, which support the students’ training as scholars and compensate them for their teaching contributions. Kellee Tsai, vice dean for humanities, social sciences and graduate programs, said that the “generous contribution” will help the school recruit and retain the very best of the next generation of scholars. “The addition of $5 million toward graduate stipends is a testament to the value that President Daniels, Provost [Lloyd] Minor and Dean [Katherine] Newman place on the founding prin- ciple of Johns Hopkins as a research university,” Tsai said. The extra funds will specifically increase the competitiveness of the school’s George E. Owen Fellowships, which the university awards to excep- tionally qualified students, said New- man, the James B. Knapp Dean of the Krieger School. “The presidential con- tribution is a very substantial addition for which we are immensely grateful,” Newman said. “It will help us make our Owen fellowships on par with the awards offered by our toughest competi- tors.” In addition to the funds from the President’s Office, Krieger School funds will be used to enhance a plan already in effect to increase the stipends provided $5 mill from President’s Office will augment funding Continued on page 6 SUPPORT Continued on page 5 2011 Arts Innovation Program grants announced HOMEWOOD B Y H EATHER E GAN S TALFORT JHU Museums and Libraries T he Johns Hopkins University has awarded approximately $24,000 in grants to students and faculty to stimulate new courses in the arts and other arts-related efforts on the Homewood cam- pus, said Winston Tabb, Sheridan Dean of University Libraries and Museums. Initiated in 2006, the Arts Innovation Program offers funding to faculty to create new courses in the arts for undergraduates, with an emphasis on interdisciplinary and cross-divisional courses. The program also supports the artistic efforts of students, both those currently engaged in arts activities and those wishing to create a new venture, with an emphasis on making connections between Johns Hopkins students and the Baltimore community. Four student-proposed arts initiatives will benefit from the funding. Senior history major Shayna Abramson will receive a grant to create an interfaith performing arts program that will produce two short plays during Intersession in Janu- ary 2011. Sophomore history of art major Laura Somenzi, a Woodrow Wilson Fellow, will use the funds to support the publication of a catalog she is writing to accompany her exhibition dedicated to Zelda Fitzgerald that is scheduled to open at the university’s Evergreen Museum & Library in fall 2011. Sophomores Emily Bihl, a Writing Semi- Tan Sri Datuk Dr. Mohan Swami of Chase Perdana and Edward D. Miller of Johns Hopkins shake hands while Tan Sri Dato’ Haji Muhyiddin bin Mohd Yassin, deputy prime minister of Malaysia, and Hillary Clinton, U.S. secretary of state, look on. T he Johns Hopkins University, the Johns Hopkins University School of Medicine and Johns Hopkins Medicine International have signed an agreement with Academic Medical Centre and an associate company of Turiya to help Malaysia develop its first fully integrated private four-year grad- uate medical school and teaching hospital. U.S. Secretary of State Hillary Rod- ham Clinton and Deputy Prime Minister of Malaysia Tan Sri Dato’ Haji Muhyid- din bin Mohd Yassin observed the sign- ing ceremony, which took place Nov. 2 in Kuala Lumpur. Among those representing Johns Hop- CHEE HOE, YAP / ACADEMIC MEDICAL CENTER

description

The official newspaper of The Johns Hopkins University

Transcript of The Gazette

Page 1: The Gazette

111010

OUR 40TH YEAR

Covering Homewood, East Baltimore, Peabody,

SAIS, APL and other campuses throughout the

Baltimore-Washington area and abroad, since 1971.

November 8, 2010 The newspaper of The Johns Hopkins University Volume 40 No. 10

Job Opportunities

Notices

Classifieds

DELICIOUS!

When do carrots taste better

than candy? Psychologists’ find-

ing may surprise you, page 3

RECOGNITION

Young social entrepreneur is

honored for pioneering a new

form of activism, page 7

I N B R I E F

New School of Ed blog; CTY deadline; Sibley

joins JHM; Chili Cook-Off and Bake-Off time

C A L E N D A R

Provost’s Lecture Series: SoN’s Jacqueline

Campbell; Donny Deutsch; Apolo Ohno2 12

Malaysia-bound

Johns Hopkins to help develop medical school and teaching hospitalB Y N A T A L I A A B E L

Johns Hopkins Medicine International Continued on page 10

C O L L A B O R A T I O N

Big boost for KSAS grad stipendsB Y G R E G R I E N Z I

The Gazette

The School of Arts and Sciences will receive more than $5 mil-lion from the President’s Office

over the next five years to fund graduate stipends. President Ronald J. Daniels made the announcement at the Oct.

23 rededication cer-emony of the newly renovated Gilman Hall, the school’s flagship building. The investment, Daniels said, would allow the Krieger School departments to significantly aug-ment the number

and term length of graduate stipends, which support the students’ training as scholars and compensate them for their teaching contributions. Kellee Tsai, vice dean for humanities, social sciences and graduate programs, said that the “generous contribution” will help the school recruit and retain the very best of the next generation of scholars. “The addition of $5 million toward graduate stipends is a testament to the value that President Daniels, Provost [Lloyd] Minor and Dean [Katherine] Newman place on the founding prin-ciple of Johns Hopkins as a research university,” Tsai said. The extra funds will specifically increase the competitiveness of the school’s George E. Owen Fellowships, which the university awards to excep-tionally qualified students, said New-man, the James B. Knapp Dean of the Krieger School. “The presidential con-tribution is a very substantial addition for which we are immensely grateful,” Newman said. “It will help us make our Owen fellowships on par with the awards offered by our toughest competi-tors.” In addition to the funds from the President’s Office, Krieger School funds will be used to enhance a plan already in effect to increase the stipends provided

$5 mill from

President’s

Office will

augment

funding

Continued on page 6

S U P P O R T

Continued on page 5

2011 Arts Innovation Program grants announced H O M E W O O D

B Y H E A T H E R E G A N S T A L F O R T

JHU Museums and Libraries

The Johns Hopkins University has awarded approximately $24,000 in grants to students and faculty to

stimulate new courses in the arts and other arts-related efforts on the Homewood cam-pus, said Winston Tabb, Sheridan Dean of University Libraries and Museums. Initiated in 2006, the Arts Innovation Program offers funding to faculty to create

new courses in the arts for undergraduates, with an emphasis on interdisciplinary and cross-divisional courses. The program also supports the artistic efforts of students, both those currently engaged in arts activities and those wishing to create a new venture, with an emphasis on making connections between Johns Hopkins students and the Baltimore community. Four student-proposed arts initiatives will benefit from the funding. Senior history major Shayna Abramson will receive a grant to create an interfaith

performing arts program that will produce two short plays during Intersession in Janu-ary 2011. Sophomore history of art major Laura Somenzi, a Woodrow Wilson Fellow, will use the funds to support the publication of a catalog she is writing to accompany her exhibition dedicated to Zelda Fitzgerald that is scheduled to open at the university’s Evergreen Museum & Library in fall 2011. Sophomores Emily Bihl, a Writing Semi-

Tan Sri Datuk Dr. Mohan Swami of Chase Perdana and Edward D. Miller of Johns Hopkins shake hands while Tan Sri Dato’ Haji Muhyiddin bin Mohd Yassin, deputy prime minister of Malaysia, and Hillary Clinton, U.S. secretary of state, look on.

The Johns Hopkins University, the Johns Hopkins University School of Medicine and Johns Hopkins Medicine International have signed an agreement with

Academic Medical Centre and an associate company of Turiya to help Malaysia develop its first fully integrated private four-year grad-uate medical school and teaching hospital.

U.S. Secretary of State Hillary Rod-ham Clinton and Deputy Prime Minister of Malaysia Tan Sri Dato’ Haji Muhyid-din bin Mohd Yassin observed the sign-ing ceremony, which took place Nov. 2 in Kuala Lumpur. Among those representing Johns Hop-

CHEE HOE, YAP / ACADEMIC MEDICAL CENTER

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2 THE GAZETTE

I N B R I E F

School of Education launches blog for educators

The School of Education has intro-duced a blog for educators—soetalk .com.

Designed for students, teachers, admin-istrators, policymakers and other interested persons, soetalk.com features articles and opinion pieces addressing policy and leg-islative proposals at the state and national levels, and practices of interest to teachers. The blog provides a forum where educators can express their thoughts on the issues of the day and discuss changes affecting the teaching profession. Among the recent postings: “What Tues-day’s Vote Means for Education,” “Mont-gomery and Prince George’s Boards Face Budget Challenges” and “Early Years to Get More Attention.”

Fall deadline nears for CTY grades 2–8 gifted testing

Nov. 22 is the fall deadline for enroll-ing a gifted child in grades 2 through

-ented Youth Global Talent Search. Enrolled students take above-grade-level tests that can lead to eligibility for CTY’s popular online and summer courses. Enroll-ment by Nov. 22 helps families meet future test deadlines so they can apply to CTY’s 2011 summer program before spaces fill up. Faculty and staff can use tuition remission according to department policies for chil-dren grades 2 through 6 to enroll in CTY’s area day programs and, for older students, at Johns Hopkins and other campuses across the U.S. For more details, go to www.cty.jhu.edu .discover or e-mail [email protected].

Sibley Memorial Hospital joins Johns Hopkins Medicine

In a move to address a growing need for integrated regional health care services for patients, officials of Sibley Memorial

Hospital and The Johns Hopkins Health System signed documents on Nov. 1 to inte-

Hospital into the Johns Hopkins Health System. Under terms of this transaction, which does not involve any financial exchange, Sibley has become a wholly owned subsid-iary corporation of JHHS and a member of Johns Hopkins Medicine. Sibley will retain its commitment to the local community and members of the existing medical staff, along with its name and current leadership and board of trustees. The hospital will now have access to the research and clinical programs at Johns Hopkins. Sibley will operate under the JHHS gov-ernance structure, in the same manner as

Applied Physics Laboratory Michael Buckley, Paulette CampbellBloomberg School of Public Health Tim Parsons, Natalie Wood-WrightCarey Business School Andrew Blumberg, Patrick ErcolanoHomewoodLisa De Nike, Amy Lunday, Dennis O’Shea,Tracey A. Reeves, Phil SneidermanJohns Hopkins MedicineChristen Brownlee, Stephanie Desmon, Neil A. Grauer, Audrey Huang, John Lazarou, David March, Vanessa McMains, Ekaterina Pesheva, Vanessa Wasta,Maryalice YakutchikPeabody Institute Richard SeldenSAIS Felisa Neuringer KlubesSchool of Education James Campbell, Theresa NortonSchool of Nursing Kelly Brooks-StaubUniversity Libraries and Museums Brian Shields, Heather Egan Stalfort

E D I T O R Lois Perschetz

W R I T E R Greg Rienzi

PR O D U C T I O N Lynna Bright

CO P Y ED I T O R Ann Stiller

PH O T O G R A P H Y Homewood Photography

AD V E RT I S I N G The Gazelle Group

BU S I N E S S Dianne MacLeod

CI R C U L AT I O N Lynette Floyd

WE B M A S T E R Tim Windsor

C O N T R I B U T I N G W R I T E R S

The Gazette is published weekly Sept-ember through May and biweekly June through August for the Johns Hopkins University community by the Office of Government, Community and Public Affairs, Suite 540, 901 S. Bond St., Baltimore, MD 21231, in cooperation with all university divisions. Subscrip-tions are $26 per year. Deadline for calendar items, notices and classifieds (free to JHU faculty, staff and students) is noon Monday, one week prior to publication date.

