Your Presenter: Luana DeAngelisYour Presenter: Luana DeAngelis

Director, Founder, Patient Navigator:

•2x Breast cancer survivor•Generational background in

Natural Health•Founder/Executive Director:

You Can Thrive! Foundation•Often called as an expert by large

media outlets•Passionate about holistic methods

Disclosure:I will discuss investigational use in my presentation.

I have no conflicts of interest to disclose:For full disclosure You Can Thrive! receives a product grant from Young Living Oils since 2008. I am also an independent distributor of essential oils.

Founder/Director of: You Can Thrive!

The Benefits and Considerations of Using Therapeutic

Essential Oils in Cancer Care

Disclosure:Statements made on this presentation are generally pertaining to Young Living Essential Oils. Statements and data have not been evaluated by the FDA. These products and information are not intended to diagnose, treat, cure or prevent any disease. Anyone suffering from disease or injury should consult with a physician. If you are currently on medication, please DO NOT STOP.

These compounds are meant to support your health only.

The Benefits and Considerations of Using Therapeutic

Essential Oils in Cancer Care

SummaryThis presentation will provide an overview of therapeutic grade essential oils and their efficacy to both detoxify and promote health in the body as a whole.

• History• How oils are produced• What makes oils effective• Basic science• Promising data • Additional uses for the oils • Q&A at the end of the presentation.

• WWII: Dr. Jean Valet used essentials oils to treat soldiers

• 1950’s: Marguerite Maury was first to give prescribed combinations

• Late 70’s early 80’s: essentials oils became major part of alternative holistic health systems

“Aromatherapy” first coined in 1937 by the French chemist and perfumer Rene Maurice Gattefosse.

Modern Medicine Aromatherapy

• “Life Blood” of the plants they were harvested from.

• Principally composed of classic organic compounds

• Extremely Concentrated: one drop contains 40 million-trillion molecules.

What Are Essential Oils?What Are Essential Oils?

Why are Essential Oils Why are Essential Oils So Effective?So Effective?

Ripple Effect: Takes one molecule to open the right receptor and communicate with the DNA to alter cellular function.

Our bodies know exactly what to do with these oils; the body uses what it needs and rejects the rest.

Limbic System Delivery

• Terpenes: make essential oils unique• More active compounds within essential oils contain

more isoprene unites• Main organic compound categories:

(each group exerts specific actions on human cells) • Phenylpropanoids• Monoterpenes• Sesquiterpenes • Antineoplastic

Organic ConstituentsOrganic Constituents

Therapeutic GradeTherapeutic Grade

•Optimal naturally occurring blend of constituents to maximize desired effect.

•Shelf Life:•Therapeutic Grade= Forever (with exceptions)•Impure Oils= 2 year

•Can turn rancid•Tiny percentage of oils in the world are meant for

medicine.

•Therapeutic Grade: •Careful monitoring process and seed selection.•Grown in areas with low concentrations of pollution •Crops managed by hand and no pesticides or fertilizers

ProductionProduction

Other Terms•Blocking Agent: prevent carcinogens from reaching target

sites by acting as barriers•Suppressing Agents: Suppress proteins expressed by

cancer cells that signal uncontrolled growth

Cancer | Pathways

One means of classifying inhibitors is on the basis of the time in the carcinogenic process at which they exert their inhibitory effects. Some PREVENT the formation of carcinogens.

Cancer | Cellular Stress

Masayasu Jo – Taichiro Nishikawa – Yoshihisa Okada – Kanji Yamaguchi – Hironori Mitsuyoshi – Kohichiroh Yasui – Masahito Minami – Masaki Iwai – Keizo Kagawa – Yoshito Itoh – Toshikazu Yoshikawa

Oxidative stress is closely associated with tumor Angiogenesis of hepatocellular (Liver) carcinoma

ORIGINAL ARTICLE – LIVER, PANCREAS AND BILIARY TRACT

Received 22 December 2009/ Accepted 9 February 2011/ Published Online 31 March 2011

ORAC Designation

Prevention: the cure?

Normal course ofcancer progression

Cancer prevention

.“Monoterpenes in breast cancer chemoprevention”

The multiple antitumorgenic effects of limonene are attainable at a high therapeutic ratio, suggesting that limonene and related monoterpenes may be efficacious in the chemoprevention and chemotherapy of human malignancies”.

Complete Tumor Regression –The complete regression of mammary carcinomas by limonene appears to involve tissue redifferentiation.

Breast Cancer Res Treat 1997 Nov-Dec;46(2-3):191-7 Crowell PL.

