The Anti-Aging Experience · * p
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www.seppic.com TIMECODE™ The Anti-Aging Experience
Transcript of The Anti-Aging Experience · * p
illuminates
corrects
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www.seppic.com
TIMECODE™The Anti-Aging Experience
Discovery of the PalGly Molecule
SEPPIC created a biomimetic molecule for harmonious longevity:TIMECODE™
Aging is a result of a chronic silent inflammation.The inflamm’aging theory was described in the 2000s by Professor Franceschi’s Italian team. They believe that silent inflammation is responsible for 80% of age-related diseases (neurodegenerative diseases, arthritis, diabetes, osteoporosis…) as well as for skin aging. This invisible inflammation affects all individuals and accentuates with time. It is characterized by a chronic presence of interleukin-6 (proinflammatory cytokine) in the body, whose concentration increases with age.
It causes skin slackening, wrinkles, and a dull complexion.Some individuals develop a resistance to this inflamm’aging, ensuring a harmonious aging process. They are naturally resistant to stress and age-related diseases.
Centenarians are the primary representatives of this population.
During a 2008 study on pain and inflammation, an American team of pharmacological researchers discovered the PalGly molecule. Naturally present in the brain and skin, it exhibits anti-stress and anti-inflammatory properties, earning it its nickname, “the bliss molecule”!
SEPPIC, specialist in lipoamino acids, created a molecule identical to PalGly: TIMECODE™ (Palmitoyl Glycine). The objective was to offer the skin the biological secrets it needs for harmonious longevity.
TIMECODE™ is the first anti-inflamm’aging active cosmetic ingredient that affects the regulation of interleukin-6.
-39% interleukin-6 (Biological activity of aged fibroblasts treated with 0.001% of TIMECODE™ vs non treated aged fibroblasts)
- wrinkles + firmness + radiance
TIMECODE™& the inflamm’aging theory
Inflamm’aging
TIMECODE™
neutralizes
inflamm’aging
and targets
the key aging
markers
The skin’s
architecture is
strengthened
“Lifted”, and
fortified the skin
reveals a new
radiance!
1 Biological activity of aged fibroblasts in the presence of TIMECODE™ comparable to fibroblasts 15 years younger
Firmness
Gain up to 15 years1 of firmness!
-35%* Deep wrinkles1
Before treatment After 1 ½ months of treatment
Wrinkles are visibly smoothed over
78% of volunteers showed a visible effect
1½ months of treatment, TIMECODE™ is more efficient than the anti-aging benchmark
-33%* Medium wrinkles1
-20%* Total surface of wrinkles1
Protocol:• 42 days of treatment• Formula EU07143• Applied 2 times a day• 40 volunteers (average age: 56)• Quantification of various types of wrinkles Crow’s feet imprint conducted with a Silflo, measured by Quantirides® software• Comparison of TIMECODE™ (1%) with an anti-aging reference (3%) on the market: Glycerin & Butylene glycol & water & Carbomer & Polysorbate20 & Palmitoyl oligopeptides & Palmitoyl Tetrapeptide-7
In just 14 days
“Blooming skin” effect
Protocol:• 14 days of treatment• Formula at 1% of TIMECODE™ versus placebo• Applied to skin explant• Luminosity measurement (L*)• Skin redness measurement (a*)
* p<0.05 - 1Compared to the anti-aging active reference from the market
TIMECODE™ = dermis architect- Maintains and protects the extra-cellular matrix- Construction of the collagen network
TIMECODE™ defies the laws of gravity
For a luminous and rejuvenated complexion
Shadowy areas are blurred
Luminosity
Decrease in redness(Anti-inflamm’aging action)
-24%*
+5%*
Protocol:• Modeling of cells aging• Aged fibroblasts treated or not with 0.001% of TIMECODE™• Cosmetogenomic: highlighting the restoration of phenotype young of cells by TIMECODE™
* p<0.1
• Anti-inflamm’aging action
• Anti-wrinkles & firmness Construction of the collagen network
(a) Aged fibroblasts in the presence of 0.001% TIMECODE™ comparable to fibroblasts 15 years younger(b) Intra-cellular dosage on irradiated fibroblasts by UVA (10J/cm2) vs non irradiated fibroblasts(c) Interleukin-6: cytokine responsible for dermal inflammation(d) TIMP-2: natural inhibitor of metalloproteinases (collagenase…)(e) Tenascin-C: protein involved in the relationship between fibroblasts and collagens (contact, mobility…)(f) Dermatopontin: protein promoting collagen fibers organization