Phone:Fax:General e-mail: [email protected] e-mail: [email protected] the Web: gazette.jhu.edu

Paid advertising, which does not repre-sent any endorsement by the university, is handled by the Gazelle Group at 410-343-3362 or [email protected].

The Johns Hopkins Hospital, Johns Hopkins Bayview Medical Center, Howard County General Hospital and Suburban Hospital. “As a member of Johns Hopkins Medi-cine, Sibley will be a key force in the development of an integrated system of care for the national capital region, focused on improving health by providing access to state-of-the-art clinical medicine that’s sup-ported by a strong base of research and medi-cal education,” said Edward D. Miller, dean of the Johns Hopkins School of Medicine and CEO of Johns Hopkins Medicine.

Cellist Gautier Capucon, pianist Gabriela Montero to perform

Cellist Gautier Capucon, the 2001 Victoires de la Musique New Talent of the Year, and acclaimed pianist

Gabriela Montero will perform in the Shriv-er Hall Concert Series’ annual Piatigorsky Memorial Concert at 5:30 p.m. on Sunday, Nov. 14, in Shriver Hall auditorium on the Homewood campus. The duo will play Prokofiev’s Cello and Piano Sonata in C Major, Op.119, Men-delssohn’s Cello and Piano Sonata No. 2

Piano Sonata in A Minor, Op. 36. Capucon last appeared in the series in January 2006, with his violinist brother Renaud. This is Montero’s series debut. The performers were introduced in Lugano, Switzerland, by famed pianist Mar-tha Argerich, and a great friendship and musical partnership were born: Rhapsody, the duo’s CD of works by Rachmaninoff and

For more information or to order tickets, go to www.shriverconcerts.org or call 410-

Chili Cook-Off and Bake-Off set for Friday at Homewood

The eighth annual Chili Cook-Off and Bake-Off to benefit the JHU Campaign for United Way of Cen-

tral Maryland and the Johns Hopkins Neighborhood Fund will be held from 11:30 a.m. to 1:30 p.m. on Friday, Nov. 12, in Levering’s Glass Pavilion on the Home-wood campus. The deadline for entering is 5 p.m. today,

-ter, go to web.jhu.edu/uw and click on the Special Events link for a Chili Cook-Off registration flier, or call the Office of Work,

Guest judges will award prizes for first-, second- and third-place winners, and a People’s Choice Award, based on the popu-lar vote, will be given out in each category. In addition to sampling the chili and baked goods cooked by colleagues, specta-tors will be able to purchase lunch—chili, cornbread, dessert and a beverage—for $5.

Aubrey Pevsner and Mike Alfieri as May and Eddie

JOHN ASTIN

B Y A M Y L U N D A Y

Homewood

The Johns Hopkins University The-atre will present Sam Shepard’s Fool for Love for two weekends beginning

on Friday, Nov. 12, in the Merrick Barn on the Homewood campus. Considered a 20th-century American clas-sic, Fool for Love is set in a seedy motel on the edge of the Mojave Desert, where tran-sient lovers May and Eddie spin around the room in a relentless struggle for power and truth. Through recollections and dreams, multiple versions of their fierce and fatal love story are told. The cast of undergraduate performers includes Aubrey Pevsner, a sophomore in the Writing Seminars; Mike Alfieri, a senior in the Writing Seminars; Gaurav Dhar, a sophomore majoring in biophysics; and

Kelly McNamara, a senior majoring in biol-ogy. The cast is directed by James Glossman, who is teaching Directing Seminar this semester in the Program in Theatre Arts and Studies. The production will run through Sunday,

-days and Saturdays and 2 p.m. on Sundays. Tickets are $5 for students with ID, $13 for faculty, staff and seniors (65+) and $15 for the general public, cash or check only. For reservations and information, call 410-516-5153 or e-mail [email protected]. The the-ater’s website is www.jhu.edu/theatre-arts. The Johns Hopkins University Theatre is celebrating its sixth full season in the historic Merrick Barn. The program and the theater company are directed by actor John Astin, a Johns Hopkins alumnus. Astin recently performed in Ken Ludwig’s play Leading Ladies at Ford’s Theatre in Washing-ton, D.C.

JHUT presents Sam Shepard’s ‘Fool for Love’

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GAZETTE 3

B Y L I S A D E N I K E

Homewoood

It’s commonly accepted that we appreci-ate something more if we have to work hard to get it, and a study by Johns Hop-

kins psychologists bears that out, at least when it comes to food. The study seems to suggest that hard work can even enhance our appreciation for fare we might not prefer, such as the low-fat, low-calorie variety. At least in theory, this means that if we had to navigate an obstacle course to get to a plate of baby carrots, we might come to prefer those crunchy crudites over the sweet, gooey Snickers bars more easily accessible via the office vending machine. “Basically, what we have shown is that if you have to expend more effort to get a certain food, not only will you value that food more, but it might even taste better to you,” said Alexander Johnson, an associate

research scientist in the Department of Psy-chological and Brain Sciences in the Krieger School of Arts and Sciences. “At present, we don’t know why effort seems to boost the taste of food, but we know that it does, and that that effect lasts for at least 24 hours after the act of working hard to get the food.” The results of the study, which appears in the Nov. 3 issue of the Proceedings of the Royal Society B, are significant not only because they hold out hope that people who struggle to maintain a healthy weight could be con-ditioned to consume lower-calorie foods but because they also might provide insight into methods of changing other less-than-optimal behavior, according to Johnson. Johnson teamed up on the project with Michela Gallagher, Krieger-Eisenhower Pro-fessor of Psychological and Brain Sciences and Neuroscience and vice provost for aca-demic affairs at Johns Hopkins. Using ordi-nary laboratory mice, the team conducted two experiments.

Food tastes better when you work hard for it, study shows In the first, mice were trained to respond to two levers. If the mice pressed one lever once, they were rewarded with a sugary treat. Another lever had to be pressed 15 times to deliver a similar snack. Later, when given free access to both tidbits, the rodents clearly preferred “the food that they worked harder for,” Johnson said. In the second experiment, the team wanted to find out whether the animals’ preference for the harder-to-obtain food would hold if those morsels were low-calorie. So half the mice received lower-calorie goodies from a high-effort lever, and half got them from a low-effort lever. When both groups of mice were given free access to the low-calorie food later, those who had used the high-effort lever ate more of it and even seemed to enjoy it more than did the other group. “We then analyzed the way in which the mice consumed the food,” Johnson said. “Why did we do this? Because food intake can be driven by a variety of factors, includ-

ing how it tastes, how hungry the mice were beforehand and how ‘sated’ or full the food made them feel.” Johnson and Gallagher used licking behav-ior as a measure of the rodents’ enjoyment of their treats and found that the mice that had to work harder for their low-cal rewards did, in fact, savor them more. “Our basic conclu-sion is that under these conditions, having to work harder to get a certain food changes how much that food is valued, and it does that by changing how good that food tastes,” Johnson said. “This suggests that, down the road, obese individuals might be able to alter their eating habits so as to prefer healthier, low-calorie food by manipulating the amount of work required to obtain the food. Of course, our study didn’t delve into that aspect. But the implications certainly are there.” The study was funded by grants from the National Institute of Diabetes and Digestive and Kidney Diseases and the National Insti-tute of Mental Health.

Overweight American children and adolescents have become fatter over the last decade, according to

researchers at the Johns Hopkins Bloomberg School of Public Health and the National Institute on Aging. Examining adiposity shifts across socio-demographic groups over time, they found that U.S. children and adolescents had sig-nificantly increased adiposity measures such as body mass index, waist circumference and triceps skinfold thickness. The increases in adiposity were more pro-nounced in some sex-ethnic groups, such as black girls. In addition, these groups gained more abdominal fat over time, which was indicated by waist size and which posed greater health risks than elevated BMI. The researchers’ results are featured in the

August issue of the International Journal of Pediatric Obesity. “Our analysis shows that the increase in adiposity among U.S. children and ado-lescents was unequally distributed across sociodemographic groups and across the spectrum of BMI, waist circumference and triceps skinfold thickness measures,” said Youfa Wang, senior author of the study and an associate professor in the Bloomberg School’s Department of International Health. “Heavier children and adolescents gained more adiposity, especially waist size, and these findings were most significant among children ages 6 to 11. “Ethnic disparities in mean BMI have also increased substantially when compar-ing black girls with their white counterparts for all ages combined,” he said. “Solely

Overweight American children, adolescents becoming fatterexamining the changes in the prevalence of overweight and obesity based on fixed BMI cut points could not gain such important insights regarding shifts in the obesity epi-demic.” To examine these changes over time, researchers conducted a comprehensive analysis of nationally representative survey data collected from the National Health and Nutrition Examination Survey since the

American boys and girls ages 2 to 19, as well as by ethnic groups at the population level. “Our research suggests that U.S. young people may be at greater obesity-related risks than what was revealed by increases in BMI, as waist circumference is a better predictor of future health risks, such as for type 2 diabetes and heart disease in adults,”

said May A. Beydoun, a staff scientist with the National Institute on Aging’s Intramural Research Program and a former postdoctoral fellow in the Bloomberg School’s Depart-ment of International Health. “More vigor-ous efforts should be made to understand the underlying causes. Moving forward, this could help guide future population-based interventions, including those focusing on the total population and those targeting vul-nerable or genetically susceptible groups,” she said. The study was written by Beydoun and Wang. The research was supported by the National Institute of Diabetes and Digestive and Kidney Diseases and by the National Institute on Aging.

—Natalie Wood-Wright

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Page 4: The Gazette

4 THE GAZETTE

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Programs begin promptly at start times.

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Over the past five years, 75% of Park School students taking Advanced Placement exams in Calculus AB and Calculus BC scored 5, the highest possible score.

