MicroRNA expression in polarized macrophages

Table S3. Changes in miRNA expression in polarized MDMs relative to untreated controls. miRNA identity and assay # No

Treatment M1 M2a M2b M2c Mean Fold Change

D1 D2 D3 D1 D2 D3 D1 D2 D3 D1 D2 D3 D1 D2 D3 M1 M2a M2b M2c

hsa-let-7a*-4395418 1 1 1 0.81 0.791 0.603 0.584 1.155 1.045 0.884 1.117 1.152 1.687 0.825 0.408 0.735 0.928 1.051 0.973

hsa-let-7a-4373169 1 1 1 0.937 1.095 1.139 0.948 1.001 1.18 0.874 0.927 0.974 0.973 0.838 1.289 1.057 1.043 0.925 1.033

hsa-let-7b-4395446 1 1 1 1.656 0.704 0.442 0.729 0.735 0.846 1.219 0.69 0.669 1.299 0.698 0.875 0.934 0.770 0.859 0.957

hsa-let-7c-4373167 1 1 1 0.706 0.932 0.834 0.681 1.169 0.805 0.699 0.821 0.778 0.684 1.007 0.752 0.824 0.885 0.766 0.814

hsa-let-7d-4395394 1 1 1 0.845 0.818 1.167 0.861 0.889 1.079 1.001 0.883 0.878 0.953 0.863 1.538 0.943 0.943 0.921 1.118

hsa-let-7e*-4395518 1 1 1 3.176 0.673 3.042 0.776 0.711 2.621 1.284 0.388 2.84 1.93 0.566 0.719 2.297 1.369 1.504 1.072

hsa-let-7e-4395517 1 1 1 0.928 0.763 1.138 1.04 0.675 0.933 0.861 0.785 0.859 1.035 0.743 1.16 0.943 0.883 0.835 0.979

hsa-let-7f-4373164 1 1 1 0.672 0.625 0.968 0.885 0.625 0.743 0.922 0.651 0.598 0.708 0.605 0.885 0.755 0.751 0.724 0.733

hsa-let-7g*-4395229 1 1 1 0.87 0.715 0.847 0.909 0.6 1.032 0.939 0.567 0.907 0.998 0.286 0.7 0.811 0.847 0.804 0.661

hsa-let-7g-4395393 1 1 1 1.307 1.029 1.228 1.177 1.039 0.843 1.009 1.105 0.906 1.032 0.999 0.982 1.188 1.020 1.007 1.004

hsa-let-7i*-4395283 1 1 1 1.168 1.692 0.817 0.788 1.596 1.03 1.052 1.063 0.512 0.944 0.851 0.695 1.226 1.138 0.876 0.830

hsa-miR-100-4373160 1 1 1 0.565 1.147 1.099 0.449 0.948 6.866 0.571 1.009 1.442 0.453 0.836 1.088 0.937 2.754 1.007 0.792

hsa-miR-101-4395364 1 1 1 1.03 1.157 0.814 1.039 1.104 1.039 1.17 1.095 0.971 0.982 1.078 1.111 1.000 1.061 1.079 1.057

hsa-miR-103-4373158 1 1 1 0.988 0.92 0.947 1.031 0.876 0.93 0.987 0.96 0.852 0.946 0.833 1.013 0.952 0.946 0.933 0.931

hsa-miR-106a-4395280 1 1 1 1.098 1.037 0.732 1.106 1.015 0.812 1.012 0.986 0.811 1.018 0.909 0.865 0.956 0.978 0.936 0.931

hsa-miR-106b*-4395491 1 1 1 0.928 0.999 1.107 1.094 0.734 0.934 0.879 1.03 0.971 0.741 0.928 1.04 1.011 0.921 0.960 0.903

hsa-miR-106b-4373155 1 1 1 1.335 1.215 0.965 1.262 1.048 0.897 1.15 0.999 0.881 1.083 0.912 0.996 1.172 1.069 1.010 0.997

hsa-miR-10a-4373153 1 1 1 0.936 0.874 1.141 0.9 0.865 0.969 0.87 0.843 1.003 0.9 0.825 1.039 0.984 0.911 0.905 0.921

hsa-miR-122-4395356 1 1 1 0.642 0.99 1.278 0.717 0.693 1.044 0.819 1.088 1.273 0.64 1.14 1.44 0.970 0.818 1.060 1.073

hsa-miR-125a-3p-4395310 1 1 1 2.254 3.529 2.002 0.601 1.104 1.013 1.086 2.223 0.926 1.044 0.955 1.25 2.595 0.906 1.412 1.083

hsa-miR-125a-5p-4395309 1 1 1 1.053 1.297 0.789 0.717 0.996 0.954 0.883 1.11 0.727 0.718 0.913 0.81 1.046 0.889 0.907 0.814

hsa-miR-125b-4373148 1 1 1 1.126 1.485 1.016 1.268 0.908 1.136 1.153 1.102 1.092 0.792 0.891 1.046 1.209 1.104 1.116 0.910

hsa-miR-126*-4373269 1 1 1 1.206 1.254 0.707 0.912 1.065 0.895 1.038 1.258 0.933 0.91 0.928 0.881 1.056 0.957 1.076 0.906

hsa-miR-126-4395339 1 1 1 1.064 1.09 0.817 0.981 1.026 0.895 1.188 1.129 0.944 1.172 0.988 0.904 0.990 0.967 1.087 1.021

hsa-miR-127-3p-4373147 1 1 1 0.558 0.712 0.904 0.498 0.886 0.998 0.794 1.106 0.694 0.536 0.962 0.874 0.725 0.794 0.865 0.791

hsa-miR-128-4395327 1 1 1 0.825 1.073 0.835 0.961 1.041 0.763 0.854 1.025 0.731 0.832 1.006 0.819 0.911 0.922 0.870 0.886

hsa-miR-130a-4373145 1 1 1 0.921 1.174 1.124 0.993 0.891 1.087 0.774 0.828 0.847 0.755 0.74 1.23 1.073 0.990 0.816 0.908

hsa-miR-130b*-4395225 1 1 1 1.017 1.203 0.48 0.857 1.296 0.764 0.869 1.456 0.619 0.844 0.885 0.658 0.900 0.972 0.981 0.796

hsa-miR-130b-4373144 1 1 1 0.696 1 0.909 0.778 1.066 1.181 0.95 1.173 0.961 0.738 0.972 1.184 0.868 1.008 1.028 0.965

