Table of ConTenTs - Spine World Summit 2018 - Homesummit.spineworld.org/download/SSAP Program...

1S p i n e S u m m i t A S i A p A c i f i c - H o n g K o n g 2 0 1 5

Table of ConTe nTs

2 Welcome Message

3 organizing Committee

4 General Information

6 supporting organizations

15 biography of Plenary speakers

21 faculty list

29 Paper Presenters

48 Program at a Glance

50 - 68 scientific Program

50 asia Pacific Research Colloquium52 association Colloquium I58 association Colloquium II64 Innovative non-Clinical Colloquium

70 Industrial Partners

72 floor Plan

73 acknowledgement

S e p t e m b e r 2 5 – 2 7 , 2 0 1 5 ▪ A S i A W o r l d - e x p o , H o n g K o n g2

We lCoM e M e ssaGe

It gives us great pleasure to invite you to the spine summit asia Pacific – Hong Kong 2015. The spine summit consists of four simultaneous Colloquiums: association Colloquium I & II, Innovative non-Clinical Colloquium and asia Pacific Research Colloquium. It is the first international spine meeting in history which provides a unique platform for professional working in different sectors of spinal problem management, both clinical and non-clinical, to share their knowledge and experience interactively.

In this 3-day event, over 100 faculties of 19 spinal associations from: north america, europe, australia, China, India, Indonesia, Japan, Korea, Malaysia, Philippines, singapore, Taiwan and Hong Kong; will share with their friends in the region and peers from all over the world on recent surgical advancement and current state of the art in spinal problem management.

In the association Colloquiums, eminent speakers from 19 spinal associations in asia Pacific region will present their best clinical experience in the 24 scientific sessions. our scientific organizing committee has put in extra effort to integrate the lectures and discussion forum into different themes so as to enhance the atmosphere of interactive discussion and experience exchange among the faculties and participants. The main themes are asia Pacific spine expert forum, asia Pacific Minimal Invasive spinal surgery Day, Controversial & Complicated Cases Day, Cross-strait orthopaedic Day, asia Pacific neurosurgery apex and asia Pacific Pain Management Day. We are confident that anyone who joins the association Colloquiums will be rewarded with a broad and in-depth view on the state of the art clinical solution to various spinal problems.

Innovative Colloquium offers a wide coverage of topics in spinal conditions, from pediatric to the elderly, minimally invasive techniques to maximally complex surgeries, spinal trauma to high grade spondylolisthesis, diversity from across the region clinical challenges to basic science advances, just to name a few. on top of that, we have lined up a full range of interesting topics about non-clinical aspects of spinal surgeries, namely practice management, entrepreneurship, implant development, surgical education and branding of a spine surgeon.

Research Colloquium program is rich and varied, including plenary speeches from scoliosis Research society Committees, presentations of past awardees of aospine Research grant from asia Pacific region, and networking sessions throughout the day. The emphasis of the Research Colloquium is to bring together experts and academics from asia Pacific region, and offers an open platform for exchange and consilience of knowledge.

We are sure you will find some topics to fill the gaps in your practice. It is the honor and pleasure to welcoming you in Hong Kong and wish you a pleasant and fruitful stay.

Yong QiuProgram Chairmanasia Pacific ResearchColloquium

Ying-Kei ChanProgram Chairmanassociation Colloquiums

Chung-Chek WongProgram ChairmanInnovative non-ClinicalColloquium

Zhong-Jun LiuProgram ChairmanCross-straitorthopaedic Day

Kang LuProgram Chairmanasia Pacificneurosurgery apex

David SunProgram Chairmanasia PacificPain Management Day


oRGan I z I nG CoM M IT Te e

Asia Pacific ResearchColloquium Association Colloquiums Innovative Non-Clinical

Colloquium

Program Chairman

Yong Qiunanjing Drum Tower Hospital,

nanjing University Medical schoolnanjing, China

Program Chairman

Ying-Kei ChanPamela Youde nethersole eastern Hospital

Hong Kong

Program Chairman

Chung-Chek Wongsarawak General Hospital

Kuching, Malaysia

Cross-StraitOrthopaedic Day

Asia PacificNeurosurgery Apex

Asia Pacific PainManagement Day

Program Chairman

Zhong-Jun LiuPeking University Third Hospital

beijing, China

Program Chairman

Kang Lue-Da Hospital, I-shou University

Kaohsiung, Taiwan

Program Chairman

David SunChinese University of Hong Kong

Hong Kong

SCientifiC Program Planning Committee

organizing CommitteeChung-Chek Wong(Overall Chairman)sarawak General HospitalKuching, Malaysia

ram ChaddhaK.J. somaiya Hospital & Medical CollegeMumbai, India

Ying-Kei ChanPamela Youde nethersole eastern HospitalHong Kong

Xiao-ming Chefudan University Huashan Hospitalshanghai, China

luthfi gatamfatmawati General HospitalJakarta, Indonesia

Kee-Yong Haseoul st. Mary's Hospitalseoul, south Korea

Yong Haibeijing Chaoyang Hospital,Capital Medical University of Chinabeijing, China

