The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 ›...

55
The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained! Brought to you by: The Center for Bio Individualized Medicine™ Finding Answers Through Genetics and Integrative Medicine Dr. Jess P. Armine Shawn Bean, B.S. [email protected] (610) 449 9716 1

Transcript of The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 ›...

Page 1: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

The BRAINWALLAnxiety Depression and Neurotransmitters Explained

Brought to you by The Center for Bio Individualized MedicinetradeFinding Answers Through Genetics and Integrative

MedicineDr Jess P ArmineShawn Bean BS

bioindividualmedgmailcom(610) 449 9716

1

The Brain Wall Will Help You Understand

bull The neurotransmitters and their function

bull The relationship between the parts of the brain and their functiondysfunction

bull The basis of ADD OCD Anxiety Depression Bipolar Disorder Schizophrenia

bull To make you informed and empowered

2

copy Dr Jess Armine 2015

3

copy Dr Jess Armine 2015

NEUROTRANSMITTERS

What are Neurotransmitters

Why are Neurotransmitters Important

4

copy Dr Jess Armine 2015

Synapse

(c) Dr Jess P Armine 2015

Neurotransmitter

5

6

copy Dr Jess Armine 2015

7

copy Dr Jess Armine 2015

GABAGamma Amino Butyric Acid

Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid

8

copy Dr Jess Armine 2015

AREAS OF THE BRAIN

Their Functions and the Associated Symptoms of Dysfunctions

9

copy Dr Jess Armine 2015

10

copy Dr Jess Armine 2015

11

copy Dr Jess Armine 2015

12

copy Dr Jess Armine 2015

13

copy Dr Jess Armine 2015

14

copy Dr Jess Armine 2015

PSYCHO (THE MIND) AND SOMA (THE BODY)

The relationship between

The History of Bio-Individualized Medicine

15

copy Dr Jess Armine 2015

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 2: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

The Brain Wall Will Help You Understand

bull The neurotransmitters and their function

bull The relationship between the parts of the brain and their functiondysfunction

bull The basis of ADD OCD Anxiety Depression Bipolar Disorder Schizophrenia

bull To make you informed and empowered

2

copy Dr Jess Armine 2015

3

copy Dr Jess Armine 2015

NEUROTRANSMITTERS

What are Neurotransmitters

Why are Neurotransmitters Important

4

copy Dr Jess Armine 2015

Synapse

(c) Dr Jess P Armine 2015

Neurotransmitter

5

6

copy Dr Jess Armine 2015

7

copy Dr Jess Armine 2015

GABAGamma Amino Butyric Acid

Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid

8

copy Dr Jess Armine 2015

AREAS OF THE BRAIN

Their Functions and the Associated Symptoms of Dysfunctions

9

copy Dr Jess Armine 2015

10

copy Dr Jess Armine 2015

11

copy Dr Jess Armine 2015

12

copy Dr Jess Armine 2015

13

copy Dr Jess Armine 2015

14

copy Dr Jess Armine 2015

PSYCHO (THE MIND) AND SOMA (THE BODY)

The relationship between

The History of Bio-Individualized Medicine

15

copy Dr Jess Armine 2015

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 3: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

3

copy Dr Jess Armine 2015

NEUROTRANSMITTERS

What are Neurotransmitters

Why are Neurotransmitters Important

4

copy Dr Jess Armine 2015

Synapse

(c) Dr Jess P Armine 2015

Neurotransmitter

5

6

copy Dr Jess Armine 2015

7

copy Dr Jess Armine 2015

GABAGamma Amino Butyric Acid

Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid

8

copy Dr Jess Armine 2015

AREAS OF THE BRAIN

Their Functions and the Associated Symptoms of Dysfunctions

9

copy Dr Jess Armine 2015

10

copy Dr Jess Armine 2015

11

copy Dr Jess Armine 2015

12

copy Dr Jess Armine 2015

13

copy Dr Jess Armine 2015

14

copy Dr Jess Armine 2015

PSYCHO (THE MIND) AND SOMA (THE BODY)

The relationship between

The History of Bio-Individualized Medicine

15

copy Dr Jess Armine 2015

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 4: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

NEUROTRANSMITTERS

What are Neurotransmitters

Why are Neurotransmitters Important

4

copy Dr Jess Armine 2015

Synapse

(c) Dr Jess P Armine 2015

Neurotransmitter

5

6

copy Dr Jess Armine 2015

7

copy Dr Jess Armine 2015

GABAGamma Amino Butyric Acid

Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid

8

copy Dr Jess Armine 2015

AREAS OF THE BRAIN

Their Functions and the Associated Symptoms of Dysfunctions

9

copy Dr Jess Armine 2015

10

copy Dr Jess Armine 2015

11

copy Dr Jess Armine 2015

12

copy Dr Jess Armine 2015

13

copy Dr Jess Armine 2015

14

copy Dr Jess Armine 2015

PSYCHO (THE MIND) AND SOMA (THE BODY)