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Page 5: The Gazette

GAZETTE 5

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Continued from page 1

Artsnars and English major with a minor in film and media studies, and Hannah Froehle, an international relations and German major, will organize the project LBD: Liberation by Design under the auspices of the Digital Media Center. Fifteen artists and students will personalize basic black wrap dresses that will be shown in a fashion show and auc-tioned off for charity during the university’s

10, 2011. Political science and anthropology sopho-more Anna Zetkulic will organize the Hop-kins Clay Initiative, a service-based program specializing in the art of pottery. The new group of student potters will create ceramic objects that will be sold to benefit Baltimore social service organizations. Additionally, three new courses will receive support. In spring 2011, Phyllis Berger, photog-raphy instructor in the Homewood Art Workshops, and Lester K. Spence, assistant professor of political science and Africana studies in the Krieger School, will teach Black Visual Politics, an interdisciplinary course in which students will address the politics of black families, the black self and black spaces in conjunction with visual analysis of related photographic images. The results of their study will culminate in indi-vidual photographic portfolios that will be displayed during the arts festival in April. In Introduction to Computer Music, stu-

dents will explore electronic music as a long-standing art form, and create original musical works by recording and manipulat-ing sound on computers. This lecture and lab course will be taught in fall 2011 by Ste-phen C. Stone, chair of the Music Theory Department at the Peabody Conservatory; composer Mark A. Lackey, adjunct professor at the Peabody Conservatory; and sound art-ist Rose Burt, audio specialist at the Digital Media Center. Also to be offered in fall 2011 is Halls of Wonder: Art and Culture in the Age of

with the Walters Art Museum led by Earle

Havens, curator of early books and manu-scripts at the university’s Sheridan Libraries; Walter Stephens, the Charles S. Singleton Professor of Italian, German and Romance Languages and Literatures at Johns Hopkins; and Joneath Spicer, the James A. Mur-naghan Curator of Renaissance and Baroque Art at the Walters. Students will examine how collections of art and cultural artifacts were created, interpreted and represented to the wider world during the pre-modern era. Their research will culminate in an interac-tive, digital display to accompany the Hall of Wonders permanent exhibition at the Walters Art Museum. G

B Y E K A T E R I N A P E S H E V A

Johns Hopkins Medicine

Babies born to mothers who eat peanuts during pregnancy appear more prone to peanut allergy, according to research

conducted by scientists at Johns Hopkins Children’s Center and elsewhere and pub-lished online Oct. 29 in The Journal of Allergy and Clinical Immunology. The research team was led by Scott Sicherer, of the Mount Sinai School of Medicine in New York. The researchers analyzed the relationship between maternal peanut-eating habits dur-ing pregnancy and a child’s sensitivity to peanut proteins. Infants in the study whose mothers reported eating peanuts at least twice a week during pregnancy were nearly three times more likely than other infants to have levels of peanut antibodies high enough to suggest a lurking peanut allergy.

Of the 503 infants, 3 to 15 months of age,

already had either confirmed or suspected diagnoses of milk or egg allergy. The investigators emphasize that their work is far from showing a direct cause and effect between a mother’s peanut consump-tion and her baby’s allergy, and that the affected babies were already more likely to be immunologically susceptible to peanut allergies. The findings do suggest, however, that peanut eating may be a “priming” mechanism—possibly one of several such mechanisms—for developing peanut allergy, the investigators say. “Mom’s peanut consumption during preg-nancy appears to be a key primer for allergy in babies who already have the immuno-logic predisposition for such, but eating pea-nuts in and of itself is not enough to cause the allergy,” said Robert Wood, co-author on the study and director of Allergy and

Expectant moms and peanuts: Maybe not a good ideaImmunology at Johns Hopkins Children’s Center. Indeed, the fact that the children in the study were already allergic to other foods suggests a predisposition to allergies, the investigators emphasize. While the scientists stop short of recom-mending complete peanut avoidance during pregnancy, their findings suggest that preg-nant women should keep this risk factor in mind when making dietary choices, especially if they have a family history of food allergies. The investigators also caution that ele-vated antibody levels are not the same as clinical allergy, even though they are believed to be a potent predictor of future allergies. A food challenge remains the gold standard for clinical allergy, but because of the infants’ young age, such tests were not performed, the investigators say. Among the 211 children whose moth-ers reported eating peanuts at least twice a week, 35 percent had significantly elevated

antibodies to peanuts, while 22 percent of the 292 infants whose moms consumed pea-nuts less than twice a week had such high levels. Whether a mother ate peanuts during breastfeeding did not seem to affect a child’s risk for peanut allergy, nor did the mode of delivery, whether the baby was breast- or formula-fed or whether a baby was fed soy or milk formula, the researchers found. An estimated 1 percent of U.S. children have peanut allergies, which are often life-long. Past research suggests that peanut allergies are more severe than other food allergies. Institutions participating in the study in addition to Mount Sinai and Johns Hop-kins were Duke University Medical Center, National Jewish Health Hospital and the University of Arkansas for Medical Sciences. The research was funded by the National Institutes of Health.

B Y M A R Y A L I C E Y A K U T C H I K

Johns Hopkins Medicine

When cells make the proteins that carry out virtually every function of life, it’s vital that the right

things happen at the right times, and—may-be more important—that wrong things are stopped from happening at the wrong times. Now Johns Hopkins scientists have found that a structure inside a cell’s protein-making machinery performs an unexpected negative “enforcer” function in addition to its known “positive” roles as protector and promoter of protein production. The research, which focuses on the odd chemical “cap” of mes-senger RNA, is described in the Sept. 24 issue of Molecular Cell. The team revealed that the cap—a baroque structure made of modified RNA constituents joined head-to-head rather than the usual head-to-tail arrangement found in the rest of the messenger RNA—prevents the manufacture of faulty proteins early on, at the very start of the complex

process of protein manufacture, when mes-senger RNA delivers the genetic code from DNA to the decoding machine, which later translates it into proteins. The team began its study in yeast by separating out all the various parts of the protein-making machinery. The scientists then modified some messenger RNA by lopping off its chemical cap and left the rest intact so that when they reconstituted the machine in test tubes, they could compare the behaviors of capped and uncapped ver-sions of messenger RNA. Because they added a radioactive atom to the messenger RNA and fluorescent tags to the other proteins required for protein manufacture, the researchers could evaluate mRNA recruitment under various condi-tions—with and without a cap, for instance, and in the presence and absence of various other factors. Because the cap was known to play two positive roles in the protein-manufacturing process, the researchers were surprised to see that the capless mRNA bound even better than the capped mRNA to protein builders called ribosomes.

Positively negative: Cellular structure’s ‘enforcer’ role discovered “This was strange because the cap of messenger RNA is supposed to be both a stabilizer and a stimulator of binding,” said Jon Lorsch, a professor of biophysics and biophysical chemistry in the Johns Hopkins University School of Medicine. Further studies revealed that when the cap was removed, the mRNA bound efficiently but indiscriminately, even when all the other necessary proteins were not present. In this case, normal proteins could not be made. The cap appears to prevent the mRNA from interacting with the ribosome unless all the required proteins are present and accounted for, according to Lorsch. When all the factors are present, the cap stimulates binding. When they aren’t there, the cap inhibits binding. “The cap is an enforcer,” Lorsch said, “and the only pathway it’s going to allow the mRNA down is the right one. It’s prevent-ing it from going down this wrong pathway that leads to aberrant products.” The work offers evidence, Lorsch said, that “biology is maybe more about prevent-ing the negatives from happening than about promoting the positives.

“The key,” he said, “is keeping all the many possible incorrect complexes from forming so that the right one can be made. If you think about diseases such as sickle cell anemia, Alzheimer’s and cancer, they are examples of the wrong things taking place when they shouldn’t; they indicate a break-down in prevention mechanisms.” The study was supported by the National Institute of General Medical Sciences. Johns Hopkins authors of the study, in addition to Lorsch, are Sarah F. Mitchell, Sarah E. Walker and Mikkel A. Algire. Other authors are Eun-Hee Park and Alan G. Hinnebusch, both of the National Insti-tute of Child Health and Human Develop-ment.

Page 6: The Gazette

6 THE GAZETTE

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to current students, Newman said, whether Owen fellows or not. “All of our doctoral students are outstand-ing and deserving of our support,” she said. “These colleagues represent the future of the academy and many professions, and it takes years of hard work and devotion to be able to do high-quality independent scholar-ship.” Newman said that she, the vice deans and the department chairs will think through the most useful ways to craft the school’s graduate funding “packages,” a process that will take at least a month. The extra stipend funds will be available soon, Newman said, so that their impact can be immediate and have a positive impact on

Continued from page 1

Stipends the upcoming recruitment season. They will be distributed by the Dean’s Office to the Krieger School departments, which decide on the awardees. The School of Arts and Sciences cur-

counting those enrolled in Advanced Aca-demic Programs). Newman said that it is exceedingly diffi-cult to find sources of philanthropic support for doctoral students, with some notable exceptions, including Johns Hopkins alumni and institutions such as the Andrew Mellon Foundation, the National Science Founda-tion, the Soros Foundation for New Ameri-cans, the National Institutes of Health and a set of foundations that provide research funding for dissertations. The lion’s share of responsibility for graduate support, she said, comes from within the university for the humanities and social sciences, as well as from research grants, primarily in the natural and social sciences.

