Bone loss is primarily due to Bone Remodeling Process, Unchangeable risk factors such as gender, body size and etc, and changeable risk factors such as coffee consumption and lack of exercises.

What is Bone Remodeling? Basically there are 2 types of bone cells. Osteoclast which destroys worn out cells (Resorption) so that Osteoblast can regenerate new bone cells. This is how the bone remodeling process works.

However, after the age of 30, things changed. The number of Osteoclasts increases and they tend to work more aggressively destroying old and worn out cells. On the other hand, Osteoblasts become inactive or rather they work slower. Their efficiency of making new bone cells decreases. This means that they cannot replenish the bone faster than the Osteoclasts destroying the bone cells.

Therefore, after the age of 30, bone tends to become porous which leads to Osteopenia and even Osteoporosis. Coupled with some unchangeable and changeable risk factors, it makes bone degradation becomes even faster.

THEORY BEHIND…

Bone Remodeling

Wear & Tear

Osteoclast

Osteoblast

Healthy Bone

One cycle of bone remodeling process: 4 months

Bone Loss Increase After the Age of 30

Wear & Tear

Osteoclast

Osteoblast

Osteoporosis

↑Bone Fracture Risk

Unchangeable Risk Factors

Female

Aging

Caucasian & Asian

Tiny Body SizeFamily History

Changeable Risk Factors

WHY IS CALCIUM THE MOST IMPORTANT NUTRIENT?

In human body, 99% of CALCIUM is stored in bone and teeth

CaCa

CaCa

CaCa Ca

Ca

Another 1% is stored in blood

So, the 99% or the 1% is important?

Answer is

SO WHICH IS MORE IMPORTANT, BONE 99% OR CELL 1%?

BOTH!99% of CALCIUM forms human skeletal system, which without it we can’t even

stand, sit or move. Don’t forget, blood cells are made from BONE too!

Another 1%, though it’s minute, the roles it plays are MAGNIFICIENT! Because this 1% helps in:

Activate Enzyme SystemActiveness and Production of CellMaintain heartbeat and muscle contractionMaintain Cell Membrane Permeability and Stability

Regulating Nervous System (Signal Transduction)Normalize Immune SystemPromote Hormone SecretionPromote Blood Clotting

WHY IS CALCIUM THE MOST IMPORTANT NUTRIENT?

However, it has to be balanced. Because -

According to WHO’s statistic, 106 in 135 recorded human common diseases are

related to imbalance calcium metabolism.

WHY IS CALCIUM THE MOST IMPORTANT NUTRIENT?

In the case of

CALCLIUMdeficiency

Mild Moderate Severe

Insomnia Osteoporosis Children growth retardation

Muscle cramps Chronic backache Rickets

Loss of appetite Hunchback Osteomalacia

Irritability Arrhythmia Colon cancer

Tension Hormone imbalance Difficulty in breathing

Hypotension Decreased liver function

Mental disorder

Hypertension Drop of teeth Bone deformation

Brain sluggish Height reduction Heart failure

Decrease resistance “O” shape leg Bone fracture

Congestion Aching of waist & leg

Allergy Cardiac dysfunction

Lack of energy Pulse disturbance

Extremities numbness Joint pain

The Deficiency of Calcium

OSTEOPOROSIS

MUSCULAR ATROPHY

ARTHRITIS

They are interconnected and are due to Calcium Deficiency!

PROBLEMS OF TOO MUCH CALCIUM ?

In the case of too much CALCIUM where it causes HYPERCALCEMIA

◎Diabetes Mellitus ◎Alzheimer’s disease◎Hypertension ◎Arteriosclerosis◎Stroke ◎Extremities numbness

◎Heart numbness ◎Calcification ◎Kidney stone ◎Cataract ◎Cell degeneration & death◎Deterioration of disease

Consuming Calcium & Vitamin D doesn't help in preventing Bone Fracture

United StatesNew Zealand

Most of the Americans and New Zealanders drink milk, take Calcium supplements everyday and have exposure to sunshine. Why are they having the highest pelvic fracture rate?

DO THESE QUESTIONS EVER CROSS YOUR MIND?

1.Why is there Calcium deficiency even when you take Calcium?

2.Why do people who regularly consume Calcium still have gaps in their Dexa Scan, a Bone Mineral Density test?

3.Why are people still suffering from Osteoporosis even when they consume Calcium?

The Passage of Calcium Absorption

Calcium in Food

50% Stomach

Small Intestine (SI)

Calcium in Bone

細胞 Cell

1%

99%

20%

Par

ath

yroi

d H

orm

one

Diagram: Digestive system

Blood

From food, Ca goes through digestive tract. 50% of Ca destroyed by stomach acid, remaining 50% to small intestine. From SI, 20% of Ca goes into blood. 1% of it stored in blood. 99% to bone cells. For this 99% to go into bone, CaM is needed.

