TAG Mail 2014 (January - June)

Cumulative Listing of Reports, Publications, Medication Safety Information and Papers of Interest

TAG Mail 25th June 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**AIHW- Australia's Health 2014http://www.aihw.gov.au/publication-detail/?id=60129547205- Acute coronary syndrome: validation of the method used to monitor incidence in Australiahttp://www.aihw.gov.au/publication-detail/?id=60129547563

**TGAAusPARs added: Brentuximab vedotin, Turoctocog alfa (rch), Denosumab, Dolutegravir (as sodium), Fentanyl (as citrate), Golimumab (rmc), Olodaterol (as hydrochloride)http://www.tga.gov.au/industry/pm-auspar.htm

REPORTS AND PUBLICATIONS – INTERNATIONAL**Dept of Health (UK)- UK 5 Year Antimicrobial Resistance (AMR) Strategy 2013-2018 - Measuring successhttps://www.gov.uk/government/uploads/system/uploads/attachment_data/file/322358/Outcome_measures.pdf- A new webpage is now available bringing together information on publications, tools and resources and news items relevant to antimicrobial stewardship.https://www.gov.uk/government/collections/antimicrobial-resistance-amr-information-and-resources

**EMAPosting of clinical trial summary results in European Clinical Trials Database (EudraCT) to become mandatory for sponsors http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2014/06/news_detail_002127.jsp&mid=WC0b01ac058004d5c1

**FDA- FDA approves Sivextro (tedizolid phosphate), a new antibacterial drug, to treat adults with skin infections.http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm402174.htm- FDA actions reduce drug shortages but critical issues remainhttp://www.fda.gov/Drugs/NewsEvents/ucm401553.htm

**NICE- Clinical Guideline CG180, Atrial fibrillation (update): the management of atrial fibrillationhttp://guidance.nice.org.uk/CG180- Evidence Update 62, Antibiotics for early-onset neonatal infection. A summary of selected new evidence relevant to NICE clinical guideline 149 ‘Antibiotics for early-onset neonatal infection: antibiotics for the prevention and treatment of early-onset neonatal infection’ (2012)https://www.evidence.nhs.uk/evidence-update-62- Evidence summary, new medicine: Psoriatic arthritis in adults: certolizumab pegolhttp://www.nice.org.uk/mpc/evidencesummariesnewmedicines/ESNM42.jsp

MEDICATION SAFETY**TGAMonitoring communication: Ivabradine (Coralan) and cardiovascular events in patients with anginahttp://www.tga.gov.au/safety/ews-medicine-ivabradine-140623.htm

**FDA- FDA Drug Safety Communications: -- FDA review of cardiovascular risks for diabetics taking hypertension drug olmesartan not conclusive; label updates requiredhttp://www.fda.gov/Drugs/DrugSafety/ucm402323.htm-- FDA warns that cancer drug docetaxel may cause symptoms of alcohol intoxication after treatmenthttp://www.fda.gov/Drugs/DrugSafety/ucm401752.htm- Consumer Information: Four Medication Safety Tips for Older Adultshttp://www.fda.gov/downloads/ForConsumers/ConsumerUpdates/UCM399867.pdf

**ISMPSome IV medications are diluted unnecessarily in patient care areas, creating undue riskhttp://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=82

**Joint CommissionSentinel Event Alert Issue 52: Preventing infection from the misuse of vialshttp://www.jointcommission.org/assets/1/6/SEA_52.pdf

**MHRA

Drug Safety Update, June 2014. Includes:- Combination use of medicines from different classes of renin-angiotensin system blocking agents: risk of hyperkalaemia, hypotension, and impaired renal function—new warnings - Ferumoxytol: serious hypersensitivity reactions—reminder of precautions to take before and during administration - Ivabradine: emerging clinical trial evidence of increased cardiovascular risk—carefully monitor for bradycardia - Chlorhexidine solutions: risk of chemical burn injury to skin in premature infants http://www.mhra.gov.uk/home/groups/dsu/documents/publication/con428334.pdf

PAPERS OF INTEREST**Am J CardiolMeta-Analysis of Randomized Clinical Trials Comparing Short-Term Versus Long-Term Dual Antiplatelet Therapy Following Drug-Eluting Stentshttp://www.sciencedirect.com/science/article/pii/S0002914914010492

**BMJ- Drug treatment for attention-deficit/hyperactivity disorder and suicidal behaviour: register based studyhttp://www.bmj.com/content/348/bmj.g3769- Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: quasi-experimental studyhttp://www.bmj.com/content/348/bmj.g3596- Revascularisation versus medical treatment in patients with stable coronary artery disease: network meta-analysishttp://www.bmj.com/content/348/bmj.g3859- Prescription charges: are they worth it?http://www.bmj.com/content/348/bmj.g3944- Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United Stateshttp://www.bmj.com/content/348/bmj.g3656

**Circ Cardiovasc IntervHeparin Monotherapy or Bivalirudin During Percutaneous Coronary Intervention in Patients With Non–ST-Segment–Elevation Acute Coronary Syndromes or Stable Ischemic Heart Disease: Results From the Evaluation of Drug-Eluting Stents and Ischemic Events Registryhttp://circinterventions.ahajournals.org/content/7/3/365.abstract?etoc

**HeartAtrial fibrillation associated with ivabradine treatment: meta-analysis of randomised controlled trialshttp://heart.bmj.com/content/early/2014/06/20/heartjnl-2014-305482.abstract

**J Adv Nurs

Paediatric nurses' adherence to the double-checking process during medication administration in a children's hospital: an observational studyhttp://onlinelibrary.wiley.com/doi/10.1111/jan.12303/abstract

**LancetRituximab for childhood-onset, complicated, frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a multicentre, double-blind, randomised, placebo-controlled trialhttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60541-9/abstract

**NEJM- Antidepressant Use in Pregnancy and the Risk of Cardiac Defectshttp://www.nejm.org/doi/full/10.1056/NEJMoa1312828- Tofacitinib versus Methotrexate in Rheumatoid Arthritishttp://www.nejm.org/doi/full/10.1056/NEJMoa1310476

**JAMIAHow is the electronic health record being used? Use of EHR data to assess physician-level variability in technology usehttp://jamia.bmj.com/content/early/2014/06/09/amiajnl-2013-002627.short?g=w_jamia_ahead_tab

TAG Mail 18th June 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**NSW HealthStandards for Paediatric Intravenous Fluidshttp://www0.health.nsw.gov.au/policies/gl/2014/GL2014_009.html

**NPSNPS Direct, June 2014. Includes:Is acupuncture effective for pain relief? e-Cigarettes: a safe way to quit? Childhood antibiotics and links to asthma; Fast five – Good advice about common vices; Enhanced monitoring for meningococcal B vaccine; EMA investigating safety of ivabradine for coronary artery diseasehttp://www.nps.org.au/publications/health-professional/nps-direct/2014/june

**TGA- Required Advisory Statements for Medicine Labels (RASML) and the Labelling Order (TGO 69, effective 12 June 2014): Information for consumers, health professionals and industry http://www.tga.gov.au/newsroom/media-2014-rasml-tgo69-140613.htm- BioCSL Fluvax - investigations into the cause of fevers in children under 5 yearshttp://www.tga.gov.au/safety/alerts-medicine-biocsl-fluvax-140612.htm- AusPARs added: catridecacog (rys), etanercept (rch) and nonacog gamma

http://www.tga.gov.au/industry/pm-auspar.htm

**AIHW- The measurement of patient experience in non-GP primary health care settingshttp://www.aihw.gov.au/publication-detail/?id=60129547332- Assessment of Global Burden of Disease 2010 methods for the Australian context: Australian Burden of Disease Study Working paper No. 1http://www.aihw.gov.au/WorkArea/DownloadAsset.aspx?id=60129547710- National Opioid Pharmacotherapy Statistics 2013http://www.aihw.gov.au/publication-detail/?id=60129547308

REPORTS AND PUBLICATIONS – INTERNATIONAL**BTSA UK based resource to support the monitoring and safe use of anti-tuberculosis drugs and second line treatment of multidrug-resistant tuberculosishttp://www.tbdrugmonographs.co.uk/uploads/2/8/9/4/28941471/mdrtb_adr_monitoring_guidancefinal.pdf

**NICEEyes on Evidence, June 2014. Includes:Acid-suppressive drugs and oesophageal adenocarcinoma in Barrett's oesophagus; Prescriptions for anxiolytics and hypnotics and risk of death; Assessment and treatment of dementia in older adultshttps://www.evidence.nhs.uk/eyes-on-evidence-june-2014.pdf

**PHE'Don’t just screen, intervene': improved guidance from Public Health England to improve the health of people living with a mental illness - the updated Lester Tool https://www.gov.uk/government/news/dont-just-screen-intervene-improved-guidance-to-improve-the-health-of-people-living-with-a-mental-illness

MEDICATION SAFETY**Dept of health (UK)Estates and Facilities Alert: E-cigarettes, batteries and chargers, potential for fire or explosionhttps://www.cas.dh.gov.uk/ViewandAcknowledgment/ViewAlert.aspx?AlertID=102177

**FDAPotential Signals of Serious Risks/New Safety Information Identified by the FDA Adverse Event Reporting System (FAERS) between January – March 2014. Includes: Brentuximab vedotin (Adcetris); Testosterone products; Antidepressant products (except monoamine oxidase inhibitors (MAOIs))http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Surveillance/AdverseDrugEffects/ucm398223.htm

**Health CanadaZofran (ondansetron) - Dosage and Administration of Intravenous Ondansetron in Geriatrics (>65 years of age)http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/39943a-eng.php

**ISMP Canada Safety Bulletin, June 2014. Includes:Safety checklist: a new approach to promote safe prescribing of and counselling for DIANE-35 and its generics; Reported confusion with insulin syringe labelling; Preventing harm from drug-food interactionshttp://www.ismp-canada.org/download/safetyBulletins/2014/ISMPCSB2014-6_SafetyChecklist_DIANE-35.pdf#page=1

**Joint CommissionSpeak Up: Anesthesia and Sedation - Infographic available to downloadhttp://www.jointcommission.org/speakup_anesthesia_sedation/

PAPERS OF INTEREST**Am J Health Syst PharmImpact of an antimicrobial stewardship program on patients with acute bacterial skin and skin structure infectionshttp://www.ajhp.org/content/71/13/1136.abstract?etoc

**BMJ Quality and Safety- Interventions employed to improve intrahospital handover: a systematic reviewhttp://qualitysafety.bmj.com/content/23/7/600 - Collaborative pharmaceutical care in an Irish hospital: uncontrolled before-after studyhttp://qualitysafety.bmj.com/content/23/7/574.full - We need to talk: an observational study of the impact of electronic medical record implementation on hospital communicationhttp://qualitysafety.bmj.com/content/23/7/584.abstract

**Cochrane- Sumatriptan (all routes of administration) for acute migraine attacks in adults - overview of Cochrane reviewshttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009108.pub2/full - Pericyazine for schizophreniahttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007479.pub2/full - Antibiotic therapy versus no antibiotic therapy for children aged two to 59 months with WHO-defined non-severe pneumonia and wheezehttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009576.pub2/full - Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertensionhttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003824.pub2/full - Antibiotic therapy versus no antibiotic therapy for children aged two to 59 months with WHO-defined non-severe pneumonia and wheeze

http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009576.pub2/full - Vitamin K for improved anticoagulation control in patients receiving warfarinhttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009917.pub2/full

**Diabetes CareType 1 diabetes through the life span: A Position Statement of the American Diabetes Associationhttp://care.diabetesjournals.org/content/early/2014/06/09/dc14-1140.full.pdf%20html

**Eur Heart J- Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysishttp://eurheartj.oxfordjournals.org/content/early/2014/06/10/eurheartj.ehu218.abstract- Effect of B-type natriuretic peptide-guided treatment of chronic heart failure on total mortality and hospitalization: an individual patient meta-analysishttp://eurheartj.oxfordjournals.org/content/35/23/1559.abstract

**Injury PreventionInvestigating the long-term consequences of adverse medical events among older adultshttp://injuryprevention.bmj.com/content/early/2014/04/21/injuryprev-2013-041043

**Int J Clin PharmLook alike/sound alike drugs: a literature review on causes and solutionshttp://link.springer.com/article/10.1007%2Fs11096-013-9885-6

**J Am Coll SurgReducing Postoperative Venous Thromboembolism Complications with a Standardized Risk-Stratified Prophylaxis Protocol and Mobilization Programhttp://www.journalacs.org/article/S1072-7515(14)00186-0/abstract

**JAMA- Association Between Tumor Necrosis Factor-α Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Diseasehttp://jama.jamanetwork.com/article.aspx?articleid=1881309- Thrombolysis for Pulmonary Embolism and Risk of All-Cause Mortality, Major Bleeding, and Intracranial Hemorrhage: A Meta-analysishttp://jama.jamanetwork.com/article.aspx?articleid=1881311

**JAMA Intern Med- Genotype-Guided vs Clinical Dosing of Warfarin and Its Analogues: Meta-analysis of Randomized Clinical Trialshttp://archinte.jamanetwork.com/article.aspx?articleid=1881013

- Preoperative β-Blocker Use in Coronary Artery Bypass Grafting Surgery: National Database Analysishttp://archinte.jamanetwork.com/article.aspx?articleid=1881012- Benefits and Risks of Anticoagulation Resumption Following Traumatic Brain Injuryhttp://archinte.jamanetwork.com/article.aspx?articleid=1878303- Antibiotic Overuse and Clostridium difficile: A Teachable Momenthttp://archinte.jamanetwork.com/article.aspx?articleid=1881016

**JAMA PediatricsBreastfeeding in Children of Women Taking Antiepileptic Drugs: Cognitive Outcomes at Age 6 Yearshttp://archpedi.jamanetwork.com/article.aspx?articleid=1881246

**LancetLong-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trialhttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60683-8/abstract

**MJA- Letter to the editor: Off label prescribing (M Gazarian, S Morris)https://www.mja.com.au/journal/2014/200/11/label-prescribing- A framework for overcoming disparities in management of acute coronary syndromes in the Australian Aboriginal and Torres Strait Islander populationA consensus statement from the National Heart Foundation of Australiahttps://www.mja.com.au/journal/2014/200/11/framework-overcoming-disparities-management-acute-coronary-syndromes-australian

**PediatricsAdverse Drug Event-Related Emergency Department Visits Associated With Complex Chronic Conditionshttp://pediatrics.aappublications.org/content/133/6/e1575

TAG Mail 11th June 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**AIHW- Projections of the prevalence of treated end-stage kidney disease in Australia: 2012-2020http://www.aihw.gov.au/publication-detail/?id=60129547202- Head and neck cancers in Australiahttp://www.aihw.gov.au/publication-detail/?id=60129547291

**TGABehind the news: Liquid nicotine and personal importation for use in electronic cigaretteshttp://www.tga.gov.au/newsroom/btn-liquid-nicotine.htm

REPORTS AND PUBLICATIONS – INTERNATIONAL**ABPIABPI position on biosimilar medicineshttp://www.abpi.org.uk/_layouts/download.aspx?sourceurl=/our-work/library/Documents/ABPI%20position%20on%20biosimilar%20medicines.pdf

**BNF BNF Update, June 2014- Changes in the legal classification of Tramadol, Lisdexamfetamine, Zaleplon, and Zopiclone- Dosing schedule for haloperidolhttp://www.pharmpress.com/mailouts/bnf/jun14/BNF_enewsletter.html

**IHI- Safety First Blog: Reducing C. diff, Everyone Has a Part to Playhttp://www.ihi.org/communities/blogs/_layouts/ihi/community/blog/itemview.aspx?List=0f316db6-7f8a-430f-a63a-ed7602d1366a&ID=30- New video added to the series The Science of Improvement on a Whiteboard: Static vs. Dynamic Displays of Datahttp://www.ihi.org/education/IHIOpenSchool/resources/Pages/BobLloydWhiteboard.aspx

**NICEEvidence Summary: New Medicine- ESNM41: Long-acting reversible contraception: levonorgestrel 13.5 mg intrauterine delivery systemhttp://www.nice.org.uk/mpc/evidencesummariesnewmedicines/ESNM41.jsp

**NHS EnglandPatient Safety Alert Stage Three: Directive - Standardising the early identification of Acute Kidney Injuryhttp://www.england.nhs.uk/2014/06/09/psa-aki/

**SIGNClinical Guideline: Management of primary cutaneous squamous cell carcinomahttp://www.sign.ac.uk/pdf/SIGN140.pdf

MEDICATION SAFETY**CDCCalls to Poison Centers for Exposures to Electronic Cigarettes — United States, September 2010–February 2014http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6313a4.htm

**HQSC NZMedication Safety Watch, June 2014. Includes:- Safe medicine administration through enteral feeding tubes- Metoprolol alert- England's medication error incident reporting and learning alert- Intravenous administration of oral medicines http://www.hqsc.govt.nz/our-programmes/medication-safety/publications-and-resources/publication/1570/

**ISMPMisidentification of alphanumeric symbolshttp://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=81

**MHRAAdrenaline Auto-injectors: A Review of Clinical and Quality Considerationshttp://www.mhra.gov.uk/home/groups/comms-ic/documents/websiteresources/con423091.pdf

**TGA- Accu-Chek Spirit Combo insulin pump - serial numbers 10171897 to 10281629: Recall - potential for delay to treatment in rare cases http://www.tga.gov.au/safety/alerts-device-accu-chek-insulin-pump-140606.htm- Accu-Chek Mobile blood glucose meter: Recall for product correction - potential for incorrect readings http://www.tga.gov.au/safety/alerts-device-accu-chek-glucose-meter-140606.htm

PAPERS OF INTEREST**Ann Intern MedRate- and Rhythm-Control Therapies in Patients With Atrial Fibrillation: A Systematic Reviewhttp://annals.org/article.aspx?articleid=1877019

**BMJ- Benefits and harms in clinical trials of duloxetine for treatment of major depressive disorder: comparison of clinical study reports, trial registries, and publicationshttp://www.bmj.com/content/348/bmj.g3510- Coding of adverse events of suicidality in clinical study reports of duloxetine for the treatment of major depressive disorder: descriptive studyhttp://www.bmj.com/%5Bfield_highwire_a_cpath-raw%5D-5

**BMJ Qual SafMitigating errors caused by interruptions during medication verification and administration: interventions in a simulated ambulatory chemotherapy setting

http://qualitysafety.bmj.com/content/early/2014/06/06/bmjqs-2013-002484.abstract

**Cochrane- Adjuvant chemotherapy for advanced endometrial cancer http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010681.pub2/full- Aminoadamantanes for chronic hepatitis C http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010125.pub2/full- Antibiotic therapy versus no antibiotic therapy for children aged two to 59 months with WHO-defined non-severe pneumonia and wheeze http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009576.pub2/full- Antibody induction versus corticosteroid induction for liver transplant recipients http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010252.pub2/full- HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysishttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007784.pub2/abstract

**Eur J Hosp Pharm- The impact of UK Medicines Information services on patient care, clinical outcomes and medicines safety: an evaluation of healthcare professionals’ opinions http://ejhp.bmj.com/content/early/2014/06/09/ejhpharm-2014-000462?papetoc- Persistence with oral antiviral therapy in previously untreated patients with chronic hepatitis B in Spain: the EUPTHEA studyhttp://ejhp.bmj.com/content/early/2014/06/06/ejhpharm-2014-000452?papetoc- Economic impact of antifungal treatment in IFD by Candida species: anidulafungin administration as a cost-effective alternative for critical care patientshttp://ejhp.bmj.com/content/early/2014/06/05/ejhpharm-2013-000408?papetoc

**JAMA- Association Between Intensification of Metformin Treatment With Insulin vs Sulfonylureas and Cardiovascular Events and All-Cause Mortality Among Patients With Diabeteshttp://jama.jamanetwork.com/article.aspx?articleid=1878717 - Recurrence and Mortality Following Severe Cutaneous Adverse Reactionshttp://jama.jamanetwork.com/article.aspx?articleid=1877196- Association of Azithromycin With Mortality and Cardiovascular Events Among Older Patients Hospitalized With Pneumoniahttp://jama.jamanetwork.com/article.aspx?articleid=1877208- Clinical Evidence Synopsis: Prophylactic Antibiotic Therapy in Chronic Obstructive Pulmonary Diseasehttp://jama.jamanetwork.com/article.aspx?articleid=1877188