B Y E K A T E R I N A P E S H E V A

Johns Hopkins Medicine

Research conducted at the Johns Hop-kins Children’s Center and elsewhere shows that regardless of the type of

treatment they get, nearly half of severely depressed teens who recover from a depres-sive episode are likely to slip back into depression within two to three years. The findings of the multicenter NIH-funded study, which appears in the Novem-ber issue of JAMA-Archives of General Psychi-atry, show that nearly all (96 percent) of the 196 teenagers in the research group either improved or fully recovered after an initial

them had one or more subsequent depressive episodes in an average of two years. Much to the investigators’ surprise, they said, the type of treatment received made no difference in terms of recurrence. Indeed, teens treated with a combination of medi-cation and cognitive behavioral therapy appeared just as likely to suffer subsequent depressive episodes (49 percent of them did) as those who received either treatment alone (46 percent). Two potent predictors of recurrence did emerge: being female and showing no response to treatment at all. For reasons that are not clearly understood, the researchers said, girls were more likely to have repeated bouts of depression, with nearly 60 percent of them suffering subsequent depressive epi-sodes after recovery, compared to 33 percent of the boys. Teens who showed no improve-

but who subsequently recovered were also more likely to have subsequent episodes of

43 percent among those who responded to treatment either fully or in part. The findings highlight a need for long-term follow-up and rigorous monitoring of symptoms among depressed teens, even when they seem to be on the mend, the investigators said. “To ward off more bouts of depression and to recognize and treat them promptly if they do occur, parents, pediatricians and mental health professionals should view childhood

depression as a chronic condition marked by remissions and flare-ups,” said researcher Golda Ginsburg, a psychologist at the Johns Hopkins Children’s Center and an associate professor of psychiatry at the Johns Hopkins University School of Medicine. Symptoms should be monitored carefully and therapy frequency and medication dos-age adjusted as needed in all teens diagnosed with depression, Ginsburg said. Because nearly all teenagers recovered within two years of starting treatment, the results are far from discouraging, the researchers said, indicating that while not long-lasting, the therapy is highly effective in the short term. But the findings, they said, hint at the need to identify treatments that reduce recurrences and improve long-term recovery. The new results are based on a three-and-a-half-year follow-up of 196 teens who participated in an earlier seminal study, published in JAMA in 2004, comparing outcomes among 439 teens with depression treated with medication, cognitive behav-ioral therapy, a combination of the two or placebo. At three months, teens receiving the combination treatment had the best response, but after nine months and after one year, the three treatments resulted in similar outcomes. Three months into the original study, those receiving placebo got the treatment of their choice. Depression, which in the United States affects an estimated 6 percent of teen girls and nearly 5 percent of teen boys, can lead to impaired school performance and social functioning, adult depression and suicide. The research was funded by the National Institute of Mental Health. John Curry, of Duke University, was the lead author on the paper. Elizabeth Kastelic, of the Johns Hopkins Children’s Center, was co-investigator. Institutions participating in the study in addition to Johns Hopkins and Duke were the Oregon Research Institute, University of Nebraska Medical Center, University of Texas-Southwestern, Columbia Univer-sity Medical Center, Cincinnati Children’s Medical Center, Case Western Reserve Uni-versity, University of Oregon and Children’s Hospital of Philadelphia.

One in two depressed teens prone to recurrence after recovery

G

GIVEBLOOD.

A JHU Blood Drive is scheduled forWed., Nov. 10, at Hopkins@Eastern, 101 E. 33rd St.,

from 8:30 a.m. to 1 p.m.

For more information, e-mail [email protected]

Page 7: The Gazette

GAZETTE 7

B Y A M Y L U N D A Y

Homewood

Jacob Colker, a graduate student in the Communications in Contemporary Society program in the Krieger School’s

Advanced Academic Programs, is among the first group of young social entrepreneurs to be honored by the Rolex Awards for Enterprise: Young Laureates Programme. On Thursday, Nov. 11, Colker and four other winners will be feted for their dedica-tion to overcoming challenges in the fields of public health, applied technology, the environment and cultural preservation at an award ceremony at the Ecole Polytechnique Federale de Lausanne in Switzerland. Colker is the only laureate from the United States; the others are from the Philippines, Nigeria, India and Ethiopia. Colker, who is 26, is being recognized for changing the way people get involved in community service as co-founder of the Extraordinaries, an Internet-based program allowing “microvolunteers” to use their skills and expertise online. Their flagship product is free and available to the public at www .sparked.com. The Young Laureates Programme seeks to foster a spirit of enterprise in the next gen-eration by giving young people the finan-cial support and recognition they need to innovatively tackle the challenges facing humanity. The laureates, all aged between

two years, giving them time to focus on their

pioneering projects and move forward in implementing them. Colker said he will use his Rolex Award to expand microvolunteering to more Internet users and gain publicity to “encourage mil-lions of people to volunteer.” Colker’s project combines volunteering, the Internet and mobile phones to pioneer a new form of activism in which almost any-one with a smart phone or Web access can devote spare time to a useful charitable or

Young social entrepreneur makes spare minutes matter

scientific task. More than 40,000 microvol-unteers have signed up to carry out a wide range of tasks, from helping the SETI Insti-tute develop social media outreach materials to helping village leaders in Kenya research grant opportunities for new hospitals. Through the www.sparked.com website, nonprofit groups can easily post questions, problems or tasks, and thousands of micro-volunteers can read the posts to offer assis-tance. Volunteers may select from 12 areas

of interest, including poverty, youth, injus-tice, food, politics and animals, and then decide which personal skills they will use in their spare time to help solve problems posted there. “For the most part, traditional volunteer opportunities require a certain level of com-mitment. They require a commitment of time,” Colker said in a video posted on Rolex’s Young Laureates website, young.rolexawards .com. “Our approach is to help make it so easy that in the same amount of time it takes you to check Facebook or watch a You-Tube video, you could actually do something worthwhile in that same five- or 10-minute chunk of time.” A notable success for the project came in January 2010, in the aftermath of the mas-sive earthquake in Haiti. From its headquar-ters in San Francisco, the Extraordinaries

enabling its volunteers to compare photos of missing people to photos taken by news agencies. The volunteers identified 24 of the missing people. Colker said, “It was just an incredible moment, realizing, Wow, we actually found missing persons using this technology that didn’t exist before. If we can help people realize that doing good is as easy as click-ing a mouse or typing a few sentences on a keyboard, my hope is that at its scale, we will have millions of people sharing their skills and expertise and helping to move humankind forward. That’s a big goal, but that’s what we wake up every single day and try to do.”

R E C O G N I T I O N

Jacob Colker will be honored with a Rolex Award for his project that combines vol-unteering, the Internet and mobile phones to pioneer a new form of activism.

BART MICHIELS / ROLEX AWARDS

B Y S T E P H A N I E D E S M O N

Johns Hopkins Medicine

Just as with everyone else perhaps, the more hours surgeons work, and the more nights they spend on call each week, the

more likely they are to face burnout, depres-sion, dissatisfaction with their careers and serious work-home conflicts, according to a major new study led by Johns Hopkins and Mayo Clinic researchers. Yet a forced reduction in work hours may not be the solution for even the busiest surgeons, who could resent punching a time clock. The study, published in the November issue of the Journal of the American College of Surgeons, showed a strong connection between increasing hours and nights on call and a detrimental psychological impact on surgeons in almost every setting, both pro-

fessionally and personally. “Increasing hours and nights on call results in surgeon distress using every vari-able we have,” said Charles M. Balch, a professor of surgery at the Johns Hopkins University School of Medicine and the study’s lead author. “There’s a strong correla-tion between workload and distress, which comes out in the personal and professional lives of surgeons.”

across the nation. Of surgeons working

the survey’s criteria for burnout, 39 percent were screen-positive for depression, and 11 percent reported that they had made a sig-nificant medical error in the previous three months. One in five surgeons who worked

not become a surgeon again if they had the choice today.

Long hours + multiple nights on call = surgeon burnout Despite the evidence linking a heavy workload with many types of distress, Balch and his colleagues do not advocate restric-tions on work hours. “While there is evidence that burnout can lead to problems, there is no evidence that reducing hours would make all doctors more satisfied or lead to better patient care,” Balch said. “If hours were regulated, the real-ity is that people would have to punch time clocks, and I don’t think surgeons necessar-ily want their workload monitored.” The key, Balch suggested, is more atten-tion to earlier identification of surgeons at higher risk for burnout problems. In the survey, two-thirds of surgeons, even

week or were on call more than three nights a week, said they did not want limits put on their hours. Surgeons who were salaried were more likely to favor restrictions than those whose pay was based entirely on billing.

Balch said he hopes that his research draws attention to the issues facing surgeons who work long hours who are also at risk for personal consequences such as addiction, early retirement and even suicide. “Part of it is just trying to get this issue of personal wellness on people’s radar screens,” he said. Surgeons and their supervisors, he added, should use the data to identify candidates for counseling or tailored schedules to address individual concerns. “Burnout has no single simple cause, and therefore there’s not going to be a simple solution,” he said. The American College of Surgeons recently began a second study of burnout and related issues. The new data, Balch said, should pro-vide a clearer picture about these associations between workload and surgeon distress. Julie A. Freischlag, director of the Depart-ment of Surgery at Johns Hopkins, was the senior investigator on the study.

B Y T I M P A R S O N S

Bloomberg School of Public Health

All-terrain vehicles are associated with a significant and increasing number of hospitalizations for children in

the United States, according to a new report by the Center for Injury Research and Policy at the Johns Hopkins Bloomberg School of Public Health.

hospitalizations for ATV injuries increased

years, with important demographic varia-tions. Rates increased most dramatically in the South and Midwest, and among teens

-

the sharpest rise in ATV hospitalizations over the study time period, an increase of

250 percent. The report is published in the October issue of the Journal of Trauma. “All-terrain vehicles are inherently dan-gerous to children,” said Stephen M. Bow-man, assistant professor with the Johns Hopkins Center for Injury Research and Policy and the report’s lead author. “While manufacturers are required to label vehicles with engine sizes greater than 90cc as inap-propriate for children younger than 16, our data indicate that a growing number of children are receiving serious injuries due to ATV use, suggesting that parents are unaware of these recommendations or are choosing to ignore them.”

Commission and representatives of the ATV industry entered into a decade-long consent decree to reduce the risk of injury associated with ATV use; provisions included a ban on the sale of three-wheeled ATVs, a free nationwide training program for all ATV

Pediatric hospitalizations for ATV injuries more than doublepurchasers, improved safety labeling and a public awareness campaign. This consent

by only some manufacturers on a voluntary basis. While previous studies have examined the impact of the expiration of the con-sent decree between the Consumer Product Safety Commission and the ATV industry immediately following its termination, this is the first study to examine whether rates of ATV-injury hospitalizations have continued to increase. “Clearly, too many children are being injured on these vehicles,” said Mary E. Ait-ken, professor of pediatrics with the Arkan-sas Children’s Hospital and a co-author of the report. “Given the dramatic increases in hospitalization that we report, a renewed effort by the public health community, the ATV industry and the [Consumer Product Safety Commission] to address this problem is warranted.”

The researchers analyzed hospital dis-charge data from the Kid’s Inpatient Data-base of the Healthcare Cost and Utilization Project, which is sponsored by the Agency for Healthcare Research and Quality. Injury Severity Scores, a widely accepted mea-sure of injury severity, were calculated for each hospitalization. Results showed that all types of injury (minor, moderate and major) increased over the study time period, with rates for hospitalizations with moderate to severe traumatic brain injury tripling. “In our study, 30 percent of patients hospitalized for ATV-related injuries had a diagnosis of traumatic brain injury,” Bow-man said. “Increasing helmet use through a combination of policy and education is critical to curbing the increasing trend in ATV-related hospitalizations among chil-dren.” Support for this research came from the Arkansas Biosciences Institute.

