Thanks! to: Paul Hickson Scott Stubbs Jeff Young Janis McKenna Oliva dela Cruz-Cordero Carlotta...
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Transcript of Thanks! to: Paul Hickson Scott Stubbs Jeff Young Janis McKenna Oliva dela Cruz-Cordero Carlotta...
![Page 1: Thanks! to: Paul Hickson Scott Stubbs Jeff Young Janis McKenna Oliva dela Cruz-Cordero Carlotta Spino The grad tour guides, including Jake Bobowski and.](https://reader036.fdocuments.us/reader036/viewer/2022062806/56649d7e5503460f94a60e6c/html5/thumbnails/1.jpg)
Thanks! to:Paul HicksonScott StubbsJeff YoungJanis McKennaOliva dela Cruz-CorderoCarlotta SpinoThe grad tour guides, including Jake Bobowski and Lara Thompson
You for coming!
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Biophysics
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Biophysics (also biological physics) is an interdisciplinary sciencethat applies the theories and methods of physics, to questions of biology.
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Wolfgang E. Pauli:“Festkörperphysik ist eine Schmutzphysik.”
“Condensed matter physics is the physics of dirt.”
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“Physics-envy is the curse of biology”-- Joel Cohen (population biologist)
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The dynamics of life
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AND
BND
What quantity can tell us how far a structure is from folded?
Should be a geometrical quantity depending only on the 2 structures considered.
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We generalize the treatment of distance between points to find the distance between any two space curves.
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22 2
0 0
[ , ]L T
Nambu GotoS s t ds dt r r r r r
s
r
r
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Applications to proteins.Structures with
, MIN MAXD D
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Gastrulation ina fly embryo
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Why is our head at the anterior? (meaningless)Why is our heart on the left? (meaningful)
Turing (1952), Morphogenesis:
Laws of physics E & M are LR symmetricThe initial distribution of embryos is LR symmetricThe distribution of fluctuations is LR symmetric
why not 50/50?
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Amino acids are chiral!Microscopic chirality macroscopic handedness
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UBC Engineering Physics
Forensic DNA analysis
We invented a way to find as few as 10 molecules of DNA in a glass of water!
Applications: forensics, water safety, cancer detection
Andre Marziali
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Carl Michal – Solid-State NMR of biological materials
Structure-properties-function relationships
Q
Spider silk
Sea-snail (whelk) egg capsule Hagfish slime threads
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Why study biophysics?
• Interesting science questions, interesting systems• Quantitative tools (analytical and computational)
are necessary for solutions, bio is becoming more quantitative.
• Active and relatively new area of research with much opportunity.
• Significant and growing interest in the field.
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Fusion of HIV virus w a cell