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Teh Lay Kek

Academic Position: Professor & Deputy Director, Integrative Pharmacogenomics Institute, Universiti Teknologi MARA, Malaysia

Address: Level 7, FF3, Universiti Teknologi MARA Campus Selangor, 42300 Puncak Alam, Selangor Malaysia

Email: tehlaykek2016@gmail.com Researcher ID: Web of Science: ABH-6209-2020 ORCID: 0000-0002-2830-4263 Scopus: 7005663493 EDUCATION Doctor of Philosophy (Pharmacology), 2002, Universiti Sains Malaysia Master of Clinical Pharmacy,1997, Universiti Sains Malaysia B.Pharm. (Hons.),1995, University of Nottingham, UK Professional Registered Pharmacist (Malaysia) EMPLOYMENT Universiti Teknologi MARA (since 2003) Integrative Pharmacogenomics Institute Research Fellow Faculty of Pharmacy Lecturer Sesama Equilab (2001-2002)

Chief Scientist Department of Pharmacy, (1997-2001) Faculty of Medicine, Universiti Malaya Lecturer

RESEARCH AREA / INTEREST 1. Experimental and Clinical Pharmacogenomics 2. Clinical and experimental Metabolomics 3. Precision Health Teaching Area 4. Basic Pathology for Pharmacy. 5. Clinical Pharmacokinetics. 6. Clinical Pharmacy Concept. 7. Research Instrumentation. 8. Metabolomics 9. Pharmacogenomics

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SELECTED ACTIVITIES

1. Founding Member, Pharmacogenomics Centre (PROMISE) (Sept 2008 –) 2. Founding Member, Malaysian Society for the Advancement of Pharmacogenomics 3. Secretary, Malaysian Society for the Advancement of Pharmacogenomics (2004-2006) 4. Vice President & Founding Member, Malaysian Metabolomics Society 5. Adjunct Professor Academy of Science India, Institute Genomics Integrative Biology, India (2014-2016) 6. Article Reviewer for International Journals

Journal of Clinical Pharmacy & Therapeutics, http://mc.manuscriptcentral.com/jcpt , Future Medicine. http://www.futuremedicine.com/, Clinical Chemistry and Laboratory Medicine (CCLM). http://www.degruyter.com/view/j/cclm

7. International Grant Reviewer: National Health Institute, Singapore, 2014 8. Member of Editorial Board, Evidence-Based Complementary and Alternative Medicine, since 2015 9. Task force Committee Member on the Study on the Future Direction for Higher Education in the Institute of Higher

Education in Malaysia – Pharmacy Program, Ministry of Higher Education Malaysia 10. Task Force Committee Member on Relationship of HLAB*1502 with Cutaneous Reaction of Antiepileptic Drugs,

Ministry of Health Malaysia 11. Member of Evaluation and Registration Committee for Pharmacists and Organisation [Jawatankuasa Penilaian Ijazah

dan Pendaftaran Ahli Farmasi dan Pertubuhan Perbadanan (JKIP)], Board of Pharmacy, Ministry of Health Malaysia, 1 Jan 2010 – 1 Jan 2013

RESEARCH FUNDINGS SELECTED RESEARCH GRANTS / FUNDS (2009 – 2019)

1. Principal Researcher. Determinants of executive performance function of the younger generation: understanding the genetic variation of BDNF-TRKB and microRNA regulatory roles. FRGS, MOHE RM 182,800.00. 2019-2022

2. Co-researcher. Secondary metabolites of tacca integrifolia with anti-proliferative properties: factors and mechanisms in regulating the expression of genes to enhance the yield. FRGS, MOE RM 153,700, 2019-2022

3. Co-researcher. Elucidating the regulation of wound healing genes by baeckea frutescens ethanolic extract. RACER, MOE RM 51,200, 2019-2021

4. Co-researcher. Investigating anti-proliferative effect of chalcone derivatives against breast cancer: in silico and in vitro approaches. RACER, MOE RM 51,200, 2019-2021

5. Principal Researcher. Anxiolytic effects of moringa oleifera extract using chronic unpredictable stress zebrafish model. DANA UiTM RM 45,000.00. 2018-2020

6. Principal Researcher. Computational studies on chalcone and flavone derivatives as multi-target inhibitors: towards anti-inflammatory therapy. TRGS, MOHE RM 467,000.00. 2014-2017

7. Principal Researcher Transgenerational epigenetics in substance abuse: exploring the inheritable DNA methylation underlying the agressive behaviour and altered stress response. ERGS, MOHE RM 224,000.00; 2013-2015

8. Principal Researcher. Metagenomics and metabolomics analysis of human gut microbiota: Evaluation of the predisposing mechanisms and probiotic effects on obesity. FRGS, MOE; RM 194,000, 2012-2014

9. Co-researcher. Exploring The Metabolic Regulatory Networks Of Virulence And Resistance Behaviour Of Pathogenic Klebsiella Pneumoniae And Proteus Mirabilis Using Whole Genome. ERGS, MOE RM 146,000, 2012-2014

10. Co-researcher. Evolutionary Genomics and Anthropological Approaches on the Endangered Malaysian Aborigine Populations: Towards Ensuring their Sustainability. LGRS, MOE RM 8,000,000, 2011-2017

11. Co-researcher. Top Down LRGS Program Tropical Tuberculosis: Delineating Host- Environment-Pathogen

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Interactions. LRGS RM 6,000,000. 2011-2014 12. Principal Researcher. Human thromboxane synthase gene (CYP5A1) and glycoprotein IIb/IIIa complex: Implication in

the mechanism of aspirin resistance FRGS, MOE. RM 97,700. 2010-2011 13. Co- Researcher. A whole genome analysis of the adaptive power of S. aureus to antibiotics: emergence of methicillin-

resistant S. aureus (MRSA) FRGS, MOE. RM 87,900, 2010-2011 14. Co- Researcher. Unraveling the molecular mechanism attributing to the ultra-rapid metabolism of CYP2C9 FRGS,

MOE RM 77,500.2010-2011 15. Co Researcher. Expression Analysis Of Thiopurine Methyltransferase (TPMT) Activity In Leukemic Patients eScience,

MOSTI RM 200, 000. 2009-2010 16. Principal Researcher. The Relevance of Genetic Profile in Optimization Drug Therapy for Thiopurine and 5-

Fluorouracils FRGS, MOE. RM 144,4002007-2009 CONSULTATION

1. IBT- Mitomasa. The safety, efficacy and PK of the investigator products for TGT PRIMAAGE (RM 476,073.20) 2. IBT- Mitomasa. The safety, efficacy and PK of the investigator products for APOPTOLIN (RM 100,000) 3. Metabolomics and accurate mass detection using LCMS-QTOF (RM60,000) 4. Quantative analysis of primaquine and metabolites (RM15,000) 5. Personal Genome Analysis with Genecare S/B (RM 50,000)

SELECTED PUBLICATIONS [2009-2020] PUBLICATION 2020

Firus Khan, A.Y, Ahmed, Q.U, Nippun, T.S,Hilles, A, Jalal, T.K, Teh, L.K, Salleh, M.Z, Noor, S.M, Seeni, A, Khatib, A, Wahab, R.A. Determination toxic effects of Hystrix Brachyura Bezoar extracts using cancer cell lines and embryo zebrafish (Danio rerio) models and identification of active principles through GC-MS analysis. Journal of Ethnopharmacology, 2020, 262, 113138

Lim, W.F., Yusof, M.I.M., Teh, L.K., Salleh, M.Z. Significant decreased expressions of CaN, VEGF, SLC39A6 and SFRP1 in MDA-MB-231 xenograft breast tumor mice treated with moringa oleifera leaves and seed residue (MOLSr) extracts. Nutrients, 2020, 12(10), pp. 1-18, 2993

Rizal Husaini Razali,, Rofiee, M.S., Teh, L.K., ...Ibrahim, H.M., Salleh, M.Z. Development and Validation of a High-Performance Liquid Chromatography–Tandem Mass Spectrometry Method for Methotrexate Quantitation in Human Serum. Journal of Analytical Chemistry, 2020, 75(10), pp. 1335-1339

Abdullah, U.Y.H., Ibrahim, H.M., Mahmud, N.B., Salleh, M.Z., Teh, L.K., Noorizhab, M.N.F.B., Zilfalil, B.A., Jassim, H.M., Wilairat, P., Fucharoen, S. Genotype-Phenotype Correlation of β-Thalassemia in Malaysian Population: Toward Effective Genetic Counseling. Hemoglobin, 2020, 44(3), pp. 184-189