MicroRNA expression in polarized macrophages

hsa-miR-132*-4395243 1 1 1 1.87 1.913 1.225 0.726 1.009 0.522 3.911 4.698 1.261 0.877 1.229 0.958 1.669 0.752 3.290 1.021

hsa-miR-132-4373143 1 1 1 1.301 1.798 0.852 0.939 0.986 0.738 1.902 1.889 0.921 0.838 0.834 0.844 1.317 0.888 1.571 0.839

hsa-miR-133a-4395357 1 1 1 0.818 1.049 0.59 0.818 0.964 0.68 0.895 0.89 0.706 0.81 0.755 9.268 0.819 0.821 0.830 3.611

hsa-miR-135a*-4395343 1 1 1 1.173 1.124 0.753 0.937 1.15 0.892 0.971 1.196 0.759 0.981 0.996 0.779 1.017 0.993 0.975 0.919

hsa-miR-135a-4373140 1 1 1 0.463 1.085 0.564 0.653 0.555 1.341 0.787 0.57 0.667 0.531 0.711 1.049 0.704 0.850 0.675 0.764

hsa-miR-135b-4395372 1 1 1 1.019 0.927 0.981 1.031 1.026 0.797 0.952 0.909 0.729 1.254 0.867 0.81 0.976 0.951 0.863 0.977

hsa-miR-136*-4395211 1 1 1 1.198 1.025 0.639 2.639 0.49 1.421 0.826 0.828 1.028 0.566 1.025 1.363 0.954 1.517 0.894 0.985

hsa-miR-137-4373301 1 1 1 1.872 0.865 1.051 2.238 0.461 1.729 2.002 0.652 1.26 1.585 0.922 1.794 1.263 1.476 1.305 1.434

hsa-miR-138-1*-4395273 1 1 1 0.856 1.202 1.616 1.054 1.164 1.29 0.803 1.124 1.636 1.005 1.656 1.644 1.225 1.169 1.188 1.435

hsa-miR-138-4395395 1 1 1 0.986 1.633 0.827 1.358 1.145 0.761 0.96 1.206 0.88 1.004 1.217 0.811 1.149 1.088 1.015 1.011

hsa-miR-139-5p-4395400 1 1 1 0.893 0.808 0.542 0.719 0.744 0.678 1.191 1.17 0.801 0.751 0.874 1.153 0.748 0.714 1.054 0.926

hsa-miR-140-3p-4395345 1 1 1 1.009 0.968 0.713 0.98 1.012 0.756 1.073 1.045 0.926 1.062 0.963 0.919 0.897 0.916 1.015 0.981

hsa-miR-140-5p-4373374 1 1 1 0.836 1.019 0.773 0.826 1.003 0.804 0.852 1.057 0.762 0.885 1.006 0.928 0.876 0.878 0.890 0.940

hsa-miR-141-4373137 1 1 1 1.385 1.165 1.053 1.181 0.884 1.189 1.547 0.954 1.045 1.424 0.902 1.665 1.201 1.085 1.182 1.330

hsa-miR-142-3p-4373136 1 1 1 1.214 1.256 0.933 1 1.055 1.216 1.181 1.045 0.981 0.949 0.971 1.402 1.134 1.090 1.069 1.107

hsa-miR-142-5p-4395359 1 1 1 1.197 1.391 1.121 1.271 1.274 1.34 1.308 1.151 1.083 1.098 1.206 1.563 1.236 1.295 1.181 1.289

hsa-miR-1-4395333 1 1 1 1.293 1.304 0.786 1.426 1.019 0.579 0.937 3.645 0.41 0.997 1.777 0.751 1.128 1.008 1.664 1.175

hsa-miR-144*-4395259 1 1 1 0.889 1.095 2.811 0.834 0.585 2.645 0.357 0.767 2.025 0.877 0.472 2.617 1.598 1.355 1.050 1.322

hsa-miR-145-4395389 1 1 1 0.796 0.893 0.639 0.953 0.916 0.715 0.982 0.917 0.864 0.873 0.775 0.776 0.776 0.861 0.921 0.808

hsa-miR-146a-4373132 1 1 1 1.152 1.223 1.222 1.077 0.99 0.827 1.254 1.06 0.946 0.974 0.839 0.917 1.199 0.965 1.087 0.910

hsa-miR-146b-3p-4395472 1 1 1 1.559 1.424 1.196 1.065 1.188 0.778 1.427 1.486 0.786 0.996 1.165 0.873 1.393 1.010 1.233 1.011

hsa-miR-146b-5p-4373178 1 1 1 0.894 1.258 0.954 0.871 1.079 0.89 0.967 1.157 0.843 0.833 0.991 0.914 1.035 0.947 0.989 0.913

hsa-miR-147b-4395373 1 1 1 1.507 1.478 1.601 0.908 0.692 0.865 1.618 1.409 1.327 1.111 1.02 1.042 1.529 0.822 1.451 1.058

hsa-miR-148a-4373130 1 1 1 0.671 1.307 1.24 0.921 1.143 1.026 0.872 1.404 1.013 0.82 1.044 1.021 1.073 1.030 1.096 0.962

hsa-miR-148b*-4395271 1 1 1 1.047 0.872 0.902 0.849 1.097 0.85 0.884 0.943 0.917 0.942 0.905 1.012 0.940 0.932 0.915 0.953

hsa-miR-148b-4373129 1 1 1 1.059 1.098 1.255 1.019 1.215 1.03 1.134 1.376 1.042 0.993 1.024 0.941 1.137 1.088 1.184 0.986

hsa-miR-150-4373127 1 1 1 0.958 1.24 0.88 0.966 1.153 0.955 0.929 1.108 0.904 0.93 1.006 0.965 1.026 1.025 0.980 0.967

hsa-miR-151-3p-4395365 1 1 1 1.229 0.899 0.723 1.015 1.21 0.946 1.168 0.969 0.693 1.021 0.831 0.84 0.950 1.057 0.943 0.897

hsa-miR-152-4395170 1 1 1 0.843 0.957 1.018 0.905 1.011 1.006 0.931 1.028 0.945 0.859 0.85 1.047 0.939 0.974 0.968 0.919

hsa-miR-155*-4395398 1 1 1 4.817 4.126 8.945 1.098 2.162 0.95 5.804 6.338 4.174 0.519 0.712 0.837 5.963 1.403 5.439 0.689

hsa-miR-155-4395459 1 1 1 1.15 1.254 1.29 0.633 0.953 0.717 0.819 1.476 1.24 0.484 0.95 0.978 1.231 0.768 1.178 0.804

hsa-miR-15a*-4395530 1 1 1 1.087 1.388 0.696 1.306 1.763 1.066 0.948 1.369 0.755 1.045 1.596 0.974 1.057 1.378 1.024 1.205

hsa-miR-15b-4373122 1 1 1 0.96 1.217 1.094 0.995 0.981 1.063 0.998 1.048 0.917 0.941 0.916 1.085 1.090 1.013 0.988 0.981

hsa-miR-16-1*-4395531 1 1 1 1.426 0.823 0.825 1.478 1.253 1.246 0.896 0.833 0.68 1.431 1.283 1.352 1.025 1.326 0.803 1.355

