The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY:...
-
Upload
colin-edmund-grant -
Category
Documents
-
view
215 -
download
1
Transcript of The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY:...
![Page 1: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/1.jpg)
The Food and Drink Innovation Network
Foods That Manage Weight
28th June 2007
CASE STUDY: SLENDERIZE
Dr Trevor Jarman, Natures Remedies Ltd
![Page 2: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/2.jpg)
Weight loss aid: wish-list
Proven, healthy rate of weight loss
Natural ingredients
Known mechanism– Preferably satietyPreferably satiety
No radical change in diet
Lasting effect; no yoyo
![Page 3: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/3.jpg)
Solution:
Developed by international team of medics
Natures Remedies Ltd formed to launch Zotrim in UK
Supplied in tablet form
![Page 4: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/4.jpg)
Ingredients
Extracts of three traditional South American herbs with a history of use in Europe:
Yerba Maté: Leaves are used as refreshing tea in Argentina and Paraguay.
Guarana: Stimulant; extract of seeds widely drunk in Brazil
Damiana: Leaves used as tonic and aphrodisiac.
‘Magic shrapnel’ Synergistic impact of complex mixtures
![Page 5: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/5.jpg)
Weight loss evidence Placebo-Controlled clinical trial
45-day placebo-controlled study47 overweight subjects with BMI 25–30
Undertaken by Dr Torben S AndersenJ Human Nutrition Dietetics, 14, 243-250, 2001
Weight loss; kg0 1 2 3 4 5
Placebo
![Page 6: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/6.jpg)
Weight maintenanceExtended trial
Following the trial subjects instructed to take Following the trial subjects instructed to take Zotrim again if gained > 2 lbsZotrim again if gained > 2 lbs
22 Completed 1 year
Average weight at start 73 kg Average weight at finish 72.5 kg
Undertaken by Dr Torben S AndersenJ Human Nutrition Dietetics, 14, 243-250, 2001
![Page 7: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/7.jpg)
MechanismSlowed stomach emptying
12
34
56
7
placebo
PGD
0
10
20
30
40
50
60
70
80
Time: min
Gastric emptying time (min) following herbal (green bars) and placebo (blue bars) capsules
in 7 subjects
Undertaken by Dr Jan Fogh (J Human Nutrition Dietetics, 14, 243-250, 2001)
![Page 8: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/8.jpg)
Decreased time to fullness
1
2
3
PGD
placebo
0
5
10
15
20
25
30
Time:min
meals:1-breakfast,
2-lunch, 3-dinner
Time to perception of gastric fullness aftermeals in ten subjects following Zotrim (green bars) and placebo capsules (blue bars)
PGD
placebo
Undertaken by Dr Torben S Andersen, Third Nutrition and Health Conference, London, 2002
![Page 9: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/9.jpg)
Nurses study (2006)
Study with 73 overweight nurses
Evidence of changed eating habits: Increased feeling of fullness Decreased hunger ratings Less tendency to snack Better portion control
Average weight loss 2.3 kg in 6 weeks22% with clinically significant weight-loss
![Page 10: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/10.jpg)
Nurses study (2006)
90
91
92
93
94
95
96
97
98
Baseline Week 10
Waist circumference (cm)
Ruxton et al, British Dietetic Assoc, 2006
80
80.5
81
81.5
82
82.5
83
83.5
84
84.5
Baseline Week 10
Weight (kg)
![Page 11: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/11.jpg)
Control over eating improved
0
20
40
60
80
100
120
Baseline Wk4 Wk6 Wk10
%
Neutral %
Disagree %
Agree %
“I often feel hungry and end up snacking too much between meals”
McNemar’s test, P<0.001
![Page 12: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/12.jpg)
Satiety significantly increased
0
1
2
3
4
5
6
7
8
9
10
Baseline Week 1 Week 4 Week 6 Week 10
Time Point
Me
an
fu
llne
ss
ra
tin
gs
Morning
Afternoon
Evening
Slight decrease when Zotrim withdrawn at Wk 10
![Page 13: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/13.jpg)
Weight loss compared with approved drugsActive Diet Period Loss A Loss P Rate A Rate A-P
(days) kg kg kg/4 wks
Zotrim 1 x 45 5.1 0.3 3.2 3.0Zotrim 2 x 28 1.8 - 1.8 -
