The 5th International Conference on Multi-Component ......16:50-17:10 Johan Van der Eycken, Ghent...

MCR2011

The 5th International Conference on Multi-Component Reactions and

Related Chemistry

Program and Abstracts

Department of Chemistry, Zhejiang University

Zhejiang Chemical Society

NOVEMBER 14-17, 2011

HANGZHOU, CHINA

CONTENTS

Committee I

Outline of the Program II

Program III

Abstracts 1

Author Index 60

I

The 5th International Conference on Multi-Component

Reactions and Related Chemistry

(MCR2011)

International Advisory Committee

Prof. Luca Banfi, University of Genova, Italy Prof. Alexander Dömling, University of Pittsburgh, USA Prof. Maxim A. Mironov, Ural State Technical University, Russia Prof. Thomas J. J. Müller, Heinrich-Heine-Universitaet Duesseldorf, Germany Prof. Romano Orru, Vrije University, Netherland Prof. Yanguang Wang, Zhejiang University, China Prof. Jieping Zhu, cole Polytechnique Fédérale de Lausanne, Switzerland

Organizing Committee

Chairman: Prof. Yanguang Wang, Zhejiang University, P. R. China

Co-Chairman: Prof. Jieping Zhu, cole Polytechnique Fédérale de Lausanne, Switzerland

Secretary: Prof. Ping Lu, Zhejiang University, P. R. China

Members: Prof. Wei-Min Dai, Hong Kong University of Science and Technology,

and Zhejiang University, P. R. China Prof. Xufeng Lin, Zhejiang University, P. R. China Prof. Cheng Ma, Zhejiang University, P. R. China Prof. Hongjun Ren, Zhejiang University, P. R. China Prof. Bingfeng Shi, Zhejiang University, P. R. China

II

Outline of the Program, MCR2011

15th, Time and Events 16th, Time and Events 8:30-8:50 Opening Remarks

8:30-9:00 Erik Van der Eycken

8:50-9:20 Zhengfeng Xi

9:00-9:25 Wenhao Hu

9:20-9:40 Irini Akritopoulou-Zanze

9:25-9:50 Hiroki Oguri

9:40-10:10 Jie Wu

9:50-10:10 Renata Riva

10:10-10:40 Coffee Break


10:40-11:10 Luca Banfi

10:40-11:10 Pengfei Xu

11:10-11:35 Weimin Dai

11:10-11:35 Michael G. Organ

11:35-12:00 Jared T. Shaw

11:35-12:00 Wei Zhang

12:00-13:30 Lunch

12:00-13:30 Lunch

13:30-14:00 Jieping Zhu

13:30-14:00 Thomas J. J. Müller

14:00-14:25 Maxim A. Mironov

14:00-14:25 Seung Bum Park

14:25-14:50 Cheng Ma

14:25-14:50 Chanjuan Xi

14:50-15:10 Andrea Basso

14:50-15:10 Fushun Liang

15:10-15:30 Thierry Constantieux

15:10-15:30 Xiaoxing Wu



16:00-16:30 Alexander Dömling

15:55-16:25 Romano Orru

16:30-16:50 Leonid G. Voskressensky

16:25-16:50 Gang Liu

16:50-17:10 Hongwei Zhou

16:50-17:10 Johan Van der Eycken

17:10-17:30 Ali Reza Kazemizadeh

17:10-17:30 Lei Yu

17:40-19:00 Dinner

17:30-17:50 Xufeng Lin

19:00-21:00 Poster Section

18:30-20:00 Banquet

III

Program

The 5th International Conference on Multi-Component

Reactions and Related Chemistry (MCR2011)

November 14-17, 2011

November 14, 2011 (Monday) 8:00-22:00 Registration The Lobby of Sunday Sunny Resort 18:30-20:00 Dinner (Buffet) Baihe Hall November 15, 2011(Tuesday) Location: Tianlang Hall

(8:30-8:50) 8:30-8:50 Opening remarks, Chairman, Prof. Yanguang Wang

Co-chairman, Prof. Jieping Zhu Chairperson: Yanguang Wang (8:50-10:10)

8:50--9:20 Zhenfeng Xi, Peking University Zirconocene-mediated 4- or 5-Component Coupling

9:20-9:40 Irini Akritopoulou-Zanze, Abbott Laboratories Applications of MCRs in Drug Discovery

9:40-10:10 Jie Wu, Fudan University Concise Approaches to H-Pyrazolo[5,1-a]isoquinolines


Chairperson: Jieping Zhu (10:40-12:00)10:40-11:10 Luca Banfi, University of Genova

Is the Ugi Reaction a Good Methjod for the Stereocontrolled Assembly of Peptidomimetics?

11:10-11:35 Wei-Min Dai, Hongkong University of Science and Technology Diverted Total Synthesis of Amphidinolide T1, T3 and T4

11:35-12:00 Jared T. Shaw, University of California, Davis Multicomponent Approaches to Organic Synthesis and Chemical Biology

12:00-13:30 Buffet, Baihe Hall Chairperson: Luca Banfi (13:30-16:00)

13:30-14:00 Jieping Zhu, Cole Polytechnique Fédérale de Lausanne Enantioselective Multicomponent Reactions

14:00-14:25 Maxim A. Mironov, Ural State Technical University Multi-Component Reactions at Interfaces: a Promising Technology for Organic Synthesis

14:25-14:50 Cheng Ma, Zhejiang University Ring-Transformation Reaction of Sulfur-Containing Heterocycles

IV

14:50-15:10 Andrea Basso, Università degli Studi di Genova Novel Heterocyclic Libraries from Passerini Adducts Derived from alpha-Azido Aldehydes

15:10-15:30 Thierry Constantieux, Aix-Marseille Université MCRs From 1,3-Dicarbonyls: Regioselective Synthesis of Highly Functionalized Pyridines

15:30-16:00

Coffee Break

Chairperson: Erik Van der Eycken (16:00-17:30)16:00-16:30 Alexander Dömling, University of Pittsburgh

How to Leverage the Very Large Chemical Space of Multi-Component Reactions?

16:30-16:50 Leonid G. Voskressensky, Russian Peoples Friendship University Azide Ugi-five-center-four-component reaction (U-5C-4CR) in the synthesis of tetrazolodiazepines. Scope and limitations

16:50-17:10 Hongwei Zhou, Zhejiang University A facile and efficient three-component domino reaction of 2-(1-alkynyl)-2-alken- 1-ones with gallium halide and anhydride to multifunctionalized tetra-substituted furans

17:10-17:30 Ali Reza Kazemizadeh, Zanjan Branch, Islamic Azad University One-Pot Synthesis of Tetrazole Derivatives by Ugi Three Component Reaction

17:40-19:00

Buffet, Baihe Hall

19:00-21:00 Poster section: Tianlang Hall November 16, 2011 (Wednesday)

Chairperson: Alexander Dömling (08:30-10:10)8:30-9:00 Erik Van der Eycken, Katholieke Universiteit Leuven

Micowaves and Multi-Component Reactions in the Synthesis of Medium-Sized Rings

9:00-9:25 Wenhao Hu, East China Normal University Novel Multi-Component Reactions Based on an Onium Ylide Trapping Process

9:25-9:50 Hiroki Oguri, Hokkaido University Concise Synthesis and Structural Diversification of Natural Product Analogues

9:50-10:10 Renata Riva, University of Genova A new diversity oriented synthesis of highly functionalized 3H-pyrimidin-4-ones

10:10-10:40

V

Coffee Break

Chairperson: Thomas J. J. Müller (10:40-12:00)10:40-11:10 Pengfei Xu, Lanzhou University

The Development and Application of Casade Reactions

11:10-11:35 Michael G. Organ, York University Multi-Step Synthesis Using a Flowed Chemical Platform

11:35-12:00 Wei Zhang, University of Massachusetts Boston Fluorous Multicomponent Reaction-based Diversity-Oriented Synthesis of Heterocyclic Scaffolds

12:00-13:30

Buffet, Baihe Hall

Chairperson: Romano Orru (13:30-15:55)

13:30-14:00 Thomas J. J. Müller, Heinrich-Heine-Universitaet Duesseldorf Sequentially Pd- and Pd-Cu-Catalyzed Processes in Multi-component and Domino Syntheses of Heterocycles

14:00-14:25 Seung Bum Park, Seoul National University Design Strategy of Drug-like Polyheterocycles with Privileged Substructures for Discovery of Specific Small Molecule Modulators

14:25-14:50 Chanjuan Xi, Tsinghua University Zirconium-Mediated Multicomponent Reactions

14:50-15:10 Fushun Liang, Northeast Normal University Multicomponent/Domino Reaction Starting from 1-Acetyl(cinnamoyl)- cyclopropanecarboxamides Towards Aza-/oxa-heterocycles

15:10-15:30 Xiaoxing Wu, Guangzhou Institutes of Biomedicine and Health Structure Revision and Total Synthesis of Berkelic Acid

15:30-15:55

Coffee Break

Chairperson: Wenhao Hu (15:55-17:30)15:55-16:25

Romano Orru, Vrije University Multicomponent reaction design in the quest for molecular complexity and diversity

16:25-16:50 Gang Liu, Tsinghua University A novel Dual Anti Tumor Agent: Inhibiting Tumor Growth anf Preventing from Tumor Metastasis

16:50-17:10 Johan Van der Eycken, Ghent University A Modular Approach to Chiral Imidates: A New Class of N-Based Chiral Ligands as Tools for Asymmetric Catalysis

17:10-17:30 Lei Yu, Yangzhou University Palladium-catalyzed Reaction of Olefins with PhI(OAc)2-TBAB System: An Efficient and Highly Selective Difunctional Strategy

VI

17:30-17:50 Xufeng Lin, Zhejiang University Multicomponent Reactions for the Rapid Synthesis of Diverse Bioactive Heterocycles

18:30-20:30

Banquet, Fangzhou Yuan

Novermber 17, 2011 (Thursday) Sightseeing: Leaving at 7:10 am and return at 18:00 Speakers: Please leave 5 minutes for discussion, the report time was strictly controlled by alarm clock. Meeting Location: Two-day meeting locates at Tianlang Hall, the first floor in the hotel. Food Location: Lunch and Dinner (Except the Banquet) will be served as Buffet at Baihe Hall of the first floor in the hotel. Banquet will be served at Fangzhou Yuan, the second floor in the hotel.

Poster Section: (19:00-21:00, November 15, 2011)

P01 Chao-Guo Yan, Yangzhou University

Multicomponent reactions based on isoquinolinium slats P02 Przhevalski Nikolai M, Russian State Agrarian University

A one-step multi-component synthesis of 2-(methylthio)furopyridopyrimidinones derivatives with potential biological activity

P03 Alexey V. Varlamov, Russian Peoples Friendship University Transformations of tetrahydrobenzothieno(furo)[2,3-c]pyridines under the action of activated alkynes

P04 Xin Li&Yong Rok Lee, Yeungnam University One-Pot Synthesis of Quinazoline-2,4-dione Derivatives and Their Application to Naturally Occurring Products

P05 Xiaoyan Zhu, Yeungnam University Efficient one-pot synthesis of 1-amidoalkyl-2-naphthols catalyzed by ruthenium(II)

P06 Julia A. Titova, I.Ya. Postovsky Institute of Organic Synthesis of RAS Effects of nanosized metal oxides on regio- and stereofeatures for the synthesis of dihydroazolopyrimidines

P07 Jian Li, Shanghai University Isocyanide-Based Three-Component Cycloaddition Reactions

P08 Renata Riva, Dipartimento di Chimica e Chimica Industriale A chemoenzymatic route to new chiral isocyanides and their use in highly diastereoselective Ugi reactions

P09 Jonghoon Kim, Seoul National University

VII

Solid-Phase Parallel Synthesis of Tetrahydroindazolone Library Containing Three Unique Core Skeletons

P10 Ja Young Koo, Seoul National University Discovery of ERRγ Inverse Agonist Eryvarin H and Its Structure Activity Relationship Study

P11 Heebum Song, Seoul National University Regioselective Construction of Enantiopure 1,3-disubstituted Tetrahydroindazolone Library for the Study of Stereochemical Diversity

P12 Hongjun Ren, Zhejiang University Lewis Acid-Promoted Synthesis of Unsymmetrical and Highly Functionalized Carbazoles and Dibenzofurans from Biaryl Triazenes: the Application for the Total Synthesis of Clausine C, Clausine R and Clauraila A

P13 Xiaopeng Chen, Zhejiang University Palladium-Catalyzed Cyclization of o-Haloacetophenone and Terminal Alkyne in Secondary Amine: Selective Synthesis of Functionalized Naphthalenes and Indenones and Their Luminescent Properties

P14 Yao Li, Zhejiang University One-pot synthesis of 5-sulfonamidopyrazoles from terminal alkynes, sulfonyl azides, and hydrozones

P15 Yang Shen, Zhejiang University Synthesis of Iminocoumarins, Quinazolinones and Isoquinolinones via Ketenimine Intermidiate

P16 Jing Wang, Zhejiang University Copper-Cascade Catalysis: Synthesis of 3-Functionalized Indoles

P17 Guangwei Yin, Zhejiang University The Application of Allenic Carbocation in Several Multi-components Reactions

P18 Yuanxun Zhu, Zhejiang University Tandem Reaction involving N-sulfonyl allenamide

P19 Ming Lei, Zhejiang University

P20 Jun Zhou, Zhejiang University 1,7-Palladium Migration via C-H Activation, Followedby Intramolecular Amination: Regioselective Synthesisof Benzotriazoles

P21 Zejun Jia, Zhejiang University Microwave-Assisted Oxo-IMDA Cycloaddition of Amide-Tethered 1,3,8-Nonatrienes

P22 Weiwei Han, Zhejiang University Microwave-Assisted Rap-Stoermer Reaction for Synthesis of Benzofurans

P23 Benguo Lin, Zhejiang University Microwave-Assisted IMDA Cycloaddition for Synthesis of Bicyclic -Pentyrolactones

The 5th International Conference on Multi-Component Reactions and Related Chemistry (MCR2011) Hangzhou 2011

(Applications of MCRs in drug discovery)

(Irini Akritopoulou-Zanze)

(Abbott Laboratories)

We report the implementation of multicomponent reactions to prepare novel and potent indazole kinase inhibitors. The

rationale behind this approach is the ability to rapidly explore the ATP binding site of numerous kinases, utilizing readily

available starting materials, without compromising the novelty of the final molecules. The compounds prepared were

evaluated against a panel of kinase assays and potent inhibitors were identified for Gsk3, Rock2 and Egfr.

NH

N

FG

NH

N

Het

New kinase inhibitorskinase hinge

MCRs

Figure 1. Design of novel molecules based on known kinase hinges

Reference

1 Akritopoulou-Zanze Irini; Wakefield Brian D; Gasiecki Alan; Kalvin Douglas; Johnson Eric F; Kovar Peter; Djuric Stevan W Scaffold oriented synthesis. Part 4: Design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions. Bioorg. Med. Chem. Lett., 2011, 21(5), 1480-1483

Dr. Irini Akritopoulou-Zanze received her B.Sc. degree in Chemistry from Aristotelian University of Thessaloniki, Greece. She then moved to the United States where she completed her Ph. D degree at University of Southern California, under the direction of Professor Nicos Petasis. Her doctoral work involved the discovery of new methodologies for the synthesis of alkenylsilanes via organotitanium reagents and allylamines via the Boronic Acid Mannich and also the synthesis of Lipoxin A and B analogs. Upon completion of a short post-doc assignment with Professor Petasis, she joined Professor Koji Nakanishi’s group at Columbia University for post-doctoral studies. At Koji’s group Irini was involved in the structural elucidation of natural products through synthetic and CD studies.

In 1997 Irini joined the Medicinal chemistry Technologies group at Abbott Laboratories where she is currently a senior group leader and a member of the Volwiler Society. Irini worked extensively on parallel synthesis and medicinal chemistry projects, on implementation of new technologies to pharmaceutical discovery and on enhancing the Abbott compound collection with proprietary diverse and /or targeted scaffolds and libraries of compounds. She is the author or co-author of more than 50 scientific publications and patents.

Fax: (+) ; 1-847-935-0310 E-mail: [email protected]

1


Novel heterocyclic libraries from Passerini adducts derived from a-azido aldehydes

Andrea Basso,a* Fabio De Moliner,a Stefano Crosignani,b Luca Banfia and Renata Rivaa

aUniversità degli Studi di Genova, Genova (I); bMerck Serono S. A., Geneva (CH). [email protected]

The Passerini three component reaction (P-3CR) followed by postcondensation modifications has been employed for the synthesis of libraries of pharmacologically relevant compounds based on original scaffolds.

In particular, -azidoaldehydes 1 have been considered as an innovative building block in the multicomponent step. Problems related to their intrinsic instability have been successfully overcome and the Passerini adducts 2 have been isolated in good yield. The azido group, inert during the condensation, is very versatile, and can undergo a number of useful transformations often providing access to heterocyclic products (Scheme 1). Among the most common ones, the Staudinger Aza-Wittig reaction and the 1,3 dipolar cycloaddition with alkynes will be the matter of this presentation.

Microwave assisted reactions, polymer supported reagents and straightforward purifications have been efficiently employed to generate library formats.

N3

R1

1

N3

R1

2O

NH

OR3

R2

O

N

O

O

NH

R3

R1

R2

O R2 CO2H R3 NCP-3CR

N

R1

NH

O

R3N

N

R4

O

O

post-condensationtransformations

Scheme 1.

References

1 De Moliner, F.; Crosignani, S.; Banfi, L.; Riva, R.; Basso, A. J. Comb. Chem. 2010, 12, 613.

2 De Moliner, F.; Crosignani, S.; Galatini, A.; Riva, R.; Basso, A. ACS Comb. Sci. 2011, in press.

2


Palladium-Catalyzed Cyclization of o-Haloacetophenone and Terminal Alkyne in Secondary Amine

Xiaopeng Chen, Jisong Jin, Ningning Wang, Ping Lu* and Yanguang Wang*

Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China

Selective synthesis of functionalized　naphthalenes and indenones via a palladium-catalyzed cyclization of o-haloacetophenone and terminal alkyne in secondary amine is reported. Under the nitrogen atmosphere, palladium-catalyzed reaction of o-haloacetophenones with terminal alkynes and wet secondary amines generated 1-(N,N-dialkylamino) -3- aryl/alkylnaphthalenes. When the reaction was conducted under air atmosphere, 1-indenone-3-carbaldehydes were obtained. The synthesized -arylnaphthalenes emitted light in a range from 386 nm to 452 nm with quantum yields from 0.10 to 0.48 in cyclohexane. Absorption and emission efficiency of 4d could be finely tuned by environmental acidity and might be useful as a fluorescent pH sensor.

Scheme 1. Palladium-catalyzed multicomponent reaction of o-haloacetophenones, terminal alkynes and secondary amines under different condition

200 250 300 350 400

0.0

0.1

0.2

0.3

0.4

0.5

Inte

nsi

ty/a

.u.

Wavelength/nm

6.48 6.01 5.68 5.14 4.76 4.22 3.89 3.44 3.00 2.56 2.20 1.86 1.50 1.12 0.81

pH=(a)

350 400 450 500 550 600 6500

100

200

300

400

500

600

700

Inte

nsi

ty/a

.u.

Wavelength/nm

6.48 6.01 5.68 5.14 4.76 4.22 3.89 3.44 3.00 2.56 2.20 1.86 1.50 1.12 0.81

pH=

(b)

Figure 1. Absorption (a) and emission (b) spectra of 4d at variable acidity (λex = 325nm)

Reference

(a) P. Belmont, T. Belhadj, Org. Lett. 2005, 7, 1793; (b) M. Tiano, P. Belmont, J. Org. Chem. 2008, 73, 4101;

(c) X. Chen, J. Jin, N. Wang, P. Lu, Y. Wang, Eur. J. Org. Chem. 2011, accepted.

2003-2007: B.S. (Chemistry), Zhejiang University, Hangzhou, China

2007-present: Ph.D. (Organic Chemistry), Zhejiang University, Hangzhou, China

Fax: (+) 86-571-87951978 E-mail: [email protected]

3


MCRs FROM 1,3-DICARBONYLS: REGIOSELECTIVE SYNTHESIS OF HIGHLY FUNCTIONALIZED PYRIDINES

Christophe Allais, Jean Rodriguez and Thierry Constantieux*

Aix-Marseille Université – CNRS UMR 6263 iSm2 - Centre Saint Jérôme - service 531 - 13397 MARSEILLE Cedex 20 – France

At the moment, the ecological situation of our planet is becoming worrisome and the organic chemists have to go into an "eco-conception" era of molecules, while remaining capable of furnishing products of high molecular complexity. Among the various methods developed for that purpose, multicomponent reactions1 involving domino processes answer perfectly these constraints. In this context, our Group is interested for several years in the synthesis of new heterocyclic molecules with the aim of using them as building blocks for the development of new leads in the pharmaceutical industry. Thus we developed new Michael addition-initiated domino multicomponent reactions2 involving a 1,3-dicarbonyl compound,3 a Michael acceptor and various amines. This sequence allowed the rapid access to highly substituted pyridines when the amine is replaced by an ammonia source: ammonium acetate (Scheme 1).4 With appropriate starting materials, this sequence allows the formation of various pyridine derivatives such as 4-azafluorenones, nicotinamides, bi-pyridines or fluorinated pyridines. A wide panel of substituents can be easily introduced on the pyridine moiety in a totally regioselective manner (Figure 1).

