Tearing Dry vs. Wet vs. Both Kimberly Cockerham, MD, FACS Plastics-Orbit-Neuro-Ophthalmology .
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Transcript of Tearing Dry vs. Wet vs. Both Kimberly Cockerham, MD, FACS Plastics-Orbit-Neuro-Ophthalmology .
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TearingDry vs. Wet vs. Both
Kimberly Cockerham, MD, FACSPlastics-Orbit-Neuro-Ophthalmology
www.CalEyes.com
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Systematic Approach to Tearing
Dry Wet Other
Ocular Surface Eyelid Orbit
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Dry Eye is a Disease of the Lacrimal Functional UnitDry Eye is a Disease of the Lacrimal Functional Unit
1122
3344
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Dry Eye Is Prevalent 2.5 million people in the United States1
A top reason for visits to EyeMDs and Ods Patients often dissatisfied with treatments
Frequent drops inconvenient Limited symptomatic relief Frustrated Want new options
1 Multi-Sponsor Surveys, Inc. The 2005 Gallup Study of Dry Eye Sufferers. 2005.
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Dry Eye Patient Factors Older age Female gender Post-menopausal Tobacco smoking Contact lens wear Prolonged staring (e.g. computer
work)
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Environmental Factors Air Pollution Artificial, forced air Allergens Low humidity
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Medications Antihistamines Antidepressants Antispasmodics Diruetics Oral contraceptives Hormonal therapy
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Disease Related Factors Systemic:
Autoimmune disease (TED) Neurologic disease that reduces blink Vitamin A deficiency
Local: Lacrimal gland infiltration Eyelid malposition, laxity,
lagophthalmos Ocular surface disease
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Lacrimal Glands:Lacrimal Glands:• Chronic irritationChronic irritation• T-cell activationT-cell activation• Cytokine secretion into Cytokine secretion into
tearstears
Interrupted Secretomotor Interrupted Secretomotor Nerve ImpulsesNerve Impulses
Tears Damage Ocular Tears Damage Ocular SurfaceSurface
Cytokines Cytokines Disrupt Neural ArcDisrupt Neural Arc
Disruption of normal Disruption of normal neuronal control of neuronal control of tearingtearing
Pathophysiology of Chronic Dry Eye Disease
Lacrimal Damage
Stern et al. Cornea. 1998.Nelson et al. Adv Ther. 2000.
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Healthy Tears
Complex Mixture Antimicrobial proteins Growth factors Cytokines
suppress inflammation Mucin secreted by goblet cells
Viscosity Electrolytes
Osmolarity
Image adapted from: Dry Eye and Ocular Surface Disorders. 2004.
Stern et al. In: Dry Eye and Ocular Surface Disorders. 2004.
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Functions of aHealthy Tear Film
Optical clarity, refractive power Ocular surface comfort, lubrication Protection from environmental and infectious
insults Antibacterial proteins, antibodies, complement Reflex tears flush away particles
Trophic environment for corneal epithelium Necessary electrolytes maintain pH Protein factors for growth and wound healing Antioxidants
Rolando et al. Dry Eye and Ocular Surface Disorders. 2004.Stern et al. In: Dry Eye and Ocular Surface Disorders. 2004.
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Tears in Chronic Dry Eye
Decreased proteins and growth factors
Altered cytokine balance promotes inflammation
Proteases activated Increased electrolytes Altered viscositySolomon et al. Invest Ophthalmol Vis Sci. 2001.
Zhao et al. Cornea. 2001.Ogasawara et al. Graefes Arch Clin Exp Ophthalmol. 1996.
Image adapted from: Dry Eye and Ocular Surface Disorders. 2004.
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Effects of Altered Tear Composition in Chronic Dry Eye
Ocular surface tissue environment altered Lubrication compromised due to poor
viscosity Increased osmolarity Imbalanced growth factors and cytokines
fail to promote normal epithelial growth Ocular surface damage
Loss of corneal epithelial integrity Squamous metaplasia of conjunctival
epithelium
Pflugfelder. Am J Ophthalmol. 2004.