Reductil x 56 2.6 0.4 1.3 1.1(Sibutramine)Reductil 56 7.4 3.3 3.7 2.0 (Sibutramine)Xenical 84 4.8 3.0 1.6 0.6(Orlistat)Acomplia 365 6.5 1.8 0.5 0.4 (Rimonabant)
A = Active, P= PlaceboRef: NICE Technology Appraisal Guidance No 22 & 31 (www.nice.org.uk)
![Page 14: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/14.jpg)
Weight loss compared with diet programmes
Weight-loss Waist-loss kg/week cm/week
Zotrim 1 0.8 -
Zotrim 2 0.45 1.07
Zotrim 3 0.38 0.57
Slim-fast 0.46 0.6 Rosemary Conley 0.5 0.56
Weight Watchers 0.59 0.69
Atkins 0.65 0.84
Ref; Ruxton et al, British Food Journal (2007)Ref:Truby et al, BMJ (2006)
![Page 15: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/15.jpg)
Infuzions Ltd; a group of enthusiastic and entrepreneurial beverage sales & marketing people
Jacob Bruun-Jensen, Co-Founder & Managing DirectorPreviously Director of Strategy at PepsiCo and Sales & Marketing Manager at Kraft Foods
Richard Abbott, Co-Founder & Commercial DirectorPreviously Director of Sales at Inbev UK
Spurred on by the immense success of new health drinks in the USA, a small group of people in close collaboration with food scientists and leading
nutraceutical manufacturers created and are now launching zipp®
![Page 16: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/16.jpg)
zipp®:
Award winning design, beautifully printed, satinised sleeved glass bottle * Primary target is women though products are also appealing to men
Look Good, Feel Even Better!Look Good, Feel Even Better!
Slenderize – Healthy weight loss, made deliciously simple with the UK’s leading
natural weight loss aid
Slenderize – Healthy weight loss, made deliciously simple with the UK’s leading
natural weight loss aid
Vitalize – More than just refreshing great taste with 75% RDA of essential vitamins &
minerals
Vitalize – More than just refreshing great taste with 75% RDA of essential vitamins &
minerals
![Page 17: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/17.jpg)
zipp®; seen as something very new and different
”
Women
Note: “Question: To what extend is this product new and different?”Source: Grenfield Research, April 2005 (n=874 with 300 respondents per concept)
42.8% 43.4%
33.6%
12.4%17.5%
6.6%
Concept 1 Concept 2 Benchmark
“Slenderize” “Vitalize” “Innocent Juicy”
Very
New
&
D
iffere
nt
Consumers really liked the interesting flavours, health promises and design
Extr
em
el
y
![Page 18: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/18.jpg)
Slenderize developmentZotrim choice based on
evidence of action synergistic profile enabled claims ability to formulate
100% soluble Zotrim formulation
Stability studies of Zotrim components in Slenderize
![Page 19: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/19.jpg)
zipp® Slenderize
Zotrim® is a world-wide patented herbal formulation from three South American herbs
We have the exclusive rights for Zotrim® in soft drinks in UK
Zotrim® is one of the leading U.K. natural weight loss aid – named the key driver of the market by Mintel1)
Zotrim is available at leading retailers as an OTC weight loss aid
Scientific evidence of efficacy for weight-loss and a known mode of action (11lbs weight loss over 45 days)
![Page 20: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/20.jpg)
zipp® Slenderize statementsZotrim; the leading natural weight loss aid with scientific proof
Supports healthy weight loss
Working with you to help youWorking with you to help you Eat less during mealsEat less during meals Snack less between meals Snack less between meals
Recommend three servings per day of Slenderize or Zotrim tablets as part of a healthy diet and exercise programme
![Page 21: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/21.jpg)
Summary Excellent data on weight-loss
Enables strong claims
Dual approach: pills plus products
Opportunity Zotrim distribution outside UK
Exclusive ingredient supply for
other products
![Page 22: The Food and Drink Innovation Network Foods That Manage Weight 28 th June 2007 CASE STUDY: SLENDERIZE Dr Trevor Jarman, Natures Remedies Ltd.](https://reader031.fdocuments.us/reader031/viewer/2022032311/56649daa5503460f94a97b52/html5/thumbnails/22.jpg)
For further information, please visit us at:
www.zotrim.com
www.zipp-me.co.uk