Scheme 1. General scheme for the totally regioselective three-component synthesis of pyridines

Figure 1. Functional diversity on the pyridine nucleus

References

1 a) Multicomponent Reactions, Zhu, J.; Bienaymé, H.; Eds., Wiley-VCH: Weinheim, 2005 ; b) Ramon, D. J.; Yus, M.; Angew. Chem., Int. Ed. 2005, 44, 1602 ; c) Dömling, A.; Chem. Rev. 2006, 106, 17.

2 Liéby-Muller, F.; Simon, C.; Constantieux, T.; Rodriguez, J. QSAR Comb. Sci. 2006, 25, 432.

3 a) Simon, C.; Constantieux, T.; Rodriguez, J. Eur. J. Org. Chem. 2004, 4957 ; b) Sanchez Duque, M.M.; Allais, C.; Isambert, N.; Constantieux, T.; Rodriguez J. Top. Heterocyclic Chem. 2010, 23, 227. c) Bonne, D.; Coquerel, Y.; Constantieux, T.; Rodriguez, J. Tetrahedron: Asym. 2010, 21, 1085.

4 a) Liéby-Muller, F. ; Allais, C. ; Constantieux, T.; Rodriguez, J.; Chem. Commun. 2008, 4207 ; b) Allais, C.; Constantieux, T.; Rodriguez, J. Chem Eur. J. 2009, 12945.

Thierry Constantieux was born in Pau, France, in 1968. After studying chemistry at University Bordeaux I, he completed his PhD under the supervision of Dr. J-P. Picard in 1994. He completed his Habilitation in 2004, at Université Paul Cézanne, where he is currently Full Professor of Organic Chemistry. His main research interest is focused on the development of new eco-compatible synthetic methodologies, especially domino MCRs from 1,3-dicarbonyl compouds, and their applications in heterocyclic chemistry.

Fax: (+) 33-(0)491-289-187; E-mail: [email protected] Homepage : http://www.ism2.univ-cezanne.fr/permanents/CONSTANTIEUX.php

4


Diverted Total Synthesis of Amphidinolide T1, T3 and T4

Wei-Min Dai*

Laboratory of Asymmetric Catalysis and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, China and Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China

Diverted total synthesis (DTS)1a has emerged as a powerful tool for accessing analogues of natural products with considerable structural complexity and it plays an invaluable role in probing the function (or biology) of natural products. In parallel, DTS can be devised for synthesis of a collection of naturally occurring compounds, i.e. the library of natural products that share similar molecular skeletons, stereochemistry, and/or functionalities to a great extent. The amphidinolide series of marine macrolides serves as the excellent case studies.1b In this presentation, our strategy toward DTS of amphidinolide T series macrolides, i.e. T1, T3, and T4 (1, 3, and 4 in Figure 1), is discussed.2 An advanced 19-membered ring (12E)-cycloalkene 6, obtained via ring-closing metathesis (RCM), serves as the common intermediate. It was selectively converted into the diols 7 and 8 via asymmetric dihydroxylation (AD). The diols were then transformed into the targeted -hydroxy ketones 1, 3–5, respectively, through selective monosilylation–DMP oxidation–desilylation.

O

OHO Me

CH2

O

O

MeMe

2: amphidinolide T2

12R 1413

21S 22

O

OHO Me

CH2

O

O

MeMe

Me

12S 1413

4: amphidinolide T4

Me

OHO

Me

CH2

O

O

Me

Me

12

13

14

1618

78

10

2

MeO

OHHO Me

CH2

O

O

MeMe

Me

12S 1413S

O

OHO Me

CH2

O

O

MeMe

Me

12 1413S

1: amphidinolide T1

7: (12S,13S)-diol

RCM

esterformation

6

O

OHHO Me

CH2

O

O

MeMe

Me

12R 1413R

8: (12R,13R)-diol

ADAD

O

OHO Me

CH2

O

O

MeMe

Me

12R 1413

3: amphidinolide T3

O

OHO Me

CH2

O

O

MeMe

Me

12 1413R

5: 13-epi-amphidinolide T1

Figure 1. Strategy for diverted total synthesis of amphidinolide T1 (1), T3 (3) and T4 (4) from a common advanced (12E)-cycloalkene 6.

References

1. For reviews, see: (a) Szpilman, A. M.; Carreira, E. M. Angew. Chem. Int. Ed. 2010, 49, 9592–9628. (b) Fürstner, A. Isr. J. Chem. 2011, 51, 329–345.

2 (a) Luo, J.; Li, H.; Wu, J.; Xing, X.; Dai, W.-M. Tetrahedron 2009, 65, 6828–6833. (b) Li, H.; Wu, J.; Luo, J.; Dai, W.-M. Chem. Eur. J. 2010, 16, 11530–11534. (c) Wu, D.; Li, H.; Jin, J.; Wu, J.; Dai, W.-M. Synlett 2011, 895–898. (d) Sun, L.; Wu, D.; Wu, J.; Dai, W.-M. unpublished resilts.

Wei-Min Dai, Ph.D.

B.Sc., 1978–1982, Hangzhou University, China

M.Sc., 1982–1984, Shanghai Institute of Organic Chemistry, The Chinese Academy of Sciences

Ph.D., 1985–1990, Kyoto University, Japan

Postdoc., 1990–1992, The Scripps Research Institute, La Jolla, USA

Professor of Chemistry, 1992–present, The Hong Kong University of Science and Technology

Fax: (+)852-23581594; E-mail: [email protected] Homepage: http://ihome.ust.hk/~chdai/wmdai.html

5


How to leverage the very large chemical space of multicomponent reactions?

Alexander Dömling*

Universities of Groningen and Pittsburgh, The Netherlands and USA

The synthetic advantages of multicomponent reactions (MCRs) are highly appreciated in pharmaceutical, agrochemical and other industries. An increasing number of products based on MCRs are marketed or in development. Recent examples include boceprivir, retosiban or mandipropamide, just to name a few.1

A key feature of MCR chemistry is the very large chemical space which is amenable to discover useful compounds to advance human mankind. In fact it can be estimated that the breath of the MCR chemical space is easily approaching 1020. Synthetic technologies, however cannot efficiently leverage this huge chemical space and only a very minor fraction of the MCR space can be realistically synthesized. Thus the question arises “How to leverage the very large chemical space of multicomponent reactions”.

Here we will discuss pros and cons of different approaches to discover useful compounds from the MCR universe, including combinatorial chemistry, targeted (library) approaches, computational similarity searches, computational docking and the recently introduced ANCHOR approach (Fig.1).2

Figure 1. The ANCHOR approach towards small molecule protein protein antagonists allows to screen a very large MCR-based chemical space including multiple scaffolds and results in synthesizable and easily to confirm hits in just seconds. The interactive software tool is is freely available at: http://anchorquery.ccbb.pitt.edu/

Reference

1 A. Dömling, W. Wang, K. Wang Chemistry & Biology of Multicomponent Recations Chem. Rev. 2011 in press.

2 A. Czarna et al. Robust Generation of Lead Compounds for Protein–Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists Angew. Chem. 2010, 49, 5352.

3 D. Koes et al. Enabling large-scale design, synthesis and validation of small molecule protein-protein Antagonists PLoS Computational Biology 2011, in press.

6

Alexander Dömling

Alexander Dömling (borne 1964) studied Chemistry & Biology at the Technical University Munich (TUM). He performed his PhD under the surveillance of the late Ivar Ugi working on the “Seven Component Reaction”. As a Feodor Lynen Fellow of the Alexander von Humboldt foundation he performed his postdoc in the laboratory of the Nobel laureate Barry Sharpless working on novel multicomponent reactions (MCRs) of hydrazines, epoxides and carboxylic acid derivatives. In 1996 he started the biotech company Morphochem and served as vice president chemistry and board member till 2004. During this time several drug candidates have been discovered at Morphochem and are currently in late preclinical or clinical trials. In 2003 he performed the Habilitation at the TUM and received the “Lehrerlaubniss in Chemie”. Since 2004 he is faculty member at the TUM. In 2006 he accepted an professor position in the School of Pharmacy (Drug Discovery Institute) at the University of Pittsburgh with secondary appointments in the department of chemistry and computational and systems biology. Recently he accepted a position as chair for drug design at the University of Groningen, The Netherlands. His research interest are centred around MCRs, including new MCR, stereoselective MCRs, chemoinformatic of MCRs and its applications to medicinal and combinatorial chemistry. Specifically, he is interested in the rational design protein protein interactions (ant)agonists, protease inhibitors and drugs for neglected tropical diseases (NTD). His therapeutic interests include cancer, NTD, COPD, diabetes and infectious diseases. He is offering his expertise in MCR chemistry to pharma and agro companies and to Universities by performing in-house short courses.

Fax: (+) 412-383-5298 ; E-mail: [email protected] ; [email protected] Homepage: http://www.wix.com/adoemling/dmling-laboratories-seicht-gru

7


Novel multi-component reactions based on an onium ylide trapping process

Jun Jiang, Xinfang Xu, Xiaoyu Guan, Xia Zhang, Jin Zhou, Huadong Xu and Wenhao Hu*

Department of Chemistry, East China Normal University, Shanghai 200062, China

((Main Text Paragraph)) Multicomponent reactions have received considerable attention because of their inherent advantages in

the formation of multiple chemical bonds from three or more simple starting materials in one operation.1

Irreversible trapping of an active intermediate resulting from two components by a third component is an effective strategy for the discovery of novel multicomponent reactions.2 However, control of the reaction selectivity, including chemoselectivity, diastereoselectivity, and enantioselectivity, is very challenging, especially when the active intermediate itself has other side transformation pathways. Dual /cooperative catalysis strategy provides an opportunity for controlling the reaction selectivity in the multicomponent reactions. This concept is demonstrated in the reaction of an onium ylide trapping process. Protic onium ylides, derived from a carbenoid and an alcohol or an amine, have been proposed as active intermediates for O–H or N–H insertion in transition-metal-catalyzed decomposition of diazo compounds. This class of ylides with acidic protons and basic carbanions in vicinal proximity are of high energy and were formerly thought to be too reactive to be intercepted by external electrophiles. This assumption has been changing, based on strong evidences in our laboratory that these protic onium ylides can be trapped by active electrophile to provide rapid and efficient access to polyfunctional molecules, and the application of cooperative catalysis strategy gives the multi-component products in good yield with high level control of stereoselectivity (Scheme 1).

RR'

XR''H

MLn

RR'

XR'' H

RR'

XR'' H

MLn

RR'

MLn

X HR''

:

Onium ylide

RR'

XR''

H

Electrophile

Co-catalyst

X-H insertion

ElectrophileElectrophile

Protontransfer

"Delayedprotontransfer"

RR'

N2

+R''XH

(X= O, NH)

Electrophile

Ylide trapping

Scheme 1. Trapping of an onium ylide by an electrophile.

Reference

1 Zhu, J., Bienayme, H. & Editors. Multicomponent Reactions. (WILEY-VCH Verlag GmbH & Co. KGaA, 2005).

2 Nair, V.; Rajesh, C.; Vinod, A. U.; Bindu,. S.; Sreekanth, A. R.; Mathen, J. S.; Balagopal, L. Acc. Chem. Res. 2003, 36, 899-907.

Wenhao Hu, b 1967 in China. Sichuan University (B 1987), Chengdu Institute of Organic Chemistry (M 1990), The Hong Kong Polytechnic University (PhD 1998, Prof. A.S.C.Chan), Postdoc. Univ. of Arizona, AZ, USA (Prof. M. P. Doyle, 1998-2002), Staff Scientist (GeneSoft Pharm. Inc. CA, USA, 2002-2003), Research Investigator (Bristo-Myers Squibb, NJ, USA, 2003-2006), Prof. ECNU (2006-present). Research filed: organic chemistry, process chemistry, synthetic methodology, multi-component reactions, and asymmetric catalysis.

Fax: (+) ;86-21-62601893-ext8036 E-mail: [email protected] Homepage ((optional)):

8


One-Pot Synthesis of Tetrazole Derivatives by Ugi Three Component Reaction

Ali Reza Kazemizadeh*1, Nasrin Hajaliakbari2, Roghayeh Hajian2

1Research Laboratory of MCRs, Department of Chemistry, Zanjan Branch, Islamic Azad University, P O Box 49195-467, Zanjan, Iran

2Department of Chemistry, Payame Noor University, Zanjan, Iran

[email protected]

Nowadays many organic compounds can be synthesized by multicomponent reactions (MCR). Isocyanide-based multicomponent reactions (IMCR) are particularly interesting because they are more versatile and diverse than the remaining MCR1-3. Today most IMCR chemistry relates to the classical reactions of Passerini and Ugi. In connection with our recent interest to isocyanide chemistry4, we report the three component Ugi reaction of isocyanides (1), carbodiimides (2), and trimethylsilyl azide (3). The reaction proceeds at room temperature and tetrazole derivatives (4) are synthesized in excellent yields. The structures of the products were confirmed from their IR, 1H NMR, 13C NMR spectra, mass spectroscopy and elemental analyses.

R'NC +MeOH

r.t., 24 hrs.

NR"

R"N C NR" + TMSN3

R"HN

N

NN

N

R'

Scheme 1. Synthesis of 1H-tetrazole-5-carboxamidine derivatives (4).

(1) (2) (3) (4)

References

1 Zhu, J. Multicomponent Reactions, WILEY-VCH: Weinheim, 2005.

2 Dömling, A. Chem. Rev., 2006, 106, 17.

3 a) Sadjadi, S.; Heravi, M.M. Tetrahedron, 2011, 67, 2707. b) Shaabani, A; Maleki, A; Rezayan, A.H.; Sarvary, A. Mol. Divers., 2011, 15, 41.

4 a) Kazemizadeh, A.R.; Ramazani, A. Arkivoc, 2008, xv, 159. b) Kazemizadeh, A.R.; Ramazani, A. J. Braz. Chem. Soc., 2009, 20, 309. c) Shoaei, S.M.; Kazemizadeh, A.R.; Ramazani, A. Chinese J. Struct. Chem., 2011, 30, 568.

Name: Ali Reza

Surename: Kazemizadeh

Date of Birth: 1970/05/01

Nationality: Iranian

Academic Degree: Bsc. 1991-1995, Chemistry, Zanjan University, Iran; Msc. 1996-1999, Organic Chemistry, Tabriz University, Iran; PhD. 2005-2009, Organic Chemistry, Zanjan University, Iran

Academic Position: Assistant professor of Chemistry Department, Zanjan Branch, Islamic Azad University, Zanjan, Iran

Fax: (+) ; 00982414261221 E-mail: [email protected] Homepage: http://azu.iau.ofis.ir/default.aspx?general&member=3348

9

http://azu.iau.ofis.ir/default.aspx?departments&department=1330�

mailto:[email protected]

mailto:[email protected]


Solid-Phase Parallel Synthesis of Tetrahydroindazolone Library Containing Three

Unique Core Skeletons

Jonghoon Kim, Heebum Song, Seung Bum Park*

†Department of Chemistry and ‡Department of Biophysics and Chemical Biology, Seoul National University, Seoul 151-747, Korea

The efficient synthesis of privileged heterocycles is a crucial issue in diversity oriented synthesis (DOS),

combinatorial chemistry, and medicinal chemistry, because many natural compounds and small molecules

containing heterocyclic units have been identified as potential drug candidates with a wide range of biological

activities. Indazole and indazolone are prominent heterocycles that show various biological activities such as anti-

inflammatory, antiviral, and anticancer activities. In particular, SNX-2122, which contains a tetrahydroindazolone

moiety, has been identified as a potent heat shock protein 90 (HSP90) inhibitor and exhibits low nanomolar

antiproliferative activities against multiple cancer cell lines. SNX-2122 is currently in phase III clinical trials. In

spite of their proven importance in biomedical research, the systematic exploration of chemical space around

privilegd tetrahydroindazolones has not yet been extensively pursued. Furthermore, we were interested in the

diversification of tetrahydroindazolone-based core skeletons with the preservation of its validated molecular

frameworks. Therefore, we developed a practical procedure for the synthesis of tetrahydroindazolone with

excellent regioselectivity and accomplished the construction of a novel tetrahydroindazolone library containing

three unique core skeletons using solid-phase parallel synthesis. The condensation of in-situ generated

arylhydrazine on solid supports with 2-acylcyclohexane-1,3-diones ensured the efficiency of solid-phase parallel

synthesis. In addition, we introduced three unique core skeletons containing nitrophenyl, anilyl, and pyridyl groups

to maximize the molecular diversity through diverse display of polar surface area in 3-D chemical space. A 162-

member drug-like tetrahydroindazolone library was constructed in the average purity of 92% without further

purification

10


Discovery of ERRγ Inverse Agonist Eryvarin H and Its Structure Activity

Relationship Study

Ja Young Koo1, Sangmi Oh1, Minseob Koh1 and Seung Bum Park1, 2 1Department of Chemistry and 2Department of Biophysics and Chemical Biology, College of Natural Science,

Seoul National University, Seoul 151-747, Korea

Nuclear receptors are one of the important targets for various intracellular functions via regulating gene transcription.

Orphan nuclear receptor has no identified ligands while it has similar structure with other identified receptors. Estrogen

related receptor gamma (ERRγ) is a third subtype receptor of ERRs and one of the orphan receptors. ERRγ has various

biological functions, which have been reported such as oxidative metabolism, suppressing cell proliferation and tumor

growth of prostate cancer cells, and modulating cell proliferation and estrogen signaling in breast cancer. We found a

inverse agonist, Eryvarin H, of ERRγ from a number of natural compounds based on docking simulation. Eryvarin H is a

known natural compound, which is one of the Eryvarin series isolated from the roots of plant Erythrina variegata. Then

we synthesized Eryvarin H and its derivatives by our own methods via Suzuki-Miyaura cross-coupling reaction. Change

of aryl groups by using different kinds of boronic acids gave us 12 different Eryvarin H derivatives. After synthesis of

those compounds, we analyzed their inverse agonistic effect by using Gal4-fused ERRγ LBD system embedded on dual-

luciferase gene assay. We discovered not only Eryvarin H but also its derivatives are inverse agonists of ERRγ with

comparable activity. Moreover, we could analyze the structure activity relationship (SAR) pattern from the structural

informations of 12 derivatives and their cell-based assay data. From this research, which is a natural compound based

SAR approach assisted by protein-ligand docking, we can conclude that this work is a quite useful way to discover lead

compounds for modulating selected target.

11

1


One-Pot Synthesis of Quinazoline-2,4-dione Derivatives and Their Application to Naturally Occurring Products

Xin Li, and Yong Rok Lee*

School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, Korea

We describe herein a one-pot synthesis of quinazoline-2,4-dione derivatives starting from isatoic anhydride, primary amines, and triphosgene in the presence of K2CO3. As an application of this methodology, we also describe herein an efficient and concise synthesis of biologically active goshuyuamide II (1), wuchuyuamide II (2), 3, and 4.

NH

N

O

O

R

NH

O

O

O K2CO3

THF

then triphogene

RNH2

Scheme 1

N

N

O

O

NH

1

goshuyuamide II

N

N

O

O

R

3 R=H4 R=OCH3

N

N

O

O

NHO

2

wuchuyuamide II

Figure 1. Naturally occurring products with quinazolinedione nuclei

Reference

Undheim, K.; Benneche, T. In Comprehensive Heterocyclic Chemistry II; Katritzky, A. R.; Rees, C. W.; Scriven, E. F. V., Eds.Elsevier: Oxford, UK, 1996; Vol. 6, p 93. Ismail, M. A. H.; Barker, S.; El Ella, D. A. A.; Abouzid, K. A. M.; Toubar, R. A.; Todd, M. H. J. Med. Chem. 2006, 49, 1526.Goto, S.; Tsuboi, H.; Kagara, K. Chem. Express 1993, 8, 761. Liu, J.; Birzin, E. T.; Chan, W.; Yang, Y. T.; Lee, Y. P.; DaSilva, C.; Hayes, E. C.; Mosley, R. T.; DiNinno, F.; Rohrer, S. P.; Schaeffer, J. M.; Hammond, M. L. Bioorg. Med. Chem. Lett. 2005, 15, 751. Hayao, S.; Havera, H. J.; Strycker, W. G.; Leipzig, T. J.; Kulp, R. A.; Hartzler, H. E. J. Med. Chem. 1965, 8, 807. (a) Leysen, J. E.; Niemegeers, C. J. E.; Van Neuten, J. M.; Lauuron, P. M. Mol. Pharmacol. 1982, 21, 301. (b) Darchen, F.; Scherman, D.; Laduron, P. M.; Henry, J. P. Mol. Pharmacol. 1988, 33, 672. Jin, H.-Z.; Du, J.-L.; Zhang, W.-D.; Chen, H.-S.; Lee, J.-H.; Lee, J.-J. J. Asian Nat. Prod. Res. 2007, 9, 685.

