1. Testing the impact of online brain training in promoting wellbeing and resilience Dr Justine Gatt Senior Research Fellow Brain Dynamics Centre University of Sydney Medical School & WMI Westmead

2. The Problem 3. How to promote wellbeing and resilience? In an effort to promote mental health, mostresearch in psychiatry focuses on understanding mental illness, ways to predict it and treat it However, mental health is not simply the absence of mental illness only 25% commonality! The questions remain: What defines optimal mental health? What defines the flourishing and resilient individual? Can these features be nurtured in people who may be low in resilience and wellbeing using intervention tools such as e-health platforms? 4. The Approach 5. The TWIN-E Study in Emotional WellbeingRecruitmentAustralian Twin Registry: N approached = 9,622 //N double positive response = 2,370 (25%) 1600 twins Phase I 18-65 years, healthy Tested across Australia Web Assessment + DNA saliva kit (N = 1,643) Phase 1 & 2 tested for behavior and brain function MRI/fMRI/DTI EEG Phase 3 involves a RCT N = 270 N = 451 trial to 30-days of Phase II: 12-months MyBrainSolutions cognitive trainingCompleted in Mar 2012Completed in Oct 2013Web Assessment (90% retention)Phase III: e-health RCTTo be completed in early 2014 6. Aim 2: Evaluate efficacy in improving wellbeing & resilience using MyBrainSolutions Games for positivity, stress reduction attention, memoryTools to track and reward yourselfAssessment and Report on your own Brain Profile 7. The Results 8. MyBrainSolutions improves psychological functioning over 30 days 2.4Positive affectDepressed mood3.02.2Control2.8MeanMean2.0 1.8 1.6 1.42.6 2.41.22.21.02.0Time 1Time 2Time 13.9Emotion suppression56.0Social skills55.53.755.0MeanMeanTime 2Pre-Post TreatmentPre-Post Treatment3.53.354.5 54.0 53.53.153.02.952.5 52.02.7Time 1Time 2Pre-Post TreatmentTreatmentTime 1Time 2Pre-Post Treatment 9. Future studies: A new e-health tool developed by Freedomsway Meta-Analysis for individualsVantage Point for organisations 10. Potential Collaboration 11. What I can offer / What I need Collaborators interested in testing thee-health platforms, Brain Resources MyBrainSolutions or Freedomsways Meta-Analysis in their own cohorts Collaborators interested in using our new scales of wellbeing and resilience for use in their own cohorts 12. New measures of wellbeing & resilience COMPAS-W Scale of Wellbeing: 26-item compositemeasure of wellbeing (Gatt et al., in submission) Gatt Resilience Scale (GR-S): sub-item scale defining the ability to maintain flourishing wellbeing despite negative life events (Gatt et al., in preparation) COMPAS-W subscalesExample itemComposureWhen faced with a stressful situation, I make myself think in a way that helps me stay calmOwn-worthKnowing I have done something well is more important to me than being praised by someone elseMasteryI like to have a say in making decisions made by any group I am inPositivityI laugh easily and am a cheerful high-spirited personAchievementI work hard to accomplish my goalsSatisfactionHow satisfied are you with your quality of life 13. Funding: NHMRC CDF Fellowship 1062495 & ARC linkage grant 0883621 NHMRC CDF Fellow Dr Justine Gatt (BDC Sydney) Investigators Leanne Williams (BDC Sydney & Stanford) Peter Schofield (NeuRA) Richard Clark (Flinders) Anthony Harris (BDC Sydney) Industry Partners Brain Resource Ltd Freedomsway Imaging Core Mayuresh Korgaonkar Stuart Grieve PhD students Karen Burton Kaushik Ram Kylie Dowd 14. Thank you!