The Dog As Surrogate Clinical Model for

Human Malignant Melanoma NCI Comparative Melanoma Tumor Board

January 11, 2013

The National Institutes of Health, Bethesda, Maryland The Cloister, Building 60, Room 142

Thank you to our participating co-sponsors

The  National  Institutes  of  Health

Canine Comparative Oncology

Genomics Consortium CCOGC

The Dog As Surrogate Clinical Model for Human Malignant Melanoma NCI Comparative Melanoma Tumor Board

The NIH Cloister, Building 60, Bethesda, MD January 11, 2013

AGENDA Friday – January 11, 2013 8:15am-8:50am Introduction (Mark Simpson, D.V.M., Ph.D.) Tumor Board Pathology Consensus Statement - (Stephen Hewitt, M.D., Ph.D.) 8:50am-9:00am Participant Discussion Comparative Clinical Diagnosis and Management 9:00am-9:25am Canine Melanomas - (Michael Kent, D.V.M.) 9:25am-9:50am Human Melanomas - (Gary K. Schwartz, M.D.) 9:50am-10:05am Participant Discussion 10:05am-10:15am Break Comparative Melanoma Cancer Genetics 10:15am-10:40am Canine Melanoma – (Jeff Trent, Ph.D.) 10:40am-11:05am Human Melanoma - (Marcus Bosenberg, M.D., Ph.D.) 11:05am-11:20am Participant Discussion Comparative Pathways to New Therapeutic Directions 11:20am-11:50am Human Melanoma Clinical Trials: Future Directions and Unmet Needs (Patricia LoRusso, D.O.) 11:50am-12:00pm Break WORKING LUNCH (noon-1:00pm) Lunch Presentations – Comparative Oncology: Spontaneous Melanoma for Piloting New Therapeutics noon-12:25pm Drug Development Challenges From Industry Perspective – (Wendy Levin, M.D., M.S.) 12:25pm-12:50pm Comparative Oncology Translational Studies- Infrastructure and opportunities – (Chand Khanna, D.V.M., Ph.D.) Round Table Discussion 1:00pm-2:15pm Collaborative Approaches – (All Attendees) 2:15pm-2:30pm Summary and Closing Statements – (Chand Khanna, D.V.M., Ph.D., Mark Simpson, D.V.M., Ph.D., Stephen Hewitt, M.D., Ph.D.)

NCI Comparative Melanoma Tumor Board Pathologists

* R. Mark Simpson, D.V.M., Ph.D. National Cancer Institute Bethesda, MD

* Stephen M. Hewitt, M.D., Ph.D. National Cancer Institute Bethesda, MD

* Joshua D. Webster, D.V.M., Ph.D. National Cancer Institute Bethesda, MD

* Jaime Rodriguez-Canales, M.D. National Cancer Institute Bethesda, MD

* Joy Gary, D.V.M. National Cancer Institute Bethesda, MD

Boris C. Bastian, M.D., Ph.D. University of California, San Francisco San Francisco, CA

Marcus W. Bosenberg, M.D., Ph.D. Yale University School of Medicine New Haven, CT

Barbara J. Davis, V.M.D., Ph.D. Davis Toxicologic Pathology Consulting Harvard, MA

D. Glen Esplin, D.V.M., Ph.D. ARUP Laboratories, University of Utah Salt Lake City, UT

Michael H. Goldschmidt, B.V.M.S, M.Sc. University of Pennsylvania Philadelphia, PA

Matti Kiupel, Dr. Med. Vet, Ph.D. Michigan State University East Lansing, MI

Chyi-Chia Richard Lee, M.D., Ph.D. National Cancer Institute Bethesda, MD

Donald J. Meuten, D.V.M., Ph.D. North Carolina State University Raleigh, NC

Alfredo Alberto Molinolo, M.D., Ph.D. National Institute of Dental and Craniofacial Rsrch Bethesda, MD

Adriano Piris, M.D. Massachusetts General Hospital Harvard Medical School Boston, MA

Manju Prasad, M.D., MBBS Yale University New Haven, CT

Victor G. Prieto, M.D., Ph.D. MD Anderson Cancer Center University of Texas Houston, TX

Rebecca C. Smedley, D.V.M., M.S. Michigan State University, DCPAH East Lansing, MI

Miriam Anver, D.V.M., Ph.D. Frederick National Laboratory for Cancer Research Frederick, MD