1. Undergraduate (1978-1982) : B.S. Department of Chemistry, Chonbuk National University (Korea)

2. Graduate (1982-1984) : M.S. Department of Chemistry, Seoul National University (Korea)

3. Graduate (1989-1992) : Ph. D. Department of Chemistry, Seoul National University (Korea)

Fax: (+) 82-053- 810-4631 ; E-mail: [email protected] Homepage ((optional)):

12


One-pot, three-component synthesis of highly functionalized 1,3-oxazine derivatives via 1,4-dipolar cycloadditions

Ming Lei,* Zujin Zhan, Wan Tian, Ping Lu, Yanguang Wang

(Department of Chemistry, Zhejiang University, Hangzhou 310027, China)

The formation of a 1,4-dipole from isoquinoline and dimethyl acetylenedicarboxylate (DMAD) and its trapping by phenyl isocyanate, diethyl mesoxalate, and dimethyl azodicarboxylate had been reported by Huisgen for more than three dacade years.1 In 2002, Nair demonstrated that the Huisgen 1,4-dipole derived from isoquinoline and dimethyl acetylenedicarboxylate (DMAD)8 could readily react with N-tosylimines resulting in the diastereoselective synthesis of isoquinoline derivatives via 1,4-dipolar cycloaddition.2a Then several groups expanded the method using other dipolarphiles.2b-2d However, few nucleophilic species such as isoquinoline, quinoline and pyridine were employed to generate 1,4-dipoles and the products are limited within isoquinoline derivatives. It is noteworthy that all of the above nucleophilic species contain α, β-unsaturated imine or imine scaffold (Figure 1). Therefore, we envisioned that imine could generate 1,4-dipoles and initiate an [4+2] annulation with dipolarophiles. As a part of our program aiming at new approaches to diverse heterocycles,3 we developed a convenient method for the synthesis of highly functionalized 1,3-oxazine derivatives via one-pot three-component reaction (Scheme 1). Moreover, the expected 1,3-oxazine derivatives are attractive compounds for drug discovery.

N

N

N

NN

N

CH3CN

RT or heat+

N

O

R4

R4

R1

R2

R1

R2

R3

R3

R5

R4

R4

HO

R5

+

18 examples 42~97% yields

H

H

N

O

R4

R4

R1

R2

R3

R5

H

H

+

Figure 1. Scheme 1. Synthesis of 1,3-oxazine derivatives via one-pot three conponent reaction

Reference

1 Huisgen, R.; Morikawa, M.; Herbig, K.; Brunn, E. Chem. Ber. 1967, 100, 1094.

2 (a) Nair, V.; Sreekanth, A. R.; Abhilash, N; Bhadbhade, M. M.; Gonnade, R. C. Org. Lett. 2002, 4, 3575; (b) Esmaeili, A. A. Nazer, M. Synlett, 2009, 2119; (c) Arizadeh, A.; Zohreh, N. Synthesis, 2008, 3, 429; (d) Terzidis, M. A.; Troleridis, C. A.; Stephanitou-stephanatou, J. Synlett, 2009, 229; (e) haabani, A.; Rezayan, A. H.; Sarvary, A.; Heidary, M.; Ng, S. W. Tetrahedron 2009, 65, 6063; (f) Yavari, I.; Mirzaei, A.; Moradi, L.; Khalili, G. Tetrahedron Lett. 2010, 51, 396; (g) Teimouri, M. B.; Abbasi, T.; Ahmadian, S.; Heravi, M. R. P.; Bazhrang, R. Tetrahedron 2009, 65, 8120;

3 (a) Hong, D.; Lin X. F.; Zhu, Y. X.; Lei, M.; Wang, Y. G. Org. Lett. 2009, 11, 3678; (b) Lei, M.; Song, W. Z.; Zhan, Z. J.; Cui, S. L.; Zhong, F. R. Lett. Org. Chem. 2011, 8, 163; (c) Tao, X. L.; Lei, M.; Wang, Y. G. Synthetic Commun. 2007, 37, 399.

Ming Lei, Zhejiang University (Ph. D. 2002), Postdoctoral research at Zhejiang University & Hisun Pharmarceutical Corporation. In 2004, he joined the Department of Chemistry in Zhejiang University as associate professor. His research is mainly focus on design, synthesis and application of functional molecule base on structure-function relationship such as multicomponent reactions, design and synthesis of PET imaging agents, synthesis of biologically active heteocycle compounds, medicine chemistry and polymorphic drug and quality control.

Tel: (+) 86-571-87952359 Fax: (+) 86-571-87951895 E-mail: [email protected] Homepage: http://mypage.zju.edu.cn/leiming

13


Three-Component [2+2+1] Cycloaddition to Synthesize Spirocyclic Oxindole-Butenolides

Jian Li,* Yuejin Liu, Chunju Li and Xueshun Jia*

Department of Chemistry, Shanghai University, 99 Shangda Road, Shanghai, 200444, P. R. China

Spirocyclic oxindoles are important synthetic targets due to their common occurence in natural products and clinical pharmaceuticals.[1] Consequently, much efforts have been made towards their Syntheses. However, method to effciently construct this core structure in a chemo-, regio- and stereocontrolled manner is still of high demand.

N

NH

O

O

MeMe

O

NOMe

HMe Me

HO

Me

paraherquamide A

Figure 1. Representative natural product possessing spiro-oxindole core

The phosphine-catalyzed [3+2] cycloaddition of allenoates with electron-deficient species such as olefins and imines have been fully investigated, thereby providing new pathways to functionalized five-membered carbo- and heterocycles.[2] Herein we wish to report a novel multicomponent reaction based on the above [3+2] annulation (Scheme 1).[3] This protocol provides a new opportunity to synthesize functionalized spirocyclic oxindole-butenolides from simple and readily available starting materials in an efficient and atom-economical manner.

NPG

O

OCO2Et

R1N

NPG

O

O+toluene

100 oCNR1

CCO2Et

+ R2R2

up to 91 % yieldR1 = alkyl, aryl R2 = halide, methoxy, nitro

Scheme 1. Syntheses of spirocyclic oxindoles

Reference

1 a) C. Marti, E. M. Carreira, Eur. J. Org. Chem. 2003, 2209-2219; b) R. M. Williams, R. J. Cox, Acc. Chem. Res. 2003, 36, 127-139.

2 X. Lu, C. Zhang, Z. Xu, Acc. Chem. Res. 2001, 34, 535-544.

3 J. Li, Y. J. Liu, C. J. Li, X. S. Jia, Chem. Eur. J. 2011, 17, 7409-7413.

Jian Li was born in Weifang, Shandong Province. He obtained his B.S. degree from China Petroleum University. After he received the Ph. D. degree from Zhejiang University in 2006, he started to work in Shanghai University as an assistant professor. And he was promoted to associate professor in 2009.

Fax: (+) 86-21-66134862 ; E-mail: [email protected]

14

O

Weandcon

Re

1.

2.

3. 4.

5. 6.

7.

The 5R

One-PotThe

e describe herd triphosgene ncise synthesi

eference

Undheim, KEds.; ElsevIsmail, M. 1526. Goto, S.; TLiu, J.; BirzP.; SchaeffHayao, S.; (a) Leysen,F.; SchermJin, H.-Z.; D

5th InternatReactions a

t Syntheir App

Sch

rein a one-potin the presen

is of biologica

N

N

O

goshuyuam

F

K.; Benneche,vier: Oxford, UA. H.; Barker

Tsuboi, H.; Kazin, E. T.; Cha

fer, J. M.; HamHavera, H. J.;, J. E.; Nieme

man, D.; LaduroDu, J.-L.; Zha

tional Confand Related

hesis ofplicatio

hool of Chemica

t synthesis of nce of K2CO3

ally active gos

O

NH

1

mide II

Figure 1. Nat

, T. In ComprUK, 1996; Vor, S.; El Ella,

agara, K. Cheman, W.; Yang,

mmond, M. L.; Strycker, W.

egeers, C. J. Eon, P. M.; Henang, W.-D.; C

1.

2.

3.

ference ond Chemistr

f Quinon to N

Xin Li, a

al Engineering, Y

f quinazoline-2

3. As an applishuyuamide II

NH

O

O

Ot

wuc

turally occurri

rehensive Hetel. 6, p 93. D. A. A.; Abo

m. Express 199, Y. T.; Lee, Y Bioorg. Med. G.; Leipzig,

E.; Van Neutennry, J. P. Mol.hen, H.-S.; Le

2000-2004 B.

2006-2008 M.

2008-2011 Ph

Fax: (+) 82-053Homepage ((o

Multi-Comry (MCR20

azolineNatural

and Yong R

Yeungnam Univ

2,4-dione deriication of thisI (1), wuchuyu

O K2CO3

THF

then triphogene

RNH2

Scheme 1

N

N

O

O

O

2

chuyuamide II

ing products w

erocyclic Che

ouzid, K. A. M

93, 8, 761. Y. P.; DaSilvad. Chem. Lett.T. J.; Kulp, Rn, J. M.; Lauul. Pharmacol. ee, J.-H.; Lee,

S JiangSu Un

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NH

N

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R

NH

with quinazoli

mistry II; Kat

M.; Toubar, R

a, C.; Hayes, E2005, 15, 751

R. A.; Hartzleruron, P. M. M1988, 33, 672, J.-J. J. Asian

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Yeungnam Un

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R. A.; Todd, M

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M. H. J. Med.

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15


One-pot synthesis of 5-sulfonamidopyrazoles from terminal alkynes, sulfonyl azides, and hydrozones

Yao Li, Deng Hong, Yuanxun Zhu, Ping Lu* and Yanguang Wang*


5-Aminopyrazoles are useful intermediates for the synthesis of pyrazolo[3,4-b]pyridines1, which are an important class of heterocyclic compounds due to their structural analogy to purine bases and their broad range of bioactivities. We developed an efficient, one-pot synthesis of 5-sulfonamidopyrazoles from terminal alkynes, sulfonyl azides and hydrazones. We used hydrazones, which could be easily prepared from phenylhydrazines and benzaldehydes, to trap the in situ generated ketenimines2,3 and obtained cyclization products in a cascade process. This sequential reaction includes a copper-catalyzed three-component reaction, a Lewis acid-catalyzed electrocyclic reaction and a dehydrogenation.

Figure 1. One-pot synthesis of 5-sulfonamidopyrazoles

Figure 2. Crystal Structure

Scheme 1. Proposed mechanism

Reference

1 Bruno, O.; Brullo, C.; Bondavalli, F.; Schenone, S.; Ranise, A.; Arduino, N.; Bertolotto, M. B.; Montecucco, F.; Ottonello, L.; Dallegri, F.; Tognolini, M.; Ballabeni, V.; Bertoni, S.; Barocelli, E. J. Med. Chem. 2007, 50, 3618

2 Lu, P.; Wang, Y. G. Synlett 2010, 165.

3 Rostovtsev, V. V.; Green, L. G.; Fokin, V. V.; Sharpless, K. B. Angew. Chem., Int. Ed. 2002, 41, 2596.

Yao Li was born in 1986 in Xi’an, Shaanxi Provice, PRC. She reveived her B.S. (2009) degree from Dalian University of Technology. From 2009 to present she did research under the supervision of Prof. Yanguang Wang and Prof. Ping Lu at Department of Chemistry, Zhejiang University as M.S. candidate. Her major interest was focused on multi-component reaction.

E-mail: [email protected]

N NPh

HN

Ph

Ts

Cl

16


Multicomponent Reactions for the Rapid Synthesis of Diverse Bioactive Heterocycles

Xufeng Lin*, Zhenjun Mao, Xixiang Dai, Xuejian Li, Yanguang Wang

Department of Chemistry, Zhejiang Universityp, Hangzhou 310027, P. R. China

During the past decades, many novel multicomponent reactions (MCRs) have been added to the chemist’s armamentarium and successfully applied to all fields of organic chemistry. Pyrroles and indolizines are two important classes of heterocyclic compounds as they widely occur as key structural subunits of many bioactive

natural products, organic conducting materials, and pharmaceutical substances. Based on the continuous interest on MCRs and heterocycle chemistry, we herein report the rapid and efficient multicomponent synthesis of pyrroles and indolizines.

Extention of Methodology Towards the Multicomponent Synthesis of Indolizines

ArCOCH2BrArCOCH2Br +

CHO

CO2Et

NNa2CO3

MeCNreflux 12 h

N

CO2Et

Ar

OAr

O

8 examples Yield: 55-96%

Reference

1 Xufeng Lin *, Multicomponent Reactions. Curr. Org. Chem., 2010, 14, 331.

2 Xufeng Lin*, Z. Mao, X. Dai, P. Lu, Y. Wang*; Chem.Commun. 2011, 47, 6620

3 Hong, D; Lin, X. F.*; Zhu, Y.; Lei, M.; Wang, Y. G.* Organic Lett., 2009, 11, 5678.

Xufeng Lin (林旭锋), Zhejiang Univ. (B.Sc. 2000), Zhejiang Univ. (Ph.D. 2005), Zhejiang Univ. (Postdoc. 2005-2006), Stanford University ( Visiting Scholar with Prof. Barry M. Trost, 2010-2011), Assoc. Prof. in Zhejiang Univ (2007-present). Research field: Asymmetric Catalysis and synthetic organic chemistry with emphasis on Multicomponent reactions, Tandem reactions and Heterocycles.

Fax: (+86) -571-87953816 ; E-mail: [email protected] Tel: (+86) -571-87952759

17


A Novel Dual Anti Tumor Agent: Inhibiting Tumor Growth and Preventing from Tumor Metastasis

Gang LIU*

Department of Pharmacology and Pharmaceutical Sciences, School of Medicine,

Tsinghua University, Haidian District, Beijing 100084, People’s Republic of China

Conjugates of paclitaxel and muramyl dipeptide’s analogs were synthesized as a novel agent of dual antitumor growth

and metastasis activities. In vitro and in vivo tests show that the designed compounds retain the ability to inhibit tumor

growth, while add a ability to prevent from tumor metastasis in tumor-bearded mice. The present studies indicate that

compounds suppress myeloid derived suppressor cell accumulation in the spleen and bone marrow of tumor-bearing

mice, and also represses inflammatory cytokines in tumor tissue of mice.

Reference

(1) Gupta, G. P.; Massagu_e, J. Cancer metastasis: building a framework.Cell 2006, 127, 679–695. (2) Steeg, P. S. Tumor metastasis: mechanistic insights and clinical challenges. Nat. Med. 2006, 12, 895–904. (3) Meyers, P. A. Muramyl tripeptide (mifamurtide) for the treatment of osteosarcoma. Expert Rev Anticancer Ther. 2009, 9, 1035–1049.

Gang LIU, Ph.D., 1988-1990: Teaching Assistant, Chemistry Department, Harbin Normal University. 1990-1991: Assistant Professor, Chemistry Department, Harbin Normal University. 2000-2011: Professor & Investigator of Medicinal Chemistry and Chemical Biology, Institute of Materia Medica, CAMS & PUMC. 2011-present: Director, Professor & Investigator of Medicinal Chemistry and Chemical Biology, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University. Fax: (+) : 86-10-62797740 E-mail: [email protected] or [email protected]: http://www.imm.ac.cn/groups/liugang/index.htm

18


Ring-Transformation Reaction of Sulfur-Containing Heterocycles

Yiping Zhang, Hanfeng Ding, and Cheng Ma*

Department of Chemistry, Zhejiang University, Hangzhou, 310027, P. R. China

Sulfur-containing heterocycles are of prominent importance because of their potential as bioactive compounds and synthetic building blocks.

Consequently, the construction of these molecules, especially those via C–S bond forming as well as bond cleavage reaction, represents a

significant area in organic synthesis. On the other hand, the unique reactivity of organosulfur compounds arisen from the formation, cleavage

or rearrangement of C–S bond has attracted enormous interest from synthetic chemists. As a part of our ongoing research, we present herein

a few interesting ring-transformation reactions of sulfur-containing heterocycles such as thiazole and alkylidenethiirane derivatives.

CR2

S

R1PhO2S

R

S

PhO2S

R2

R1

R3

N

S

O

R1

R2

R3

EWG2

EWG1

R4

R5

N

S

S

alkylidenethiirane

thiazole

O

R1

R2

NH

CO2Me

CO2MeR

Figure 1. Ring-transformation reaction of thiazole and alkylidenethiirane derivatives

Reference

1 (a) Chem. Commun. 2009, 4729–4731; (b) Angew. Chem. Int. Ed. 2010, 49, 9210–9214.

2 (a) Org. Lett. 2005, 7, 1343–1345; (b) J. Org. Chem. 2005, 70, 8919–8923; (c) Angew. Chem. Int. Ed. 2006, 45, 7793–7797.

Acknowledgment: The authors thank the National Natural Science Foundation of China and Fundamental Research Funds for the Central Universities for financial support.

Cheng Ma received his B. Sc. (1991) from Lanzhou University, Ph. D. (1999) from Zhejiang University. After a two-year post-doctoral study in the area of biology, he joined the Department of Chemistry of Zhejiang University in 2001, and was prompted to be a full professor since 2006. His current research interests include MCRs, ring-transformation reactions of heterocyclic compounds, organocatalytic reactions, and ketene chemistry.

Fax: (+86) 0571-87953375; E-mail: [email protected] Homepage: http://mypage.zju.edu.cn/0099120

19


Multi-Component Reactions at Interfaces: a Promising Technology for Organic Synthesis

Ilya D. Shulepov, Vladislav S. Ponamorev, Maria N. Ivantsova, Maria I. Tokareva and

Maxim A. Mironov*

Department of Technology for Organic Synthesis, Ural Federal University, Mira 19, 620002 Ekaterinburg, Russian Federation

Water is known to be an irreplaceable solvent and reagent for biochemical transformations, which are notable for highest selectivity and atom efficiency. In the past, synthetic organic chemistry did not practically use water as a solvent due to bad solubility and, in some cases, instability of organic reagents in aqueous solutions. Now, it is recognized that organic reactions in two- or multi-phase systems often give better results than in true solutions and insolubility of final products facilitates their isolation. Simplicity, selectivity, ease of purification, and atom-economy are all attractive features of reactions in aqueous suspensions, emulsions; micellar and microgels solutions. It will also provide a basis for new green technologies, including reducing the number of steps required to prepare useful products and decreasing their production costs.

Multi-component reactions (MCRs) have been highly useful in the generation of libraries of molecules used for biological screening. This is because they are able to form a carbon-carbon bond and other carbon-heteroatom bonds under very mild conditions, particularly without the demanding reaction conditions of an anhydrous or oxygen-free environment. However, rate acceleration of MCRs is a great problem, because traditional catalysis is not usually applicable to them. Some MCRs including several variants of the Ugi and Passerini reactions can be accelerated up to 300-fold (compared to organic solvents) by conducting them in water or in aqueous solutions of solutes (glucose or LiCl)1,2. Despite these impressive results the use of water as a solvent for MCRs cannot be considered a mainstream approach, because the acceleration effect has been demonstrated only for select reactions. The generalization of these results to many more MCRs is the aim of our current research 3-5.

This lecture will be focused on the following topics:

1. Acceleration of the Passerini reaction in aqueous emulsions and micellar solutions. 2. Acceleration of the Ugi reaction in aqueous emulsions and micellar solutions. 3. Finding of novel MCRs in multi-phase aqueous systems. 4. Formation of polysaccharide microgels via MCRs. 5. Some remarks about the mechanism of acceleration effect at interfaces. Reference

1 Pirrung, M. C.; Sarma, K. D. Multi-component reactions are accelerated in water. J. Am. Chem. Soc. 2004, 126, 444.

2 Mironov, M.A.; Ivantsova, M.N.; Mokrushin, V.S. Ugi reaction in aqueous solutions: a simple protocol for libraries production. Mol. Divers. 2003, 6, 193.

3 Mironov, M.A.; Ivantsova, M.N.; Tokareva, M.I.; Mokrushin, V.S. Acceleration of the Passerini reaction in the presence of nucleophilic additives. Tetrahedron Lett. 2005, 46, 3957.

4 Mironov, M.A.; Ivantsova, M.N.; Mokrushin, V.S. A novel isocyanide-based multicomponent reaction: An easy access to substituted propionamides and succinimides. Synlett 2006, 615.

5 Kolontsova A. N., Ivantsova M. N., Tokareva M. I., Mironov M. A. Reaction of isocyanides with thiophenols and gem-diactivated olefins: a one-pot synthesis of substituted 2-aminopyrroles. Mol. Divers. 2010, 14, 543.

Since 2006 research group leader and assistant professor at Ural Federal University

In 1996-2006 principal scientist and director of combinatorial chemistry in contract research company TOSLab

Chairman of MCR 2009 in Ekaterinburg, Russia

Fax: (+) 7 343 375 4135; E-mail: [email protected] Homepage: www.toslab.com

20


Sequentially Pd- and Pd-Cu-Catalyzed Processes in Multi-component and Domino Syntheses of Heterocycles

Thomas J. J. Müller

Lehrstuhl für Organische Chemie, Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, Germany

Multi-component and domino reactions are efficient and effective methods in the rapid and diversity-oriented synthesis of heterocycles. In particular, transition metal catalyzed multi-component sequences have recently gained a considerable interest.1 Based upon the Pd-catalyzed entry to ynones, diynones, and enones2 and sequentially Pd-catalyzed processes3 we have opened new avenues to one-pot syntheses of numerous classes of heterocyclic frameworks (Figure 1).4 Most interestingly, in sequentially Pd-catalyzed processes the same catalyst source is operative a second time without further catalyst addition. This one-pot methodological concept is most elegantly applied to the syntheses of halochromic luminescent pyranoindoles,3e butadiynes,3f and to very concise syntheses of marine alkaloids and kinase inhibitors, the latter by applying a general Masuda-borylation-Suzuki-arylation sequence.5

Figure 1. One-pot transformations based upon sequentially Pd and Pd/Cu-catalyzed processes

Reference

1 D. M. D’Souza, T. J. J. Müller, Chem. Soc. Rev. 2007, 36, 1095.

2 a) E. Merkul, J. Dohe, C. Gers, F. Rominger, T. J. J. Müller, Angew. Chem. Int. Ed. 2011, 50, 2966. b) T. J. J. Müller, Top. Heterocycl. Chem. 2010, 25, 25.