Kazutoshi Hidasapporo azabu neurosurgical Hospitalsapporo, Japan

Dong-Sheng Huangsun Yat-sen Memorial Hospital ofsun Yat-sen UniversityGuangzhou, China

tsung-Jen HuangTaipei Medical University HospitalTaipei, Taiwan

Jose manuel ignacioUniversity of the Philippines -Philippine General HospitalManila, Philippines

feng-zeng Jianbeijing Xuanwu Hospitalbeijing, China

Haw-Chou leelife spine & orthopaedics,Mt elizabeth novena Hospitalsingapore

zhong-Jun liuPeking University Third Hospitalbeijing, China

Kang lue-Da Hospital, I-shou UniversityKaohsiung, Taiwan

Seong-Hoon ohnanoori spine & Joint HospitalIncheon, south Korea

Seung-Won ParkChung-ang University Hospitalseoul, south Korea

Bang-Ping Qiannanjing Drum Tower Hospital,nanjing University Medical schoolnanjing, China

Yong Qiunanjing Drum Tower Hospital,nanjing University Medical schoolnanjing, China

ajoy ShettyGanga Medical Centre &Hospitals Pvt. limitedCoimbatore, India

Koon-man Siehalice Ho Miu ling nethersole HospitalHong Kong

David SunChinese University of Hong KongHong Kong

Chung-ting WongTuen Mun HospitalHong Kong

Kam-Kwong WongKwong Wah HospitalHong Kong

Steven WongQueen elizabeth HospitalHong Kong

abdul Halim YusofHospital Universityscience of MalaysiaKota bharu, Malaysia

zhao-min zhengThe first affiliated Hospital ofsun Yat-sen UniversityGuangzhou, China


Ge n e R al I n foR MaT IonDate & Venueseptember 25 – 27, 2015Hall 5 & Hall 7, G/f, asiaWorld-expoHong Kong International airport, lantau, Hong Kong

offiCial languageenglish, Chineseno simultaneous interpretation is provided.

PartiCiPantS iDentifiCationPlease wear your summit name badge for all summit activities. access to conference halls and exhibition area will be denied without a valid name badge.

regiStration informationonsite RegistrationThe registration desks are located at the east lobby of asiaWorld-expo outside Hall 5. Please present the official receipt at the registration desks to collect your summit materials.

opening Hours september 24, 2015 14:00 – 19:00 september 25, 2015 07:30 – 17:30 september 26, 2015 07:30 – 17:30 september 27, 2015 07:30 – 12:00

CertifiCate of attenDanCea Certificate of attendance will be issued to each pre-registered delegate and available for collection at the registration desks on september 26, 2015 afternoon. for on-site registrants, Certificate of attendance will be available on the last day (september 27, 2015) of the summit. no certificate will be issued after the summit.

SCientifiC informationTo speakers and ModeratorsPlease get yourself ready according to the summit schedule.Note: To ensure each session is finished as scheduled, all the speakers are required to finish their presentations with the EXACT allocated time slot.

Presentation Uploadsall invited speakers are requested to upload their presentation files 3 hours prior to their session times inside the faculty lounge. The opening hours of the lounge are as follows:september 25, 2015 07:30 – 17:30september 26, 2015 07:30 – 17:30september 27, 2015 07:30 – 12:00

Considerations for Mac UsersKeynote will noT be accepted as it cannot be played on PC. Please export your presentation as PowerPoint.

eXHiBitionVenue: Hall 5 & Hall 7, asiaWorld-expoexhibition Hours: september 25, 2015 08:20 – 17:30 september 26, 2015 08:20 – 17:30 september 27, 2015 08:20 – 12:00

organizer offiCeVenue: Hall 5, asiaWorld-expo

faCultY loungeVenue: Hall 5, asiaWorld-expo

Coffee BreaKS & lunCHeSRegistered delegates are entitled to coffee breaks and lunches during the summit. Coffee breaks will be served near the exhibition area, while lunches will be served at Hall 2, G/f, asiaWorld-expo on friday and saturday, september 25 – 26, 2015.

imPortant SoCial eventSopening CeremonyDate & Time : september 25, 2015, 09:25 – 09:55Venue : Plenary Hall, Hall 5, asiaWorld-expo

Gala DinnerDate & Time : september 25, 2015, 19:00 – 21:30Venue : sky100, 100/f, International Commerce Centre, 1 austin Road West, Kowloon, Hong Kong

*admission ticket is required.