**JAMA PsychEfficacy of Pharmacotherapy and Psychotherapy for Adult Psychiatric Disorders: A Systematic Overview of Meta-analyseshttp://archpsyc.jamanetwork.com/article.aspx?articleid=1865002

**J Intern MedStatin use reduces the risk of dementia in elderly patients: a nationwide data survey and propensity analysishttp://onlinelibrary.wiley.com/doi/10.1111/joim.12262/abstract;jsessionid=9B7FD7C7069D059BBDA1003976C1E96C.f03t01

**Lancet PsychMonitoring white blood cell count in adult patients with schizophrenia who are taking clozapine: a cost-effectiveness analysishttp://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(14)70245-7/abstract

**Lancet Inf DisTedizolid for 6 days versus linezolid for 10 days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomised, double-blind, phase 3, non-inferiority trialhttp://www.thelancet.com/journals/laninf/article/PIIS1473-3099(14)70737-6/abstract

**NEJM- Naloxegol for Opioid-Induced Constipation in Patients with Noncancer Painhttp://www.nejm.org/doi/full/10.1056/NEJMoa1310246- Once-Weekly Dalbavancin versus Daily Conventional Therapy for Skin Infectionhttp://www.nejm.org/doi/full/10.1056/NEJMoa1310480- Single-Dose Oritavancin in the Treatment of Acute Bacterial Skin Infectionshttp://www.nejm.org/doi/full/10.1056/NEJMoa1310422

TAG Mail 3rd June 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**TGA- Provive and Sandoz propofol 1% emulsion for injection - all sizes and all batches: Safety advisory - potential bacterial contamination. Updates made to the statement published on 9 May 2014 to include details about ongoing investigations into this issue, including results of TGA testing of affected batches, and details of confirmed cases of contamination with Ralstonia bacteria.

http://www.tga.gov.au/safety/alerts-medicine-provive-mct-lct-140530.htm- AusPARs: added Loteprednol etabonate, Misoprostol, Palonosetron hydrochloride, Pasireotide (as diaspartate), Afatinib (as dimaleate), Bevacizumab injection, Insulin detemir (rys)http://www.tga.gov.au/industry/pm-auspar.htm

REPORTS AND PUBLICATIONS – INTERNATIONAL**AHRQWeb M&M Spotlight Case Studies (with commentary):- Medication Reconciliation With a Twist (or Dare We Say, a Patch?)http://webmm.ahrq.gov/case.aspx?caseID=323- Discontinued Medications: Are They Really Discontinued?http://webmm.ahrq.gov/case.aspx?caseID=325

**CADTHRapid Response Reports:- Fentanyl Transdermal Patches in Palliative Care: Clinical Effectiveness, Safety, and Guidelineshttp://www.cadth.ca/media/pdf/htis/jun-2014/RB0685%20Fentanyl%20Transdermal%20Patch%20Final.pdf- Bivalirudin Infusion Following Angioplasty: Safetyhttp://www.cadth.ca/media/pdf/htis/may-2014/RB0689%20Bivalirudin%20Infusions%20Final.pdf

**FDADraft Guidance for Industry: Best Practices in Developing Proprietary Names for Drugshttp://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM398997.pdf

**NHS EvidenceEvidence Update May 2014. Sickle cell acute painful episode: A summary of selected new evidence relevant to NICE clinical guideline 143 ‘Sickle cell acute painful episode: management of an acute painful sickle cell episode in hospital’ https://www.evidence.nhs.uk/evidence-update-60012

**NICETechnology Appraisals- TA313: Psoriatic arthritis (active) - ustekinumab http://guidance.nice.org.uk/TA313- TA312: Multiple sclerosis (relapsing-remitting) - alemtuzumab http://guidance.nice.org.uk/TA312

MEDICATION SAFETY**TGAMedicines Safety Update, June 2014. In this issue:- Bexsero meningococcal B vaccine - enhanced monitoring- Strontium ranelate and cardiovascular and venous thromboembolic risks- Complex regional pain syndrome and vaccines

- Azathioprine and cytomegalovirus reactivationhttp://www.tga.gov.au/hp/msu-2014-06.htm

**MHRADrug Safety Update, May 2014. Includes:- Domperidone: risks of cardiac side effects- Voriconazole: reminder of risk of liver toxicity, phototoxicity, and squamous cell carcinoma- Adrenaline auto-injector advice for patients- Statins benefits and risks- Zolpidem: risk of drowsiness and reduced driving abilityhttp://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/index.htm

PAPERS OF INTEREST**BMJ- Higher potency statins and the risk of new diabetes: multicentre, observational study of administrative databaseshttp://www.bmj.com/content/348/bmj.g3244- Effect of fixed dose combination treatment on adherence and risk factor control among patients at high risk of cardiovascular disease: randomised controlled trial in primary carehttp://www.bmj.com/content/348/bmj.g3318- Time to treatment with recombinant tissue plasminogen activator and outcome of stroke in clinical practice: retrospective analysis of hospital quality assurance data with comparison with results from randomised clinical trialshttp://www.bmj.com/content/348/bmj.g3429

**Eur J Clin PharmacolIdentifying high-risk medication: a systematic literature reviewhttp://rd.springer.com/article/10.1007/s00228-014-1668-z

**Int J Qual HealthcareEffects of patient-, environment- and medication-related factors on high-alert medication incidentshttp://intqhc.oxfordjournals.org/content/26/3/308

**JAMA Intern Med5α-Reductase Inhibitors and Risk of High-Grade or Lethal Prostate Cancerhttp://archinte.jamanetwork.com/article.aspx?articleid=1878668

**J Am Heart Assoc- Delay in Filling First Clopidogrel Prescription After Coronary Stenting Is Associated With an Increased Risk of Death and Myocardial Infarctionhttp://jaha.ahajournals.org/content/3/3/e000669.abstract.html?cpetoc- The incidence of kidney injury for patients treated with a high-potency versus moderate-potency statin regimen after an acute coronary syndromehttp://jaha.ahajournals.org/content/3/3/e000784.long

**J Clin Onc- Adjuvant Endocrine Therapy for Women With Hormone Receptor–Positive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline Focused Updatehttp://jco.ascopubs.org/content/early/2014/05/20/JCO.2013.54.2258.abstract- Series: Pain in patients with cancerhttp://jco.ascopubs.org/content/current

**Lancet- Global, regional, and national prevalence of overweight and obesity in children and adults during 1980—2013: a systematic analysis for the Global Burden of Disease Study 2013http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60460-8/abstract- Efficacy and safety of nebivolol and valsartan as fixed-dose combination in hypertension: a randomised, multicentre studyhttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60614-0/abstract- Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million peoplehttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60685-1/abstract- Hypertension management in England: a serial cross-sectional study from 1994 to 2011http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60688-7/abstract

**Lancet Resp MedAzithromycin maintenance treatment in patients with frequent exacerbations of chronic obstructive pulmonary disease (COLUMBUS): a randomised, double-blind, placebo-controlled trial.http://www.sciencedirect.com/science/article/pii/S2213260014700190

**RheumatolSafety of resuming tumour necrosis factor inhibitors in patients who developed tuberculosis as a complication of previous TNF inhibitors.http://rheumatology.oxfordjournals.org/content/early/2014/03/27/rheumatology.keu041.long

**StrokeVitamin K Antagonists and Risk of Subdural Hematoma: Meta-Analysis of Randomized Clinical Trialshttp://stroke.ahajournals.org/content/early/2014/05/13/STROKEAHA.114.005430

28th May 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**ACSQHCExploring Healthcare Variation in Australia: Analyses Resulting from an OECD Study http://www.safetyandquality.gov.au/publications/exploring-healthcare-variation-in-australia/

**AIHWArthritis and other musculoskeletal conditions across the life stageshttp://www.aihw.gov.au/publication-detail/?id=60129547059

**TGAMedicine Shortages Information Initiativehttp://www.tga.gov.au/hp/information-msi.htm

REPORTS AND PUBLICATIONS - INTERNATIONAL**AHRQCarbapenem-Resistant Enterobacteriaceae (CRE) Control and Prevention Toolkithttp://www.ahrq.gov/cretoolkit

**FDA- FDA approves Dalvance (dalbavancin), a new antibacterial drug used to treat adults with skin infectionshttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm398724.htm- FDA approves Entyvio (vedolizumab) injection to treat adult patients with moderate to severe ulcerative colitis and adult patients with moderate to severe Crohn‘s diseasehttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm398065.htm

**NHS EvidenceEvidence Update May 2014. Opioids in palliative care: A summary of selected new evidence relevant to NICE clinical guideline 140 ‘Opioids in palliative care: safe and effective prescribing of strong opioids for pain in palliative care of adults’ (2012)http://www.evidence.nhs.uk/evidence-update-58

**NIHTWhat is the clinical effectiveness and cost-effectiveness of cytisine compared with varenicline for smoking cessation? A systematic review and economic evaluationhttp://www.journalslibrary.nihr.ac.uk/hta/volume-18/issue-33

MEDICATION SAFETY

**Health CanadaVectibix (panitumumab) - Rare Cases of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/39581a-eng.php

**ISMPAdministering just the diluent or one of two vaccine components leaves patients unprotectedhttp://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=80

PAPERS OF INTEREST**Am J Health Syst PharmEvaluation of dedicated infectious diseases pharmacists on antimicrobial stewardship teamshttp://www.ajhp.org/content/71/12/1019.abstract?etoc

**BMJHelicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomised controlled trialshttp://www.bmj.com/content/348/bmj.g3174

**BMJ Qual SafGovernance of quality of care: a qualitative study of health service boards in Victoria, Australiahttp://qualitysafety.bmj.com/content/23/6/474.abstract

**Diabetes Care- Risk of Lactic Acidosis or Elevated Lactate Concentrations in Metformin Users With Renal Impairment: A Population-Based Cohort Studyhttp://care.diabetesjournals.org/content/early/2014/05/14/dc13-3023.abstract- Efficacy and Safety of Dulaglutide Monotherapy Versus Metformin in Type 2 Diabetes in a Randomized Controlled Trial (AWARD-3)http://care.diabetesjournals.org/content/early/2014/05/14/dc13-2759.abstract

**Eur Heart JIntravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)http://eurheartj.oxfordjournals.org/content/35/19/1255.abstract.html?etoc

**JAMA- Durability of Class I American College of Cardiology/American Heart Association Clinical Practice Guideline Recommendationshttp://jama.jamanetwork.com/article.aspx?articleid=1874510

- Effect of a Perioperative, Cardiac Output–Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review http://jama.jamanetwork.com/article.aspx?articleid=1873985 - Effectiveness of Paliperidone Palmitate vs Haloperidol Decanoate for Maintenance Treatment of Schizophrenia: A Randomized Clinical Trialhttp://jama.jamanetwork.com/article.aspx?articleID=1872816

**JAMA Intern Med- Low-Dose Estradiol and the Serotonin-Norepinephrine Reuptake Inhibitor Venlafaxine for Vasomotor Symptoms: A Randomized Clinical Trialhttp://archinte.jamanetwork.com/article.aspx?articleid=1876676 - A Comparison of Live Counseling With a Web-Based Lifestyle and Medication Intervention to Reduce Coronary Heart Disease Risk: A Randomized Clinical Trialhttp://archinte.jamanetwork.com/article.aspx?articleid=1876677- Fracture Prediction After Discontinuation of 4 to 5 Years of Alendronate Therapy: The FLEX Studyhttp://archinte.jamanetwork.com/article.aspx?articleid=1867177- High-Risk Use by Patients Prescribed Opioids for Pain and Its Role in Overdose Deathshttp://archinte.jamanetwork.com/article.aspx?articleid=1840033- Informed Consent in Randomized Quality Improvement Trials:  A Critical Barrier for Learning Health Systemshttp://archinte.jamanetwork.com/article.aspx?articleid=1835354- Viewpoint: Why Does Antimicrobial Overuse in Hospitalized Patients Persist?http://archinte.jamanetwork.com/article.aspx?articleid=1838720- Approach to Overuse of Herbal and Dietary Supplements: A Teachable Momenthttp://archinte.jamanetwork.com/article.aspx?articleid=1876678- An Adverse Reaction to a Medication Given to Treat an Adverse Reaction: A Teachable Momenthttp://archinte.jamanetwork.com/article.aspx?articleid=1873081

**LancetIsoniazid plus antiretroviral therapy to prevent tuberculosis: a randomised double-blind, placebo-controlled trialhttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60162-8/abstract

**MJATelemedicine — is the cart being put before the horse?https://www.mja.com.au/journal/2014/200/9/telemedicine-cart-being-put-horse

21st May 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**NPSNPS Direct May 2014, includes: - Can oral zinc help prevent and treat the common cold?- Opioid abuse: will tamper-proof oxycodone help?- Saxagliptin and heart failure: what’s the risk?http://www.nps.org.au/health-professionals/health-news-evidence

REPORTS AND PUBLICATIONS - INTERNATIONAL**EMATransatlantic Taskforce on Antimicrobial Resistance: Progress report May 2014http://ec.europa.eu/health/antimicrobial_resistance/docs/tatfar_progressreport_2014_en.pdf

**MHRAThe benefits and risks of statinshttp://www.mhra.gov.uk/NewsCentre/CON416702

**NICEEvidence summary: new medicine- ESNM40: Premature ejaculation - dapoxetinehttp://www.nice.org.uk/mpc/evidencesummariesnewmedicines/ESNM40.jsp

**NHS EvidenceEyes on Evidence May 2014. Includes:- Ibuprofen compared with indometacin for patent ductus arteriosushttps://www.evidence.nhs.uk/eyes-on-evidence-may-2014.pdf

**NHS EnglandVital support for young people with mental health problems: HeadMeds,a unique new website about mental health medication for young people aged 13-25, has been launched.http://www.england.nhs.uk/2014/05/14/geraldine-strathdee-5/ andhttp://www.headmeds.org.uk/

**PHE- Electronic cigarettes: A report commissioned by Public Health Englandhttps://www.gov.uk/government/uploads/system/uploads/attachment_data/file/311887/Ecigarettes_report.pdf- E-cigarette uptake and marketing: A report commissioned by Public Health Englandhttps://www.gov.uk/government/uploads/system/uploads/attachment_data/file/311491/Ecigarette_uptake_and_marketing.pdf

MEDICATION SAFETY**Health CanadaNew safety information: Risk of serotonin syndrome associated with serotonin blocking drugs used to treat nausea and vomitinghttp://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/39519a-eng.php

**ISMP CanadaSafety Bulletin May 2014, includes:Preventable Death Highlights the Need for Improved Management of Known Drug Interactionshttp://www.ismp-canada.org/download/safetyBulletins/2014/ISMPCSB2014-5_KnownDrugInteractions.pdf#page=1

PAPERS OF INTEREST**Am J Health Syst PharmProphylaxis against venous thromboembolism in hospitalized medically ill patients: Update and practical approachhttp://www.ajhp.org/cgi/content/abstract/71/11/909?etoc

**Ann Intern MedBiological Agents for Moderately to Severely Active Ulcerative Colitis: A Systematic Review and Network Meta-analysishttp://annals.org/article.aspx?articleid=1872849

**Australian Health Review-Ten clinician-driven strategies for maximising value of Australian health carehttp://www.publish.csiro.au/?act=view_file&file_id=AH13248.pdf

**BMJLong term maintenance of weight loss with non-surgical interventions in obese adults: systematic review and meta-analyses of randomised controlled trialshttp://www.bmj.com/content/348/bmj.g2646Comparative effectiveness of long term drug treatment strategies to prevent asthma exacerbations: network meta-analysishttp://www.bmj.com/content/348/bmj.g3009

**Circulation- Trends of Hospitalization for Atrial Fibrillation in the United States, 2000 Through 2010: Implications for Healthcare Planninghttp://circ.ahajournals.org/content/early/2014/04/23/CIRCULATIONAHA.114.008201.abstract- Editorial: Atrial Fibrillation Epidemic and Hospitalizations: How to Turn the Rising Tide?http://circ.ahajournals.org/content/early/2014/04/23/CIRCULATIONAHA.114.010073.abstract- Lack of Concordance Between Empirical Scores and Physician

Assessments of Stroke and Bleeding Risk in Atrial Fibrillation: Results From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registryhttp://circ.ahajournals.org/content/129/20/2005.abstract- Association Between Antipsychotic Use and Risk of Acute Myocardial Infarction: A Nationwide Case-Crossover Studyhttp://circ.ahajournals.org/content/early/2014/05/16/CIRCULATIONAHA.114.008779.abstract

**CochraneInterventions to improve safe and effective medicines use by consumers: an overview of systematic reviewshttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007768.pub3/abstract

**JAMA- Preventing Health Care–Associated Harm in Childrenhttp://jama.jamanetwork.com/article.aspx?articleid=1866118 - Effectiveness of Paliperidone Palmitate vs Haloperidol Decanoate for Maintenance Treatment of Schizophrenia: A randomized clinical trialhttp://jama.jamanetwork.com/article.aspx?articleid=1872816

**JAMA Intern Med- National Estimates of Insulin-Related Hypoglycemia and Errors Leading to Emergency Department Visits and Hospitalizationshttp://archinte.jamanetwork.com/article.aspx?articleid=1835360 - Effect of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on All-Cause Mortality, Cardiovascular Deaths, and Cardiovascular Events in Patients With Diabetes Mellitus: A Meta-analysishttp://archinte.jamanetwork.com/issue.aspx

**J Am Geriatr SocNew Oral Anticoagulants in Elderly Adults: Evidence from a Meta-Analysis of Randomized Trialshttp://onlinelibrary.wiley.com/doi/10.1111/jgs.12799/abstract

**J PediatrAdverse Drug Event Detection in Pediatric Oncology and Hematology Patients: Using Medication Triggers to Identify Patient Harm in a Specialized Pediatric Patient Populationhttp://www.sciencedirect.com/science/article/pii/S002234761400287X

**LancetAntivirals for influenza: where now for clinical practice and pandemic preparedness?http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60726-1/fulltext

**MJA

A national study of the processes and outcomes of paediatric formulary applications in Australiahttps://www.mja.com.au/journal/2014/200/9/national-study-processes-and-outcomes-paediatric-formulary-applications-australia

**NEJM- Randomized Trial of Acetylcysteine in Idiopathic Pulmonary Fibrosishttp://www.nejm.org/doi/full/10.1056/NEJMoa1401739- Rosuvastatin for Sepsis-Associated Acute Respiratory Distress Syndrome http://www.nejm.org/doi/full/10.1056/NEJMoa1401520- Simvastatin for the Prevention of Exacerbations in Moderate-to-Severe COPDhttp://www.nejm.org/doi/full/10.1056/NEJMoa1403086

**VaccineVaccines are not associated with autism: An evidence-based meta-analysis of case-control and cohort studieshttp://www.sciencedirect.com/science/article/pii/S0264410X14006367

14th May 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**TGALiquid nicotine and personal importation for use in electronic cigarettes: Public noticehttp://www.tga.gov.au/newsroom/btn-liquid-nicotine.htm

REPORTS AND PUBLICATIONS - INTERNATIONAL**BNFBNF update May 2015. Includes: updated guidance on the treatment of epilepsy; dose of IV metronidazole for neonates and children <2 months; introduction of a Meningococcal group C conjugate vaccine catch-up programme; and restrictions on the use of domperidone.http://www.pharmpress.com/mailouts/bnf/may14/BNF_enewsletter.html

**FDAFDA approves Zontivity (vorapaxar) tablets to reduce the risk of heart attack, stroke, cardiovascular death in high risk patients.http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm396585.htm

**NICEQS62: Constipation in children and young peoplehttp://publications.nice.org.uk/constipation-in-children-and-young-people-qs62