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8 THE GAZETTE

Page 9: The Gazette

GAZETTE 9

Continued from page 12

Calendar N O V . 8 – 1 5

Modifier,” a Biophysics and Bio-physical Chemistry seminar with Christopher Lima, Sloan Ketter-

EB

Wed., Nov. 10, 2 p.m. “Sequence-Influenced Methyla-tion Polymorphism,” an Institute of Genetic Medicine seminar with Andrew Chess, Center for Human Genetic Research of Harvard Medical School and Massachu-setts General Hospital. Mount-castle Auditorium, PCTB. EB

Wed., Nov. 10, 3 p.m. “Direc-tionally Freeze-Cast Titanium Foams,” a Materials Science and Engineering seminar with David Dunand, Northwestern Univer-sity. 110 Maryland. HW

Wed., Nov. 10, 3 p.m. “Struc-tural Insight Into Mitochondrial Protein Import,” a Cell Biolo-gy seminar with Toshiya Endo, Nagoya University, Japan. Room

EB

Wed., Nov. 10, 3:45 p.m. “Using Joint Longitudinal-Surviv-al Models for Individual Predic-tion and Estimation of Treatment Effects,” a Biostatistics seminar with Jeremy Taylor, University of Michigan School of Public Health. W2030 SPH. EB

Wed., Nov. 10, 4 p.m. “Epi-

genetic Control of Cell Cycle Checkpoint and Invasion and Its Implication in Cancer Therapy,” a Pharmacology and Molecular Sciences seminar with James Hsieh, Memorial Sloan Ketter-ing Cancer Center. West Lecture Hall (ground floor), WBSB. EB

Thurs., Nov. 11, 10:45 a.m. “Meaning Propagation,” a Com-puter Science seminar with Fer-nando Pereira, University of

HW

Thurs., Nov. 11, noon. “Target-ing Oncogenic PIK3CA Muta-tions for Breast Cancer Therapy,” a Cell Biology seminar with Ben Ho Park, SoM. Room 2-200,

EB

Thurs., Nov. 11, 1:30 p.m. “Graph Metrics and Dimension Reduction,” an Applied Mathe-matics and Statistics seminar with Minh Tang, WSE. 304 White-head. HW

Thurs., Nov. 11, 3 p.m. The Bromery Seminar—“A New Hydrologic and Historical Assess-

Flood” with Neil Coleman, Car-rie Davie-Todd and Uldis Kak-tins, University of Pittsburgh. Sponsored by Earth and Plan-etary Sciences. 305 Olin. HW

Thurs., Nov. 11, 3 to 7 p.m., and Fri., Nov. 12, 9 a.m. to 1

p.m. The Futures Seminar—An-thropology, with Arjun Appa durai and Matt Canfield, NYU; Bhrigu-pati Singh and Steven Caton, Har-vard University; Sameena Mulla, Marquette University; Xiao-bo Yuan, University of Chicago; and Jennifer Culbert, KSAS. Mason Hall Auditorium (Thursday) and Salon B, Charles Commons Con-ference Center (Friday). HW

Thurs., Nov. 11, 3:30 p.m. “The Nature of Molecular Inno-vations at the Origin of Eukary-otes,” a Molecular Biology and Genetics seminar with Eugene Koonin, NCBI, NLM and NIH. WBSB Auditorium. EB

Thurs., Nov. 11, 4 p.m. “The Value of Humanity,” a Political and Moral Thought seminar with Sarah Buss, University of Michi-gan. Sponsored by Philosophy.

HW

Fri., Nov. 12, 11 a.m. “Bac-terial or Cellular Microrobot-ics for Biofactory-on-a-Chip,” a CEAFM seminar with Minjun Kim, Drexel University. 110 Maryland. HW

Fri., Nov. 12, 1:30 p.m. “Inner Workings of an ATP-driven DNA Damage Sensor,” a Biophysics and Biophysical Chemistry seminar with David Jeruzalmi, Harvard

EB

Fri., Nov. 12, 4 p.m. “Steer-

ing Forces in Protein Folding: Looking Behind the Curtain,” a Biophysics thesis defense seminar with Lauren Porter. 111 Mergen-thaler. HW

Mon., Nov. 15, noon. “Struc-tures of Ribonucleoprotein Par-ticles That Make Ribosomes, Spliceosomes and Telomerase,” a Biophysics seminar with Hong Li, Florida State University. 111 Mer-genthaler. HW

Mon., Nov. 15, 12:15 p.m. “Cel-lular and Molecular Mechanisms Regulating Epithelial Branch-ing Morphogenesis and Cancer Invasion,” a Carnegie Institution Embryology seminar with Andrew Ewald, SoM. Rose Auditorium, 3520 San Martin Drive. HW

Mon., Nov. 15, 1 p.m. “Obesity and Glycemic Measures Among HIV-infected Injection Drug Users,” an Epidemiology the-sis defense seminar with Akosua

SPH. EB

Mon., Nov. 15, 2 p.m. “Statisti-cal Analysis of Cross-Sectional Survival Data With Applications to the Study of Dementia,” a Bio-statistics thesis defense seminar with Marco Carone. E9519 SPH. EB

Mon., Nov. 15, 3:30 p.m. “Promising Environmental Strate-gies to Prevent and Reduce Men-tal Health Disparities,” a Center for Health Disparities Solutions seminar with Debra Furr-Holden, SPH. Sponsored by Health Policy and Management. B14B Hampton House. EB

Mon., Nov. 15, 4 p.m. “The Race of Fascism: Je Suis Partout, Race and Culture,” a History semi-

nar with Sandrine Sanos, Texas -

man. HW

S P E C I A L E V E N T S

Tues., Nov. 9, 8 p.m. 2010 Mil-ton S. Eisenhower Symposium—The Global Network: America’s Changing Role in an Interconnect-ed World, with legendary adman Donny Deutsch. (See photo, p. 12.) Talk followed by question-and-answer session and recep-tion. Shriver Hall Auditorium. HW

Fri., Nov. 12, 11:30 a.m. to 1:30 p.m. The eighth annual Chili Cook-off and Bake-off to benefit the JHU Campaign for United Way of Central Maryland and the Johns Hopkins Neighbor-hood Fund. (See In Brief, p. 2.) Glass Pavilion, Levering. HW

T H E A T E R

Fri., Nov. 12, and Sat., Nov. 13, 8 p.m., and Sun., Nov. 14, 2 p.m. Johns Hopkins University Theatre presents Sam Shepard’s Fool for Love. (See story, p. 2.) $15 general admission; $13 for senior citizens, JHU faculty, staff and retirees; $5 for students with ID. Merrick Barn. HW

W O R K S H O P S

Tues., Nov. 9, 1:30 p.m. “Eyes on Teaching: Evaluation to Improve Instruction,” a Center for Edu-cational Resources workshop for faculty, postdocs and graduate stu-dents only. Registration required; go to www.cer.jhu.edu. Garrett Room, MSE Library. HW

B Y D A V I D M A R C H

Johns Hopkins Medicine

Scientists at Johns Hopkins have taken a less-is-more approach to designing effective drug treatments that are pre-

cisely tailored to disease-causing pathogens, such as viruses and bacteria, and cancer cells, any of which can trigger the body’s immune system defenses. In a report published in the issue of Nature Medicine online Oct. 31, researchers describe a new “epitope-mapping” laboratory test that within three weeks can pinpoint the unique binding site—or epitope—from any antigen where immune system T cells can most securely attach and attack invading germs or errant cells. Knowing exactly where the best anti-

stretches of proteins, called peptides, bind and are displayed on the surface of antigen-processing immune system cells—is a pre-requisite for designing effective and targeted drug therapies, researchers say. Identifying the best binding site, they say, should speed up cancer vaccine devel-opment, lead to new diagnostic tests that detect the first appearance of cancer cells, well before tumors develop, and sort out disorders that are difficult to diagnose, such as Lyme disease. “Our new, simplified system reproduces what happens in the cells of the immune system when antigens from a pathogen first enter the body and need to be broken down into peptides to become visible to T cells, one of the two immune defender cell types,” said immunologist Scheherazade Sadegh-Nasseri,

an associate professor of pathology, biophys-ics and biophysical chemistry at the Johns Hopkins University School of Medicine. “Once T cells recognize an antigen, they latch on, become activated and call for other immune system cells to enter the fight,” said Sadegh-Nasseri, the senior study investigator for the team of scientists who developed the new epitope-mapping process. Sadegh-Nasseri said that the team’s new lab test takes a fraction of the time involved in current methods, which rely on sequenc-ing, or identifying every single peptide in the antigen’s makeup, one after another. Such sequencing can take months, or even years, to identify possible T cell binding sites. “The added beauty of our system is that the entire process can be done in the lab, so we do not have to perform tests in people,” said Sadegh-Nasseri, who has a patent pend-ing for the test. The Johns Hopkins team, including co-lead investigators AeRyon Kim and Isamu Hartman, also immunologists, based their test on nearly 20 years of the team’s previ-ous research into how immune system cells selectively process antigens and the maze of possible protein combinations inside. That cumulative research led them to nar-row their search to five essential and well-described proteins involved in antigen pro-cessing by immune system cells. In its latest series of experiments, the team tested a mix of the selected immune system proteins to see if it could accurately detect two already known epitopes, those of the Texas strain of the influenza virus and type II collagen, both widely used experi-mental antigens. Then, they used the mix to find unknown epitopes for portions of the

Immune system’s bare essentials used to detect drug targetsinfluenza virus that causes avian flu and for the parasite involved in malaria. Chief among the epitope-mapping test’s chemical components was a protein mol-ecule called HLA-DR that is common to all the body’s immune system cells. This mol-ecule is one of the most common binding molecules used in the natural immune sys-tem’s peptide selection process. HLA stands for human leukocyte antigen, and HLA-DR is produced in a gene-dense region of the body’s immune system, the major histocom-patibility complex. Other key chemicals in the makeup were HLA-DM, another protein compound that disrupts the binding of HLA-DR molecules to an antigen if the fit is not perfect, and three of the most common enzymes, so-called cathepsins, involved in breaking up the antigen into its visible, identifiable pro-tein parts. In the first set of experiments, the team mixed chemical solutions of each antigen with the five key proteins and used mass spectrometry—an electron-beaming device that can measure the exact makeup of mol-ecules—to determine the best-fitting peptide based on precisely which segment of the antigen appeared as mass peaks. Peaks would indicate that HLA-DR had successfully bound to the antigen at a likely epitope. Next, researchers confirmed their mass spectrometry findings by injecting mice bred to produce human HLA-DR with each anti-gen to trigger a standard immune response and collecting samples of the resulting T cells. The T cells were then grown in the lab and exposed to various peptides, including the suspect epitopes, to identify and confirm that only one triggered the greatest chemi-

cal response from the cultured T cells. The scientists knew that if they could match a peak highlighted by mass spectrometry to the peptide that produced the greatest T cell reaction, they had found the most heavily favored epitope. When both tests were performed on any of the four disease antigens, researchers were able to narrow the suspect binding sites to one “immunodominant” epitope each for Texas strain of the flu, type II collagen, avian flu and malaria. Kim, a postdoctoral research fellow at Johns Hopkins, said that designing both experiments and completing the verification study took some seven years, noting that adding HLA-DM, which she calls a protein editor, was the pivotal factor in making the initial epitope-selection process work. Researchers said that their next steps are to broaden and refine their chemical mix-ture for selecting and identifying possible epitopes for other kinds of HLA because the current set of experiments analyzes only one of the most common HLA-type molecules in whites. Study support was provided with funding from the National Institute of Allergy and Infectious Diseases. Additional funding came from the Johns Hopkins Malaria Research Institute. In addition to Sadegh-Nasseri, Kim and Hartman, Johns Hopkins research-ers involved in this study were Robert Cot-ter, Kimberly Walters, Sarat Dalai, Tati-ana Boronina, Wendell Griffith and Robert Cole. Hartman is now at University of Texas Southwestern Medical Center. Other inves-tigators, based at the U.S. Walter Reed Army Institute of Research, were Robert Schwenk, David Lanar and Urszula Krzych.

