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![Page 1: Text WHO Global Influenza Programme NIC Role during a pandemic and NIC contingency plan Wenqing Zhang MD Global Influenza Programme, WHO HQ THE 3rd MEETING.](https://reader035.fdocuments.us/reader035/viewer/2022062719/56649ec85503460f94bd452d/html5/thumbnails/1.jpg)
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WHO Global Influenza Programme
NIC Role during a pandemic and
NIC contingency plan
Wenqing Zhang MDGlobal Influenza Programme, WHO HQ
THE 3rd MEETING OF NATIONAL INFLUENZA CENTRES IN THE WESTERN PACIFIC AND SOUTH EAST ASIA REGIONS
18-20 August 2009 • Beijing China
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Epidemic and Pandemic Alert and Response - WHO Global Influenza Programme
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WHO Global Influenza Programme
NIC TOR– Stable for long-term, "glue" and "lubricant" of a Network
• Seasonal influenza surveillance and support to WHO vaccine virus process• Detection of emerging virus
– Minimum technical requirement to become a GISN member
NIC Role in monitoring and responding to the threat of human influenza– Precise roles of NICs during all the different stages of pandemic preparedness and
response– WHO recommendation - implementation depending on national authorities– NOT to replace NIC TOR
NIC Contingency plan development guidance– Guidance to prepare for pandemic response
Laboratory surveillance and response guidelines during a pandemic – under development
– Guidance to respond during a pandemic
- A package for NICs -
Key GISN documents related to NICs
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WHO Global Influenza Programme
NIC role during a pandemic
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Epidemic and Pandemic Alert and Response - WHO Global Influenza Programme
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WHO Global Influenza Programme
Pandemic preparedness and response phases
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Epidemic and Pandemic Alert and Response - WHO Global Influenza Programme
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WHO Global Influenza Programme
Structure of recommendation of NIC role
Consistent with the WHO guidance: Pandemic Influenza Preparedness and Response
– Planning and coordination
– Situation monitoring and assessment
– Reducing the spread of disease; and
– Communications.
All recommended activities intended to continue in higher phases unless replaced
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Epidemic and Pandemic Alert and Response - WHO Global Influenza Programme
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WHO Global Influenza Programme
During a period of high alert – WHO phase 4
Definitions– Phase 4: H-2-H transmission able to sustain at community-level
• Not necessarily mean a pandemic is to take place
NIC objectives– Early detection of novel virus infection in humans
• Geographically – assisting the decision making of rapid containment• If rapid containment operation undertaken, enhanced surveillance in place
– Assisting WHO and national authorities on:• Pandemic risk assessment • Development/update of vaccine viruses, diagnostics etc
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Epidemic and Pandemic Alert and Response - WHO Global Influenza Programme
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WHO Global Influenza Programme
Planning and coordination– Affected countries
• Rapid containment– Whether or not to mount– If yes, assisting national authority an enhanced surveillance system
• Ensuring continuity of lab surveillance– Sampling strategy developed, reviewed, adjusted– Selection criteria developed jointly with WHO for sending representative specimens
to CCs during rapid containment operation
– All countries• Implementation/adjustment of surge capacity plans• Reviewing lab diagnostic strategy• Be aware of and taking actions to any new WHO surveillance criteria• Measures in place to protect lab workers
During a period of high alert – WHO phase 4
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Epidemic and Pandemic Alert and Response - WHO Global Influenza Programme
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WHO Global Influenza Programme
Situation monitoring and assessment
– Affected countries• Testing and sharing of specimens
– Representative cases for testing: time sequential; symptom; geographical location; potential epi history …
– Testing; characterization; alert to variant – Timely shipping all/selective specimens/virus isolates to WHO CCs
• Supporting the effective clinical management of infection– Continuing monitor susceptibility of antivirals to emerging virus strains– Rapid sharing of information significant of public health with WHO and national
authorities
– All countries• Assistance to national authorities - systematically organizing specimen testing• Advice to the country on lab testing algorithms and surveillance criteria• Testing specimens from all suspected cases
During a period of high alert – WHO phase 4
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Epidemic and Pandemic Alert and Response - WHO Global Influenza Programme
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WHO Global Influenza Programme
During a pandemic – WHO phases 5-6
Definitions– Phase 5: novel virus established H-2-H transmission at community level
in at least 2 countries in one WHO region
– Phase 6: in addition, at least one other country in another WHO region
NIC objectives– Affected countries
• Assisting national authorities on mitigating pandemic impact• Monitoring the evolution of the novel virus
– Countries not yet affected• Support detection of start of a pandemic to trigger interventions
– All countries• Assisting WHO and national authorities on:
– Pandemic risk assessment – Development/update of vaccine viruses, diagnostics etc
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Epidemic and Pandemic Alert and Response - WHO Global Influenza Programme
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WHO Global Influenza Programme
During a pandemic – WHO phases 5-6
Planning and coordination– Review lab components of national plan and implementation as
required
– Periodic review to sustain NIC diagnostic functioning
– Adjustment of sampling/testing strategy
– Be aware of update of guidance on biosafety requirements, specimen collection, storage and transport and selection of viruses to CCs
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WHO Global Influenza Programme
During a pandemic – WHO phases 5-6
Situation monitoring and assessment
– Affected countries• Adjustment of lab surveillance from individual case diagnosis to overall
monitoring • Monitoring the percentages of novel virus and seasonal viruses co-circulating• Adequate surveillance assist WHO/GISN monitoring antigenic evolution and
antiviral susceptibility• Timely sharing representative viruses/specimens with WHO• Timely sharing findings of public health significance with WHO, national
authorities and general public
– Unaffected countries• Update of plans/strategies developed based on gained experience from affected
countries• Maximizing surveillance for rapid detection of first cases
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WHO Global Influenza Programme
After a pandemic
Unknown of one wave or multiple waves
