Table of Refrence

8/9/2019 Table of Refrence

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Fetomaternal

Prem

atureRuptureofM

embrane(PROM)

Bopegamagea S, Kacerov M, Tamborc V, Musilovab I,

Sarmirovaa S, Snelerse !, et al" Preterm prelaborrupture of membranes (PPROM) is not associate#it$presence of viral genomes in t$e amniotic %ui"

&ournal of 'linical Virolog" *+"

Background- T$e role of viral infections in pretermprelabor rupture of t$e membranes (PPROM) isnotestablis$e" Stuies on t$e presence of viralgenomes in t$e amniotic %ui (./) collecte inpregnanciescomplicate b PPROM s$o#

contraictor outcomes"Objectives- To investigate ./ samples of PPROMpregnancies for t$e presence of viral genomes"Study design- ./ samples from patients #it$ PPROM#ere collecte uring a 01ear (**23*+) obser1vational stu" +40 #omen #ere inclue #it$selection criteria of singleton pregnanc, PPROM,anmaternal age of +2 ears an above" P'R #asuse for etection of $uman ctomegalovirus(5'MV),$erpes simple6 virus (5SV), parvovirus B+7,$uman aenoviruses (5.V), enteroviruses (!V) an$umanparec$ovirus (5PeV)" T$e selection of t$ese

viral targets #as base on literature regaringscreening of./ for presence of viral genomes"Results- Onl a single sample #as positive out of t$e+40 teste ./s, 5'MV 89. #as etecte"


2/20

Conclusions- PPROM is not associate #it$ activeviral infections"


3/20

/u:imoto T, Parr S, ;rbane< M, Sammel M, Macones=, Kuivaniemi 5, et al" . Single 9ucleotie

Polmorp$ism in t$e Matri6 Metalloproteinase1+ (MMP1+) Promoter In%uences .mnion 'ell MMP1+ !6pressionan Ris< for Preterm Premature Rupture of t$e /etalMembranes" T5! &O;R9.> O/ BIO>O=I'.>'5!MISTR?" **@44"

Interstitial collagen gives fetal membranes tensilestrengt$, an membrane rupture $as been attributeto collagen egraation" . polmorp$ism at +A*4 int$e matri6 metalloproteinase1+ (MMP1+) promoter (aninsertion of a guanine (=)) creates a core !ts biningsite an increases promoter activit" e investigate#$et$er t$is polmorp$ism is functionall signiCcant

for MMP1+ e6pression in amnion cells an #$et$er it isassociate #it$ preterm premature rupture of t$emembranes (PPROM)" T$e = promoter $a D1folgreater activit t$an t$e += allele in amnionmesenc$mal cells an IS5 amnion cells" P$orbol+1mristate +1acetate (PM.) increasemesenc$mal cell nuclear protein bining #it$greater aEnit to t$e = allele" Inuction of MMP1+mR9. b PM. #as signiCcantl greater in cells #it$ a+=F= or =F= genotpe compare #it$ cells$omoGgous for t$e += allele" $en treate #it$ PM.,t$e +=F= an =F= cells prouce greater amounts

of MMP1+ protein t$an +=F+= cells". signiCcant association #as foun bet#een fetalcarriage of a = allele an PPROM"e conclue t$at t$e = allele $as stronger promoter


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activit in amnion cells, t$at it confers increaseresponsiveness of amnion cells to stimuli t$at inuceMMP1+, an t$at t$is polmorp$ism contributes to t$eris< of PPROM"


5/20

=eta$un 8, Stric


6/20

#omen"CO$C%SIO$- omen #it$ previous PPROM areat increase ris< for recurrence, an a s$ort IPI isassociate #it$ increase ris


7/20

Table Of Refrence

5am 8Pv, 5een &>v, Opmeer B', Muler .>M,

Moonen RM&, Bee< &v, et al" Management of late1preterm premature rupture of membranes- t$ePPROM!JI>1 trial" *+"

OBJECTIVE- T$e evience for t$e management ofnear term prelabor rupture of membranes is poor"/rom &anuar **4 until September **7, #eperforme t$e PPROM !6pectant Managementversus Inuction of >abor (PPROM!JI>) trial" In t$istrial, #e s$o#e t$at in #omen #it$ pretermprelabor rupture of membranes (PPROM), t$eincience of neonatal sepsis #as lo#, an t$einuction of labor (Io>) i not reuce t$is ris or e6pectantmanagement (!M)" T$e primar outcome measure#as neonatal sepsis" R!S;>TS- /rom 8ecember **7until &anuar *++, #e ranomiGe

+** #omen to Io> an 7H to !M" 9eonatal sepsis #asseen in neonates ("*) in t$e Io>1group versus 0neonates (0"+) in t$e !M group (relative ris


8/20

sepsis cases in t$e Io> group resulte in neonataleat$ because of asp$6ia" T$ere #ere nosigniCcant iLerences in seconar outcomes"CO$C%SIO$- T$e ris< of neonatal sepsis afterPPROM near term is lo#" Inuction of labor oes notreuce t$is ris


