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the Future is here & now Slide 2 Slide 3 The Therapeutic development has two hearts and one soul Slide 4 for critical care staff The simplicity of using one single system for the widest variety of treatments The serenity of automated and simple management of complex treatments 24h/24h. The reduction and optimization of the number and time of the operation Slide 5 for Clinicians A big and important therapeutic choice An advanced and targeted personalization capability Complete control of the therapeutic process Slide 6 Critical Care Strategy SEPSIS MOF Multi-organ failure ALI SIRS Liver Failure AKI HYPERCHOLESTEROLEMIA DEGENERATIVE MACULOPATHIES DIABETIC FOOT RHEUMATOID ARTHRITIS MYASTHENIA GRAVIS GUILLAIN-BARR SYNDROME GLOMERULONEPHRITIS ARDS many diseases in ONE equipment RRT: SCUF CVVH IHF/HVHF CVVHD IHD/SLED CVVHDF IHDF CPFA CASCADE PEX ABYLCAP ABYLCAP HD Specific and effective therapies Slide 7 RRT: SCUF CVVH IHF/HVHF CVVHD IHD/SLED CVVHDF IHDF CPFA CASCADE PEX ABYLCAP ABYLCAP HD The Amplya Therapies Specific Sorbents COMPLETENESS Slide 8 Hemofilter Plasmafilter Citrate CaCl 10% Post dilution Uf Mediasorb CPFA with Citrate COMPLETENESS Slide 9 COMPACT study results In-hospital Intensive Care Mortality controls Tertiles CPFA dose (L/Kg) Mortality rate in-hospital and in Intensive Care units for CPFA dose in 3 days of treatment The study explain that if we perform the CPFA with right dose of plasma, the mortality change from. 55,2% Vs 25,8% Relative Risk= 46% Personalized CPFA management with controlled servo-assisted flow AUTOMATION Slide 10 RRT: SCUF CVVH IHF/HVHF CVVHD IHD/SLED CVVHDF IHDF CPFA CASCADE PEX ABYLCAP ABYLCAP HD The Amplya Therapies COMPLETENESS Slide 11 CASCADE FILTRATION PLASMAFILTRO PLASMA For the removal of : CIC (Circulating Immune Complexes) IgM IgG Triglycerides Lipoproteins In case of: Hypercholesterolemia Degenerative maculopathies Diabetic foot Rheumatoid arthritis Myasthenia Gravis Guillain-Barr Syndrome. Slide 12 CASCADE Rinsing LIQUIDO DI LAVAGGIO PLASMAFILTRO Slide 13 RRT: SCUF CVVH IHF/HVHF CVVHD IHD/SLED CVVHDF IHDF CPFA CASCADE PEX ABYLCAP ABYLCAP HD The Amplya Therapies COMPLETENESS Slide 14 Uf O2 CO2 HD Dialysate flow Slide 15 Slide 16 Multiorgan Dysfunction: many medical devices? Slide 17 Slide 18