MicroRNA expression in polarized macrophages

hsa-miR-16-4373121 1 1 1 0.577 0.979 0.966 0.751 0.874 0.786 0.661 0.991 0.775 0.638 0.991 0.764 0.841 0.804 0.809 0.798

hsa-miR-17-4395419 1 1 1 0.899 1.203 0.91 0.787 1.128 0.848 0.738 1.158 0.869 0.762 0.992 0.971 1.004 0.921 0.922 0.908

hsa-miR-181a*-4373086 1 1 1 0.524 0.399 0.597 0.577 0.594 0.962 0.485 0.379 0.84 0.803 0.6 1.109 0.507 0.711 0.568 0.837

hsa-miR-181a-2*-4395428 1 1 1 0.832 0.887 1.276 1.031 1.334 1.22 0.726 0.929 1.076 1.259 1.209 1.022 0.998 1.195 0.910 1.163

hsa-miR-184-4373113 1 1 1 0.847 0.797 1.519 0.987 0.553 0.604 1.011 0.872 1.29 0.776 0.403 1.211 1.054 0.715 1.058 0.797

hsa-miR-185-4395382 1 1 1 0.997 0.947 0.973 1.264 1.027 1.117 1.131 0.899 1.074 1.166 0.944 1.266 0.972 1.136 1.035 1.125

hsa-miR-186-4395396 1 1 1 0.847 1.133 0.792 1.062 1.01 0.92 0.854 1.168 0.782 1.133 1.044 0.889 0.924 0.997 0.935 1.022

hsa-miR-188-5p-4395431 1 1 1 1.118 1.299 0.748 1.172 1.314 1.134 1.154 1.252 0.73 1.182 1.293 0.876 1.055 1.207 1.045 1.117

hsa-miR-18a*-4395534 1 1 1 1.07 1.071 0.961 1.201 1.362 1.202 0.774 0.883 0.649 1.224 0.973 0.892 1.034 1.255 0.769 1.030

hsa-miR-18a-4395533 1 1 1 0.968 1.096 1.012 1.015 1.068 0.789 0.921 1.131 0.803 0.84 0.911 0.924 1.025 0.957 0.952 0.892

hsa-miR-190-4373110 1 1 1 0.747 1.055 0.91 0.821 0.98 1.115 1.297 0.845 0.758 0.803 0.985 1.232 0.904 0.972 0.967 1.007

hsa-miR-190b-4395374 1 1 1 1.31 1.038 0.661 1.089 1.1 0.816 1.194 1.048 0.95 1.084 1.068 0.799 1.003 1.002 1.064 0.984

hsa-miR-191-4395410 1 1 1 0.971 1.054 0.845 1.104 1.112 0.889 1.035 1.073 0.786 1.11 1.039 1.067 0.957 1.035 0.965 1.072

hsa-miR-192*-4395383 1 1 1 1.55 0.654 1.415 0.929 0.958 0.97 1.743 1.342 1.995 1.899 0.569 0.947 1.206 0.952 1.693 1.138

hsa-miR-192-4373108 1 1 1 0.961 1.079 0.999 0.998 0.981 0.926 1.209 1.288 1.232 0.95 0.889 0.94 1.013 0.968 1.243 0.926

hsa-miR-193a-3p-4395361 1 1 1 1.571 1.457 1.178 1.342 1.281 1.261 1.767 1.491 1.225 1.02 1.398 1.428 1.402 1.295 1.494 1.282

hsa-miR-193a-5p-4395392 1 1 1 0.909 1.055 0.988 0.883 0.988 0.868 1.072 1.167 0.855 1.012 1.064 1.079 0.984 0.913 1.031 1.052

hsa-miR-193b-4395478 1 1 1 0.744 0.95 0.897 1.72 3.665 1.558 0.751 0.785 0.799 0.768 0.867 0.782 0.864 2.314 0.778 0.806

hsa-miR-194-4373106 1 1 1 1.107 1.219 1.098 1.122 0.855 0.839 1.339 1.237 0.942 1.115 0.827 0.892 1.141 0.939 1.173 0.945

hsa-miR-195-4373105 1 1 1 1.264 1.006 0.939 1.184 1.152 1.037 1.15 1.044 0.989 1.332 0.923 1.032 1.070 1.124 1.061 1.096

hsa-miR-196b-4395326 1 1 1 0.734 0.671 1.011 0.835 0.764 0.868 1.153 0.886 1.194 0.891 0.612 0.929 0.805 0.822 1.078 0.811

hsa-miR-199a-3p-4395415 1 1 1 0.962 0.957 0.861 1.086 0.879 0.778 1.034 1.003 0.933 0.906 0.864 0.896 0.927 0.914 0.990 0.889

hsa-miR-19a-4373099 1 1 1 0.892 0.931 0.912 0.787 0.982 0.896 0.787 0.8 0.831 0.777 0.914 0.975 0.912 0.888 0.806 0.889

hsa-miR-19b-1*-4395536 1 1 1 1.262 0.977 0.843 1.264 1.385 1.064 1.037 0.922 0.843 1.085 1.021 1.194 1.027 1.238 0.934 1.100

hsa-miR-19b-4373098 1 1 1 1.014 1.069 0.937 1.022 0.96 0.856 1.037 0.953 0.844 0.963 0.889 0.958 1.007 0.946 0.945 0.937

hsa-miR-200b-4395362 1 1 1 0.647 1.054 0.815 0.667 0.85 0.732 0.637 1.073 0.872 0.64 0.83 1.077 0.839 0.750 0.861 0.849

hsa-miR-200c-4395411 1 1 1 1.021 1.103 1.031 0.952 0.876 0.784 0.906 1.002 0.751 0.958 0.851 1.17 1.052 0.871 0.886 0.993

hsa-miR-203-4373095 1 1 1 1.399 1.499 0.731 1.526 1.481 0.982 1.412 1.448 0.764 1.49 0.859 0.901 1.210 1.330 1.208 1.083

hsa-miR-206-4373092 1 1 1 1.146 0.466 1.132 0.969 0.739 0.484 0.771 0.644 0.557 1.476 0.373 0.841 0.915 0.731 0.657 0.897

hsa-miR-20a*-4395548 1 1 1 1.426 1.215 0.918 1.178 1.353 1.055 1.193 0.983 0.985 1.048 0.933 0.931 1.186 1.195 1.054 0.971

hsa-miR-20a-4373286 1 1 1 1.042 0.913 0.901 0.834 0.867 0.958 1.093 0.885 0.922 0.833 0.819 1.015 0.952 0.886 0.967 0.889

hsa-miR-20b-4373263 1 1 1 0.86 0.98 1.01 0.902 0.881 0.938 0.873 0.918 0.972 0.922 0.887 1.044 0.950 0.907 0.921 0.951

hsa-miR-21*-4395549 1 1 1 1.762 1.508 0.918 1.749 2.191 1.616 1.549 1.333 0.866 1.108 1.024 0.94 1.396 1.852 1.249 1.024

hsa-miR-210-4373089 1 1 1 0.864 1.351 1.102 0.897 0.99 0.886 0.843 1.711 1.039 0.674 0.982 0.984 1.106 0.924 1.198 0.880