Razali, R.H., Noorizhab, M.N.F., Jamari, H., ...Teh, L.K., Salleh, M.Z.Association of ABCC2 with levels and toxicity of methotrexate in Malaysian Childhood Acute Lymphoblastic Leukemia (ALL). Pediatric Hematology and Oncology, 2020, 37(3), pp. 185-197

Abdullah, U.Y.H., Simbak, N., Azzubaidi, M.S., Osman, R., Ibrahim, Jassim, H.M., Yunus, N.M., Johan, M.F., .H.M.. Alwi, Z.B., Teh, L.K., Fakhruzzaman, M.N., Salleh, M.Z. Hyperleucocytosis grading score and NPM1 gene mutation among patients with acute myeloid leukemia: Malaysian experience. Journal

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of Hematopathology, 2020, 13(1), pp. 33-40

Hafiz, Z.Z., Mohd Amin, M.A., Johari James, R.M., Teh, L.K., ...Salleh, M.Z., Adenan, M.I. Inhibitory Effects of Raw-Extract Centella asiatica (RECA) on Acetylcholinesterase, Inflammations, and Oxidative Stress Activities via in Vitro and in Vivo. Molecules, 2020, 25(4), 892

Hisyam Jamari, Mohd Salleh Rofiee , Richard James Johari Mohd Zaki Salleh and Teh Lay Kek. Standardised Extracts Of Moringa Oleifera And Centellaasiatica Enhanced The Antioxidant Activity, Learning Andmemory Effects By Inhibiting Acetylcholinesterase Activity Ind-galactose Induced Ageing Rats. Pertanika J. Sci. & Technol. 28 (1): 293 - 310 (2020) Siti Norhidayah Mohd Amin, Muhd Hanis Md Idris, Manikandan Selvaraj, Siti Norhidayu Mohd Amin, Hisyam Jamari, Teh Lay Kek & Mohd Zaki Salleh (2020) Virtual screening, ADME study, and molecular dynamic simulation of chalcone and flavone derivatives as 5-Lipoxygenase (5-LO) inhibitor, Molecular Simulation, 46:6, 487-496, DOI: 10.1080/08927022.2020.1732961 Zakaria ZA, Kamisan FH, Kek TL, Salleh MZ. Hepatoprotective and antioxidant activities of Dicranopteris linearis leaf extract against paracetamol-induced liver intoxication in rats. Pharm Biol. 2020 Dec;58(1):478-489. doi: 10.1080/13880209.2020.1764058. PMID: 32476526; PMCID: PMC7336992. Omasanggar R, Yu CY, Ang GY, Emran NA, Kitan N, Baghawi A, Falparado Ahmad A, Abdullah MA, Teh LK, Maniam S. Mitochondrial DNA mutations in Malaysian female breast cancer patients. PLoS One. 2020 May 22;15(5):e0233461. doi: 10.1371/journal.pone.0233461. PMID: 32442190; PMCID: PMC7244147. PUBLICATION 2019 Uday Younis Hussein Abdullaha, Hishamshah M. Ibrahimb, Haitham Muhammed Jassimc, Mohamad Zaki Salleh, Teh Lay Kek, Mohd Nur Fakhruzzaman bin Noorizhab, Bin Alwi Zilfalile, Prapin Wilairatf, Suthat Fucharoeng (2019) Relative proteome quantification of alpha, beta, gamma and delta globin chains in early eluting peaks of Bio-Rad variant II® CE-HPLC of hemoglobin from healthy and beta-thalassemia subjects in Malaysia. Biochemistry and Biophysics Reports 18 100635 Yuan Kei Ching, Yit Siew Chin, Mahenderan Appukutty, Vasudevan Ramanchadran, Choo Yee Yu, Geik Yong Ang, Wan Ying Gan, Yoke Mun Chan, Lay Kek Teh, Mohd Zaki Salleh (2019), Interaction of Dietary Linoleic Acid and α-Linolenic Acids with rs174547 in FADS1 Gene on Metabolic Syndrome Components among Vegetarians. Nutrients. 11(7):1686 Uday YH Abdullah, Hishamshah M Ibrahim, Noraesah B Mahmud, Mohamad Z Salleh, Teh L Kek, Mohd NFB Noorizhab, Haitham M Jassim, Iekhsan Othman, Syafiq A Zainal Abidin, Bin Alwi Zilfalil, Prapin Wilairat, Suthat Fucharoen (2019)Quadrupole-Time-of-Flight Mass Spectrometric Identification of Hemoglobin Subunits α, β, γ and δ in Unknown Peaks of High Performance Liquid Chromatography of Hemoglobin in β … Hemoglobin.43(3): 182-187 Zainul Amiruddin Zakaria, Abdul Rahim, Mohammad Hafiz, Rushduddin Al Jufri Roosli, Mohd Sani, Mohd Hijaz, Najihah Hanisah Marmaya, Maizatul Hasyima Omar, Lay Kek Teh, Mohd Salleh (2019) Antinociceptive Activity of Petroleum Ether Fraction of Clinacanthus nutans Leaves Methanolic Extract: Roles of Nonopioid Pain Modulatory Systems and Potassium Channels. https://doi.org/10.1155/2019/6593125 PUBLICATION 2018

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Sridevi Chigurupati, Manikandan Selvaraj, Vasudevan Mani, Jahidul I Mohammad, Kesavanarayanan K Selvarajan, Shaikh S Akhtar, Maharajan Marikannan, Suthakaran Raj, Lay K Teh, Mohd Z Salleh (2018) Synthesis of azomethines derived from cinnamaldehyde and vanillin: in vitro aetylcholinesterase inhibitory, antioxidant and insilico molecular docking studies. Medicinal Chemistry Research 27 (3), 807-816 Geik Yong Ang, Choo Yee Yu, Richard Johari James, Aminuddin Ahmad, Thuhairah Abdul Rahman, Fadzilah Mohd Nor, Syahrul Azlin Shaari, Adzrool Idzwan Ismail, Lay Kek Teh, Mohd Zaki Salleh (2018) A study on the genetic polymorphisms of CYP3A5 among the Orang Asli in Malaysia using a next generation sequencing platform. Annals of human biology 45 (2), 166-169 Elly Ezlinda Abdul Hisam, Mohd Salleh Rofiee, Aina Mardhia Khalid, Ahmad Firdaus Jalaluddin, Mohd Izwan Muhammad Yusof, Muhd Hanis Idris, Salfarina Ramli, Richard Johari James, Wee Jack Yoeng, Teh Lay Kek, Mohd Zaki Salleh (2018) Combined extract of Moringa oleifera and Centella asiatica modulates oxidative stress and senescence in hydrogen peroxideinduced human dermal fibroblasts. Turkish Journal of Biology 42 (1), 33-44 Manikandan Selvaraj, Muhd Hanis Md Idris, Siti Norhidayu Mohd Amin, Mohd Zaki Salleh, The Lay Kek (2018) Identification of dual target anti-inflammatory inhibitors using merged structurebased pharmacophore modelling and docking approach. International Journal of Computational Biology and Drug Design 11 (3), 183-191 Rizal Husaini Razali, Nurul Ain Khoruddin , Hisyam Jamari , Geik Yong Ang, Choo Yee Yu, Richard Johari James, Kok Hoi Teh, Hishamshah Mohd Ibrahim , Lay Kek Teh and Mohd Zaki Salleh (2018) Understanding the Genetic Risk of Childhood Leukemia among the Orang Asli and Malay in Malaysia: Mining the Whole Genome Sequence Database. MJBMB 2, 38 - 42 SA Nazli, SNF Ismail, AZ Razman, YA Chua, AM Al-Khateeb, M Muhammad, LK Teh, H Mohd Nawawi, NS Mohd Nor, AS Ramli, NA Mohd Kassim (2018). Targeted sequencing as a tool for genetic mutations screening for familial hypercholesterolaemia patients in Malaysian population. Atherosclerosis 275 YA Chua, LK Teh, A Al-Khateeb, M Muhammad, SNF Ismail, H Mohd Nawawi (2018). Exome sequencing: A pathfinding molecular analysis for discovery of novel and known familialhypercholesterolaemia-related mutations in malaysian population. Atherosclerosis 275 Md Idris MH, Amin SNM, Selvaraj M, Jamari H, Kek TL (2018) High-Throughput Structure-Based Drug Design of Chalcones Scaffolds as Dual Inhibitor of Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1. J Pharm Sci Emerg Drugs 6:1. doi: 10.4172/2380-9477.1000128 PUBLICATION 2017 CY Yu, GY Ang, V Subramaniam, R Johari James, A Ahmad, ...LK Teh, MZ Salleh (2017) Inference of the Genetic Polymorphisms of CYP2D6 in Six Subtribes of the Malaysian Orang Asli from Whole-Genome Sequencing Data. Genetic Testing and Molecular Biomarkers E Ady, CN Adlia, SM Lim, LK Teh, MZ Salleh, AV Chin, MP Tan, PJH Poi, ...(2017) Metabolomicguided discovery of Alzheimer's disease biomarkers from body fluid. Journal of Neuroscience Research. DOI: 10.1002/jnr.24048 ÁS Lisboa-Neto, AEAS Ribeiro, EF Feitosa, CWS Wanderley, ...LK Teh, MZ Salleh …. (2017) Cocos nucifera Oil Decreases

