The Beam

Dear Friends,

First and foremost, I hope everyone had a great spring and summer! The department was tremendously busy with the groundbreaking of the Maryland Proton Treatment Center (MPTC) in April, with over 550 people in attendance, an extremely successful Radiobiology and Physics Review Course, the arrival of Dr. Zeljko Vujaskovic and his team, and the relocation of our faculty and staff in Radiobiology and Finance.

We are honored to announce that the University of Maryland Marlene and Stewart Greenebaum Cancer Center has been ranked #11 among 900 cancer centers nationwide in the U.S. News & World Report's 2012 "Top Hospitals in America" released last month. These rankings are a reflection of your hard work and dedication

Zeljko Vujaskovic, MD, PhD started in early August as the Director of our newly created “Division of Translational Radiation Sciences” (DTRS). Please welcome Dr. Vujaskovic and his team to the Department. In addition to his role with DTRS, he will have a primary clinical focus in our genitourinary and prostate cancer programs. Please see page 24, for more information about Dr. Vujaskovic and DTRS.

It was great seeing so many of you at the summer picnic in June. Thank you all for the last minute adjustment of location, due to the extremely destructive storm the evening before. It was a pleasure seeing you and your families as we enjoyed great food and a swim in the Cascade Lake.

Every 5 years, we like to provide a comprehensive update and we hope you will join us for the next State of the Department address titled, “The Power of Partnerships, Passion and People, A 10 Year Review and a Glimpse into the Future” This presentation will take place on Friday, September 21st at 5:30. Please see more information on page 9.

As we look forward, there is still a lot to do. Dr. Minesh Mehta will be joining us this fall as Medical Director of MPTC. We are recruiting for Dr. Courtney Bui’s replacement at CMRO and we will be recruiting for faculty and staff at Upper Chesapeake. As always, a very special thank you to our faculty and staff for your commitment to our patients and all of your hard work.

Sincerely,

William F. Regine, MD Isadore & Fannie Schneider Foxman Chair and Professor

THE BEAM SEPTEMBER 2012

Department of Radiation Oncology

INSPIRED BY OUR PATIENTS AND DRIVEN BY PASSION:

To be leaders in defining state-of-the-art care to patients and caregivers by way of collaboration

within and beyond the discipline of Radiation Oncol ogy and through our tireless focus on clinical

Service, Research, Education and Community Outreach .

Table of Contents:

Grateful Patients 2

Alumni News 5

In The News 6

Magic Castle 10

Events 11

Residency 15

ASTRO Presentations 20

Department Highlights 23

CMRO 34

Publications 35

Newest Additions 38

Reminders 39

The Department of Radiation Oncology The BEAM

What our patients are saying …

In each edition of the BEAM we like to highlight a few of the comments from our patients and their families that express the sincere gratitude they feel towards our staff, and their overall patient-care experience.

Dear Dr. Regine,

As I sat down and started to think of all the reasons I was thankful for my mom, I

realized that I had never thanked you for my mom. When we started on this journey of

fighting, healing, courage, hope and faith, we never could have imagined the path,

destination or outcome. I remember traveling with mom and Marisa around the country to

try and find the “right” people to join her in her battle. She had to be in the right place, with

the best equipment, and the best people. We met with the best and brightest in the country

and yet I know when we met with you and your amazing staff that she had found her

battleground for the fight of her life. Of course it didn’t hurt that you were Italian, Dr.

Regine.

As mom prepared for her extended stay in Baltimore, I never doubted that she had

chosen her “warriors” well. I never doubted that she would beat this insidious disease that

was trying to steal her amazing voice, her sharp tongue and her very life. When we met

with everyone at all the other facilities, their first suggestions was a horrifying surgery to

remove her tongue and voice box. I would watch as mom would shut-down, unable to bear

hearing that suggestion yet again. Our journey brought us to the University of Maryland

Medical Center. We were met by your amazing Jill R., and she walked us through the

beautiful interior and down the stairs to Radiation Oncology.

We met with your wonderful team and you, and I remember her coming in after you

had examined her and she was smiling and said, “he’s Italian”. I knew then that she had

made her decision– not because of you heritage, of course, but because she was so at

ease, smiling and joking like “normal” mom. She felt at home and confident in her chance to

beat her cancer with all of you. It was a relief to finally have a plan. I am eternally grateful

for you all wrapping her in your arms and protecting and loving her for us. It made

everything much easier on those of us who were not able to be there with her everyday.

You not only help your patients but you help their families too. You help us to have

piece of mind knowing that our loved ones are in the best possible hands. You give us hope

that they will come home to us. You give us hope that even if things are never going to be

the way they were again, at least we will have the chance to create a ‘new normal”. Be

grateful that you are still alive, and figure out what your “new normal’ will be. So thank you

again for my mom. I will be forever grateful and humbled for the gift of time you have given

to us.

Sincerely,

Heather Tierney



Dear Dr. Regine,

We would both like to express our sincere thanks for the level of care that we received from you

and your staff in the Department of Radiation Oncology over the past two months. It is obvious to us

that each person on your team is looking at “whole patient care” in terms of the cure, and that your

treatments are tailored towards that goal.

You have never been too busy to answer questions or take time to explain in detail the process and

procedures.

In particular, we would like to thank the following individuals for their extensive patience and their

attention to our needs:

Martha Francis, CNRP

Martha has been our first contact on several occasions and has never ceased to amaze us with her

thorough explanations of the process, expectations, and all considerations inherent in a radiologic

cure.

Renee Kwok, RN

Renee has been superior in terms of changing bandages and assisting with educating us about the

proper care of the tumor site. Her patience and her bedside manner are the best, and her hands-on

care is superlative.

Dr. Elizabeth Nichols

Dr. Nichols has been thorough in her approach to the treatment plan, and the explanation of that

plan, that she instills complete confidence. We felt thankful that she was on your team.

There are others that have been involved, but you and the above mentioned individuals have truly

been outstanding.

We thank you.

Sincerely,

Patient



Dear Baltimore Washington Staff,

Thank you all so much for the excellent care that you showed to our

Mother, as well as our family during Mom’s radiation therapy. We

will be forever grateful to all of you for your kindness

All of you make coming here fun.

Sincerely,

Family of a patient

Dear Dr. Oh and the entire staff,

The words in this card cannot even come close to explaining how I personally feel for what all

of you have done for me. The true, heartfelt care, and most of all the continued positive outlook

everyone has is absolutely wonderful. You all are forever in my life and I’m so grateful for

everything. All of you are my “silver lining”. Harmful things will not cripple me if I learn from

them, and you all have helped me in ways I just can’t describe.

Sincerely,

Patient

Dear Tate Cancer Center Radiologist Technicians (Machine #2),

Thank you for being so KIND to me during one of the most difficult journeys of my life. May God forever

bless you!!!

Sincerely,

Patient


It’s a Boy!!!

Congratulations to Alumni, Kathleen Settle, MD on the birth of her son Tristan , who weighed 7lbs, 12 oz. and was 21 inches long.

The 3rd Annual Alumni Association Event will be held on

October 29th at "The Top of the Hub" in the Prudential Building in

Boston, MA, at 6:30PM, almost 52 floors above the “Back Bay”.

Come and enjoy the best view of Boston's skyline.

