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Transcript of The BRAINWALL - Home - Methylation Support › wp-content › uploads › 2015 › 07 ›...
The BRAINWALLAnxiety Depression and Neurotransmitters Explained
Brought to you by The Center for Bio Individualized MedicinetradeFinding Answers Through Genetics and Integrative
MedicineDr Jess P ArmineShawn Bean BS
bioindividualmedgmailcom(610) 449 9716
1
The Brain Wall Will Help You Understand
bull The neurotransmitters and their function
bull The relationship between the parts of the brain and their functiondysfunction
bull The basis of ADD OCD Anxiety Depression Bipolar Disorder Schizophrenia
bull To make you informed and empowered
2
copy Dr Jess Armine 2015
3
copy Dr Jess Armine 2015
NEUROTRANSMITTERS
What are Neurotransmitters
Why are Neurotransmitters Important
4
copy Dr Jess Armine 2015
Synapse
(c) Dr Jess P Armine 2015
Neurotransmitter
5
6
copy Dr Jess Armine 2015
7
copy Dr Jess Armine 2015
GABAGamma Amino Butyric Acid
Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid
8
copy Dr Jess Armine 2015
AREAS OF THE BRAIN
Their Functions and the Associated Symptoms of Dysfunctions
9
copy Dr Jess Armine 2015
10
copy Dr Jess Armine 2015
11
copy Dr Jess Armine 2015
12
copy Dr Jess Armine 2015
13
copy Dr Jess Armine 2015
14
copy Dr Jess Armine 2015
PSYCHO (THE MIND) AND SOMA (THE BODY)
The relationship between
The History of Bio-Individualized Medicine
15
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
The Brain Wall Will Help You Understand
bull The neurotransmitters and their function
bull The relationship between the parts of the brain and their functiondysfunction
bull The basis of ADD OCD Anxiety Depression Bipolar Disorder Schizophrenia
bull To make you informed and empowered
2
copy Dr Jess Armine 2015
3
copy Dr Jess Armine 2015
NEUROTRANSMITTERS
What are Neurotransmitters
Why are Neurotransmitters Important
4
copy Dr Jess Armine 2015
Synapse
(c) Dr Jess P Armine 2015
Neurotransmitter
5
6
copy Dr Jess Armine 2015
7
copy Dr Jess Armine 2015
GABAGamma Amino Butyric Acid
Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid
8
copy Dr Jess Armine 2015
AREAS OF THE BRAIN
Their Functions and the Associated Symptoms of Dysfunctions
9
copy Dr Jess Armine 2015
10
copy Dr Jess Armine 2015
11
copy Dr Jess Armine 2015
12
copy Dr Jess Armine 2015
13
copy Dr Jess Armine 2015
14
copy Dr Jess Armine 2015
PSYCHO (THE MIND) AND SOMA (THE BODY)
The relationship between
The History of Bio-Individualized Medicine
15
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
3
copy Dr Jess Armine 2015
NEUROTRANSMITTERS
What are Neurotransmitters
Why are Neurotransmitters Important
4
copy Dr Jess Armine 2015
Synapse
(c) Dr Jess P Armine 2015
Neurotransmitter
5
6
copy Dr Jess Armine 2015
7
copy Dr Jess Armine 2015
GABAGamma Amino Butyric Acid
Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid
8
copy Dr Jess Armine 2015
AREAS OF THE BRAIN
Their Functions and the Associated Symptoms of Dysfunctions
9
copy Dr Jess Armine 2015
10
copy Dr Jess Armine 2015
11
copy Dr Jess Armine 2015
12
copy Dr Jess Armine 2015
13
copy Dr Jess Armine 2015
14
copy Dr Jess Armine 2015
PSYCHO (THE MIND) AND SOMA (THE BODY)
The relationship between
The History of Bio-Individualized Medicine
15
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
NEUROTRANSMITTERS
What are Neurotransmitters
Why are Neurotransmitters Important
4
copy Dr Jess Armine 2015
Synapse
(c) Dr Jess P Armine 2015
Neurotransmitter
5
6
copy Dr Jess Armine 2015
7
copy Dr Jess Armine 2015
GABAGamma Amino Butyric Acid
Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid
8
copy Dr Jess Armine 2015
AREAS OF THE BRAIN
Their Functions and the Associated Symptoms of Dysfunctions
9
copy Dr Jess Armine 2015
10
copy Dr Jess Armine 2015
11
copy Dr Jess Armine 2015
12
copy Dr Jess Armine 2015
13
copy Dr Jess Armine 2015
14
copy Dr Jess Armine 2015
PSYCHO (THE MIND) AND SOMA (THE BODY)
The relationship between
The History of Bio-Individualized Medicine
15
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Synapse
(c) Dr Jess P Armine 2015
Neurotransmitter
5
6
copy Dr Jess Armine 2015
7
copy Dr Jess Armine 2015