MEDICATION SAFETY**FDA- FDA study of Medicare patients finds risks lower for stroke and death but higher for gastrointestinal bleeding with Pradaxa (dabigatran) compared to warfarinhttp://www.fda.gov/Drugs/DrugSafety/ucm396470.htm- FDA permits manufacturers of oral health care benzocaine products to include a methemoglobinemia warninghttp://www.fda.gov/Drugs/DrugSafety/ucm396985.htm

**HQSCMaking health and disability services safer - Serious Adverse Events report 2012–13http://www.hqsc.govt.nz/our-programmes/reportable-events/publications-and-resources/publication/1190/

**ISMPQuarterWatch: Drug hypersensitivity reactions - Allergic reactions second most frequently reported serious eventhttp://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=79

**TGA- Safety advisory - potential bacterial contamination: Provive and Sandoz propofol 1% emulsion for injection - all sizes and all batches. The statement was updated on 9th May 2014 to include details of the TGA's ongoing investigations into this issue.http://www.tga.gov.au/safety/alerts-medicine-provive-mct-lct-140502.htm- Alere INRatio2 PT/INR heparin-insensitive test strips: Safety alert - potential for incorrect INR results http://www.tga.gov.au/safety/alerts-device-alere-inratio2-140508.htm

**EMA- EU review of hydroxyzine-containing medicines started- EU review of ivabradine (Procoralan) started- Ongoing EU review of safety of ferumoxytol (Rienso)http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2014/05/news_detail_002094.jsp&mid=WC0b01ac058004d5c1

**Health CanadaTemozolomide - Risk of Liver Problems http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/39335a-eng.php

PAPERS OF INTEREST**Ann OncolIs oral chemotherapy prescription safe for patients? A cross-sectional surveyhttp://annonc.oxfordjournals.org/content/25/2/500

**Circ Cardiovasc Qual OutcomesStratifying the Risks of Oral Anticoagulation in Patients With Liver Diseasehttp://circoutcomes.ahajournals.org/content/early/2014/05/13/CIRCOUTCOMES.113.000817.abstract?papetoc

**Circulation- E-Cigarettes: A Scientific Reviewhttp://circ.ahajournals.org/content/129/19/1972.extract- A New START for Sildenafil in Pediatric Pulmonary Hypertension: Reframing the Dose–Survival Relationship in the STARTS-2 Trialhttp://circ.ahajournals.org/content/129/19/1905.extract?etoc

**Lancet Diabetes EndocrinIntensified insulin-based glycaemic control after myocardial infarction: mortality during 20 year follow-up of the randomised Diabetes Mellitus Insulin Glucose Infusion in Acute Myocardial Infarction (DIGAMI 1) trialhttp://www.thelancet.com/journals/landia/article/PIIS2213-8587(14)70088-9/abstract

**Cochrane- Neuraminidase inhibitors for preventing and treating influenza in healthy adults and childrenhttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008965.pub4/abstract;jsessionid=2CDA62817EF17B9A4F8A1F27F2DD3909.f03t04 - Treatment for peritoneal dialysis-associated peritonitishttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD005284.pub3/abstract - Gabapentin for chronic neuropathic pain and fibromyalgia in adultshttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007938.pub3/full- Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-leg immobilizationhttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006681.pub3/full

**Eur Heart J- Expert position paper on the management of antiplatelet therapy in patients undergoing coronary artery bypass graft surgeryhttp://eurheartj.oxfordjournals.org/content/early/2014/05/05/eurheartj.ehu158.full.html?papetoc- Prasugrel plus bivalirudin vs. clopidogrel plus heparin in patients with ST-segment elevation myocardial infarctionhttp://eurheartj.oxfordjournals.org/content/early/2014/05/09/eurheartj.ehu182.abstract.html?papetoc

**JAMA- Effect of Evolocumab or Ezetimibe Added to Moderate- or High-Intensity Statin Therapy on LDL-C Lowering in Patients With Hypercholesterolemia: The LAPLACE-2 Randomized Clinical Trialhttp://jama.jamanetwork.com/article.aspx?articleid=1869210- Pharmacotherapy for Adults With Alcohol Use Disorders in Outpatient

Settings: A Systematic Review and Meta-analysishttp://jama.jamanetwork.com/article.aspx?articleid=1869208- Reducing the Trauma of Hospitalizationhttp://jama.jamanetwork.com/article.aspx?articleid=1867736

**JAMA Intern MedPreventing 30-Day Hospital Readmissions: A Systematic Review and Meta-analysis of Randomized Trialshttp://archinte.jamanetwork.com/article.aspx?articleid=1868538

**J Pat SafetyRoot Cause Analysis of Ambulatory Adverse Drug Events That Present to the Emergency Departmenthttp://journals.lww.com/journalpatientsafety/pages/articleviewer.aspx?year=9000&issue=00000&article=99785&type=abstract

**Lancet- Vitamin D supplementation and falls: a trial sequential meta-analysishttp://www.thelancet.com/journals/landia/article/PIIS2213-8587(14)70068-3/fulltext - Antibiotic use in Eastern Europe: a cross-national database study in coordination with the WHO Regional Office for Europehttp://www.thelancet.com/journals/laninf/article/PIIS1473-3099(14)70071-4/fulltext - Cardiovascular remodelling in coronary artery disease and heart failurehttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60107-0/abstract

**NEJM- Letermovir for Cytomegalovirus Prophylaxis in Hematopoietic-Cell Transplantationhttp://www.nejm.org/doi/full/10.1056/NEJMoa1309533

TAGMail 7th May 2014

REPORTS AND PUBLICATIONS - INTERNATIONAL**CADTH- Rapid response reports:-- Direct Acting Antivirals for Chronic Hepatitis C genotype 1 in Select Populations: Emerging Evidence of Clinical Effectiveness and Safetyhttp://www.cadth.ca/media/pdf/htis/may-2014/RB0673%20DAAs%20for%20select%20populations%20Final.pdf-- Re-treatment with Direct Acting Antivirals for Chronic Hepatitis C Genotype 1: Emerging Evidence of Clinical Effectiveness and Safetyhttp://www.cadth.ca/media/pdf/htis/may-2014/RB0672%20DAA%20treatment%20failure%20Final.pdf

-- Aspirating versus not Aspirating Prior to Injection of Medication: Comparative Clinical Evidence and Guidelineshttp://www.cadth.ca/media/pdf/htis/apr-2014/RB0669%20Aspiration%20Prior%20to%20Injection%20Final.pdf-- Short-Acting Intramuscular Olanzapine for Acute Agitation: Clinical and Cost- Effectiveness and Guidelineshttp://www.cadth.ca/media/pdf/htis/may-2014/RB0671%20IM%20Olanzapine%20Final.pdf-- Apixaban and Rivaroxaban for Stroke Prevention in Atrial Fibrillation: Safetyhttp://www.cadth.ca/media/pdf/htis/apr-2014/RA0668%20Apixaban%20and%20Rivaroxaban%20Final.pdf

**CDERImpact of Abuse-Deterrent Formulations of Opioids – Presentation from the National RxDrug Abuse Summit 2014http://www.fda.gov/downloads/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/UCM395804.pdf?source=govdelivery&utm_medium=email&utm_source=govdelivery

**Dept of Health UKComorbidities: A framework of principles for system-wide actionhttps://www.gov.uk/government/uploads/system/uploads/attachment_data/file/307143/Comorbidities_framework.pdf

**EMANew indication approved for Dabigatran (Pradaxa): treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of recurrent DVT and PE in adults.http://www.ema.europa.eu/docs/en_GB/document_library/Summary_of_opinion/human/000829/WC500165674.pdf

**FDA- Use of Aspirin for Primary Prevention of Heart Attack and Stroke: Information for consumershttp://www.fda.gov/Drugs/ResourcesForYou/Consumers/ucm390574.htm- Consumer resource: Be An Active Member of Your Health Care Teamhttp://www.fda.gov/Drugs/ResourcesForYou/ucm079453.htm- FDA proposes to extend its tobacco authority to additional tobacco products, including e-cigaretteshttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm394667.htm

**RCPWhy asthma still kills: the Royal College of Physicians report of the National Review of Asthma Deaths http://www.rcplondon.ac.uk/projects/national-review-asthma-deaths**SIGN

Care of deteriorating patients: Consensus recommendations http://www.sign.ac.uk/pdf/SIGN139.pdf

**WHOAntimicrobial resistance global report on surveillance: 2014http://apps.who.int/iris/bitstream/10665/112642/1/9789241564748_eng.pdf?ua=1

MEDICATION SAFETY**NSW HealthSafety Alert 002/14: Potential bacterial contamination of propofolhttp://www.health.nsw.gov.au/sabs/Documents/2014-sa-002.pdf

**TGA- Safety advisory - potential bacterial contamination: Provive and Sandoz propofol 1% emulsion for injection - all sizes and all batcheshttp://www.tga.gov.au/safety/alerts-medicine-provive-mct-lct-140502.htm#.U2gm2od_W9I- Medical Devices Safety Update, May 2014. In this issue: Alarm hazards - user error a common contributing factor; Adjustments to syringe plunger forces for new BD 50 ml Plastipak syringeshttp://www.tga.gov.au/hp/mdsu-2014-03.htm

**Health CanadaCanadian Adverse Reaction Newsletter April 2014. Includes:- Quetiapine and acute liver failure- Azithromycin and drug reaction with eosinophilia and systemic symptoms- Clopidogrel and acquired hemophiliahttp://www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/carn-bcei_v24n2-eng.php

PAPERS OF INTEREST**Am J Health Syst PharmCare Transitions Service: A pharmacy-driven program for medication reconciliation through the continuum of carehttp://www.ajhp.org/content/71/10/802.abstract

**Arthritis Rheum- Long-term safety of subcutaneous abatacept in rheumatoid arthritis: Integrated analysis of clinical trial data of up to 4.75 years of treatmenthttp://onlinelibrary.wiley.com/doi/10.1002/art.38687/abstract- Pregnancy Outcome After Methotrexate Treatment for Rheumatic Disease Prior to or During Early Pregnancy: A Prospective Multicenter Cohort Studyhttp://onlinelibrary.wiley.com/doi/10.1002/art.38368/abstract

**Cochrane- Fixed-dose combination therapy for the prevention of cardiovascular diseasehttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009868.pub2/full - Gabapentin for chronic neuropathic pain and fibromyalgia in adults

http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007938.pub3/full - Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-leg immobilizationhttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006681.pub3/full

**Eur Heart JEarly eplerenone treatment in patients with acute ST-elevation myocardial infarction without heart failure: The Randomized Double-Blind Reminder Study http://eurheartj.oxfordjournals.org/content/early/2014/04/23/eurheartj.ehu164.abstract

**Eur J Hosp PharmPharmacy care and adherence to primary and secondary prevention cardiovascular medication: a systematic review of studieshttp://ejhp.bmj.com/content/early/2014/05/02/ejhpharm-2014-000455?papetoc

**JAMA Intern Med- Antidepressant Dose, Age, and the Risk of Deliberate Self-harmhttp://archinte.jamanetwork.com/article.aspx?articleid=1863925- The Comparative Clinical Effectiveness and Value of Simeprevir and Sofosbuvir for Chronic Hepatitis C Virus Infectionhttp://archinte.jamanetwork.com/article.aspx?articleid=1867174

**J Clin Onc- Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guidelinehttp://jco.ascopubs.org/content/early/2014/05/05/JCO.2013.54.0948.abstract- Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases: American Society of Clinical Oncology Clinical Practice Guidelinehttp://jco.ascopubs.org/content/early/2014/05/05/JCO.2013.54.0955.abstract

**J Crit CareComputerized physician order entry in the cardiac intensive care unit: effects on prescription errors and workflow conditions.http://www.sciencedirect.com/science/article/pii/S0883944113003961

**Lancet Infect DisEarly versus delayed initiation of highly active antiretroviral therapy for HIV-positive adults with newly diagnosed pulmonary tuberculosis (TB-HAART): a prospective, international, randomised, placebo-controlled trialhttp://www.thelancet.com/journals/laninf/article/PIIS1473-3099(14)70733-9/abstract

**NeurologySystematic review: Efficacy and safety of medical marijuana in selected neurologic disorders. Report of the Guideline Development Subcommittee of the American Academy of Neurologyhttp://www.neurology.org/content/82/17/1556.abstract

**NEJM- Antimicrobial Prophylaxis for Children with Vesicoureteral Refluxhttp://www.nejm.org/doi/full/10.1056/NEJMoa1401811- Darapladib for Preventing Ischemic Events in Stable Coronary Heart Diseasehttp://www.nejm.org/doi/full/10.1056/NEJMoa1315878- A Randomized Trial of Protocol-Based Care for Early Septic Shockhttp://www.nejm.org/doi/full/10.1056/NEJMoa1401602?query=infectious-disease- Editorial: Therapy of Hepatitis C — Back to the Futurehttp://www.nejm.org/doi/full/10.1056/NEJMe1403619

**PediatricsPrenatal SSRI Use and Offspring With Autism Spectrum Disorder or Developmental Delayhttp://pediatrics.aappublications.org/content/current

TAG Mail 30th April 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**AIHW- Incidence of insulin-treated diabetes in Australia 2000-2011http://www.aihw.gov.au/publication-detail/?id=60129546997- Australia's hospital statistics 2012-13http://www.aihw.gov.au/publication-detail/?id=60129546922- Australia's hospitals at a glance 2012-13 (summary report)http://www.aihw.gov.au/publication-detail/?id=60129547006

**BHI- Healthcare in Focus: the Bureau of Health Information’s 2013 Annual Performance Reporthttp://www.bhi.nsw.gov.au/publications/annual_performance_report_series/healthcare_in_focus_2013- The Insights Series: 30-day mortality following hospitalisation, five clinical conditions, NSW, July 2009 – 2012http://www.bhi.nsw.gov.au/__data/assets/pdf_file/0018/204309/30-day-Mortality_December2013.pdf

**Grattan Institute

Unlocking skills in hospitals: better jobs, more carehttp://grattan.edu.au/static/files/assets/cf2cf3cc/810-unlocking-skills-in-hospitals.pdf

**NHMRCTalking with your patients about Complementary Medicine – a Resource for Clinicianshttp://www.nhmrc.gov.au/your-health/complementary-medicines/talking-your-patients-about-complementary-medicine-resource-clin

**NHPAHealthcare-associated Staphylococcus aureus bloodstream infections in 2012–13http://www.myhospitals.gov.au/Content/Reports/sab/2014-03/pdf/HospitalPerformance_SAB_Infocus_2012_13.pdf

**NPSNPS Direct, April 2014, includes:- Statin use and haemorrhagic stroke- Emergency contraception: a weighty concern for women > 70 kg- Medicines in pregnancy — safe?- Low-dose quetiapine: place in therapy?http://www.nps.org.au/publications/health-professional/nps-direct/2014/april

**WCMICSAustralian consensus guidelines for the safe handling of monoclonal antibodies for cancer treatment by healthcare personnelhttp://www.wcmics.org/guidelines/20140422_MABs_Guidelines.pdf

REPORTS AND PUBLICATIONS - INTERNATIONAL**BCSHBritish Committee for Standards in Haematology. Guidelines for the diagnosis and management of multiple myeloma 2014http://www.bcshguidelines.com/documents/MYELOMA_GUIDELINE_Feb_2014_for_BCSH.pdf

**EMA2013 annual report on EudraVigilance: over 1 million adverse reaction reports received and processedhttp://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2014/04/news_detail_002088.jsp&mid=WC0b01ac058004d5c1

**FDA- FDA grants accelerated approval to Zykadia (ceritinib) for patients with a certain type of late-stage (metastatic) non-small cell lung cancer (NSCLC).http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm395299.htm- FDA approves Sylvant (siltuximab) to treat patients with multicentric

Castleman’s disease (MCD), a rare disorder similar to lymphoma.http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm394522.htm- FDA approves Cyramza (ramucirumab) to treat patients with advanced stomach cancer or gastroesophageal junction adenocarcinomahttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm394107.htm- FDA approves Tanzeum (albiglutide) subcutaneous injection to improve glycemic control, along with diet and exercise, in adults with type 2 diabetes.http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm393289.htm

**Joint Commission- Sentinel Event Statistics as of March, 2014http://www.jointcommission.org/sentinel_event_statistics_quarterly/- Sentinel Event Statistics Data - Root Causes by Event Type (2004 - 2013)http://www.jointcommission.org/Sentinel_Event_Statistics/- Sentinel Event Statistics Data - Event Type by Year (1995 - 2013)http://www.jointcommission.org/se_data_event_type_by_year_/

**NCPDP (US)National Council for Prescription Drug Programs Recommendations and Guidance for Standardizing the Dosing Designations on Prescription Container Labels of Oral Liquid Medicationshttps://www.ncpdp.org/NCPDP/media/pdf/wp/DosingDesignations-OralLiquid-MedicationLabels.pdf

**NICE- Quality Standards -- QS60 Induction of labour http://guidance.nice.org.uk/QS60-- QS61 Infection prevention and control http://guidance.nice.org.uk/QS61- Technology appraisals -- TA310 Lung cancer (non small cell, EGFR mutation positive) – afatinibhttp://guidance.nice.org.uk/TA310-- TA309 Lung cancer (non small cell, non squamous) – pemetrexedhttp://guidance.nice.org.uk/TA309-- TA311 Multiple myeloma - bortezomib (induction therapy) http://guidance.nice.org.uk/TA311

**NHS EvidenceEvidence Update - Venous thromboembolic diseases April 2014: A summary of selected new evidence relevant to NICE clinical guideline 144 ‘Venous thromboembolic diseases: the management of venous thromboembolic diseases and the role of thrombophilia testing’ (2012)http://arms.evidence.nhs.uk/resources/hub/1034187/attachment

**SIGNUpdated SIGN guidance: Antibiotic prophylaxis in surgeryhttp://www.sign.ac.uk/guidelines/fulltext/104/index.html

MEDICATION SAFETY**TGAAccu-Chek Mobile glucose tests: Recall for product correction - potential for the antibiotic ceftriaxone to interfere with blood glucose test resultshttp://www.tga.gov.au/safety/alerts-device-accu-chek-mobile-140422.htm

**Health CanadaProgressive Multifocal Leukoencephalopathy (PML) reported in patients receiving BENLYSTA (belimumab) for Systemic Lupus Erythematosus (SLE)http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/39189a-eng.php

**FDA- FDA requires label changes to warn of rare but serious neurologic problems after epidural corticosteroid injections for painhttp://www.fda.gov/Drugs/DrugSafety/ucm394280.htm- New Safety Measures Announced for Extended-release and Long-acting Opioidshttp://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/ucm363722.htm

**ISMPMedication Safety Newsletter: Disrespectful behaviors - Their impact, why they arise and persist, and how to address themhttp://www.ismp.org/Newsletters/acutecare/showarticle.aspx?id=78

**ISMP Canada Alert: Wrong Route Incidents with Epinephrinehttp://www.ismp-canada.org/download/safetyBulletins/2014/ISMPCSB2014-4_Epinephrine.pdf#page=1

**MHRADomperidone: risk of cardiac side effects - restricted indication, new contraindications, and reduced dose and duration of usehttps://www.cas.dh.gov.uk/ViewandAcknowledgment/ViewAlert.aspx?AlertID=102155

PAPERS OF INTEREST**BMJ- Incretin based drugs and risk of acute pancreatitis in patients with type 2 diabetes: cohort studyhttp://www.bmj.com/content/348/bmj.g2780- The impact of antibiotics on growth in children in low and middle income countries: systematic review and meta-analysis of randomised controlled

trialshttp://www.bmj.com/content/348/bmj.g2267- Chronic hypertension and pregnancy outcomes: systematic review and meta-analysishttp://www.bmj.com/content/348/bmj.g2301

**BMJ Qual SafSafety measurement and monitoring in healthcare: a framework to guide clinical teams and healthcare organisations in maintaining safetyhttp://qualitysafety.bmj.com/content/early/2014/04/23/bmjqs-2013-002757.short?g=w_qs_ahead_tab