Call Jill Rosenberg for any

questions about the event at

410-328-7618


Maryland Proton Treatment Center (MPTC) Constructio n Update

We are all very excited about the work being done in the BioPark for the Maryland Proton Treatment Center. Some of us have had the opportunity to tour the grounds and see the progression. Starting in September, we are offering all of our faculty and staff the opportunity to tour the site. The first tour will be held September 27th at 5PM . You must RSVP to Jill Rosenberg by September 24th if you are interested in touring, in order to prepare the hard hats and construction vests. We will meet in the main waiting area in our department at 4:40 and will walk over together at 4:45PM. We will have more tour dates available soon if this date does not work for you. Feel free to contact Jill with any questions at 410-328-7618 or [email protected].

MPTC opens in March of 2015


New Leadership Role

In July, Dr. Steven Feigenberg started in the newly created leadership role as "Director of Emerging Technology ". Dr. Feigenberg has demonstrated a commitment and passion for the evaluation and development of technology in his role as Director of our Stereotactic Radiation program. In this role, Dr. Feigenberg will work with senior departmental leadership to evaluate, communicate and introduce new technology in alignment with departmental clinical, research and educational missions.

He will create and implement strategic and project work plans for new technology as well as anticipate and manage hurdles associated with the implementation of the new technology. In addition he will also develop metrics to evaluate effectiveness and appropriate utilization of new technology.

Please join us in congratulating and supporting Dr. Feigenberg in this new departmental leadership role.

Leading Specialty Journal Publication Announcement The University of Maryland Department of Radiation Oncology had "six" publications featured in the April 2012 issue of our leading specialty journal, the International Journal of Radiation Oncology, Biology and Physics. Enjoy and be proud as we continue to achieve excellence across ALL our missions and do so with your great support and effort.

Clinical Practice Guidelines Update:

After more than 1 year of collaborative effort, our Clinical Practice Guidelines are essentially complete. We have now moved on to phase II, the clinical implementation of these guidelines. This implementation will be the theme of our clinical process retreat that will take place on November 27, 2012. Finalized guideline documents have been saved to both the Public Folder and the Document Library (located at the following links). As other documents are finalized (Dosimetry and Therapy addenda that are in progress) they will be saved at these locations: In the Public Folder: \\stccl1srv7\RADONC\Public\Clinical Practice Guidelines\Final Site-Specific Practice Guidelines In the Document Library: f\\radonc-doclib\Alfresco\Clinical Guidelines


Grant Approved

Congratulations to Dr. Vujaskovic for receiving his first grant as faculty here in the Department of Radiation Oncology. Dr. Vujaskovic was approved by NASA Shared Services Center (NSSC) for a $200,000 grant to assume the role of lead Principle Investigator (PI) for his work on “Radioprotective Effects of Nanoceria on Neutron and Photon Induced Lung Damage” .

2012 Chicago Multidisciplinary Symposium in Thoraci c Oncology

We are pleased to announce that two of our residents presented at the 2012 Chicago Multidisciplinary Symposium in Thoracic Onc ology.

Dr. Nichols presented her study, “Marital Status is an Independent Predictor of Survival for Patients Undergoing Defin itive Chemoradiation for Stage III Non-Small Cell Lung Ca ncer (NSCLC)” , which was highlighted during the press program. Dr. Nichols summarized her study for reporters in a News Briefing on Thursday, September 6, from 7:00 a.m. – 7:45 a.m. Central Time.

We would also like to congratulate Dr. Boggs on having his abstract titled: “Stereotactic Body Radiotherapy (SBRT) Using Tomothe rapy for Early Stage NSCLC: The Utility of Mid-fraction CT Scans t o Assess Intra-fraction Tumor Motion”, selected for Poster Session at the 2012 Chicago Multidisciplinary Symposium in Thoracic Oncology . The meeting was held on September 6-8, 2012 at the Chicago Marriott Downtown Magnificent Mile in Chicago.


Please Save the Date:

University of Maryland Radiation Oncology

State of the Department Address:

The Power of Partnerships, Passion and People!

A 10 Year Review and a Glimpse in to the Future

Friday, September 21st, 2012

5:30 PM in the Shock Trauma Auditorium

Reception to Follow in the Radiation Oncology

Waiting Area

We hope to see you there!


In each edition of the BEAM we are pleased to highl ight the amazing strength and determination exhibited by our younger patients, their families, and our outstanding facul ty and staff who have dedicated their lives to making a differen ce.


Maryland Proton Treatment Center Groundbreaking Cer emony

The Maryland Proton Treatment Center Groundbreaking was held at the BioPark on April 17, 2012. Over 550 guests were in attendance including, the Governor of Maryland and the Mayor of Baltimore.

Please visit the link below to see the Chancellor of Maryland, Dr. Brit Kirwan, as the guest speaker as he and his wife Patty "Ring in Hope".

http://somvweb.som.umaryland.edu/absolutenm/templates/?a=1849


MPTC Groundbreaking Ceremony Cont’d...


Baltimore Washington Medical Center Bell Ceremony

On June 26, 2012, BWMC celebrated the installation of their “End of Treatment” bell. Elizabeth Nardone, a breast cancer patient of Dr. Oh’s , participated in this ceremony along with Karen Olscamp , President and CEO at BWMC and Dr. Regine . This bell has been very well received by the patients, their loved ones, and the faculty and staff.


Radiation Oncology Summer Picnic

On Saturday, June 30th, 2012 the Department gathered at “Cascade Lake” for our Annual Department Picnic. The picnic was a great success, and special thanks to all of our social committee members for all of their hard work.


Upcoming Events:

Upcoming Visiting Professors:

David Hodgson, MD, MPH

Associate Professor


Princess Margaret Hospital

Toronto, ON

Date: January 9, 2013

Time: 5:00 PM to 5:45 PM

Location: Nicola Regine Conference Room

Lecture Topic: Lymphoma

Jeff Michalski, MD, MBA

Professor and Vice Chair


Washington University

School of Medicine, St. Louis, MO

Date: January 10, 2013

Time: 8:00 AM to 8:45 AM

Location: Nicola Regine Conference Room

Lecture Topic: GU

Annual Graduation Dinner

Faculty and residents attended the Annual Graduation Dinner on Friday, June 22, 2012 at “Kali’s Court”. Congratulations and farewell wishes were shared with Drs. Grace Kim and Zain Husain, and their families.


Upcoming Events:

SAVE THE DATE!

The Department of Radiation Oncology at is hosting

“The Radiation Oncology Symposium – Best of 2012”

Date: Thursday, January 10, 2013

Time: 12:30 p.m. to 5:30 p.m. with reception to follow

Location: University of Maryland Southern Management Corporation Campus Center (SMCCC), located at 621 West Lombard Street in Baltimore, MD

For more information regarding registration please contact Duane Henderson at : (410) 328-6928 or by e-mail at [email protected]

**All members of the Alumni Association receive free registration to future Radiation Oncology

Symposium’s– Best of Review Courses**

Nicola Regine Teacher of the Year Award

The Annual Nicola Regine Teacher of the Year Award was presented on June 22, 2012 to Dr. Karl Prado at the Annual Graduation Dinner. Dr. Prado was presented with a framed certificate from the residents, and his name will be added to the Nicola Regine Teacher of the Year plaque in the Nicola Regine Conference room.