3 a) T. J. J. Müller, Top. Organomet. Chem. 2006, 19, 149. b) A. S. Karpov, E. Merkul, T. Oeser, T. J. J. Müller, Chem. Commun. 2005, 2581. c) W.-W. Liao, T. J. J. Müller, Synlett 2006, 3469. d) E. Merkul, C. Boersch, W. Frank, T. J. J. Müller, Org. Lett. 2009, 11, 2269. e) J. Schönhaber, W. Frank, T. J. J. Müller, Org. Lett. 2010, 12, 4122. f) E. Merkul, D. Urselmann, T. J. J. Müller, Eur. J. Org. Chem. 2011, 238.

4 B. Willy, T. J. J. Müller, Curr. Org. Chem. 2009, 13, 1777.

5 a) E. Merkul, E. Schäfer, T. J. J. Müller, Org. Biomol. Chem. 2011, 9, 3139. b) B. O. A. Tasch, E. Merkul, T. J. J. Müller, Eur, J. Org. Chem. 2011, accepted.

Thomas J. J. Müller

Born in Würzburg, Germany, in 1964. Studies of chemistry at the Ludwig-Maximilians-Universität München (LMU) (Diploma in 1989; Ph.D. in 1992). Post-doctoral stay with Prof. B. M. Trost at Stanford University (USA) (1993/1994). 1994-2001 independent research at the Technical University Darmstadt and LMU (habilitation in 2000). 2002-2006 professor of organic chemistry at the Ruprecht-Karls-Universität Heidelberg. Since 2006 chair of organic chemistry at the Heinrich-Heine-Universität Düsseldorf.

Fax: (+)49 (0)211 81 14324; E-mail: [email protected] Homepage: http://www.tjjmueller.de

21


Concise Synthesis and Structural Diversification of Natural Product Analogues

Hiroki Oguri*

(Division of Chemistry, Graduate School of Science, Hokkaido University)

Taking into account for the biosynthetic strategy elucidated by our group,1,2 we devised synthetic

processes featuring (1) modular assembly of building blocks, (2) divergent cyclizations, and (3) oxidative manipulations to produce natural product analogues with skeletal and stereochemical variations. In this conference, we will present concise synthesis and structural diversification of fused scaffolds reminiscent of indole alkaloids3 and sesquiterpenes.4

To generate three-dimensional structural variations of the core scaffolds in common with the anti-protozoal sesquiterpenes, we envisioned stereochemical diversification of the consecutive ring-junctions into three types. Exploiting a versatile maniold that allows rapid and stereo-divergent assembly of building blocks, tricyclic skeletons with systematic variation of their stereochemistries and skeletal arrays were synthesized. Further oxidative manipulations allowed installation of endoperoxides and its equivalents to produce artemisinin analogs as lead candidates for anti-trypanosomal agents.5

Figure 1. Concise synthesis and structural diversification of sesquiterpene analogs to generate anti-trypanosomal lead candidates.

Reference: (1) Shichijo, Y.; Migita, A.; Oguri, H.*; Watanabe, M.; Tokiwano, T.; Watanabe, K.; Oikawa, H.* J. Am. Chem. Soc.

2008, 130, 12230. (2) Koketsu, K.; Watanabe, K.; Suda, H.; Oguri, H.; Oikawa, H.* Nature Chem. Biol. 2010, 6, 408. (3)

Mizoguchi, H.; Oguri, H.*; Tsuge, K.; Oikawa, H. Org. Lett. 2009, 11, 3016. (4) Oguri, H.*; Yamagishi, Y.; Hiruma, T.; Oikawa,

H. Org. Lett. 2009, 11, 601. (5) Oguri, H.*; Hiruma, T.; Yamagishi, Y.; Oikawa, H.; Ishiyama, A.; Otoguro, K. et al. J. Am.

Chem. Soc. 2011, 133, 7096. Selected for the Front Cover.

Hiroki Oguri (大栗博毅), b 1970 in Tokyo, Japan. Tohoku Univ. (BA 1993, PhD 1998, Prof. Masahiro Hirama), Tohoku Univ. Assistant Professor (1998-2003, Prof. M. Hirama), Harvard Univ. Visiting Scientist (2003, Prof. Stuart. L. Schreiber), Hokkaido Univ. Associate Professor (2003-present, Prof. Hideaki. Oikawa); an investigator of CRIS in Hokkaido Univ. (2007-2010). Research field: Design, synthesis and diversification of natural product analogues and modulation of cellular functions with synthetic molecules.

Fax: (+81-11-706-3448) ; E-mail: [email protected]

Homepage (http://barato.sci.hokudai.ac.jp/~yuhan/member/index.html):

22


Multi-Step Synthesis Using a Flowed Chemical Platform

Gjergjii Shore, Mario Orestano, Eamon Comer, Stacy Bremner, Mario Orestano, Farman

Ullah, Srinivas Achanta, Virginie Liautard, and Michael G. Organ*

Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, Canada, M3J1P3

While it is pretty well accepted that advances in synthetic chemistry have provided the tools necessary to prepare any target, regardless of complexity, the focus has shifted to the practicality and sustainability of organic synthesis. Multi-component reactions, of course, are desirable as they meet these criteria. We have developed a flow chemistry approach to sustainable chemical synthesis1 wherein we have incorporated multi-component and multi-step transformations (e.g., Fig. 1) in order to maximize the efficiency. These aspects will be covered in this presentation, in addition to a backdrop for flow and microwave technology development in our laboratories.

OH

R4

R5

N

O

H

O

CH3O

R2

R4

R5

NH2

2. Heck Coupling 3. Alkylation 4. Deprotection

( )3

H2N

wave heating room temp. room temp.

Gram Quantities

Cl

O+

1. Acylationpremix with Hunig's base

room temp.

I

CH3O

R2

Br NHBoc TFA

Figure 1. Four-step flowed chemical synthesis of the natrual product Aplysamine 6.

Reference

1. For lead references, see: a) Painter, T. O.; Thornton, P. D.; Orestano, M.; Santini, C.; Organ, M. G.; Aubé, Chem. Eur. J. 2011, 16, 9595-9598. In Situ Generation and Intramolecular Schmidt Reaction of Keto Azides in a Microwave-Assisted Flow Format. B) Ullah, F.; Samarakoon, T.; Rolfe, A.; Kurtz, R. D.; Hanson, P. R.; Organ, M. G. Chem. Eur. J. 2010, 16, 10959-10962. Scaling Out by Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS): The Multi-Gram Synthesis of Bromo-benzosultams.

2. Achanta, S.; Liautard, V.; Paugh, R.; Organ, M. G. Chem. Eur. J. 2010, 16, 12797-12800. The Development of a General Strategy for the Synthesis of Tyramine-Based Natural Products Using Continuous Flow Techniques

Dr. Organ's research focuses on synthetic efficiency and more specifically on the application of tandem-reaction methodology to improve synthetic efficiency. He has pioneered the development of a new, highly efficient Pd catalyst system (PEPPSI) that has been commercialized. Dr. Organ has also developed the concept of microwave-assisted, continuous flow organic synthesis (patent pending) that is also being commercialized. Dr. Organ has developed his research into two spin-off companies: York Bioanalytical Laboratories and Total Synthesis Ltd.. He has published close to 100 manuscripts, filed 8 patent applications (several of which have been issued), given over 200 invited lectures and provided 20 short courses for the American Chemical Society on Combinatorial Chemistry in Asia, Europe and North America. He sits on the advisory boards or think-tanks of Biotage Inc., the Journal of Combinatorial Chemistry, the Journal of Flow Chemistry, and the advisory board of the University of Kansas Center for Combinatorial Methods and Library Development. Dr. Organ is an SFI Walton Fellow (2002), a Xerox Foundation Fellow (2007), a Merck-Frosst Canadian Academic Development Program Fellow (2007), the Naeja Pharmaceuticals Lecturer (2008), and is a JSPS Fellow (Japan, 2010).

Fax: 001-416-736-5936 E-mail: [email protected] Homepage: yorku.ca/organ

23


Multicomponent reaction design in the quest for

molecular complexity and diversity Romano V.A. Orru

Synthetic & Bioorganic Chemistry, Dept of Chemistry & Pharm. Sciences, VU University, Amsterdam, The Netherlands ([email protected])

The main research interest of the Synthetic & Bio-organic Chemistry group focuses on sustainable (atom and step economy) synthetic method development employing domino (or tandem) processes. The methodology is applied to the diversity-oriented synthesis of small focused libraries of fine-chemicals with a high added value, like building blocks for medicines or ligands for catalysis. A powerful strategy involves the use of multicomponent reactions (MCRs), which combine at least three different simple reagents in a well-defined manner to form a single product. Smart design of our synthetic strategies based on the concepts of Diversity Oriented Synthesis (DOS) and Biology Oriented Synthesis (BIOS) take advantage of the potential of MCRs allowing molecular complexity and diversity to be created by facile formation of several covalent bonds in one-pot transformations. At the same time our reactions proceed with high atom economy and low E factors thus minimizing the number of functional group manipulations towards a given complex molecular target and avoiding the use of protective groups.

This lecture focuses on the design, of novel MCRs for atom- and step efficient syntheses and discusses some asymmetric methodology for stereoselective MCRs employing biocatalysis. Both mechanistic aspects, stereochemistry using biocatalysis, optimization towards robust procedures and synthetic utility are discussed e.g. in the synthesis of potentially biologically active molecules (antitumor, antibiotics, hepatitis C) as well as ligands relevant to catalysis (N-heterocyclic carbene complexes, organocatalysts).

Romano V. A. Orru studied Molecular Sciences at the Agricultural University in Wageningen, the Netherlands, where he obtained his PhD in 1994 on Total Synthesis of Guainane Sesquiterpenes with prof de Groot. From 1996–2000 he worked in the group of Kurt Faber at the Technical and Karl-Franszens Universities (Graz, Austria) on biocatalysis in organic synthesis. In early 2000 he was appointed assistant professor and later associate professor at the Vrije Universiteit Amsterdam. Since 2007 he is a full professor of Synthetic and Bioorganic chemistry. His current research focuses on the development of novel, diversity oriented, synthetic methodology for the synthesis of pharmaceutically relevant compounds and natural products.

Fax: (+) 31-20-598-7488 E-mail: [email protected] Homepage (( http://www.aimms.vu.nl/en/research/research-groups/bio-organic-chemistry/more.asp )):

24


Design Strategy of Drug-like Polyheterocycles with Privileged Substructures for Discovery of Specific Small Molecule Modulators

Sangmi Oh1 and Seung Bum Park1,2,*

1Department of Chemistry & 2Department of Biophysics and Chemical Biology, Seoul National University, Seoul 151-747, Korea

The importance of molecular diversity has been clearly recognized to identify specific bioactive small molecules for the elucidation of mysterious biological processes, the crown jewel of chemical biology. The rapid and combinatorial access to molecular diversity has been pursued since early 90s by organic chemistry community. However, the enhanced efficiency in the synthesis of a large number of small molecules with a limited number of core skeletons did not significantly improve the overall numbers of new chemical entities approved by FDA. The concept of diversity-oriented synthesis (DOS) was then introduced for efficient population of molecular diversity in untapped chemical space using complexity-generating synthetic route. But, scientific communities have been curious about the molecular diversity of small molecules constructed by DOS strategies using pure complexity- generating reactions and whether they demonstrate statistically significant biological relevancy in real screening exercises. In addition, the privileged structure has been recognized as a key binding element for many different biopolymers and extensively utilized in drug discovery, though it was also claimed that library construction through modification of privileged structures is inconsistent with the true meaning of DOS for unbiased coverage of chemical space. To address these unmet needs for maximizing molecular diversity with high relevance in biological space, we pursued privileged-substructure-based DOS (pDOS) strategy to emphasize the importance of maximized skeletal diversity through the creative reconstruction of core skeletons containing privileged substructures for the construction of a drug-like polyheterocycle library. The efficiency of hit discovery from pDOS libraries was envisioned due to their enhanced relevance to biological space. This is the first systematic study to demonstrate the importance of privileged structures for the construction of molecular diversity through a series of high-throughput screening processes and subsequent biological evaluations. Our divergent pDOS strategy can provide an efficient approach for the discovery of novel small-molecule modulators with excellent specificity in chemical biology and drug discovery.

Figure 1. A schematic illustration that compares the synthetic strategies in (A) traditional combinatorial chemistry for the construction of a focused library, (B) a DOS pathway driven by pure complexity-generating reactions, and (C) the pDOS pathway

Reference

1. Design Strategy for Drug-Like Polyheterocycles with Privileged Substructures for Discovery of Specific Small-Molecule Modulators Sangmi Oh and Seung Bum Park*, Chem. Commun., 2011, in press, DOI: 10.1039/c1cc14042f.

2. Systematic Study for the Prediction of Emission Wavelength in a Full-Color-Tunable Fluorescent Core Skeleton, 1,2-Dihydropyrrolo[3,4-β]indolizin-3-one (Seoul-Fluor). Kim, E.; Koh, M.; Lim, B.J.; Park, S.B.* J. Am. Chem. Soc. 2011 133, 6642–6649.

3. Development of Novel Cy3-labeled Glucose Bioprobe and its Application in Bioimaging and Screening for Anticancer Agents. Park, J.+; Lee, H.-Y.+; Cho, M.-H.; Park, S. B.* Angew. Chem. Int. Ed. 2007, 46, 2018–2022.

25

Seung Bum Park (朴勝范) was born in 1970 in Seoul, Korea. He received B. S. (1993) and M.S. (1997) degrees from Yonsei University under the guidance of Prof. Kwan Soo Kim, and Ph.D. (2001) at Texas A&M University under the guidance of Prof. Robert F. Standaert). In 2001, he became a Howard Hughes Medical Institute Postdoctoral Fellow in the Department of Chemistry and Chemical Biology at Harvard University (Prof. Stuart L. Schreiber). In 2004, he started his independent carrier as an Assistant Professor, and promoted to an Associate Professor with tenure (2008) in Chemistry Department at Seoul National University. Currently, he has a joint appointment in the Department of Biophysics and Chemical Biology at SNU. He spent his sabbatical as a visiting Professor at the Scripps Research Institute, San Diego, USA (with Prof. Peter Schultz, 2009). He received the Young Scientist Award (Presidential Award, National Academy of Science, Korea, 2010), AstraZeneca Research Award (2010), SaeHee Jang’s Excellence Award from KCS (2010), the Korean Chemical Society/Wiley Award for Young Chemists (2009), and the Best Lecturer’s Award (2008) and the Best Research Award (2009) from Seoul National University. His research interests range from Chemical Biology, Diversity-oriented Synthesis, Combinatorial Chemistry, Bioorganic/Organic Chemistry, Medicinal Chemistry, High Throughput Screening to the Target Validation with Novel Bioprobes.

Fax: (+)82-2-884-4025 E-mail: [email protected] Homepage : http://plaza.snu.ac.kr/~sbpark/

26

N

N

NH

O

OR

S

CH3

Ar

N

N

NH2

R

S

CH3

Ar

O H

O

O

OH

+AcOH

NH

N

N

O

CH3

CH3

O

O

Br

A multi-component reaction for the synthesis of 2-(methylthio)-furopyridopyrimidinones derivatives with

popential bioligical activity

Nikolai M. Przheval’skii, Elena Rozhkova

Pyrimidine structural unit occurs in many natural and synthetic molecules exhibiting diverse biological activities. Selected examples include nitrogenous base cytosine, uracil and thymine. Recently, sulfur-containing derivatives of pyrimidine have also been reported as compounds with anti-HIV activity. 1 (A. Fig. 1).

A new derivative of pyrimidine (B) was isolated some strains of bacteria Escherichia coli which can help against diarrhea caused by toxins.2

In our continued interest in the development of highly expedient methodology3 for fine chemicals and heterocyclic compounds synthesis of biological importance, we report here the first example of the synthesis of 2-(methylthio)-furopyridopyrimidinones derivatives (4-32) from the condensation of various aldehydes (3), 2-methylthiopyrimidinone (1a, b) and tetronic acid (2) in acetic acid in the absence of any added catalyst (Scheme 1).

N

N

R

S

X

R1

R2

А В Figure 1

3a‐bb

1а R = NH2 2 4-32

1b R = ОН Scheme 1

Reference:

1. Lather V. and Madan A.K. Topological models for the prediction of anti-HIV activity of dihydro (alkylthio) (naphylmethyl) oxopyrimidines. Bioorg.&Med.Chem. 2005; 13: 1599-1609

2. Proc. Nat. Acad. Sci. USA, DOI: 10.1073/pnas.0803096105 3. Magedov I.V., Manpadi M., Van Slambrouck S., Steelant W.F.A., Rozhkova E., Przheval’skii N.M., Rogelj S., Kornienko A. Discovery and

Investigation of аntiproliferative and аpoptosis-inducing properties of new heterocyclic podophyllotoxin analogues accessible by a one-step multicomponent synthesis. J Med Chem.2007; 50: 5183-92

The 5th international Conference on multi-Component Reactions and Related Chemistry (MCR2011) Hangzhou 2011

Nikolai M. Przheval’skii was born in 1943 in Moscоw, where he graduated from the Faculty of Chemistry (Lomonosov Moscow State University).Doctor of Science (organic chemistry), the chairman of the Department of organic chemistry. Areas of his expertise concern investigations in the field of the chemistry of nitrogen heterocyclic compounds and mechanism of organic reactions.

Fax: (+7499) 9761639


27


Lewis Acid-Promoted Synthesis of Unsymmetrical and Highly Functionalized Carbazoles and Dibenzofurans from Biaryl Triazenes: the

Application for the Total Synthesis of Clausine C, Clausine R and Clauraila A

Weijun Yang, and Hongjun Ren*

Department of Chemistry, Zhejiang University

Carbazole and dibenzofuran motifs are commonly seen in bioactive nature products and they have received significant attention as synthetic

targets due to their intriguing structural features and promising biological activities. A large number of classical and no-classical methods

have been developed for the synthesis of carbazole and dibenzofuran frameworks.[1] The nucleophilic aromatic substitution of phenyl cation[2]

is a straightforward, efficient and green way to construct the carbazole and dibenzofuran cores. However, the research in this area is still rare,

for the phenyl cation is unstable which limits its application in organic synthesis. Herein, based on the generation of highly activated phenyl

cation intermediates, we describe a BF3•OEt2-promoted intramolecular amination and oxylation strategy for the direct formation of

dibenzofurans and carbazoles from biaryl triazenes under Lewis acid conditions. Furthermore, this new protocol was successfully applied to

the synthesis of nature carbazole alkaloids, such as Clausine C, Clausine R and Clauraila A.[3]

HN

MeO

CO2MeClausine C

HN

HO

CO2Me

OH

Clausine R

HN

MeO

CHO

OMe

Clauraila A

BF3.OEt2 (4eq)

HN

NH2

NN

N

CO2Et

CO2Et

N

NN

NR1R2

CO2EtN

N R2

R1

BF3.OEt2 (4eq)

EtO2C

EtO2C

DMF, 70 oC,

50% EtO2C

N

NN

N

CH3

NN

H3C

I

I

NN

N

H3C

I

I

1) i-PrMgCl.LiCl

2) Fe(acac)3

BF3.OEt2 (4eq)

EtOH, r.t., 53%

HN

CH3H3C

I I

88%

Scheme 1. the strategy for the direct formation of dibenzofurans and carbazoles from biaryl triazenes

Reference

1 a) H.-J. Knölker, K. R. Reddy, in The Alkaloids: Chemistry and Biology, Vol. 65 (Ed.: G. A. Cordell), Elsevier, Evanston, Illinois, 2008, pp. 1-430. b) H.-J. Knölker, K. R. Reddy, Chem. Rev. 2002, 102, 4303-4427.

2 a) M. Fagnoni, A. Albini, Acc. Chem. Res. 2005, 38, 713-721; b) S. Protti, M. Fagnoni, A. Albini, J. Am. Chem. Soc. 2006, 128, 10670-10671; c) V. Dichiarante, M. Fagnoni, Synlett 2008, 6, 787-800; d) A. Fraboni, M. Fagnoni, A. Albini, J. Org. Chem. 2003, 68, 4886-4893.

3 W. Yang, J. Zhou, B. Wang, H. Ren, Chem. Eur. J. 2011, <Early View>

Hongjun Ren was born in Jiangsu, China in 1975. He received his B.S. (1998) and M.S. (2001) degrees from

Zhejiang University and Ph.D. (2006) degree from Ludwig-Maximilians-Universitat Muenchen (Germany). He did the

post-doctoral research with Professor Jianghong Rao at Stanford University from 04/2007 to 03/2009 and then joined

Zhejiang University. His major research interests include new synthetic methodologies, total synthesis of natural

products and synthesis of new molecular probes for imaging.