GABAGamma Amino Butyric Acid
Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid
8
copy Dr Jess Armine 2015
AREAS OF THE BRAIN
Their Functions and the Associated Symptoms of Dysfunctions
9
copy Dr Jess Armine 2015
10
copy Dr Jess Armine 2015
11
copy Dr Jess Armine 2015
12
copy Dr Jess Armine 2015
13
copy Dr Jess Armine 2015
14
copy Dr Jess Armine 2015
PSYCHO (THE MIND) AND SOMA (THE BODY)
The relationship between
The History of Bio-Individualized Medicine
15
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
6
copy Dr Jess Armine 2015
7
copy Dr Jess Armine 2015
GABAGamma Amino Butyric Acid
Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid
8
copy Dr Jess Armine 2015
AREAS OF THE BRAIN
Their Functions and the Associated Symptoms of Dysfunctions
9
copy Dr Jess Armine 2015
10
copy Dr Jess Armine 2015
11
copy Dr Jess Armine 2015
12
copy Dr Jess Armine 2015
13
copy Dr Jess Armine 2015
14
copy Dr Jess Armine 2015
PSYCHO (THE MIND) AND SOMA (THE BODY)
The relationship between
The History of Bio-Individualized Medicine
15
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
7
copy Dr Jess Armine 2015
GABAGamma Amino Butyric Acid
Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid
8
copy Dr Jess Armine 2015
AREAS OF THE BRAIN
Their Functions and the Associated Symptoms of Dysfunctions
9
copy Dr Jess Armine 2015
10
copy Dr Jess Armine 2015
11
copy Dr Jess Armine 2015
12
copy Dr Jess Armine 2015
13
copy Dr Jess Armine 2015
14
copy Dr Jess Armine 2015
PSYCHO (THE MIND) AND SOMA (THE BODY)
The relationship between
The History of Bio-Individualized Medicine
15
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
GABAGamma Amino Butyric Acid
Gamma-Aminobutyric acid is the chief inhibitory neurotransmitter in the mammalian central nervous systemhttpenwikipediaorgwikiGamma-Aminobutyric_acid
8
copy Dr Jess Armine 2015
AREAS OF THE BRAIN
Their Functions and the Associated Symptoms of Dysfunctions
9
copy Dr Jess Armine 2015
10
copy Dr Jess Armine 2015
11
copy Dr Jess Armine 2015
12
copy Dr Jess Armine 2015
13
copy Dr Jess Armine 2015
14
copy Dr Jess Armine 2015
PSYCHO (THE MIND) AND SOMA (THE BODY)
The relationship between
The History of Bio-Individualized Medicine
15
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
AREAS OF THE BRAIN
Their Functions and the Associated Symptoms of Dysfunctions
9
copy Dr Jess Armine 2015
10
copy Dr Jess Armine 2015
11
copy Dr Jess Armine 2015
12
copy Dr Jess Armine 2015
13
copy Dr Jess Armine 2015
14
copy Dr Jess Armine 2015
PSYCHO (THE MIND) AND SOMA (THE BODY)
The relationship between
The History of Bio-Individualized Medicine
15
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
10
copy Dr Jess Armine 2015
11
copy Dr Jess Armine 2015
12
copy Dr Jess Armine 2015
13
copy Dr Jess Armine 2015
14
copy Dr Jess Armine 2015
PSYCHO (THE MIND) AND SOMA (THE BODY)
The relationship between
The History of Bio-Individualized Medicine
15
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
11
copy Dr Jess Armine 2015
12
copy Dr Jess Armine 2015
13
copy Dr Jess Armine 2015
14
copy Dr Jess Armine 2015
PSYCHO (THE MIND) AND SOMA (THE BODY)
The relationship between
The History of Bio-Individualized Medicine
15
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
12
copy Dr Jess Armine 2015
13
copy Dr Jess Armine 2015
14
copy Dr Jess Armine 2015
PSYCHO (THE MIND) AND SOMA (THE BODY)
The relationship between
The History of Bio-Individualized Medicine
15
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
13
copy Dr Jess Armine 2015
14
copy Dr Jess Armine 2015
PSYCHO (THE MIND) AND SOMA (THE BODY)
The relationship between
The History of Bio-Individualized Medicine
15
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
14
copy Dr Jess Armine 2015
PSYCHO (THE MIND) AND SOMA (THE BODY)
The relationship between
The History of Bio-Individualized Medicine
15
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
PSYCHO (THE MIND) AND SOMA (THE BODY)
The relationship between
The History of Bio-Individualized Medicine
15
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
In The Beginning There Was
PsychoNeuroImmunology 1975 In 1975 Robert Ader and Nicholas Cohen at the University of Rochester