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Edema and Mechanical Hypernociception Induced by Bothrops jararacussu Venom in Mice. Planta Medica International Open 4 (01), e17-e23 Noor Wahida Ismail Suhaimy, Ahmad Khusairi Noor Azmi, Norhafizah Mohtarrudin, Maizatul Hasyima Omar, Siti Farah Md Tohid, Manraj Singh Cheema, Lay Kek Teh, Mohd Zaki Salleh, Zainul Amiruddin Zakaria. Semipurified Ethyl Acetate Partition of Methanolic Extract of Melastoma malabathricum Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant-Antisecretory-Anti-Inflammatory Action and Synergistic Action of Several Flavonoid-Based Compounds. Oxidative medicine and cellular longevity. 2017 Manikandan Selvaraj, Muhd Hanis Md Idris and Siti Norhidayu Mohd Amin. Mohd Zaki Salleh and Teh Lay Kek. Identification of Dual Target Anti-Inflammatory Inhibitors Using Merged Structure- Based Pharmacophore Modelling And Docking Approach. Int. J. Computational Biology and Drug Design. 2017 Mohd Z. Salleh, Sridevi Chigurupati , Manikandan Selvaraj , Vasudevan Mani , Jahidul I. Mohammad , Kesavanarayanan K. Selvarajan , Shaikh S. Akhtar , Maharajan Marikannan, Suthakaran Raj , Lay K. Teh. Synthesis of azomethines derived from cinnamaldehyde and vanillin: in vitro aetylcholinesterase inhibitory, antioxidant and in silico molecular docking studies. Medicinal Chemistry Research. 2017 PUBLICATION 2016 Geik Yong Ang, Choo Yee Yu, Vinothini Subramaniam, Mohd Ikhmal Hanif Abdul Khalid, Tuan Azlin Tuan Abdu Aziz, Richard Johari James, Aminuddin Ahmad, Thuhairah Abdul Rahman, Fadzilah Mohd Nor, Adzrool Idzwan Ismail, Kamarudzaman Md Isa, Hood Salleh, Lay Kek Teh, Mohd Zaki Salleh (2016). Detection of CYP2C19 Genetic Variants in Malaysian Orang Asli from Massively Parallel Sequencing Data PLoS ONE 11(10): e0164169. doi:10.1371/journal.pone.0164169 Mohd Zaki Farah Naquiah, Richard Johari James, Suraya Suratman, Lian Shien Lee, Mohd Izhar Mohd Hafidz, Mohd Zaki Salleh (2016), Lay Kek Teh.Transgenerational effects of paternal heroin addiction on anxiety and aggression behavior in male offspring. Behavioral and Brain Functions 12:23 DOI 10.1186/s12993-016-0107-y Sridevi Chigurupati, Manikandan Selvaraj, Vasudevan Mani, Kesavanarayanan Krishnan Selvarajan, Jahidul Islam Mohammad, Balaji Kaveti, Hriday Bera, Vasanth Raj Palanimuthu, Lay Kek Teh, Mohd Zaki Salleh (2016). Identification of novel acetylcholinesterase inhibitors: Indolopyrazoline derivatives and molecular docking studies. Bioorganic Chemistry 67, 9-17 Kavitha Thevakumar, Josephine Rebecca Chandren, Guillermo Ignacio Perez-Perez, Eng Guan Chua, Lay Kek Teh, Mohd Zaki Salleh, Jin Ai Mary Anne Tan, Alex Hwong Ruey Leow, Khean Lee Goh, Alfred Chin Yen Tay, Barry J Marshall, Jamuna Vadivelu, Mun Fai Loke, Li Ping Wong (2016). Assessment of Risk and Sero-Prevalence of Helicobacter pylori Colonization among Remote Orang Asli Tribes in Peninsula Malaysia PLoS One 11(7), e0159830 doi:10.1371/journal.pone.0159830 Zainul Amiruddin Zakaria, Farhana Yahya, Siti Syariah Mamat, Nur Diyana Mahmood, Nurhafizah Mohtarrudin, Muhammad Taher, Siti Selina Abdul Hamid, Lay Kek Teh, Mohd Zaki Salleh (2016). Hepatoprotective action of various partitions of methanol extract of Bauhinia purpurea leaves against paracetamol-induced liver toxicity: involvement of the antioxidant mechanisms BMC Complementary and Alternative Medicine 16:175 DOI 10.1186/s12906-016-1110-4 A Sivadas, MZ Salleh, LK Teh, V Scaria (2016). Genetic epidemiology of pharmacogenetic variants in South East Asian Malays using whole-genome sequences The Pharmacogenomics Journal doi:10.1038/tpj.2016.39