MicroRNA expression in polarized macrophages

hsa-miR-212-4373087 1 1 1 1.743 2.09 0.793 1.105 1.082 0.841 2.665 2.428 0.987 1.222 0.885 1.006 1.542 1.009 2.027 1.038

hsa-miR-21-4373090 1 1 1 0.756 1.108 1.183 0.774 0.962 0.885 0.748 0.997 0.831 0.614 0.862 0.959 1.016 0.874 0.859 0.812

hsa-miR-218-4373081 1 1 1 0.939 1.318 0.92 0.908 1.106 0.996 1.032 1.079 0.966 0.821 0.933 1.045 1.059 1.003 1.026 0.933

hsa-miR-22*-4395412 1 1 1 1.25 1.041 0.95 0.95 0.948 1.118 1.191 1.022 0.967 0.964 0.864 0.92 1.080 1.005 1.060 0.916

hsa-miR-221*-4395207 1 1 1 2.033 0.986 1.327 1.17 1.105 1.35 1.485 0.791 1.085 0.998 0.646 1.145 1.449 1.208 1.120 0.930

hsa-miR-221-4373077 1 1 1 0.564 0.778 0.58 0.922 1.107 0.977 0.963 1.369 0.76 0.838 1.104 0.999 0.641 1.002 1.031 0.980

hsa-miR-222*-4395208 1 1 1 0.696 0.812 0.338 1.649 1.428 1.356 3.7 3.197 0.644 1.211 0.985 0.984 0.615 1.478 2.514 1.060

hsa-miR-222-4395387 1 1 1 0.853 1.369 0.892 1.07 1.195 1.045 1.269 1.237 0.858 0.924 1.056 0.911 1.038 1.103 1.121 0.964

hsa-miR-223*-4395209 1 1 1 1.127 0.925 0.904 1.014 0.934 1.011 1.124 0.942 0.894 0.991 0.843 1.061 0.985 0.986 0.987 0.965

hsa-miR-223-4395406 1 1 1 0.919 1.091 0.866 0.883 1.228 0.936 1.288 1.319 0.919 0.989 1.206 1.093 0.959 1.016 1.175 1.096

hsa-miR-24-4373072 1 1 1 0.811 0.881 0.821 0.703 0.811 0.823 0.916 0.867 0.779 0.841 0.773 0.885 0.838 0.779 0.854 0.833

hsa-miR-25-4373071 1 1 1 0.943 1.036 0.702 0.875 0.954 0.808 0.97 1.01 0.794 0.822 0.868 0.874 0.894 0.879 0.925 0.855

hsa-miR-26a-2*-4395226 1 1 1 0.296 0.001 0.376 1.034 1.034 1.276 0.497 0.38 0.988 0.876 0.806 1.281 0.224 1.115 0.622 0.988

hsa-miR-26a-4395166 1 1 1 0.792 1.132 0.983 0.909 1.075 0.907 0.916 1.165 0.871 0.872 0.998 1.07 0.969 0.964 0.984 0.980

hsa-miR-26b*-4395555 1 1 1 1.052 0.797 0.515 1.045 1.301 0.806 1.148 1.045 0.645 1.032 0.963 0.796 0.788 1.051 0.946 0.930

hsa-miR-26b-4395167 1 1 1 0.997 1.065 0.817 0.969 0.962 0.938 1.1 1.024 0.834 0.993 1.007 1.132 0.960 0.956 0.986 1.044

hsa-miR-27a*-4395556 1 1 1 1.321 1.234 0.866 0.909 0.979 0.788 2.764 2.515 1.084 1.013 1.211 1.109 1.140 0.892 2.121 1.111

hsa-miR-27a-4373287 1 1 1 0.919 1.018 0.686 1.083 1.123 0.857 1.35 1.383 0.923 1.132 1.114 1.099 0.874 1.021 1.219 1.115

hsa-miR-28-3p-4395557 1 1 1 0.972 1.005 0.847 0.949 0.978 0.863 0.917 0.962 0.822 0.945 0.887 0.952 0.941 0.930 0.900 0.928

hsa-miR-28-5p-4373067 1 1 1 0.814 1.054 1.106 0.868 0.943 0.955 0.811 1.002 0.879 0.776 0.868 1.051 0.991 0.922 0.897 0.898

hsa-miR-29a*-4395558 1 1 1 1.537 1.268 1.239 0.947 1.206 1.209 1.881 1.446 1.15 0.97 0.869 1.001 1.348 1.121 1.492 0.947

hsa-miR-29a-4395223 1 1 1 1.07 1.021 1.144 1.025 0.879 0.809 1.19 1.098 0.886 0.871 0.86 0.844 1.078 0.904 1.058 0.858

hsa-miR-29b-1*-4395276 1 1 1 1.998 1.111 3.112 0.896 0.465 0.768 4.911 2.446 2.274 0.601 0.887 0.733 2.074 0.710 3.210 0.740

hsa-miR-29b-2*-4395277 1 1 1 0.965 0.959 1.243 0.692 0.829 1.031 0.818 0.684 0.758 0.873 0.599 0.798 1.056 0.851 0.753 0.757

hsa-miR-29b-4373288 1 1 1 1.571 1.573 0.957 0.962 1.116 0.996 1.446 1.265 0.974 0.868 1.269 1.213 1.367 1.025 1.228 1.117

hsa-miR-29c*-4381131 1 1 1 1.043 1.107 0.75 0.994 1.312 1.003 0.866 1.066 0.765 0.855 1.01 0.9 0.967 1.103 0.899 0.922

hsa-miR-29c-4395171 1 1 1 1.212 1.082 0.964 1.011 0.879 1.118 1.342 0.927 1.081 0.94 0.904 1.147 1.086 1.003 1.117 0.997

hsa-miR-301a-4373064 1 1 1 1.241 1.134 0.599 1.146 1.173 0.849 1.413 1.289 0.847 1.194 1.085 0.959 0.991 1.056 1.183 1.079