The relationship between

The History of Bio-Individualized Medicine

15

copy Dr Jess Armine 2015

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 5: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Synapse

(c) Dr Jess P Armine 2015

Neurotransmitter

5

6

copy Dr Jess Armine 2015

7

copy Dr Jess Armine 2015

GABAGamma Amino Butyric Acid

Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid

8

copy Dr Jess Armine 2015

AREAS OF THE BRAIN

Their Functions and the Associated Symptoms of Dysfunctions

9

copy Dr Jess Armine 2015

10

copy Dr Jess Armine 2015

11

copy Dr Jess Armine 2015

12

copy Dr Jess Armine 2015

13

copy Dr Jess Armine 2015

14

copy Dr Jess Armine 2015

PSYCHO (THE MIND) AND SOMA (THE BODY)

The relationship between

The History of Bio-Individualized Medicine

15

copy Dr Jess Armine 2015

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 6: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

6

copy Dr Jess Armine 2015

7

copy Dr Jess Armine 2015

GABAGamma Amino Butyric Acid

Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid

8

copy Dr Jess Armine 2015

AREAS OF THE BRAIN

Their Functions and the Associated Symptoms of Dysfunctions

9

copy Dr Jess Armine 2015

10

copy Dr Jess Armine 2015

11

copy Dr Jess Armine 2015

12

copy Dr Jess Armine 2015

13

copy Dr Jess Armine 2015

14

copy Dr Jess Armine 2015

PSYCHO (THE MIND) AND SOMA (THE BODY)

The relationship between

The History of Bio-Individualized Medicine

15

copy Dr Jess Armine 2015

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 7: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

7

copy Dr Jess Armine 2015

GABAGamma Amino Butyric Acid

Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid

8

copy Dr Jess Armine 2015

AREAS OF THE BRAIN

Their Functions and the Associated Symptoms of Dysfunctions

9

copy Dr Jess Armine 2015

10

copy Dr Jess Armine 2015

11

copy Dr Jess Armine 2015

12

copy Dr Jess Armine 2015

13

copy Dr Jess Armine 2015

14

copy Dr Jess Armine 2015

PSYCHO (THE MIND) AND SOMA (THE BODY)

The relationship between

The History of Bio-Individualized Medicine

15

copy Dr Jess Armine 2015

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 8: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

GABAGamma Amino Butyric Acid

Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid

8

copy Dr Jess Armine 2015

AREAS OF THE BRAIN

Their Functions and the Associated Symptoms of Dysfunctions

9

copy Dr Jess Armine 2015

10

copy Dr Jess Armine 2015

11

copy Dr Jess Armine 2015

12

copy Dr Jess Armine 2015

13

copy Dr Jess Armine 2015

14

copy Dr Jess Armine 2015

PSYCHO (THE MIND) AND SOMA (THE BODY)

The relationship between

The History of Bio-Individualized Medicine

15

copy Dr Jess Armine 2015

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 9: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

AREAS OF THE BRAIN

Their Functions and the Associated Symptoms of Dysfunctions

9

copy Dr Jess Armine 2015

10

copy Dr Jess Armine 2015

11

copy Dr Jess Armine 2015

12

copy Dr Jess Armine 2015

13

copy Dr Jess Armine 2015

14

copy Dr Jess Armine 2015

PSYCHO (THE MIND) AND SOMA (THE BODY)

The relationship between

The History of Bio-Individualized Medicine

15

copy Dr Jess Armine 2015

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 10: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

10

copy Dr Jess Armine 2015

11

copy Dr Jess Armine 2015

12

copy Dr Jess Armine 2015

13

copy Dr Jess Armine 2015

14

copy Dr Jess Armine 2015

PSYCHO (THE MIND) AND SOMA (THE BODY)

The relationship between

The History of Bio-Individualized Medicine

15

copy Dr Jess Armine 2015

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 11: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

11

copy Dr Jess Armine 2015

12

copy Dr Jess Armine 2015

13

copy Dr Jess Armine 2015

14

copy Dr Jess Armine 2015

PSYCHO (THE MIND) AND SOMA (THE BODY)

The relationship between

The History of Bio-Individualized Medicine

15

copy Dr Jess Armine 2015

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 12: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

12

copy Dr Jess Armine 2015

13

copy Dr Jess Armine 2015

14

copy Dr Jess Armine 2015

PSYCHO (THE MIND) AND SOMA (THE BODY)

The relationship between

The History of Bio-Individualized Medicine

15

copy Dr Jess Armine 2015

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 13: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

13

copy Dr Jess Armine 2015

14

copy Dr Jess Armine 2015

PSYCHO (THE MIND) AND SOMA (THE BODY)