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Zainul Amiruddin Zakaria, Amal Syahirah Nur Zainol, Adibah Sahmat, Nurul Izzah Salleh, Azfar Hizami, Nur Diyana Mahmood, Nurliana Nasir, Siti Syariah Mamat, Farah Hidayah Kamisan, Norhafizah Mohtarrudin, Siti Selina Abdul Hamid, Siti Farah Tohid, Lay Kek Teh, Mohd Zaki Salleh (2016). Gastroprotective activity of chloroform extract of Muntingia calabura and Melastoma malabathricum leaves. Pharmaceutical Biology 54 (5), 812-826 Lay Kek Teh, Vinothini Subramaniam, Tuan Azlin Tuan Abdu Aziz, Lian Shien Lee, Mohamed Izwan Ismail, Choo Yee Yu, Geik Yong Ang, Mohammad Richard James Johari, Rose Iszati Ismet, Noor Saadah Sahak, Aminuddin Ahmad, Thuhairah Abdul Rahman, Fadzilah Mohd Nor, SyahrulAzlin Shaari, Mustaffa Omar, Adzrool Idzwan Ismail, Kamarudzaman Md Isa, Hood Salleh, Mohd Zaki Salleh (2016). Systematic characterization and comparison of the CYP2C9 variability of the Orang Asli in Malaysia with 12 populations. Drug Metabolism and Pharmacokinetics 31, 304 – 313 Zainul Amiruddin Zakaria, Mohd Hijaz Mohd Sani, Arifah Abdul Kadir, Lay Kek Teh, Mohd Zaki Salleh (2016). Antinociceptive effect of semi-purified petroleum ether partition of Muntingia calabura leaves. Revista Brasileira de Farmacognosia/Brazilian Journal of Pharmacognosy 26, 408 – 419 Mohd Zakihalani A Halim, Mohammad Maaruf Jaafar, Lay Kek Teh, Mohamad Izwan Ismail, Lian Shien Lee, Yun Fong Ngeow, Norazmi Mohd Nor, Zainul Fadziruddin Zainuddin, Thean Hock Tang, Mohd Nazalan Mohd Najimudin, Mohd Zaki Salleh (2016). Genome sequencing and annotation of multidrug resistant Mycobacterium tuberculosis (MDR-TB) PR10 strain. Genomics data 7, 245-246 Mohammad Maaruf Jaafar, Mohd Zakihalani A Halim, Mohamad Izwan Ismail, Lee Lian Shien, Teh Lay Kek, Ngeow Yun Fong, Norazmi Mohd Nor, Zainul Fadziruddin Zainuddin, Tang Thean Hock, Mohd Nazalan Mohd Najimudin, Mohd Zaki Salleh (2016). Genome Sequencing and Annotation of Mycobacterium tuberculosis PR08 strain. Genomics data 7, 119-120 Lay Kek Teh, Manikandan Selvaraj, Zakaria Bannur, Mohd Ikhwan Mohd Ismail, Hanip Rafia, Wan Chung Law, Sapiah Sapuan, Santhi Puvanarajah, Pakeer Shaik Syed Ali, Mohd Zaki Salleh (2016). Coupling Genotyping and Computational Modeling in Prediction of Anti-epileptic Drugs that cause Stevens Johnson Syndrome and Toxic Epidermal Necrolysis for Carrier of HLA-B* 15: 02. Journal of Pharmacy & Pharmaceutical Sciences 19 (1), 147-160, Tuan Azlin Tuan Abdul Aziz, Lay Kek Teh, Muhd Hanis Md Idris, Zakaria Bannur, Lydiatul Shima Ashari, Adzrool Idzwan Ismail, Aminuddin Ahmad, Kamarudzaman Md Isa, Fadzilah Mohd Nor, Thuhairah Hasrah Abdul Rahman, Syahrul Azlin Binti Shaari, Hamid Jan Jan Mohamed, Nornazliya Mohamad, Mohd Zaki Salleh (2016). Increased risks of cardiovascular diseases and insulin resistance among the Orang Asli in Peninsular Malaysia. BMC Public Health 16:284 DOI10.1186/s12889-016-2848-9 Zainul Amiruddin Zakaria, Tavamani Balan, Ahmad Khusairi Azemi, Maizatul Hasyima Omar, Norhafizah Mohtarrudin, Zuraini Ahmad, Muhammad Nazrul Hakim Abdullah, Mohd Nasir Mohd Desa, Lay Kek Teh, Mohd Zaki Salleh (2016). Mechanism (s) of action underlying the gastroprotective effect of ethyl acetate fraction obtained from the crude methanolic leaves extract of Muntingia calabura. BMC Complementary and Alternative medicine 16:78 DOI:10.1186/s12906-016-1041-0 Lydiatul Shima Ashari, Amal K Mitra, Thuhairah Abdul Rahman, Amlan Mitra, Lay Kek Teh, Mohd Zaki Salleh, Hamid Jan B Jan Mohamed (2016). Prevalence and risk factors of metabolic syndrome among an endangered tribal population in Malaysia using harmonized IDF criteria. International Journal of Diabetes in Developing Countries, DOI 10.1007/s13410-016- 0487-4 JSK Shia, Cannilia Kerine, KL Teh, MZ Salleh, SN Hussin, IN Ismail, NJ Abdul Wahab (2016) Genotyping the Exon 10 of Low-Density Lipoprotein Receptor: Discovery of New Single Nucleotide Polymorphism Regional Conference on Science, Technology and Social Sciences (RCSTSS 2014), 541-547

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Z.A. Zakaria, E.S. Jaios, M.H. Omar, S. Abd. Rahman, S.S.A. Hamid, S. M. Ching, L.K. The, M.Z. Salleh, S. Deny, M. Taher (2016). Antinociception of petroleum ether fraction derived from crude methanol extract of Melastoma malabathricum leaves and its possible mechanisms of action in animal models. BMC Complementary and Alternative Medicine 16:488 DOI 10.1186/s12906-016-1478-1 PUBLICATION 2015 Rofiee MS, , Yusof MIM, Abdul Hisam EE, Bannur Z, Zakaria ZA, Somchit MN, Teh LK, Salleh MZ (2015). Isolating the metabolic pathways involved in the hepatoprotective effect of Muntingia calabura against CCl4-induced liver injury using LC/MS Q-TOF. Journal of Ethnopharmacology 166: pp 109–118 Nornazliya Mohamad, Rose Iszati Ismet, Mohd Salleh Rofiee, Zakaria Bannur, Thomas Hennessy, Manikandan Selvaraj, Aminuddin Ahmad, Fadzilah Mohd Nor, Thuhairah Hasrah Abdul Rahman, Kamarudzaman Md.Isa, Adzrool Idzwan Ismail, Teh Lay Kek, Mohd Zaki Salleh (2015). Metabolomics and partial least square discriminant analysis to predict history of myocardial infarction of self-claimed healthy subjects: validity and feasibility for clinical practice. Journal of Clinical Bioinformatics. DOI: 10.1186/s13336-015-0018-4 P Shaik Syed Ali, Jasmine John, Manikandan Selvaraj, Teh Lay Kek, Mohd Zaki Salleh (2015). Nodamura virus B2 amino terminal domain sensitivity to small interfering RNA. Microbiology and Immunology. DOI: 10.1111/1348-0421.12253 S Aazmi, LK Teh, K Ramasamy, T Rahman, MZ Salleh (2015). Comparison of the anti-obesity and hypocholesterolaemic effects of single Lactobacillus casei strain Shirota and probiotic cocktail. International Journal of Food Science & Technology 50(7): 1589-1597 T Ramanathan, Selvaraj Manikandan, AR.Saranya, Thirugnanasambandam Ramanathan, Krishnan Selvarajan Kesavanarayanan, Teh LK, and Salleh MZ (2015). Identification of Benzoxazolinone Derivatives Based Inhibitors for Depression and Pain Related Disorders Using Human Serotonin and Norepinephrine Transporter as Dual Therapeutic Target: A Computational Approach. International Journal of Drug Delivery 6(4) ZA Zakaria, T Balan, SS Mamat, N Mohtarrudin, LK Teh, MZ Salleh (2015). Mechanisms of gastroprotection of methanol extract of Melastoma malabathricum leaves. BMC Complementary and Alternative Medicine 15 (1): 135 Hartini Yusof, Mohamad Shafiq Aazmi, Ili Ng Abdullah, Teh Lay Kek, Aminuddin Ahmad, Mazlifah Omar, Thuhairah Rahman, Mohd Zaki Salleh (2015). Technology Advancement Enabling the Link of Gut Microbiota with Obesity and Metabolic Disorder. Jurnal Sains Kesihatan Malaysia (Malaysian Journal of Health Sciences), 13(1) : 77-91 Nur Jalinna Abdul Jalil, Zakaria Bannur, A Derahman, O Maskon, Noor Darinah, Hamat Hamidi, Osama Ali Gunasekaran, Mohd Rafizi, Nur Izatul Azreen, Teh Lay Kek, Mohd Zaki Salleh (2015). The Implication of the Polymorphisms of COX-1, UGT1A6, and CYP2C9 among Cardiovascular Disease (CVD) Patients Treated with Aspirin. Journal of Pharmacy & Pharmaceutical Sciences, 18 (3) : 474-483 Zainul Amiruddin Zakaria, Amal Syahirah Nur Zainol, Adibah Sahmat, Nurul Izzah Salleh, Azfar Hizami, Nur Diyana Mahmood, Nurliana Nasir, Siti Syariah Mamat, Farah Hidayah Kamisan, Norhafizah Mohtarrudin, Siti Selina Abdul Hamid, Siti Farah Tohid, Lay Kek Teh, Mohd Zaki Salleh (2015). Gastroprotective activity of chloroform extract of Muntingia calabura and Melastoma malabathricum leaves. Pharmaceutical Biology, 1 -15