hsa-miR-301b-4395503 1 1 1 0.766 1.061 0.779 0.899 1.153 0.986 0.902 1.398 0.872 0.852 0.996 0.959 0.869 1.013 1.057 0.936

hsa-miR-30a*-4373062 1 1 1 0.969 0.646 0.908 0.72 0.99 1.154 0.899 0.916 1.35 0.733 0.933 1.048 0.841 0.955 1.055 0.905

hsa-miR-30a-4373061 1 1 1 1.191 1.01 0.79 0.967 1.046 0.952 1.201 1.025 0.886 0.986 0.83 0.919 0.997 0.988 1.037 0.912

hsa-miR-30b-4373290 1 1 1 0.938 0.963 0.939 0.874 0.88 0.881 0.922 0.902 0.871 0.872 0.825 1.042 0.947 0.878 0.898 0.913

hsa-miR-30c-4373060 1 1 1 0.922 0.946 0.979 0.955 0.744 0.822 0.813 0.808 0.738 0.857 0.73 0.969 0.949 0.840 0.786 0.852

hsa-miR-30d*-4395416 1 1 1 0.67 0.631 0.615 0.845 1.238 0.922 0.807 0.869 0.827 0.892 0.962 0.973 0.639 1.002 0.834 0.942

MicroRNA expression in polarized macrophages

hsa-miR-30d-4373059 1 1 1 1.072 0.977 0.813 0.812 0.944 0.924 1.102 0.904 0.726 0.859 0.704 0.769 0.954 0.893 0.911 0.777

hsa-miR-30e*-4373057 1 1 1 1.009 0.975 0.699 0.963 1.178 0.88 1.123 1.015 0.725 0.944 0.969 0.858 0.894 1.007 0.954 0.924

hsa-miR-30e-4395334 1 1 1 1.299 1.2 0.808 1.08 1.293 0.983 1.331 1.104 0.862 1.046 1.079 0.951 1.102 1.119 1.099 1.025

hsa-miR-31-4395390 1 1 1 0.968 0.924 1.069 1.074 0.938 1.004 0.939 0.866 1.013 0.931 0.76 0.978 0.987 1.005 0.939 0.890

hsa-miR-320-4395388 1 1 1 0.944 1.073 0.873 0.995 0.987 0.925 1.067 1.061 0.859 1.096 1.011 1.126 0.963 0.969 0.996 1.078

hsa-miR-32-4395220 1 1 1 1.607 0.878 1.07 1.295 0.946 1.203 1.958 0.777 0.857 1.249 0.802 1.518 1.185 1.148 1.197 1.190

hsa-miR-324-3p-4395272 1 1 1 0.915 0.807 0.741 0.987 0.982 0.684 0.977 0.848 0.729 1.007 0.817 0.879 0.821 0.884 0.851 0.901

hsa-miR-324-5p-4373052 1 1 1 0.802 1.261 1.017 1.032 1.181 1.122 0.967 1.115 0.86 0.746 1.203 1.049 1.027 1.112 0.981 0.999

hsa-miR-328-4373049 1 1 1 0.791 1.049 0.78 0.948 1.092 0.89 0.881 0.966 0.75 0.906 0.964 0.923 0.873 0.977 0.866 0.931

hsa-miR-331-3p-4373046 1 1 1 1.063 0.994 0.794 1.144 1.029 0.717 1.025 0.994 0.68 1.057 0.821 0.795 0.950 0.963 0.900 0.891

hsa-miR-335-4373045 1 1 1 0.686 0.803 1.238 0.792 0.692 1.328 0.509 0.694 2.196 0.489 0.597 1.393 0.909 0.937 1.133 0.826

hsa-miR-338-3p-4395363 1 1 1 0.922 1.558 0.869 1.274 1.132 1.027 1.01 1.11 1.075 0.998 1.019 0.972 1.116 1.144 1.065 0.996

hsa-miR-339-3p-4395295 1 1 1 0.744 0.818 0.604 0.913 0.881 0.835 0.702 0.718 0.699 0.963 0.972 0.871 0.722 0.876 0.706 0.935

hsa-miR-33a*-4395247 1 1 1 1.022 1.209 0.827 0.762 1.026 0.934 0.934 0.946 0.798 0.726 1.075 0.727 1.019 0.907 0.893 0.843

hsa-miR-340*-4395370 1 1 1 1.052 0.988 0.712 0.975 1.088 0.948 0.991 0.945 0.76 0.94 0.888 1.015 0.917 1.004 0.899 0.948

hsa-miR-340-4395369 1 1 1 0.947 0.791 0.807 0.976 0.795 1.055 1.08 0.827 0.911 1.002 0.788 1.295 0.848 0.942 0.939 1.028

hsa-miR-342-3p-4395371 1 1 1 1.03 1.056 0.68 1.017 0.916 0.846 1.046 0.888 0.764 1.051 0.886 1.012 0.922 0.926 0.899 0.983

hsa-miR-345-4395297 1 1 1 0.653 0.961 0.655 0.869 1.041 0.793 0.739 1.033 0.704 0.809 1.071 0.885 0.756 0.901 0.825 0.922

hsa-miR-34a*-4395427 1 1 1 1 1.015 0.818 0.829 1.123 0.984 0.97 0.883 0.851 1.018 1.016 1.062 0.944 0.979 0.901 1.032

hsa-miR-34a-4395168 1 1 1 0.958 1.184 0.888 0.98 1.087 0.849 1.078 1.071 0.843 0.881 0.975 0.914 1.010 0.972 0.997 0.923

hsa-miR-362-3p-4395228 1 1 1 1.012 1.16 0.908 0.906 1.103 1.042 1.307 0.952 0.996 0.864 0.965 1.236 1.027 1.017 1.085 1.022

hsa-miR-362-5p-4378092 1 1 1 0.781 0.922 0.778 0.806 0.843 0.89 0.715 0.891 0.808 0.803 0.893 1.046 0.827 0.846 0.805 0.914

hsa-miR-363-4378090 1 1 1 1.121 1.18 0.968 1.086 1.049 1.33 0.998 0.95 1.028 0.953 0.78 1.224 1.090 1.155 0.992 0.986

hsa-miR-365-4373194 1 1 1 0.865 0.912 0.674 0.841 0.915 0.819 1.103 0.91 0.745 0.866 0.771 0.943 0.817 0.858 0.919 0.860

hsa-miR-374a*-4395236 1 1 1 1.572 1.229 0.683 1.041 1.034 0.919 1.201 0.614 0.719 1.287 0.903 1.14 1.161 0.998 0.845 1.110

hsa-miR-374a-4373028 1 1 1 0.822 0.974 0.853 0.847 0.909 1.028 0.833 0.928 0.927 0.915 0.879 1.161 0.883 0.928 0.896 0.985