28


A new diversity oriented synthesis of highly functionalized 3H-pyrimidin-4-ones

Renata Riva*, Luca Banfi, Andrea Basso, Paola Zito University of Genova, Department of Chemistry and Industrial Chemistry, via Dodecaneso 31, 16146 Genova (Italy), [email protected]

The pyrimidin-4-one ring is one of the privileged structures in the field of medicinal chemistry and is a characterising fragment present in many active pharmaceutical ingredients, such as risperidone, paliperidone and sildenafil. The availability of efficient synthetic routes for these scaffolds is highly desirable, especially if a combinatorial approach for preparing a large number of compounds, differing for the decorations of the heterocycle, can be realised.

Recently, we developed a four step synthesis of 2-carbalkoxy pyrimidinones from readily available susbstituted -ketoesters 1. Few acyclic common intermediates have been elaborated with a sequential increase of structure diversity, passing through the formation of key acyl enamines 2, to give a small library of 3H-pyrimidin-4-ones.1

The novelty of this approach is represented by the employment of a metal-free strategy and by the introduction, at C2, of an unexpectedly reactive functional group, instead of a simple alkyl. This opportunity means that compounds 3 can be regarded as pluripotent substrates2 because they can be further functionalized in order to increase the number of possible available structures. The particular behaviour of the 2-carbalkoxy substituent allows not only a fast entry to differently substituted compounds 4, but also the synthesis bicyclic derivatives 5.

R1 OR3

O O

R2

N

N

O

R1

R2

R4O2C

R1 OR3

NH O

R2

O

R4O2C

2 31

R5

N

N

O

R1

R2

R6

4

R5N

N

O

R1

R2

5 Scheme 1

Reference

1. Riva, R.; Banfi, L.; Basso, A.; Zito, P. Org. Biomol. Chem. 2011, 9, 2107–2122.

2. Burke, M. D.; Schreiber, S. L. Angew. Chem., Int. Ed. 2004, 43, 46–58.

Renata Riva obtained a Master in Chemistry at the University of Milano (Italy) in 1982 after carrying out an experimental Thesis under

the supervision of Prof. Bruno Danieli on the reactivity of steroids related to ecdisones. In 1987 she got a Ph. D. in Chemical Sciences

working at the University of Milano, under the supervision of Prof. Danieli, in the field of indole alkaloids. Part of the Ph. D. was carried

out at the University of Genova (Italy), in the group of Prof. Giuseppe Guanti, working the field of biocatalysis.

From november 1986 till the end of july 1987, Renata Riva worked in the U.S.A. as a postdoctoral associate in the group of Prof.

William R. Roush (at the Massachusetts Institute of Technology, Cambridge and at Indiana University, Bloomington) where she has

pursued the enantioselective synthesis of the bottom half of Chlorotricolide.

From 1987 to 1992 she worked as a Chemistry teacher in several High Schools in Genova, while continuing her collaboration with the

group of Prof. Giuseppe Guanti. In 1992 she was hired as assistant professor by the Faculty of Sciences at the University of Genova in

the group of Prof. Guanti and was promoted to associate professor in 2000.

All the research activity of Renata Riva was carried within organic synthesis, especially in these fields: a) stereoselective synthesis or

semisynthetic approaches to biologically active compounds (in particular indole alkaloids, beta-lactams, enediyne and anthracycline

antitumor compounds); b) stereoselective syntheses employing both traditional methods or biocatalytic methods (enzymes,

microorganisms); c) "diversity oriented synthesis" of possible drug candidates employing multi component and domino reactions, which

is presently the most important aspect of her research. During her career she has been involved in several research contracts with

pharmaceutical companies, in particular working on projects for the industrial production of active pharmaceutical ingredients.

The scientific activity is documented by 89 research papers on international journals, 5 patents, 15 reviews, book chapters and

proceedings.

Fax: (+39) 0103536118 E-mail: [email protected] Homepage: http://www.chimica.unige.it/Renata-Riva

29


A chemoenzymatic route to new chiral isocyanides and their use in highly diastereoselective Ugi reactions

Renata Riva*, Luca Banfi, Andrea Basso, Valentina Cerulli, Valeria Rocca

University of Genova, Department of Chemistry and Industrial Chemistry, via Dodecaneso 31, 16146 Genova (Italy), [email protected]

Peptidomimetics represent a very powerful answer to the quest for new biologically active compounds.1 This family of molecules can be used to face many different kind of diseases, such as cancer, AIDS, hepatitis, inflammatory processes and so on. For many targets conformationally restricted structures are highly desirable.

One of the most powerful strategies for assembling new peptidomimetics is represented by the isocyanide-based multicomponent reactions (IMCRs), namely the Ugi and Passerini reactions and their variants.

Restricted peptidomimetics are not necessarily fully cyclic or macrocyclic structures: in some cases it's enough to join the needed moieties, that are fundamental for the interaction with the biological target, to an appropriate central scaffold, usually having an heterocyclic structure. Moreover, for an appropriate evaluation of the biological properties of new peptidomimetics it is desirable to test single stereoisomers.

It is therefore important to be able to: 1) assemble many new structures through a diversity oriented approach, basing the synthetic efforts on a common background (the IMCRs for example); 2) control the stereochemical outcome of the IMCR; c) synthesize new tailor-made appropriate chiral building blocks to be used in the IMCR through efficient stereospecific procedures.

In this communication we present the chemoenzymatic synthesis of both enantiomers of isocyanides 3 and 4, each of them available through an efficient and enantiodivergent synthetic elaboration of the same chiral building block (1 to give 3 and 2 to give 4 respectively). Then, these isocyanides have been used for a convergent synthesis of a family of peptidomimetics exploiting an intramolecular variant of the Ugi reaction involving the chiral cyclic imine 5. This imine has been prepared in both enantiomeric forms through a chemoenzymatic sequence and, contrary to many other cyclic imines,2 display a complete induction during the formation of the new stereogenic centre arising from the MCR. The whole sequence has been demonstrated to preserve the enantiomeric excess of the enzymatically desymmetrized diols employed as precursors of the isocyanides 3 and 4 and of the cyclic imine 5.

Finally, the polarity and conformation of the adducts can be tuned by modifying the additional functional groups (also changing the oxidation state) either before or after the Ugi reaction.

NCN

X

*

Ar

OP

OAc

OH1

Ph

OAc

OH2

OR1

N

HN

O

R2

X

*

Ar

3, 4R1CO2H

6, 7

3, 6: X-Ar = CH2O-(3-Br)-C6H44, 7: X-Ar = CH2Ph6, 7: R2 = CH2OP, CO2Me

* ** *

*

complete control

5

Scheme 1.

Reference

1. Grauer, A. Eur. J. Org. Chem. 2009, 5099-5011.

2. a) Banfi, L.; Basso, A.; Guanti, G.; Riva, R. Tetrahedron Lett. 2004, 45, 6637-6640; b) Banfi, L.; Basso, A.; Guanti, G.; Merlo, S.; Repetto, C.; Riva, R. Tetrahedron 2008, 64, 1114-1134.

30

Renata Riva obtained a Master in Chemistry at the University of Milano (Italy) in 1982 after carrying out an experimental Thesis under

the supervision of Prof. Bruno Danieli on the reactivity of steroids related to ecdisones. In 1987 she got a Ph. D. in Chemical Sciences

working at the University of Milano, under the supervision of Prof. Danieli, in the field of indole alkaloids. Part of the Ph. D. was carried

out at the University of Genova (Italy), in the group of Prof. Giuseppe Guanti, working the field of biocatalysis.

From november 1986 till the end of july 1987, Renata Riva worked in the U.S.A. as a postdoctoral associate in the group of Prof.

William R. Roush (at the Massachusetts Institute of Technology, Cambridge and at Indiana University, Bloomington) where she has

pursued the enantioselective synthesis of the bottom half of Chlorotricolide.

From 1987 to 1992 she worked as a Chemistry teacher in several High Schools in Genova, while continuing her collaboration with the

group of Prof. Giuseppe Guanti. In 1992 she was hired as assistant professor by the Faculty of Sciences at the University of Genova in

the group of Prof. Guanti and was promoted to associate professor in 2000.

All the research activity of Renata Riva was carried within organic synthesis, especially in these fields: a) stereoselective synthesis or

semisynthetic approaches to biologically active compounds (in particular indole alkaloids, beta-lactams, enediyne and anthracycline

antitumor compounds); b) stereoselective syntheses employing both traditional methods or biocatalytic methods (enzymes,

microorganisms); c) "diversity oriented synthesis" of possible drug candidates employing multi component and domino reactions, which

is presently the most important aspect of her research. During her career she has been involved in several research contracts with

pharmaceutical companies, in particular working on projects for the industrial production of active pharmaceutical ingredients.

The scientific activity is documented by 89 research papers on international journals, 5 patents, 15 reviews, book chapters and

proceedings.

Fax: (+39) 0103536118 E-mail: [email protected] Homepage: http://www.chimica.unige.it/Renata-Riva

31


Multicomponent Approaches to Organic Synthesis and Chemical Biology

JARED THOMAS SHAW

Department of Chemistry, University of California, One Shields Ave, Davis CA 95616

The development of new multicomponent reactions (MCRs) based on cyclic anhydrides will be described. New 3CRs and 4CRs offer rapid access to complex lactams with up to three new stereogenic centers. Reaction products are useful for high-throughput screening and for further functionalization toward complex natural products.

Figure 1.

Prof. Jared Shaw, Assistant Professor VI, Department of Chemistry, University of California, Davis

Jared Shaw received his B.S. from UC Berkeley (1993) and his Ph.D. from UC Irvine (1999) with Professor Keith Woerpel. He was an NIH postdoctoral fellow with David Evans at Harvard University (1999-2002) and an institute fellow at the Broad Institute of Harvard and MIT (2002-2007) before joining UC Davis. Prof. Shaw’s research interests include multicomponent reactions, natural product synthesis, and chemical biology.

Fax: (+01) 5307529979 ; E-mail:[email protected]

32


Synthesis of Iminocoumarins, Quinazolinones and Isoquinolinones via Ketenimine Intermidiate

Yang Shena, Chao Hana, Sunliang Cuia, Xufeng Lina, Ping Lua, Yanguang Wanga,b,*

a Department of chemistry, Zhejiang University, Hangzhou 310027, P.R. China b State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China

An efficient synthesis of N-sulfonyl-substituted 2-imino-3,4-dihydrocoumarins and 2-iminocoumarins via a copper- Iminocoumarins are one type of protein tyrosine kinase (PTK) inhibitors that are most valuable for the treatment of diseases involving excess cell proliferation as well as the antitumor process. They are also useful fluorescent dyes in fields as various as cell biology, medical analysis and sensors.k Classic methods for synthesis of iminocoumarins, such as Knoevenagel condensation and modification from coumarins, suffer from several shortcomings including limited substituents and troublesome chemical process management.

Here we report an efficient synthesis of N-sulfonyl-substituted 2-imino-3,4-dihydrocoumarins and 2-iminocoumarins via a copper-catalyzed multicomponent reaction of sulfonyl azides with terminal alkynes and b-(ortho-hydroxyphenyl)-a,b-unsaturated ketones or ortho-hydroxyphenylpropiolates has been developed. The cascade process involves trapping the keteimine by a

nucleophilic addition and an intramolecular Michael addition.

4(3H)-Quinazolinones and isoquinolinones are important class of fused heterocyclic compounds, have attracted much synthetic attention because of their wide range of pharmacological and therapeutic activities such as anticancer, antiinflammatory, anticonvulsant, antiulcer, and hypolipidemic. Some quinazolinones have been reported as potent chemotherapeutic agents in the treatment of tuberculosis. The bioactive natural products, febrifugine and isofebrifugine, contain a quinazolinone moiety and possess antimalarial activity.

Based on previous work, we developed an one-pot four-component approach to synthesis 4(3H)-quinazolinones and isoquinolinones efficiently. This process involved a three component reaction of sulfonylazides with terminal alkynes and aniline. Cascadly the CO was employed to generate target heterocyclic compounds. This procedure is general and efficient

Reference

1 S. L. Cui, X. F. Lin, Y. G. Wang, Org. Lett. 2006, 8, 4517-4520. 2 S. L. Cui, J. Wang, Y. G. Wang, Org. Lett. 2007, 9, 5023-5025. 3 E. J. Yoo, S. Chang, Org. Lett. 2008, 10, 1163 – 1166.

Yang Shen was born in Zhejiang, China in 1984. He reveived his B.S. (2007) degree from Zhejiang University. From 2007 to present he did research with Professor Yanguang Wang at Department of Chemistry, Zhejiang University as Ph.D. candidate. His major interest was focused on multi-component reaction via ketenimine intermidiate.

Fax: (+86)-571-87953816 ; E-mail: [email protected]: http://weibo.com/ericshen203

C C N

R1 SO2N3

+R2

Et3 NCuI

(A)

(B)

C or C+D

+

C

O

R2

NSO2R1

R4

EWG c+ co

c+ co

R2

N

C

HN O

R3

N

O

NHSO2R1

R2

33


Regioselective Construction of Enantiopure 1,3-disubstituted Tetrahydroindazolone Library for the Study of Stereochemical

Diversity

Heebum Song† ‡,Seung Bum Park*† ‡

†Department of Chemistry and ‡Department of Biophysics and Chemical Biology, Seoul National University, Seoul 151-747, Korea

Tetrahydroindazolone derivatives has received significant attention as a pharmacophore. For example, SNX-

2112, containing tetrahydroindazolone moiety as core skeleton, is a famous potent heat shock protein (HSP) 90 inhibitor in phase III chlinical trial. Despite their proven importance in biomedical research, robust and efficient synthesis of tetrahydroindazolone derivatives is still challenging. Most vulnerable point in tetrahydroindazolone synthesis is difficulty of regioselectivity control. General procedure for tetrahydroindazolone synthesis in reported literatures is condensation of 2-acylcyclohexane-1,3-diones with hydrainzes. This method is valid for arylhydrazines generally,but for very limited scope of alkylhydrazines.To address this problem, we have carried out research on regioselective synthesis and library construction of tetrahydroindazolone moiety. We reported regioselective synthetic pathway of complementary regioisomers of 1,2- and 1,3-disubstituted tetrahydroindazolones through the sequential protection and deprotection of hydrazines.And we also reported the practical solid-phase synthetic pathway for 1,3-disubstituted tetrahydroindaozlones.

As an extension of our research, we develop a new regioselective synthetic pathway of 1,3-substituted tetrahydroindazolone generally applicable for broad kinds of substrates including alkylhydrazines as well as arylhydrazines. The key concept of our synthetic strategy is introducing sterically hindered N-Bocpyrrolidine ring on 2-acylcyclohexane-1,3-done. The advantages as introducing N-Bocpyrrolidine ring on 2-acylcyclohexane-1,3-dione are; (i) N-Bocpyrrolidine is sterically bulky group sufficient to give regioselectivity in the synthesis of 1,3-disubstituted tetrahydroindazolone irrespective of kinds of hydrazines (ii) improvement of efficiency for discovering lead compound for small-molecule modulator because pyrrolidine moiety is frequently observed in many bioactive small molecules such as anti-hyperglycemic agent and angiotensin-converting-enzyme (ACE) inhibitor(Figure 1) (iii) making R/S enantiomeric pair tetrahydroindazolone sets easily because each enantiomer can be synthesized simply by changing L- or D-proline (iv) pyrrolidine moiety can be utilized as a diversiting point to maximize molecular diversity via N-modification.

H2N

HN

R1

O

O

OH

NBoc

+

1

3

NN

O

R1

NBoc

4a - 4h 5a - 5h

NN

O

R1

NH

NN

O

R1

N R2

O

NN

O

R1

NHN

XR2

NN

O

R1

NS

R2

O O

A) AmideFormation

B) Urea orthiourea formation

C) Sulfonamideformation

*

*

*

*

*

*

34


Four-Component Reaction of N-Sulfonyl Imines, (Cyanomethylene)triphenylphosphorane, Nitromethane, and Formaldehyde for the Synthesis of 3-Substituted 2-Methylene-4-nitrobutanenitriles

Yin-Huan Jin, Fan Fang, Xiang Zhang, Qing-Zhou Liu, Hao-Bo Wang, and Shi-Kai Tian*

Joint Laboratory of Green Synthetic Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China

Multicomponent reactions are very powerful for the construction of complex organic molecules by transforming in a one-pot manner three or more starting materials into a single product that incorporates portions of all the reactants, and exhibit much higher efficiency relative to the sequential synthesis of the same targets by conventional bimolecular reactions.1 In the course of exploring the complete cleavage of carbon-nitrogen double bonds for stereoselective alkene synthesis,2 we found that the four-component reaction of N-sulfonyl imines, (cyanomethylene)triphenylphosphorane, nitromethane, and formaldehyde proceeded smoothly at room temperature to afford structurally diverse 3-

substituted 2-methylene-4-nitrobutanenitriles in good to excellent yields.3 The starting materials are all readily accessible, and no catalyst or additive is needed at all in this four-component reaction. Moreover, the Rauhut-Currier-type products have not been accessed so far by the corresponding reaction of nitroalkenes with acryl nitrile or by other methods. This study not only adds a useful entry to multicomponent reactions that are increasingly demanding owing to their intrinsic step-economy in the construction of complex organic molecules, but also significantly extends the synthetic utility of carbon-nitrogen bond cleavage.

MeNO2CN

PPh3

HCN

CH2

R

NO2

+rt

HCHO+R

N

H

Ts

+

References

1 For reviews, see: (a) Ganem, B. Acc. Chem. Res. 2009, 42, 463. (b) Dondoni, A.; Massi, A. Acc. Chem. Res. 2006, 39, 451. (c) Dömling, A. Chem. Rev. 2006, 106, 17. (d) Multicomponent reactions Zhu, J., Bienaymé, H., Eds.; Wiley-VCH: Weinheim, Germany, 2005. (e) Ramón, D. J.; Yus, M. Angew. Chem., Int. Ed. 2005, 44, 1602. (f) Zhu, J. Eur. J. Org. Chem. 2003, 1133. (g) Nair, V.; Rajesh, C.; Vinod, A. U.; Bindu, S.; Sreekanth, A. R.; Mathen, J. S.; Balagopal, L. Acc. Chem. Res. 2003, 36, 899. (h) Orru, R. V. A.; Greef, M. Synthesis 2003, 1471. (i) Döemling, A.; Ugi, I. Angew. Chem., Int. Ed. 2000, 39, 3168.

2 (a) Dong, D.-J.; Li, H.-H.; Tian, S.-K. J. Am. Chem. Soc. 2010, 132, 5018. (b) Dong, D.-J.; Li, Y.; Wang, J.-Q.; Tian, S.-K. Chem. Commun. 2011, 47, 2158. (c) Fang, F.; Li, Y.; Tian, S.-K. Eur. J. Org. Chem. 2011, 1084.

3 Jin, Y.-H.; Fang, F.; Zhang, X.; Liu, Q.-Z.; Wang, H.-B.; Tian, S.-K. J. Org. Chem. 2011, 76, 4163.

Shi-Kai Tian received his B.S. degree from Lanzhou University in 1993. He obtained both his M.S. and Ph.D. degrees from Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, in 1996 and 1998, respectively. He joined the Deng group at Brandeis University as a postdoctoral fellow in 1999, and three years later he was employed as a medicinal investigator at Vertex Pharmaceuticals Inc. Since 2005 he has been a professor of chemistry at the University of Sciences and Technology of China. His current research focuses on developing new synthetic methods based on the transformations of nitrogen-containing compounds, particularly those with carbon–nitrogen bond cleavage.


35


Effects of nanosized metal oxides on regio- and stereo-features for the synthesis of dihydroazolopyrimidines

Julia Titova*a, Sergey Zhidovinova, Olga Fedorovaa, Gennady Rusinova, Olga Alisiyonokb, Anna Lavitskayab, Anna Murashkevichb, Ivan Zharskyb,Valery Charushina

a I. Postovsky Institute of Organic Synthesis of RAS, S. Kovalevskoy/Akademicheskay st., 22/20, 620041, Ekaterinburg, Russia b Belarusian State Technological University, Sverdlova st., 13a, 220006, Minsk, Belarus

Substituted dihydroazolopyrimidines 1 and 2 have been prepared by the multicomponent Biginelli reaction with urea

isosteres, such as 3-amino-1,2,4-triazole and 5-aminotetrazole [1]. It has been established that the formation of

dihydroazolopyrimidines requires a more hard reaction conditions (7-8 hours of reflux in DMF) and proved to be a less

selective process than the classical Biginelli reaction leading to dihydropyrimidines [2].

For the first time the effects of nanosized metal oxides (CuO, Al2O3, ZnO, MgO, TiO2-SiO2), including the presence

of chiral modifiers, on regio- and stereoselective features of the multicomponent synthesis of dihydroazolopyrimidines 1

and 2 have been studied (scheme 1). Using of nanosized system TiO2-SiO2 allowed one to optimize the synthesis of 2, to

reduce the reaction temperature from 80 °C to 22 °C, and to enhance content of the target compound up to 90-92%

according to HPLC. It has been shown that the presence of nanosized TiO2-SiO2, ZnO and chiral modifiers (quinine

sulfate, L-proline, D-proline, 5-oxy-L-proline, D-aspartic acid) enables one to improve stereoselectivity of the synthesis

of dihydroazolopyrimidines 1 and 2. Also it is worth to note that use of chiral modifiers without nanosized metal oxides

has no effect on stereoselectivity of the reaction.