Calmodulin (CaM)

CELL

The Key Concept for Calcium Absorption into Cell

GlucoseExtracellular Intracellular

Insulin

細胞内

Calcium

Calmodulin (CaM)

細胞外Extracellular Intracellular

What is Calmodulin (CaM)?

Calmodulin -- Calcium Modulated ProteinThere are more than 1.8 million papers and thesis on Calmodulin

http://www.sciencedirect.com/science?_ob=ArticleListURL&_method=list&_ArticleListID=960033643&_sort=r&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4714340e36664b88c4cd52470b60699f

Calmodulin

Calcium Binding Protein

CaCa

CaCa

One Calmodulin has four binding sites. In other words, each Calmodulin combines with 4 Calcium ions and brings them into cells one short.

What is Calmodulin?

CaM

se

cre

tion

100%

50%

5歲 10歲20歲 30歲 40歲50歲 60歲

70歲80歲

Cerebellum Cell

Digestive Cell

Reproductive Cell

Age

CaM secretion reduced after 30 years old which leads to degradation of the functions of different

organs.

What is Calmodulin?

Calcium can be found from a variety of food, eg milk, soy bean, vegetables and etc.As CaM is a natural protein that is being synthesized from human body, we cannot get it from food.

20 30 40 50 60 70 80105

Age

Fortunately there is Professor Wang Kai-Wah, who discovered CaM in 1972 while she was doing cancer researches. Since then, researches as well as clinical trials on CaM was done on mice, monkeys and cancer patients by her.

We cannot get CaM from food but luckily we have Professor Wang Kai-Wah who made it into edible health food.

CaM is produced by single cell culture through Biotechnology. It is formed by 148 amino acids, including both Essential and Non-essential. This formula is not enough as 50% of any food that goes through digestive tract will be destroyed by stomach acid. Therefore, Lecithin is used to cover the combination, so that Ca2+ - CaM complex can be protected from destruction at stomach and reaches cell where it is then be absorbed fully.

Specialize in immunology, cytology, bioengineering & oncology research

Professor Wang Kai-Wah

1954 - Graduated from Beijing Medical University

1958 - Participated in the study of the insulin synthesis1972 - Involved in tumor-associated antigen and skin test for cancer and discovered

Calmodulin

1982 - Professor at the School of Medicine, Xiamen University, and as the chairperson of Xiamen Cancer Research Centre

1990 - Established the Bionike Laboratory in America, which specialize in the research and development of bioengineering technologies as well as the production of medical supplies.

Worldwide well-known Bioengineering Professor

Recipient of 9 state Technological Invention Awards (China)

FIRST & ONLY Professor who Successfully turns CaM into product &

undergo 20 years of clinical trials

+ Cell

+_

+++

+

+

+

_ __

_

_

_

_

World’s Leading Bioengineering Technology

CaCa

CaCa

CaM

Single cell culture formed by 148 amino acids chelated with 4 Ca2+

Uniqueness 1

_ ++

_

Essential Amino Acid Non-essential Amino Acid

Essential Amino Acids are amino acids that cannot be produced from body and ought to get from food.

Non-essential Amino Acids are amino acids that can be produced from human body.

CaM contains both Essential and Non-essential Amino Acids.

Add up all the numbers indicated after each amino acid and you shall get 148. CaM is made up of 148 amino acids.

+ Cell

+_

+++

+

+

+

_ __

_

_

_

_

World’s Leading Bioengineering Technology

CaCa

CaCa

CaM

Covered by lecithin prevent stomach acid destruction reach small intestine safely electrogenically more than 90% direct absorption

_ ++

_

Uniqueness 2

5 Main Functions of CAM:

1. Bi-directional regulation of Ca2+ concentration

2. Coordination of the nervous system and endocrine system

3. Energy starter and activation of enzyme system

4. Promote the regeneration of cells

5. Regulate immune function

0.69650.6678

1. CaM = Bi-directional regulation of Ca2+ concentration (Calcium replacement in the case of Calcium Deficiency)

DEXA scan shows Bone Mineral Density increases. Some gaps were filled after 4 months consumption of CAM.

1.527 1.307

DEXA Scan shows calcification reduces in which excess calcified calcium is being removed, which leads to decreased Bone Mineral Density (BMD closer to ideal 0.995) after 4 months consumption of CAM.

