Thank you for viewing this presentation. We would like to remind … · 2016. 8. 11. · The forced...
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2016 by the author
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OSCILLOMETRY (FOT and IOS) definition and application
PG11 Assessing respiratory system resistance in children and adults
Prof. Waldemar TOMALAK
Dept. Physiopathology of Respiratory System,
Institute for TBC & Lung Dis. Rabka Branch, Poland
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I declare no conflict of interest related to thispresentation
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The forced oscillation technique• Introduced in 1956 by A. DuBois and coworkers:
„Oscillatory mechanics of the lung and chest in man” J. Appl. Physiol. 1956; 8:587-594.
• The forced oscillation technique uses external pressuresignals (generated by loudspeaker) to evoke flowresponse of the respiratory system. Pressure and resulting flow are then analysed yielding to parametersof oscillatory mechanics (resistances and reactances orparameters of the model of respiratory system).
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The forced oscillation technique – twoapproaches
• „classic” (FOT) – with the excitation wavebeing the sum of several sinusoidal waves
• Impulse oscillometry (IOS) – using pressurepulses
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The forced oscillattion technique – the principle
Z – respiratory impedance; R – resistance; X - reactance
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Multifrequency oscillations
………….
Typical frequency range: 2..4 – 32 Hz
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„classic” FOT realisations
Pulmosfor (SEFAM)
Ros (Sensormedics)
Cosmed
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The measurements• Oscillatory measurement are distorted by the so called
upper airways shunt (influence of the impedance of the cheeks and mouth floor). Therefore, the subjecthas to support cheeks with palms during the measurements.
• Interesting modification was put into practice with PULMOSFOR (SEFAM, F) where the pressure wave was applied around the head rather than at the mooth (the head generator technique) to minimize this.
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Head generator of PULMOSFOR
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Analysis of data
Data can be interpreted as values resistance or reactance at given frequency (e.g. R10, X10) or using a simple model of respiratory system with frequency dependent resistance Rrs, compliance od respiratory system Crs and respiratory system inertanceIrs. Resonant frequency Fn is a frequency where Xrs equals 0
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Correlation of FOT indices with classicmeasurements
W. Tomalak et al. Pneumonologia i Alergologia Polska, 1995
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Reference values for FOT
Many publications; especially for children. For different age ranges. Some examples:
• Solymar L et al. Pediatric Pulmonology 1985; 1; 134-140.
• Helinckx J. Eur. Respir J. 1998; 12:438-443
• Mazurek H et al. Pediatric Pulmonology 2000; 30: 47-55.
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Reference values for FOTAdults: • E. Oostven et al. Respiratory impedance in healthy
subjects: baseline values and bronchodilator response.ERJ 2013, 42:1513-1523.
• Age range: 18-80; frequency range: 4-26 Hz; number of subjects: 368.
• Suggestion: „new reference equations based on different setups are recommended to replace those established with a single device.”
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IOS
Present on the market since 1994 – launched by Jaeger company (Vogel J, Smidt U. Impulse oscillometry. Frankfurt: PMI Verlagsgruppe; 1994.)
The realisation of measurements using IOS (impulse oscillometry system) usespressure pulses instead of sum of several sinusoidal waves.
The analysis of data is the same as in classic FOT realisations .
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IOS – the measuring head
loudspeaker
pneumotach
V’ Pm
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An example of IOS measurement
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IOS
• The data are analysed as resistances and reactances at different frequencies (5, 10, 15, 20, 25, 35 Hz)
• The results may be also analysed with built-in 7-element model (not frequently used)
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Correlation of IOS indices with classicmeasurements
Correlation of R5 with FEV1: r=-0.66 (the same study)
W. TOMALAK et al. Pediatric Pulmonology 2006.
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Reference values for children (IOS)
B. Nowowiejska, W. Tomalak et al. Pediatric Pulmonology 2008
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Reference values for adults (IOS)
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ERMonograph 31, 2005
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Reliability of FOT (IOS) data
• As natural breathing may interfere with excitationpressure waves (especially in lower frequencies) a coherence function values (calculated from power spectra of flow and pressure signals) arecalculated for each frequency of interest. The value of coherence is within 0 and 1; the higherthe value the ‚better’ is the measurement.