**Br J PsychInterventions for reducing benzodiazepine use in older people: meta-analysis of randomised controlled trialshttp://bjp.rcpsych.org/content/204/2/98.abstract

**Can J DiabetesSafe and Appropriate Use of Insulin and Other Antihyperglycemic Agents in Hospitalhttp://www.sciencedirect.com/science/article/pii/S1499267114000033

**Circulation- Periprocedural Stroke and Bleeding Complications in Patients undergoing Catheter Ablation of Atrial Fibrillation with Different Anticoagulation Management: Results from the "COMPARE" Randomized Trialhttp://circ.ahajournals.org/content/early/2014/04/17/CIRCULATIONAHA.113.006426.abstract- Periprocedural Management of New Oral Anticoagulants in Patients Undergoing Atrial Fibrillation Ablationhttp://circ.ahajournals.org/content/129/16/1688.full

**Eur Heart JExpert position paper on the management of antiplatelet therapy in patients undergoing coronary artery bypass graft surgeryhttp://eurheartj.oxfordjournals.org/content/early/2014/04/18/eurheartj.ehu158.full

**Eur J Hosp Pharm- Potential drug interactions and side effects in an outpatient oncology clinic: a retrospective descriptive studyhttp://ejhp.bmj.com/content/early/2014/04/28/ejhpharm-2014-000449?papetoc- Teicoplanin usage in adult patients with haematological malignancy in the UK and Ireland: Is there scope for improvement?http://ejhp.bmj.com/content/early/2014/04/15/ejhpharm-2013-000412.abstract

**Lancet Inf Dis

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutionshttp://www.thelancet.com/journals/laninf/article/PIIS1473-3099(14)70036-2/abstract

**JAMA- Effect of the Use of Ambulance-Based Thrombolysis on Time to Thrombolysis in Acute Ischemic Stroke: A Randomized Clinical Trialhttp://jama.jamanetwork.com/article.aspx?articleid=1861800- Door-to-Needle Times for Tissue Plasminogen Activator Administration and Clinical Outcomes in Acute Ischemic Stroke Before and After a Quality Improvement Initiativehttp://jama.jamanetwork.com/article.aspx?articleid=1861802- Editorial: tPA for Stroke: Important Progress in Achieving Faster Treatmenthttp://jama.jamanetwork.com/article.aspx?articleid=1861774- Lorazepam vs Diazepam for Pediatric Status Epilepticus: A Randomized Clinical Trialhttp://jama.jamanetwork.com/article.aspx?articleid=1861799- Pharmacological Treatment of Parkinson Disease: A Reviewhttp://jama.jamanetwork.com/article.aspx?articleid=1861807

**JAMA Intern MedAntihypertensive Medications and Serious Fall Injuries in a Nationally Representative Sample of Older Adultshttp://archinte.jamanetwork.com/article.aspx?articleid=1832197

**PediatricsPrenatal SSRI Use and Offspring With Autism Spectrum Disorder or Developmental Delayhttp://pediatrics.aappublications.org/content/early/2014/04/09/peds.2013-3406.abstract

TAG Mail 16th April 2014

REPORTS AND PUBLICATIONS - AUSTRALIA

**NHMRC- Ethical Considerations in Quality Assurance and Evaluation Activitieshttp://www.nhmrc.gov.au/guidelines/publications/e111- Inclusion of advice on an opt-out approach, in the National Statement on Ethical Conduct in Human Research, 2007 (Chapter 2.3)http://www.nhmrc.gov.au/health-ethics/human-research-ethics/inclusion-advice-opt-out-approach-national-statement-ethical-con

**TGA

- Canesten 6 day cream 35 g: Recall - potential problem with plastic applicator http://www.tga.gov.au/safety/alerts-medicine-canesten-140414.htm- AusPARs added: Crizotinib (Xalkori); Ezetimibe and rosuvastatin (as calcium) (Ezalo Composite Pack / Rosuzet Composite Pack)http://www.tga.gov.au/industry/pm-auspar.htm

REPORTS AND PUBLICATIONS - INTERNATIONAL**BNF BNF/BNFC Update April 2014, includes:- Oral doses of amoxicillin and ampicillin for children updated- Changes to recommendations on interchangeability of oral mesalazine preparations - Doses of naloxone for opioid overdosage revised- Reminder on cytokine modulators and tuberculosis- Phosphate-containing eye drops and corneal calcificationhttp://www.pharmpress.com/mailouts/bnf/apr14/BNF_enewsletter.html

**NHS EvidenceEyes on Evidence April 2014, includes: - E-cigarette awareness and use to quit smoking - Beta-2 agonists and exercise-induced asthma Blood pressure control with home telemonitoring and pharmacist management- Antidepressant use late in pregnancy and risk of postpartum haemorrhagehttps://www.evidence.nhs.uk/eyes-on-evidence-april-2014.pdf

**NICEQuality Standard QS58: Sickle cell acute painful episodehttp://guidance.nice.org.uk/QS58

** WHO WHO guidelines for the screening, care and treatment of persons with hepatitis C infection http://www.who.int/hiv/pub/hepatitis/hepatitis-c-guidelines/en/

MEDICATION SAFETY**TGAMedtronic paradigm insulin pump: Safety advisory - risk of over-infusionhttp://www.tga.gov.au/safety/alerts-device-medtronic-paradigm-insulin-pump-140408.htm

**EMAPharmacovigilance Risk Assessment Committee (PRAC) recommends against combined use of medicines affecting the renin-angiotensin (RAS) systemhttp://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2014/04/WC500165197.pdf

**Health CanadaNeupogen (filgrastim) and Neulasta (pegfilgrastim) - Risk of Capillary Leak Syndrome http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/38893a-eng.php

**MHRADrug Safety Update April 2014, includes:- Tumour necrosis factor alpha inhibitors: risk of tuberculosis—screen all patients before starting treatment and monitor them closely- Yellow Card Scheme update: Reporting suspected adverse reactions experienced by the woman or child associated with medicines taken during pregnancy- Dispensing errors: please ensure appropriate precautions are in placehttp://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/

**NHS England- Patient Safety Alert, Stage One - Warning: Residual anaesthetic drugs in cannulae and intravenous lineshttp://www.england.nhs.uk/2014/04/14/pat-safety-alert/- Patient Safety Alert, Stage One - Warning: Minimising risks of omitted and delayed medicines for patients receiving homecare serviceshttp://www.england.nhs.uk/2014/04/10/psa-min-risks/

PAPERS OF INTEREST**Arthritis RheumMethotrexate and Lung Disease in Rheumatoid Arthritis: A Meta-Analysis of Randomized Controlled Trialshttp://onlinelibrary.wiley.com/doi/10.1002/art.38322/abstract

**BMJ- Zanamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory commentshttp://www.bmj.com/content/348/bmj.g2547- Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory commentshttp://www.bmj.com/content/348/bmj.g2545- Editorial: Neuraminidase inhibitors for influenzahttp://www.bmj.com/content/348/bmj.g2548

**BMJ OpenNon-steroidal anti-inflammatory drugs and the risk of atrial fibrillation: a population-based follow-up studyhttp://bmjopen.bmj.com/content/4/4/e004059

**BMJ Qual Saf- Are interventions to reduce interruptions and errors during medication administration effective? a systematic reviewhttp://qualitysafety.bmj.com/content/23/5/414?etoc

- Computerised provider order entry combined with clinical decision support systems to improve medication safety: a narrative reviewhttp://qualitysafety.bmj.com/content/early/2014/04/12/bmjqs-2013-002165.abstract

**Eur Heart JBalancing stroke and bleeding risks in patients with atrial fibrillation and renal failure: the Swedish Atrial Fibrillation Cohort studyhttp://eurheartj.oxfordjournals.org/content/early/2014/04/09/eurheartj.ehu139.abstract

**Circulation- Antiplatelet Therapy for Stable Coronary Artery Disease in Atrial Fibrillation Patients Taking an Oral Anticoagulant. A Nationwide Cohort Studyhttp://circ.ahajournals.org/content/129/15/1577.abstract?etoc- Variations in Cause and Management of Atrial Fibrillation in a Prospective Registry of 15 400 Emergency Department Patients in 46 Countries: The RE-LY Atrial Fibrillation Registryhttp://circ.ahajournals.org/content/129/15/1568.abstract?etoc

**Diabetes CareThe Efficacy and Safety of Imeglimin as Add-on Therapy in Patients With Type 2 Diabetes Inadequately Controlled With Sitagliptin Monotherapy http://care.diabetesjournals.org/content/early/2014/04/07/dc13-2349.abstract

**Int J Qual HealthcareStandardization in patient safety: the WHO High 5s projecthttp://intqhc.oxfordjournals.org/content/26/2/109.full.pdf+html

**JAMA- Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors vs Conventional Chemotherapy in Non–Small Cell Lung Cancer Harboring Wild-Type Epidermal Growth Factor Receptor: A Meta-analysishttp://jama.jamanetwork.com/article.aspx?articleid=1857337- Effect of Metformin on Left Ventricular Function After Acute Myocardial Infarction in Patients Without Diabetes: The GIPS-III Randomized Clinical Trialhttp://jama.jamanetwork.com/article.aspx?articleid=1853892

**JAMA Intern Med- Bleeding Risk of Patients With Acute Venous Thromboembolism Taking Nonsteroidal Anti-Inflammatory Drugs or Aspirinhttp://archinte.jamanetwork.com/article.aspx?articleid=1860497- Reduction of Inappropriate Benzodiazepine Prescriptions Among Older Adults Through Direct Patient Education: The EMPOWER Cluster Randomized Trialhttp://archinte.jamanetwork.com/article.aspx?articleid=1860498

- Sildenafil Use and Increased Risk of Incident Melanoma in US Men: A Prospective Cohort Studyhttp://archinte.jamanetwork.com/article.aspx?articleid=1857095**J Clin OncPrevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guidelinehttp://jco.ascopubs.org/content/early/2014/04/09/JCO.2013.54.0914.abstractScreening, Assessment, and Care of Anxiety and Depressive Symptoms in Adults With Cancer: An American Society of Clinical Oncology Guideline Adaptationhttp://jco.ascopubs.org/content/early/2014/04/09/JCO.2013.52.4611.abstractScreening, Assessment, and Management of Fatigue in Adult Survivors of Cancer: An American Society of Clinical Oncology Clinical Practice Guideline Adaptationhttp://jco.ascopubs.org/content/early/2014/04/09/JCO.2013.53.4495.abstract

**MJAMultidrug-resistant tuberculosis in Western Australia, 1998–2012https://www.mja.com.au/journal/2014/200/6/multidrug-resistant-tuberculosis-western-australia-1998-2012

**NEJM- Spironolactone for Heart Failure with Preserved Ejection Fractionhttp://www.nejm.org/doi/full/10.1056/NEJMoa1313731- Fibrinolysis for Patients with Intermediate-Risk Pulmonary Embolismhttp://www.nejm.org/doi/full/10.1056/NEJMoa1302097

**Pediatrics- American Academy of Pediatrics Policy Statement: Off-Label Use of Drugs in Childrenhttp://pediatrics.aappublications.org/content/133/3/563.full.pdf+html

TAG Mail 9th April 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**AIHWNational Aged Care Data Clearinghouse now available: an independent and centralised repository of national aged care data, which provides access to aged care information or custom aged care data on request.http://www.aihw.gov.au/national-aged-care-data-clearinghouse/

**TGA

- EMA and Australian regulatory authority strengthen collaboration in the area of orphan medicineshttp://www.tga.gov.au/newsroom/media-2014-ema-orphan-medicines-140407.htm- AusPARs added: Aminolevulinic acid HCl (Gliolan) and Deferasirox (Exjade)http://www.tga.gov.au/industry/pm-auspar.htm

**NPSNPS RADAR: Glycopyrronium (Seebri) for chronic obstructive pulmonary diseasehttp://www.nps.org.au/publications/health-professional/nps-radar/latest-issue/glycopyrronium

REPORTS AND PUBLICATIONS - INTERNATIONAL**CADTH- Issues in Emerging Health Technologies: Laquinimod for Relapsing-Remitting Multiple Sclerosis http://www.cadth.ca/media/pdf/EH0010_Laquinimod_for_MS_e.pdf- Rapid Response report: Vitamin Supplementation for Hospitalized Adults: Clinical Evidence and Guidelineshttp://www.cadth.ca/media/pdf/htis/apr-2014/RB0664%20Vitamin%20Supplementation%20for%20Inpatients%20Final.pdf

**CDCHealthcare-associated Infections (HAI) Progress Report, March 2014 (2102 data)http://www.cdc.gov/hai/progress-report/index.html

**CPSIMaking Care Safer, From Hospital to Home Care: A collaborative report fromAccreditation Canada and the Canadian Patient Safety Institutehttp://www.patientsafetyinstitute.ca/English/toolsResources/patientSafetyPublications/Documents/Making%20Care%20Safer%20From%20Hospital%20to%20Home%20Care.pdf

**FDAFDA approves new hand-held auto-injector to reverse opioid overdose -first naloxone treatment specifically designed to be given by family members or caregivershttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm391465.htm

MEDICATION SAFETY**TGA- Hydroxyethyl starch (Voluven and Volulyte): Safety advisory - increased risk of mortality and the need for dialysis in patients with sepsishttp://www.tga.gov.au/safety/alerts-medicine-hydroxyethyl-starch-

140404.htm- Bexsero meningococcal B vaccine: Monitoring communication - consumers and health professionals are advised that the TGA is undertaking intensive monitoring of the safety and risk profile of Bexsero meningococcal B vaccine following its introduction to the Australian market.http://www.tga.gov.au/safety/ews-medicine-bexsero-140402.htm- Domperidone (Motilium) and effects on the heart: Monitoring communication- the TGA is reviewing new information regarding domperidone (Motilium) and its potential effects on the patient's heart, particularly with doses above 30 mg daily.http://www.tga.gov.au/safety/ews-medicine-domperidone-140402.htm

**Health CanadaAssociation of vemurafenib (ZELBORAF®) Use with Drug Induced Liver Injuryhttp://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/38867a-eng.php

PAPERS OF INTEREST**Ann Intern Med- Low-Dose Aspirin for Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force http://annals.org/article.aspx?articleid=1859300- The Incidence and Determinants of Primary Nonadherence With Prescribed Medication in Primary Care: A Cohort Study http://annals.org/article.aspx?articleid=1852865- Effectiveness of Combination Therapy With Statin and Another Lipid-Modifying Agent Compared With Intensified Statin Monotherapy: A Systematic Reviewhttp://annals.org/article.aspx?articleid=1828554

**BMJ- Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trialshttp://www.bmj.com/content/348/bmj.g2035- Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studieshttp://www.bmj.com/content/348/bmj.g1903- Selective digestive or oropharyngeal decontamination and topical oropharyngeal chlorhexidine for prevention of death in general intensive care: systematic review and network meta-analysishttp://www.bmj.com/content/348/bmj.g2197- Causes and patterns of readmissions in patients with common comorbidities: retrospective cohort studyhttp://www.bmj.com/content/347/bmj.f7171

**Cochrane- Combined oral contraceptives: venous thrombosis

http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010813.pub2/full- Combined oral contraceptives: the risk of myocardial infarction and ischemic strokehttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011054/abstract- Antidepressants for the treatment of depression in patients with cancerhttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011006/abstract- Darbepoetin for the anaemia of chronic kidney diseasehttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009297.pub2/abstract- Direct thrombin inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in people with non-valvular atrial fibrillationhttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009893.pub2/abstract- Long-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: a network meta-analysishttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010844.pub2/abstract- Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary diseasehttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010115.pub2/full- Pharmacotherapies for sleep disturbances in Alzheimer's diseasehttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009178.pub2/abstract- Antibiotic prophylaxis for preventing post solid organ transplant tuberculosishttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008597.pub2/full- Paroxetine versus other anti-depressive agents for depressionhttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006531.pub2/abstract

**Eur J Hosp Pharm- The rate and nature of medication errors among elderly upon admission to hospital after implementation of clinical pharmacist-led medication reconciliationhttp://ejhp.bmj.com/content/early/2014/04/04/ejhpharm-2013-000403?papetoc- Physicochemical compatibility of commonly used analgesics and sedatives in the intensive care medicinehttp://ejhp.bmj.com/content/early/2014/04/04/ejhpharm-2014-000444.abstract- Improving the efficiency of a hospital pharmacy service: the journey of one hospital pharmacyhttp://ejhp.bmj.com/content/early/2014/04/04/ejhpharm-2013-000429.abstract

**Int J Clin PharmDrug related problems identified by community pharmacists on hospital discharge prescriptions in New Zealandhttp://link.springer.com/article/10.1007/s11096-014-9935-8

**JAMA Intern Med- Histamine-2 Receptor Antagonists vs Proton Pump Inhibitors on Gastrointestinal Tract Hemorrhage and Infectious Complications in the Intensive Care Unithttp://archinte.jamanetwork.com/article.aspx?articleid=1830021 - Antihypertensive Medications and Serious Fall Injuries in a Nationally Representative Sample of Older Adultshttp://archinte.jamanetwork.com/article.aspx?articleid=1832197 - Outbreak of Bacteremia Due to Burkholderia contaminans Linked to Intravenous Fentanyl From an Institutional Compounding Pharmacyhttp://archinte.jamanetwork.com/article.aspx?articleid=1819575 - National estimates of insulin-related hypoglycemia and errors leading to emergency department visits and hospitalizationshttp://archinte.jamanetwork.com/article.aspx?articleid=1835360

**J Am Med Inform Assoc - Appropriateness of commercially available and partially customized medication dosing alerts among pediatric patientshttp://jamia.bmj.com/content/21/e1/e35

**J Particip MedDo You Hear What I Hear? Communication Practices about Medications Between Physicians and Clients with Chronic Illness in Canadahttp://www.jopm.org/evidence/research/2014/01/15/do-you-hear-what-i-hear-communication-practices-about-medications-between-physicians-and-clients-with-chronic-illness-in-canada/

**J Pain Symptom ManagVariation of Opioid Use in Pediatric Inpatients Across Hospitals in the United Stateshttp://www.sciencedirect.com/science/article/pii/S0885392414001511

**Lancet Diabetes EndocrinExenatide once weekly versus insulin glargine for type 2 diabetes (DURATION-3): 3-year results of an open-label randomised trialhttp://www.thelancet.com/journals/landia/article/PIIS2213-8587(14)70029-4/abstract

**Lancet Infect DisNew antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospectshttp://www.thelancet.com/journals/laninf/article/PIIS1473-3099(13)70328-1/fulltext

**MJACase Report: Impact of drug interactions when medications are stopped: the often forgotten riskshttps://www.mja.com.au/journal/2014/200/6/impact-drug-interactions-

when-medications-are-stopped-often-forgotten-risks

TAG Mail 2nd April 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**TGA- TGA reforms: A blueprint for TGA's future: Progress report as at 31 December 2013http://www.tga.gov.au/about/tga-reforms-blueprint-progress-131231.htm- AusPARs added: Abiraterone acetate (Zytiga), Adalimumab (Humira), Besifloxacin hydrochloride (Besivance), Canagliflozin (as hemihydrate), Invokana (Prominad), Denosumab (Prolia), Imatinib (Glivec), Influenza virus haemagglutinin inactivated split influenza vaccine (Fluarix Tetra) and Japanese Encephalitis Vaccine (live, attenuated) (Imojev)http://www.tga.gov.au/industry/pm-auspar.htm

REPORTS AND PUBLICATIONS - INTERNATIONAL**AHRQMedication Administration Errors in Hospitals — Challenges and Recommendations for Their Measurementhttp://www.qualitymeasures.ahrq.gov/expert/expert-commentary.aspx?f=rss&id=47856

**FDA- FDA approves topiramate (Topamax) for migraine prevention in adolescents(First approved treatment for ages 12 to 17)http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm391026.htm- FDA clarifies Warning about Pediatric Use of Revatio (sildenafil) for Pulmonary Arterial Hypertensionhttp://www.fda.gov/Drugs/DrugSafety/ucm390876.htm