9/20

Mercer BM, 'rouse 8T, =olenberg R>, Mioovni< M, Mapp

8', Meis P&, et al" T$e antibiotic treatment of PPROM stu-sstemic maternal an fetal mar


10/20

preictive values for perinatal outcomes"CO$C%SIO$- ;mbilical cor bloo cto


11/20

Morris &M, Roberts '>, 'ro#t$er '., Buc$anan S>, 5enerson 8&, Sal


12/20

"c$orioamnionitis, postpartum infection treate #it$ antibiotics,antepartum $aemorr$age, inuction of labour, moe of eliver, maternalsatisfaction #it$ care, uration of $ospitalisation, an maternal #ellbeingat four mont$s postpartum"!iscussion- T$is trial #ill provie evience on t$e optimal care for #omen#it$ PPROM close to term (034 #ee


13/20

MR 8, P M, '. ', V& /, Varat$ara:u"

Planne earl birt$ versus e6pectantmanagement (#aiting) for prelabourrupture of membranes at term (4#eeibrar,Issue 0, **0), M!8>I9! (+7AA to9ovember **0) an !MB.S! (+740 to9ovember **0)" Selection criteriaRanomise or Nuasi1ranomise trialsof planne earl birt$ compare #it$e6pectant management in #omen #it$prelabour rupture of membranes at 4#ee


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t$e planne compare #it$ e6pectantmanagement groups $ac$orioamnionitis (RR *"40, 7H 'I *"HAto *"74@ 7 trials, AA++ #omen) orenometritis (RR *"*, 7H 'I *"+ to*"40@ 0 trials, 00H #omen)" 9o iLerence#as seen for neonatal infection (RR

*"2, 7H'I *"A+ to +"+@ 7 trials, A0*Ainfants)" 5o#ever, fe#er infants uner

guie #$en planning eliver in t$e 1to 01#ee< interval" . gestational ageapproac$ to t$erap is important ans$oul be a:uste for eac$ $ospitalsneonatal intensive care unit" .ntenatalantibiotics an corticosteroi t$erapies$ave clear beneCts an s$oul beoLere to all #omen #it$out


15/20

Singla ., ?aav P, Vai 9B, Sune:a .,Mo$amma, /arii" Transabominal

amnioinfusion in preterm prematurerupture of membranes" International

&ournal of =necolog an Obstetrics"*+*@+*2"

Ob:ective- To evaluate t$e eLect of

transabominal amnioinfusion onprolongation of pregnanc, an maternalan neonatal outcomes in pretermpremature rupture of membranes(pPROM)"Met$os- e conucte a prospectiveranomiGe controlle stu of #omen#it$ pPROM uring singleton livepregnancQbet#een A an A #ee


16/20

neonatal sepsis, an neonatal mortalit" Int$e stu group, more participantselivere spontaneousl an t$ere #erefe#er cases of postpartum sepsis,alt$oug$ t$e pPROM3eliver interval #asnot increase"


17/20

Stuart !>, !vans =S, >in ?S, Po#ers 5&" Reuce

'ollagen an .scorbic .ci 'oncentrations anIncrease Proteoltic Susceptibilit #it$ Prelabor/etal Membrane Rupture in omen" BIO>O=? O/R!PRO8;'TIO9" **0@4"

Prelabor rupture of t$e fetal membranes aLectsappro6imatel +* of #omen at term, resulting inan increase ris< of maternal an neonatalinfection" !vience suggests t$at membranerupture is relate to bioc$emical processesinvolving t$e e6tracellular matri6 of t$emembranes" e teste t$e $pot$esis t$atprelabor rupture membranes are c$aracteriGeb reuce collagen concentrations, alterecollagen cross1lin< proCles, an increaseconcentrations of biomar


18/20

t$e amniotic sac" Our Cnings are stronglsupportive of a role for t$e en$ance egraationof membrane collagen in t$e etermination ofprelabor rupture of fetal membranes" T$eformation of t$e rupture initiation site is a functionof a regional variation in collagen cross1lin< ratio"

Tissue ascorbic aci status ma be an important

meiator of t$ese processes"conceptus, pregnanc


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ang 5, Parr S, Macones =, Sammel M8,

Kuivaniemi 5, Tromp =, et al" . functional S9P in t$epromoter of t$e S!RPI95+ gene increases ris< ofpreterm premature rupture of membranes in .frican.mericans **A

Prematurit is more prevalent in .frican .mericans

t$an in !uropean .mericans" e investigate t$econtribution of a functional S9P in t$e promoter oft$e S!RPI95+ gene, enric$e among t$ose of.frican ancestr, to preterm premature rupture ofmembranes (PPROM), t$e leaing ientiCable causeof preterm birt$" S!RPI95+ encoes $eat1s$oc

Table of Refrence

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