advanced PNI with their demonstration of classic conditioning of immune function and they subsequently coined the term psychoneuroimmunologyrdquo They demonstrated the relationship between psychiatric syndromes or symptoms and immune function
R Adler and N Cohen Behaviorally conditioned immunosuppression Psychosomatic Medicine Vol 37 Issue 4 333-340
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
Cohen S Williamson G M (1991) Stress and infectious disease in humans Psychological Bulletin 109 (1) 5ndash24 doi1010370033-290910915
Cohen S Tyrrell D A Smith A P (1991) Psychological stress and susceptibility to the common cold The New England Journal of Medicine 325 (9) 606ndash12 doi101056nejm199108293250903
copy Dr Jess Armine 2015
16
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
17
Then The Neuro-Endo-ImmuneSuperSystem
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Neuro-Endo-Immunologywwwneuroreliefcom
18
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Constant ChatterOne System Affects the Other
NTrsquosNeurology
Hormones(Endocirine)
CytokinesChemokines
(Immune)
wwwneuroreliefcom
19
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Epigenetics Methylation Nutrigenomics
NEI
Mitochondrial Function
Cell Wall Integrity
20
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Balancing Neurotransmitters
Neurotransmitter Imbalances can cause in part or in full
Anxiety Depression ADD ADHD OCD ODD Schizophrenia and a whole array of mood and thought disorders Also let us not forget that NTs run many other systems like our enteric nervous system thermogenic system (this is why SSRIrsquos sometimes help hot flashes) etc
Balancing Neurotransmitters results in
Better mood
Better sleep
Improve brain fog
Increased energy
21
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
How Considertest all parameters of
Bio-Individualized Medicine
Discover the root Cause(s)
Identify the downstream effects
Primum non nocere
First do no harm
Treat the body as a whole not
Just the genes
Just the NTrsquos
Just the (fill in the blank here)
Bio-Terrain Therapy (Foundational Treatment) AKA ldquoFoundational Treatment)
Some possible treatments Targeted Amino Acid Therapy Neuro Adaptagenic Amino Acid Therapy Co FactorsCo Enzymes Support enzyme function Balancecounter-balance NTrsquos A whole host more
22
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Case Study 8 Year Old Female with Hallucinations (Auditory Olfactory
amp Visual)
Mom initially contacted presenter with the possible need for Irlen Glasses
Also co ldquobad gutrdquo
After questioning the hallucinations were discovered
Standard work-up (Brain CT and MRI labs for thyroid CBC CMP etc) were negative for pathology or signs of obvious illness
23
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
What Is Irlen Syndromewwwirlencom
Irlen Syndrome (also referred to at times as Meares-Irlen Syndrome Scotopic Sensitivity Syndrome and Visual Stress) is a perceptual processing disorder It is not an optical problem It is a problem with the brainrsquos ability to process visual information This problem tends to run in families and is not
currently identified by other standardized educational or medical tests
Irlen Syndrome can affect many different areas including
Academic and work performance
Behavior
Attention
Ability to sit still
Concentration
24
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Polymorphisms (SNPs) should raise your index of suspicion in certain areas
SOD suspect mitochondrial involvement
PON1 Organophosphates (Patient lives in a farming community)
Suspect difficulty in metabolizing aldehydes
Yeast= Will Create ldquoMuchordquo Acetyl Aldehydes
25
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
COMT ( predisposition to Excitotoxicity) GAD (predisposition to SMI (Serious Mental Illness))
COMT=ExcitotoxicityDifficulty in metabolizing catecholamines
Glutamic Acid decarboxylase
The ldquoGeneral Anxiety Disorderrdquo Genes
26
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticismMol Psychiatry 2006 Aug11(8)752-62 Epub 2006 May 23Hettema JM1 An SS Neale MC Bukszar J van den Oord EJ Kendler KS Chen X
AbstractAbnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders Glutamic acid decarboxylase (GAD) enzymes synthesize GABA from glutamate and thus are reasonable candidate susceptibility genes for these conditions In this study we examined the GAD1 and GAD2 genes for their association with genetic risk across a range of internalizing disorders We used multivariate structural equation modeling to identify common genetic risk factors for major depression generalized anxiety disorder panic disorder agoraphobia social phobia and neuroticism (N) in a sample of 9270 adult subjects from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders One member from each twin pair for whom DNA was available was selected as a case or control based on scoring at the extremes of the genetic factor extracted from the analysis The resulting sample of 589 cases and 539 controls was entered into a two-stage association study in which candidate loci were screened in stage 1 the positive results of which were tested for replication in stage 2 Several of the six single-nucleotide polymorphisms tested in the GAD1 region demonstrated significant association in both stages and a combined analysis in all 1128 subjects indicated that they formed a common high-risk haplotype that was significantly over-represented in cases (P=0003) with effect size OR=123 Out of 14 GAD2 markers screened in stage 1 only one met the threshold criteria for follow-up in stage 2 This marker plus three others that formed significant haplotype combinations in stage 1 did not replicate their association with the phenotype in stage 2 Subject to confirmation in an independent sample our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression
Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter system have been noted in subjects with mood and anxiety disorders
27
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
FUT2 amp IGA
IgA Snps
Tendency toward food allergies especially with leaky gut syndrome
FUT2 has possible contribution to imbalances in the gut microbiome and B12
28
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
MTHFR
Methylation pathway issues
Sometimes the of polymorphisms will give indication of the ldquofragilityrdquo of the pathway and ease of expression
29
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Mitochondrial Complex 1
NADH-ubiquinone oxidoreductase - GSSG will block the entry of the electron donors into the electron transport chain
30
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
SNPs Indicate Probable Issue in the Following Areas
Neurotransmittersbull COMTbull GADbull Others MAO
Leaky Gut Syndromebull IgAbull SHMTbull FUT2
Aldehyde Metabolismbull NAT
Methylationbull MTHFRbull MTRR
Mitochondrial Dysfunctionbull SODbull PON1bull NOSbull NDUFS
Hallucinationsmood issues based on Neurotransmitter balance
Yeast will produce Acetyl Aldehyde-Stool test
Oxidative Stress will block pathway preventing ATP production
Will Cause Immune Upregulation Immune Dysregulation Neural excitation AutoimmmuneDisease Dysautonomia
31
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
NEUROTRANSMITTER BALANCE
Urinary Neurotransmitter Testing
32
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Common Argument Concerning The Use of Urinary Neurotransmitter (NT) Assessments
Usual Statements I Hear
There is no peer reviewed research supporting their use
The measurements do not represent CNS
Therersquos no evidence of their efficacy in the diagnosis and treatment of various disorders
My Usual Responses
Urinary (or serum) NTrsquos are both CNS and PNS
Urinary NTrsquos are used as BIOMARKERS to more accurately target treatment decisions when combined with the patientrsquos history and other clinical data
BTWhellipWhat are you using to measure NT levels (I wait in silence and listen to the crickets while the questioner finally realizes that he does not use any form of assessment and is essentially guessing)
33
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
34
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
BIOMARKERSThe Key Concept
Townsend Letter 2009
35
