The Cell Cycle Year 12 Biology C9. Draw a circle to the left hand side of the page.
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Transcript of The Cell Cycle Year 12 Biology C9. Draw a circle to the left hand side of the page.
The Cell Cycle
Year 12 Biology C9
Draw a circle to the left hand side of the page
Divide the circle into four sections
Divide the right-hand quarter into fourths.
Label the quarters
G1 Phase
S Phase
G2 Phase
M
Phase
Label the phases of M-phase (Mitosis)
G1 Phase
S Phase
G2 Phase
M
Phase
Prophase
Metaphase
AnaphaseTelophase
Add details of each phase of mitosis.
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Add details of each phase of mitosis.
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Add details of each phase of mitosis.
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Add details of each phase of mitosis.
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Add details of each phase of the cell cycle
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Add details of each phase of the cell cycle
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
Add details of each phase of the cell cycle
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Add details of each phase of the cell cycle
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
Add checkpoints
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
Check for DNA Damage
Cell big enough?
Add checkpoints
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
Check for DNA SynthesisCell size
Check for DNA Damage
Cell big enough?
Add checkpoints
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
Check for DNA SynthesisCell size
Check for DNA Damage
Cell big enough?
Add checkpoints
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
Check for DNA SynthesisCell size
Hold to break down cyclins
Check for DNA Damage
Cell big enough?
Add checkpoints
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
Check for DNA SynthesisCell size
Pause to break down cyclins
Check for DNA Damage
Cell big enough?
Add checkpoints
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
Check for DNA SynthesisCell size
Pause to break down cyclins
Check for DNA Damage
Cell big enough?
Add external growth factors…
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
Mitosis promoting factor (e.g. hormone)
Nucleus
Nucleus makes internal regulators..
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
Mitosis promoting factor (e.g. hormone)
Nucleus
Kinase Cyclin
Nucleus makes internal regulators..
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
Mitosis promoting factor (e.g. hormone)
Nucleus
CDK complex
CDKs build up…
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
CDK complex
CDKs build up…
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
CDK complex
CDKs build up…
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
CDK complex
CDKs build up…
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
CDK complex
CDKs build up…
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
CDK complex
CDKs start to break down…
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
CDK complex
CDKs start to break down…
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
CDK complex
Only when all CDK has broken down can the cell proceed to Metaphase…
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
Only when all CDK has broken down can the cell proceed to Metaphase…
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
G0 phase
At telophase the cell can go into G0 phase (and remain there) or continue on to the cell cycle…
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
G0 phase
Differentiation
The cell may then become differentiated into any one of the 200 body cells in humans..
Role of inhibitors…•p27blocks the build up of CDK complex during G1 and prevents movement to S phase
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
CDK complexp27
Role of inhibitors…•p27blocks the build up of CDK complex during G1 and prevents movement to S phase•p53 stops cell cycle at any point if DNA is damaged.
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
CDK complexp53
p53
p53
Role of inhibitors…If mutations occur to inhibitors – cancer may result i.e. uncontrolled cell cycle.
G1 Phase
S Phase
G2 Phase
Prophase
Metaphase
AnaphaseTelophase
Cell growth
Energy
Organelles
DNA Synthesis
Cell Growth
Energy
CDK complex