Thalassemia case presentation by Allan
-
Upload
dr-rubz -
Category
Health & Medicine
-
view
817 -
download
9
Transcript of Thalassemia case presentation by Allan
![Page 1: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/1.jpg)
Allan Sia Group 3
![Page 2: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/2.jpg)
Name: Mohd Hafizan Age: 12 Gender: Male Address: Kuala Berang
Reason for visit: Blood transfusion
![Page 3: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/3.jpg)
Known case of HbE Thalassaemia since 11 mths old
Presented with pallor and abdominal distention and less active baby
Admitted to HSNZ Ward 6EF, stayed 11 days and investigations carried out
1st transfusion: 11 months Initial frequency: once a month 2 years old: 3 weekly Each time transfusion volume from 450-600
cc
![Page 4: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/4.jpg)
6 years old: splenectomy done in HSNZ. No complication. Given injection once a month.
Regular follow up monthly in HSNZ. Complication of Blood transfusion:
• Hepatitis C positive • Blood transfusion reaction twice. (red spots all
over body) • Abscess on dorsum of right hand due to
cannulation during blood transfusion in 2003.
![Page 5: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/5.jpg)
• Iron Chelation Therapy – Started at 8 years old, – Overnight 8 hours– Desferral 1500 mg ,5 times per week– Injected by mother– No complication of iron chelation therapy
• no visual problem• No hearing problem• No allergy• No skin infections
• L1 (deferiprone) – Started 3 months ago – 3 times/ day
![Page 6: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/6.jpg)
• Musculoskeletal : – no joint pain– No fracture – no myalgia
• CNS– No headache
• Genitourinary– No change in urine colour– No urinary symptoms
• Endocrine– No polyuria– No polydipsia– No polyphagia– Growth normal
![Page 7: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/7.jpg)
Hepatitis C positive Admission to OPD for blood
transfusion every 3 weeks No other medical illness
![Page 8: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/8.jpg)
No consanguineous marriage between parents
![Page 9: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/9.jpg)
Birth history• Antenatal uneventful • Perinatal: fetal distress 2 to poor maternal
effort, emergency LSCS done • Admitted to ward for 1 week
Developmental miles stones • normal since childhood• Studying in SK Sungai Buloh • Weak in studies• Height- no discrepancy with friends
Immunization – up to age
![Page 10: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/10.jpg)
Drug history – NO additional supplements, no known drug allergy
Diet History – reduced red meat intake
Social History• Has many friends, able to play football • No social problem • Poor socioeconomic status, on social
support. • Father odd jobs worker, mother
housewife.
![Page 11: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/11.jpg)
General Appearance•Alert and conscious•Not in respiratory distress•Thin •Frontal bossing of head, maxilla overgrowth•Dark skin
![Page 12: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/12.jpg)
General examination•Pallor•Capillary refill time normal•No cyanosis•No clubbing•No jaundice•No lymph node enlargement•No pedal edema•No flapping tremor
![Page 13: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/13.jpg)
• Pulse rate: 72 bpm• RR: 16• BP: 118/74 mmHg• Temperature: afebrile • Weight: 26kg• Abdomen: soft, non tender. Transverse scar seen
over the left lumbar region approx 13cm, well healed no tenderness. Hepatomegaly 4cm below the right costal margin.
• CVS: no raise JVP, no features of HF, S1S2 heard, no murmur.
• Resp: vesicular breath sounds heard in all lung field
![Page 14: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/14.jpg)
• Provisional Diagnosis: HbE Thalassaemia with hepatitis C
• Points for diagnosis: • Diagnosed when 11 months of age• Short transfusion interval• Parents found to be carrier• Another sibling also diagnosed with Thalassaemia
and another with trait• Splenectomy done at 6 years old • Hepatomegaly 4cm below the right costal margin • Chipmunk facies
![Page 15: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/15.jpg)
Full blood count Blood film Reticulocyte count Electrophoresis Red cell phenotyping HLA
![Page 16: Thalassemia case presentation by Allan](https://reader033.fdocuments.us/reader033/viewer/2022061407/555e061ed8b42a99188b465f/html5/thumbnails/16.jpg)
Full blood count • Last result (September)
WBC count: 61.6 x 10^9/L Platelet: 563 x 10^9/L Hb level: 6.32 g%
Liver function test • Albumin: 42 g/L• Globulin: 37 g/L• Alkaline phosphatase: 169
IU/L• Alanine transferase: 56 IU/L• Bilirubin: 31 umol/L
HIV, Hepatitis B and C screening • HIV non reactive• Hepatitis C reactive
Ferritin • Last result: 2493 ug/L
(September)