Jerrold M. Ward, D.V.M., Ph.D. Global VetPathology Gaithersburg, MD

* Tumor Board Organizers

The Dog As Surrogate Clinical Model for Human Malignant Melanoma

NCI Comparative Melanoma Tumor Board Friday, January 11, 2013

NIH Cloister, Bldg. 60, Bethesda, MD ATTENDEES Miriam Anver, D.V.M., Ph.D., Frederick National Laboratory for Cancer Research Nicholas Bacon, D.V.M. University of Florida Philip Bergman, D.V.M., Ph.D. Veterinary Clinics of America -Antech Marcus W. Bosenberg, M.D., Ph.D. Yale University School of Medicine Matthew Breen, Ph.D. North Carolina State University Barbara Cohen Animal Cancer Foundation Catherine Conway, Ph.D. National Cancer Institute Conway, Catherine (NIH/NCI) [F] Sarah Cramer, D.V.M. Laboratory of Experimental Immunology National Cancer Institute Barbara Davis, V.M.D., Ph.D. Davis Toxicologic Pathology Consulting Jim Doroshow, M.D. Laboratory of Molecular Pharmacology National Cancer Institute D. Glen Esplin, D.V.M., Ph.D. ARUP Laboratories University of Utah Joy Gary, D.V.M. Laboratory of Cancer Biology and Genetics National Cancer Institute Michael H. Goldschmidt, B.V.M.S, M.Sc. University of Pennsylvania Ira Gordon, D.V.M. Radiation Oncology Branch National Cancer Institute Meenhard Herlyn, D.V.M., D.Sc. Wistar Institute Cancer Center

Stephen M. Hewitt, M.D., Ph.D. Laboratory of Pathology National Cancer Institute John Hickerson Laboratory of Cancer Biology and Genetics National Cancer Institute Shelley Hoover Laboratory of Cancer Biology and Genetics National Cancer Institute Michael Kent, D.V.M. University of California, Davis Chand Khanna, D.V.M., Ph.D. Pediatric Oncology Branch National Cancer Institute Matti Kiupel, Dr. Med. Vet, Ph.D. Michigan State University Shivaani Kummar, M.D. Laboratory of Molecular Pharmacology National Cancer Institute Chyi-Chia Richard Lee, M.D., Ph.D. Laboratory of Pathology National Cancer Institute Wendy Levin, M.D., M.S. Pfizer, Inc. Patricia LoRusso, D.O. Karmanos Cancer Institute and Wayne State University School of Medicine Christina Mazcko Pediatric Oncology Branch National Cancer Institute Taha Merghoub, Ph.D. Memorial Sloan-Kettering Cancer Center Glenn Merlino, Ph.D. Laboratory of Cancer Biology and Genetics National Cancer Institute Donald J. Meuten, D.V.M., Ph.D. North Carolina State University

Helen Michael, D.V.M. Laboratory of Cancer Biology and Genetics National Cancer Institute Alfredo Alberto Molinolo, M.D., Ph.D. Oral & Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research Melissa Paoloni, D.V.M. Pediatric Oncology Branch National Cancer Institute Adriano Piris, M.D. Massachusetts General Hospital Harvard Medical School Gerald Post, D.V.M., M.E.M. The Veterinary Cancer Center Manju Prasad, M.D., MBBS Yale University Victor G. Prieto, M.D., Ph.D. MD Anderson Cancer Center University of Texas Gary Schwartz, M.D. Memorial Sloan-Kettering Cancer Center Heather Shive, D.V.M., Ph.D. Transplantation and Immunology Branch National Cancer Institute R. Mark Simpson, D.V.M., Ph.D. Laboratory of Cancer Biology and Genetics National Cancer Institute

Rebecca C. Smedley, D.V.M., M.S. Michigan State University, DCPAH Howard Streicher, M.D. Investigational Drug Branch National Cancer Institute Heather Tillman, D.V.M. Cancer and Cell Biology Branch National Cancer Institute Jeff Trent, Ph.D. Translational Genomics Research Institute David Vail, D.V.M. University of Wisconsin, Madison Jerrold Ward, D.V.M., Ph.D. Global VetPathology Joshua D. Webster, D.V.M., Ph.D. Genentech, Inc. Bih-Rong Wei, Ph.D. Laboratory of Cancer Biology and Genetics National Cancer Institute Kevin Woolard, D.V.M., Ph.D. Neuro-oncology Branch National Cancer Institute Leah Zadrozny, D.V.M. Laboratory of Cardiac Energetics National Heart, Lung and Blood Institute