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I Izwan, LK Teh, MZ Salleh (2015). The genome sequence of Acinetobacter baumannii isolated from a septicemic patient in a local hospital in Malaysia. Genomics Data, 6:128-129 A.A. Laith, A.G. Mazlan, T.S. Tengku Muhammad, L.K. Teh, M.Z. Salleh and M. Najiah (2015). Metabolomic Investigation of Elizabethkingia meningoseptica Response Challenge with Excoecaria agallocha Leaf Extract. Journal of Pure and Applied Microbiology, Vol. 9 (Spl. Edn. 1): 183-194 PUBLICATION 2014 AR Saranya, S Manikandan, T Ramanathan, KS Kesavanarayanan, LK Teh, MZ Salleh (2014). Phytochemical Screening and In-Silico Investigation of 2-Benzoxazolinone from Acanthus Ilicifolius Linn. as Dual Inhibitors of Cyclooxygenase-2 and 5-Lipooxygenase Enzymes. International Journal of Phytomedicine 6 (3) MY Norfatimah, LK Teh, MZ Salleh, MNM Isa, MN Siti Azizah (2014)Complete mitochondrial genome of Malaysian Mahseer Tor tambroides. Gene 548(2) : 263- 269 ND Mahmood, NLM Nasir, MS Rofiee, SFM Tohid, SM Ching, LK Teh, MZ Salleh, ZA Zakaria (2014). Muntingia calabura: A review of its traditional uses, chemical properties, and pharmacologica l observations. Pharmaceutical Biology 52 (12) :1598 -1623 Z Bannur, LK Teh, T Hennesy, WRW Rosli, N Mohamad, A Nasir, R Ankathil, ZA Zakaria, A Baba, MZ Salleh (2014). The differential metabolite profiles of acute lymphoblastic leukaemic patients treated with 6-mercaptopurine using untargeted metabolomics approach. Clinical biochemistry 47(6) : 427-431 LS Lee, LK Teh, ZF Zainuddin, MZ Salleh (2014). The Genome Sequence of a Type ST239 Methicillin-Resistant Staphylococcus aureus Isolate from a Malaysian Hospital. Standards in Genomic Sciences, 9(3) FH Kamisan, F Yahya, SS Mamat, MFF Kamarolzaman, N Mohtarrudin, TL Kek, MZ Salleh, MK Hussain, ZA Zakaria (2014). Effect of methanol extract of Dicranopteris linearis against carbon tetrachloride- induced acute liver injury in rats. BMC complementary and alternative medicine 14(1) : 123. MHM Sani, M Taher, D Susanti, TL Kek, MZ Salleh, ZA Zakaria (2014) Mechanisms of α-Mangostin-Induced Antinociception in a Rodent Model. Biological Research For Nursing 10.1177/1099800414529648 Z Bannur, MZ Salleh, H Hashim, T Hennessy, MN Azmi, Mh Zailani, P Ramasamy, ZA Zakaria, S Suneet, H Ngow, G Henry, Lk Teh (2014) Metabolomics And Pharmacogenetics Based 5-Fluorouracil Monitoring In Colorectal Cancer Patients. International Journal of Pharmacy & Pharmaceutical Sciences 6(2) LK Teh, Z Bannur, ZA Zakaria, HMH Fazleen, MZ Salleh (2014). Single Nucleotide Polymorphism (SNPs) Analysis of Mu-opioid Receptors (OPRM1) Using Denaturing High Performance Liquid Chromatography (DHPLC) among the Intravenous Drug Users. International Journal of Pharmacy & Pharmaceutical Sciences 6(2) ZA Zakaria, MHM Sani, MS Cheema, AA Kader, TL Kek, MZ Salleh (2014). Antinociceptive activity of methanolic extract of Muntingia calabura leaves: further elucidation of the possible mechanisms. BMC complementary and alternative medicine 14(1): 63 Z Bannur, S Bahaman, MZ Salleh, TL Kek (2014). Pharmacogenomics Based Practice in Malaysia: The Attitude, Knowledge

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and Adoption by the Healthcare Professionals. The International Medical Journal of Malaysia 13 (1) JZ Goh, HS Chiong, A Zuraini, AK Arifah, ZA Zakaria, LK Teh, MZ Salleh, MN Hakim (2014). Rapid spectrophotometric determination, characterization and anti-inflammatory efficacy evaluation of nanoencapsulated diclofenac sodium. Journal of Drug Delivery Science and Technology 24 (4): 361-366 PUBLICATION 2013 L.K. Teh, S. Hamzah, H. Hashim, B. Zakaria, Z.A. Zakaria, Z. Hasbullani, J.K.S. Shia, H. Fijeraid, M.N. Azmi, M.H. Zailani, P. Ramasamy, H. Ngow, S. Suneet AND M.Z. Salleh (2013). Potential of Dihydropyrimidine Dehydrogenase Genotypes (DPYD) In Personalizing 5-Fluorouracil (5-Fu) Therapy Among Colorectal Cancer Patients. Therapeutic Drug Monitoring, 35(5):624-630. doi: 10.1097/FTD.0b013e318290acd2. Azwin Ismail, LK Teh, Ngeow YF, Norazmi MN, Zainuddin F. Zainul, TanG TH, Najimudin N, and MZ Salleh (2013). Draft Genome Sequence of A Clinical Isolate Of Mycobacterium tuberculosis Pr05. Genome Announcement, 1(3): e00397-13. doi:10.1128/genomeA.00397-13. Irma Syakina MZ, LK Teh, MZ Salleh (2013). Draft Genome Sequence of Streptococcus agalactiae. Genome Announcement. 1(3):e00351 -13. doi:10.1128/genomeA.00351 -13 MIH Khalid, LK Teh, LS Lee, ZA Zakaria, *MZ Salleh (2013). Genome Sequence Of Proteus mirabilis Isolated From A Local Hospital. Genome Announcement, 1(3):e00327-13. doi:10.1128/genomeA.00327-13. Zulkifli MH, Teh LK, Lee LS, Zakaria ZA, Salleh MZ (2013). Draft genome sequence of Klebsiella pneumoniae isolate PR04. Genome Announcement 1(4):e00418-13. doi:10.1128/genomeA.00418-13. Mohd Zaki Salleh, Lay Kek Teh, Lian Shien Lee, Rose Iszati Ismet, Ashok Patowary, Kandarp Joshi, Ayesha Pasha, Azni Zain Ahmed, Roziah Mohd Janor, Ahmad Sazali Hamzah, Aishah Adam, Khalid Yusoff, Boon Peng Hoh, Fazleen Haslinda Mohd Hatta, Mohamad Izwan Ismail, Vinod Scaria, Sridhar Sivasubbu (2013). Systematic Pharmacogenomics Analysis Of A Malay Whole Genome: Proof Of Concept For Personalized Medicine. PLoS ONE 8(8): e71554. doi:10.1371/journal.pone.0071554 F. Yahya, S.S. Mamat, M.F.F. Kamarolzaman, A.A. Seyedan, K.F. Jakius, N.D. Mahmood, M.S. Shahril, Z.Suhaili, N. Mohtarrudin, D. Susanti, M.N. Somchit, L.K. Teh, M.Z. Salleh and Z.A. Zakaria (2013). Hepatoprotective Activity of Methanolic Extracts of Leaves of Bauhinia purpurea in Paracetamol-induced Hepatic Damage in Rats. Evidence-based Complimentary and Alternative Medicine 2013(2013): Article ID 636580. DOI: 10.1155/2013/636580 A. Sayyedan, Z. Suhaili, M.N.M. Desa, H.M. Khairi, M.N. Somchit, C.A. Fatimah, L.K. Teh, M.Z. Salleh and Z.A. Zakaria (2013). Review on the Ethnomedicinal, Phytochemical and Pharmacological Properties of Piper sarmentosum. TANG Humanitas Traditional Medicine 3(3): 19.1-19.32. DOI: http://dx.doi.org/10.5667/tang.2013.0002. M.H.M. Sani, M. Taher, D. Susanti, L.K.Teh, M.Z. Salleh and Z.A. Zakaria (2012). α-Mangostininduced Antinociception: Involvement of the L-Arginine/Nitric Oxide/cGMP/PKC/K+-ATP Channel Pathways. Biological Research for Nursing Z.A. Zakaria, M.H. Mohd. Sani, M.F. Mohammat, N.S. Mansor, Z. Shaameri, L.K. Teh, M.Z. Salleh and A.S.Hamzah (2013). Antinociceptive Activity of a Synthetic Oxopyrrolidine-based Compound, ASH21374 and Determination of Its Possible