Dependence of enantiomeric excess of 1 on the ratio of SiO2 and TiO2 has shown that the best results can be achieved

with the catalyst bearing 18% of TiO2. By using of this nanosized metal oxide, L-proline and DMF as solvent the ee has

been enhanced up to 30-45%. In case of derivatives 2 the presence of ZnO and L-proline provided the value of 20% for

the dihydrotetrazolopyrimidines 2.

NH

Me

EtO2C N

NXN

O O

MeEtOO H

NHXN

NNH2

+ 1, X=CH2, X=N

*+

Scheme 1. Synthesis of dihydroazolopyrimidines Reference

1. Fedorova, O.V., Zhidovinova, M.S., Rusinov, G.L., Ovchinnikova, I.G., Rus. Chem. Bull., International Edition, 2003, (8)52, p. 1768-1769. 2. Zhidovinova, M.S., Ovchinnikova, I.G., Matochkina, E.G., Kodess, M.I., Van der Eycken, E., Van Meervelt, L., Fedorova, O.V., Rusinov, G.L.,

Vestnik UGTU-UPI, Ser. Khim., 2005, (5)57, p. 164-167.

Julia Titova was born in 1986 in Ekaterinburg (Russia) and graduated from the Ural State Technical University in 2003. After that she began her post-graduate studies in I. Postovsky Institute of Organic Synthesis of Ural Branch of the Russian Academy of Sciences. Her research interests involve studying of catalytic effects of nanosized metal oxides on the regio- and stereoselectivity of multi-component reactions.

Fax: (+343) 369 30 58 ; E-mail: [email protected]

36


The efficient construction of several fused heterocyclic skeletons based on multi-component domino reactions

Bo Jiang and Shu-Jiang Tu*

School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, 221116, Jiangsu, P. R. China

Multi-component domino reactions (MDRs) have been highlighted as one of research frontier, widely used for the construction of heterocycles and in total synthesis and combinatorial chemistry. These reactions can avoid time-consuming and energy-costing processes that involve multi-step syntheses, protection-deprotection, tedious work-up and purifications. Therefore, domino reactions are environmentally friendly and often proceed with excellent stereo and chemoselectivities.1 Our interest focused on domino reactions, and a series of novel heterocyclic compounds involving in more complex structures and in part original nucleus were synthesized based on MDRs (Scheme 1).2-4 The starting materials have been maximized to convert into the desired compounds, avoiding time-consuming and energy-costing processes that involve multi-step syntheses. So, these reactions have the advantage of atom economy, high synthetic efficiency and environmental friendliness, which offer a valuable addendum to methodology for the synthesis of heterocycles

MDRs

HN

NH

O O

CN

NH2

ArH

H

X n( )

HN

OR

NH2CN

X( )n

J. Am. Chem. Soc.2009, 131, 11660-11661

2010, 12, 1357-1361

Org. Biomol. Chem.2011, 9, 3834-3838

J. Org. Chem.2010, 75, 2962-2965

Green Chem.

OO

NHN

X

O

OAr

Ar

N

N

NH

NH

O

O

R1

R2

R1

R2

Green Chem. 2011, 13, 2107-2115

N XN

RN

N

( )n

N

CN

NH2

CN

NH2

( )n

R

R

Org. Biomol. Chem.2011, 9, 4025-4028

NH

NR3

R2

O

R1

R1

O

O

Tetrahedron2011, 67, 4485-4493

Scheme 1. Reference

1 (a) Tietze, L. F.; Brasche, G.; Gericke, K. Domino Reactions in Organic Synthesis, Wiley-VCH, Weinheim, 2006; (b) Tietze, L. F. Chem. Rev. 1996, 96, 115-136.

2 Jiang, B.; Tu, S.-J.; Kaur, P.; Wever, W.; Li, G. J. Am. Chem. Soc. 2009, 131, 11660–11661; (b) Jiang, B.; Li, C.; Shi, F.; Tu, S.-J.; Kaur, P.; Wever, W.; Li, G. J. Org. Chem. 2010, 75, 2962-2965. (c) Ma, N.; Jiang, B.; Zhang, G.; Tu, S.-J.; Wever, W.; Li, G. Green Chem., 2010, 12, 1357-1361. (d) Cheng, C.; Jiang, B.; Tu S.-J.; Li, G. Green Chem., 2011, 13, 2107–2115.

3 (a) Jiang, B.; Zhang, G.; Ma, N.; Shi, F.; Tu, S.-J.; Kaur, P.; Li, G. Org. Biomol. Chem., 2011, 9, 3834-3838. (b) Jiang, B.; Wang, X.; Shi, F.; Tu S.-J.; Li, G. Org. Biomol. Chem. 2011, 9, 4025-4028. (c) Wang, S.-L.; Cheng, C.; Wu, F.-Y.; Jiang, B.; Shi, F.; Tu, S.-J.; Rajale, T.; Li, G. Tetrahedron, 2011, 67, 4485-4493.

4 Jiang, B.; Hao, W.-J.; Zhang, J.-P.; Tu, S.-J.; Shi, F. Org. Biomol. Chem. 2009, 7, 1171-1175; (b) Jiang, B.; Hao, W.-J.; Zhang, J.-P.; Tu, S.-J.; Shi, F. Org. Biomol. Chem., 2009, 7, 2195–2201; (c) Jiang, B.; Cao, L.-J.; Tu, S.-J.; Zheng, W.-R.; Yu, H.-Z. J. Comb. Chem. 2009, 11, 612-616.

Shu-Jiang Tu was born in 1957 in Jiangsu (China), and received his B.Sc. in 1983. He was appointed as assistant professor at the Xuzhou Normal University in 1999, and was promoted to full Professor in 2003. His current interests are the development of new synthetic methods, green chemistry, and microwave multicomponent syntheses.

Fax: (+86)51683500065 ; E-mail: [email protected]

37


MICROWAVES AND MULTI-COMPONENT REACTIONS IN THE SYNTHESIS OF MEDIUM-SIZED RINGS Van der Eycken Erik* Department of Chemistry, Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Heverlee (Leuven), Belgium Medium-sized rings are abundantly present in many biologically active (natural) products as e.g. the alkaloids aphanorphine, lennoxamine and cephalotaxine and the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist Dizocilpine, also known as MK-801. However, the synthesis of medium-sized rings is known to be rather cumbersome and no good generally applicable procedures have been described so far. Some time ago we have elaborated an efficient synthesis of the 3-benzazepine framework via an intramolecular Heck reductive cyclization (1). We have demonstrated that the application of microwave irradiation is beneficial for this process. As a result of these investigations we extended our research towards the synthesis of indoloazocines (2), dibenzoazocines (3), dibenzoazepines (3), 3-benzazepines (4) and dibenzo[c,e]azepinones. To assure the generation of diversity we utilized multicomponent reactions as the aldehyde/amine/alkyne (A3) coupling (5,6) and the Ugi 4CR (Scheme) which will be run in an intramolecular fashion. The beneficial effect of the application of microwave irradiation in each of these processes will be commented.

Scheme 1: Application of the U4CR for the diversity-oriented generation of dibenzo[c,e]azepinones.

Reference

1) Efficient Synthesis of the 3-Benzazepine Framework via Intramolecular Heck Reductive Cyclization, P. A. Donets, E. Van der Eycken, Org. Lett., 9, 3017-3020, 2007. 2) Efficient Synthesis of the Indoloazocine Framework via Intramolecular Alkyne Carbocyclization, P. A. Donets, K. Van Hecke, L. Van Meervelt, E. V. Van der Eycken, Org. Lett., 11, 3618-3621, 2009. 3) Diversity-Oriented Synthesis of Dibenzoazocines and Dibenzoazepines via a Microwave-Assisted Intramolecular A3-Coupling Reaction, J. B. Bariwal, D. S. Ermolat’ev, T. N. Glasnov, K. Van Hecke, V. P. Mehta, L. Van Meervelt, O. C. Kappe, E. V. Van der Eycken, Org. Lett., 12, 2774-2777, 2010. 4) Diversity-Oriented Microwave-Assisted Synthesis of the 3-Benzazepine Framework, V. A. Peshkov, O. P. Pereshivko, P. A. Donets, V. P. Mehta, E. V. Van der Eycken, Eur. J. Org. Chem., accepted, 2010. 5) Efficient Microwave-Assisted Synthesis of Secondary Alkyl Propargylamines via A3-coupling with Primary Aliphatic Amines, J. B. Bariwal, D. S. Ermolat’ev, E. V. Van der Eycken, Chem. Eur. J., 16, 3281-3284, 2010. 6) Unprecedented Cu(I)-Catalyzed Microwave-Assisted Three-Component Coupling of a Ketone, an Alkyne and a Primary Amine, O. P. Pereshivko, V. A. Peshkov, E. V. Van der Eycken, Org. Lett., 12, 2638-2641, 2010.

COOH

CHO

R1

R2 R3 NH2

R4 NC

N

O

NH

R4

R3

O

R1

R2

COOMe

CHO

R1

R2

B(OH)2

Br

Suzuki-MiyauraUgi 4-CR

38

Erik Van der Eycken is Professor Organic Chemistry and head of the Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC) at the University of Leuven (K.U.Leuven), Belgium. He received his Master diploma (1982) and his PhD degree (1987) in organic chemistry from the University of Ghent, Belgium, with Prof. Maurits Vandewalle on the total synthesis and structural elucidation of Specionin, an iridoid insect antifeedant. From 1988 to 1992 he worked as a scientific researcher at the R&D-laboratories of AGFA-Gevaert, Mortsel, Belgium. He moved back to the University of Ghent as a scientific collaborator on photo-induced reactions with Prof. Denis De Keukeleire and Prof. Piet Herdewijn on HIV-active drugs (1992-1995). From 1995-1997 he was connected to the Flemish Inter-University Institute for Biotechnology (VIB), Ghent, with Prof. Marc Van Montagu where he was involved in the synthesis of intermediates for the elucidation of biological reaction pathways. In 1997 he became Doctor-Assistent at the K.U.Leuven, Belgium in the group of Prof. Georges Hoornaert, where he was involved in heterocyclic chemistry. He was appointed part-time professor in 2004 at the same university and started his independent academic career. After short periods of postdoctoral work at the University of Graz (2002) with Prof. C. O. Kappe on microwave-assisted hetero-Diels-Alder reactions, at The Scripps Research Institute (La Jolla, USA) (2003) in the group of K. B. Sharpless, on microwave-asssisted click chemistry, and at Uppsala University (2004) with Prof. M. Larhed and Prof. A. Hallberg on microwave-assisted carbonylations, he was appointed full-time professor in 2007 at the K.U.Leuven. The main focus of his research is the investigation of the application of microwave irradiation in different domains of organic synthesis, i.e. synthesis of bioactive natural product analogues and heterocyclic molecules applying transition metal catalyzed reactions and solid phase organic synthesis. His lab is also active in the field of microwave-assisted synthesis of (cyclic) peptides and peptidomimetics.

Fax: (+) 32/16/32.79.90 E-mail: [email protected] Homepage: http://chem.kuleuven.be/research/organ/lomac/index.html

39


A MODULAR APPROACH TO CHIRAL IMIDATES: A NEW CLASS OF N-BASED CHIRAL LIGANDS AS TOOLS FOR ASYMMETRIC CATALYSIS.

Johan Van der Eycken*, Timothy Noël, Katrien Bert, Koen Vandyck

Laboratory for Organic and Bioorganic Synthesis, Department of Organic Chemistry

Ghent University, Krijgslaan 281 (S.4), B-9000 Ghent, Belgium

[email protected]

Nitrogen-containing ligands are known as cheap, readily accessible and stable alternatives for phosphane ligands,1 which are often very sensitive to air and require a multistep synthesis.2 We wish to present a combinatorial approach to a novel type of nitrogen-based mono- and bidentate ligands.3,4 These ligands are characterized by their modular structure, allowing an easy one-step synthesis by simply combining two readily variable precursors which are either commercially available, or can be reached in only a few steps: a cyclic imidate 1 and a (chiral) amine, respectively diamine. These ligands show promising results in e.g. the Cu(I)-catalyzed asymmetric aziridination of methyl cinnamate, in asymmetric diethylzinc additions to benzaldehydes, in the Pd(0)-catalyzed asymmetric allylic alkylation, and in asymmetric hydrogenations of alkenes. These ligands might also become valuable tools for asymmetric multicomponent reactions.

References:

1. (a) Caputo, C.A.; Jones, N.D. Dalton Trans. 2007, 4627-4640. (b) Fache, F.; Schulz, E.; Tommasino, M.L.; Lemaire, M. Chem.

Rev. 2000, 100, 2159-2231.

2. (a) Federsel, H.-J. Nat. Rev. Drug Discov. 2005, 4, 685-697. (b) Hawkins, J.M.; Watson, T.J.N. Angew. Chem. Int. Ed. 2004, 43,

3224-3228.

3. (a) Noël, T.; Vandyck, K.; Robeyns, K.; Van Meervelt, L.; Van der Eycken, J. Tetrahedron 2009, 65, 8879-8884; (b) Noël, T.; Robeyns, K.; Van Meervelt, L.; Van der Eycken, E.; Van der Eycken, J. Tetrahedron: Asymmetry 2009, 20, 1962-1968; (c) Noël, T.; Bert, K.; Van der Eycken, E.; Van der Eycken, J. Eur. J. Org. Chem. 2010, 21, 4056-4061

4. For some of our previous work in the ligand field, see: (a) Noël, T.; Vandyck, K.; Van der Eycken, J. Tetrahedron, 2007, 63,

12961-12967. (b) Vandyck, K.; Matthys, B.; Willen, M.; Robeyns, K.; Van Meervelt, L.; Van der Eycken, J. Org. Lett. 2006, 8,

363-366.

O

NH

. HCl

N NO O

N

N

O

O

OO

N N

NN

N

OH

NN

O O

O O

O O

O

285% yield

371% yield

456% yield

592% yield

693% yield

791% yield

Conditions:

amine, imidate.HCl 1 (2.6 equiv),Et3N (13 equiv), CH2Cl2.

Fe

PPh2 N O

R

Cl

899% yield

1

40


Transformations of tetrahydrobenzothieno(furo)[2,3-c]pyridines under the action of activated alkynes.

Alexey V. Varlamov*, Tatyana N. Borisova

Russian People’s Friendship University, 6, Miklukho-Maklaia St., Moscow 117198, Russia;

Interaction of condensed tetrahydropyridines which have aryl(hetaryl)methylamine fragment with activated alkynes in protic solvents leads to the formation of alkoxy(hydroxy)methyl(alkyl)-substituted arenes (hetarens). Carrying out this three-component interaction in the presence of Lewis acid leads to the formation of condensed azocines II, spiro[benzothienodihydropyridines] III, spiro[benzofurodihydropyridines] IV or lactams V.

This work was financially supported by the Russian Foundation for Basic Researches (grant # 11-03-90407-Ukr_f_а)

Born in 1939 in Moscow, Russia 1963 – engineer-technologist from the Moscow Institute of Fine Chemical Technology 1972 - Ph.D in organic chemistry - “Studies on the synthesis and stereochemistry of silicon-nitrogen heterocycles” 1974 – 1985 – associated professor at the Organic chemistry department of the Russian Peoples’ Friendship University. 1985 – D.Science Organic chemistry 1987 – full professor at the Organic chemistry department of the RPFU 1989 – head of the Organic chemistry department of the RPFU Fields of interest – heterocyclic chemistry, bioactivity investigations, new synthetic methods, multicomponent reactions, Medicinal chemistry, NMR.

Fax: (+) 7 4959550779 ; E-mail: [email protected]

41


Azide Ugi-five-center-four-component reaction (U-5C-4CR) in the synthesis of tetrazolodiazepines. Scope and limitations.

Leonid G. Voskressensky 1*, Roman S. Borisov2

1 Russian People’s Friendship University, 6, Miklukho-Maklaia St., Moscow 117198, Russia; 2 A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Science, 29, Moscow 119991, Leninsky ave., Russia

A novel efficient method for the synthesis of heteroannulated [1,4]benzodiazepines via an isocyanide-based multicomponent reaction was

elaborated. The tetrazolo[1,5-a][1,4]benzodiazepines were obtained by a facile azide Ugi-five-center-four-component reaction (U-5C-4CR)

using ketones, sodium azide, ammonium chloride and corresponding isocyanide (Scheme 1). The aforementioned tetrazolodiazepines

represent a notable class of compounds with proven platelet aggregation inhibitory and cholecystokinin agonist activities. In our approach the

desired tetrazolodiazepines were synthesized by simply mixing 1 mmol of a ketone with 1.2 mmol of sodium azide, 1.2 mmol of ammonium

chloride and 1 mmol of the corresponding isocyanide in aqueous methanol. After 24-48 hours of vigorous stirring at room temperature the

target products precipitated from the reaction mixture

The scope and limitations of this reaction will be discussed.

Scheme 1. Syntheses of compounds 1-19 via U-5C-4CRT

This work was supported by the Russian foundation for basic researches (Grant No. 10-03-00243-a).

Reference

1 Fotso, S Mini-Reviews in Organic Chemistry 2010, 7, 68-74

2 Killam, E. K.; Suria, A. Benzodiazepines. In Antiepileptic Drugs: Mechanisms of Action; Advances in Neurology; Glaser, G. H., Penry, J. K., Woodbury, D. M., Eds.; Raven Press: New York, 1980; Vol. 27, pp 597-615.

Born in 1968 in Moscow, Russia 1992 – B.Sc. in chemistry from the Russian Peoples Friendship University 1994 – M.Sc. in organic chemistry – diploma with honors from the Russian Peoples Friendship University 1999 - Ph.D in organic chemistry - “ Tetrahydropyrrolo[3,2-c]pyridines. Synthesis and reactivity” 2010 – D.Science Organic chemistry 2000 – 2005 – assistant professor at the Organic chemistry department of the RPFU. 2005-2010 – associated professor at the Organic chemistry department of the RPFU 2011 – full professor at the Organic chemistry department of the RPFU Fields of interest – heterocyclic chemistry, bioactivity investigations, new synthetic methods, multicomponent reactions, Medicinal chemistry, NMR.

Fax: (+) 7 4959550779 ; E-mail: [email protected]

O

O

NC

R

O

R1 R2

NH4Cl

NaN3

O

O

NN

NN

R1

R2H2N

-MeOHR

N

NH

N NN

O

R1

R2R

1-19

MeOH\H2O

42


Copper-Cascade Catalysis: Synthesis of 3-Functionalized Indoles

Jing Wang, Jinjin Wang, Yuanxun Zhu, Ping Lu* and Yanguang Wang*


Copper-catalyzed azide-alkyne cycloaddition (CuAAC) was developed and used to construct various compounds with economic and ecological values.1 Meanwhile, the copper-catalyzed Csp3-H activation2 and oxidation consuming oxygen as oxidant3 also attracted considerable attention. We reported herein a novel cascade catalysis strategy to synthesis 3-functionalized indoles via a copper (I)-catalyzed three-component reaction and a sequential copper (II)-catalyzed C-H bond activation and oxidation in oxygen atmosphere. In order to evidence the proposed mechanism, we run the reaction under the argon atmosphere. As we expected, the unoxidative products were isolated. And the unoxidative products could be converted to the oxidative products under the oxygen atmosphere using either Cu(I) or Cu(II) catalyst.

Scheme 1. Copper-catalyzed multicomponent reaction of indoles 1, sulfonyl azides 2 and alkynes 3 under different atmosphere

Reference

1 (a) V. V. Rostovtsev, L. G. Green, V. V. Fokin and K. B. Sharpless, Angew. Chem., Int. Ed., 2002, 41, 2596; (b) C. W. Tornoe, C. Christensen and M. Meldal, J. Org. Chem., 2002, 67, 3057; (c) P. Lu and Y. G. Wang, Synlett, 2010, 165; (d) J. E. Hein and V. V. Fokin, Chem. Soc. Rev., 2010, 39, 1302; (e) E. J. Yoo and S. Chang, Curr. Org. Chem., 2009, 13, 1766.

2 (a) H. R. Lucas, L. Li, A. A. N. Sarjeant, M. A. Vance, E. I. Solomon and K. D. Karlin, J. Am. Chem. Soc., 2009, 131, 3230. (b) Z. Li, C.-J. Li, J. Am. Chem. Soc. 2006, 128, 56; (c) Y. Zhang, C.-J. Li, J. Am. Chem. Soc. 2006, 128, 4242.

3 (a) C. Zhang and N. Jiao, J. Am. Chem. Soc., 2010, 132, 28; (b) S. Chiba, L. Zhang and J. Y. Lee, J. Am. Chem. Soc., 2010, 132, 7266; (c) O. Basle´, C.-J. Li, Green Chem. 2007, 9, 1047; (d) Y. Shen, M. Li, S. Wang, T. Zhan, Z. Tan, C.-C. Guo, Chem. Commun. 2009, 953.