Ticket can be purchased at onsite registration desk (HKD 800 (UsD 100) per person). limited capacity on a first-come-first-served basis.

internet & CHarging StationVenue: Hall 5 & Hall 7, asiaWorld-expo

Wi-fiasiaWorld-expo provides free Wi-fi. name: aWe free Wi-fi30 minutes per session, maximum of 2 sessions per day.

BeePing DeviCeSPlease switch off mobile phones and beeping devices (or use the vibrate mode) during the summit.

no SmoKing PoliCYasiaWorld-expo is a non-smoking facility. smoking is prohibited.

BanK anD CurrenCYMajor credit cards like Visa, MasterCard and american express can be accepted in most shopping centers and hotels. Major foreign currencies can be exchanged into Hong Kong Dollar at the airport, bank or hotel.

otHer informationall the copyright belongs to ssaP2015. no photographing, audio or video recording allowed without authorization.no advertisements or academic materials allowed without the organizer or committee permission.

PoSt-Summit enQuirYPeak Range Congress and Management serviceUnit 1202, Hillwood Center, 17-19 Hillwood Road,Tsim sha Tsui, Kowloon, Hong KongTel : +852 3520 3221fax : +852 3520 3233email : [email protected]

liaBilitYThe ssaP2015 and the organizer will not assume any responsibility for accidents, losses, damages, cancellations or delays for any causes beyond its reasonable control.

sU P PoRT I nG oRGan I z aT Ion s

6

AOSpine Asia Pacific

aospine is an international community of spine surgeons generating, distributing,

and exchanging knowledge to advance science and the spine care profession through

research, education, and community development. With this collaborative approach,

aospine is advancing spine care worldwide.

education: aospine develops consistent and practical educational programs, strategies,

and tools for worldwide implementation in over 150 educational events, covering all

pathologies, and the different stages in a surgeon’s career. aospine courses, symposia

and academic congresses provide an opportunity for hands-on learning, alongside

constructive discussions with aospine faculty and colleagues in stimulating environments.

Research: aospine Research is driving the transformation of spine care through the

aospine Research network and the aospine Knowledge forums; which are pathology

focused working groups of key opinion leaders aiming to generate knowledge by way of

clinical studies, and publishing of evidence-based recommendations. In the process, they

integrate the latest advances and outcomes of treatment and techniques into aospine’s

education programs.

Community Development: aospine fosters a global community of spine care

professionals who are passionate about furthering science, improving patients’ lives, and

advancing professional careers through the exchange of knowledge and professional

networking. aospine Membership gives you privileged access to this global spine care

community, and benefits aimed to facilitate knowledge access and promote knowledge

exchange.

www.aospine.org

Chinese Association of Spine and Spinal Cord

founded in 1987, CassC is a sub-association registered under Chinese association of

Rehabilitation Medicine (CaRM), a national, voluntary, not-for-profit, professional association of

2.6 million practicing physicians in China.

CassC is formed with the clear purpose of serving the best interests of the public and all

practicing spine surgeons in China. CassC is aiming at continuously improving professional

competence and advance medical knowledge in spine society, protecting the rights and

interests of the practicing spine specialists, and regulating the practice and conduct of Chinese

spine surgeons. CassC has established 10 subspecialty societies such as Cervical Research

Group, spine Tumor Research Group, lumbar Research, and Minimally Invasive spine surgery

Group etc.


Hong Kong Minimal Invasive Spinal Surgery Society

The Hong Kong Minimal Invasive spinal surgery society is formed by a group of

orthopaedic spine surgeons in 2013. The society is dedicated to foster, support and

encourage academic, clinical and research achievement in the process of diagnosis and

treatment related to minimal invasive spinal surgery.

from the pioneer ‘Hong Kong operation’ years ago, the introduction of modern spinal

fixation implants in the late 1980’s, to the recent use of advanced radiological investigation

facilities and navigation tools during surgery, continuous success in the treatment

of spinal problem is obvious. Current trend in using minimal invasive spinal (MIs)

surgical technique to minimize surgical trauma to patients, to hasten patients’ recovery

has energized many spine surgeons to strike for better management strategy for our

patients. However, it is still a reality that MIs surgery has lots of limitations and restricted

indications. Decent and elegant spinal surgical technique, correct mindset and committed

attitude are basic requirements for spine surgeon practicing minimal invasive spinal

surgery.