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Our Patienthellip
InhibitoryExcitatory Balance Visually compare the rough levels of
inhibitory NTrsquos (Serotonin GABA Taurine Glycine) with the excitatory NTrsquos (Glutamate Histamine PEA Dopamine Norepi Epi)
The excitatory NTrsquos ldquooutweighrdquo the inhibitory NTrsquos
The rdquoNet Resultrdquo is an excited nervous system
Hallucinations Always from over excitation Classically high dopamine causes
hallucinations (but not always) Glutamate Histamine PEA
Dopamine Norepi Epi can all cause ldquoexcitotoxicityrdquo or perhaps itrsquos the combination
Sometimes you can eradicate hallucinations by raising inhibitory NTrsquos in combination with lowering Glutamate Histamine etc abrogating the need for anti-psychotic meds
Adrenal Fatigue
36
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
WHO IS UPREGULATING THE NERVOUS SYSTEM
Root Cause Analysis
37
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Root CausehellipThink NEI
Each of these systems have the receptors for the biomarkers of the others As such they are in constant ldquoconversationrdquo What happens in one system affects the others
38
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Leaky Gut Syndrome
Net ResulthellipINFLAMMATION
39
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Microbial Involvement
Consider Lyme Disease Co-Infections Strep Viruses parasites
40
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Labs and Dx
Lab Child was extensively
tested and found to have antibodies to Lyme Yeast and HHV6
Numerous food allergies by IgG testing
Concentrations were in Gluten Dairy and Yeast areas
41
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Western Blot for Lyme testingMDL Labs
Lyme Western Blot Negative
But is it really negative
42
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Donrsquot Believe the ComputerIgG
Reports 1 when I see 7 bands
With Human Eyes the WB meets CDC criteria
Reports zero when I see 3 bands
43
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Lyme Cytokines
Note the Baseline First
If baseline is negative then the upregulated stimulated cytokines confirm exposure to Lyme
If baseline is high upregulation of the stimulated cytokines may be false positive
44
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Considerations
Leaky Gut Syndrome can and does lead to immune upregulationdysregulation This is evidenced by the numerous food allergies and the patientrsquos GI symptoms Can this cause the increase in catecholamines and hallucinations
Lyme and HHV6 attack the neural cells Can this cause the increase in catecholamines and hallucinations
Yeast overgrowth causes increased levels of acetylaldehyde Combined with the NAT2 snps Can this cause the increase in catecholamines and hallucinations
Answer Yes to all of the above
45
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
TreatmentStep 1 GI RepairNT Balance
Gluten Free diet
Casein Free diet
Soy Free diet
Demulcent herbs to recreate the mucus layer
Phospholipids to support cellular repair
Digestive enzymes to assure full breakdown of foods and prevent creation of antigens
DAO enzyme to help break down histamine
Probiotics (soil based w S Boulardii)
Phenylated GABA and 5HTP to counterbalance excitation
L Theanine to block glutamate receptors
Covered the basics
At the time oxalates were not on the radar
46
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
TreatmentStep 2 Kill the Bugs
Child was co treated by myself and an integrative pediatrician
GI Repair program was conducted for a period of 3 months
Thereafter we went after the bugs There was some disagreement as to the form of treatment (whether to insert a PICC line and use rotating antibiotics or use other available non-pharmaceutical options)
The parents were given full information pros cons etc by the pediatrician and myself
The parents chose the latter
47
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
TreatmentStep 3 Retest
Two months after treatment started testing was done again at the same lab
All results were negative
All symptoms were gone
48
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