2007: B.S. (Chemistry), Zhejiang University, Hangzhou, China

2007-present: Ph.D. (Organic Chemistry), Zhejiang University, Hangzhou, China


43


Concise Approaches to H-Pyrazolo[5,1-a]isoquinolines

Zhiyuan Chen, Xingxin Yu, Shengqing Ye, Shaoyu Li, and Jie Wu*

Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China

Large collections of small molecules are in great demand in drug discovery programs, which are used to look for lead structures from biological assays. Thus, the pursuit of practical and efficient approaches for rapid generation of natural product-like compounds is of utmost urgency and importance.1 Recently, we have successfully prepared a small library of H-pyrazolo[5,1-a]isoquinolines via cascade reactions.2 Some of these compounds showed promising activities as CDC25B inhibitor, TC-PTP inhibitor, and PTP1B inhibitor from the preliminary biological assays.

NNHR3

R1

R2

NR1

N

MeO2C CO2Me

R2

R3

DMAD, I2

R1 N

R2

N

R3

AgOTf

CC 2009

ASC 2009

R3

[Pd], R3M

R1

R2

CHO O

N

R2

R3

R1

N

O

R3R4 R4

AgOTf

CC 2010

N

R2

NHTs

R3

COOMeR3 CHO

R1AgOTfIPr

MeOH

CC 2010

R3

OSiEt3

N

R2

R4R1

N

R4R3

AgOTfNa2CO3

JCC 2010

R3

O

R4

RNHNH2

AgOTf

ASC 2010

R3

O

N

R2

R4

R1

N

R4R3

ROHOR

AgOTf, KOH

OL 2010

N

R3

R4

R4R1 N

N

R2

R3 Ag(I)Cu(II)

air

OL 2011

R3

N3 SO2R4

R1 N

R2

N

R3 NHSO2R4

AgOTfCuBr

OL 2011

Scheme 1. Generation of Diverse H-Pyrazolo[5,1-a]isoquinolines

Reference

1 (a) Walsh, D. P.; Chang, Y.-T. Chem. Rev. 2006, 106, 2476. (b) Arya, P.; Chou, D. T. H.; Baek, M.-G. Angew. Chem. Int. Ed. 2001, 40, 339. (c) Schreiber, S. L. Science 2000, 287, 1964.

2 Li, S.; Luo, Y.; Wu, J. Org. Lett. 2011, 13, 4312 and references cited therein.

Jie Wu, Professor of Chemistry at Fudan University. Research Interests: Diversity-Oriented Synthesis of Natural Product-Like Compounds via Tandem Reactions. Awards and Others: Thieme Chemistry Journals Award (2010); Editorial Advisory Board, ACS Combinatorial Science.

Fax: (+) 86 21 6564 1740; E-mail: [email protected]

44


Microwave-Assisted Oxo-IMDA Cycloaddition of Amide-Tethered 1,3,8-Nonatrienes

Jinlong Wu,*,a Zejun Jia,a Xiuqing Jianga and Wei-Min Daia,b

a Laboratory of Asymmetric Catalysis and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, China

b Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China

In the process of our study on total synthesis of cytochalasin Z8, we attempted to synthesize the amide-tethered nonatriene 1 for intramolecular Diels–Alder cycloaddition via Wittig olefination of the unsaturated ketone 2. We found that ketone 2 underwent the intramolecular oxygen-hetero-Diels–Alder reaction (oxo-IMDA) (Figure 1).1 We found that a similar substrate 3 (R = 3-ClC6H4) could form the cycloadducts under controlled microwave heating. But the major adduct 4b was found not stable under heating to produce an unexpected ring-opening product 4a The product distribution was found temperatue-dependent. The reaction carried out at 100 ºC for 0.5 h afforded three adducts in a ratio of 12:83:5 (4a:4b:4c). Alternatively heating at 180 ºC for 0.5 h afforded the adducts in a ratio of 89:0:11 (4a:4b:4c). The adducts’ strcutres are assigned on the basis of spectroscopic data.

N

Me

Me

O

PMB

Ph

O

RN

PMBO

Me

O

RH

PhH

NO

MeO

Me

H

Ph

PMB

H

R

H

+

NO

MeO

Me

H

Ph

PMB

H

R

H

CH3CN

N

Me

Me

PMB

Ph

O

CO2Et N

Me

Me

O

PMB

Ph

O

CO2Et

4a 4b 4c3

+

R = 3-ClC6H4

1 2

MW, 100-180 oC

0.5-1.0 h

Figure 1. Microwave-assisted intramolecular oxo-Diel–Alder reaction of 3.

References

1. (a) Murray, W. V.; Mishra, P. K.; Sun, S.; Maden, A. Tetrahedron Lett. 2002, 43, 7389–7392. (b) Murray, W. V.; Mishra, P. K.; Turchi, I. J.; Sawicka, D.; Maden, A.; Sun, S. Tetrahedron 2003, 59, 8955–8961.

Acknowledgement. This project is supported by the National Natural Science Foundation of China (Grand No. 20572092).

Prof. Jinlong Wu, Department of Chemistry, Zhejiang University

Fax: (+86) 571-87953128 ; E-mail:[email protected]

45


Microwave-Assisted Rap-Stoermer Reaction for Synthesis of Benzofurans

Jinlong Wu,a Weiwei Han,a and Wei-Min Dai*,a,b



Ugi four-component reaction (Ugi-4CR) is one of the powerful tools to access structural complexity.1 Moreover, the Ugi-4CR adducts are transferable into various cyclic scaffolds via post-Ugi transformations which allow a facile access to a number of medicinally relevant heterocycles. Among them, benzofuran structural moiety is present in numerous biologically active natural products. We report here on synthesis of benzofurans 3 via microwave-assisted Rap-Stoermer reaction of the linear dipeptide-like Ugi-4CR adducts (Figure 1).1,2 The reactions of 1 with the salicyaldehydes 2 were performed in the presence of Cs2CO3 in MeCN under controlled microwave heating at 80–140 ˚C for 15–30 min to directly afford the benzofurans 3 in 43–90% isolated yields. With 3 in hand, two different heterocycles (5,6-dihydrophenanthridines and 2-oxindoles) were readily synthesized by palladium-catalyzed intramolecular direct arylation and intramolecular N-arylation processes.3 The structures have been confirmed by X-ray crystal structural analysis.

R1

NH2

CHO

Br

+

HOBr

O

O N

ONH

R2O

R1

CHO

OH

R

N

O

O

NR2

O

R1

MeOHN

NH

R1

Br

O

R2

Br

O

R2-NC

N

OO

O

NHR2

R1

Br

R

R

R

50 oC, 2 days

2 eq K2CO330 mol% PivOH, DMA

2 eq K2CO3, PhMe

+

2.5 eq Cs2CO3

MW, CH3CN

R = H, 6-OMe, 5-NO2,

5,7-t-Bu2, 5-Cl

R1 = H, Me, Cl, t-Bu

R2 = Cy, Bn, t-Bu, 4-MeOC6H4

1

2

3

4a

4b

R = H, R1 = H,

R2 = cyclohexyl

R = H, R1 = Me,

R2 = benzyl

Figure 1. X-ray structure of 4a

Figure 2. X-ray structure of 4b

10 mol% Pd(OAc)220 mol%, PCy3 -HBF4

10 mol% Pd(OAc)210 mol% BINAP

Figure 1. Ugi four-component reaction of 2-aminophenols and microwave-assisted Rap-Stoermer reaction of 1 with 2.

References 1. Shang, Y. J.; Wang, C.; He, X. W.; Ju, K.; Zhang, M.; Yu, S. Y.; Wu, J. P. Tetrahedron 2010 , 66, 9629–9633. 2. Kumaraswamy, G.; Ramakrishna, G.; Raju, R.; Padmaja, M. Tetrahedron 2010, 66, 9814–9818. 3. (a) Lie´gault, B.; Lapointe, D.; Caron, L.; Vlassova, A.; Fagnou, K. J. Org. Chem. 2009, 74, 1826-1834. (b) Chaudhary, S.; Harding W. W.; Tetrahedron 2011, 67, 569–575. (c) Gorelsky, S. I.; Lapointe, D.; Fagnou, K. J. Am. Chem. Soc. 2008, 130, 10848–10849. (d) Xing, X. L.; Wu, J. L.; Luo, J. L.; Dai, W.-M. Synlett 2006, 2099–2103.



46


Microwave-Assisted IMDA Cycloaddition for Synthesis of Bicyclic -Pentyrolactones

Jinlong Wu,*,a Benguo Lin,a and Wei-Min Daia,b



Intramolecular Diels-Alder (IMDA) reaction is one of the efficient methods for synthesis of bicyclic lactones and it has been extensively studied in recent years. Its applications in total synthesis of natural products have been disclosed.1 Recently, we have reported a number of tandem Wittig–intramolecular Diels–Alder reactions for synthesis of the bicyclic -butyrolactones 1 and 22a,2b and the bicyclic -pentyrolactones 32c (Figure 1). As a continuation of the work, we report here on the microwave-assisted IMDA cycloaddition of ester-tethered 6-methyl-1,3,9-decatriene 4 for synthesis of the bicyclic -pentyrolactones 5 and on the influence of the C6-Me in triene 4 on the diastereoselectivity. The reactions of the trienes 4 were performed in MeCN or PEG-400 under controlled microwave heating at 160–230 ˚C for 2–4 h to afford the lactones 5a and 5b in 75–99% combined isolated yields and in the diastereomer ratios of 67:3392:8 (5a:5b). Details on structural characterization and assignment of stereochemistry of the products are presented.

R1

O R3

OMeR2

O

Me

R1

R2

OH

H

R3

O

Me

R1

R2

O

H

R3

H

O

R4

R1

R2

O

R5

R3

+

R1

R2

O

R4

OR3

R1

R2 R4

OO

R3

MW, 160-230 oC

2-4 h

5a: cis (major) 5b: trans (minor)R1 = Me, Ph; R2 = Me;

R1,R2 = -(CH2)4-

R3 = H, Me, Ph dr: 67:33-92:8; yield: 75-99%

31 2

4

CH3CN or PEG-400

Figure 1. Structures of bicyclic lactones 1–3 and microwave-assisted intramolecular Diels–Alder reaction of trienes 4.

References

1. (a) Takatori, K.; Hasegawa, K.; Narai, S.; Kajigawa, M. Heterocycles 1996, 42, 525–528. (b) Chackalamannil, S.; Davies, R.; McPhail, A.T. Org. Lett. 2001, 3, 1427–1429.

2. (a) Wu, J.; Sun, L.; Dai, W.-M. Tetrahedron 2006, 62, 8360–8372. (b) Wu, J.; Yu, H.; Wang, Y.; Xing, X.; Dai, W.-M. Tetrahedron Lett. 2007, 48, 6543–6547. (c) Wu, J; Jiang, X.; Xu, J.; Dai, W.-M. Tetrahedron 2011, 67, 179–192.

Acknowledgement. This project is supported by the National Natural Science Foundation of China (Grand No. 20572092).



47


Structure Revision and Total Synthesis of (-)-Berkelic Acid

Xiaoxing Wu

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China

An Oxa-Pictet-Spengler cyclization of a fully functionalized ketal aldehyde and a 2,6-dihydroxybenzoic acid stereospecifically constructs

the tetracyclic core of berkelic acid. A Kiyooka aldol condensation of an aldehyde with a trimethylsilyl ketene acetal and the

oxazaborolidinone prepared from N-Ts-(S)-valine gives two of the four possible aldol adducts, which were oxidized and deprotected to

complete the first synthesis of (–)-berkelic acid. This synthesis proceeds with a longest linear sequence of only 13 steps in 2% overall yield,

leading to reassignment of the stereochemistry at C-18 and C-19, assignment of the relative stereochemistry at C-22, and establishment of the

absolute stereochemistry. A biosynthetic pathway is proposed that is consistent with the known absolute stereochemistry at the quaternary

carbon of spiciferone A, spicifernin, and berkelic acid and provides a simple explanation for the differing stereochemistry at C-18 and C-19

of spicifernin and berkelic acid.

Figure 1. Total Synthesis of (–)-Berkelic Acid

Reference

1 Wu, X.; Zhou, J.; Snider, B. B. Angew. Chem. Int. Ed. 2009, 48, 1283.

2 Wu, X.; Zhou, J.; Snider, B. B. J. Org. Chem. 2009, 74, 6245.

3 Buchgraber, P.; Snaddon, T. N.; Wirtz, C.; Mynott, R.; Goddard, T.; Fürstner, A. Angew. Chem., Int. Ed. 2008, 47, 8450.

Dr. Xiaoxing Wu did his graduate study under Professor Yan-Guang Wang’s supervision in Zhejiang University during 2001-2004. After then, he continued his Ph.D. study under the supervision of Professor Barry B. Snider at Brandeis University and obtained the Ph.D. degree in 2009. During 2009-2011, he did the post-doctoral research in Professor Stephen L. Buchwald's laboratory at Massachusetts Institutes of Technology. Dr. Wu was appointed as a Principle Investigator in Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences in Oct. 2011. He has long been engaged in the research on total synthesis and organometallics.

Fax: (+86) 20-32093615; E-mail: [email protected] Homepage ((optional)): http://sourcedb.gibh.cas.cn/zw/zjrc/201109/t20110929_3356719.html

48


Zirconium-mediated Multicomponent Reactions Xiaoyu Yan and Chanjuan Xi*

Department of Chemistry, Tsinghua University, Beijing, 100084, China

The Group 4 metal complexes have attracted considerable attention owing to their fascinating structural features,

their unique M-C bonding, and their unusual capacity to induce highly selective transformation reactions.[1] Among them,

utilization of the 16-electron organozirconocene complexes has been extensively explored.[1,2] However, the utilization

of organozirconate complexes with 18 electrons in organic synthesis has rarely been reported.[3] Recently, we have found

that alkynylzirconates can act as multifaceted reagents to react with varies reagents,[4] for example, (1) reaction with acyl

compounds afforded functionalized allenes; (2) reaction with aldehydes afforded dienols; (3) reaction with

chlorodiphenylphosphine or trimethylsilyl trifluoromethanesulfonate affordedbis(allene). We recently extended this

research program, the results of this study lead to new transformation.

Scheme 1. Zirconium-mediated multicomponent reactions

Reference

1. Marek, E. I. Titanium and Zirconium in Organic Synthesis, Wiley-VCH, Weinheim, 2002. 2. a) Negishi E, Takahashi T. Bull. Chem. Soc. Jpn, 1998, 71: 755. b) Takahashi T, Kotora M, Hara R, Xi Z. Bull. Chem. Soc. Jpn, 1999, 72: 2591. 3. a) Dumond, Y.; Negishi, E. J. Am. Chem. Soc. 1999, 121, 11223. b) Thomas, E.; Dixon, S.; Whitby, R. J. Angew. Chem. Int. Ed. 2006, 45, 7070. 4. a) Yan, X.; Zhou, Y.; Xi, C. Chem. Commun. 2010, 7801. b) Xi, C.; Yan, X.; You, W. Takahashi, T. Angew. Chem. Int. Ed. 2009, 48, 8120. c) Yan, X.; Lai,

C.; Xi, C. Chem. Commun. 2009, 6026. d) Xi, C.; Liu, Y.; Yan, X.; Chen, C. J. Organomet. Chem. 2007, 692, 4612.

Chanjuan Xi, Ph.D. Ph.D. Hokkaido University, Japan 1999 M.S. Lanzhou Institute of Chemical Physics, CAS, 1994 B.S. Lanzhou University, 1986 Assistant Prof. of Chem. Lanzhou Institute of Chemical Physics, CAS, 1986-1995 Postdoctoral Fellow, Catalysis Research Center, Hokkaido University, 1999-2000 Associate Prof. of Chem. Tsinghua University, 2000-2005 Prof. of Chem. Tsinghua University, 2006-Present


49


Zirconocene-mediated 4- or 5-Component Coupling Zhenfeng Xi

College of Chemistry, Peking University, Beijing 100871, China

In 2004, we reported a zirconocene-mediated intermolecular coupling reaction of one molecule of Si-tethered diyne with three molecules of nitriles, which afforded 5-azaindoles upon hydrolysis of the reaction mixture.[1] In 2009, we disclosed that the process integrating all the five components together is very interesting and unpredictable.[2] Very recently, we realized the one-pot synthesis of 5-azaindoles from four different components including three different nitriles and one alkyne.[3] Complicated reactive intermediates were isolated and characterized. Further synthetic applications of these intermediates have also been achieved.

Reference

1 X. Sun, C. Y. Wang, Z. Li, S. Zhang, Z. Xi, J. Am. Chem. Soc. 2004, 126, 7172.

2 (a) W.-X. Zhang, S. Zhang, X. Sun, M. Nishiura, Z. Hou, Z. Xi, Angew. Chem. Int. Ed. 2009, 48, 7227. (b) S. Zhang, X. Sun, W.-X. Zhang, Z. Xi, Chem. Eur. J. 2009, 15, 12608. (c) S. Zhang, W.-X. Zhang, Z. Xi, Chem. Eur. J. 2010, 16, 8419.

3 (a) S. Zhang, W.-X. Zhang, J. Zhao, Z. Xi, J. Am. Chem. Soc. 2010, 132, 14042. (b) S. Zhang, J. Zhao, W.-X. Zhang, Z. Xi, Org. Lett. 2011, 13, 1626. (c) S. Zhang, W.-X. Zhang, J. Zhao, Z. Xi, Chem. Eur. J. 2011, 17, 2442. (d) W.-X. Zhang, S. Zhang, Z. Xi, Acc. Chem. Res. 2011, 44, 541.

Education 1983 B. Sc., Xiamen University, Xiamen, China 1989 Ms. Sc., Nanjing Univ., Zhengzhou Univ., and the Henan Institute of Chemistry, China 1996 Dr. Sc., Institute for Molecular Sciences (IMS), Okazaki, Japan Professional career 1996 Postdoc, Hokkaido University, Hokkaido, Japan 1997 Assist. Prof., Hokkaido University, Hokkaido, Japan 1998 Assoc. Prof., Peking University, Beijing, China 1999 Prof., Peking University, Beijing, China

Fax: (+) 86-10-6275-1708 E-mail: [email protected] Homepage: http://www.chem.pku.edu.cn/xizf/revised/

50


The Development and Application of Cascade Reactions

Peng-Fei Xu

State Key Laboratory of Applied Organic Chemistry, Lanzhou University

Today, amongst the challenges facing synthetic chemists is the development of efficient and elegant chemical processes that allow the rapid creation of molecular complexity and diversity.1 To this end, the field of cascade reaction development - arguably one of the most stimulating, dynamic and synthetically powerful areas in contemporary organic synthesis - is beginning to provide genuine solutions. Herein, we have developed a range of cascade reactions for synthesis of natural products, biologically significant therapeutics and diversity oriented library synthesis.2

N

Ts

Ph

CO2MeMeO2C

OR CF3

R2O2C R1

NH

Ar1

NO2

R NAc

OH

R2OH

R1 R3

O

O N

N

NO2

Ar2

R1

Tos

HO Ar3

N

PMP

CHO

R

R1O2C CO2R1

R2

NO2R3

HO

NR1

O

R2O

OOR2

O

R1

R3

TetrahydropyridinesTetrahydropyridines

Piperidines Cyclohexanes

Furans

Pyrroles

TetrahydroquinolineTetrahydroquinoline

Amaryllidaceae alkaloid

Development ofCascade Reactions

COAr2

NH

NN

R

OBn

Indole alkaloid

Figure 1. The Development and Application of Cascade Reactions

Reference

1 K. C. Nicolaou, D. J. Edmonds, P. G. Bulger, Angew. Chem. Int. Ed. 2006, 45, 7134–7186.

2 a) D. F. Yu, Y. Wang, P. F. Xu, Adv. Synth. Catal. 2011, in press. b) Y. Wang, Y. C. Luo, X. Q. Hu, P. F. Xu, Org. Lett. 2011, 13, 5346-5349. c) Z. X. Jia, Y. C. Luo, P. F. Xu, Org. Lett. 2011, 13, 832-835. d）D. F. Yu, Y. Wang, P. F. Xu, Tetrahedron 2011, 67, 3273-3277. e) Y. Wang, D. F. Yu, Y. Z. Liu, H. Wei, Y. C. Luo, D. J. Dixon, P. F. Xu, Chem. Eur. J. 2010, 16, 3922-3925. f) H. F. Wang, T. Yang, P. F. Xu, D. J. Dixon, Chem. Commu. 2009, 3916-3918. g) Y. Wang, R. G. Han, Y. L. Zhao, S. Yang, P. F. Xu, D. J. Dixon, Angew. Chem. Int. Ed. 2009, 48, 9834-9838. h) R. G. Han, Y. Wang, Y. Y. Li, P. F. Xu, Adv. Synth. Catal. 2009, 350, 1474-1478.

Peng-Fei Xu received his PhD degree in 1998 at Lanzhou University. He then worked as a postdoctoral fellow at National Chung-Hsing University for 2 years. In 2003, he went to Nagoya University (Japan) and worked as a visiting professor (with Prof. Kazuyuki Tatsumi) for one and a half year. He was appointed as vice director in State Key Laboratory of Applied Organic Chemistry in 2001 and promoted to full professor in 2002. Currently, He serves as provost of Lanzhou University and an advisory board member of the Chinese Chemical Community. He was the recipient of the “Award of New Century Excellent Talents in Universities of China” and “Thieme Journal Award 2009”.