The Teacher of the Year Award was created to identify and recognize outstanding teachers and mentors of radiation oncology residents. Congratulations to Dr. Prado!

Annual Resident Research Award

Dr. Elizabeth Nichols was awarded the Annual RSNA Research & Education Foundation Roentgen Resident Research Award at the Annual Graduation Dinner on June 22, 2012.

The purpose of the award is to recognize and encourage outstanding residents and fellows in radiologic research. Dr. Nichols received a personalized award plaque. Congratulations, Dr. Nichols!

New Residents

Please welcome our two new radiation oncology residents to the Department, Drs. Jolinta Lin and Alexander Engelman . Drs. Lin and Engelman started their residency with us on July 2nd. Dr. Lin graduated medical school from the University of Maryland School of Medicine and completed her PGY-1 training at Greater Baltimore Medical Center.

Dr. Engelman graduated medical school from Georgetown University and completed his PGY-1 training at Georgetown University Hospital in Washington, DC. Both are very excited to be on board!


First Radiation Oncology Medical Physics Resident

Please welcome our first radiation oncology medical physics resident to the Department, Dr. Xiaocheng Yang . Dr. Yang started his residency in medical physics residency program on July 2nd. Dr. Yang graduated with a PhD from West Virginia University and most recently completed a postdoctoral fellowship in our Department under the supervision of Drs. Byong Yong Yi and Cedric Yu . Dr. Yang is very excited to be the first medical physics resident in the newly created medical physics residency program. Dr. Yang will be training in the medical physics resident program for the next two years.

Medical Physics Residency Program Announcement

Congratulations to Dr. Byong Yong Yi as he assumes the role of Director of the Medical Physics Residency training program. Dr. Yi has clearly demonstrated a commitment and passion for the education of our trainees. He assumes this leadership position as we navigate our newly created residency program through its accreditation process. In his role, Dr. Yi will be working with many of you and our program leaders to ensure success for our Residency program. Please congratulate Dr. Yi in this new leadership role serving our Educational Mission.

New Chief Resident

Please join us in congratulating Dr. Michael Rutenberg on being appointed chief resident for the academic year 2012-2013. Dr. Rutenberg officially took over this role on July 1, 2012 and will undoubtedly continue to foster the tradition of excellence that embodies our residency program.

Drs. Wendy Citron and Navesh Sharma would like to thank Dr. Liz Nichols for her outstanding leadership as chief resident this year. She has been instrumental in helping implement several constructive changes in the educational program and has led by example.

New Resident Rotation Schedule

As many of you are aware, a new resident rotation schedule was recently distributed. The schedule has a list of all resident rotations for the 2012-2013 academic year. If you did not receive a schedule, please contact Tina Begay at [email protected] or 410-328-1677.


9th Annual Radiobiology and Physics Review Course

In May, the Department enjoyed another successful review course, and this years attendance broke the previous years records with 100 attendees. Special thanks to all of the faculty and staff who worked so hard to make this years event a success.

Guest Speakers included Physics:

⇒ John E. Bayouth, Ph.D ., Associate Professor and Chief of Medical Physics, Department of Radiation Oncology, University

of Iowa College of Medicine

⇒ Stanley H. Benedict, Ph.D., Professor & Director of Radiological Physics, Department of Radiation Oncology, University of

Virginia Health System

⇒ Rupak K. Das, Ph.D., FAAPM, Professor, Department of Human Oncology, University of Wisconsin School of Medicine and

Public Health

⇒ Scott W. Hadley, Ph.D., Assistant Professor, Department of Radiation Oncology, University of Michigan Medical School

David J. Schlesinger, Ph.D ., Assistant Professor, Department of Neurological Surgery, University of Virginia Health System

Radiobiology:

⇒ David J. Grdina, Ph.D ., Professor, Department of Radiation and Cellular Oncology, University of Chicago

⇒ Michael C. Joiner, Ph.D., Professor, Department of Radiation Oncology, Wayne State University

⇒ Richard C. Miller, Ph.D., Assistant Professor, Department of Radiation and Cellular Oncology, University of Chicago

Reception at the Geppi Museum, Baltimore

This years guests were treated to an evening out at the “Geppi Museum” in Baltimore. The Geppi’s Entertainment Museum is dedicated to presenting the story of popular culture since the nation’s earliest days in an entertaining and educational fashion.


2012 Radiation Oncology Summer Fellowship Award

The Department of Radiation Oncology, via and Endowment Fund for Academic Excellence in Radiation Oncology, is pleased to offer the Radiation Oncology Summer Fellowship Award. The fellowship program provides either a mentored research practicum in radiobiology or a clinical research project in medical (clinical) physics or clinical radiation oncology. This year, the recipient of the 2012 Radiation Oncology Summer Fellowship Award is Duc Nguyen , 1st year Medical Student at the University of Maryland School of Medicine.

Mr. Nguyen has been spending the summer working on a project titled, “ Investigation of Low Dose Fractionated Radiation Therapy as a Chemop otentiator in Advanced GI Carcinoma ” under the supervision of Drs. Navesh Sharma and France Carrier in the Radiobiology Lab. Mr. Nguyen received a $2,500 stipend, and presented his work at this years Student Research Forum.

2012 Radiation Oncology Research Scholarship Award

The Department of Radiation Oncology, via an Endowment Fund for Academic Excellence in Radiation Oncology, recently announced a scholarship opportunity to be awarded to one medical student who has successfully completed a research project during their 2nd year, 3rd year and/or 1st semester of their 4th year. This year, the recipient of the 2011 Radiation Oncology Research Scholarship Award is Musaddiq J. Awan , 2012 graduate of the University of Maryland School of Medicine.

Dr. Awan’s winning project was titled, “ Can Breast MRI Select Patients For Treatment With Pre-operative APBI?” Dr. Awan worked on this project under the supervision of Dr. Steven Feigenberg. This project will be presented at this year’s ASTRO meeting in Boston, MA as a poster presentation. Dr. Awan received a $2,500 scholarship, which will go towards his medical school tuition.

Scholarship Award Information

Please feel free to contact Tina Begay at [email protected] or 410-328-1677 with any questions about future scholarship award information.


The University of Maryland

Department of Radiation Oncology 54th ASTRO Annual Meeting Presentations Schedule

October 28 - 31, 2012 Boston Convention and Exhibition Center, Boston Massachusetts

Poster Viewing Hours

Sunday, October 28: 10:00 a.m. - 5:00 p.m. Monday, October 29: 10:00 a.m. - 5:00 p.m. ⇒ Poster Reception: 5:30 p.m. - 6:45 p.m. Tuesday, October 30: 10:00 a.m. - 5:00 p.m. POSTER VIEWING PRESENTATIONS:

X. Yang Dosimetric Validation of Respiratory Motion Margins for Patients with

Pancreatic Cancer Using Deformable 4D Contour Propagation

A. S. Reese Deformable Image Registration as a Method to Assess Motion for Pancreatic

Cancer using 4D Computed Tomography (CT) Scans

C.G. Schinkel Dose Reduction of Rectum and Bladder Utilizing an Adaptive Strategy and Dual

-Plan Superposition When Treating Pelvic Lymph Nodes and Prostate With

IMRT

T. Diwanji Validation of high--resolution multi--modality imaging of pre--treatment lung

function in pulmonary neoplasms

S. J. Feigenberg Near 25% Complete Pathologic Response Following Preoperative Accelerated

Partial Breast Radiotherapy (apbi) Using 3 Dimensional Conformal

Radiotherapy (3D CRT)

M. Awan Can Breast MRI Select Patients For Treatment With Pre-operative APBI?

E.M. Nicholas Marital status predictors for poor outcomes in patients with Stage III Non-small

Cell Lung Cancer: The University of Maryland Experience.