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Mechanisms. Canadian Journal of Physiology and Pharmacology 91(12):1143-1153 91 (12), 1143-1153 M.I. Mohd. Yusof, M.Z. Salleh, L.K. Teh, N. Ahmat, N.F. Nik Azmin and Z.A. Zakaria (2013). Activity-Guided Isolation of Bioactive Constituents with Antinociceptive Activity from Muntingia calabura L. Leaves Using the Formalin Test. Evidence-based Complimentary and Alternative Medicine. MS-715074 Volume 2013, Article ID 715074, 9 pages http://dx.doi.org/10.1155/2013/715074 S. Hamzah, L.K. Teh, J.K.S. Shia, G. Ahmad, H.S. Wong, Z.A. Zakaria AND M.Z. Salleh (2013). Pharmacogenotyping of CYP3A5 in predicting dose-adjusted trough levels of tacrolimus among Malaysian kidney-transplant patients Canadian Journal of Physiology and Pharmacology 92 (1), 50-57 PUBLICATION 2012 Sani, MH; Zakaria, ZA; Balan, T.; Teh, LK; Salleh, MZ; antinociceptive Activity of Methanol Extract of Muntingia calabura Leaves and the Mechanisms of Action Involved. Evidence-Based Complementary and Alternative Medicine.Volume 2012 (2012), Article ID 890361, 10 pages. doi:10.1155/2012/890361 Vasudevan Mani, Kalavathy Ramasamy, Aliya Ahmad, Siti Norshazwani Wahab, Siti Murnirah Jaafar, Teh Lay Kek, Mohd Zaki Salleh, Abu Bakar Abdul Majeed (2012). Role of Total Alkaloidal Extract from Murraya koenigii Leaves on Oxidative Stress and Cholinergic Pathway in Aged Mice. Phytother Res. 2012 Mar 23. doi: 10.1002/ptr.4676. Fazleen Haslinda Mohd Hatta, L.K. Teh., Anders Hellden, Karin Engstrom Hellgren, Hung Keun Roh, Mohd Zaki Salleh, Eleni Aklillu and Leif Bertilsson (2012). Search for the molecular basis of CYP2C9 metabolism: a positive correlationship between IVS8-109A>T and losartan metabolism in Swedes. Eur J Clin Pharmacol. 2012 vol 68(7), 1033-1042 [Epub ahead of print] DOI 10.1007/s00228-012-10-0 L.K. Teh, N.I. Mohamed, M.Z. Salleh, M. Rohaizak, N.S. Shahrun, J.J. Saladina, H. Roslan, S. Sood, T.S. Rajoo, S.P. Muniandy, G. Henry, H.A. Ngow, U. K.T. Hla and J. Din (2012). Risk of Recurrence in Breast Cancer Patients Treated with Tamoxifen: Polymorphisms of CYP2D6 and MDR1. American Association of Pharmaceutical Scientists, 2012 Mar;14(1):52-9. Epub 2011 Dec 20. Z.A. Zakaria, E.E. Abdul Hisam, M. Norhafizah, M.S. Rofiee, M.N. Somchit, L.K. Teh and M.Z. Salleh (2012). Antiulcer Activity of the Aqueous Extract of Bauhinia purpurea Leaf. Journal of Ethnopharmacology, 137(2):1047-54. L.K. Teh, H. Hashim, Z.A. Zakaria, M.Z. Salleh (2012). POLYMORPHISMS OF UGT1A1*6, UGT1A1*27 AND UGT1A1*28 IN THREE MAJOR ETHIC GROUPS FROM MALAYSIA. Indian J Med Res 136, 62-72 Teh LK, Langmia I M, Fazleen Haslinda M H, Ngow H A, Roziah M J, Harun R, Zakaria A Z And M Z Salleh. (2012) Clinical Relevance of VKORC1 (G-1639A & C1173T) And CYP2C9*3 Among Patients On Warfarin. J Clin Pharm Ther. 2012 VOL 37(2), 232-236. Wan Rosalina WR, L K Teh, N Mohamed, A Nasir, A A Baba, R Yusoff, M Z Salleh (2012). Polymorphism of ITPA 94C>A And Risk of Adverse Effects Among Acute Lymphoblastic Leukemia Patients Treated With 6-Mercaptopurine. J Clin Pharm Ther, 2012 VOL 37(2),237–241. DOI: 10.1111/J.1365-2710.2011.01272.X

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L K Teh, Izuddin A F, Fazleen H M H, Zakaria Z A And M Z Salleh (2012). Tridimensional Personalities And Polymorphism Of Dopamine D2 Receptor Among Heroin Addicts. Biological Research For Nursing 14(2):188-96. doi: 10.1177/1099800411405030. PUBLICATION 2011 Z.A. Zakaria, E.E. Abdul Hisam, M. Norhafizah, M.S. Rofiee, M.N. Somchit, L.K. Teh and M.Z. Salleh (2011). In vivo Antiulcer Activity of the Aqueous Extract of Bauhinia purpurea Leaf. Journal of Ethnopharmacology 137(2) : 1047-1054 Zakaria ZA, Somchit MN, Mat Jais AM, Teh LK, Salleh MZ, Long K. In Vivo Antinociceptive and AntiInflammatory Activities of Dried and Fermented Processed Virgin Coconut Oil. Med Princ Pract. 2011;20(3):231 -6. Epub 2011 Mar 29. DOI: 10.1159/000323756 L K Teh, S H M Dom, Z A Zakaria and M Z Salleh. (2011) A Systematic Review of the Adverse Effects of Tacrolimus in Organ Transplant Patients. African Journal of Pharmacy and Pharmacology. 5(6): 764 – 771 Z A Zakaria, A M Mohamed, N S Mohd Jamil, M S Rofiee, M K Hussain, M R Sulaiman, L K The And M Z Salleh (2011) In Vitro Antiproliferative And Antioxidant Activities Of The Extracts OfMMuntingia Calabura Leaves. The American Journal Of Chinese Medicine, 39(1): 1 –18 Z A Zakaria, M S Rofiee, M N Somchit, A Zuraini, M R Sulaiman, L K Teh, M Z Salleh And K Long. Hepatoprotective Activity of Dried- And Fermented-Processed Virgin Coconut Oil. Evidence-Based Complementary And Alternative Medicine, Volume 2011, Article Id 142739, 8 Pages Zakaria, Z.A., Rofiee, M.S., Teh, L.K., Salleh, M.Z., Sulaiman, M.R., Somchit, M.N. (2011 ) Bauhinia Purpurea Leaves' Extracts Exhibited In Vitro Antiproliferative And Antioxidant Activities. African Journal Of Biotechnology 10 (1), Pp. 65-74 Zahari Z, Teh L K, Ismail R, Razali S M. (2011) Influence of DRD2 Polymorphisms On The Clinical Outcomes of patients With Schizophrenia. Psychiatr Genet. Psychiatr Genet. 21(4): 183–189. doi:10.1097/YPG.0b013e3283437250 N J Yob, S Mohd Jofrry, M M R Meor Mohd Affandi, L K Teh, M Z Salleh And Z A Zakaria. Zingiber Zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, And Pharmacological Uses. Evidence-Based Complementary And Alternative Medicine,Volume 2011, Article Id 543216, 12 Pages Doi:10.1155/2011/543216 ZA Zakaria, MS Rofiee, AM Mohamed, LK Teh, MZ Salleh (2011). In vitro antiproliferative and antioxidant activities and total phenolic contents of the extracts of Melastoma malabathricum leaves. Journal of acupuncture and meridian studies 4(4) : 248-256 M.S. Rofiee, Z.A. Zakaria, M.N. Somchit, Zuraini, A.K. Arifah, L.K.Teh, M.Z. Salleh, K.Long (2011). Involvement of CYP450 system in hepatoprotective activity of Malaysian Agricultural Research and Development Institute (MARDI)-produced virgin coconut oils. African Journal of Pharmacy and Pharmacology Vol. 5(23) : 2526-2536, http://www.academicjournals.org/AJPP DOI: 10.5897/AJPP11.021 M Mohd Yusof, L Teh , M Salleh , Z Zakaria (2011). Antinociceptive activity of Muntingia calabura leaves. Planta Med 2011; 77 - PM38. DOI: 10.1055/s-0031-1282796

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POSTGRADUATE SUPERVISION MSc. SUPERVISION COMPLETED (Includes Co-supervision) -15 Students PhD SUPERVISION COMPLETED (Includes Co-supervision) – 9 students ON-GOING Master (RESEARCH) SUPERVISION (Includes Co-supervision) - 7 students On-Going PhD SUPERVISION (Includes Co-supervision ) – 4 students Patent approved A PCR Genotyping Kit for Detection of UGT1A1*6 and UGT1A1*27” A method for CYP2C9 genotyping and a kit derives thereof , PI 20070175. Patent filed Synthesis and isolation of flavonoid that inhibits targets of inflammatory disorders and therefore useful for use as an anti-inflammatory agent (Your ref: IP.5/3/303/PT / Our ref: PT/6512/UiTM/18) Copyright