Abstract - Pub Med – National Library of Medicine / National Institutes of Health

D-Limonene (Citrus Peel Oil)D-Limonene (Citrus Peel Oil)

TRdonePhase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee.D M Vigushin, G K Poon, A Boddy, J English, G W Halbert, C Pagonis, M Jarman, R C Coombes

Department of Medical Oncology, Charing Cross Hospital, London, UK. PURPOSE: D-Limonene is a natural monoterpene with pronounced chemotherapeutic activity and minimal toxicity in preclinical studies. A phase I clinical trial to assess toxicity, the maximum tolerated dose (MTD) and pharmacokinetics in patients with advanced cancer was followed by a limited phase II evaluation in breast cancer.

D-Limonene + Cancer StudiesD-Limonene + Cancer Studies

One partial response in a breast cancer patient on 8 g/m2 per day was maintained for 11 months; three patients with colorectal carcinoma had prolonged stable disease. There were no responses in the phase II study..

CONCLUSIONS: D-Limonene is well tolerated in cancer patients at doses which may have clinical activity. The favorable toxicity profile supports further clinical evaluation.

Since the reactive ultimate carcinogenic forms of chemical carcinogens are electrophiles, induction of GST activity by anticarcinogenic compounds is believed to be a major mechanism for carcinogen detoxification”. “Glutathione S-transferase (GST) catalyzes the reaction of glutathione with electrophiles to form less toxic conjugates for excretion”

It appears that one way that essential oils work is through more effective detoxification.

Limonene ConsiderationsLimonene Considerations

Clove| The most powerful antioxidant oil~ ORAC value of: 1,078,700 uTE/110G

Eugenol is an essential oil mainly found in the buds and leaves of clove (Syzygium aromaticum (L.)

Eugenol inhibits cell proliferation and induces apoptosis in human MCF-7 breast cancer cells (in vitro).

The biological activities of Eugenol in human breast cancer cells can be correlated to its potential activity as an estrogen receptor (ER) antagonist.

Results of Therapeutic Oils Studied In Results of Therapeutic Oils Studied In Human Cancer Cell LinesHuman Cancer Cell Lines

60 Oils Tested for their anti-cancer activity. Results for oils that inhibit cancer growth in-vitro with low normal cell toxicity

BREAST CANCERConcentration (parts

per million)% Cell

Inhibition

Sandalwood 100 ppm 98.10Myrtle 200 ppm 95.20Tsuga 200 ppm 93.10

Symptom Relief• Neuropathy – Frankincense/Peppermint/ reflexology• Hot Flashes – Peppermint on back on neck• Fatigue – Peppermint – inhaled and on temples• Pain- Peppermint topically• Chemobrain- Peppermint• Depression - Orange• Anxiety an array of oils almost any oil will help anxiety• Nausea- Ginger, peppermint, Fennel inhaled and/or on tongue• Insomnia- valerian, lavender• Courage- Frankincense, Tansy, Rosewood,

Internal & Experimental Use• Certain oils can be used internally as part of a

regimen for maintaining health

• Quality is imperative

• Consult with a professional

EXPERIMENTAL USE: • In some places in the world essential oils are being

diluted and used intravenously

Therapeutic GradeCan Promote health: •Fatigue•Pain•Cellular Oxidation•Hot flashes•Lymphadema•Hormone Imbalance•Anxiety•Nausea

• Non-toxic• Safe in clinical settings• Safe for internal use

Peppermint Oil

Peppermint oil like the ‘Swiss army knife” of oils and can be used with a multitude of symptoms to promote health amidst the side effects that accompany many conventional treatment protocols.

EmotionalEmotional Benefits BenefitsLessen AnxietyReduce Stress Diminish FearEase DepressionIncrease Feelings of HopeEnhance Sense of

Empowerment

Lavender, Valerian, ChamomileLavender, so many othersValerian, Tansy, FrankincenseJasmine, FrankincenseSandalwoodPepper, Sage, Nutmeg

Reduce FatigueMitigate Nausea Alleviate PainImprove SleepModerate Symptoms of NeuropathyEnhance Mental Clarity

Physical BenefitsPhysical BenefitsJuniper, Cypress, ThymePeppermint Peppermint, WintergreenValerian, LavenderPeppermint, Frankincense Geranium, CypressPeppermint, Rosemary, Lemon

Traditional Uses include:

•Rubbing on forehead, temples, and/or back of neck traditionally used for headaches and hot flashes

•Inhaled & Internally nausea, dizziness or simple halitosis

•Apply topically to alleviate pain

•Diffuse, inhale to improve concentration

•Apply over stomach or ingest to promote healthy digestion

•Rub on bottoms of feet and armpits/groin to soothe fever

Folk Uses for PeppermintFolk Uses for Peppermint

New species of frankincense dubbed “sacra” have been found to have a different and more potent form of Boswellic acid compounds..