Page 10: The Gazette

10 THE GAZETTE

This is a partial listing of jobscurrently available. A complete list

with descriptions can be found on the Web at jobs.jhu.edu.

Job OpportunitiesThe Johns Hopkins University does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, or other legally protected characteristic in any student program or activity administered by the university or with regard to admission or employment.

S c h o o l s o f P u b l i c H e a l t h a n d N u r s i n g

H o m e w o o d 43015 LAN Administrator II43041 Software Engineer43060 DE Instructor, Center for Talented Youth

for Talented Youth43115 Residential Life Administrator43152 Tutor43244 Building Operations Supervisor43245 Building Maintenance Technician43250 Program Manager, Center for Talented Youth43403 Admissions Officer42291 Project Manager LDP

42942 Multimedia Technician43341 Sr. Technical Support Analyst43395 Research Service Analyst

Office of Human Resources:

JOB# POSITION

43101 Accounting Aide

43251 Network Analyst43294 Research Service Analyst

43336 Programmer Analyst

43405 Accountant43406 Sr. OD Specialist43411 Accounting Manager43442 Instructional Facilitator

Coordinator

Office of Human Resources:2021 East Monument St., 410-955-3006JOB# POSITION

44290 LAN Administrator III

44939 Student Affairs Officer44555 Instructional Technologist

43425 Research Nurse43361 Research Scientist44554 Administrative Specialist

45106 Employment Assistant/Receptionist45024 Payroll and HR Services Coordinator42939 Research Data Coordinator

42669 Data Assistant

44242 Academic Program Administrator44661 Sr. Research Program Coordinator45002 Research Observer

American Journal of Epidemiology44005 Research Service Analyst

44065 Research Data Manager44112 Sr. Laboratory Coordinator

39063 Research Assistant44603 Budget Analyst

P O S T I N G S

S c h o o l o f M e d i c i n e

Office of Human Resources:

JOB# POSITION

30501 Nurse Midwife22150 Physician Assistant

B U L L E T I N B O A R D

NoticesMLK Jr. Community Service Award Nominations — Organizers of the upcom-ing Martin Luther King Jr. Commemoration Celebration are calling for nominations of faculty, staff, graduate students and retir-ees for the 2010 Martin Luther King Jr. Award for Community Service. Recipients who demonstrate the spirit of volunteerism, citizenship and activism that characterized King’s life will be recognized at the annual commemoration event, to be held in Janu-ary. To submit a nomination, go to hrnt.jhu .edu/mlk. The deadline is Nov. 15. For more information, university affiliates should con-tact Amanda Sciukas at [email protected]

health system should contact Christina Pickle

Season of Giving — During the holiday season, the Office of Work, Life and Engage-ment is inviting the Johns Hopkins commu-nity to help the less fortunate by participat-ing in its Season of Giving programs. In November, a $20 donation to the JHU Vernon Rice Memorial Butterball Turkey Program will provide a food basket, contain-ing a fresh turkey and vegetables from local and free-range farms, to a family in need for the Thanksgiving holiday. During December, faculty, staff, students and retirees can participate in the Adopt-a-Family/Adopt-a-Senior program, conducted in partnership with local nonprofit social services agencies. Participants can provide gifts, clothing and/or grocery store gift cards to individuals who may not otherwise receive or be able to afford gifts during the holiday. To participate or to learn more about the programs, go to hopkinsworklife.org/community/index.cfm or contact Brandi Monroe-Payton at [email protected] or

Continued from page 1

Malaysia

kins were Edward D. Miller, dean of the School of Medicine and CEO of Johns Hop-kins Medicine; Mohan Chellappa, president for global ventures at Johns Hopkins Medi-cine International; David Nichols, vice dean for education in the School of Medicine; Steve Thompson, senior vice president of Johns Hopkins Medicine; and Charles Wie-ner, professor of medicine and vice chair of education in the School of Medicine, who has been named the founding and interim dean and CEO of the medical school and hospital. The school, to be called Perdana Univer-sity Graduate School of Medicine, will open in fall 2011. “For more than a century, Johns Hopkins has been recognized as a national and global leader in patient care, research and educa-tion,” Miller said. “We are honored to have an opportunity to share our innovations and best practices with the people of Malaysia. We firmly believe that this project will help us to continue our historic and vital mission of helping to raise the standards of health care around the world.” Under the agreement, Johns Hopkins will assist with the development of every major aspect of the new medical enterprise, includ-ing medical education programs, campus design and facilities planning, and clinical affairs. Johns Hopkins also will guide aca-demic development in alignment with the breakthroughs of its new Genes to Society curriculum and will consult on other impor-tant components, including the teaching environment and infrastructure, pedagogy, administration and student affairs. Johns Hopkins also will provide guidance on the design and development of Perdana University Hospital, a 600-bed teaching facility that will include a full complement of ambulatory care facilities, diagnostic capabilities and ancillary support services. And, in a third major component of the agreement, Johns Hopkins will advise Malaysian colleagues on the development and integration of research programs across the entire medical enterprise. Operationally, all education, patient care and research functions and programs will be managed in accordance with the Johns Hopkins Medicine organizational and oper-ational model. “It is a great privilege to be able to assist Malaysia with the establishment of its first private graduate medical school and teaching hospital,” Nichols said. “Not only will this

collaboration have a transformational impact on the quality of medical education, research and health care delivery for Malaysia and the region, but it also will bring a wide range of benefits to the university, departments, fac-ulty and staff here in Baltimore.” Johns Hopkins will provide a leadership team for the new school that includes vice deans as well as a founding dean and CEO; advise and consult with its Malaysian part-ners on faculty and student recruitment; recruit and supply founding core faculty and staff, who will administer the Genes to Soci-ety curriculum and advance the new school’s research mission; provide training in the Genes to Society curriculum and educa-

Hopkins faculty; and advise and consult in campus design, research program develop-ment and hospital operations. Johns Hopkins faculty will have oppor-tunities to take temporary or potentially permanent assignments of six months to two years at Perdana University Graduate School of Medicine or Perdana University Hospital; participate as curriculum trainers for Malaysian and other international fac-ulty, or in specific research collaborations, during their stays in Baltimore; or visit Kuala Lumpur as guest faculty for one to two weeks. JHM staff will also be eligible for some temporary or permanent positions. “This is a remarkable opportunity to trans-form the medical educational system and introduce a new thematic medical paradigm to Southeast Asia,” said Wiener, who will take up residence in Malaysia in January. “The people there are enthusiastic about medical education reform and establishing an aca-demic medical center with Hopkins values. “I hope that the Johns Hopkins community will share this excitement and participate in the groundbreaking effort,” he said. “We are looking for teachers and role models who are looking to live in this exciting environment. Johns Hopkins is deeply invested in the suc-cess of this collaboration. I welcome people who want to be part of it.” The curriculum, Wiener said, will be in English, and applicants will be required to complete the MCAT in English. The school is projected to open with up to 100 “highly qualified” students, Wie-ner said. David Trabilsy, former director of admissions at the Johns Hopkins School of Medicine, will be interim director for medi-cal student admissions. In preparation for

staff from Johns Hopkins are expected to be in place in Malaysia in July. Academic Medical Centre’s primary focus is to develop Perdana University, a public-private partnership. Chase Perdana holds

Medical Centre, while Turiya Berhad owns the remaining 20 percent. A premier con-struction company in Malaysia and the Middle East, Chase Perdana was the main contractor to design and build the Uni-versity Malaysia Sabah, one of the premier universities in Malaysia. G

Read The Gazette online gazette.jhu.edu

Page 11: The Gazette

GAZETTE 11

ClassifiedsAPARTMENTS/HOUSES FOR RENT

Baltimore City, updated 1BR condo in secure gated community, assigned prkng, swimming, tennis, nr hospital and univer-sity; option to own ($135,000). $1,200/mo

Belvedere Square, 2BR, 1.5BA upstairs apt unit, lg living and dining area, kitchen, hdwd flrs, powder rm, fp, balcony, quiet residential neighborhood 10 mins to JHU Homewood, 15 mins to JHMI. 410-435-

Bolton Hill, 1BR studio apt w/luxury BA,

everything. [email protected].

Butchers Hill, fully furn’d 1BR + office, dw, W/D, all appls, hdwd flrs, satellite TV, DVD player, WiFi access, sec sys, cute cottage-style RH south of JHMI. $1,100/mo + utils. [email protected].

Canton, 2BR, 2.5BA rehabbed TH, great location close to JHH/JHMI. Courtney, [email protected].

Canton, 2-3BR, 2.5BA harborfront TH, fully furn’d, entertainment system, granite counters, marble flrs, stainless steel appls, 2-car garage. 443-955-2040.

Charles Village apts: studio ($625/mo) and

incl’d for both. [email protected].

Charles Village, spacious, bright 3BR apt,

443-253-2113 or [email protected].

Clipper Mill, lovely 3BR, 3.5BA, 2-car garage, bonus rm, deck, community swim-ming pool, Woodberry lt rail station yds away, nr walking trail and Druid Hill Park, avail short-term or yearly lease, nr Univer-

Columbia/Howard, newly renov’d 3-4BR TH, 3.5BAs, family rm, priv BA, W/D, AC, carpool to JHU, nr community college and Columbia town center. $450/$550/mo

[email protected].

Ellicott City, 4BR, 2.5BA single-family house w/fin’d bsmt, 2-car garage, lg backyd, excel schools and location. $2,600/mo +

.com.

