Texts in Slides C - USAHA · Texts in Slides Veterinary Services Animal and Plant Health Inspection...

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Veterinary Services Animal and Plant Health Inspection Service

U.S. Department of Agriculture

Update on the National Bio and

Agro‐Defense Facility:FADDL

Diagnostic Priorities

Kimberly Dodd, DVM, MS, PhDCommittee on Foreign and Emerging DiseasesVeterinary ServicesUSDA, APHIS

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National Bio and Agro‐Defense Facility (NBAF)

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NBAF Construction Fully Funded

• Funding appropriations began in FY06 to start planning and the site selection process.

• The $1.25 billion acquisition cost was fully funded in FY15 through a combination of federal appropriations and funding provided by the State of Kansas.

• $938M federal appropriations.

• $312M Kansas funding.

• $5M City of Manhattan

The NBAF acquisition includes costs to complete construction and facility commissioning

NBAF Construction Fully Funded

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Construction on Schedule

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NBAF will be a Government Owned and Government Operated (GOGO) facility

Drawing on 60+ years’ experience with PIADC

New opportunity to draw in private sector talent

Federal staff will direct management, operations, and research support

U.S. government has full control over the facility

Will promote international/federal agency collaborations

Roughly 400 personnel will staff NBAF when fully operational

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Veterinary Services Animal and Plant Health Inspection Service 6


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Mission: Foreign Animal Disease Diagnostic Laboratory (FADDL)

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Serve as a reference laboratory for:• U.S. National Animal Health Laboratory

Network (NAHLN)• United Nations Food and Agriculture

Organization (FAO)• World Organization for Animal Health (OIE)

National Veterinary Services Laboratories in Ames, IA (above) and Plum Island, NY (right)

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FAD Investigations: FADDL trains veterinarians

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FAD Investigations: FADD School back in session

Foreign Animal Disease Diagnostician Courses at Plum Island Animal Disease Center (PIADC)

FY 2019•112 participants trained

• 56 federal veterinarians• 46 state veterinarians• 10 military veterinarians

FY 2020•Courses this year

• Four – 2‐week courses• One – 1‐week course

• Federal, State and Military Veterinarians

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Expanding the FADDL Mission at NBAF

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NBAF Diagnostic Mission Enhancements

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Expand ability to develop and validate diagnostics for new and emerging diseases

Expand capability to meet the increasing needs of the NAHLN

Improve necropsy facilities for training more veterinarians to detect FADs

Enhance international collaborations and training efforts in FAD-endemic countries

Increase epidemiologic capacity to monitor worldwide disease trends and prioritize threats to prepare for emerging disease outbreaks

Establish a robust reagents program and stockpile –the Biologics Development Module

Strengthen support for potential forensics needs

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Veterinary Services Animal and Plant Health Inspection Service 12

Standing up the FADDL Expanded Mission at NBAF

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African Swine Fever (ASF): A FADDL Diagnostic Priority

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https://sciencemag.org

http://www.asianews.it/files/img/China‐_African_swine_fever.jpg

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African Swine Fever (ASF): A FADDL Diagnostic Priority

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http://www.asianews.it/files/img/China‐_African_swine_fever.jpgEarly detection is critical!

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ASF: A FADDL Diagnostic Priority


http://www.asianews.it/files/img/China‐_African_swine_fever.jpg• Suspect case: – An animal having clinical signs and epidemiological

information consistent with ASF. • Presumptive positive case:

– A suspect case with a positive screening laboratory test result for ASFV (PCR) at NVSL FADDL, or

– At a NAHLN laboratory approved for ASF Preparedness and Surge Testing.

• Confirmed positive case: – An animal from which ASF virus has been isolated

and identified at NVSL FADDL or a laboratory designated by the Secretary of Agriculture or,

– A presumptive positive case with a positive confirmatory ASFV antigen test at NVSL FADDL.

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ASF: A FADDL Diagnostic Priority



• Support expansion of NAHLN capacity• Support expansion of CSF/ASF surveillance plan• Enhance antigen detection capabilities

• Enhance sequencing capabilities – completed• Virus isolation: evaluate alternate cell types/preparations• Evaluation of aggregate sample types (oral fluids) - ongoing• Evaluation of commercially available PCR kits – ongoing

• Enhance antibody detection capabilities• Validation of confirmatory test (IPT) – completed• Comparison of commercially available kits - ongoing• Development of in-house ELISA for antibody detection - ongoing

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ASF: Enhanced sequencing capabilities



O’Donnell et al., 2019.

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ASF: Oral fluids (OF) evaluation



Collaboration with Canadian Food Inspection Agency

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• Overview of FADDL’s ASF diagnostic testing procedures

• Clinical evaluation of ASF infected pigs• Necropsy demonstration of ASF infected pigs• Keynote: ASF Outbreak in China

• Collaboration between NVSL‐FADDL and the Department of Homeland Security (DHS) and NVSL‐ NAHLN

• Representatives from 32 NAHLN Laboratories participated

• Incident Command System 300 training• ASF table top exercise‐ laboratory focused

ASF Outbreak Laboratory Response Course on Plum Island

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Thank you

Kimberly Dodd, DVM, MS, PhDDirectorForeign Animal Disease Diagnostic LaboratoryVeterinary ServicesUSDA, APHIS

Texts in Slides C - USAHA · Texts in Slides Veterinary Services Animal and Plant Health Inspection...

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