hsa-miR-374b*-4395502 1 1 1 0.678 0.516 2.32 1.442 1.682 4.971 0.613 0.453 4.45 0.413 1.172 4.644 1.171 2.698 1.839 2.076

hsa-miR-374b-4381045 1 1 1 0.752 1.166 0.768 0.876 1.117 0.907 0.821 1.093 0.846 0.978 1.127 1.135 0.895 0.967 0.920 1.080

hsa-miR-376a-4373026 1 1 1 0.795 0.759 0.919 1.056 0.935 0.994 0.915 0.542 0.964 0.779 0.725 1.035 0.824 0.995 0.807 0.846

hsa-miR-376c-4395233 1 1 1 0.847 1.037 0.743 0.68 0.895 1.055 1.016 0.908 0.946 1.067 0.815 0.954 0.876 0.877 0.957 0.945

hsa-miR-378*-4373024 1 1 1 1.048 0.867 0.888 0.886 1.384 1.153 1.092 1.023 1.032 0.891 0.954 1.125 0.934 1.141 1.049 0.990

hsa-miR-378-4395354 1 1 1 1.176 0.965 0.836 1.041 1.291 0.996 1.158 1.041 0.768 1.001 0.93 0.868 0.992 1.109 0.989 0.933

hsa-miR-409-3p-4395443 1 1 1 0.837 0.957 1.115 0.754 0.611 1.092 1.37 1.05 1.734 1.059 0.629 0.959 0.970 0.819 1.385 0.882

hsa-miR-411-4381013 1 1 1 3.127 0.742 0.775 1.014 0.832 0.805 0.867 0.92 1.099 1.874 0.845 0.62 1.548 0.884 0.962 1.113

MicroRNA expression in polarized macrophages

hsa-miR-422a-4395408 1 1 1 0.554 0.675 0.667 0.851 0.954 0.635 0.718 0.899 0.548 0.73 0.954 0.844 0.632 0.813 0.722 0.843

hsa-miR-424*-4395420 1 1 1 0.989 0.741 1.383 1.337 0.767 0.526 1.162 1.115 1.651 1.083 0.92 1.473 1.038 0.877 1.309 1.159

hsa-miR-424-4373201 1 1 1 1.184 1.18 1.107 1.291 1.073 1.046 1.214 1.157 0.891 0.88 0.909 0.855 1.157 1.137 1.087 0.881

hsa-miR-425*-4395413 1 1 1 0.794 1.068 0.629 0.781 1.406 1.02 0.829 1.243 0.701 0.848 1.066 0.85 0.830 1.069 0.924 0.921

hsa-miR-429-4373203 1 1 1 0.794 0.644 0.812 0.928 1.108 0.983 0.875 0.937 0.849 0.78 0.581 1.021 0.750 1.006 0.887 0.794

hsa-miR-449a-4373207 1 1 1 1.005 1.332 1.169 0.95 1.734 0.927 1.047 1.542 0.968 0.707 1.374 0.665 1.169 1.204 1.186 0.915

hsa-miR-449b-4381011 1 1 1 1.32 1.715 1.149 0.957 0.808 0.742 1.524 1.35 0.963 1.068 0.779 0.94 1.395 0.836 1.279 0.929

hsa-miR-450a-4395414 1 1 1 0.786 1.244 0.84 0.795 0.963 0.729 0.7 1.292 0.793 0.843 1.161 0.89 0.957 0.829 0.928 0.965

hsa-miR-451-4373360 1 1 1 0.97 1.114 1.102 1.003 1.481 1.207 0.678 1.424 1.252 0.86 1.282 0.828 1.062 1.230 1.118 0.990

hsa-miR-454*-4395185 1 1 1 1.351 0.703 0.753 1.043 0.895 0.993 1.312 0.831 0.705 1.088 0.791 0.901 0.936 0.977 0.949 0.927

hsa-miR-454-4395434 1 1 1 0.843 1.057 0.756 0.936 0.897 0.793 0.958 0.964 0.787 1.014 0.966 0.958 0.885 0.875 0.903 0.979

hsa-miR-483-5p-4395449 1 1 1 0.484 0.898 0.527 0.66 1.22 0.884 1.039 1.711 1.297 0.853 1.26 0.958 0.636 0.921 1.349 1.024

hsa-miR-484-4381032 1 1 1 0.838 0.879 0.723 0.934 0.845 0.715 0.994 0.825 0.712 0.891 0.866 0.777 0.813 0.831 0.844 0.845

hsa-miR-487b-4378102 1 1 1 0.85 1.336 0.932 0.765 2.231 0.584 0.457 2.281 1.601 0.959 1 1.385 1.039 1.193 1.446 1.115

hsa-miR-491-5p-4381053 1 1 1 0.87 0.986 0.962 0.899 0.873 0.973 0.892 0.976 0.893 0.887 0.925 1.06 0.939 0.915 0.920 0.957

hsa-miR-494-4395476 1 1 1 0.92 1.249 1.165 0.825 0.984 0.96 0.899 2.023 0.973 0.597 2.814 0.993 1.111 0.923 1.298 1.468

hsa-miR-495-4381078 1 1 1 0.83 2.398 2.471 0.618 3.683 1.728 0.684 1.958 2.486 0.871 1.869 2.435 1.900 2.010 1.709 1.725

hsa-miR-500*-4373225 1 1 1 0.938 0.875 0.894 1.022 0.888 1.584 0.641 0.678 0.56 0.927 1.05 1.124 0.902 1.165 0.626 1.034

hsa-miR-500-4395539 1 1 1 0.989 1.299 0.706 1.118 1.177 0.767 1.094 1.289 0.87 1.027 1.057 0.882 0.998 1.021 1.084 0.989

hsa-miR-502-3p-4395194 1 1 1 0.98 1.16 1.049 1.088 1.013 1.011 0.969 1.109 0.939 0.813 0.952 1.168 1.063 1.037 1.006 0.978

hsa-miR-502-5p-4373227 1 1 1 0.986 1.339 0.831 0.912 1.078 1.118 1.111 1.126 0.839 0.971 0.947 1.403 1.052 1.036 1.025 1.107

hsa-miR-503-4373228 1 1 1 0.96 1.285 1.649 0.929 1.957 1.287 0.875 1.589 1.32 0.872 1.706 1.404 1.298 1.391 1.261 1.327

hsa-miR-505*-4395198 1 1 1 1.028 1.136 0.773 0.808 1.051 0.959 0.822 0.96 0.823 0.886 0.84 0.91 0.979 0.939 0.868 0.879

hsa-miR-505-4395200 1 1 1 1.186 0.927 0.599 1.08 0.856 0.736 1.443 1.136 0.713 1.152 0.797 0.893 0.904 0.891 1.097 0.947