The relationship between

The History of Bio-Individualized Medicine

15

copy Dr Jess Armine 2015

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 14: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

14

copy Dr Jess Armine 2015

PSYCHO (THE MIND) AND SOMA (THE BODY)

The relationship between

The History of Bio-Individualized Medicine

15

copy Dr Jess Armine 2015

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 15: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

PSYCHO (THE MIND) AND SOMA (THE BODY)

The relationship between

The History of Bio-Individualized Medicine

15

copy Dr Jess Armine 2015

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 16: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

In The Beginning There Was

PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester

advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function

R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915

Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903

copy Dr Jess Armine 2015

16

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 17: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

17

Then The Neuro-Endo-ImmuneSuperSystem

copy Dr Jess Armine 2015

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 18: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Neuro-Endo-Immunologywwwneuroreliefcom

18

copy Dr Jess Armine 2015

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 19: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Constant ChatterOne System Affects the Other

NTrsquosNeurology

Hormones(Endocirine)

CytokinesChemokines

(Immune)

wwwneuroreliefcom

19

copy Dr Jess Armine 2015

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 20: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Epigenetics Methylation Nutrigenomics

NEI

Mitochondrial Function

Cell Wall Integrity

20

copy Dr Jess Armine 2015

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 21: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Balancing Neurotransmitters

Neurotransmitter Imbalances can cause in part or in full

Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc

Balancing Neurotransmitters results in

Better mood

Better sleep

Improve brain fog

Increased energy

21

copy Dr Jess Armine 2015

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 22: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

How Considertest all parameters of

Bio-Individualized Medicine

Discover the root Cause(s)

Identify the downstream effects

Primum non nocere

First do no harm

Treat the body as a whole not

Just the genes

Just the NTrsquos

Just the (fill in the blank here)

Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)

Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more

22

copy Dr Jess Armine 2015

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 23: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory

amp Visual)

Mom initially contacted presenter with the possible need for Irlen Glasses

Also co ldquobad gutrdquo

After questioning the hallucinations were discovered

Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness

23

copy Dr Jess Armine 2015

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 24: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

What Is Irlen Syndromewwwirlencom

Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not

currently identified by other standardized educational or medical tests

Irlen Syndrome can affect many different areas including

Academic and work performance

Behavior

Attention

Ability to sit still

Concentration

24

copy Dr Jess Armine 2015

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 25: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Polymorphisms (SNPs) should raise your index of suspicion in certain areas

SOD suspect mitochondrial involvement

PON1 Organophosphates (Patient lives in a farming community)

Suspect difficulty in metabolizing aldehydes

Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes

25

copy Dr Jess Armine 2015

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 26: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))

COMT=ExcitotoxicityDifficulty in metabolizing catecholamines

Glutamic Acid decarboxylase

The ldquoGeneral Anxiety Disorderrdquo Genes

26

copy Dr Jess Armine 2015

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 27: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X

AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression

Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders

27

copy Dr Jess Armine 2015

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 28: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

FUT2 amp IGA

IgA Snps

Tendency toward food allergies especially with leaky gut syndrome

FUT2 has possible contribution to imbalances in the gut microbiome and B12

28

copy Dr Jess Armine 2015

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 29: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

MTHFR

Methylation pathway issues

Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression

29

copy Dr Jess Armine 2015

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 30: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Mitochondrial Complex 1

NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain

30

copy Dr Jess Armine 2015

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 31: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

SNPs Indicate Probable Issue in the Following Areas

Neurotransmittersbull COMTbull GADbull Others MAO

Leaky Gut Syndromebull IgAbull SHMTbull FUT2

Aldehyde Metabolismbull NAT

Methylationbull MTHFRbull MTRR

Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS

Hallucinationsmood issues based on Neurotransmitter balance

Yeast will produce Acetyl Aldehyde-Stool test

Oxidative Stress will block pathway preventing ATP production

Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia

31

copy Dr Jess Armine 2015

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 32: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

NEUROTRANSMITTER BALANCE

Urinary Neurotransmitter Testing

32

copy Dr Jess Armine 2015

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 33: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments

Usual Statements I Hear

There is no peer reviewed research supporting their use

The measurements do not represent CNS

Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders

My Usual Responses

Urinary (or serum) NTrsquos are both CNS and PNS

Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data

BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)

33

copy Dr Jess Armine 2015

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 34: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

34

copy Dr Jess Armine 2015

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 35: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

BIOMARKERSThe Key Concept

Townsend Letter 2009

35

copy Dr Jess Armine 2015

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 36: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Our Patienthellip

InhibitoryExcitatory Balance Visually compare the rough levels of

inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)

The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos

The rdquoNet Resultrdquo is an excited nervous system

Hallucinations Always from over excitation Classically high dopamine causes

hallucinations (but not always) Glutamate Histamine PEA

Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination

Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds

Adrenal Fatigue

36

copy Dr Jess Armine 2015

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 37: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

