European Biotechnology News Special 12/2011 - Biotech Clusters & Markets
The Biotechnology Center of Excellence Bringing Biotech from the Bench to the K-12 Classroom
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Transcript of The Biotechnology Center of Excellence Bringing Biotech from the Bench to the K-12 Classroom
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The Biotechnology Center of ExcellenceBringing Biotech from the Bench to the K-12 Classroom
Event: Regenerative Medicine WebinarDate: May 22, 2014, 4pm & 7pm CSTLocation: Lindblom Math & Science Academy
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Webinar Objectives As a Result of Webinar Participation, You
Will:1.Realize the Need for Regenerative Medicine
Practices and Procedures
2. Identify the Tools and Technologies of Regenerative Medicine
3.Understand the Challenges, Promise and Potential of Regenerative Medicine
4. Identify the Potential Benefits of Regenerative Medicine to America’s Costly Health Care System
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“Body Builders”: The Emerging Science of Regenerative
Medicine
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The Beginning………
Charles Vacanti & Robert Langer (1997)
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Characterizing Regenerative Medicine
1. Regenerative medicine is a broad definition for innovative medical therapies that will enable the body to repair, replace, restore and regenerate damaged or diseased cells, tissues and organs. (Mayo Clinic)
2. Science Merges with Technology to Achieve Self-Healing• Regenerative medicine uses procedures to repair or replace damaged or diseased
tissues and organs—Many traditional therapies only treat symptoms.
3. Tools and Procedures (Biofabrication or Additive Manufacturing) of Regenerative Medicine
• Tissue Engineering: Tissue Repair/Replacement and Lab Grown Organs• Technologies Stem cells Natural and Synthetic Scaffolds 3-D Printing and Chip Technologies
4. Highly Interdisciplinary Field where Biology and Chemistry meet:• Engineering• Material Science
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Areas of Regenerative Medicine
1. Artificial Organs: Medical Devices
(Lab Grown Bladder)
2.Tissue Engineering & Biomaterials
Scaffolds
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Areas of Regenerative Medicine
3. Cellular Therapies• Use of Stem Cells (From Patient)• Development of Regenerative
Medicine Treatments.• Enhance Regeneration of Tissues
and Organs.
4. Clinical Trials• Many Currently in Progress.• NIH and Private Organizations.
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Regenerative Medicine Procedures/Protocols
Engineer Scaffolds
•
HydrogelSpaghetti Highways
Ear Scaffold
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Regenerative Medicine Procedures/Protocol
Seed Scaffold With Stem Cells
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Regenerative Medicine Procedures/Protocol
• Incubate Seeded Scaffold in Bioreactor
• Transplant into An Animal Model
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Regenerative Medicine And PRP Therapy
• PRP: Platelet Rich Plasma Therapy• Concentrate Platelets from Patients Blood
Sample• Platelets Contain Cytokines and Growth
Factors• PRP Accelerates Healing and Reduces
Pain• Bill Nye “The Science Guy” and PRP
Therapy
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Regenerative Medicine Pioneer
Wake Forest Institute for Regenerative Medicine (WFIRM)
Dr. Anthony Atala
•First to Engineer/Transplant Lab-Grown Organ into a Human
•Transplant was Successful•Currently Developing Organ on a Chip Program
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Regenerative Medicine Pioneer
Dr. Paolo Macchiarini (Karolinska Institute)
•2008: Implanted World’s First Donor Trachea•Recipient: Claudio Castillo•Survived Procedure—Now Has Normal Respiratory Function
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Regenerative Medicine PioneerMcGowan Institute of Regenerative Medicine (University of Pittsburg)
Dr. Stephen Badylak•Removed Cells from Pig Bladder Extra Cellular Matrix (ECM)•Dried: Forms “Pixie-Dust”•Re-grows Severed Digits and New Muscle Tissue
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Regenerative Medicine Pioneer
AFIRM: Armed Forces Institute Of Regenerative Medicine.
•Treatment Procedures for Severely Wounded Soldiers•Funded and Managed by US Army•Partnership with Wake Forest Institute for Regenerative Medicine
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Regenerative Medicine Innovator
Dr. Geraldine Hamilton (Wyss Institute)
Organ on a Chip Technology(Drug Testing Tool)
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Regenerative Medicine Innovator
Jordan Miller (Rice University)• Uses 3-D Print Technology• Engineers Blood Vessels Using Sugar
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Regenerative Medicine Innovator
Ramille N. Shah, PhD (Northwestern University)
• Leader in Field of 3D-Printable Materials
• Engineers new 3D-Inks
• Creates Porous Scaffolds
• Technique: Additive Manufacturing
(Nanofiber Scaffold For
Cartilage Regeneration)
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Regenerative Medicine Challenges1. Design of Biomaterials that Function in
the Body
2. Getting Enough Cells and Cell Types for Engineering Tissues and Organs
3. Vascularity: Engineering Blood Vessels that Supply Nutrients, Oxygen and Signals to Bioengineered Tissues and Organs
4. Cost of Tissue and Organ Development Procedures
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Organ Decellularization Approach
Dr. Harald Ott
http://www.youtube.com/watch?v=5wfdhB_VyJw
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Challenge To Regenerative Medicine
Bioengineering of Organs
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Potential of Regenerative Medicine
Chip Technology
• Reduces Need for Animal Testing
• 3-D Printed Organs on Chips Used to Test Vaccines
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3-D Elastic Membrane Fits Heart’s Epicardium
3-D Printer Creates Heart Membrane
Promise of Regenerative Medicine
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The Business of Regenerative Medicine
Organovo3-D Bioprinting CompanyStarted A Collaboration with NIH (January 2014)Goal: Bioprinting of 3D Living Tissues • Eliminate Challenges to New Therapy
Development• Animal Models: Poor Predictors of Drug Efficacy
and Toxicity
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The Business of Regenerative Medicine
TengionA Biotechnology Company Company Platform for Engineering
Tissues/Organs Organ Regeneration Processo Doctors send Tissue Sample from Diseased or
Failing Organ to Tengiono Tengion Selects and Multiplies Healthy Cellso Place Cells on an Organ-Shaped Scaffoldo Result: A Neo-Organ for Transplant
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Futuristic!
Stem Cells + Organ Scaffold + 3D Printer
= Libraries of Replacement Organs?
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Regenerative Medicine Summary
• Regenerative Medicine Approacheso Use of Patients Stem Cellso 3-D Bioprinting of Tissues and Organso Organ Decellularizationo PRP: Plasma Rich Platelet TherapyHuman TreatmentVeterinary Medicine Therapy
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Regenerative Medicine And Healthcare
• New Era in Medicine: Move from Treatment to Cures (Self-Healing)
• Eliminate Organ Transplant Shortage
• Reduce Health Care Costs
• Now A Medical and Commercial RealityOver 60, 000 Stem Cell Transplants Worldwide2012: Cell Therapies Generated More Than
$900 Million
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