NIC objectives– Review and recovery
• Rebuilding NIC capacity, immediately
• Ready for "next" wave
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Epidemic and Pandemic Alert and Response - WHO Global Influenza Programme
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WHO Global Influenza Programme
After a pandemic Post-peak period
– Continuing virological surveillance to support WHO on:• Percentage of novel virus detections among all influenza virus circulating
• Vaccine virus update
• Antiviral susceptibility
• Diagnostics update
• Pandemic risk assessment
– Capacity restore
– Gap/lesson/experience review
– Possible research studies
Possible new wave
– Same as that for phases 5-6
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Epidemic and Pandemic Alert and Response - WHO Global Influenza Programme
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WHO Global Influenza Programme
After a pandemic Post-pandemic period
– Same as that for post-peak period
• In particular on the proportions of circulating influenza viruses – which will become seasonal influenza viruses …
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Epidemic and Pandemic Alert and Response - WHO Global Influenza Programme
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WHO Global Influenza Programme
Summary – NIC role NICs most likely the primary source of expertise in surveillance and response to
influenza epidemics and pandemics
Triggering many of the well-planned interventions depending on NICs' effective functioning
– Proved by the recent H1N1 event
GISN – WHO coordinated efforts on laboratory/virological surveillance, preparedness and response
– Significant contribution to response to routine and emerging influenza problem
– NICs are the backbone
NIC role in all different phases interlinked
Influenza, at its core, a virus problem– Respect to science and nature
– Working as a team globally
Science and knowledge – key to success
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WHO Global Influenza Programme
NIC contingency plan
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WHO Global Influenza Programme
Why a NIC contingency plan
Lab response/service - a key and indispensible component of overall national/global response
Significantly increased level of demand for lab service expected
– … and proved by recent response
– Most likely exceed routine NIC operations
Ensuring effectiveness and continuity of NIC functioning
– Political and institutional commitment needed
– Coordination from high-level e.g. from MoH
Need planning in advance
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WHO Global Influenza Programme
How to develop a NIC contingency plan
Assessment on anticipated surge level that will be put on the NIC
Identification of the actions and resources needed to establish and maintain the required "surge capacity"
– Ensuring the availability of premises, staff and equipment
– Stockpiling supplies
– Testing strategies, protocols and algorithms
– Lab biosafety and transport of specimens
– Data management
– Communication
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WHO Global Influenza Programme
Ensuring the availability of premises, staff and equipment
Availability of lab and office space– Extra lab and office needed during a pandemic
• Helpful to transfer lab diagnostic technologies to other labs– Additional freezer space needed during a pandemic– If BSL3 lab available, priority reserved for flu-related work
Availability of trained staff– Adequate training in advance– Engaging workers in other labs possibly– Less-well-trained staff could assist with task e.g. tracking specimens, preparing specimen
collection kits etc– NIC to keep a full list of available staff and their relevant training– A plan of work shifts and backup personnel in place– Medical surveillance plan in place
Equipment– Should have a back-up power source– Other back-up equipment e.g. biosafety cabinet, PCR machines, incubators either purchased in
advance or sourced from other labs– Increased storage capacity– NIC to keep an updated inventory of all lab equipment
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Stockpiling supplies
Stockpiling reagents
– Not all have long shelf life, and delivery of supplies might be long lead-time
– In general, a stockpile sufficient for at least 3 months of current NIC activity could be a good strategy
– NICs may wish to establish networks and reach agreement on the exchange of reagents in order to meet short needs
Stockpiling of/access to antiviral drugs
– In coordination with MoH/occupational health
Stockpiling of PPE
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WHO Global Influenza Programme
Testing strategies, protocols and algorithms
Testing strategy
– should be based on national strategies for pandemic surveillance and the capabilities and resources of the lab
– Lead-up and early stages, every specimens to be tested
– While virus widespread, selection criteria for specimens to be tested should be established and applied
Testing protocols
– Each protocols must be thoroughly validated before being put into routine use
– To be agreed upon with epidemiologists and network members
Testing algorithms
– In line with national and global pandemic surveillance strategies
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WHO Global Influenza Programme
Laboratory biosafety and transport of specimens
Lab biosafety and biosecurity
– Biosafety cabinet
– Understanding and training on practice at appropriate biosafety levels
– Seasonal vaccination among lab workers
Transport of specimens in-country
– Possible disruption of or refusal by routine transport system
– SOP in place with coordination from high level national authorities
Transport of specimens to reference labs and WHO CCs
– WHO guidelines on specimens/virus shipping followed
– International transport arranged according to IATA regulations
– Import/export permits obtained in advance
– Personnel handling shipping trained
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WHO Global Influenza Programme
Data management
Conventional filing of forms and results– At the very minimum and essential
– and be maintained to provide back-up if electronic systems down
Electronic systems– Best use existing systems to avoid additional duplicated work
– As simple as possible to keep key information
– Remaining possibility to expand the system
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WHO Global Influenza Programme
Communications
Successful NIC response has to be team work
A robust communication network established in advance– MoH, national lab network, WHO, WHO CCs, NICs, other partners
GISN communication platform for timely and informal communications
FluNet reporting – lab surveillance findings
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Summary – NIC contingency plan
Lab surge capacity is anticipated and inevitable
The better planned/prepared,
– the less chaos in a lab handling pouring in specimens and under pressing stress
– the better continuity of NIC quality service
Individual NICs individual plans
Commitments from MoH and host institution is key
"NIC contingency plan" not just another document
– Reassurance to success of national and global pandemic response
– Protection of NIC staff – precious asset of a country
Take actions!
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