Evergreen/Roland Park, sunny, furn’d 3BR house, available January-June 2011, 20-min walk to Homewood campus and shuttle.

Hampden, 3BR, 2BA TH, dw, W/D, fenced yd, nr light rail. $1,100/mo + utils. 410-

Mt Vernon, 2BR split-level condo, hdwd flrs, walk-in closets, skylight, fp, deck, prkng.

gmail.com.

Mt Washington, 2BR, 2BA apt in Ivymount community, pet-friendly, incredible view of the woods, avail Dec 15. $1,395/mo incl

yahoo.fr.

Rosedale, 3BR single-family house, nice kitchen, dining rm, living rm, W/D, lg, priv backyd, garage, 5-min drive to JHMI, ideal

M A R K E T P L A C E

for 2 postdocs to share. $900/mo + utils.

Union Square, 1BR boutique apt in Victo-rian TH, furn’d, flexible terms, in historic

gmail.com or http://therichardsonhouse .vflyer.com/home/flyer/home/3200019.

Wyman Court Apts (Beech Ave), new, spacious efficiency w/balcony, sunlight, 3 closets, 5-min walk to Hopkins. $625/mo. [email protected].

Cozy 3BR, 2.5BA house nr Homewood/Tow-son University/Belvedere Square, charming house perfect for family/friends to share, hdwd flrs throughout, fin’d bsmt, front and

gmail.com.

3BR, 1BA TH w/bsmt, fenced backyd w/patio, nr JHU campus, perfect for grad stu-dent or faculty. $1,300/mo (1st month free). 410-925-6646.

TH nr JHMI, 2BRs each w/priv BA, 1st flr, living rm, dining rm, kitchen, W/D, AC,

Lg, renov’d 1BR apt w/new kitchen, BA,

HOUSES FOR SALE

Gardenville, 3BR, 1.5BA RH in quiet neigh-borhood, new kitchen and BA, CAC, hdwd flrs, club bsmt, fenced, maintenance-free yd w/carport, 15 mins to JHH. $139,500. 443-610-0236 or [email protected].

Greektown house, why rent when you can

Hampden, updated 2BR, 2BA TH, hdwd flrs, CAC, lg closets, beautiful deck, prkng, easy walk to Homewood campus. $209,000.

Mt Vernon, adorable efficiency co-op on Hopkins shuttle route, sophisticated, secure

Cozy 3BR, 2BA condo, separate garage, walk-ing distance to the university, great price,

verizon.net.

Last chance to own a fabulous house, while mortgage rates are still low, ideal

www.3402mountpleasantavenue.canbyours .com.

full BAs, new kitchen, fin’d bsmt, great pub-

ROOMMATES WANTED

Share 3BR, 2.5BA RH in Wyman Park/Rem-ington area, fin’d bsmt, W/D, dw, cable, Inter-net, deck, prkng, 2 blks to Homewood cam-pus. $450/mo + share of utils. nancyshipley@ hotmail.com.

Mature grad student/prof’l wanted for 2 lg rms in historic RH, share w/prof’l couple, share all common space, free WiFi, W/D, suite is unfurn’d w/bed avail, pref nonsmok-

F wanted for rm w/priv BA in lg 2BR, 2BA

view, swimming pool, gym, sauna, doorman, 24-hr security, underground prkng, walk to

1BR avail in 3BR house in Cedonia, owned by young F prof’l, modern kitchen, lg deck, landscaped yd, free prkng, nr JHH/Home-wood/Morgan State, nr public transporta-tion, pets welcome. $550/mo + utils. 410-493-2435 or [email protected].

Share all new refurbished TH w/other medi-cal students, 924 N Broadway, 4BRs, 2 full BAs, CAC, W/D, dw, w/w crpt, 1-min walk to JHMI. [email protected].

CARS FOR SALE

‘04 VW Golf, silver w/black interior, new tires and brakes, 40K mi, in good cond.

‘96 VW Jetta, Trek edition, black, manual transmission, 1 owner, in great cond, free

ITEMS FOR SALE

Authentic Michael Kors bag, stud detail, red leather, brand new, $100; new replica Gucci handbag, black leather, $200; authentic

Sand beach chairs (2), three-step ladders (2), dresser w/shelves, reciprocating saw,

[email protected].

2-pc sectionals (2), one cream-colored, the other dk beige. $450/ea. kiera_wise@yahoo .com.

Conn alto saxophone, best offer; exercise rowing machine, $50; both in excel cond.

body work, helmet incl’d, 2K mi. 410-320-

Beautiful Chickering baby grand piano, in excel cond, all ivory keys in great

[email protected].

Knabe upright piano, immaculate condi-

Beautiful living rm set: sofa, loveseat, end tables (2), lamps (2), coffee table w/glass

Formal oak dining rm table and 6 fabric-

in excel cond. [email protected].

SERVICES/ITEMS OFFERED OR WANTED

Free if you can haul it: Two lg blue circular sofas from Storehouse, use together for con-

Wanted: advanced Peabody piano student to teach popular piano music to my son in

.edu.

Classified listings are a free ser-vice for current, full-time Hop-kins faculty, staff and students only. Ads should adhere to these general guidelines:

new request must be submitted for each issue.

including phone, fax and e-mail.

business phone numbers or e-mail addresses.

the editor’s discretion.

one week prior to the edition in which the ad is to be run.

only by a Hopkins-affiliated seller not by Realtors or Agents.

(Boxed ads in this section are paid advertisements.)Classified ads may be faxed to 443-287-9920; e-mailed in the body of a message (no attach-ments) to [email protected]; or mailed to Gazette Classifieds, Suite 540, 901 S. Bond St., Bal-

a boxed display ad, contact the Gazelle Group at 410-343-3362.

PLACING ADS

Clarinet and piano lessons available, cur-

yrs’ experience. $20/half-hour, $40/hour.

.com.

Responsible, fun and creative babysitter/nanny and recent Peabody grad available on short notice, if interested, could also teach beginner piano or beginner Spanish/French.

Roland, nr Homewood campus), seeks after-school tutors for Tues, Wed or Thurs, 3:15-

[email protected].

Mature, experienced nanny available, warm, energetic, upbeat and very reliable, outstanding references from JHU faculty.

Need help with your JHU retirement plan investments portfolio? Free, confidential consultation. 410-435-5939 or treilly1@aol .com.

Absolutely flawless detailing; visit website for package info. Jason, 410-630-3311.

Friday Night Swing Dance Club, open to public, no partners needed, great bands. 410-663-0010 or www.fridaynightswing.com.

Tutor avail for all subjects/levels; remedial and gifted; also help w/college counseling, speech and essay writing, editing, proofread-ing, database design and programming. 410-

Licensed landscaper avail for lawn mainte-nance, yd cleanup, other landscaping servic-es, trash hauling, fall/winter leaf and snow

6090 or [email protected].

Need a photographer or videographer for weddings, other events? Edward S Davis

[email protected].

Experienced gardener wanted to help w/fall cleanup and planting. $15/hr. Jim, 410-366-

Bodywork massage studios, professional massage services, gift certificates avail. 443-

.com.

Affordable and professional landscaper/cer-tified horticulturist available to maintain existing gardens, also designing, planting or masonry; free consultations. David, 410-

Trustworthy dog walker avail day and eve-ning, overnight sitting w/complimentary housesitting services, impeccable referenc-

.com.

Soup for the Soul fund raiser, Nov 20,

mentoring families living in poverty. Tickets

Professional landscaping at its finest, high-quality landscaping at an afford-able price. Terry Butler, 410-652-3446 or [email protected].

Graphic designer w/20 yrs’ experience, 10 yrs in Web design, can assist w/reports, pre-

or [email protected].

Federal Hill Sublet - Female non-smoker for 1 BD (furn.) w/closet + new priv. BA in 3 BD w/ 2

female students. W/D new kitch/LR, Pking, rooftop balcony, Cable, CAC, close to universities, dining, ball parks, transportation, Avail - 1/1/11 to 9/1/11

$900mo./inclusive + 1 mo. Sec. dep. 631-428-6310,

WYMAN COURTBeech Ave. adj. to JHU!Studio from $570

1 BD Apt. from $675 2 BD from $785

HICKORY HEIGHTSHickory Ave. in Hampden,

lovely Hilltop setting! 2 BD units from $750,

or, with Balcony - $785!

Shown by appointment - 410-764-7776www.BrooksManagementCompany.com

Page 12: The Gazette

12 THE GAZETTE

Calendar C O L L O Q U I A

Tues., Nov. 9, 4:15 p.m. “The Chemistry and Biology of Subglu-tinols A and B,” a Chemistry col-loquium with Jiyong Hong, Duke University. 233 Remsen. HW

Wed., Nov. 10, 3:30 p.m. “Dust Formation and Evolution in Core-Collapse Supernovae: Clues to Understanding the Dust Content of Early Galaxies,” an STSci col-loquium with Geoff Clayton, Lou-isiana State University. Bahcall Auditorium, Muller Bldg. HW

Wed., Nov. 10, 4 p.m. “The Race of Nimble Fingers: Chang-ing Patterns of Child Labor in South Africa’s Wine Industry,” an Anthropology colloquium with Susan Levine, University of Cape Town. 404 Macaulay. HW

Wed., Nov. 10, 4 p.m. “Spa-tial Representation in the Mind/Brain: Do We Need an Internal Spatial Map?” a Psychological and Brain Sciences colloquium with Zenon Pylyshyn, Rutgers Univer-sity. 233 Ames. HW

Thurs., Nov. 11, 3 p.m. “Twenty-five Years of Lattice Gauge Theory: Consequences of the QCD Lagrangian,” a Phys-ics and Astronomy colloquium with Andreas Kronfeld, Fermilab. Schafler Auditorium, Bloomberg Center. HW

Thurs., Nov. 11, 3 p.m. “ ‘Be Secret in Any Matter Apper-taining to Your Office’: Mid-wives, Gossip and the Secrets of Women,” a History of Science and Technology colloquium with Sam Thomas, University of Ala-bama, Huntsville. Seminar Room, 3rd floor, Welch Library. EB

Thurs., Nov. 11, 3:45 p.m. “Recognizing Questions,” a Cog-nitive Science colloquium with Christine Gunlogson, University of Rochester. 134A Krieger. HW

Thurs., Nov. 11, 4 p.m. “Shake-spearean Autonomy,” an ELH col-loquium with Stephen Greenblatt, Harvard University. Sponsored by English. 130D Gilman. HW

Fri., Nov. 12, 2 p.m. “Our Eco-nomic Insecurity and Its Relation-ship to the Overall Security of the Nation,” an Applied Phys-ics Laboratory colloquium with Michael Greenberger, University of Maryland. Kossiakoff Audito-rium. APL