1. CaM = Bi-directional regulation of Ca2+ concentration (removes excess calcified Calcium in the case of Calcification)

Osteoporosis & bone spur BMD ↑11% & bone spur become smaller

1. CaM = Bi-directional regulation of Ca2+ concentration (removes excess Calcium growth in the case of Bone Spur)

Before use of CAM

After use of CAM

This Taiwanese old lady has 90o hunchback that causes stomach bleeds due to compression. The effort of inserting endoscope was finally done after 21 attemps.

CaM does not magically turn her bone to straight. But rather, CaM helps in replenishing Ca into bone that makes her bone becomes stronger. As bone becomes stronger, it has the strength to support body weight and she can stand up straight. Or else, weak bones tend to be crooked and cause hunchback and arthritis.

Mdm Lin Age: 70+

1. CaM = Bi-directional regulation of Ca2+ concentration (Calcium replacement in the case of Calcium Deficiency)

2. Coordination of the nervous system and endocrine system

CaM helps in regulating nervous system where spine and leg soreness and pain experienced due to severe loss of Calcium can be relieved.

Signal transduction in neurons requires Calcium. Some nervous system diseases such as Alzheimer’s and Parkinson’s Disease are due to insufficient Calcium in neurons which leads to improper signal transduction. Supplementing Calmodulin to ensure that Calcium is being absorbed into cell helps in activating signal transduction which in turn, alleviate Alzheimer’s and Parkinson’s Disease symptoms.

As CaM helps in regulating endocrine system, diseases caused by hormone imbalance such as diabetes, obesity and even pigmentation and black spots especially during menopause could also be alleviated.

2. Coordination of the nervous system and endocrine system

Before use of CAM After use of CAM

This lady from Sarawak, Malaysia suffered from facial stroke for 38 years.

CaM helps in regulating nervous system. Signal transduction in neurons was well regulated after consumption of CAM for almost a year that loosen up of facial muscle as shown above. Her limbs and legs joint pain have been reduced. Her speech became clearer too.

Mdm Agnes Siah Age : 70

3. CAM = Energy starter and activation of enzyme system

CaM helps in activating mitochondria and enhancing ATP generation. Besides, CaM also enhances S.O.D enzyme to remove free radicals. Act as an energy starter, CaM enhances vitality.

As CaM activates a series of biochemical reactions in body by activating enzyme system. This improves gastrointestinal tract (GIT) function and increase cell metabolic rate.

E.CaM.Ca2+

A + B C

Biochemical Reaction

CaM . Ca2+

E = Enzyme

CELL

4. Promote the regeneration of cells

Cell division (phase M) – the important regulator - CaMK-II

The CaMK-II protein level wasunchanged during the cell cycle. When the cells were synchronized, the autonomous activity was increased only in M.

These results indicate that the physiologically relevant portion of CaMK-II is activated only in M, and that the net activation of CaMK-II is required in mitosis.

Activation of CaM during phase M in cell division

These data suggest that calmodulin regulates mitotic transitions.

CELLULITIS

RAPID WOUND HEALING in 4 months time

Mdm Tsie from Taiwan suffered from Cellulitis due to a wound on her

foot. She was being transferred from

hospital to hospital but it does not seem to work for her. After consuming CAM, wound started to

heal. CaM activates CaM K-II which promotes cell

replication.

Before use

After use

The adult bone marrow stem cells

Inside the adult bone marrow, there are two types of stem cells, Hematopoietic Stem Cell (HSC) & Mesenchymal Stem Cells (MSC).

HSC inside the bone marrow can differentiate into red blood cells, white blood cells and platelets to maintain normal function of blood. Besides, it can differentiate into lymphocytes and macrophages to regulate immune function.

MSC was mainly found in bone marrow, can be found in cord blood, peripheral blood and adipose tissue too. MSC can differentiate into various type of cells, including osteoblasts, chondrocytes, fat cells, muscle cells, etc. In addition, MSC can support the hematopoetic process of HSC.

Calmodulin-dependent Protein Kinase IV regulates Hematopoetic Stem Cell Maintenance

Mesenchymal stem cells (MSC)Mesenchymal stem cells (MSC)Mesenchymal stem cells had been revealed in the US official journal – Science on 2nd April 1999.

Multilineage Potential of Adult Human Mesenchymal Stem Cells

Science 284, 143 (1999)

Mesenchymal Stem Cell (MSC)Bone marrow will be stimulated to release MSC when it receives the signals from the injured tissues. MSC will mobilize into circulation to the injured tissues and undergo differentiation for tissue regeneration and healing in order to maintain the constant number of body cells.

MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation

The application of fluid flow also induced the phosphorylation of extracellular signal-regulated kinase-1and -2 as well as the activation of the calcium-sensitive protein phosphatase calcineurin in mesenchymal stem cells.