hsa-miR-509-3p-4395347 1 1 1 0.965 1.987 1.381 1.272 1.961 0.597 0.951 1.343 1.473 0.983 2.081 0.848 1.444 1.277 1.256 1.304

hsa-miR-511-4373236 1 1 1 1.024 1.049 0.694 1.176 1.125 0.79 1.065 1.056 0.728 1.062 0.967 0.774 0.922 1.030 0.950 0.934

hsa-miR-516a-3p-4373183 1 1 1 0.557 2.163 1.237 1.23 1.946 1.435 1.169 0.8 1.111 1.341 3.01 1.313 1.319 1.537 1.027 1.888

hsa-miR-520c-3p-4395511 1 1 1 1.958 1.159 0.993 0.856 1.209 1.359 1.025 0.559 0.588 1.285 0.789 1.226 1.370 1.141 0.724 1.100

hsa-miR-532-3p-4395466 1 1 1 0.834 1.118 0.829 0.901 1.013 0.764 0.809 1.02 0.704 0.781 0.903 0.851 0.927 0.893 0.844 0.845

hsa-miR-532-5p-4380928 1 1 1 0.885 1.09 0.756 0.942 1.083 0.81 0.96 1.141 0.729 1.022 0.991 0.873 0.910 0.945 0.943 0.962

hsa-miR-542-3p-4378101 1 1 1 0.926 1.059 0.635 0.892 1.191 1.898 0.937 1.183 1.387 0.752 0.863 1.492 0.873 1.327 1.169 1.036

hsa-miR-545*-4395377 1 1 1 0.763 0.912 0.567 0.647 0.787 0.965 1.028 0.542 0.755 0.868 0.941 1.087 0.747 0.800 0.775 0.965

hsa-miR-545-4395378 1 1 1 0.833 1.822 1.297 1.144 1.552 1.167 1.228 1.344 1.233 0.874 1.636 1.476 1.317 1.288 1.268 1.329

hsa-miR-548c-5p-4395540 1 1 1 1.387 0.689 1.024 3.308 1.212 1.31 2.713 1.08 1.339 2.859 1.01 1.367 1.033 1.943 1.711 1.745

MicroRNA expression in polarized macrophages

hsa-miR-565-4380942 1 1 1 1.409 1.167 1.638 1.139 0.829 1.57 1.059 0.892 1.309 0.784 0.978 1.624 1.405 1.179 1.087 1.129

hsa-miR-572-4381017 1 1 1 0.61 0.765 2.088 0.799 1.389 2.213 0.518 0.546 2.119 0.602 0.599 1.892 1.154 1.467 1.061 1.031

hsa-miR-574-3p-4395460 1 1 1 0.852 1.054 0.862 0.967 1.065 0.851 0.932 1.189 0.973 0.876 0.955 0.971 0.923 0.961 1.031 0.934

hsa-miR-576-3p-4395462 1 1 1 0.862 0.786 0.93 1.037 0.803 1.451 1.128 0.745 1.073 1.351 0.797 1.474 0.859 1.097 0.982 1.207

hsa-miR-579-4395509 1 1 1 1.049 1.251 0.941 1.002 0.821 0.956 0.968 1.158 0.826 0.891 1.005 0.974 1.080 0.926 0.984 0.957

hsa-miR-589*-4380953 1 1 1 0.966 0.493 0.869 0.838 0.591 0.937 0.9 0.64 1.147 0.904 0.406 1.347 0.776 0.789 0.896 0.886

hsa-miR-589-4395520 1 1 1 0.647 0.467 0.767 1.146 0.705 0.663 2.004 0.612 0.929 1.024 0.599 1.604 0.627 0.838 1.182 1.076

hsa-miR-590-5p-4395176 1 1 1 1.084 1.272 0.8 1.161 1.188 0.92 1.385 1.092 0.905 1.149 1.201 1.28 1.052 1.090 1.127 1.210

hsa-miR-597-4380960 1 1 1 1.151 1.002 1.018 1.434 1.329 0.915 1.135 1.253 0.803 1.058 1.142 1.116 1.057 1.226 1.064 1.105

hsa-miR-598-4395179 1 1 1 0.997 0.918 0.883 0.971 1.042 0.853 1.026 0.919 0.766 1.136 1.027 1.042 0.933 0.955 0.904 1.068

hsa-miR-601-4380965 1 1 1 0.81 0.994 0.946 0.719 1.164 1.359 1.106 1.27 1.374 1.005 1.492 1.166 0.917 1.081 1.250 1.221

hsa-miR-616*-4380992 1 1 1 1.117 0.994 0.713 1.017 1.004 0.753 1.054 1.034 0.641 0.865 0.938 0.913 0.941 0.925 0.910 0.905

hsa-miR-618-4380996 1 1 1 0.758 0.624 0.489 0.913 0.525 0.332 0.684 0.697 0.828 1.007 0.663 0.581 0.624 0.590 0.736 0.750

hsa-miR-624*-4380964 1 1 1 1.842 0.73 1.27 1.096 0.878 1.201 1.501 1.258 0.88 0.64 0.575 0.63 1.281 1.058 1.213 0.615

hsa-miR-625*-4395543 1 1 1 0.957 0.861 1.094 1.071 0.946 0.987 0.933 0.837 1.032 0.941 1.024 1.137 0.971 1.001 0.934 1.034

hsa-miR-625-4395542 1 1 1 0.679 0.928 1.022 0.837 0.942 0.922 0.778 0.889 0.805 0.96 0.984 1.039 0.876 0.900 0.824 0.994

hsa-miR-627-4380967 1 1 1 0.469 1.548 0.797 0.675 1.482 1.34 0.748 1.393 0.733 0.369 1.269 1.518 0.938 1.166 0.958 1.052

hsa-miR-628-3p-4395545 1 1 1 0.883 1.016 0.793 0.888 1.102 0.941 0.766 1.047 0.816 0.991 1.154 0.951 0.897 0.977 0.876 1.032

hsa-miR-628-5p-4395544 1 1 1 0.834 1.073 0.777 0.951 1.065 0.751 0.853 0.895 0.756 1.119 1.142 0.858 0.895 0.922 0.835 1.040

hsa-miR-629*-4380969 1 1 1 0.993 0.792 0.68 0.881 0.862 1.101 0.892 0.876 1.007 0.997 0.727 0.858 0.822 0.948 0.925 0.861

hsa-miR-629-4395547 1 1 1 1.28 1.131 0.728 1.365 0.952 0.82 1.182 1.26 0.793 1.474 1.074 1.077 1.046 1.046 1.078 1.208