She is now 12Progressing through puberty without issues
Maintains her diet and lives a normal ldquotweenrdquo lifestyle
Prospect A life on antipsychotic meds
Reality Hallucinations were a ldquodownstreamrdquo effect of neural excitation secondary to infections
Result A life saved
49
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
What Have We Learned
NT Imbalance can cause all manner of maladies
NT imbalance can come from numerous root causes singularly or in combination
You MUST look at each personrsquos condition INDIVIDUALLY
All parameters of Bio-Individualized Medicine MUST be considered
No singe parameter should be treated in a vacuum The person MUST be treated as a whole
Your Health Care Provider must act like ahellip
A Detective
50
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
How To Get Your Own Brainwall PosterDesign Your Victory
The Art Work of Jesse Armine
wwwdesignyourvictorycom
51
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Lyme Disease Panel(USA only- email us if you are outside the USA for more info)
CBIM Panel (MDL Labs) Our Panel Includes
Anaplasma phagocytophilum IgGIgM by IFA Babesia microti by Real-Time PCR Babesia microti IgGIgM by ELISA Babesia WA1 by Real-Time PCR Bartonella henselae IgGIgM by ELISA Bartonella henselae by Real-Time PCR Borellia afzelii by Real-Time PCR Borellia garinii by Real-Time PCR Borellia lonestari by Real-Time PCR Lyme disease (B burgdorferi) DNA by Real-Time PCR Lyme Disease C6 peptide by ELISA Ehrlichia chaffeensis (HME) and Anaplasma phagocytophilum by Real Time PCR Rickettsia rickettsii (RMSF) by Real-Time PCR Lyme Disease Western Blot IGMIGG Candida albicans by Real Time PCR Toxoplasma gondii by Real Time PCR Parvovirus by Real Time PCR
A Western Blot that you can see with your own eyes
An Interpretive consultation with an experienced unbiased health care provider
Your Cost $79900
The first 25 people who take advantage of this offer will receive a 15 discount (you pay $67915)
IgeneX Initial Lyme Panel
Western Blot IgG Western Blot IgM Lyme PCR-Serum and Lyme PCR-Whole Blood
Master Co-Infection Panel B microti IgG amp IgM B duncani IgG amp IgM Babesia
FISH HME IgG amp IgM HGE IgG amp IgMBartonella IgG amp IgM Rickettsia ricketsiityphi IgG Antibody
No Interpretive Consultation
Your Cost $123000
The Interpretative Consultation includes a brief history of your condition a review of the testing an opinion as to the results of the testing and information on how to obtain treatment Please note The Health Care Provider will not recommend or prescribe treatment in this consultation
52
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Neurotransmitter Interpretation CBIM NT Panel Includes Neurotransmitters tested
Epinephrine
Norepinephrine
Dopamine
Serotonin
Glycine
GABA
Glutamate
PEA
Histamine
An interpretative session with Shawn Bean or Dr Jess Armine that includes an initial treatment plan targeted for balancing NTrsquos
Your Cost $441
The first 25 clients that schedule for this offer will receive a 15 discount (you pay $37485)
53
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
How To Contact Us ampTake Advantage of CBIMrsquos Panels
Dr Armine and Shawn Bean can be obtained inside and outside the USA by
E-mail bioindividualmedgmailcom
Fill in contact form at wwwmethylationsupportcom
Phone 610 449 9716
To get more information about the Lyme Disease Interpretation Panel and the Neurotransmitter Interpretation Panel
Contact the Patient Coordinator at
E-mail bioindividualmedgmailcom
Phone 610 449 9716
copy Dr Jess Armine 2015
54
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015
Evidenced Based References
bull NEI httpswwwneuroreliefcomindexphpp=cmsampcid=108amppid=85amptype=1
bull Brain Basics httpwwwnimhnihgovhealtheducational-resourcesbrain-basicsbrain-basicsshtml
bull The Brain from Top to Bottom httpthebrainmcgillcaflashii_01i_01_mi_01_m_anai_01_m_anahtml
bull Neurotransmitters An Introduction httpmybrainnotescomserotonin-dopamine-epinephrinehtml
bull Epigenetics of depression Lolak S Suwannarat P Lipsky RH Prog Mol Biol Transl Sci 2014128103-37 doi 101016B978-0-12-800977-200005-X PMID 25410543
55
copy Dr Jess Armine 2015