**NICE- Audit reveals variation in use of pain relief for hip fracturehttp://www.nice.org.uk/newsroom/news/AuditRevealsVariationUsePainReliefHipFracture.jsp- Evidence Summaries: New Medicines:-- ESNM39 Schizophrenia: aripiprazole prolonged-release suspension for injectionhttp://www.nice.org.uk/mpc/evidencesummariesnewmedicines/ESNM39.jsp-- ESNM38 Induction of labour: misoprostol vaginal delivery systemhttp://www.nice.org.uk/mpc/evidencesummariesnewmedicines/ESNM38.jsp- Evidence summary: unlicensed or off-label medicine:-- ESUOM30 Pouchitis: rifaximinhttp://www.nice.org.uk/mpc/

evidencesummariesunlicensedofflabelmedicines/ESUOM30.jsp- Technology Appraisals:-- TA307 Aflibercept in combination with irinotecan and fluorouracil-based therapy for treating metastatic colorectal cancer that has progressed following prior oxaliplatin-based chemotherapyhttp://guidance.nice.org.uk/TA307-- TA308 Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitishttp://guidance.nice.org.uk/TA308

MEDICATION SAFETY**TGAMedicines Safety Update, April 2014. Includes:- Olmesartan and sprue-like enteropathy- Codeine use in children after tonsillectomy and/or adenoidectomy- Methoxyflurane and occupational exposurehttp://www.tga.gov.au/hp/msu-2014-04.htm

**Health Canada- Association of mirtazapine with QT Prolongation/Torsades de Pointeshttp://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/38709a-eng.php- Association of azathioprine or mercaptopurine with Hepatosplenic T-Cell Lymphoma (HSTCL)http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/38691a-eng.php

**ISMPStill outside the bull’s eye: 2014-2015 Targeted Medication Safety Best Practices (baseline survey results)http://www.ismp.org/Newsletters/acutecare/showarticle.aspx?id=76

PAPERS OF INTEREST**Am J Health Syst PharmVariations in pharmacy-based transition-of-care activities in the United States: A national surveyhttp://www.ajhp.org/cgi/content/abstract/71/8/648?etoc

**BMC MedicineUnintended effects of statins from observational studies in the general population: systematic review and meta-analysishttp://www.biomedcentral.com/1741-7015/12/51

**Can J CardiolRecent Advances in Antidotes for Direct Oral Anticoagulants: Their Arrival Is Imminenthttp://www.sciencedirect.com/science/article/pii/S0828282X14000476

**Circulation- 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillationhttp://circ.ahajournals.org/content/early/2014/03/27/CIR.0000000000000041.full.pdf%20html- National Assessment of Warfarin Anticoagulation Therapy for Stroke Prevention in Atrial Fibrillation http://circ.ahajournals.org/content/129/13/1407.abstract- Lack of Concordance between Empirical Scores and Physician Assessments of Stroke and Bleeding Risk in Atrial Fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry http://circ.ahajournals.org/content/early/2014/03/20/CIRCULATIONAHA.114.008643.abstract- Five-Year Survival in Patients with ST-Segment Elevation Myocardial Infarction According to Modalities of Reperfusion Therapy: The French Registry on Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) 2005 Cohorthttp://circ.ahajournals.org/content/early/2014/03/21/CIRCULATIONAHA.113.005874.abstract

**Int J Med InformaticsE-prescribing errors in community pharmacies: Exploring consequences and contributing factorshttp://www.sciencedirect.com/science/article/pii/S1386505614000434

**JAMA- Validation of the Atherosclerotic Cardiovascular Disease Pooled Cohort Risk Equationshttp://jama.jamanetwork.com/article.aspx?articleid=1853203- Effect of Metformin on Left Ventricular Function After Acute Myocardial Infarction in Patients Without Diabetes: The GIPS-III Randomized Clinical Trialhttp://jama.jamanetwork.com/article.aspx?articleid=1853892- Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, 2000-2012http://jama.jamanetwork.com/article.aspx?articleid=1850096- Comparison of Application of the ACC/AHA Guidelines, Adult Treatment Panel III Guidelines, and European Society of Cardiology Guidelines for Cardiovascular Disease Prevention in a European Cohorthttp://jama.jamanetwork.com/article.aspx?articleid=1853204

**JAMA Intern MedEffect of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on All-Cause Mortality, Cardiovascular Deaths, and Cardiovascular Events in Patients with Diabetes Mellitus: A Meta-analysishttp://archinte.jamanetwork.com/article.aspx?articleid=1847572

**MJA

Staphylococcus aureus bloodstream infection in Australian hospitals: findings from a Victorian surveillance system.https://www.mja.com.au/journal/2014/200/5/staphylococcus-aureus-bloodstream-infection-australian-hospitals-findings

**NEJM- Aspirin in Patients Undergoing Noncardiac Surgeryhttp://www.nejm.org/doi/full/10.1056/NEJMoa1401105?query=featured_home - Clonidine in Patients Undergoing Noncardiac Surgeryhttp://www.nejm.org/doi/full/10.1056/NEJMoa1401106- Multistate Point-Prevalence Survey of Health Care–Associated Infectionshttp://www.nejm.org/doi/full/10.1056/NEJMoa1306801 - A 52-Week Placebo-Controlled Trial of Evolocumab in Hyperlipidemiahttp://www.nejm.org/doi/full/10.1056/NEJMoa1316222

**Lancet- Once-daily dolutegravir versus darunavir plus ritonavir in antiretroviral-naive adults with HIV-1 infection (FLAMINGO): 48 week results from the randomised open-label phase 3b studyhttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)60084-2/abstract - Efficacy and safety of colchicine for treatment of multiple recurrences of pericarditis (CORP-2): a multicentre, double-blind, placebo-controlled, randomised trialhttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)62709-9/abstract

**PediatricsCeftriaxone and Acute Renal Failure in Childrenhttp://pediatrics.aappublications.org/content/133/4/e917.abstract

TAG Mail 26th March 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**AIHWHealth expenditure Australia 2011-12: analysis by sectorhttp://www.aihw.gov.au/publication-detail/?id=60129546642

**CECFour new Clinical Focus Reports have been published:– Falls- Retrieval and Inter-Hospital Transfer- Patient Controlled Analgesia- A Review of Acute Coronary Syndrome Incidentshttp://www.cec.health.nsw.gov.au/programs/patient-safety#publications2

**NSW HealthGoods and Services Procurement Policyhttp://www0.health.nsw.gov.au/policies/pd/2014/pdf/PD2014_005.pdf

REPORTS AND PUBLICATIONS - INTERNATIONAL**FDAFDA approves Otezla (apremilast) to treat adults with active psoriatic arthritishttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm390091.htm

**NICE- Evidence Summaries: New Medicines-- ESNM37: Partial seizures in children and young people with epilepsy: zonisamide as adjunctive therapyhttp://publications.nice.org.uk/esnm37-partial-seizures-in-children-and-young-people-with-epilepsy-zonisamide-as-adjunctive-esnm37-- ESNM36: Systemic juvenile idiopathic arthritis: canakinumabhttp://www.nice.org.uk/mpc/evidencesummariesnewmedicines/ESNM36.jsp- Evidence summary: unlicensed or off-label medicine -- ESUOM29: Difficult-to-treat scabies: oral ivermectinhttp://publications.nice.org.uk/esuom29-difficult-to-treat-scabies-oral-ivermectin-esuom29

MEDICATION SAFETY**ISMP CanadaAdvancing Opioid Safety for Children in Hospitalshttp://www.ismp-canada.org/download/safetyBulletins/2014/ISMPCSB2014-3_HospitalOpioidSafetyForChildren.pdf#page=1

**MHRAPatient Safety Alert, Stage Three: Directive - Improving medication error incident reporting and learninghttp://www.england.nhs.uk/wp-content/uploads/2014/03/psa-med-error.pdf

PAPERS OF INTEREST**Am Heart JPhysician practices regarding contraindications to oral anticoagulation in atrial fibrillation: Findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registryhttp://www.sciencedirect.com/science/article/pii/S0002870314000076

**BMJ- Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: retrospective cohort studyhttp://www.bmj.com/content/348/bmj.g1996- Antidepressant efficacy of agomelatine: meta-analysis of published and

unpublished studieshttp://www.bmj.com/content/348/bmj.g1888

**BMJ Qual SafIdentifying systems failures in the pathway to a catastrophic event: an analysis of national incident report data relating to vinca alkaloidshttp://qualitysafety.bmj.com/content/early/2014/03/18/bmjqs-2013-002572.full.pdf+html

**CirculationSTARTS-2: Long-Term Survival With Oral Sildenafil Monotherapy in Treatment-Naïve Pediatric Pulmonary Arterial Hypertensionhttp://circ.ahajournals.org/content/early/2014/03/17/CIRCULATIONAHA.113.005698.abstract

**Eur Heart J- The association between older age and receipt of care and outcomes in patients with acute coronary syndromes: a cohort study of the Myocardial Ischaemia National Audit Project (MINAP)http://eurheartj.oxfordjournals.org/content/early/2014/03/17/eurheartj.ehu039.abstract- Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: results from the ROCKET AF trialhttp://eurheartj.oxfordjournals.org/content/early/2014/03/20/eurheartj.ehu083.abstract.html?papetoc

**JAMA- Ezetimibe Prescribing Fails to Keep Up With Evidencehttp://jama.jamanetwork.com/article.aspx?articleid=1850961- The perpetual challenge of antimicrobial resistancehttp://jama.jamanetwork.com/article.aspx?articleid=1851734

**JAMIADesign and usability study of an iconic user interface to ease information retrieval of medical guidelineshttp://jamia.bmj.com/content/early/2014/03/20/amiajnl-2012-001548.short?g=w_jamia_ahead_tab

*Lancet Resp Med- Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant datahttp://www.thelancet.com/journals/lancet/article/PIIS2213-2600(14)70041-4/fulltext- Atorvastatin as a stable treatment in bronchiectasis: a randomised controlled trialhttp://www.thelancet.com/journals/lanres/article/PIIS2213-2600(14)70050-5/abstract

**NEJMRibavirin for Chronic Hepatitis E Virus Infection in Transplant Recipientshttp://www.nejm.org/doi/full/10.1056/NEJMoa1215246?query=TOC

TAG Mail 19th March 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**NSW HealthSnakebite and Spiderbite Clinical Management Guidelines 2013 - Third Editionhttp://www0.health.nsw.gov.au/policies/gl/2014/GL2014_005.html

**TGA- Review of the colouring substance tartrazinehttp://www.tga.gov.au/newsroom/media-2014-tartrazine-140317.htm- Common list of colouring substances publishedhttp://www.tga.gov.au/newsroom/media-2014-colouring-140317.htm- AusPARs added Tocilizumab (Actemra)http://www.tga.gov.au/industry/pm-auspar.htm

**ACSQHC- Accreditation Workbook for Mental Health Serviceshttp://www.safetyandquality.gov.au/publications/accreditation-workbook-mental-health-services/- National Round Table Report on Improving the Safety and Quality of Pharmacy Dispensing Labelshttp://www.safetyandquality.gov.au/publications/national-round-table-report-on-improving-the-safety-and-quality-of-pharmacy-dispensing-labels/ REPORTS AND PUBLICATIONS - INTERNATIONAL**CADTH Rapid Response Report: Bolused (Vice Infused) Tranexamic Acid in Adults Experiencing Hemorrhagic Shock: Safety, Patient Benefits, and Guidelineshttp://www.cadth.ca/media/pdf/htis/mar-2014/RB0652%20Bolused%20Tranexamic%20Acid%20Final.pdf

**IHI“Always Events” Getting Started Kithttp://www.ihi.org/resources/Pages/Tools/AlwaysEventsGettingStartedKit.aspx

**MHRAEarly access to medicines scheme announced: The new scheme aims to give patients in the UK with life threatening or seriously debilitating conditions access to medicines that do not yet have a marketing authorisation.

http://www.mhra.gov.uk/NewsCentre/CON392899

**NICEEyes on Evidence, March 2014. Includes: - Oral contraceptive pills in preventing ovarian; - Tamsulosin for benign prostatic hyperplasia and risk of severe hypotension.https://www.evidence.nhs.uk/eyes-on-evidence-march-2014.pdf

MEDICATION SAFETY**TGAMonitoring communication: Natalizumab and melanoma. The TGA is monitoring reports of melanoma in patients being treated with natalizumab and encourages reporting of all such cases. http://www.tga.gov.au/safety/ews-medicine-natalizumab-melanoma-140318.htm

**ISMPRecommendations for practitioners and manufacturers to address system-based causes of vaccine errorshttp://www.ismp.org/Newsletters/acutecare/showarticle.aspx?id=74

**MHRADrug Safety Update March 2014, includes:- Orlistat: theoretical interaction with antiretroviral HIV medicines;- St John’s wort: interaction with hormonal contraceptives, including implants—reduced contraceptive effect; - Strontium ranelate: cardiovascular risk—restricted indication and new monitoring requirements; - Methysergide: serious fibrotic reactions—restricted use and new monitoring requirements; - Combined hormonal contraceptives: risk of venous thromboembolism—clarification of advice.http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/index.htm

PAPERS OF INTEREST**Am J Health Syst Pharm- Comparison of injectable anticoagulants for thromboprophylaxis after cancer-related surgeryhttp://www.ajhp.org/content/71/7/562.abstract?etoc- Impact of shortages of injectable oncology drugs on patient carehttp://www.ajhp.org/content/71/7/571.abstract?etoc

**Ann Intern MedAssociation of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk: A Systematic Review and Meta-analysishttp://annals.org/article.aspx?articleid=1846638

**BMJNicotine patches in pregnant smokers: randomised, placebo controlled, multicentre trial of efficacyhttp://www.bmj.com/content/348/bmj.g1622

**Eur J Prev CardiolWhat proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug? Systematic review of randomized placebo-controlled trials to aid individual patient choicehttp://cpr.sagepub.com/content/early/2014/03/06/2047487314525531.abstract

**J Emerg MedAdverse Drug Event Nonrecognition in Emergency Departments: An Exploratory Study on Factors Related to Patients and Drugshttp://www.sciencedirect.com/science/article/pii/S0736467913014510

**NEJM- A Randomized Trial of Protocol-Based Care for Early Septic Shockhttp://www.nejm.org/doi/full/10.1056/NEJMoa1401602?query=featured_home- Albumin Replacement in Patients with Severe Sepsis or Septic Shockhttp://www.nejm.org/doi/full/10.1056/NEJMoa1305727?query=featured_home- High versus Low Blood-Pressure Target in Patients with Septic Shockhttp://www.nejm.org/doi/full/10.1056/NEJMoa1312173

**JAMAFactor Xa Inhibitors vs Warfarin for Preventing Stroke and Thromboembolism in Patients With Atrial Fibrillationhttp://jama.jamanetwork.com/article.aspx?articleid=1841952

**JAMA Intern Med- Nonleg Venous Thrombosis in Critically Ill Adults: A Nested Prospective Cohort Study http://archinte.jamanetwork.com/article.aspx?articleid=1835349- National Estimates of Insulin-Related Hypoglycemia and Errors Leading to Emergency Department Visits and Hospitalizationshttp://archinte.jamanetwork.com/article.aspx?articleid=1835360

**Lancet: CardiologyComparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trialshttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)62343-0/fulltext

**MJA- Increasing incidence of Clostridium difficile infection, Australia, 2011–

2012https://www.mja.com.au/journal/2014/200/5/increasing-incidence-clostridium-difficile-infection-australia-2011-2012 - Staphylococcus aureus bloodstream infection in Australian hospitals: findings from a Victorian surveillance systemhttps://www.mja.com.au/journal/2014/200/5/staphylococcus-aureus-bloodstream-infection-australian-hospitals-findings

TAG Mail 12th March 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**ACSQHCNational surveillance and reporting of antimicrobial resistance and antibiotic usage for human health in Australiahttp://www.safetyandquality.gov.au/publications/national-surveillance-and-reporting-of-antimicrobial-resistance-and-antibiotic-usage-for-human-health-in-australia **Grattan InstituteControlling costly care: a billion-dollar hospital opportunity, March 2014http://grattan.edu.au/static/files/assets/9b40e378/806-costly-care.pdf

**TGAInformation on 2014 seasonal influenza vaccineshttp://www.tga.gov.au/safety/media-2013-seasonal-flu-140311.htm

REPORTS AND PUBLICATIONS - INTERNATIONAL**CDCAntibiotic Rx in Hospitals: Proceed with Cautionhttp://www.cdc.gov/vitalsigns/pdf/2014-03-vitalsigns.pdf

**NICE- Evidence Summary: New Medicine-- ESNM35: Type 2 diabetes: empagliflozinhttp://publications.nice.org.uk/esnm35-type-2-diabetes-empagliflozin-esnm35- Evidence summary: unlicensed or off-label medicine-- ESUOM28: Rapid tranquillisation in mental health settings: promethazine hydrochloride http://publications.nice.org.uk/esuom28-rapid-tranquillisation-in-mental-health-settings-promethazine-hydrochloride-esuom28

**NHS EnglandPatient Safety Alert: Addressing rising trends and outbreaks in carbapenemase- producing Enterobacteriaceae

http://www.england.nhs.uk/2014/03/06/psa-enterobacteriaceae/

**Public Health EnglandAcute trust toolkit for the early detection, management and control of carbapenemase-producing Enterobacteriaceaehttp://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1317140378646

**PSQHMedication Reconciliation: Getting Started with IThttp://www.psqh.com/january-february-2014/1826-medication-reconciliation-getting-started-with-it

**WHOEnsuring Human Rights in the provision of contraceptive information and services: Guidance and recommendationshttp://www.who.int/reproductivehealth/publications/family_planning/human-rights-contraception/en/

MEDICATION SAFETY**EMA- The European Medicines Agency’s Pharmacovigilance Risk Assessment Committee (PRAC) recommends restricting use of domperidone: Benefits still considered to outweigh risks when given short-term and in low doses to treat nausea or vomitinghttp://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2014/03/WC500162558.pdf- PRAC recommends product information of zolpidem be updated with new advice to minimise the risk of next-morning impaired driving ability and mental alertnesshttp://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2014/03/WC500162556.pdf

**FDADoribax (doripenem): Drug Safety Communication - Risk When Used to Treat Pneumonia on Ventilated Patientshttp://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm388328.htm

PAPERS OF INTEREST**BMJUse of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis: nationwide cohort studyhttp://www.bmj.com/content/348/bmj.g1908

**CochraneOver-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adultshttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006088.pub4/abstract

**Diabetes CareOutcomes of Combined Cardiovascular Risk Factor Management Strategies in Type 2 Diabetes: The ACCORD Randomized Trialhttp://care.diabetesjournals.org/content/early/2014/02/27/dc13-2334.abstract

**Eur Heart JEffect of B-type natriuretic peptide-guided treatment of chronic heart failure on total mortality and hospitalization: an individual patient meta-analysishttp://eurheartj.oxfordjournals.org/content/early/2014/03/05/eurheartj.ehu090.abstract

**International Journal of Medical InformaticsThe impact of clinical leadership on health information technology adoption: systematic reviewhttp://www.sciencedirect.com/science/article/pii/S1386505614000446

**J Patient Saf- Who Do Hospital Physicians and Nurses Go to for Advice About Medications? A Social Network Analysis and Examination of Prescribing Error Rateshttp://journals.lww.com/journalpatientsafety/Abstract/publishahead/Who_Do_Hospital_Physicians_and_Nurses_Go_to_for.99780.aspx- Core Drug-Drug Interaction Alerts for Inclusion in Pediatric Electronic Health Records With Computerized Prescriber Order Entryhttp://journals.lww.com/journalpatientsafety/Abstract/2014/03000/Core_Drug_Drug_Interaction_Alerts_for_Inclusion_in.8.aspx