Fax: (+86) 09318915557 ; E-mail: [email protected]

51


Multicomponent reactions based on isoquinolinium salts

Hong Hou, Li Hui, Chao-Guo Yan*

College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China.

As one kind of reactive azomethine ylides, heteroaromatic N-ylide has been used extensively in cycloadditions for

the synthesis of the fused heterocycles with a nitrogen at the point of fusion. Heteroaromatic N-ylides such as pyridinium, quinolinium, isoquinolinium methylides are readily available from the alkylation of aza-aroamtic heterocycles and sequential deprotonation reaction. The 1,3-dipolar cycloaddition of heteroaromatic N-methylides with electron-deficient alkynes and alkenes provided a convenient route to novel nitrogen bridged heterocycles such as indolizines and benzo-fused derivatives. Recently we realized that the versatile reactivity and easily in situ formation of azaaromatic N-ylide can be used to design new multicomponent reactions and found some interesting results. Previous work showed that polysubstituted pyridines, cyclopropanes, dihydrofuranes, zwitterionic salts and pyrido[1,2-a]benzimidazole derivatives could be produced efficiently from multicomponent reactions based on heteroaromatic N-ylides.[1,2] In continuation of our efforts to develop new multicomponent reactions we investigate the reactivity of isoquinolinium salts in the reactions and found very interesting results. The tandem reactions of isoquinoline, α-halogenated methylene compounds, aromatic aldehydes and cyanoacetamide give tetrahydropyrrolo[2,1-a]isoquinolines as main products.[3] The corresponding pyrrolo[2,1-a]isoquinolines and dihydropyrrolo[2,1-a]isoquinolines can be obtained directly by controlling oxidation with DDQ. Under similar conditions the tandem four-component reactions involving cyclic 1,3-dicarbonyl compounds such as Meldrum acid, dimedone and barbituric acid gave the zwitterionic salts in high yields with the unprecedented C-4 substitution pattern.

NCN

CONH2

+ArCHO++i: Et3N, ethanol, 50℃

ii: DDQ, r.t.N

NC Ar

EBr

E

E = CO2Et, C6H4NO2-p,

COC6H5, CONEt2

Scheme 1

N

ArCHO, NEt3

NNO2

ArO

O

O

O

NO2

BrNNO2

O

O

O

OArCHO, NEt3

O

OO

OAr

Scheme 2

References

1. (a) C. G. Yan, X. K. Song, Q. F. Wang, et al, Chem. Commun., 2008, 1440; (b) Q. F. Wang, H. Hou, L. Hui, C. G. Yan, J. Org. Chem. 2009, 74, 7403; (c) C. G. Yan, Q. F. Wang, X. K. Song, J. Sun, J. Org. Chem., 2009, 74, 710; (d) Q. F. Wang, X. K. Song, J. Chen, C. G. Yan, J. Comb. Chem. 2009, 11, 1007.

2. (a) J. Sun, E. Y. Xia, Q. Wu, C. G. Yan, Org. Lett. 2010, 12, 3678; (b) Q. F. Wang, H. Li, H. Hou, C. G. Yan, J. Comb. Chem. 2010, 12, 260; (c) Y. Han, J. Chen, L. Hui, C. G. Yan, Tetrahedron 2010, 66, 7743; (d) Y. Han, H. Hou, Q. Fu, C.G. Yan, Tetrahedron 2011, 67, 2313; (e) H. Li, C.G. Yan, Tetrahedron 2011, 67, 2863; (f) J. Sun, E.Y. Xia, R. Yao, C. G. Yan, Mol Divers 2011, 15,115; (g) J. Sun, Q. Wu, E.Y. Xia, C. G. Yan, Eur. J. Org. Chem. 2011, 2981; (h) J. Sun, Y. Sun, E. Y. Xia, C. G. Yan, ACS Comb. Sci. 2011, 13, 436; (i) J. Sun, E.Y. Xia, Q. Wu, C. G. Yan, ACS Comb. Sci. 2011, 13, 421.

Chao-Guo Yan, Yangzhou University (BS 1982, MS, 1984), Nankai University (Ph.D. 1995). Postdoctoral research at Hong Kong Chinese University, Heidelberg University, Northern Illinois University. Since 1995, he started the independent academic career at Yangzhou University. His research fields are synthetic methodology, organometallic chemistry, and supramolecular chemistry. Now his research topics are concentrated on the design of multicomponent reactions for atom-economic synthesis; the construction and applications of multinucleic transition metal complexes, and self-assembly of functionalized cyclotriveratrylenes, carlixarenes and resorcinarenes.

Tel: 0514-87975531; Fax: 0514-87975244; E-mail: [email protected]

52


The Application of Allenic Carbocations in Several Multi-components Reactions

Guangwei Yin, Pinglu* and Yanguang Wang*

Department of Chemistry, Zhejiang University, Hangzhou 310027, China

The allenic carbocations in situ generated from propargylic alcohols were used in several multi-component reactions. With propargylic alcohols and diethyl arylphosphoramides, 4,9-Dihydro-2H-benzo[f]isoindole derivatives and 1,2-Hydroquinolines were synthesized in one step. From propargylic alcohols , 2-butynedioates and

secondary amines, functionalized dihydroazepines could be constructed . In some cases, 2,5-dihydro-1H-pyrrole,2,3-dihydro-1H-pyrrole, and dien-amine were also formed along with the desired dihydro-azepines, depending on the electronic effect and the steric effect of the secondary amines. In the case of primary amines, 2,3-dihydropyridines were formed.

Scheme 1 synthesis of 4,9-Dihydro-2H-benzo[f]isoindole Scheme 2 Synthesis of dihydroazepines

Scheme 3 Diversity of products

Reference

1 Yin, G. W.; Zhu, Y. X.; Zhang, L.; Lu, P.; Wang, Y. G. Org. Lett. 2011, 13, 940

2 Yin, G. W.; Zhu, Y. X.; Lu, P.; Wang, Y. G. J. Org. Chem. 2011, 76, 8922.

Guangwei Yin was born in 1986, Yangxin, Shandong province. He received his BS in Shandong University in 2008. In 2008 he joined professor Yanguang Wang’ s group at Zhejiang University to be a Ph’D since then.

Fax: (+) 15088688645 E-mail: [email protected]

53

1


Palladium-catalyzed Reaction of Olefins with PhI(OAc)2-TBAB System: An Efficient and Highly Selective Difunctional Strategy.

Lei Yu*, Tian Chen and Rong Guo

School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou , P. R. China, 225002

The palladium-catalyzed reaction of olefins with PhI(OAc)2-TBAB system provides a novel,

efficient and highly selective difunctional strategy to introduce bromo and oxygen groups simultaneously. The substitutes on CC bond controlled the regio-selectivity of this reaction, which could be an effective supplement of bromohydroxylations in organic synthesis.

R2

R1 R3

R4

TBAB

Pd(OAc)210 mol%

CH3CN

60 oC

R1

R2

Br

OAc

R4

R3

51-74%

R1, R2 >>R3, R4

Ar

AcO

R3

R4

R1 = Ar, R2 = H

R3, R4≠ Ar

R1, R2 ≠ H

PhI(OAc)2

+

+

52-70%

Br

Besides the regio-selectivity, further investment in our laboratory disclosed that the reacion have high stereo-selectivity, which was directed by the adjancent effect of the catalyst metal with bromide atom.

Ph

RH

H

[M],DIB, TBAB

BrM

Ph

HR

H

M Br

Ph H

H RAcO Br

Ph

RH

H

[M],DIB, TBAB

M

Ph H

HRAcO

syn-addition A, major

Br

anti-addition B, minor

Br

bH

Ph OAcBr

RHa

A, Jab = 5.4 Hz

OAc

Ph bHBr

RHa

B, Jab = 7.2 Hz

References: Yu, L.; Ren, L.-F.; Yi, R.; Wu, Y.-L.; Chen, T.; Guo, R. Palladium-catalyzed reaction of olefins with PhI(OAc)2-TBAB system: An efficient and highly selective difunctional strategy. Synlett, 2011, 579-581.

Dr. Lei Yu was born in Taizhou (Jiangsu province), China at the year of 1982. He graduated from Nanjing University in 2003 and joined Prof. Xian Huang’s group to start his Ph. D at the same year. He received his Ph. D in 2008 from Zhejiang University, China. On August 2008, Dr. Yu began his career in Yangzhou University as a faculty. He was authorized to be a master supervisor in 2010 and was promoted to be a vice professor in 2011. Dr. Yu’s group is interested in the development of Green Chemistry, including the design and preparation of Green catalyst as well as high atom economical synthetic methodologies. Up to now, Dr. Lei Yu has published 22 articles in the international SCI journals.

Fax: (+) ; 0514－87975244 E-mail: [email protected]

54


Fluorous Multicomponent Reaction-based Diversity-Oriented Synthesis of Heterocyclic Scaffolds

Wei Zhang Deptartment of Chemistry, University of Massachusetts Boston, USA

Fluorous chemistry provides a new solution-phase technology for parallel and high-throughput synthesis of compound libraries. In the development of new diversity-oriented synthesis, we have employed fluorous multicomponent reaction (F-MCR) to assemble heterocyclic scaffolds. One of the starting materials attached to a fluorous linker is used as the limiting agent. The fluorous component is readily isolated from the reaction mixture and used for post-MCR modifications. The fluorous linker is removed by displacement or cyclization reactions to increase substitution and skeletal diversities. The high synthetic efficiency is achieved by atom economic MCR, high speed microwave reaction, and easy fluorous solid-phase extraction (F-SPE). In addition, the fluorous linker may have multiple functions: 1) to protect a functional group, 2) to introduce a fluorous separation phase tag, and 3) to activate a functional group for metal-catalyzed coupling reactions. This presentation summarizes the utility of F-MCRs such as Ugi, Biginelli, Pictet-Spengler, Bienayme-Blackburn-Groebke, and [3+2] cycloaddition followed by Suzuki, de-Boc cyclization, and other linker cleavage reactions to synthesize diverse heterocyclic scaffolds.

Reference

1. Ding, S.; Le-Nguyen, M., Xu, T.; Zhang, W. Green Chem. 2011, 13, 847-849.

2. Lu, Y.; Steven J. Geib, S. J.; Damodaran, K.; Sui, B.; Zhang, Z.; Curran, D. P.; Zhang, W. Chem. Commun. 2010, 46, 7578-7580.

3. Zhang, W. Chem. Rev. 2009, 109, 749-795.

Dr. Wei Zhang is an Associate Professor and the Director of the Center for Green Chemistry in the Department of Chemistry, University of Massachusetts Boston. He received his Ph.D. and did his post doctoral research at the University of Pittsburg. His previous positions include Research Assistant Professor at the University of Pittsburgh, Senior Chemist at DuPont Agricultural Products, and Director of Discovery Chemistry at Fluorous Technologies, Inc. Dr. Wei Zhang is known for his work in the areas of fluorous chemistry, free radical chemistry, and green chemistry. He has published over 130 peer-reviewed papers including 3 Chem. Rev. and 3 Tetrahedron Reports. He is an Associate Editor of Molecular Diversity and an editor of Green Processing and Synthesis.

Fax: (+)617-287-6030 E-mail: [email protected]: http://alpha.chem.umb.edu/faculty/zhang/code/index.htm

NH

N

O R2

O

R1 X

R3

R4

YN

N

HNR3

NR3

O

O

H

H

R1

N

HN

O

OR2

R4

H2NO

O

R

NR3

O

O

H

H

R1

N

N

O R4

O

R2

O

R2

R3

NNH

O

O

R4

R1

NNH

N

O

R2

OR1

N

NR1

R2 S

O R3

XR4

X

R2

R4

R1

R1

N

NR3

O

O

NH

R2

NHN

HO

R2

O H R1CO2Me

R3

X R4

CHOR

O2SORf

Rf

Fluorous animo esters and benzaldehydes for DOS

O NH

XO

X

R1

R2

R3

55

1


A facile and efficient three-component domino reaction of 2-(1-alkynyl)-2-alken- 1-ones with gallium halide and anhydride to multifunctionalized tetra-substituted furans Jinzhong Yao, and Hongwei Zhou*

Department of Chemistry, Zhejiang University, Hangzhou 310007, PR China

Highly substituted furans, as a class of useful compound with potential biological activities and important building

blocks in organic synthesis, a facile and efficient synthetic method for preparation of these compounds is valuable.

Herein we wish to report a three-component domino reaction of 2-(1-alkynyl)-2-alken- 1-ones with gallium halide and

anhydride, which provided a facile protocol to multifunctionalized tetra-substituted furans (Scheme 1).

Scheme 1.

Reference

1. Liu, R.; Zhang J. Chem. Eur. J. 2009, 15, 9303.

2. Xiao, Y.; Zhang, J., Angew. Chem. Int. Ed. 2008, 47, 1903.

3. Yao, T.; Zhang, X.; Larock, R. C. J. Org. Chem. 2005, 70, 7679.

Dr. Hongwei Zhou is originally from Hunan Province, China. He receiveda Master degree in Chemical Engineering from Hunan University (2001) and a Ph.D. degree (2004) from Zhejiang University. After the postdoctoralresearch experience at McMaster University, he joined the faculty of Department of Chemistry, Zhejiang University (2005).

Fax: (+86) 571-88920271; E-mail: [email protected] Homepage: http://mypage.zju.edu.cn/en/zhouhw

O R1

+ (R2CO)2O + GaX3

DCMO

R1

X

R2

O

X = Cl, Br, I

56

1


(Enantioselective Multciomponent Reactions) Jieping Zhu

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN, CH-1015 Lausanne, Switzerland

The field of catalytic enantioseletive transformations has blossomed into a mainstay of chemistry. While many reactions can currently be run with high yields and high enantioselectivities, there remains progress to be made in terms of reaction efficiency, atom economy and environmental safety. One direction that can potentially combine all these concepts is the development of enantioselective multicomponent reactions (MCRs).1 Indeed, MCRs are intrinsically connected to sustainable chemistry and are highly valuable for creating molecular diversity and complexity. In this presentation, we will detail our recent work on the development of enantioselective three-component Povarov reaction as well as four-component enantioselective Mannich-type reaction.2

(0.025 equiv)

CH2Cl2, 0 °C

+ArNH2 R1CHO

CbzHN

RNH

R1

NHCbz

R2

R2+

PO O

OHO

*

Reference 1 Reviews on enantioselective MCRs: (a) Seayad, J.; List, B. Catalytic Asymmetric Multicomponent Reactions; in “Multicomponent reaction” Zhu, J.;

Bienaymé, H., Eds.; Wiley-VCH, Weinheim, 2005, pp 277-299. (b) Guillena, G.; Ramón, D. J.; Yus, M. Tetrahedron: Asymmetry 2007, 18, 693-700. (c)

Gong, L-Z.; Chen, X.-H.; Xu, X.-Y. Chem. Eur. J. 2007, 13, 8920-8926. Enantioselective domino process: (d) D. Enders, D.; Grondal, C.; Hüttl, M. R. M.

Angew. Chem. Int. Ed. 2007, 46, 1570-1581.

2 Liu, H.; Dagousset, G.; Masson, G.; Retailleau, P.; Zhu, J. J. Am. Chem. Soc. 2009, 131, 4598-4599. Dagousset, G.; Drouet, F.; Masson, G.; Zhu, J. Org. Lett.

2009, 11, 5546-5549. Dagousset, G.; Zhu, J.; Masson, G. J. Am. Chem. Soc. 2011, 133, Accepted.

Jieping Zhu received B. Sc from Hangzhou Normal University and M.Sc. degree from Lanzhou University under the guidance of Professor Li Yulin. He got his Ph.D. degree in 1991 from University Paris XI, France under the supervision of Professor H.-P. Husson and Pr. J. C. Quirion. After 18 months post-doctoral stay with Professor Sir D. H. R. Barton at Texas A & M University in USA, he joined CNRS, France in December 1992. He was promoted to Director of Research 2nd class in 2000 and then 1st class in 2006. In September 2010, he moved to “Swiss Federal Institute of Technology Lausanne (EPFL) as a full professor.

Fax: (+) ; int code + 41 6939741 E-mail: [email protected] Homepage: http://lspn.epfl.ch

57


Tandem Reaction involving N-sulfonyl allenamide Yuanxun Zhu, Ping Lu*, and Yanguang Wang* Department of Chemistry, Zhejiang University, Hangzhou 310027, China

Allenamides, as a subclass of allenes, have shown impressive synthetic potentials in organic chemistry. Many reactions based on allenamides were well established in the past decades, such as [4 + 2] cycloadditions, [2 + 2] cycloadditions and radical cyclization. The attendance of an allenamide motif enhances the diversity of reaction possibility. In the formation of cyclic compounds, the allenamide serves as

nucleophilic reagent to undergo catalyzed cyclization with another electrophilic center such as organohalides. More importantly, due to the electron-rich central carbon which can be easily activated in the presence of an electrophile and the unique geometry of allenamide, these reactions often proceed efficiently in highly stereoselective control, thus providing an attractive tool for the stereoselective synthesis of cyclic molecules.

Scheme 1. Tandem Reaction involving N-sulfonyl allenamide

Reference

1. Wei, L.-L.; Xiong, H.; Hsung, R. P. Acc. Chem. Res. 2003, 36, 773. 2. Zhu, Y. X.; Yin, G. W.; Hong, D.; Lu, P.; Wang, Y. G. Org. Lett. 2011, 13, 1024. 3. Zhu, Y. X.; Wen, S.; Yin, G. W.; Hong, D.; Lu, P.; Wang, Y. G. Org. Lett. 2011, 13, 3553.

Yuanxun Zhu was born in Zhejiang, China in 1986. He reveived his B.S. (2009) degree from Zhejiang University. From 2009 to present he did research with Professor Yanguang Wang and Ping Lu at Department of Chemistry, Zhejiang University as Ph.D. candidate. His major interest was focused on multi-component reaction via N-sulfonyl allenamide intermidiate.


58

1


Ruthenium (II)-Catalyzed One-Pot Synthesis of 1-Amidoalkyl-2-naphthols

Xiaoyan Zhu, and Yong Rok Lee*

School of Chemical Engineering, Yeungnam University, Kyongsan 712-749, Korea

A simple, efficient, and direct procedure for the preparation of amidoalkyl naphthols has been developed

by one-pot multi-compoment condensations of 2-naphthol with aryl aldehydes and urea or amides, in the

presence of dichlorotris(triphenyl-phosphine)ruthenium(II) as a catalyst. The reactions were carried out in

refluxing toluene (Scheme 1).

OH

+ +RuCl2(PPh3)3

tolueneOH

NHCOR2R1reflux

R1CHO R2CONH2

Scheme 1

Reference

1. Srihari, G.; Nagaraju, M.; Murthy, M. M. Helv. Chim. Acta. 2007, 90, 1497.

2. Das, B.; Laxminarayana, K.; Ravikanth, B.; Rao, R. B. J. Mol. Catal. A: Chem. 2007, 261, 180.

3. Patil, B. S.; Singh, R. P.; Surpur, P. M.; Samant, S. D. Ultrason. Sonochem. 2007, 14, 515.

4. Khodaei, M. M.; Khosropour, R. A.; Moghanian, H. Synlett. 2006, 916.

5. Kantevari, S.; Vuppalapati, N. V. S.; Nagarapu, L. Catal. Commun. 2007, 8, 1857.

6. Shaterian, H. R.; Amirzadeh, A.; Khorami, F.; Ghashang, M. Synth. Commum. 2008, 38, 2983.

7. Vaghei, G.; Malaekehpour, S. M. Cent. Eur. J. Chem. 2010, 8, 1086.

((Biographical Sketch))

2010.9---2012.8 M.S course at Yeungnam University, Korea

2006.9---2010.6 B.S Shanghai University, China

Fax: (+)82-053-810-4361 ; E-mail: [email protected]

Homepage ((optional)):

59

Author Index

Author Page Author Page

Irini Akritopoulou-Zanze 1 Renata Riva 29

Andrea Basso 2 JARED THOMAS SHAW 32

Xiaopeng Chen 3 Yang Shen 33

Thierry Constantieux 4 Heebum Song 34

Wei-Min Dai 5 Shi-Kai Tian 35

Alexander Dömling 6 Julia Titova 36

Wenhao Hu 8 Shu-Jiang Tu 37

Ali Reza Kazemizadeh 9 Erik Van der Eycken 38

Jonghoon Kim, 10 Johan Van der Eycken 40

Ja Young Koo 11 Alexey V. Varlamov 41

Yong Rok Lee 12 Leonid G. Voskressensky 42

Ming Lei 13 Jing Wang 43

Jian Li 14 Jie Wu 44

Xin Li 15 Jinlong Wu 45

Yao Li 16 Xiaoxing Wu 48

Xufeng Lin 17 Chanjuan Xi 49

Gang LIU 18 Zhenfeng Xi 50

Cheng Ma 19 Peng-Fei Xu 51

Maxim A. Mironov 20 Chao-Guo Yan 52

Thomas J. J. Müller 21 Guangwei Yin 53

Hiroki Oguri 22 Lei Yu 54

Michael G. Organ 23 Wei Zhang 55

Romano V.A. Orru 24 Hongwei Zhou 56

Seung Bum Park 25 Jieping Zhu 57

Nikolai M. Przheval’skii 27 Yuanxun Zhu 58

Hongjun Ren 28 Xiaoyan Zhu 59

60

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