Fri., Nov. 12, 4 p.m. “On the Postcolony: Ten Years On,” an Anthropology colloquium with Achille Mbembe, Wits Institute for Social and Economic Research. 404 Macaulay. HW

C O N F E R E N C E S

Mon., Nov. 8, 5 to 6:30 p.m. “Cyber Security,” a SAIS Review of International Affairs conference with Howard Schmidt, cyber security coordinator at the White House. For information, e-mail

Sun., Nov. 14, 5:30 p.m. The Shriver Hall Concert Series pres-ents cellist Gautier Capucon and pianist Gabriela Montero. (See

-sion, $19 for non-JHU students; free for JHU students. Shriver Hall Auditorium. HW

R E A D I N G S / B O O K T A L K S

Mon., Nov. 8, 5 p.m. Win-ter Olympic speed skater Apolo Ohno will sign copies of his life story, Zero Regrets: Be Greater Than Yesterday. Barnes & Noble Johns Hopkins. HW

Mon., Nov. 8, 6 p.m. Reading by poet Tan Lin, New Jersey City University. Sponsored by English. 50 Gilman. HW

Thurs., Nov. 11, noon. Nature author John Vaillant will dis-cuss and sign copies of his latest book, The Tiger: True Story of Ven-geance and Survival. Sponsored by the Center for a Livable Future. W1030 SPH. EB

S E M I N A R S

Mon., Nov. 8, 12:15 p.m. “The Woman Question in Medicine and Bioethics,” a Berman Institute of Bioethics seminar with Hilde Lin-demann, Michigan State Univer-sity. Co-sponsored by Gynecology and Obstetrics and by Population, Family and Reproductive Health.

SPH. EB

Mon., Nov. 8, 2:30 p.m. “Human Common Disease and Mouse Phe-notype Gene Sets in the Analysis of Microarray and Human GWAS Data,” a Center for Computation-al Genomics seminar with Kevin Becker, NIH Biomedical Research

EB

Mon., Nov. 8, 4 p.m. “Health Reform: Policy and Politics,” a Social Policy seminar with Mark Duggan, University of Maryland. Sponsored by the Institute for Policy Studies. 526 Wyman Park Bldg. HW

Mon., Nov. 8, 4 p.m. “A Portrait of a Soviet Woman as Citizen Sol-dier: Theoretical and Interpretive Challenges,” a History seminar with Anna Krylova, Duke Univer-sity. 305 Gilman. HW

Mon., Nov. 8, 4 p.m. “Pointwise Decay on Nonstationary Space-times,” an Analysis/PDE seminar with Mihai Tohaneanu, Purdue University. Sponsored by Math-ematics. 304 Krieger. HW

Mon., Nov. 8, 4 p.m. “Genomic Analysis of the Saccharophagus degradans Cellulolytic System,” JHU Bioenergy Group seminar with Steve Hutcheson, University of Maryland. 205 Krieger. HW

Mon., Nov. 8, 4:30 p.m. “Trans-chromatic Generalized Character Maps,” a Topology seminar with Nathaniel Stapleton, University of Illinois, Urbana-Champaign. Sponsored by Mathematics. 300 Krieger. HW

Tues., Nov. 9, 10:30 a.m. “The Pelvis in Hominid Evolution: Body Form, Hip Function and Locomotor Adaptation,” a Center for Functional Anatomy and Evo-lution seminar with Carol Ward,

N O V . 8 – 1 5

(Events are free and open to the public except where indicated.)

APL Applied Physics LaboratoryBRB Broadway Research BuildingCRB Cancer Research BuildingEB East BaltimoreHW HomewoodKSAS Krieger School of Arts and SciencesPCTB Preclinical Teaching BuildingSAIS School of Advanced International StudiesSoM School of MedicineSoN School of NursingSPH School of Public HealthWBSB Wood Basic Science BuildingWSE Whiting School of Engineering

CalendarKey

[email protected] or call 202-531-

jhu.edu. Kenney Auditorium, Nitze Bldg. SAIS

D I S C U S S I O N / T A L K S

Tues., Nov. 9, 6 p.m. “Ideas and Economic Crises in Britain From Attlee to Blair,” a SAIS Center for Transatlantic Relations Pro-gram panel discussion on Matthias Matthijs’ book of the same name. Panelists are Matthijs, Ameri-can University and SAIS; Peter Matheson, British Embassy; Mark Blyth, Brown University; Daniel Hamilton, director, CTR; and Pravin Krishna, moderator, SAIS. To RSVP, go to transatlantic.sais-jhu.edu/events/2010/matthijs.htm. Co-sponsored by the International Economics Program and the Ber-nard L. Schwartz Forum on Con-structive Capitalism. Rome Audi-torium. SAIS

Wed., Nov. 10, 2:30 p.m. “Bos-nia and Herzegovina After the Elections: Prospects for Bringing Bosnia Back on the EU Reform Path,” a SAIS Center for Transat-lantic Relations panel discussion with Daniel Serwer, Vedran Dzi-hic and Michael Haltzel, SAIS; Kemal Kurspahic, managing edi-tor, The Connection Newspapers, and founder, Media in Democ-racy Institute. To RSVP, e-mail [email protected] or call

Bldg. SAIS

Thurs., Nov. 11, 12:30 p.m. “Combating Slavery in Ghana,” a SAIS African Studies Program discussion with James Kofi Annan, founder and executive director, Challenging Heights. A Year of Demography event. Co-sponsored by the SAIS International Law and Organizations Program. For information, e-mail itolber1@jhu

Bernsein-Offit Bldg. SAIS

Thurs., Nov. 11, 6:30 p.m. “Picturing the Shahnameh: Word and Image in Ferdowsi’s Book of Kings,” with Massumeh Farhad, chief curator and curator of Islamic art, Arthur M. Sackler and Freer Gallery of Art. Part of the SAIS

Cultural Conversations series. To RSVP, e-mail [email protected] or call 202-663-5635. Kenney Auditorium, Nitze Bldg. SAIS

Mon., Nov. 15, noon. “Beyond Separatism: Interpreting Cana-dian Federalism in Quebec,” a SAIS Canadian Studies Program discussion with Guy Laforest, Universite Laval, and David Rovinsky, U.S. State Depart-

SAIS

G R A N D R O U N D S

Mon., Nov. 8, 8:30 a.m. “Recent Advances in the Diagnosis and Management of Human Allergic Disease,” Pathology grand rounds with Robert Hamilton, SoM. Hurd Hall. EB

Mon., Nov. 15, 8:30 a.m. “Rats, Lice and History: Suc-cesses and Misadventures of a Clinical Microbiologist on the Fringe,” Pathology grand rounds with Steve Dumler, SoM. Hurd Hall. EB

L E C T U R E S

Wed., Nov. 10, 4 p.m. The 2010 Lawrence Grossman Lec-ture—“Human DNA Mismatch Repair: What We’ve Learned About How It Works,” with Paul Modrich, Duke University School of Medicine. Sponsored by Biochemistry and Molecular Biology. W1214 SPH. EB

Wed., Nov. 10, 8 p.m.annual Sidney W. Mintz Lecture in Anthropology—“Imaginary Moneys: Transactions, Markets and the State of Haiti” by Federi-co Neiburg, Federal University of Rio de Janeiro, Brazil. Sponsored by Anthropology. Mason Hall Auditorium. HW

Thurs., Nov. 11, 4:30 p.m. “The Invisible Demos of Per-gamon: A Subversive Reading of Attalid Kingship,” a Classics lecture by Ruth Bielfeldt, Har-

HW

Thurs., Nov. 11, 4:30 p.m.

Series—“ ‘We Must Do Better’—Three Decades of Research, Col-laboration and Mentorship to Improve the Safety and Health of Abused Women” by Jacquelyn Campbell, SoN. 110 Hodson. HW

Thurs., Nov. 11, 5:15 p.m. “A Geneaological Approach to the Narconovel,” a German and Romance Languages and Literatures lecture by Hermann Herlinghaus, University of Pitts-

HW

M U S I C

Sat., Nov. 13, 7:30 p.m. The Peabody Camerata performs music by Schoenberg, with guest artist mezzo-soprano Sonya Knus-sen. Griswold Hall. Peabody

Continued on page 9

Adman and TV personality Donny Deutsch is the next speaker in the Milton S. Eisenhower Sympo-sium. See Special Events.

University of Missouri. Room EB

Tues., Nov. 9, noon. “Mitochon-dria and Neurodegeneration,” a Biological Chemistry seminar with Hugo Bellen, Baylor College of Medicine. 612 Physiology. EB

Tues., Nov. 9, noon. “Moni-toring Secondhand Smoke: A Mechanism for Supporting Policy Development and Implementa-tion,” a FAMRI Center of Excel-lence at Johns Hopkins seminar with Stephen Tamplin, Institute for Global Tobacco Control. W1030 SPH. EB

Tues., Nov. 9, 12:10 p.m. “Role of Employee Assistance Programs in Addressing Intimate Part-ner Violence,” an Occupational Injury Prevention seminar with Keshia Pollack, SPH. Sponsored by the Center for Injury Research and Policy, the Department of Health Policy and Management, and the Education and Research Center for Occupational Safety

EB

Tues., Nov. 9, 3 p.m. “Sources, Storage and Flux of Sediment in the Chesapeake Watershed,” a Geography and Environmental Engineering seminar with Allen Gellis, U.S. Geological Survey, MD-DE-DC Water Science Cen-ter. 234 Ames. HW

Tues., Nov. 9, 4 p.m. “Genome-wide Approaches to Manipulate Flies,” a Biological Chemistry seminar with Hugo Bellen, Baylor College of Medicine. 490 Rangos. EB

Tues., Nov. 9, 4:30 p.m. “Lan-guage-Universal Speech Model-ing: What, Why, When and How,” a Center for Language and Speech Processing seminar with Chin-Hui Lee, Georgia Institute of Technol-

HW

Wed., Nov. 10, noon. “Learning About Potassium Channels by Knocking Out Their Beta Sub-units,” a Physiology seminar with Geoffrey Abbott, Weill Cornell Medical College. 203 Physiology. EB

Wed., Nov. 10, 12:15 p.m. Wednesday Noon Seminar—

Results and Challenges from the NSA and NSA-R” with Benja-min Saunders, Medical Univer-sity of South Carolina. Sponsored by Mental Health. B14B Hamp-ton House. EB

Wed., Nov. 10, 1:30 p.m. “Struc-tural and Functional Insights to Post-Translational Modifica-tion by SUMO, a Ubiquitin-like