hsa-miR-636-4395199 1 1 1 1.279 1.347 0.649 1.266 0.804 0.911 1.254 1.288 0.83 1.098 0.764 1.228 1.092 0.994 1.124 1.030

hsa-miR-642-4380995 1 1 1 0.948 1.194 0.921 0.968 0.992 1.062 1.26 1.037 1.08 0.844 0.925 1.204 1.021 1.007 1.126 0.991

hsa-miR-651-4381007 1 1 1 0.857 1.171 0.829 0.812 0.864 1.093 0.89 1.197 1.376 1.097 1.088 0.952 0.952 0.923 1.154 1.046

hsa-miR-652-4395463 1 1 1 0.947 1.008 0.89 1.074 1.032 0.848 1.092 1.023 0.8 0.938 0.983 0.97 0.948 0.985 0.972 0.964

hsa-miR-660-4380925 1 1 1 0.989 1.252 0.814 1.119 1.093 0.914 0.961 1.217 0.923 0.921 1.127 1.028 1.018 1.042 1.034 1.025

hsa-miR-671-3p-4395433 1 1 1 0.596 0.505 0.599 1.03 0.857 0.833 0.651 0.57 0.602 1.105 0.795 0.994 0.567 0.907 0.608 0.965

hsa-miR-708-4395452 1 1 1 0.997 1.329 0.85 0.979 1.248 0.823 1.119 1.276 1.042 1.109 1.244 0.894 1.059 1.017 1.146 1.082

hsa-miR-7-1*-4381118 1 1 1 0.961 1.053 1.196 0.941 0.914 0.924 1.132 1.108 0.87 0.861 0.943 0.857 1.070 0.926 1.037 0.887

hsa-miR-7-4378130 1 1 1 1.273 1.221 1.088 0.981 1.011 0.992 1.258 0.878 1.132 1.043 0.813 0.867 1.194 0.995 1.089 0.908

hsa-miR-744*-4395436 1 1 1 0.915 0.571 0.726 0.792 1.358 0.73 0.978 0.518 0.767 0.599 0.503 0.675 0.737 0.960 0.754 0.592

hsa-miR-744-4395435 1 1 1 0.853 0.932 0.841 0.913 0.897 0.854 0.943 1.046 0.864 0.886 0.908 0.884 0.875 0.888 0.951 0.893

hsa-miR-766-4395177 1 1 1 0.816 0.993 0.901 0.942 1.071 1.029 0.917 1.18 0.855 1.07 1.224 0.954 0.903 1.014 0.984 1.083

hsa-miR-768-3p-4395188 1 1 1 1.126 1.075 0.985 1.015 1.267 1.148 1.165 1.219 1.09 0.928 1 1.006 1.062 1.143 1.158 0.978

MicroRNA expression in polarized macrophages

hsa-miR-769-5p-4395186 1 1 1 0.872 0.93 0.933 1.06 1.064 1.091 0.87 0.96 0.836 1.001 1.01 1.013 0.912 1.072 0.889 1.008

hsa-miR-801-4395183 1 1 1 1.078 0.827 2.117 1.147 0.834 3.958 2.779 2.466 3.508 1.128 0.875 4.592 1.341 1.980 2.918 2.198

hsa-miR-875-5p-4395314 1 1 1 0.949 0.685 2.103 0.82 0.637 1.805 0.64 0.687 1.863 1.195 0.438 1.861 1.246 1.087 1.063 1.165

hsa-miR-877-4395402 1 1 1 1.195 1.007 0.842 0.96 1.117 0.969 0.965 0.889 0.749 1.117 1.074 0.95 1.015 1.015 0.868 1.047

hsa-miR-885-5p-4395407 1 1 1 0.852 1.25 0.625 1.058 0.916 0.767 1.017 1.067 0.734 1.002 1.002 1.027 0.909 0.914 0.939 1.010

hsa-miR-886-5p-4395304 1 1 1 1.192 1.352 1.199 0.97 0.915 1.159 1.052 0.862 0.981 0.865 0.807 1.911 1.248 1.015 0.965 1.194

hsa-miR-9*-4395342 1 1 1 1.2 1.298 0.882 0.996 1.005 1.063 1.233 1.121 1.041 0.927 0.922 1.283 1.127 1.021 1.132 1.044

hsa-miR-92a-1*-4395248 1 1 1 2.048 0.901 0.917 1.495 1.463 1.856 1.2 0.69 1.123 1.106 0.587 1.107 1.289 1.605 1.004 0.933

hsa-miR-92a-4395169 1 1 1 1.159 1.109 1.01 1.061 0.939 0.971 0.98 0.932 0.899 0.963 0.809 0.899 1.093 0.990 0.937 0.890

hsa-miR-93*-4395250 1 1 1 0.902 1.009 0.904 0.989 1.18 1.057 1.02 1.009 1.015 0.932 0.969 0.98 0.938 1.075 1.015 0.960

hsa-miR-93-4373302 1 1 1 0.805 1.015 0.867 0.899 1.032 0.927 0.888 1.011 0.941 0.924 0.954 1.051 0.896 0.953 0.947 0.976

hsa-miR-941-4395294 1 1 1 0.854 1.257 0.48 1.052 1.049 1.056 0.561 1.06 0.374 0.745 1.192 0.935 0.864 1.052 0.665 0.957

hsa-miR-942-4395298 1 1 1 0.868 0.741 0.915 0.751 1.063 0.852 0.867 0.864 1.089 0.789 0.765 1.002 0.841 0.889 0.940 0.852

hsa-miR-9-4373285 1 1 1 0.718 1.148 1.219 0.696 0.94 1.069 0.752 1.027 1.094 0.615 0.776 0.961 1.028 0.902 0.958 0.784

hsa-miR-95-4373011 1 1 1 0.958 1.134 1.022 0.986 0.978 1.058 0.971 1.131 1.081 0.947 0.969 1.145 1.038 1.007 1.061 1.020

hsa-miR-99b*-4395307 1 1 1 0.911 1.143 0.879 0.79 1.278 0.756 1.442 1.207 0.581 1.115 1.25 0.77 0.978 0.941 1.077 1.045

Human MDMs were incubated in M1-, M2a-, M2b-, or M2c-polarizing conditions for 8 hours. RNA was collected and analyzed using a TaqMan Low Density Array from Applied Biosystems to determine miRNA expression. Data in the table indicate the fold change in expression of the indicated miRNA following exposure to polarizing treatment in each of three independent monocyte-derived macrophage (MDM) preparations. Changes in miRNA expression in treated relative to no treatment samples were calculated by the

Ct method, using RNU48 as an endogenous control. The mean fold change is indicated in the final 4 columns (n=3). D1 = MDM donor 1; D2 = MDM donor 2; D3 = MDM donor 3