• A genotyping kit for HLA-B*15:02, 2014 • IGENME: One Click Away To know Your Genetic Risk (LY2019005096) • War on Obesity: Garcinia Booster Drink for Fit Body(LY2019005093) • No Gluten in HLA-DQ: A genotyping test to screen for risk of glutence sensitivity (LY2019004974) • Genosuccess II – strategize your way to success by knowing your genotype (LY2019004976)

Selected Awards Gold Medal: Mohd Zaki Salleh, Teh Lay Kek, Muhamad Hisyam Jamari, Mohd Nur Fakruzzaman Noorizhab. HLA Genotyping kit for carbamazepine-assocaited adverse drug reaction risk. Invention, Innovation & Design Exposition 2019. UiTM Shah Alam Gold Medal: Mohd Zaki Salleh, Teh Lay Kek, Muhamad Hisyam Jamari, Mohd Nur Fakruzzaman Noorizhab. Promising precision medicine: the point of care genetic guided warfarinisation. Invention, Innovation & Design Exposition 2019. UiTM Shah Alam Silver Medal: Richard Muhammad Johari James, Mohd Zaki Salleh, Teh Lay Kek, Roziah Mohd Janor, Norsuhaila Rosmimi Rosli. Genosuccess II- strategise your way to success by knowing your genotype. Invention, Innovation & Design Exposition 2019. UiTM Shah Alam Silver Medal: Teh Lay Kek, Mohd Zaki Salleh, Richard Muhammad Johari James, Mohd Nur Fakruzzaman Noorizhab, Muhamad Hisyam Jamari. No gluten in HLA-DQ: a genotyping test to screen for risk of gluten sensitivity. Invention, Innovation & Design Exposition 2019. UiTM Shah Alam

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Silver Medal: Teh Lay Kek, Mohd Zaki Salleh, Lim Wai Feng, Mohd Salleh Rofiee, Suriati Mohd Nasir. War on obesity: Garcinia boosted drink for fit body. Invention, Innovation & Design Exposition 2019. UiTM Shah Alam Silver Medal: Nurul Ain Khoruddin, Mohd Zaki Salleh Teh Lay Kek, Mohd Nur Fakruzzaman Noorizhab. iGenMe: one click away to know your genetic risk. Invention, Innovation & Design Exposition 2019. UiTM Shah Alam PECIPTA 2017. Gold Award: Mohd Zaki Salleh, Teh Lay Kek, Ang Geik Yong, Yu Choo Yee, Mohd Nur Fakhruzzaman Norizhab. RT-GeType: Real-time Genotyping Kit for HLA-B*15:02. Persidangan dan Ekspo Ciptaan Institusi Pengajian Tinggi & Antarabangsa (PECIPTA) 2017, 7-9 Oktober 2017, Terengganu. BIMB IIDEX 2017 Grand Award: Invention, Innovation & Design Exposition (IIDEX) 2017, 25-29 September 2017, DATC UiTM Shah Alam BIMB IIDEX 2017 Diamond Award: Invention, Innovation & Design Exposition (IIDEX) 2017, 25- 29 September 2017, DATC UiTM Shah Alam Gold Medal: Mohd Zaki Salleh, Teh Lay Kek, Ang Geik Yong, Yu Choo Yee, Mohd Nur Fakhruzzaman Norizhab. RT-GeType: Real-time Genotyping Kit for HLA-B*15:02. Invention, Innovation & Design Exposition (IIDEX) 2017, 25-29 September 2017, DATC UiTM Shah Alam. Silver Medal: Mohd Zaki Salleh, Teh Lay Kek, Khong Heng Yen, Ahmad Sazali Hamzah, Muhd Hanis Md. Idris, Nyotia Anak Nyokat. Safe and Effective Next Generation Multi-Target Anti- Inflammatory Drugs. Invention, Innovation & Design Exposition (IIDEX) 2017, 25-29 September 2017, DATC UiTM Shah Alam Silver Medal: Teh Lay Kek, Mohd Zaki Salleh, Richard Muhammad Johari James, Suriati Mohd Nasir, Mohd Hisyam Jamari. Obese No More With Garcinia atroviridis: A Halal Oral Formulation. Invention, Innovation & Design Exposition (IIDEX) 2017, 25-29 September 2017, DATC UiTM Shah Alam Bronze Medal: Richard Muhammad Johari James, Mohd Zaki Salleh, Teh Lay Kek, Nur Madilawani Badri, Mohd Zulfadhly Jan Jam. X-Lab Logger: A Smartphone App for Laboratory Management. Invention, Innovation & Design Exposition (IIDEX) 2017, 25-29 September 2017, DATC UiTM Shah Alam Bronze Medal: Mohd Salleh Rofiee, Mohd Zaki Salleh, Teh Lay Kek, Mohd Izwan Mohamad Yusof. Say No to Ageing with TGT PRIMAAGE. Invention, Innovation & Design Exposition (IIDEX) 2017, 25-29 September 2017, DATC UiTM Shah Alam PECIPTA 2016 Gold Award: Mohd Zaki Salleh*, Teh Lay Kek, Mohd Nur Fakhruzzaman Noorizhab, Mohd Salleh Rofiee, and Mohd Shafiq Aazmi. HLA-B*15:02 Genotyping kit: Drug’em Right: Personalized CPF therapy by HLA-B*15:02 Genoyping kit. PECIPTA 2015, 4-6 Dec 2015. KLCC. Bronze Award: Mohamad Izwan Ismail, Mohd Zakihalani A. Halim, Mohd Maaruf Jaafar, Lee Lian Shien, Teh Lay Kek, Mohd Zaki Salleh*. iPROMISE Pro-TASK DETECTION KIT: Simultaneous Pentaplex Detection of Multiple Pathogens. PECIPTA 2015, 4-6 Dec 2015. KLCC.

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IIDEX 2015 Gold Award: Mohd Zaki Salleh*, Teh Lay Kek, Mohd Nur Fakhruzzaman Noorizhab, Mohd Salleh Rofiee, and Mohd Shafiq Aazmi. HLA-B*15:02 Genotyping kit: Drug’em Right: Personalized CPF therapy by HLA-B*15:02 Genoyping kit. Invention, Innovation & Design Expo 2015 (iidex2015) 27-30 April 2015. Gold Award: Mohamad Izwan Ismail, Mohd Zakihalani A. Halim, Mohd Maaruf Jaafar, Lee Lian Shien, Teh Lay Kek, Mohd Zaki Salleh*. iPROMISE Pro-TASK DETECTION KIT: Simultaneous Pentaplex Detection of Multiple Pathogens. Invention, Innovation & Design Expo 2015 (iidex2015) 27-30 April 2015. Gold Award : Tuan Azlin Tuan Abdul Aziz, Elly Ezlinda Abdul Hisam, Noor Syakila Azman, Nur Syakila Mohd Zaki, Teh Lay Kek. MU-K, 4 IN 1 CREAM WITH ANTIBACTERIAL, ANTIOXIDANT, WHITENER AND MOISTURISER FOR YOUR SKIN. Invention, Innovation & Design Expo 2015 (iidex2015) 27-30 April 2015 Silver Award: Mohd Nur Fakhruzzaman Noorizhab, Teh Lay Kek, Mohd Zaki Salleh, Bibi Aishaiah Jan Salamat Rosa Iszati Ismet. iPROMISE P450 Pharmacodiagnostic Kit: Increase Your Confidence In Drug Use. Invention, Innovation & Design Expo 2015 (iidex2015) 27-30 April 2015. Silver Award: Suriati Mohd Nasir, Teh Lay Kek, Bibi Aishaiah Jan Salamat, Mohd Hafidz Mohd Izhar, Mohd Zaki Salleh. GAin Control: Let The Fat Burn. Invention, Innovation & Design Expo 2015 (iidex2015) 27-30 April 2015. Silver Award : Mohd Izwan Mohamad Yusof, Mohd Zaki Salleh, Teh Lay Kek, Siti Norhidayu Mohd Amin & Siti Norhidayah Mohd Amin. Androgia Balm. Invention, Innovation & Design Expo 2015 (iidex2015) 27-30 April 2015. Bronze Award : Farah Naquiah Mohd Zaki, Noor Saadah sahak, Mohd Salleh Rofiee, Teh Lay Kek & Mohd Zaki Salleh. MU-K ANTIBACTERIAL SOAP. Invention, Innovation & Design Expo 2015 (iidex2015) 27-30 April 2015. Bronze Award : Adzrool Idzwan Ismail, Fadli Abdul Razak, Muhammad Asri Azuddin, Mohd Zaki Salleh & Teh Lay Kek. CREATIVE RESEARCH: THROUGH THE LENSES OF PHOTOGRAPHERS. Invention, Innovation & Design Expo 2015 (iidex2015) 27-30 April 2015. Gold Medal. GENOTYPING KIT FOR HLA-B* 1502: Pharmacodiagnostic Tool in Reducing Adverse Drug Reaction. Teh Lay Kek. BioMalaysia 2011. Silver Medal: MDR1 Haplotype detection kit. , Mohd Zaki Salleh, Sharina Hamzah, Teh Lay Kek, Fazleen Haslinda Mohd Hatta. 34th International Exhibition of Invention, New Techniques and Product of Geneva. 6th-10th Apr 2011(MZ Salleh, Sharinah Hamzah, Teh LK) Gold Medal: “A PCR Genotyping Kit for Detection of UGT1A1 Kit in Colon Cancer” NPEXâ di Monroeville Convention Centre, Monoeville, PA, Pittsburgh, US, 2010. (MZ Salleh, Hazwanie Hashim, Teh LK) Gold Medal: INPEX, Pittsburg USA. MZ Salleh, Hazwanie Hashim, Teh LK. PROMISE™ UGT1A1 KIT FOR PHARMACOGENOTYPING OF IRINOTECAN