WHO IS UPREGULATING THE NERVOUS SYSTEM

Root Cause Analysis

37

copy Dr Jess Armine 2015

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 38: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Root CausehellipThink NEI

Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others

38

copy Dr Jess Armine 2015

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 39: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Leaky Gut Syndrome

Net ResulthellipINFLAMMATION

39

copy Dr Jess Armine 2015

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 40: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Microbial Involvement

Consider Lyme Disease Co-Infections Strep Viruses parasites

40

copy Dr Jess Armine 2015

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 41: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Labs and Dx

Lab Child was extensively

tested and found to have antibodies to Lyme Yeast and HHV6

Numerous food allergies by IgG testing

Concentrations were in Gluten Dairy and Yeast areas

41

copy Dr Jess Armine 2015

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 42: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Western Blot for Lyme testingMDL Labs

Lyme Western Blot Negative

But is it really negative

42

copy Dr Jess Armine 2015

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 43: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Donrsquot Believe the ComputerIgG

Reports 1 when I see 7 bands

With Human Eyes the WB meets CDC criteria

Reports zero when I see 3 bands

43

copy Dr Jess Armine 2015

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 44: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Lyme Cytokines

Note the Baseline First

If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme

If baseline is high upregulation of the stimulated cytokines may be false positive

44

copy Dr Jess Armine 2015

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 45: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Considerations

Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations

Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations

Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations

Answer Yes to all of the above

45

copy Dr Jess Armine 2015

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 46: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

TreatmentStep 1 GI RepairNT Balance

Gluten Free diet

Casein Free diet

Soy Free diet

Demulcent herbs to recreate the mucus layer

Phospholipids to support cellular repair

Digestive enzymes to assure full breakdown of foods and prevent creation of antigens

DAO enzyme to help break down histamine

Probiotics (soil based w S Boulardii)

Phenylated GABA and 5HTP to counterbalance excitation

L Theanine to block glutamate receptors

Covered the basics

At the time oxalates were not on the radar

46

copy Dr Jess Armine 2015

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 47: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

TreatmentStep 2 Kill the Bugs

Child was co treated by myself and an integrative pediatrician

GI Repair program was conducted for a period of 3 months

Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)

The parents were given full information pros cons etc by the pediatrician and myself

The parents chose the latter

47

copy Dr Jess Armine 2015

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 48: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

TreatmentStep 3 Retest

Two months after treatment started testing was done again at the same lab

All results were negative

All symptoms were gone

48

copy Dr Jess Armine 2015

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 49: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

She is now 12Progressing through puberty without issues

Maintains her diet and lives a normal ldquotweenrdquo lifestyle

Prospect A life on antipsychotic meds

Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections

Result A life saved

49

copy Dr Jess Armine 2015

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 50: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

What Have We Learned

NT Imbalance can cause all manner of maladies

NT imbalance can come from numerous root causes singularly or in combination

You MUST look at each personrsquos condition INDIVIDUALLY

All parameters of Bio-Individualized Medicine MUST be considered

No singe parameter should be treated in a vacuum The person MUST be treated as a whole

Your Health Care Provider must act like ahellip

A Detective

50

copy Dr Jess Armine 2015

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 51: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

How To Get Your Own Brainwall PosterDesign Your Victory

The Art Work of Jesse Armine

wwwdesignyourvictorycom

51

copy Dr Jess Armine 2015

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 52: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Lyme Disease Panel(USA only- email us if you are outside the USA for more info)

CBIM Panel (MDL Labs) Our Panel Includes

Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR

A Western Blot that you can see with your own eyes

An Interpretive consultation with an experienced unbiased health care provider

Your Cost $79900

The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)

IgeneX Initial Lyme Panel

Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood

Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia

FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody

No Interpretive Consultation

Your Cost $123000

The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation

52

copy Dr Jess Armine 2015

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 53: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested

Epinephrine

Norepinephrine

Dopamine

Serotonin

Glycine

GABA

Glutamate

PEA

Histamine

An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos

Your Cost $441

The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)

53

copy Dr Jess Armine 2015

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 54: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

How To Contact Us ampTake Advantage of CBIMrsquos Panels

Dr Armine and Shawn Bean can be obtained inside and outside the USA by

E-mail bioindividualmedgmailcom

Fill in contact form at wwwmethylationsupportcom

Phone 610 449 9716

To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel

Contact the Patient Coordinator at

E-mail bioindividualmedgmailcom

Phone 610 449 9716

copy Dr Jess Armine 2015

54

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015

Page 55: The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 › brain-wall-lect... · The BRAINWALL Anxiety, Depression, and Neurotransmitters Explained!

Evidenced Based References

bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1

bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml

bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml

bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml

bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543

55

copy Dr Jess Armine 2015