2012


M. Rutenberg Salivary Preservation using Submandibular Gland Transfer and Salivary Gland

Sparing IMRT in Definitive Chemoradiotherapy for Oropharyngeal Cancer

D. Boggs Stereotactic Body Radiotherapy (SBRT) using Tomotherapy for Early Stage

NSCLC: the utility of mid fraction CT scans to assess intra-fraction tumor

motion.

Yuan-Chia Kuo Liposome-based Nanoprobe with Antibody Conjugation Combined with MRI

Contrast Encapsulation as a Potential Diagnostic and Therapeutic Agent for

Human Head and Neck Cancer Cells

W. Lu Pre-Chemoradiotherapy FDG PET/CT Can Not Identify Residual Metabolically

Active areas in Patients with Locally Advanced Esophageal Cancer

E. Christenson Preoperative Accelerated Partial Breast Radiation Is Associated With

Decreased Cd8+ Cells In Patients With Early Breast Cancer

Sunday, October 28, 2012

1:45 p.m. - 3:15 p.m. Digital Poster Discussion 02 - Lung

1019: Trimodality Therapy for Locally Advanced Non-small Cell Lung Cancer (NSCLC): Predictors of Surgical Dro p Out

Melissa Liriano

Monday, October 29, 2012

11:00am- 12:30pm Scientific Session J: Ear ly Stage Local Therapy

82: Improved Survival With Adjuvant Radiation in E lderly Women With Early-stage Breast Cancer Randi Cohen, M.D.

2012


11:00am- 12:30pm Scientific Session N- SBRT: Efficacy/Response Asses sment/ Toxicity Co-moderator: Steven Feigenberg, M.D.

Wednesday, October 31, 2012 12:30 p.m. - 1:30 p.m. Meet the Professor Luncheon

Mohan Suntha, M.D.

1:30 p.m. - 3:00 p.m. Scientific Session UU - Pediatrics- Non-CNS Tumors

2:50 p.m. 404: Evaluation of the Use of Carbon-11 Methionine PET Scans in Pediatric Patients with Craniopharyngioma

Benjamin Laser, M.D.

2012


It takes all of us to make a DIFFERENCE

It takes all of us to show we CARE

It takes all of us to share JOY

It takes all of us to LEAD the way

It takes all of us to HELP give hope

It takes all of all of us to show compassion and ha ve PATIENCE

Its takes all of us!

Locate the above, underlined words in the word search below and record your time. Inform Carl Benbow of the time it took you to complete the word search and he will compare your time against others and decide a winner on September 21, 2012 . The person who records the fastest time will receive a prize. Carl can be contacted at 410-328-2658 or by e-mail at [email protected].

L F L K Y Q P W A E I O P A T I E N C E

S E R A C X D N Z S T T Q R Y O E A M I E D H O Y R Z I E N N L J R E T L L Y L

B N E F O E C H P L A Q F M V U M U LQ S I W S Y B G L E L

D R F E N O V H H F

Congratulations!!!

We want to congratulate Eric Colson on his upcoming graduation in September from the University of Phoenix. He will be receiving a Bachelor of Science in Health Care Administration/H ealth Information Systems .

He plans to apply to University of Maryland’s graduate program and partake in their Health Administration and Business management dual degree.


Introducing our newest Division

It is official as of August 2012 – The department has a new division: “The Division of Translational Radiation Sciences (DTRS)” – under the direction of Dr. Zeljko Vujaskovic.

We are pleased to announce that everyone on the 7th floor of the Bressler Building has moved to the 8th floor. There is currently 8,000 sq. ft. of new lab space undergoing renovation in association with DTRS. There will be an official “open house” planned for this coming spring once it is complete. Special thank you to all of the faculty and staff who worked so hard to make this transition a success!

Please welcome the newest members of our DTRS Faculty and Staff

Please welcome our new director, Dr. Zeljko Vujaskovic , and our newest faculty and staff members.

Miek Ouwerkerk-Segers Research Program Administrator

Esther Moses Office Manager

Zeljko Vujaskovic, M.D., Ph.D. Professor, and Director

Lauren Jackson, Ph.D. Assistant Professor

Masaki Kimura, M.D., D.Med. Sc. Research Associate

Xiuwu Zhang, M.D., Ph.D. Assistant Professor


Oral Presentation

1. Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) for High-Resolution Lung Perfusion Evaluation in Pulmonary Neoplasms Prior to Radiotherapy

T Diwanji, S Feigenberg, W D'Souza, N Mistry

2. Validation of 4D Computed Tomography (4D-CT) to Evaluate Fractional Regional Ventilation Against the Clinical Gold-Standard Scintigraphy V/Q

T Diwanji, S Feigenberg, W D'Souza, N Mistry

3. Breathing Maneuvers Result in Regional Changes in Ventilation as Assessed by 4D-CT

N Mistry, S Pokharel, T Diwanji, S Feigenberg, W D'Souza

4. Personalized Utility Function for Radiotherapy Based On Pulmonary Ventilation of Locally Advanced Lung Cancer Patients

H Zhang, T Diwanji, N Mistry, W Lu, W D'Souza

5. 4D-CT Simulation Using Individually Optimized Contrast Enhancement (CE): A Phantom Study

M Xue, W D'Souza, G Lasio, P Klahr, W Lu

6. FDG-PET Histogram Distances: Novel Predictors of Tumor Response to Chemoradiotherapy

S Tan, H Zhang, S Kligerman, W Chen, G Kim, S Feigenberg, W D'Souza, M Suntharalingam, W Lu

7. Can Pre-Chemoradiotherapy FDG PET/CT Identify Residual Metabolically Active Areas Within Individual Esophageal Tumors?

W Lu, S Tan, S Kligerman, W Chen, S Feigenberg, H Zhang, M Suntharalingam, W D'Souza

8. Modeling Pathologic Response of Locally Advanced Esophageal Cancer to Chemoradiotherapy Using Spatial-Temporal FDG-PET Features, Clinical Parameters and Demographics

H Zhang, S Tan, W Chen, S Kligerman, G Kim, W DSouza, M Suntharalingam, W Lu

9. Mechanistic formulation of a linear-quadratic-linear (LQL) model for high fraction doses relevant to stereotactic radiotherapy

Mariana Guerrero and Marco Carlone

10. Personalized Utility Function for Radiotherapy Based on Pulmonary Ventilation of Locally Advanced Lung Cancer Patinets

H Zhang, T Diwanji, N Mistry, W Lu, W D’Souza

Poster Presentations

1. Dosimetric and Geometric Evaluation of a Novel Stereotactic Radiotherapy Device for Breast Cancer: The GammaPod

Y Mutaf, C Yu, J Zhang, B Yi, K Prado, W D'Souza, W Regine, S Feigenberg

2. Utilizing Machine Learning Techniques for Beam Angle Selection in Radiation Treatment

R Meyer, S Gao, L Shi, W D'Souza, H Zhang

3.Compute the Optimal Threshold for PET Functional Volume Delineation

S Tan, W Chen, W D'Souza, W Lu

4. 4D Dynamic Arc of Non-Modulated Variable-Dose-Rate Fields for Lung SBRT: A Feasibility Study

B Yi, X Yang, Y Niu, C Yu

5. Compensation of Target Distortion of Pancreatic Tumor in Free-Breathing CT Using 4D Contour Propagation

X Yang, A Reese, Y Mutaf, B Yi

6. Are the Calculation Methods for Determining Tissue-Maximum Ratios From Percent Depth Dose Valid for Flattening Filter-Free Photon Beams?

