The Effect of Ultra-High Molecular Weight Polyethylene Wear Debris on MG63 Osteosarcoma Cells in...

The Effect of Ultra-High Molecular Weight Polyethylene Wear Debris on MG63 Osteosarcoma Cells in Vitro*

by D. D. DEAN, Z. SCHWARTZ, Y. LIU, C. R. BLANCHARD, C. M. AGRAWAL, J. D. MABREY, V. L. SYLVIA, C. H. LOHMANN, and B. D. BOYAN

J Bone Joint Surg AmVolume 81(4):452-61

April 1, 1999

©1999 by The Journal of Bone and Joint Surgery, Inc.

Figs. 1-A and 1-B: Scanning electron micrographs of ultra-high molecular weight polyethylene particles isolated from tissue obtained at the revision procedures (original magnification x 1000

and bar = 10.0 micrometers for Fig. 1-A; original magnification x ...

D. D. DEAN et al. J Bone Joint Surg Am 1999;81:452-61


Fig. 2 Distribution of the sizes, expressed as equivalent circle diameters in micrometers, of the particles of wear debris isolated from tissue obtained at the revision procedures.



Fig. 3 Effect of ultra-high molecular weight polyethylene particles on the number of MG63 cells.



Fig. 4 Comparison of the effects of ultra-high molecular weight polyethylene particles from granulomatous tissue and the insoluble residue from control tissue on the number of cells (A)

and the alkaline-phosphatase-specific activity (B).



Fig. 5 Effect of ultra-high molecular weight polyethylene particles on [3H]-thymidine incorporation by MG63 cells.



Fig. 6 Effect of ultra-high molecular weight polyethylene particles on alkaline-phosphatase-specific activity of MG63 cells.



Fig. 7 Effect of ultra-high molecular weight polyethylene particles on osteocalcin production by MG63 cells.



Fig. 8 Effect of ultra-high molecular weight polyethylene particles on percent collagen production by MG63 cells.



Fig. 9 Effect of ultra-high molecular weight polyethylene particles on [35S]-sulfate incorporation by MG63 cells.



Fig. 10 Effect of ultra-high molecular weight polyethylene particles on prostaglandin-E2 production by MG63 cells.



The Effect of Ultra-High Molecular Weight Polyethylene Wear Debris on MG63 Osteosarcoma Cells in...

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