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The Look of Dry
Normal Abnormal
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Tear Breakup Time (TBUT)
Tear film instability is a hallmark of dry eye
Correlates with aqueous and evaporative tear deficiency (Pflugfelder et al, 1998)
TBUT measures tear film quality Fluorescein introduced from strip, yellow filter increases
sensitivity TBUT = time from completed blink to 1st dry spot (3
repetitions)
TBUT < 10 seconds abnormal (Lemp, 1995)
Anesthesia decreases TBUT (de Paiva et al, 2004)
Abnormal corneal surface - > break-up spots
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Lissamine Green Stainingin Dry Eye
Lissamine green detects dead or degenerated conjunctival cells
Exposure zone staining with limbal sparing
Exposure zone staining with limbal staining
Intense diffuse staining of exposure zone, limbal staining
Images from Dry Eye and Ocular Surface Disorders. 2004.
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Vital StainsFluorescein Rose Bengal Lissamine
Green
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Schirmer’s Strips
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“Dry Eyes” are Very Common 25% of office visits in a general
practice 4 in 10 Americans suffer from dry
eye symptoms (Gallup Poll 2004) Affects 20 million Americans
(Market Scope 2004) Prevalence: 14% of adults 48 – 91
years old
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Dry Eye Patient Factors Older age Female gender Post-menopausal Tobacco smoking Contact lens wear Prolonged staring (e.g. computer
work)
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Environmental Factors Air Pollution Artificial, forced air Allergens Low humidity
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Medications Antihistamines Antidepressants Antispasmodics Diruetics Oral contraceptives Hormonal therapy
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Disease Related Factors Systemic:
Autoimmune disease Neurologic disease that reduces blink Vitamin A deficiency
Local: Lacrimal gland infiltration Eyelid malposition or laxity Ocular surface disease
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Dry Eye Management Mild to Moderate
Symptoms
Minimal signs Consider environment/intake Add tear replacement
Osmolarity Viscosity Combination
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Dry Eye ManagementModerate to Severe
Symptoms Abnormal tear film, corneal and
conjunctival staining visual signs Essential fatty acids (EFA)
Flaxseed oil, Hydroeye® Topical anti-inflammatory agents
Cyclosporine Oral cholinergics
Pilocarpine (Salagen®) Cevimeline
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26Behrens et al. Cornea. 2006.
Consensus Treatment Algorithm Guidelines
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Dry Eye Management Mild to Moderate Symptoms
Minimal or no signs Add Essential fatty acids (EFA)
Flaxseed oil, Hydroeye® Add tear replacement
Osmolarity Viscosity Combination
Restasis
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Dry Eye ManagementModerate to Severe Symptoms
Signs present: Abnormal tear film, corneal and conjunctival staining
Essential fatty acids (EFA) Flaxseed oil, Hydroeye®
Topical anti-inflammatory agents Cyclosporine
If dry mouth also present: consider oral cholinergics Pilocarpine (Salagen®) Cevimeline
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RestasisDosing and Administration
Not “as needed” like traditional eye drops One drop-each eye in morning & evening Vials should be discarded after each use Two vials per day are required, and that’s
why it’s important for patients to receive 2 trays for 30 days
Artificial tears may be used for concomitant relief (no preservatives much better !)
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RESTASIS® increases tear production
in some patients
In pivotal trials, the use of RESTASIS® twice a day for 6 months (2000) Increased goblet cell density Increased tear production Decreased corneal staining Reduced reliance on artificial tears
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Dry EyeSurgical Management
Punctal occlusion Plugs Cautery
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Thank You!Thank You!Thank You!Thank You!
Kimberly Cockerham, MD, Kimberly Cockerham, MD, FACSFACSwww.CalEyes.comLos Altos –Come Visit !!! Los Altos –Come Visit !!!
Kimberly Cockerham, MD, Kimberly Cockerham, MD, FACSFACSwww.CalEyes.comLos Altos –Come Visit !!! Los Altos –Come Visit !!!