E Kinsey, M Guerrero, K Prado, B Yi

7. Delivery Efficiency of StereoArc Stereotactic Body Radiotherapy (SBRT)

E Kinsey, X Yang, K Prado, S Feigenberg, B Yi

8. Is BJR Supplement #25 Recommendation for Megavoltage Energy Independent Scatter Factor Still Valid for Flattening Filter Free Photon Beams?

H Chung, B Yi, K Prado

9. Is Rotational IMRT More Susceptible to Tumor Motion Than Dynamic IMRT?

G Betzel, B Yi, C Yu

10. Comprehensive Evaluation of EPID Image Acquisition for Integrating and Temporal Dosimetry of Fixed-Gantry IMRT and ArcIMRT

I Yeo, J Jung, B Yi, B Patyal

2012 American Association of Physicists in Medicine (AAPM) – Abstract Acceptance

The following abstracts were accepted to the AAPM, which was held in Charlotte, N.C., in July 2012.


First Place Award

Wei Lu, PhD received a first place poster award for, “Tumor response models in predicting pathologic response of esophageal cancer to neoadjuvent chemoradiotherapy using spatial-temporal FDG-PET features”, at the 59th Society of Nuclear Medicine, Advancing Molecular Imaging and Therapy Annual Meeting 2012.

Please Welcome

We would like to welcome our newest member to the physics division, Shifeng Chen, PhD, Assistant Professor. Dr. Chen comes to us from the University of Nebraska Medical Center, in Omaha, N.E., and he completed his Post-Graduate clinical training at Duke University Medical Center in Durham, N.C.

Update on the Development of Tumor Response Models

In collaborating with Dr. Wei Lu and Dr. Warren D'Souza , Dr. Hao Zhang developed tumor response models using quantitative spatial-temporal FDG-PET features to accurately and precisely predict pathologic response to concurrent chemo-radiotherapy (CRT) for locally advanced esophageal cancer patients.

By using quantitative PET/CT image features they were able to accurately and precisely predict pathologic tumor response in esophageal cancer patients undergoing concurrent CRT. This prediction has the potential to alter current clinical practice standards by identifying patients in whom surgery may be safely deferred.

Congratulations for your efforts and continued dedication.

Research Grant Approval

The University of Maryland, College Park (UMD) and Baltimore (UMB) campuses have recently been awarded a $75K grant to a research team led by Dr. Mistry (Rad Onc, UMB) and Dr. Varshney (Comp Science, UMCP) to improve the reliability of diagnosing aggressive prostate cancer. The intent of this new initiative is to promote the structured collaboration between UMD and UMB and to advance the institutions’ joint goals in research and innovation by fostering creative teams of investigators working across disciplinary boundaries and campuses.

The team comprises of physicists, physicians and scientists from Radiation Oncology, Radiology, and Urology from UMB and computer scientists from UMCP. The researchers are developing technology to pinpoint the exact location of suspected aggressive cancerous tissue using magnetic resonance imaging and advanced machine learning tools.

By laying the groundwork for positively identifying cancer foci, the findings from this proposal have the potential to alter the paradigm for prostate screening and patient management.


Graduation Update

Kate Malinowski , advised by Warren D’Souza, PhD , has graduated with her PhD from the Fischell Department of Bioengineering at the University of Maryland College Park. Dr. Malinowski has accepted a position with Varian Medical Systems, in Clinical Research Collaboration Management, in Seattle.

New Addition

Congratulations to Hao Zhang, PhD and his family on the birth of their son Ethan , who was born on March 29th. (See picture on page 38)

Awards and Recognition

The Physics Department is pleased to announce that after presenting our work entitled:

“Modeling Pathologic Response of Locally Advanced E sophageal Cancer to Chemoradiotherapy Using Spatial-Temporal FDG-PET Features, Clinical P arameters and Demographics ”,

at this year's AAPM annual meeting, that we received an award for "Best In Physics", which was awarded to the top 5 abstracts in each of the three categories: Imaging, Therapy and Joint Imaging and Therapy.

In addition, this years presentation was selected to the Science Council Research Symposium and was presented by our newest faculty, Hao Zhang, Ph.D. Presentations in this session included the top 10 proffered abstracts from the entire meeting. Later Dr. Zhang's presentation was featured in MedicalPhysicsWeb (http:/medicalphysicsweb.org/cws/article/opinion/50480) and the Society of Nuclear Medicine and Molecular Imaging (SNMMI) SmartBrief.

Farewell Dinner:

The downtown Dosimetrists team enjoyed a night out together at “Mem Sahib” in July to enjoy great food and company before Steve Meerdink's last day with the department. He will be greatly missed! We wish him the best at his new job in Spokane, Washington.

Dosimetry Update:

Special “THANK YOU” to all the Physicists, Therapists, Nurses, and Physicians who made all the Dosimetrists at the downtown site feel special and appreciated on “National Dosimetry Day” on August 15, 2012 ! It is a pleasure to work with such wonderful people!"

Recent Graduate

Congratulations to Kim Marter’s son Justin who recently graduated from Reservoir High School. He will attend the University of Maryland Eastern Shore in the Fall where he will major in architectural engineering.


Successful RTOG Audit

We would like to congratulate all of the members of our research team for the completion of a very successful RTOG audit. We have been granted an acceptable audit with a three year review process.

Clearly, the effort that was put in over the last few months in preparation for this audit was well worth it and the entire team should be recognized.

At the exit interview, the auditor went out of her way to complement the group on the excellent care of our patients and their respective treatment charts, especially given the volume of patients that are treated at all sites including our community practices at CMRO and BWMC which accrue significantly to our clinical research program.

Please join us in thanking the research team for their extraordinary efforts as we continue to focus our department on the critical role of clinical research.

Clinical Trials:

The January-August 2012 active study accruals are:

32 RTOG patients (33 case credits) and 16 UMGCC patients.

Total of 48 patients accrued to clinical trials in the department of Radiation Oncology.

The following RTOG/GCC studies have been recently I RB approved and are now open to accrual:

GCC 1043 IS NOW OPEN TO ACCRUAL

Magnetic Resonance Imaging for Evaluating Tumor and Node Response and Normal Tissue Function to Concurrent Chemotherapy and Radiation Therapy in Head and Neck Cancer.