Am J Physiol Cell Physiol 290: C776–C784, 2006.

Ca2+ . CaM complex and regeneration mechanism

CaM + Ca2+

CaM K-II

Mitosis(Cell Replication/

Cell Division)

CaM K-IV

activates

promotes

Hematopoietic Stem Cell

Synthesize Blood Cells

activates

activates

promotes

Calcineurin in Mesenchymal Stem Cells

activates

Injured Part

Wound Healing Process

to

Carry out

To summarize:

Without CaM, all these biochemical reactions in human body cannot be carried out.

CaM + Ca2+

Analogy:

Ca2+ = Lock CaM = Key

A key is needed to lock or unlock a lock. The key is like a regulator. Likewise, CaM is the regulator for Ca2+.

Without CaM (the key), many of the biochemical reactions in the human body cannot be carried out. Moreover, it is to no avail if you have enough Ca2+ (Lock) but no CaM (Key) to activate these series of biochemical reactions in the body.

Frame of Life

5. Regulate immune function

CaM regulate immune function by activating macrophages . Activated macrophages will engulf and destroy substances that are harmful to the body, such as toxins and even tumour cells.

In addition, CaM also prevents tumour cells from obtaining nutrients. Cancer patients often feel weak. Therefore, CAM is essential for nutrients replacement especially for cancer patients after they have done chemotherapy or radiotherapy.

CaM activates macrophages and helps in preventing cancer and bacteria invasion, enhancing immune system and eliminating age spots and lipomas.

Mr. Khor (on the left) from Kuala Lumpur, Malaysia suffered from Prostate Cancer in 2007. He was recommended CAM by his doctor (on the right). After consuming CAM, the PSA (Prostate-specific Antigen) dropped from 130 to 0.4. He is still enjoying good health until now.

Age : 73Mr. Khor

CAM TM

ma-CAM TM

CAM TM

Basically contains Calmodulin, Skimmed Milk, Lecithin, American Ginseng and Soybean Extract.

Please note that it is American Ginseng but not Ginseng. (Ginseng is reported to be heaty and breast and ovarian cancer-causing). Soybean Extract is without the outer layer that contains Purine. Therefore, it does not affect Uric Acid, rather CaM regulates nervous system which reduces ache and endocrine system which promotes balanced hormones.

ma-CAM TM

Basically contains Calmodulin, Millet, Lecithin, American Ginseng and Soybean Extract. The Skimmed Milk in CAM is replaced with millet.

The amount of Calmodulin in ma-CAM is lesser but the binding affinity has been improved by 30%. Therefore, it gives the same effect as CAM.

ma-CAM is to cater those with lactose intolerance or with chronic diseases for eg, Hypertension, Diabetes, High Cholesterol, Uric Acid or Heart Diseases. It is recommended for the elderly and vegetarians.

What are the differences between CaM and Fosamax

since both of them are for Calcium replacement?

Question:

References:1. http://www.healthcentral.com/osteoporosis/c/73/8029/boniva-oral/2. http://www.coreynahman.com/osteoporosis_pagets.html

Comparison Fosamax Actonel Boniva CAM and ma-CAM

Category Drug Drug Drug Health Food

Side effects Affects stomach, liver and kidney. Jaw necrosis. Cancer. It’s food. No side effects.

Dosage Once a week orally. Once a month orally.Intravenous once in 3 months.

Can be taken daily because it’s a food that causes no side effects.

Do’s and Don’ts Consume in a sitting or standing posture. Cannot lie down within 30 mins after consumption.

Consume in a sitting or standing posture. Cannot lie down within 1 hr after consumption.

No restrictions whatsoever.

Effectiveness Only prevent Osteoclasts from destroying worn out cells (Resorption). Do not activate Osteoblasts to regenerate new bone cells. Even for Fosamax, it gives only 9% improvement in 3 years time.

Normalize Bone Remodeling Process. Activate Osteoblasts to regenerate new bone cells. Proven and testified by thousands of CaM consumers via Dexa Scan.

Balanced Nutrient＋

Regulator

Say NO to OSTEOPOROSIS

~EFFECTIVELY IMPROVE~ OSTEOPOROSIS, ARTHRITIS & MANY OTHER

ISSUES AS DISCUSSED EARLIER.

Reminder:

It is insufficient to consume supplement

alone without the REGULATOR or

TRANSPORTER of that nutrient. A lock needs a key to be

locked or unlocked.

Living Tips

1. Be careful when you walk 2. Carrying heavy things is not recommended

4. Exercise regularly

3. Hiking is not recommended;Be careful when going up & down

the staircase

＋

It’s a bit long but worth reading.

Best Wishes and Thank You.