Control 0.00005% TIMECODE™
-39%(a)
• Anti-wrinkles & firmness Protection of the extra-cellular matrix
-100%*+29%*(b) TIMPS-2(d)
-15
years
TIM
ECODE
™ tu
rns
back
Anti-wrin
kles
Firmness
Radiance
Interleukin-6(c)
collagenase activity
+21%*(b) Pro-collagen-1
+194%(a) Tenascin C(e)
+124%(a) Dermatopontin(f)
• Radiance Improvement of the microvascular network
+18%***
Control the key aging markers
the sk
in’s
biol
ogica
l clo
ck
* p<0.05*** p<0.001
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Nota: The analytical specifications warranted are only those mentioned on the certificate of analysis supplied with each delivery of the product.Except as set forth above, SEPPIC* makes no warranties, whether express, implied or statutory, as to the product which is the subject of this document. Without limiting the generality of the foregoing, SEPPIC* makes no warranty of merchantability of the product or of the fitness of the product for any particular purpose. Buyer assumes all risk and liability resulting from the use or sale of the product, whether singly or in combination with other goods. The information set forth herein is furnished free of charge and is based on technical data that SEPPIC* believes to be reliable. It is intended for use by persons having technical skill and at their own discretion and risk. Since conditions of use are outside SEPPIC*’s control, SEPPIC* makes no warranties, express or implied, and assumes no liability in connection with any use of this information. Nothing herein is to be taken as a license to operate under or a recommendation to infringe any patents
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SEPPIC is a Subsidiary of the Air Liquide group within the Healthcare activity
© 2013 SEPPIC TIMECODE™ is registered as Trade Mark of SEPPIC
Air Liquide Healthcare is a world leader in medical gases, home healthcare, hygiene products and healthcare specialty ingredients. It aims to provide customers in the continuum of care from hospital to home with medical products, specialty ingredients and services that contribute to protecting vulnerable lives.
SEPPIC S.A.22 Terrasse BelliniParis La Défense92806 PUTEAUX cedex - FRANCETel.: + 33 (0) 1 42 91 40 [email protected]
Head Office75, quai d’Orsay75007 ParisFRANCE
SEPPIC Italia SrlITALIA Tel.: + 39 02 [email protected]
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SEPPIC Japan OfficeJAPANTel.: + 81 3 6414 [email protected]
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SEPPIC Inc.USATel.: + 1 973 882 [email protected]
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SEPPIC Colombia SASCOLOMBIATel.: + 571 702 44 [email protected]
SEPPIC MumbaiINDIATel.: + 91 22 [email protected]
SEPPIC ChinaCHINATel.: + 86 (21) 64 66 01 [email protected]
BiotechMarineFRANCETel.: + 33 (0)2 96 95 31 32 [email protected]
• INCI name: Palmitoyl Glycine• Pure active ingredient (white powder)• No preservatives• Usage dose: 1%• ECOCERT-approved• China: SFDA 2007• SEPPIC patent
LANOL™ PMONTANOV™ 202MONTANOV™ 82Vegetable squalanePolyisobuteneMONTANOX™ 60 DFKeltrol TTIMECODE™
Aqua/WaterChlorphenesinGlycerin
SEPIPLUS™ 400
SEPICIDE™ LDParfum/FragranceTEA 50%
YOUTH CreamFresh complexion (in vivo tested)
EU07143
1.50%2.00%1.00%7.00%
13.00%0.50%0.15%
1.00%
Qsp 100%0.30%5.00%
1.00%
0.70%0.10%0.15%
Immunofluorescence
Cosmetogenomic
Study on skin explants
Study on cells
Study in vivo
Aqua/WaterGlycerinSEPIMAX™ ZENDisodium EDTAChlorphenesinPhenoxyethanolEthylhexylglycerinSEPICONTROL™ A5
SEPIMAT™ SBMONTANOV™ LPolymethyl Methacrylate & Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer & IsohexadecaneSEPIMAT™ HB VTIMECODE™PROTEOL™ OATSEPIFEEL™ ONECyclopentasiloxane & Dimethicone / Vinyl Dimethicone Crosspolymer Tocopherol
Talc, Iron Oxides & Titanium oxide
Triethanolamine 10%AQUAXYL™
BB cream: mattifying youth foundation
EU07225
Qsp 100%3.00%
0.50%0.20%0.15%0.50%0.50%
1.00%
2.00%3.00%
3.50%1.00%1.00%1.50%1.00%
24.00%0.20%
8.18%
0.64%3.00%
Acellular study