Primary Objective - To assess whether advanced MR imaging techniques can be used to determine tumor and node response (i) 4-5 weeks following initiation of concurrent chemoRT and (ii) after completion of chemoRT in head and neck cancer by comparing the change in parameters associated with MR images at the appropriate time point relative to the respective baseline parameters (prior to therapy) with the physical exam and PET imaging (that are performed as standard of care) performed at 3-4 months following the completion of therapy.

RTOG 1021 IS NOW OPEN TO ACCRUAL

A Randomized Phase III Study of Sublobar Resection (+/- Brachytherapy) versus Stereotactic Body Radiation Therapy in High Risk Patients with Stage I Non-Small Cell Lung Cancer (NSCLC)- This is a joint trial conducted by the Radiation Therapy Oncology Group (RTOG) and the American College of Surgeons Oncology Group (ACOSOG).

Primary Objective: To ascertain whether patients treated by SBRT have a 3-year overall survival rate that is no more than 10% less than patients treated with sublobar resection

RTOG 1114 IS NOW OPEN TO ACCRUAL

Phase II Randomized Study of Rituximab, Methotrexate, Procarbazine, Vincristine, and Cytarabine With and Without Low-Dose Whole-Brain Radiotherapy for Primary Central Nervous System Lymphoma

Primary Objective: To determine median progression-free survival (PFS) in both arms on an intent-to-treat basis. PFS will be defined as the interval from randomization to progression or death, whichever occurs first.


Please welcome our New Radiation Therapist

We would like to introduce Elizabeth Mitchell as our newest senior radiation therapist . Liz worked at the Helen P. Denit Cancer Center at Montgomery General Hospital since 2001 and has over 15 years of experience in the field. We are very excited to have Liz as part of our Radiation Therapy Team. Please stop by the simulation rooms to give her a warm welcome to her.

Please welcome Andrew Cox, RT who is a recent graduate of CCBC. This is his first RT position, and prior to attending CCBC he was in the Marine Corp. We would also like to introduce Teresa Sanwo, Assistant Chief Radiation Therapist at CMRO. Teresa comes to us with over 13 years of experience in radiation therapy and most recently worked at NIH/NCI managing global cancer programs. We are excited to have Teresa join us.

Welcome Back!

We want to welcome back “Racee” Taylor . We have all missed her and we are excited for her

return.

Farewell

In June, Brittany Leitnaker, one of our talented senior therapists, decided to pursue a career with Vision RT. Faculty

and staff gathered at the “Alewife”, in Baltimore to celebrate Brittany’s new position, and to say farewell.

Also, Chuck Evans has recently returned from his vacation to Germany. Chuck and his daughter

Emily traveled throughout Germany and enjoyed many of the sites and attractions. We welcome Chuck

back from abroad and we are excited to hear all about his trip.


Please Welcome Alena Fuhram, BSN, RN, CPHON, CPN recently joined the nursing team to work with Dr. Young Kwok . She was recently employed by Hyundai Cancer Institute at CHOC Children's in Orange, CA as an inpatient clinical nurse. Nicole Johnson -Nesmith also recently joined the nursing team to work with the physician scientists. She was recently employed as a clinical nurse at North Arundel Health and Rehabilitation Center.

Congratulations

Congratulations to Renee Kwok and Laura Lunz for becoming Senior Clinical Nurses, and for recently passing the Radiation Oncology Certification Exam.

Flu Season Update

Flu Season 2012 is expected to start the first week October. Vaccination is Mandatory. You will be able to review flu health screening forms and vaccine information statements (VIS) before receiving the vaccine. If you are unable to accept the flu vaccine, you can decline vaccination for one of three reasons: allergy to vaccination, religious reasons, or if you received the vaccination at another location.

All three reasons require proof or explanation. Allergies require documentation from a healthcare provider stating the employee is allergic to chemical properties of the flu vaccine. If you had a flu shot else where, you must have documented proof. For religious objections, staff members will be asked to provide a document from their clergy stating the contraindication to their religious doctrine.


Lynn Gill 410.706.5217 410.706.6727 [email protected]

Yana Karabelas 410.706.5228 410.706.6728 [email protected]

Vida Mensah 410.706.5219 410.706.6727 [email protected]

Mike Minkove 410.706.5218 410.706.6727 [email protected]

Kim Rosko 410.706.5227 410.706.6728 [email protected]

Martha Vaughn 410.706.5677 410.706.6718 [email protected]

Main Fax 410.706.6718

1. The department phone roster has been updated with this information.

2. There is a mail bin in Charlotte/Michelle’s area. The courier service that currently stops at all our locations has added a stop to the new space at the BioPark to facilitate the delivery of original documents for processing.

We have a touchdown space in the department, C022 (the room across from Bin, Antigoni & Donnica). A schedule of when someone will be in that office is forthcoming and will be posted outside the office.

Maryland Legislature made a mid-year tax change for employees

On 5/22/12 the governor of Maryland signed legislation that increases the state income tax rates, retroactive to January 2012. The individuals impacted are single filers with earnings of $100,000 or more and joint filers with earnings over $150,000. The highest tax rate, as well as the supplemental wage rate, increased from 5.5% to 5.75%.

Although the state has issued new withholding tables that are to be used for the remainder of the year, EMPLOYERS HAVE NOT BEEN REQUIRED to make any adjustments to the withholding amounts deducted prior to the withholding tables availability. Employees may want to review their tax bills from last year and submit a new Maryland Exemption Certificate, Form MW507 with additional withholdings to be deducted for the remainder of the year.

The State of Maryland has stated penalties and interest will not be assessed on 2012 income tax form underpayments, but you may find yourself with a much smaller refund or owe taxes with your 2012 income tax filing if you don’t review and make an adjustment.

We’ve Moved

The Finance/Admin/HR group has successfully relocated to the BioPark!! The office is right next to the location of our future Maryland Proton Treatment Center at 800 W. Baltimore Street, Suite 409. Our NEW phone & fax information:


Updates:

BWMC closed this fiscal year with the highest volumes on record and we exceeded our RVU budget by 28.5%! In addition, our average patient satisfaction score for the fiscal year was 94.1% which means that 94.1% of the patients surveyed scored us as a 9 or 10 on a scale of 10. This is an outstanding accomplishment!

BWMC went live on EPIC on Sunday, August 12 at midnight. Radiation Oncology is currently utilizing EPIC for order entry and e-prescribing only. However, we will be able to view inpatient information as well.

Please Welcome

We would like to welcome our newest radiation therapists. Nicole Dorer has accepted a position as a full time therapist.

Recent Promotion

Kennecia Shaw was promoted to the position of Front Office Supervisor and is now responsible for overseeing the front office staff and all front office operations.

Jenae Quinn was promoted to the position of Senior Therapist.

Also, Sarah Newberger and Welton McCready have joined us as PRN therapists, and we are very happy to have them join our team.


Farewell

Angelique Davis Taylor , assistant chief therapist would like everyone in the department to know “Honestly, there aren't any words to sum up how I feel about each of you and the time we've spent together. All I can say is thank you for welcoming me into your group. This has been one of the best work experiences ever and I will miss everyone at CMRO and the University!”

We have also enjoyed her presence and the professionalism. Angelique left with a heavy heart, but family needs called her away.

