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    THE AUTONOMICNERVOUS SYSTEM

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    Introduction

    The autonomic nervous system controls the autonomic

    functions of the body i.e. those initiated in the brain below the

    level of the cerebrum. Although stimulation does not occur

    voluntarily, the individual may be conscious of its effects. For

    example, an increase in heart rate.

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    Effector organs

    The effects of the autonomic activity are rapid and the effector

    organs are:

    smooth muscle cardiac muscle

    glands

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    Efferent nerves

    The efferent (motor) nerves of the autonomic nervous system

    arise from the brain and emerge at various levels between the

    midbrain and the sacral region of the spinal cord.

    Many travel within the same nerve sheath as peripheral nerves.

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    Divisions

    The autonomic nervous system has two divisions:

    Sympathetic - stressful situations

    Parasympathetic - during rest

    They work in an opposing manner, thereby maintaining balance

    of involuntary functions.

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    The sympathetic outflow

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    The parasympathetic outflow

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    Efferent neurones

    Each division of the autonomic nervous system has two efferent

    neurones between the central nervous sytem and the effector

    organs:

    Preganglionic neurone

    Postganglionic neurone

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    Sympathetic nervous system

    The sympathetic nervous system (SNS) is part of the autonomic

    nervous system (ANS).The sympathetic nervous system

    activates what is often termed the fight or flight response. Like

    other parts of the nervous system, the sympathetic nervous

    system operates through a series of interconnected neurons.Sympathetic neurons are frequently considered part of the

    peripheral nervous system (PNS), although there are many that

    lie within the central nervous system (CNS). Sympathetic

    neurons of the spinal cord (which is part of the CNS)communicate with peripheral sympathetic neurons via a series

    of sympathetic ganglia. Within the ganglia, spinal cord

    sympathetic neurons join peripheral sympathetic neurons

    through chemical synapses.

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    Sympathetic neurons

    Spinal cord sympathetic neurons are therefore called presynapticneurons, while peripheral sympathetic neurons are called

    postsynaptic (or postganglionic) neurons. At synapses within the

    sympathetic ganglia, preganglionic sympathetic neurons release

    acetylcholine, a chemical messenger that binds and activates

    nicotinic acetylcholine receptors on postganglionic neurons. In

    response to this stimulus, postganglionic neurons principally release

    noradrenaline (norepinephrine). Prolonged activation can elicit the

    release of adrenaline from the adrenal medulla. Once released,

    noradrenaline and adrenalinebind adrenergic receptors on peripheral

    tissues. Binding to adrenergic receptors

    causes the effects seen during the

    fight-or-flight response.

    These include:

    Pupil dilation

    Increased sweating

    Increased heart rate

    Increased blood pressure

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    Sympathetic neurones

    Two efferent neurones make up the sympathetic nervous system (SNS):

    The preganglionic neurone has its cell body in the lateral column of grey

    matter in the spinal cord between the levels of the first thoracic and 2nd or 3rd

    lumbar vertebrae. The nerve fibre of the cell leaves the cord by the anterior

    root and terminates at a synapse in one of the ganglia either in the lateral

    chain of sympathetic ganglia or passes through it to one of the paravertebralganglia. Acetylcholine is the neurotransmitter at sympathetic ganglia.

    The postganglionic neurone has its cell body in a ganglion and terminates in

    the organ or tissue supplied. Noradrenline (norepinephrine) is usually the

    neurotransmitter at sympathetic effector organs. The major exception is that

    there is no parasympathetic supply to the sweat glands, the skin and bloodvessels of skeletal muscles. These structures are supplied by only

    sympathetic postganglionic neurones, which are known as sympathetic

    cholinergic nerves and usually have acetylcholine as their neurotransmitter.

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    Sympathetic nerves

    Sympathetic nerves originate inside the vertebral column, toward themiddle of the spinal cord in the intermediolateral cell column (or

    lateral horn), beginning at the first thoracic segment of the spinal cord

    and are thought to extend to the second or third lumbar segments.

    Because its cells begin in the thoracic and lumbar regions of the

    spinal cord, the CNS is said to have a thoracolumbar outflow. Axons

    of these nerves leave the spinal cord in the ventral branches (rami) of

    the spinal nerves, and then separate out as 'white rami' (so called

    from the shiny white sheaths of myelin around each axon) which

    connect to two chain ganglia extending alongside the vertebralcolumn on the left and right. These elongated ganglia are also known

    as paravertebral ganglia or sympathetic trunks. In these hubs,

    connections (synapses) are made which then distribute the nerves to

    major organs, glands, and other parts of the body.

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    Parasympathetic nervous system

    Two neurones are involved in the transmission of impulses from

    the source to the effecter organ. The neurotransmitter at both

    synapses is aetylcholine:

    Preganglionic - long in comparison to its counterpart in the SNS

    and has its cell body in the brain or the spinal cord. Those

    originating in the brain are the cranial nerves III, VII, IX and X

    arising from nuclei in the mid-brain and brain stem, and their

    nerve fibres terminate at or near effector organs

    Postganglionic - usually very short and has its cell body eitherin a ganglion or in the wall of the organ supplied

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    Functions of the autonomic

    nervous system

    involved in many complex involuntary reflex activities

    depends on sensory input to the brain or spinal cord, and or

    motor output

    reflex action is rapid contraction, or inhibition on contraction ofinvoluntary (smooth and cardiac) muscles or glandular

    secretion

    activities are coordinated subconsciously in the brain

    some sensory input does not reach consciousness - may resultin temporary inhibition of reflex action

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    Stimulation

    Sympathetic stimulation

    allows the body to function under stress

    Fight or Flight

    Parasympathetic stimulation

    controls vegetative functions

    feed or breed or rest and response

    constant opposition to sympathetic system

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    Effects of autonomic stimulation -

    sympathetic

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    Effects of autonomic stimulation -

    parasympathetic

    Cardiovascular system

    decreases the rate and force of the heart beat

    constricts the coronary arteries, reducing the blood supply to the

    cardiac muscle

    Respiratory system

    contraction of the smooth muscle in the airway walls leading to

    bronchoconstriction

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    Effects of autonomic stimulation -

    parasympathetic

    Digestive and urinary systems

    the liver

    the stomach and small intestine

    the pancreas urethral and anal sphincters

    Eye

    contraction of the circular muscle fibres of the iris causes thepupil to constrict

    the eyelids tend to close, giving the appearance of sleepiness

    the ciliary muscles contract to facilitate near vision.