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Gold Medal: IID 2009, UiTM: PROMISE TPMT Kit for personalized treatment of thiopurine drugs. Mohd Zaki Salleh, Wan Rosalina Wan Rosli, Teh LK, Rosmadi MY, Fazleen HMH, A Rahman A Jamal, Neoh Hui-Min. Silver Medal: PECIPTA 2009: PROMISE TPMT Kit for personalized treatment of thiopurine drugs. Mohd Zaki Salleh, Wan Rosalina Wan Rosli, Teh LK, Rosmadi MY, Fazleen HMH, A Rahman A Jamal, Neoh Hui-Min. Gold Medal: 34th International Exhibition of Invention, New Techniques and Product of Geneva. PharmacoDiagnostic: A simple genotyping kit for human CYP2C9 Bronze Medal: Biotechnology Asia 2005, 16 – 18 Aug 2005, PWTC Kuala Lumpur: Raplex: Rapid Multiplex PCR for Genotyping of CYP2C8 Gold Medal: at IPTA Exhibition. Raplex: Rapid Multiplex PCR Kit for Genotyping of CYP2C8 Best Booth Exhibition at IRPA Seminar 2005, 25-27 Feb 2005, Marriot Putrajaya. IRPA Prioritised Top Down Research: Pharmacogenomics and Drug Metabolism: A Study of Mechanisms and Applications in Clinical Settings. Project 1: Understanding Individual Variations in Drug Responses: Development of Rapid Assays for CYP and NAT2 Genotyping. Best Oral Presentation at The 1st National Colloquium And Workshop In Pharmacogenetics. 1st To 4th April 2004. INFORMM, USM. Heterogeneity Of N-Acetyltransferase 2 Among Malays In Malaysia. WWY Nazirah, HMN Mega, LK Teh, C Waminuddin, MH Hani, Y Ashari, M Aziah, KH Yuen, R Ismail. Second Best Oral Presentation at The 1st National Colloquium And Workshop In Pharmacogenetics. 1st To 4th April 2004. INFORMM, USM. Successful Expression of Recombinant Human CYP2D6 in Escherichia coli . WL. Lee, F.Z. Zainul, Y.D. Muthiah, CE. Ong, LK. Teh, R Ismail.

No. Name Degree (PhD)

1. WAN ROSALINA BINTI WAN ROSLI PhD 2. HAZWANIE BT HASHIM PhD 3. SHARINA BINTI HAMZAH PhD 4. NOR IZWANI BINTI MOHAMED PhD 5. ROSE ISZATI BTE ISMET NAYAN PHD 6. MOHD SALLEH ROFIEE PHD 7. HARTINI YUSOF PHD 8. MOHD SHAFIQ BIN AAZMI PHD 9. SITI NOORAISHAH BINTI HUSSIEN PHD 10. MOHAMAD IZWAN BIN ISMAIL PHD 11. MOHD IZWAN BIN MOHAMAD YUSOF PHD 12. MOHD NUR FAKHRUZZAMAN BIN NOORIZHAB PHD 13. PATIMAH @ FATIMAH BINTI ABDOL LATIF PHD 14. ELLY EZLINDA BINTI ABDUL HISAM PHD

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No. Name Degree

(Master) 1. MOHD KHAIRI BIN ZAHRI@JOHARI MASTER 2. IZUDDIN FAHMY BIN ABU MASTER 3. RIZA AFZAN BINTI ASRI MASTER 4. AINUL ZAHIAH ABDUL RAZAK MASTER 5. FAZLEEN HASLINDA MOHD HATTA MASTER 6. IMMACULATE MBONGO LANGMIA MASTER 7. EBTESAM ALI TAEB BESHNA MASTER 8. MOHD IZWAN BIN MOHAMAD YUSOF MASTER 9. MUHAMMAD HAFIQ BIN ZULKIFLI MASTER 10. NORLEEN MOHAMED ALI MASTER 11. ASBIYATULAIDA BINTI DERAHMAN MASTER 12. RUHIL NADIRAH BT CHE OMAR MASTER 13. MOHAMMAD MAARUF BIN JAAFAR MASTER 14. MOHD ZAKIHALANI BIN A. HALIM MASTER 15. NOOR SAADAH BINTI ISHAK MASTER 16. TUAN AZLIN BINTI TUAN ABDU AZIZ MASTER 17. SITI NORHIDAYAH BINTI MOHD AMIN MASTER 18. SITI NORHIDAYU BINTI MOHD AMIN MASTER 19. SURIATI BT MOHD NASIR MASTER 20. BIBI AISHAIAH BINTI SELAMAT MASTER 21. NOOR SYAKILLA BTE AZMAN MASTER 22. ISNMANURA'IN BINTI IBRAHIM MASTER

On Going

1 2017810384 -RUHISY SYAKIRAH BINTI MOHD RASUL

Main supervisor: Prof. Dr Wong Tin Wui, Co-supervisor: Prof. Dr. Teh Lay Kek

2017

2 W AN ATIYYAH BIN TIAB W AH AB Main supervisor: Assoc. Prof. Dr. Sarina, Co-supervisor: Prof. Dr. Teh Lay Kek

2017

3 NURUL AMIRA BINTI MOHD SAMSUDIN Main supervisor: Assoc. Prof. Dr. Sarina, Co-supervisor: Prof. Dr. Teh Lay Kek

2017

4 Nourul Emmilia Mohd Fazli Main supervisor: Prof. Dr. Teh Lay Kek, Co-supervisor: Prof. Dr. Mohd. Zaki Salleh

UiTM 2017

5 IHSAN SAFWAN BIN KAM ARAZAMAN Main supervisor: Dr. Hasseri, Co-supervisor: Prof. Dr. Teh Lay Kek

2019

18

6 SHARIFAH NURDIYAN A BINTI SYED MOHD BAHKTIAR Main supervisor: Prof. Dr. Rohana Abdul Ghani, Co-supervisor: Prof. Dr. Teh Lay Kek

2019

7 2019144861-MUHAMMAD SHAZLY BIN ROSDY Main supervisor: Prof. Dr. Teh Lay Kek, Co-supervisor: Prof. Dr. Mohd. Zaki Salleh

2019

8 2019655206 -NUR FARHANA BINTI MOHAMED NOOR Main supervisor: Prof. Dr. Teh Lay Kek, Co-supervisor: Prof. Dr. Mohd. Zaki Salleh

2019

19

On-going No. Name Degree

1. MUHD HANIS MD IDRIS Main supervisor: Prof. Dr. Teh Lay Kek, Co-supervisor: Prof. Dr. Mohd. Zaki Salleh PHD

2. RIZAL HUSAINI BIN RAZALI Main supervisor: Prof. Dr. Teh Lay Kek, Co-supervisor: Prof. Dr. Mohd. Zaki Salleh PHD

3. ELIN ELISA BINTI KHAIRU L Main supervisor: Assoc. Prof. Dr. Sarina, Co-supervisor: Prof. Dr. Teh Lay Kek PHD