**JAMA Intern Med- National Estimates of Insulin-Related Hypoglycemia and Errors Leading to Emergency Department Visits and Hospitalizationshttp://archinte.jamanetwork.com/article.aspx?articleid=1835360- Warfarin Interactions With Antibiotics in the Ambulatory Care Settinghttp://archinte.jamanetwork.com/article.aspx?articleid=1813223 - Blood Culture Use in the Emergency Department in Patients Hospitalized for Community-Acquired Pneumoniahttp://archinte.jamanetwork.com/article.aspx?articleid=1835358

** Lancet: Diabetes and EndocrinologyEffects of sodium restriction and hydrochlorothiazide on RAAS blockade efficacy in diabetic nephropathy: a randomised clinical trialhttp://www.thelancet.com/journals/landia/article/PIIS2213-8587(14)70030-0/fulltext

**Lancet: CardiologyPrasugrel versus clopidogrel for patients with unstable angina or non-ST-segment elevation myocardial infarction with or without angiography: a

secondary, prespecified analysis of the TRILOGY ACS trialhttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61451-8/fulltext

**Ther Drug MonitEffect of Cyclosporine on Steady-State Pharmacokinetics of MPA in Renal Transplant Recipients Is Not Affected by the MPA Formulation: Analysis Based on Therapeutic Drug Monitoring Datahttp://journals.lww.com/drug-monitoring/Abstract/publishahead/Effect_of_Cyclosporine_on_Steady_State.99423.aspx

TAG Mail 5th March 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**TGA- Submissions and TGA response: Chloramphenicol, propamidine, dibromopropamidine and sulfacetamide for ophthalmic use: proposed advisory statements for medicineshttp://www.tga.gov.au/newsroom/consult-otc-chloramphenicol-131122-submissions.htm- Monitoring communication: Levonorgestrel 1.5 mg and 0.75 mg, oral emergency contraceptivehttp://www.tga.gov.au/safety/ews-medicine-levonorgestrel-140228.htm- AusPARs added: Alemtuzumab (rch) (Lemtrada, Remniq), Levonorgestrel (Jaydess) and Ruxolitinib (Jakavi)http://www.tga.gov.au/industry/pm-auspar.htm- Orphan drugs added: Anti-H5N1http://www.tga.gov.au/industry/pm-orphan-drugs.htm

REPORTS AND PUBLICATIONS - INTERNATIONAL**NICE- Evidence summary: new medicine:-- ESNM34: Asthma: fluticasone furoate/vilanterol (Relvar Ellipta) combination inhaler http://publications.nice.org.uk/esnm34-asthma-fluticasone-furoatevilanterol-relvar-ellipta-combination-inhaler-esnm34- Final Appraisal Determination:-- Lung cancer (non small cell, non squamous) - pemetrexed (maintenance following pemetrexed & cisplatin)http://guidance.nice.org.uk/TAG/309/FAD2- Quality Standards:-- QS55:Children and young people with cancer http://guidance.nice.org.uk/QS55-- QS56: Metastatic spinal cord compression http://guidance.nice.org.uk/QS56- Interventional Procedure Guideline:

-- IPG478: Electrochemotherapy for primary basal cell carcinoma and primary squamous cell carcinoma http://guidance.nice.org.uk/IPG478

**Nuffield Trust (UK)The Francis Report: one year on. The response of acute trusts in Englandhttp://www.nuffieldtrust.org.uk/sites/files/nuffield/publication/140206_the_francis_inquiry.pdf

MEDICATION SAFETY**ACSQHCMedication Safety Newsletter February 2014. Includes: Evidence briefings on interventions to improve medication safety; New Medication Safety Program web site; Literature Review: Medication Safety in Australia 2013; NIMC 2012 National Audit Reporthttp://www.safetyandquality.gov.au/wp-content/uploads/2012/01/Medication-Safety-Update-11-February-2014.pdf

**FDA- Acetaminophen Prescription Combination Drug Products with more than 325 mg: FDA Statement - Recommendation to Discontinue Prescribing and Dispensinghttp://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm381650.htm

**ISMPISMP Canada identifies themes associated with fatal medication events in the homehttp://www.ismp.org/Newsletters/acutecare/showarticle.aspx?id=72

**MHRAPress Release: Nearly one-third of parents in London fail to report drug side-effects experienced by their children to GPshttp://www.mhra.gov.uk/NewsCentre/Pressreleases/CON390434

PAPERS OF INTEREST**Age AgingAminoglycosides use in patients over 75 years oldhttp://ageing.oxfordjournals.org/content/early/2014/02/28/ageing.afu023.full.pdf?papetoc

**Am J Health Syst Pharm- Cost-minimization analysis of two fluid products for resuscitation of critically injured trauma patientshttp://www.ajhp.org/content/71/6/470.abstract- National trends in prescription drug expenditures and projections for 2014http://www.ajhp.org/content/71/6/482.abstract

**Ann Intern MedTreatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Disease Risk in Adults: Synopsis of the 2013 American College of Cardiology/American Heart Association Cholesterol Guidelinehttp://annals.org/article.aspx?articleid=1818923

**BMC Health Services ResearchA national survey of inpatient medication systems in English NHS hospitalshttp://www.biomedcentral.com/1472-6963/14/93/abstract

**BMJAssociations between palliative chemotherapy and adult cancer patients’ end of life care and place of death: prospective cohort studyhttp://www.bmj.com/content/348/bmj.g1219

**BMJ Qual SafMedication errors: do they occur in isolation?http://qualitysafety.bmj.com/content/early/2014/02/27/bmjqs-2014-002924.full

**Circulation- 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelineshttp://circ.ahajournals.org/content/early/2014/02/27/CIR.0000000000000031.full.pdf- Nonsteroidal Anti-Inflammatory Drugs and the Hearthttp://circ.ahajournals.org/content/129/8/907.full

**Eur Heart J- Efficacy and safety of apixaban compared with aspirin in patients who previously tried but failed treatment with vitamin K antagonists: results from the AVERROES trialhttp://eurheartj.oxfordjournals.org/content/early/2014/02/24/eurheartj.ehu048.abstract- Statin therapy and long-term adverse limb outcomes in patients with peripheral artery disease: insights from the REACH registryhttp://eurheartj.oxfordjournals.org/content/early/2014/02/27/eurheartj.ehu080.abstract

**JAMAWarfarin, Kidney Dysfunction, and Outcomes Following Acute Myocardial Infarction in Patients with Atrial Fibrillationhttp://jama.jamanetwork.com/article.aspx?articleid=1835505

**JAMA Intern Med- Association of β-Blocker Therapy with Risks of Adverse Cardiovascular Events and Deaths in Patients with Ischemic Heart Disease Undergoing Noncardiac Surgery: A Danish Nationwide Cohort Study

http://archinte.jamanetwork.com/article.aspx?articleid=1779729- Renoprotective Effect of Renin-Angiotensin-Aldosterone System Blockade in Patients With Predialysis Advanced Chronic Kidney Disease, Hypertension, and Anemiahttp://archinte.jamanetwork.com/article.aspx?articleid=1787693- Nudging Guideline-Concordant Antibiotic Prescribing: A Randomized Clinical Trialhttp://archinte.jamanetwork.com/article.aspx?articleid=1815102- Cognitive Function and Brain Structure in Persons With Type 2 Diabetes Mellitus After Intensive Lowering of Blood Pressure and Lipid Levels: A Randomized Clinical Trialhttp://archinte.jamanetwork.com/article.aspx?articleid=1819574

**J Onc Pharm Prac- Intravenous chemotherapy preparation errors: Patient safety risks identified in a pan-Canadian exploratory studyhttp://opp.sagepub.com/content/20/1/40.abstract- Medication safety and the administration of intravenous vincristine: International survey of oncology pharmacistshttp://opp.sagepub.com/content/early/2014/01/13/1078155213517729.abstract

**LancetPreoperative chemotherapy for non-small cell lung cancer: a systematic review and meta-analysis of individual participant datahttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)62159-5/abstract

**MJA- Clenbuterol toxicity: a NSW Poisons Information Centre experiencehttps://www.mja.com.au/journal/2014/200/4/clenbuterol-toxicity-nsw-poisons-information-centre-experience- Renal replacement therapy associated with lithium nephrotoxicity in Australiahttps://www.mja.com.au/journal/2014/200/4/renal-replacement-therapy-associated-lithium-nephrotoxicity-australia

**Pediatrics- Chemotherapy Drug Shortages in Pediatric Oncology: A Consensus Statementhttp://pediatrics.aappublications.org/content/133/3/e716- Pediatric Clinical Practice Guidelines for Acute Procedural Pain: A Systematic Reviewhttp://pediatrics.aappublications.org/content/133/3/500.abstract- Safety of Medical Interventions in Children Versus Adultshttp://pediatrics.aappublications.org/content/133/3/e666.abstract

TAG Mail 26th February 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**AIHW- Health care expenditure on cardiovascular diseases 2008-09http://www.aihw.gov.au/publication-detail/?id=60129546381- Type 2 diabetes in Australia's children and young people: a working paperhttp://www.aihw.gov.au/publication-detail/?id=60129546361

REPORTS AND PUBLICATIONS - INTERNATIONAL**CADTHRapid Response Reports:- Trientine for Treatment of Wilson’s Disease: Clinical and Cost-Effectiveness, and Safetyhttp://www.cadth.ca/media/pdf/htis/feb-2014/RA0660%20Trientine%20Final.pdf- Drug Interventions for Chronic Non-Cancer Pain: Guidelines and Recommendationshttp://www.cadth.ca/media/pdf/htis/feb-2014/RA0658%20Drugs%20for%20Chronic%20Non-Cancer%20Pain%20Final.pdf- Non-Drug Interventions for Chronic Non-Cancer Pain: Guidelines and Recommendationshttp://www.cadth.ca/media/pdf/htis/feb-2014/RA0659%20Non-drugs%20for%20Chronic%20Non-Cancer%20Pain%20Final.pdf

**NICE- Evidence summaries: unlicensed or off-label medicines:-- ESUOM26: Interstitial cystitis: dimethyl sulfoxide bladder instillationhttp://publications.nice.org.uk/esuom26-interstitial-cystitis-dimethyl-sulfoxide-bladder-instillation-esuom26-- ESUOM27 Chronic pain: oral ketaminehttp://www.nice.org.uk/mpc/evidencesummariesunlicensedofflabelmedicines/ESUOM27.jsp- Technology Appraisals:-- TA305 Macular oedema (central retinal vein occlusion) - aflibercept solution for injection http://guidance.nice.org.uk/TA305-- TA306 Non Hodgkin's lymphoma (relapsed refractory) - pixantrone monotherapy http://guidance.nice.org.uk/TA306

**FDAFDA approves Myalept (metreleptin for injection) as replacement therapy to treat the complications of leptin deficiency, in addition to diet, in patients with congenital generalized or acquired generalized lipodystrophyhttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm387060.htm

MEDICATION SAFETY**EMA- European Medicines Agency recommends restricting the use of methysergide-containing medicines: New recommendations follow concerns over association with fibrosishttp://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2014/02/WC500161952.pdf- European Medicines Agency recommends that Protelos/Osseor remain available but with further restrictionshttp://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2014/02/WC500161971.pdf- European Medicines Agency and US Food and Drug Administration strengthen collaboration in pharmacovigilance areahttp://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2014/02/news_detail_002028.jsp&mid=WC0b01ac058004d5c1

**Health CanadaNew safety information regarding Telzir (fosamprenavir calcium) used in the treatment of HIVhttp://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/38061a-eng.php

**ISMPNew standards for healthcare connectors - the "Stay Connected" program"http://www.ismp.org/tools/stayconnectedprogram.aspx

**NHS EnglandPatient Safety Alert: Stage Three Directive - Non-Luer spinal (intrathecal) devices for chemotherapy https://www.cas.dh.gov.uk/ViewandAcknowledgment/ViewAlert.aspx?AlertID=102114

**PrescrireNausea and vomiting: stop the use of domperidone once and for allhttp://english.prescrire.org/en/81/168/49205/0/NewsDetails.aspx

PAPERS OF INTEREST**Am J CardiolMeta-Analysis of Randomized Controlled Trials on the Risk of Bleeding With Dabigatranhttp://www.sciencedirect.com/science/article/pii/S000291491302448X

**Ann Intern MedVitamin, Mineral, and Multivitamin Supplements for the Primary Prevention of Cardiovascular Disease and Cancer: U.S. Preventive Services Task Force Recommendation Statementhttp://annals.org/article.aspx?articleid=1832969

**Ann Pharmacother

Impact of a Clinical Pharmacy Admission Medication Reconciliation Program on Medication Errors in “High-Risk” Patientshttp://aop.sagepub.com/content/47/12/1599

**BMJ OpenMedication use in pregnancy: a cross-sectional, multinational web-based studyhttp://bmjopen.bmj.com/content/4/2/e004365.full

**Cochrane- Safety of regular formoterol or salmeterol in adults with asthma: an overview of Cochrane reviewshttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010314.pub2/abstract- Anticonvulsants for alcohol dependencehttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008544.pub2/abstract

**Drug Saf- Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors: An Updatehttp://link.springer.com/article/10.1007/s40264-014-0144-0- Self-Medication with Over-the-Counter and Prescribed Drugs Causing Adverse-Drug-Reaction-Related Hospital Admissions: Results of a Prospective, Long-Term Multi-Centre Studyhttp://link.springer.com/article/10.1007/s40264-014-0141-3

**HeartHigh-potency statin and ezetimibe use and mortality in survivors of an acute myocardial infarction: a population-based studyhttp://heart.bmj.com/content/early/2014/02/19/heartjnl-2013-304678.abstract

**ThoraxSafety of tiotropium through the Handihaler: why did meta-analyses and database studies appear to give a false alarm?http://thorax.bmj.com/content/early/2014/02/18/thoraxjnl-2014-205155.full

**JAMA Intern MedAntihypertensive Medications and Serious Fall Injuries in a Nationally Representative Sample of Older Adultshttp://archinte.jamanetwork.com/article.aspx?articleid=1832197

** Lancet - Infliximab for intensification of primary therapy for Kawasaki disease: a phase 3 randomised, double-blind, placebo-controlled trialhttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)62298-9/abstract- Preoperative chemotherapy for non-small cell lung cancer: a systematic

review and meta-analysis of individual participant datahttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)62159-5/fulltext- Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trialhttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)62062-0/abstract

**NEJM- Improved Survival with Bevacizumab in Advanced Cervical Cancerhttp://www.nejm.org/doi/full/10.1056/NEJMoa1309748- Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastomahttp://www.nejm.org/doi/full/10.1056/NEJMoa1308345- A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastomahttp://www.nejm.org/doi/full/10.1056/NEJMoa1308573

TAG Mail 19th February 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**ACSQHC- National surveillance and reporting of antimicrobial resistance and antibiotic usage for human health in Australiahttp://www.safetyandquality.gov.au/publications/national-surveillance-and-reporting-of-antimicrobial-resistance-and-antibiotic-usage-for-human-health-in-australia/ - NIMC Audit System User Guidehttp://www.safetyandquality.gov.au/publications/national-inpatient-medication-chart-audit-system-user-guide/

**NPS NPS Direct February 2014Includes: Superbug stowaways: multi-drug-resistant bacteria hitch a ride with travellers; Anticholinergics sedatives and older people; Vitamin D: cause or effect?

**Pharmacy GuildChanges to the arrangements for medication management programs funded under the Community Pharmacy Agreementhttp://www.guild.org.au/docs/default-source/public-documents/news-and-events/media-releases/2014/mr_cpa-changes_12-feb2014.pdf?sfvrsn=2

**TGAAusPARs added: Mirabegron (Betmiga), Pneumococcal polysaccharide conjugate vaccine (Prevenar 13) and Regorafenib (Stivarga)http://www.tga.gov.au/industry/pm-auspar.htm

REPORTS AND PUBLICATIONS - INTERNATIONAL**FDA- FDA expands the approved use of Imbruvica (ibrutinib) for chronic lymphocytic leukemia (CLL) patients who have received at least one previous therapy.http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm385764.htm- Northera capsules (droxidopa) approved for the treatment of neurogenic orthostatic hypotension (NOH)http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm386311.htm- FDA approves Vimizim (elosulfase alfa), the first FDA-approved treatment for Mucopolysaccharidosis Type IVA (Morquio A syndrome)http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm386008.htm

**NHS Evidence- Eyes on Evidence February 2014. Includes: Iodine deficiency in pregnancy; Silicone cervical pessaries in women with a multiple pregnancy; Prenatal valproate exposure and autism in children http://www.evidence.nhs.uk/eyes-on-evidence-february-2014.pdf- Evidence Update January 2014: Prevention of cardiovascular disease-A summary of selected new evidence relevant to NICE public health guidance 25 ‘Prevention of cardiovascular disease’ (2010)www. evidence .nhs.uk/ evidence - update -50 - Evidence Update February 2014: The epilepsies - A summary of selected new evidence relevant to NICE clinical guideline 137 ‘The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care’(2012)www. evidence .nhs.uk/ evidence - update -53

MEDICATION SAFETY**HQSCNZMedication Safety Watch February 2014Key messages in this issue: Off-label use of medicines; Transdermal patches alerts; US medication safety best practices; Incidents and cautionshttp://www.hqsc.govt.nz/assets/Medication-Safety/Watch-Updates/Medication-Safety-Watch-9-Feb-2014.pdf

**ISMP- 2014-2015 Targeted Medication Safety Best Practices for Hospitalshttp://www.ismp.org/tools/bestpractices/TMSBP-for-Hospitals.pdf- NAN Alert: Potential inaccuracy of electronically transmitted medication history information used for medication reconciliationhttp://www.ismp.org/NAN/files/NAN-20140218.pdf- Acute Care Newsletter: How FDA can help reduce dabigatran (PRADAXA) bleeding risks

http://www.ismp.org/Newsletters/acutecare/showarticle.aspx?id=71

**MHRADrug Safety Update February 2014. Includes: Cetuximab: importance of establishing wild type RAS (KRAS and NRAS) status before treatment of metastatic colorectal cancer; Combined hormonal contraceptives and venous thromboembolism: review confirms risk is small—consider risk factors and remain vigilant for signs and symptomshttp://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/

PAPERS OF INTEREST**Am J Health Syst PharmAdditives to local anesthetics for peripheral nerve blocks: Evidence, limitations, and recommendationshttp://www.ajhp.org/content/71/5/373.abstract

**Ann Intern MedTreatment of Primary Sjögren Syndrome With Rituximab: A Randomized Trialhttp://annals.org/article.aspx?articleid=1829791

**Aust PresIntravenous paracetamol in paediatrics: cause for caution (M. Gazarian, A. Drew, A. Bennett)http://www.australianprescriber.com/magazine/37/1/24/5

**BMJ Qual SafFrom physician intent to the pharmacy label: prevalence and description of discrepancies from a cross-sectional evaluation of electronic prescriptionshttp://qualitysafety.bmj.com/content/23/3/223.short?g=w_qs_current_tab

**JAMA- Effect of Citalopram on Agitation in Alzheimer Disease: The CitAD Randomized Clinical Trialhttp://jama.jamanetwork.com/article.aspx?articleid=1829989 - Treatment of Venous Thromboembolismhttp://jama.jamanetwork.com/article.aspx?articleid=1829996 - New Oral Anticoagulants for Acute Venous Thromboembolismhttp://jama.jamanetwork.com/article.aspx?articleid=1829983

**JAMA Intern Med- Dronedarone for Atrial Fibrillation: The Limited Reliability of Clinical Practice Guidelineshttp://archinte.jamanetwork.com/article.aspx?articleid=1830022- Histamine-2 Receptor Antagonists vs Proton Pump Inhibitors on Gastrointestinal Tract Hemorrhage and Infectious Complications in the Intensive Care Unithttp://archinte.jamanetwork.com/article.aspx?articleid=1830021

- Multifaceted Intervention to Improve Medication Adherence and Secondary Prevention Measures After Acute Coronary Syndrome Hospital Discharge: A Randomized Clinical Trialhttp://archinte.jamanetwork.com/article.aspx?articleid=1779681- Assessing Potential Glycemic Overtreatment in Persons at Hypoglycemic Riskhttp://archinte.jamanetwork.com/article.aspx?articleid=1785199