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Reliability of FOT (IOS) data
• It is assumed that for classic measurementsthe value of coherence should be 0.95 to have the coefficient of variation of impedancedata <10% (Landser et al., 1976.)
• For IOS coherence >0.6 at 5 Hz is anacceptable threshold (Smith et al., 2005.)
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Difference between IOS and FOT (n=79 subjects)f = 5 Hz f = 10 Hz f = 20 Hz
RIO
S[
hPa
-1ls
]
(RPULM + RIOS)/2 [ hPa-1ls ]
RIO
S-
RP
ULM
[ h
Pa-1
ls ]
RPULM [ hPa-1ls ]
J. Radliński, W. Tomalak et al. Comparison of measuring system used to evaluate input respiratory impedance by forced oscillation technique – pilot studyEur. Respir. J 2002; 20; suppl 38; 32
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Difference between FOT and IOS
f
5
10
20
0.82 (***)
0.81 (***)
0.74 (***)
Correlation
0.56 ± 0.91
0.37 ± 0.65
0.22 ± 0.55
0.24 (*)
0.24 (*)
0.16 (NS)
0.16
0.17
0.12
differenciesmean±sd R slope
BA graphs
R
The analysis showed high correlation between PULMOSFOR and IOS resistances; but also systematic differences at lower frequencies, which can be attributed to differencesin pressure signal energy.
J. Radliński, W. Tomalak et al. Comparison of measuring system used to evaluate input respiratory impedance by forced oscillation technique – pilot studyEur. Respir. J 2002; 20; suppl 38; 32
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Oscillometric measurements in obstructive diseases
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Impedance data in obstructive diseases.
DA Kaminsky. Resp Care 2012; 57:85-96
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IOS (FOT) allows measurements of inspiratory and expiratory resistances
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Main advantages of FOT and IOS
• Requires only passive cooperation (natural breathing)
• Fast, easy to perform and reproducible
• Useful especially in children (from 2 yrs of age.), olderadults and patients unable to perform spirometry
• Useful in bronchodilator tests and bronchial challenges
• Standardisation documents
• Allows analysis of respiratory resistance in real time
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Performance of IOS/FOT in youngestchildren
• IOS: Own experience: among 133 children aged3-4 years, 6 were unable to perform the measurements; 27 refused to make examination. Overall cooperation succes rate: 61%
• Spirometry: (also own experience) age group 3-4 yrs. Cooperation yielding to interpretable results: 3.6%
Nowowiejska B et al. Pediatric Pulmonology 2008.Tomalak W et al. Pneumonologia i Alergologia Polska 2008
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IOS (FOT) in assessing small airwayproperties
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Bickel S et al. Chest 2014; 146:841-847
AX and the difference R5-R20 areregarded as small airway status indices
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R5-R20/R5 15% 33% 39% 44%
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277 persons aged 65-97 yrs; 197 with obstruction(FEV1/FVC<LLN)
(R5-R20)/R5 in patientswithout obstruction:
33%
(R5-R20)/R5 in patients with obstruction (mainly COPD)
50.7%
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Application of IOS (FOT)• COPD;• Asthma• Bronchopulmonary displasia• OSA• Central airways obstruction• Adult interstitial lung diseases• Occupational and environmental exposure• Response to bronchodilators;• Bronchoprovocation testing
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DA Kaminsky. Resp Care 2012; 57:85-96
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To conclude… FOT and/or IOS measurements:• Are fast and easy to perform (for the patient, as well as
for the technician)• Need only passive cooperation (tidal breathing)• Are reproducible (although variability is greater than in
spirometry, is comparable to other techniques of respiratory resistance measurements)
• Can be used in bronchodilator and bronchoprovocationtests
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To conclude…
• Can be used in patients from 2..3 years of age up to 100 or more (?)
• There exist several reference values sets (much morefor children than for adults) for both approaches
• There exist recommendation for performing measurements (ERJ 2003; ERM 2005)
• Offers new possibilities for studying respiratory physiology and pathology
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LIMITATIONS
• Much less popular (than spirometry for exampleaccording to Cosmed representative >50 RESMONs sold (excluding US); on the other hand, according to Jaeger representatives, >9500 IOS devices were sold throughout the world)
• Difficult theoretical background
• Different models used; not completely verified
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THANK YOU FOR YOUR ATTENTION