Dr. Courtney Bui will be joining the faculty of the University of North Carolina at Chapel Hill, her medical school alma mater, in September. Her last day at CMRO will be 9/14/12. She will be working with the Rex Health Care system in Raleigh, NC, which is the largest provider of cancer services in the area. She will be moving closer to her family, so her children, Ian, Audrey, and Ava can spend more time with their grandparents, aunts, uncles and numerous cousins!

Ozana Jovanovich , our patient care technician, who cared for all, including the staff, has moved on to return to her home country. Ozana will be missed by all.

Thank You

We would like to thank Renee Kwok, RN for all the hard work and assistance she is providing as we transition through building our nursing team. She has been a tremendous help to us. We know that Dr. Regine and his patients miss her a lot!!


Clement B. T. Knight, M.D., MRCP, MRCPath August 2, 1950 – August 9, 2012

It is with great sadness that we acknowledge the death of a tremendous clinician, colleague, mentor and friend; Clement B. T. Knight, M.D. Clem joined Maryland Hematology Oncology, the medical oncology practice that "shares a back hall” with CMRO, in 1993. He practiced medicine the way he lived his life; with curiosity, energy, dedication and joy. If a clinical situation puzzled him, he would elicit opinions up and down the back hall, within the building, across the country, and across the oceans. His patients understood his concern for them and cherished him for it. He had a great sense of humor and an infectious giggle. He kept a beautiful garden and enjoyed fishing and motorcycling. He adored his wife, Mattie, and was very proud of his son and daughter, Jonathan and Nicki, and his 10 month old 28 pound grandson, Sebastian. He is also survived by his mother, two brothers and a sister. Clem was a large man, literally and figuratively, and you always knew when he was in the building, but the real measure of this great man was the depth of his principles and his integrity. He strove relentlessly for intellectual rigor and to do what was right. Clem loved his work, his hobbies, his patients, his friends and his family. His was a life well-lived. We will miss dear Clem, but we will be ever thankful that we knew him. Sally B. Cheston, MD


1. Abdelmohsen, K., Tominaga, K., Lee, E-K., Srikantan, S., Kang, M.J., Kim, M., Selimyan, R., Martindale, J., Yang, X., Carrier, F., Zhan, M., Becker, K., Gorospe, M. Enhanced translation by Nucleolin via G-rich elements in coding and non-coding regions of target mRNAs. Nucleic Acids Res. Oct. 2011, Vol. 39, No. 19 8513–8530. Times Cited: 1

2. Abrams RA, Regine WF. Failure to Adhere to Protocol Specified Radiation Therapy Guidelines Was Associated with Decreased Survival in RTOG 9704 – A Phase III Trial of Adjuvant Chemotherapy and Chemoradiotherapy for Patients with Resected Adenocarcinoma of the Pancreas. Int. J. Radiation Oncology Biol.Phys., 82:809-816, 2012.

3. Feigenberg SJ, Campassi C, Sharma NK, Kesmodel SB, Tkaczuk K, Yu JQ. (2012). Integration of Modern Imaging Into the Multidisciplinary Setting: The Radiation Oncology Perspective. Applied Radiol. 41(3): 24-30

4. Feigenberg SJ, Campassi C, Sharma NK, Kesmodel SB, Tkaczuk K, Yu JQ. (2012). Integration of Modern Imaging Into the Multidisciplinary Setting: The Radiation Oncology Perspective. Applied Radiol. 41(3): 24-30

5. Joseph E. Gaugler & Alejandra Eppinger & Jamie King & Tracey Sandberg & William F. Regine. Coping and its Effects on Cancer Caregiving.Springer. June 21, 2012

6. Karyn A. Goodman, M.D., William F. Regine, M.D., Laura A. Dawson, M.D.,z Edgar Ben-Josef, M.D., Karin Haustermans, M.D., Walter R. Bosch, D.Sc., Julius Turian, Ph.D, and Ross A. Abrams, M.D. "Radiation Therapy Oncology Group Consensus Panel Guidelines for the Delineation of the Clinical Target Volume in the Postoperative Treatment of Pancreatic Head Cancer". IRJOBP April 5, 2012

7. Koshy M, Rich S, Merchant E, Mahmood U, Regine W, and Kwok Y . Post-operative Radiation Improves Survival in Children Younger Than 3 Years with Intracranial Ependymoma. Journal of Neuro-oncology. 2011;105(3):583-90. Epub 2011 June 3.

8. Lim S, Ma SY, Jeung TS, Yi B.Y., Lee SH, Lee S, Cho SJ, Choi J, Development of a one-stop beam verification system using electronic portal imaging devices for routine quality assurance, Medical Dosimetry, Jan 2012

9. Lubbe W, Cohen R, Sharma NK, Ruth K, Peter R, Li J, Buyyounouski M, Kutikov A, Chen D, Uzzo R, Horwitz E. (2011) Biochemical and Clinical Experience with Real-Time Intraoperatively Planned Permanent Prostate Brachytherapy. Brachytherapy. In Press/electronic publication available PMID 21727033.

10. Matthew Koshy, M.D., Shayna E. Rich, Ph.D., Usamamahmood, M.D., and Young Kwok, M.D.-Declining Use Of Radiotherapy In Stage I And Ii Hodgkin’s Disease And Its Effect On Survival And Secondary Malignancies 2012"

11. Muvarak N, Nagaria P, Rassool FV. Genomic instability in chronic myeloid leukemia: targets for therapy? Curr Hematol Malig Rep. June 2012, 7(2):94-102. PMID: 22427031

12. Neuner GA, Badros AA, Meyer TK, Nanaji NM, Regine WF. Complete resolution of laryngeal amyloidosis with radiation treatment. Head Neck. 2012 May;34(5):748-52. doi: 10.1002/hed.21626. Epub 2010 Nov 10.

*Please view the following list of departmental pub lications between March and August of 2012. Special thanks to our dedicated faculty for all of there contributions to the field of Radiation Oncology.


13. Nichols EM, Mirmiran A, Garofalo MC, Sun CJ, Hatten K, Wolf J. Recurrent myxoid liposarcoma of the buccal mucosa in a young boy: A case report and review of the literature. ENT Journal 2011 Dec; 90(12): E27-E31.

14. Nichols RC Jr, Huh SN, Prado KL , Yi BY , Sharma NK, Ho MW, Hoppe BS, Mendenhall NP, Regine WF. (2012) Protons Offer Reduced Normal-Tissue Exposure for Patients Receiving Postoperative Radiotherapy for Resected Pancreatic Head Cancer. Int. J. Rad. Oncol. Biol Biophys. In Press, electronic publication available PMID 22245197 Oncology Biol.Phys., 82:(5)1823-30, 2012.

15. Ross A. Abrams, MD., Kathryn A. Winter, M.S., William F. Regine, M.D., Howard Safran, M.D., John P. Hoffman, M.D., Robert Lustig, M.D., Andrea A. Konski, M.D., Al B. Benson, M.D., John S. MacDonald, M.D., Tyvin A. Rich, M.D., and Christopher G. Willett, M.D.- failure to adhere to Protocol Specified Radiation Therapy Guidelines was Associated with Decreased Survival in RTOG-9704-A Phase III Trial of Adjuvant Chemotherapy and Chemoradiotherapy for Patients with Resected Adenocarcinoma of the Pancrease (February 2012)

16. Sharma NK, Regine WF. Radiation therapy in resectable/resected pancreatic adenocarcinomas: clearing up the fog. Oncology (Williston Park). 2011 Jul;25(8):727-8, 730.