**JAMIA- A sense inventory for clinical abbreviations and acronyms created using clinical notes and medical dictionary resourceshttp://jamia.bmj.com/content/21/2/299.abstract - Mining clinical text for signals of adverse drug-drug interactions http://jamia.bmj.com/content/21/2/353.abstract - Sensitivity and specificity of dosing alerts for dosing errors among hospitalized pediatric patientshttp://jamia.bmj.com/content/early/2014/02/04/amiajnl-2013-002161.abstract - Evaluation of medium-term consequences of implementing commercial computerized physician order entry and clinical decision support prescribing systems in two ‘early adopter’ hospitalshttp://jamia.bmj.com/content/early/recent

** Lancet CardiolPrasugrel versus clopidogrel for patients with unstable angina or non-ST-segment elevation myocardial infarction with or without angiography: a secondary, prespecified analysis of the TRILOGY ACS trialhttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61451-8/fulltext

**NEJMComparison of Pregabalin with Pramipexole for Restless Legs Syndromehttp://www.nejm.org/doi/full/10.1056/NEJMoa1303646

**PediatricsDexamethasone for Acute Asthma Exacerbations in Children: A Meta-analysishttp://pediatrics.aappublications.org/content/early/2014/02/04/peds.2013-2273

TAG Mail 12th February 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**TGAOrphan drugs: added Olaparib

http://www.tga.gov.au/industry/pm-orphan-drugs.htm

REPORTS AND PUBLICATIONS - INTERNATIONAL**AHRQ PSNetMultifactorial Medication Mishap - Case of a 10-fold overdose of an opioid medication, includes commentary and key learning points.http://webmm.ahrq.gov/case.aspx?caseID=314

**BNF UpdateRecommended indications and doses of paracetamol in children have been revisedhttp://www.pharmpress.com/mailouts/bnf/feb14/BNF_enewsletter.html#section3

**Joint Commission- New Toolkit Aims to Decrease Central Line-Associated Bloodstream Infectionshttps://www.jointcommission.org/new_toolkit_aims_to_decrease_central_line_associated_bloodstream_infections/ - Free guides help leaders and physicians develop patient safety strategies and improve bedside carehttp://www.jointcommission.org/issues/article.aspx?Article=buNJYCJ7IK7Xd%2buc0vde7AwcfSmpYQ72Jx4HoCapJ7g%3d

**NICE- Evidence summary new medicines: -- ESNM33 Chronic obstructive pulmonary disease: indacaterol/glycopyrronium (Ultibro Breezhaler)http://www.nice.org.uk/mpc/evidencesummariesnewmedicines/ESNM33.jsp- Evidence summary unlicensed/off-label medicine:-- ESUOM25 Non-cystic fibrosis bronchiectasis: colistimethate sodiumhttp://www.nice.org.uk/mpc/evidencesummariesunlicensedofflabelmedicines/ESUOM25.jsp- Clinical Guidelines:-- CG177 Osteoarthritis: care and management in adultshttp://guidance.nice.org.uk/CG177-- CG178 Psychosis and schizophrenia in adults: treatment and managementhttp://guidance.nice.org.uk/CG178- Quality Standards-- QS53 Anxiety Disordershttp://guidance.nice.org.uk/QS53

**SIGNSIGN Guideline 137: Management of lung cancerhttp://www.sign.ac.uk/guidelines/fulltext/137/index.html

MEDICATION SAFETY**TGASafety Advisory: Strontium ranelate (Protos) and risk of adverse eventshttp://www.tga.gov.au/safety/alerts-medicine-strontium-ranelate-protos-140204.htm

**FDAFDA Drug Safety Communication: FDA to review heart failure risk with diabetes drug saxagliptinhttp://www.fda.gov/Drugs/DrugSafety/ucm385287.htm

**MHRADrug Safety Update January 2014. Includes: Prasugrel (Efient): increased risk of bleeding—information on timing of loading dose; Ofatumumab: screen for hepatitis B virus before treatment; Temozolomide: risk of hepatic injury, including fatal hepatic failure—updated warnings and monitoring guidance; Capecitabine: risk of severe skin reactions—discontinue treatment.http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/index.htm

**Health CanadaLithium – Risk of hypercalcemia and hyperparathyroidismhttp://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/37903a-eng.php

PAPERS OF INTEREST**Br J PsychInterventions for reducing benzodiazepine use in older people: meta-analysis of randomised controlled trialshttp://bjp.rcpsych.org/content/204/2/98.abstract

**Can Pharm JA practice tool for the new oral anticoagulantshttp://cph.sagepub.com/content/147/1/25.full.pdf+html

**Clin Inf DisDALI: Defining Antibiotic Levels in Intensive care unit patients: Are current beta-lactam antibiotic doses sufficient for critically ill patients?http://cid.oxfordjournals.org/content/early/2014/01/14/cid.ciu027

**Ann Intern MedEffectiveness of Combination Therapy With Statin and Another Lipid-Modifying Agent Compared With Intensified Statin Monotherapy: A Systematic Reviewhttp://annals.org/article.aspx?articleid=1828554

**BMJRates and risk factors for prolonged opioid use after major surgery: population based cohort study

http://www.bmj.com/content/348/bmj.g1251

**Cochrane Library- Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependencehttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD002207.pub4/abstract;jsessionid=E1DE03DFFA3219521AA5ECA28AE7D00B.f01t02 - Mycophenolate mofetil for relapsing-remitting multiple sclerosishttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010242.pub2/abstract - Pharmacological interventions for hypertension in childrenhttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008117.pub2/abstract

**Eur J Hosp PharmPharmacist contributions to ensuring safe and accurate transfer of written medicines-related discharge information: lessons from a collaborative audit and service evaluation involving 45 hospitals in Englandhttp://ejhp.bmj.com/content/early/2014/02/10/ejhpharm-2013-000418?papetoc

**Eur Heart JCost-effectiveness of apixaban vs. current standard of care for stroke prevention in patients with atrial fibrillationhttp://eurheartj.oxfordjournals.org/content/early/2014/02/07/eurheartj.ehu006.abstract

**JAMA Intern MedNudging Guideline-Concordant Antibiotic Prescribing: A Randomized Clinical Trialhttp://archinte.jamanetwork.com/article.aspx?articleid=1815102

**Jt Comm J Qual Pat SafAssessing the State of Safe Medication Practices Using the ISMP Medication Safety Self Assessment® for Hospitals: 2000 and 2011http://www.ingentaconnect.com/content/jcaho/jcjqs/2014/00000040/00000002/art00001

**Lancet Diabetes EndocrinolMetformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trialhttp://download.thelancet.com/pdfs/journals/landia/PIIS2213858713701529.pdf

**Lancet OncSecond primary malignancies with lenalidomide therapy for newly diagnosed myeloma: a meta-analysis of individual patient datahttp://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(13)70609-

0/abstract

TAG Mail 5th February 2014

REPORTS AND PUBLICATIONS – AUSTRALIA**ACSQHCEvaluating the Effect of the Australian List of Tall Man Nameshttp://www.safetyandquality.gov.au/wp-content/uploads/2014/01/Evaluating-the-Effect-of-the-Australian-List-of-Tall-Man-Names.pdf **Productivity Commission- Report on Government Services 2014, Volume E: Healthhttp://www.pc.gov.au/gsp/rogs/health

**TGA- Pilot web service for transmission of adverse event reports from medical software to the Therapeutic Goods Administrationhttp://www.tga.gov.au/newsroom/media-2014-pilot-web-servce-140203.htm- AusPARs: Added nanoparticle albumin-bound (nab) paclitaxel (Abraxane)http://www.tga.gov.au/industry/pm-auspar.htm

REPORTS AND PUBLICATIONS - INTERNATIONAL**AHRQ- Factors That Influence the Scale Up and Spread of Innovations http://www.innovations.ahrq.gov/content.aspx?id=4088&utm_source=issueanc&utm_medium=email&utm_campaign=20140129- Statewide Measurement and Reporting System Stimulates Quality Improvement in Targeted Clinical Areashttp://www.innovations.ahrq.gov/content.aspx?id=3914

**CADTH- Flushing Intravenous Tubing Post Administration of Medications: Clinical Evidence and Guidelineshttp://www.cadth.ca/media/pdf/htis/feb-2014/RA0657%20Flushing%20IV%20Lines%20Final.pdf- Buprenorphine/Naloxone (Suboxone) Film versus Buprenorphine/Naloxone Tablets for the Treatment of Opioid Addiction: Comparative Safetyhttp://www.cadth.ca/media/pdf/htis/feb-2014/RB0642%20Suboxone%20Final.pdf- Intranasal Versus Intravenous Administration of Anxiolytic or Analgesic Medications: Comparative Clinical Effectiveness

http://www.cadth.ca/media/pdf/htis/feb-2014/RB0641%20Intranasal%20Administration%20Final.pdf- Smart Infusion Pump use in Hospitalized Patients: Clinical Safety and Guidelineshttp://www.cadth.ca/media/pdf/htis/feb-2014/RB0640%20Smart%20Pumps%20Final.pdf

**EMAReview of Emergency Contraceptives started: The European Medicines Agency has started a review of emergency contraceptives to assess whether increased bodyweight and body mass index (BMI) reduce the efficacy of these medicines in preventing an unintended pregnancy following unprotected sexual intercourse or contraceptive failure.http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2014/01/news_detail_002010.jsp&mid=WC0b01ac058004d5c1

**FDA- FDA approves Hetlioz (tasimelteon), a melatonin receptor agonist, the first treatment for non-24 hour sleep-wake disorder in blind individuals http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm384092.htm

**NICE- Evidence summary new medicines: -- ESNM31 Long-acting reversible contraception: subcutaneous depot medroxyprogesterone acetate (DMPA-SC)http://www.nice.org.uk/mpc/evidencesummariesnewmedicines/ESNM31.jsp-- ESNM32 Relapsed and refractory multiple myeloma: pomalidomidehttp://www.nice.org.uk/mpc/evidencesummariesnewmedicines/ESNM32.jsp-Quality Standards:-- QS52 Peripheral arterial disease http://guidance.nice.org.uk/QS52-Clinical Guidelines:-- CG175 Prostate cancer: diagnosis and treatmenthttp://guidance.nice.org.uk/CG175-- CG176 Head Injury: Triage, assessment, investigation and early management of head injury in children, young people and adultshttp://guidance.nice.org.uk/CG176-Technology Appraisal -- TA303 Teriflunomide for treating relapsing-remitting multiple sclerosishttp://guidance.nice.org.uk/TA303

**NHS England- National Patient Safety Alerting System (NPSAS) launched - a tool that will be used to ensure warnings of potential risks to the safety of patients can be swiftly developed and disseminated across the NHS.http://www.england.nhs.uk/2014/01/31/mike-durkin-4/- Principles for sharing the benefits associated with more efficient use of medicines not reimbursed through national prices

http://www.england.nhs.uk/wp-content/uploads/2014/01/princ-shar-benefits.pdf

MEDICATION SAFETY**TGA- Medicines Safety Update, February 2014. In this issue: Quetiapine and QT prolongation; bioCSL Fluvax - not for children under 5 years; How you can play a vital role in medicine regulation.http://www.tga.gov.au/hp/msu-2014-01.htm- Hazard Alert: Medtronic SynchroMed II implantable infusion pump system: risk of incorrect pump replacement scheduling and premature reservoir alarmshttp://www.tga.gov.au/safety/alerts-device-medtronic-synchromed-II-140204.htm

**FDA- Testosterone Products: Drug Safety Communication - FDA Investigating Risk of Cardiovascular Eventshttp://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm384225.htm

**Health CanadaHealth Canada evaluating whether body weight affects the effectiveness of emergency contraceptive pillhttp://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/37771a-eng.php

**ISMP- A mislabeling event with batched drugs: The unintended consequences of practice changeshttp://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=68

PAPERS OF INTEREST**Am J Health Syst Pharm- Multidisciplinary initiative to improve inpatient anticoagulation and management of venous thromboembolismhttp://www.ajhp.org/content/71/4/305- Development of an electronic patient prioritization tool for clinical pharmacist interventionshttp://www.ajhp.org/cgi/content/abstract/71/4/311?etoc

**Ann Intern Med- Lipid Management in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2013 Clinical Practice Guidelinehttp://annals.org/article.aspx?articleid=1788220- Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Disease Risk in Adults: Synopsis of the 2013 ACC/AHA Cholesterol Guidelinehttp://annals.org/article.aspx?articleid=1818923

**Annals of PharmacotherapyMedication Reconciliation During Transitions of Care as a Patient Safety Strategyhttp://annals.org/article.aspx?articleid=1656444

**BMJ- Safety of benzodiazepines and opioids in very severe respiratory disease: national prospective studyhttp://www.bmj.com/content/348/bmj.g445 

**Eur J Hosp Pharm- No evidence or evidence of no effecthttp://ejhp.bmj.com/content/early/2014/01/30/ejhpharm-2014-000445.full

**Heart- Risk of drug-induced liver injury with the new oral anticoagulants: systematic review and meta-analysishttp://heart.bmj.com/content/early/2014/01/29/heartjnl-2013-305288.abstract- Maintenance of statin use over 3 years following acute coronary syndromes: a national data linkage study (ANZACS-QI-2)http://heart.bmj.com/content/early/2014/01/16/heartjnl-2013-304960.abstract

**JAMAEffects of Immediate Blood Pressure Reduction on Death and Major Disability in Patients With Acute Ischemic Stroke: The CATIS Randomized Clinical Trialhttp://jama.jamanetwork.com/article.aspx?articleid=1778674

**JAMA Intern MedMultifaceted Intervention to Improve Medication Adherence and Secondary Prevention Measures After Acute Coronary Syndrome Hospital Discharge: A Randomized Clinical Trialhttp://archinte.jamanetwork.com/article.aspx?articleid=1779681

**J Clin Oncol- Clinical Impact of Delaying Initiation of Adjuvant Chemotherapy in Patients with Breast Cancerhttp://jco.ascopubs.org/content/early/2014/01/21/JCO.2013.49.7693.abstract

**MJAOff-label prescribing (editorial, J P Seale)https://www.mja.com.au/journal/2014/200/2/label-prescribing

**Psychosomatics

- Use of Serotonergic Antidepressants and Bleeding Risk in Patients Undergoing Surgery.http://www.sciencedirect.com/science/article/pii/S0033318213001692

TAG Mail 29th January 2013

REPORTS AND PUBLICATIONS - AUSTRALIA**AIHW- Medical workforce 2012http://www.aihw.gov.au/publication-detail/?id=60129546100  

REPORTS AND PUBLICATIONS - INTERNATIONAL**Department of Health (USA)- Updated guidance on occupational HIV post-exposure prophylaxis (PEP) from the UK Chief Medical Officers' Expert Advisory Group on AIDS (EAGA)https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/275060/EAGA_advice_on_PEP_after_exposure_to_UD_source_Dec13.pdf  

**Health Canada- ARZERRA (ofatumumab) - Recommendations to Screen, Monitor and to Manage Hepatitis B Virus Reactivationhttp://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/37705a-eng.php  

**NHS- Combined hormonal contraceptives: Europe-wide review confirms the risk of thromboembolism is small and agrees updated information to reflect the latest evidencehttps://www.cas.dh.gov.uk/ViewandAcknowledgment/ViewAlert.aspx?AlertID=102106  

**NICE- Teriflunomide for treating relapsing-remitting multiple sclerosishttp://www.nice.org.uk/nicemedia/live/14353/66336/66336.pdf - Prevention of cardiovascular disease: Evidence Update January 2014http://arms.evidence.nhs.uk/resources/hub/1032130/attachment  

MEDICATION SAFETYNil

PAPERS OF INTEREST**Am J Surg- Weight-based enoxaparin dosing for venous thromboembolism prophylaxis in the obese trauma patient

http://www.americanjournalofsurgery.com/article/S0002-9610%2813%2900434-0/abstract  

**Ann Intern Med- Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Disease Risk in Adults: Synopsis of the 2013 ACC/AHA Cholesterol Guidelinehttp://annals.org/article.aspx?articleid=1818923  - Concepts and Controversies: The 2013 American College of Cardiology/American Heart Association Risk Assessment and Cholesterol Treatment Guidelineshttp://annals.org/article.aspx?articleid=1817256  

**Ann Rheum Dis- Extended report: Effects and safety of rituximab in systemic sclerosis: an analysis from the European Scleroderma Trial and Research (EUSTAR) grouphttp://ard.bmj.com/content/early/2014/01/17/annrheumdis-2013-204522.full.pdf+html  

**BJCP- Is polypharmacy always hazardous? A retrospective cohort analysis using linked electronic health records from primary and secondary carehttp://onlinelibrary.wiley.com/doi/10.1111/bcp.12292/abstract;jsessionid=744F9D96B7AB49FDD92B879266545F8C.f02t02  

**BMJ- Undetermined impact of patient decision support interventions on healthcare costs and savings: systematic reviewhttp://www.bmj.com/content/348/bmj.g188  

**BMJ Qual Saf- Using quality improvement to optimise paediatric discharge efficiencyhttp://qualitysafety.bmj.com/content/early/2014/01/27/bmjqs-2013-002556.abstract

**Circulation- Optimal Duration of Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation: A Randomized, Controlled Trialhttp://circ.ahajournals.org/content/129/3/304.abstract  -Warfarin Use and the Risk for Stroke and Bleeding in Patients with Atrial Fibrillation undergoing Dialysishttp://circ.ahajournals.org/content/early/2014/01/22/CIRCULATIONAHA.113.004777.abstract  - Antiplatelet Therapy for Stable Coronary Artery Disease in Atrial Fibrillation Patients on Oral Anticoagulant: A Nationwide Cohort Studyhttp://circ.ahajournals.org/content/early/2014/01/27/CIRCULATIONAHA.113.004834.abstract  

**Cochrane- Clonidine premedication for postoperative analgesia in childrenhttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009633.pub2/abstract  - Dihydroartemisinin-piperaquine for treating uncomplicated Plasmodium falciparum malariahttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010927/abstract  - Implementation of treatment guidelines for specialist mental health carehttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009780.pub2/abstract  

**Eur J Hosp Pharm- The tools of evidence-based medicinehttp://ejhp.bmj.com/content/early/2014/01/28/ejhpharm-2014-000442.extract  

**JAMA- Evidence-Based Medicine - An Oral Historyhttp://jama.jamanetwork.com/article.aspx?articleid=1817042 - Clinical Trial Evidence Supporting FDA Approval of Novel Therapeutic Agents, 2005-2012http://jama.jamanetwork.com/article.aspx?articleid=1817794   - Scientific and Regulatory Reasons for Delay and Denial of FDA Approval of Initial Applications for New Drugs, 2000-2012http://jama.jamanetwork.com/article.aspx?articleid=1817795  

**JAMA Intern Med- Nudging Guideline-Concordant Antibiotic Prescribing: A Randomized Clinical Trialhttp://archinte.jamanetwork.com/article.aspx?articleid=1815102  

**Lancet Diabetes and Endocrinology- The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysishttp://www.thelancet.com/journals/landia/article/PIIS2213-8587(13)70212-2/abstract  

**NEJM- Acute Osteomyelitis in Childrenhttp://www.nejm.org/doi/full/10.1056/NEJMra1213956

TAG Mail 22nd January 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**ACSQHC

- Evaluation of Standardised Medicine Syringe Labels in Interventional Cardiac Catheter and Radiology Laboratorieshttp://www.safetyandquality.gov.au/publications/evaluation-of-standardised-medicine-syringe-labels-in-interventional-cardiac-catheter-and-radiology-laboratories/- Labelling Recommendations Issues Registerhttp://www.safetyandquality.gov.au/publications/labelling-recommendations-issues-register/

**AIHW- Dental workforce 2012http://www.aihw.gov.au/publication-detail/?id=60129545961- AIHW deaths snapshothttp://www.aihw.gov.au/deaths/

**NPSTreating neuropathic pain with anticonvulsants — which ones work?http://www.nps.org.au/health-professionals/health-news-evidence/latest-issue/treating-neuropathic-pain