FrankincenseFrankincense

FrankincenseFrankincensecan provide cancer-specific cell death

Activates genes responsible for suppressed cancer cell growth and elevated cancer cell death

Frankincense & OncogenesFrankincense & Oncogenes

Gene Symbol

Time after frankincense oil exposure(hours)

0 <0.5 0.5-1 1-2 2-3

IL8 26.3 32.6 146.2 693.6 1241.4

CLK1 42.3 56.1 57.9 121.2 203.3

DLG1 48.3 41.2 31.2 71.8 37.2

H2AFX 105.6 103.3 106.6 51.0 96.1

ING4 73.7 63.0 75.3 37.2 43.6

KLF4 89.2 68.8 123.2 326.0 556.9

NEDD9 38.3 34.3 23.8 59.7 56.7

SSTR1 47.4 37.2 28.4 70.3 27.2

CDKN1A 56.3 54.5 95.7 167.4 382.9

DDIT3 346.7 316.0 523.2 735.5 1647.7

HDAC4 64.4 61.7 52.1 68.0 31.5

IL1A 63.4 44.5 72.1 124.5 252.5

IL6 190.5 235.4 337.2 563.8 1326.4

SNF1LK 40.6 38.8 48.9 95.8 286.3

IL8 26.3 32.6 146.2 693.6 1241.4

CLK1 42.3 56.1 57.9 121.2 203.3

DLG1 48.3 41.2 31.2 71.8 37.2

Gro

wth

inh

ibito

ry g

enes

Cell death genes

FrankincenseFrankincense && Pancreatic CancerPancreatic CancerPurpose“Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine model.

Conclusion“All fractions of Frankincense essential oil from Boswellia sacra are capable of suppressing viability and inducing apoptosis of a panel of human pancreatic cancer cell lines.”

BMC Complement Altern Med. 2012 Dec 13;12:253. doi: 10.1186/1472-6882-12-253.

Ni X1, Suhail MM, Yang Q, Cao A, Fung KM, Postier RG, Woolley C, Young G, Zhang J, Lin HK.Author information1Department of General Surgery, Long Hua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Library/IDArea (%)

78 oC 0-2 hr 78 oC 9-10 hr 78 oC 0-12 hr 100 oC 12 hr

trans-beta-caryophyllene 0.02 0.02 0.28 0.62

alpha-humulene 0.03 0.01 0.11 0.17

allo-aromadendrene     0.02 0.06

gamma-muurolene   0.01 0.05 0.10

germacrene D   0.02 0.09

beta-selinene 0.01 0.02 0.21 0.45

alpha-selinene 0.02 0.01 0.12 0.24

gamma-cadinene     0.04 0.07

delta-cadinene   0.01 0.05 0.14

caryophyllene oxide     0.02 0.05

trans-beta-caryophyllene 0.02 0.02 0.28 0.62

Temperature DistillationTemperature DistillationChemical components depend on duration and temperature of distillationChemical components depend on duration and temperature of distillation

Frankincense & Breast CancerFrankincense & Breast CancerPurpose“Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells”

Conclusion“Boswellia sacra essential oil represses signaling pathways and cell cycle regulators that have been proposed as therapeutic targets for breast cancer”

BMC Complement Altern Med. 2011 Dec 15;11:129. doi: 10.1186/1472-6882-11-129.

Suhail MM1, Wu W, Cao A, Mondalek FG, Fung KM, Shih PT, Fang YT, Woolley C, Young G, Lin HK.Author information1Al Afia Medical Complex, Salalah, Sultanate of Oman.

• Essential oils are a beneficial, if not critical component of any holistic approach to caring for, or staying healthy in the face of serious illness.

• Essential oils can be beneficial both physically and emotionally to enhance mental capacity to deal with stress and illness.

• More research is needed in human subjects to determine their use as treatment or adjunct prevention methods for cancer.

Conclusion

Thrive!Now get out there and

Questions?Disclosure:Statements made on this presentation are generally pertaining to Young Living Essential Oils. Statements and data have not been evaluated by the FDA. These products and information are not intended to diagnose, treat, cure or prevent any disease. Anyone suffering from disease or injury should consult with a physician. If you are currently on medication, please DO NOT STOP.

These compounds are meant to support your health only