17. Showalter TN, Winter K, Berger AC, Regine WF, Abrams RA, Safran H, Hoffman JP, Benson AB, MacDonald JS, Willett CG. The Influence of Total Nodes Examined, Number of Positive Nodes, and Lymph Nodes, and Lymph Node Ratio on Survival after Surgical Resection and Adjuvant Chemoradiation for Pancreatic Cancer. A Secondary Analysis of RTOG 9704. Int J. Radiation Onclogy Biol Phys., 81:(5) 1328-35, December 2011.

18. Suntharalingam M, Paulus R, Edelman MJ, Krasna M, Burrows W, Gore E, Wilson LD, Choy H. "Radiation Therapy Oncology Group Protocol 02-29: A Phase II Trial of Neoadjuvant Therapy With Concurrent Chemotherapy and Full-Dose Radiation Therapy Followed by Surgical Resection and Consolidative Therapy for Locally Advanced Non-small Cell Carcinoma of the Lung”. Int J Radiat Oncol Biol Phys. 2012 Apr 27

19. Susannah Yovino, M.D.,* Bert W. Maidment, 3rd, B.S.,* Joseph M. Herman, M.D., M.Sc., Naimish Pandya, M.D.,* Olga Goloubeva, Ph.D.,* Chris Wolfgang, M.D., Ph.D.,y Richard Schulick, M.D., Daniel Laheru, M.D., Nader Hanna, M.D.,* Richard Alexander, M.D.,* and William F. Regine, M.D.* "Analysis of Local Control in Patients Receiving IMRT for Resected Pancreatic Cancers". IJROBP. Jan 25, 2012

20. Thomas, S, Yang, A, Morgan, WF, Baulch, JE. Quantitative Proteomic Analysis of Mitochondrial Proteins Reveals Pro-Survival Mechanisms in the Perpetuation of Radiation Induced Genomic Instability. Free Radical Biology and Medicine, April 2012.

21. Tobin LA, Robert C, Rapoport AP, Gojo I, Baer MR, Tomkinson AE, Rassool FV. Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias. Oncogene, May 2012, doi: 10.1038/onc.2012.203. PMID: 22641215

22. Tsai HC, Li H, Van Neste L, Cai Y, Robert C, Rassool FV, Shin JJ, Harbom KM, Beaty R, Pappou E, Harris J, Yen RW, Ahuja N, Brock MV, Stearns V, Feller-Kopman D, Yarmus LB, Lin YC, Welm AL, Issa JP, Minn I, Matsui W, Jang YY, Sharkis SJ, Baylin SB, Zahnow CA. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell March 2012, 20;21(3):430-46. PMID: 22439938


23. Yovino S, Poppe M, Jabbour S, David V, Garofalo M, Pandya N, Hanna N, Regine WF. Intensity-modulated radiation therapy significantly improves acute gastrointestinal toxicity in pancreatic and ampullary cancers. Int J Radiat Oncol Biol Phys 2011 Jan 1;79(1):158-62.

24. Wang L, Feigenberg S, Fan J, Jin L, Turaka A, Chen L, Ma CM. Target repositional accuracy and PTV margin verification using three-dimensional cone-beam computed tomography (CBCT) in stereotactic body radiotherapy (SBRT) of lung cancers. J Appl Clin Med Phys. 2012 Mar 8;13(2):3708. doi: 10.1120/jacmp.v13i2.3708.

Book Chapters-All

1. Arthur Boyer, Gary Ezzel, and Cedric Yu: Intensity Modulated Radiation Therapy. In Physics of Radiation Oncolgy, Ed: F Khan, Lippincott Williams & Wilkins, 2011). Book Chapter

2. Feigenberg SJ, Lango, M, Ridge, J and Mehra R. in: Cancer Management: A Multidisciplinary Approach,

Chapter 1: Head and neck tumors. Editors: Richard Pazdur, Kevin Camphausen, William Hoskins, LawrenceWagman. Melville, NY. 14th Edition, 2011.Book Chapter

3. H. H. Zhang, R. R. Meyer and W. D. D’Souza. Machine Learning Applications in Radiation Therapy in

Radiation Therapy (InTech) (2012). Book Chapter:

4. Li L, Robert C, Rassool FV. The Role of Error-Prone Alternative Non-Homologous End-Joining in Genomic Instability in Cancer, DNA Repair and Human Health, Edited by Sonya Vengrova, Croatia, InTech Open Access Publisher, Oct. 2011. ISBN: 978-953-307-612-6. Book Chapter

5. Nichols E, Patchell RA, Regine WF, Kwok Y. Palliation of Brain and Spinal Cord Metastases. In:

Principles and Practice of Radiation Oncology. Lippincott Williams & Wilkins; 6th edition. 2013 Book Chapter

6. Pamboukian, R and Carrier, F . hnRNP A18: A new pathway to regulate protein translation in cancer cells.

Molecular and Cellular Pharmacology, 4(1):41-48, 2012.Book Chapter 7. Quantitative MRI in Cancer (Imaging in Medical Diagnosis and Therapy)” Editors: Thomas E. Yankeelov,

David R. Pickens, Ronald R. Price, CRC Press Taylor & Francis Book Chapter 14: Imaging Tissue Oxygenation Status with MRI, Authors: Nilesh Mistry, C. Quarles (Sept 2011).Book Chapter

8. Yovino S, Kwok Y, Regine WF. Brain and Cranial Nerves. In: ALERT: Adverse Late Effects of Cancer

Treatment, Volume 2: Specific Normal Tissue Sites. Rubin P, Constine L, Marks L, Williams J, Hansen J. New York, NY: Springer-Verlag, 2012.Book Chapter:

*If you notice that something has been omitted from this list, please feel free to contact Duane Henderson at 410-328-6928 or by email at [email protected] so that we can make the necessary changes. Thank you.


Babies, Babies, and More Babies …

In this section of the BEAM we would like to introduce you to the newest members of the Radiation Oncology family.

Madelyn Laser

Congratulations Benjamin Laser, MD

Mathis Goetz

Congratulations Will Goetz

Ethan Zhang

Congratulations Hao Zhang, Ph.D.

Tayyab Rahman

Congratulations Shafiq Rahman


Suggestions:

We’re always looking

for recent pictures of

faculty, staff and

alumni, or new

information for the

BEAM. Contact

Duane Henderson @

[email protected]

By phone 410-328-6928, or by

fax 410-328-6911, with any contributions

or suggestions.

Each year we try to schedule the following annual events around the same time. Please mark your calendar:

⇒ Annual Alumni Association Event-

(October 29, 2012)

⇒ Annual Clinical Process Retreat

(November 27, 2012)

⇒ Holiday Party- (December 8, 2012)

⇒ Radiation Oncology Symposium– Best of 2012-

(January 10, 2013)

⇒ 10th Annual Radiobiology and Physics Review Course- (May 2-5, 2013)

⇒ Annual Education Retreat-

(May 21, 2013)

⇒ Summer Picnic- (June 29, 2013)

The Beam

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