**TGAAusPARS added: Alogliptin as benzoate (Vipidia/Nesina)http://www.tga.gov.au/industry/pm-auspar.htm

REPORTS AND PUBLICATIONS - INTERNATIONAL**CochraneSummaries:- Optimum duration of regimens for Helicobacter pylori eradicationhttp://summaries.cochrane.org/CD008337/ideal-length-of-treatment-for-helicobacter-pylori-h.-pylori-eradication- Statins for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis http://summaries.cochrane.org/CD008623/statins-for-non-alcoholic-steatohepatitis

**Health CanadaEFFIENT (prasugrel hydrochloride) - Association with Increased Risk of Bleeding in Patients Treated in Hospital for Certain Types of Heart Attacks - For Health Professionalshttp://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/37611a-eng.php

**NHSA report of NHS Services, Seven Days a Week Forum that sets out set out ten new clinical standards that describe the standard of urgent and emergency care all patients should expect seven days a week, each supported by clinical evidence and developed in partnership with the Academy of Medical Royal Collegeshttp://www.england.nhs.uk/2013/12/15/sir-bruce-keogh-7ds/

**NICEMedicines Evidence Commentary:Chronic kidney disease: calcium-based versus non-calcium-based phosphate binders https://www.evidence.nhs.uk/document?ci=http%3A%2F%2Farms.evidence.nhs.uk%2Fresources%2FHub%2F1032210&q=medicines%20evidence%20commentary&ReturnUrl=%2Fsearch%3Fq%3Dmedicines%2Bevidence%2Bcommentary

**SIGN- Managing chronic pain (patient booklet)http://www.sign.ac.uk/patients/publications/136/index.html- Prevention of stroke in patients with atrial fibrillation: A guide for primary care. http://www.sign.ac.uk/pdf/AF_publication.pdf

**The Health Foundation, LondonUsing clinical communities to improve quality: Ten lessons for getting the clinical community approach to work in practicehttp://www.health.org.uk/publications/using-clinical-communities-to-improve-quality/

MEDICATION SAFETY**MHRASafety warnings and messages for medicines, December 2013 included:Avoiding ponatinib in people with a history of myocardial infarction or stroke | minimising prasugrel bleeding risk | temozolomide and hepatic failure | capecitabine and severe skin reactions | screening for hepatitis B virus infection before starting ofatumumab http://www.mhra.gov.uk/Safetyinformation/Safetywarningsalertsandrecalls/Safetywarningsandmessagesformedicines/CON364176

PAPERS OF INTEREST**Am J Health-Syst- Pharm- Effect of barcode technology with electronic medication administration record on medication accuracy rateshttp://www.ajhp.org/content/71/3/209.abstract- Alternative dosing strategies for liraglutide in patients with type 2 diabetes mellitushttp://www.ajhp.org/content/71/3/223.abstract

**BMJ- Prenatal exposure to antidepressants and persistent pulmonary hypertension of the newborn: systematic review and meta-analysishttp://www.bmj.com/content/348/bmj.f6932.pdf%2Bhtml- A unified model of patient safety (or "Who froze my cheese?")http://www.bmj.com/content/347/bmj.f7273.pdf%2Bhtml

**Eur J Hosp Pharm

- Impact of electronic prescription alerts on medication errors related to vitamin K antagonists in hospitalised patientshttp://ejhp.bmj.com/content/21/1/29.short?g=w_ejhp_current_tab- Management of patients with HIV-1 infection by pharmacist prescribers: an evaluation of practicehttp://ejhp.bmj.com/content/21/1/13.short?g=w_ejhp_current_tab

**JAMAEffects of Immediate Blood Pressure Reduction on Death and Major Disability in Patients With Acute Ischemic Stroke: The CATIS Randomized Clinical Trialhttp://jama.jamanetwork.com/article.aspx?articleid=1778674

**Joint Commission Journal on Quality and Patient SafetyMedication event huddles: a tool for reducing adverse drug eventshttp://www.ingentaconnect.com/content/jcaho/jcjqs/2014/00000040/00000001/art00005

TAG Mail 15th January 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**ACSQHC- NIMC VTE Phase 2 Final Reporthttp://www.safetyandquality.gov.au/publications/nimc-vte-phase-2-final-report-pdf-1-63mb/- NIMC 2012 National Audit Reporthttp://www.safetyandquality.gov.au/publications/nimc-2012-national-audit-report-pdf-2-10kb/ - NIMC 2011 National Audit Reporthttp://www.safetyandquality.gov.au/publications/nimc-2011-national-audit-report-pdf-1-02mb/ - NIMC 2010 National Audit Reporthttp://www.safetyandquality.gov.au/publications/nimc-2010-national-audit-report-pdf-1-09mb/ - NIMC 2009 National Audit Reporthttp://www.safetyandquality.gov.au/publications/nimc-2009-national-audit-report-pdf-1-02mb/ - Electronic Medication Management Systems: Specialist Functionshttp://www.safetyandquality.gov.au/publications/electronic-medication-management-systems-specialist-functions-pdf-856kb/ - NIMC Local Management Guidelineshttp://www.safetyandquality.gov.au/publications/nimc-local-management-guidelines-pdf-133kb/ - NIMC and Psychiatric Acute Services Survey Report

http://www.safetyandquality.gov.au/publications/nimc-and-psychiatric-acute-services-survey-report-pdf-780-kb/ - Antimicrobial Stewardship in small health service organisationshttp://www.safetyandquality.gov.au/publications/antimicrobial-stewardship-in-small-health-service-organisations/ - Cessation of flexible transition arrangements for the NSQHS Standardshttp://www.safetyandquality.gov.au/publications/advisory-a1308-cessation-of-flexible-transition-arrangements-for-2013/

**AIHW- Australian hospital statistics 2012-13: Staphylococcus aureus bacteraemia in Australian public hospitals (released 20 December 2014)http://www.aihw.gov.au/publication-detail/?id=60129545754 - Specialist homelessness services 2012-13http://www.aihw.gov.au/publication-detail/?id=60129545629

**CINSWCancer Institute NSW Annual Report 2013http://www.cancerinstitute.org.au/publications/i/annual-report-2012-13

**NHMRCSummary Guide for the Management of Overweight and Obesity in Primary Carehttp://www.nhmrc.gov.au/guidelines/publications/n57?utm_medium=email&utm_campaign=NHMRC%20Health%20Tracker%20-%20December%202013&utm_content=NHMRC%20Health%20Tracker%20-%20December%202013+CID_d38b0d2f8edef604468c8a16e8bf95a2&utm_source=Mailbuild&utm_term=NHMRC%20website

**NPS- PPIs in older people — do you know the risks?http://www.nps.org.au/health-professionals/health-news-evidence/2014/ppi-risks-in-older-people - NPS Direct December 2013 includes:Vaccinate: take a shot at antibiotic resistance | Fast five: 2013 highlightshttp://www.nps.org.au/publications/health-professional/nps-direct/2013/november2

**NSW Health- Information Bulletin: Pharmaceutical Charges for Hospital Outpatients and Safety Net Thresholds 2014http://www0.health.nsw.gov.au/policies/ib/2013/IB2013_066.html - Policy Directive: Infants and Children: Acute Management of Abdominal Pain [PD2013_053]http://www0.health.nsw.gov.au/policies/pd/2013/PD2013_053.html

**TGA

- AusPARS added: Dabrafenib mesilate (Tafinlar) and Palonosetron hydrochloride (Aloxi)http://www.tga.gov.au/industry/pm-auspar.htm - Dextropropoxyphene - questions and answershttp://www.tga.gov.au/safety/alerts-medicine-dextropropoxyphene-qa.htm

REPORTS AND PUBLICATIONS - INTERNATIONAL**AHRQCommunication and Dissemination Strategies to Facilitate the Use of Health-Related Evidencehttp://www.ahrq.gov/research/findings/evidence-based-reports/commstrattp.html

**eMC- Aggrastat™ (tirofiban) SPC (PI equiv) revised to extend indications to include patients with STEMIhttp://www.medicines.org.uk/emc/medicine/2478/SPC/Aggrastat%20250%20mcg%20ml%20Concentrate%20for%20Solution%20for%20Infusion/ - Crixivan (indinavir) 200 mg and 400 mg hard capsules SPC updated to advise that quetiapine should not be co-administered with indinavirhttp://www.medicines.org.uk/emc/medicine/14292/SPC/CRIXIVAN%20200%20mg%20and%20400%20mg%20hard%20capsules/ - Revised SPC: Xarelto (rivaroxaban) 10mg, 15mg and 20mg film-coated tablets SPC revised to include angioedema and allergic oedema as undesirable effects reported during post-marketing experience http://www.medicines.org.uk/emc/medicine/21265/SPC/Xarelto%2010%20mg%20film-coated%20tablets/

**EMA- Abraxane® (paclitaxel formulated as albumin bound nanoparticles) approved in EU (in combination with gemcitabine) for first-line treatment of adults with metastatic adenocarcinoma of the pancreas. The approval was based on results of the MPACT Phase III trialhttp://www.businesswire.com/portal/site/biospace/template.PAGE/menuitem.ab520ce17e34ab71ff00d635c0908a0c/index.jsp?ndmViewId=news_view&newsId=20140107005842&newsLang=en- European Medicines Agency recommends approval of a new medicine, Sirturo (bedaquiline), for multidrug-resistant tuberculosishttp://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2013/12/news_detail_001999.jsp&mid=WC0b01ac058004d5c1 - Acipimox only to be used as additional or alternative treatment to reduce high triglyceride levelshttp://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2013/12/news_detail_002000.jsp&mid=WC0b01ac058004d5c1

**FDARivaroxaban labelling revision

http://www.accessdata.fda.gov/drugsatfda_docs/appletter/2014/022406Orig1s007ltr.pdf

**NICE- Evidence Summary: new medicine-- ESNM30 Prostate cancer: triptorelin (Decapeptyl SR)http://www.nice.org.uk/mpc/evidencesummariesnewmedicines/ESNM30.jsp -- ESNM28: Combined oral contraception: nomegestrol/estradiol (Zoely)http://publications.nice.org.uk/combined-oral-contraception-nomegestrolestradiol-zoely-esnm28 - Evidence Summary: unlicensed or off-label medicine-- ESUOM24: Critical limb ischaemia in peripheral vascular disease: intravenous iloprosthttp://publications.nice.org.uk/critical-limb-ischaemia-in-peripheral-vascular-disease-intravenous-iloprost-esuom24 -- ESUOM23 Transient ischaemic attack: clopidogrelhttp://www.nice.org.uk/mpc/evidencesummariesunlicensedofflabelmedicines/ESUOM23.jsp - Evidence Update:-- Post-traumatic stress disorder (PTSD)http://www.evidence.nhs.uk/document?ci=http%3A%2F%2Farms.evidence.nhs.uk%2Fresources%2FHub%2F1031525&q=evidence%20update

MEDICATION SAFETY**EMAPRAC recommends suspending use of Protelos/Osseor (strontium ranelate)http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2014/01/news_detail_002005.jsp&mid=WC0b01ac058004d5c1

**FDASodium Phosphate Over-the-Counter Products: Drug Safety Communication - Possible Harm From Exceeding Recommended Dosehttp://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm380833.htm

**Health Canada- Jevtana (cabazitaxel) - Potential for Medication Errors During Preparation Leading to Overdose: pharmacy staff should add the ENTIRE content of the diluent vial to the concentrate. Reconstitution errors that led to overdoses 15% to 20% higher than the prescribed dose reported in Europehttp://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/37453a-eng.php - MedEffect safety information notice: Sublinox (zolpidem tartrate) - New Dosage Recommendations to Minimize Risk of Next-Day Impairment in Both Women and Men. The recommended initial dose has been lowered to 5 mg for women and either 5 or 10 mg for men, taken only once per night immediately before bedtime with at least 7-8 hours remaining before awakening.

http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/37415a-eng.php

**NICE- Eyes on Evidence, January 2014 includes:-- Antibiotics and community-associated Clostridium difficile infectionhttps://www.evidence.nhs.uk/eyes-on-evidence-january-2014.pdf

PAPERS OF INTEREST**Am J Health-Syst Pharm- Comparison of medication safety effectiveness among nine critical access hospitalshttp://www.ajhp.org/content/70/24/2218.abstract?etoc - Standardized versus custom parenteral nutrition: Impact on clinical and cost-related outcomes http://www.ajhp.org/cgi/content/abstract/71/2/114 - Outcomes of a new dosage regimen of amikacin based on pharmacokinetic parameters of Korean neonates http://www.ajhp.org/cgi/content/abstract/71/2/122

**Am J MedMyocardial ischemic events in ‘real world’ patients with atrial fibrillation treated with dabigatran or warfarin: A nationwide cohort studyhttp://www.amjmed.com/article/S0002-9343(13)01073-5/abstract

**Am J PsychiatryDrug-Induced Long QT in Adult Psychiatric Inpatients: The 5-Year Cross-Sectional ECG Screening Outcome in Psychiatry Studyhttp://ajp.psychiatryonline.org/article.aspx?articleID=1787323

**Ann Intern MedHealth Information Technology: An Updated Systematic Review with a Focus on Meaningful Usehttp://annals.org/article.aspx?articleID=1811028

**BMC Medical Research MethodologySearch strategies to identify reports on “off-label” drug use in EMBASEhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543848/pdf/1471-2288-12-190.pdf

**BMJ Qual SafGoverning patient safety: lessons learned from a mixed methods evaluation of implementing a ward-level medication safety scorecard in two English NHS hospitalshttp://qualitysafety.bmj.com/content/23/2/136?etoc

**Cochrane

- Inotropic agents and vasodilator strategies for acute myocardial infarction complicated by cardiogenic shock or low cardiac output syndromehttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009669.pub2/abstract - Trifluoperazine versus placebo for schizophreniahttp://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010226.pub2/abstract

**Eur Heart JPeri-interventional management of novel oral anticoagulants in daily care: results from the prospective Dresden NOAC registryhttp://eurheartj.oxfordjournals.org/content/early/2014/01/05/eurheartj.eht557.full.pdf?papetoc

**JAMAPharmacological Treatments for Smoking Cessationhttp://jama.jamanetwork.com/article.aspx?articleid=1812940

**JAMA NeurologyNew Oral Anticoagulants and the Risk of Intracranial Hemorrhage: Traditional and Bayesian Meta-analysis and Mixed Treatment Comparison of Randomized Trials of New Oral Anticoagulants in Atrial Fibrillationhttp://archneur.jamanetwork.com/article.aspx?articleid=1788609

**New Engl J MedA Randomized Trial of Hyperglycemic Control in Pediatric Intensive Carehttp://www.nejm.org/doi/pdf/10.1056/NEJMoa1302564

**PaediatricsRecognition and Management of Iatrogenically Induced Opioid Dependence and Withdrawal in Childrenhttp://pediatrics.aappublications.org/content/133/1/152.abstract

TAG Mail 7th January 2014

REPORTS AND PUBLICATIONS - AUSTRALIA**AIHWAustralia's mothers and babies 2011http://www.aihw.gov.au/publication-detail/?id=60129545702

**NMTAN (National Medical Training Advisory Network)Health Information Workforce Report (October 2013)http://www.hwa.gov.au/sites/uploads/HWA13IAP009_Health-Information-Workforce-Report_v3.pdf

REPORTS AND PUBLICATIONS - INTERNATIONAL**MedEffect CanadaRevlimid (lenalidomide) - Risk of Liver Problems - For Health Professionalshttp://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2013/37383a-eng.php

**NICE- Non-cystic fibrosis bronchiectasis: colistimethate sodium

http://www.nice.org.uk/mpc/evidencesummariesunlicensedofflabelmedicines/ESUOM25.jsp

- Evidence summary for a new medicine: ESNM29 Alcohol dependence: nalmefene

http://www.nice.org.uk/mpc/evidencesummariesnewmedicines/ESNM29.jsp

MEDICATION SAFETY**eMCRevised SPC: Pioglitazone 15/30/45mg tablets (Sandoz generic): Postmarketing reports of hypersensitivity reactions in patients treated with pioglitazone have been reported. These reactions include anaphylaxis, angioedema, and urticaria and have been added to section 4.8http://www.medicines.org.uk/emc/medicine/26001/SPC/Pioglitazone%2015mg%20Tablets

**FDADrug Safety Communication: Methylphenidate ADHD Medications - Risk of Long-lasting Erectionshttp://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm378876.htm

**New Zealand Health Quality and Safety Commission- New alert gives advice on the management of transdermal patches

http://www.hqsc.govt.nz/news-and-events/news/1304/- The New Zealand Tall Man lettering list is now availablehttp://www.hqsc.govt.nz/our-programmes/medication-safety/projects/tall-man-lettering/

PAPERS OF INTEREST**Am J Health Sys PharmRisk of hepatotoxicity associated with fluoroquinolones: A national case–control safety study http://www.ajhp.org/cgi/content/abstract/71/1/37

**Am J Perinatol.Medication Use in the Neonatal Intensive Care Unithttps://www.thieme-connect.de/ejournals/abstract/10.1055/s-0033-1361933

**Arch Gerontol Geriatr

An inter-rater reliability study of the prescribing indicated medications quality indicators of the ACOVE 3 criteria as a potentially inappropriate prescribing toolhttp://www.sciencedirect.com/science/article/pii/S0167494313001982

**BoneUpdate on long-term treatment with bisphosphonates for postmenopausal osteoporosis: A systematic reviewhttp://www.sciencedirect.com/science/article/pii/S8756328213003785

**BMJ Quality and SafetyBatalden P. Making Improvement Interventions Happen — The Work Before the Work: Four Leaders Speakhttp://qualitysafety.bmj.com/content/early/2013/09/19/bmjqs-2013-002440

**ChestRisk of serious atrial fibrillation and stroke with use of bisphosphonates: evidence from a meta-analysishttp://journal.publications.chestnet.org/article.aspx?articleid=1691936

**Eur Heart JInitiation of warfarin in patients with atrial fibrillation: early effects on ischaemic strokeshttp://eurheartj.oxfordjournals.org/content/early/2013/12/15/eurheartj.eht499.abstract

**JAMA- 2014 Evidence-Based Guideline for the Management of High Blood

Pressure in Adultshttp://jama.jamanetwork.com/article.aspx?articleid=1791497- Effect of Vitamin E and Memantine on Functional Decline in Alzheimer

Diseasehttp://jama.jamanetwork.com/article.aspx?articleid=1810379

**JAMA Intern Med- Lower Risk of Cardiovascular Events in Postmenopausal Women Taking

Oral Estradiol Compared With Oral Conjugated Equine Estrogenshttp://archinte.jamanetwork.com/article.aspx?articleid=1741892- Gabapentin Treatment for Alcohol Dependence: A Randomized Clinical

Trialhttp://archinte.jamanetwork.com/article.aspx?articleid=1764009- Renoprotective Effect of Renin-Angiotensin-Aldosterone System

Blockade in Patients With Predialysis Advanced Chronic Kidney Disease, Hypertension, and Anemia

http://archinte.jamanetwork.com/article.aspx?articleid=1787693

**Journal of Patient Safety- Safe Use of Electronic Health Records and Health Information Technology Systems: Trust But Verify

http://journals.lww.com/journalpatientsafety/Fulltext/2013/12000/Safe_Use_of_Electronic_Health_Records_and_Health.1.aspx- Automated Adverse Event Detection Collaborative: Electronic Adverse Event Identification, Classification, and Corrective Actions Across Academic Pediatric Institutionshttp://journals.lww.com/journalpatientsafety/Abstract/2013/12000/Automated_Adverse_Event_Detection_Collaborative__.4.aspx

**New Engl J MedVaccine for Prevention of Mild and Moderate-to-Severe Influenza in Children http://www.nejm.org/doi/full/10.1056/NEJMoa1215817?query=TOC

**PaediatricsComparative Effectiveness of Empiric Antibiotics for Community-Acquired Pneumoniahttp://pediatrics.aappublications.org/content/133/1/e23.abstract