Through the provision of a platform for exchange of ideas in minimal invasive spinal

surgery and related sciences, the society aims to provide a high standard of training to

young spine surgeon and to carry out all activities appropriate to support the highest

level of performance of minimal invasive spinal surgery. since 2014, two workshops and

symposiums were organized yearly; live animal workshops on spinal dissection and

hemostatic technique, minimal invasive spinal surgery cadaveric workshops, were example

of which. In september 2015, the society collaborates with 18 sister-spine associations in

asia to organize the spine summit asia-Pacific in Hong Kong.

www.hkmisss.org


China

Chinese Congress of Neurological Surgeons

Chinese Congress of neurological surgeons (CCns) is a sub-association under Chinese

Medical Doctor association, CMDa which was established in June 2004. CCns is a

national registered academic neurosurgery organization which is joined by neurosurgeons

and neurosurgery departments from the nation.

The main duty for Chinese neurological society is academic affairs of Chinese

neurosurgery, while the major responsibility of CCns is to deal with issues concerning the

training, education, self-regulation and rights protection of Chinese neurosurgeons.

www.ccnsnet.org

Guangdong Association of Spine and Spinal Cord

The Guangdong association of spine and spinal Cord (GassC) is a regional

multidisciplinary medical association that utilizes education, research and advocacy to

promote the highest quality, ethical, value- and evidence-based spine care for patients.

In this year, GassC reaches the 200th member with cervical spine, lumbar spine, spinal

deformity, minimally invasive, trauma, youth and nursing care 7 groups. The annual

meeting in March every year provides a unique opportunity to learn and gain the latest

information, innovative techniques and procedures, best practices, and new technologies

in spine care. GassC also offers a full spectrum of courses and conferences about spine

and spinal cord throughout the year at regional.

www.gdrehab.com

Guangdong Spinal Surgery Association

Guangdong spine surgery association (GDssa) was founded in March, 2009 with all 230

members now. GDssa has 4 study groups: cervical spine surgery group, lumbar spine

surgery group, spine deformity group and minimal invasive spine surgery group. Current

president of GDssa is Prof Dong-sheng Huang from sun Yat-sen Memorial Hospital of

sun Yat-sen University.


hong Kong

Hong Kong Neurosurgery Spine Interest Group,Hong Kong Neurosurgical Society

The Hong Kong neurosurgical society was formed in 1981 under the leadership of Dr. Hsiang-lai Wen who was our founding president. The society then hosted the asian australasian Congress of neurological surgery 1983 in Hong Kong. In 1996, we have joined the World federation of neurosurgical societies as a member. now we have more than 80 members. We are actively involved in the development of neurosurgery and training of young neurosurgeons in Hong Kong.

www.ns.org.hk

Hong Kong Orthopaedic Association, Spine Chapter

aging is a common health care problem in different populations. Despite aging, our elderly is still very active. They demand for a functional body to maintain pain-free quality life style. The problems secondary to spinal degeneration, osteoportic spinal fracture, adult spinal deformity, spinal canal stenosis, spinal infection and metastatic spinal disease pose great challenge in the manpower resource, technical readiness and financial sustainability of our current healthcare structure.

spinal surgery is one of the specialized fields in orthopaedic surgery. In 2006, the Hong Kong orthopaedic association spine Chapter was formed. It was first the idea of Prof Keith luk that a platform should be formed to gather spine surgeons from different centres for exchange of knowledge and case discussion. Precious and useful advice could be sought from senior spine surgeons at this platform which will benefit patients’ management and training of young spine surgeon. Prof. luk was the first president. The Chapter became mature later under the leadership of Dr. KY fung, Dr. YW Wong and Dr. KK Cheung subsequently.

The Chapter is dedicated to in-depth training of young surgeons interested in spine surgery. an observation week in spine surgery was a good example to provide coordinated attachment opportunities with prospective spine surgeons in different hospitals. They were able to observe and participate in spinal operations with the local spine experts. skill based training opportunities were also regularly provided. In 2013, the spine Chapter organized the 33rd HKoa annual congress with the theme ‘Defeating the aging spine’ successfully. The spine Chapter also coordinates with different sister spine societies, both local and regional, to organize hands on workshop and symposium. The spine Chapter also offers two overseas conference or workshop travelling scholarships each year for members who are not current council office bearer, in order to broaden their horizon and to provide them opportunities to interact with overseas experts.

www.hkoa.org/newHKOA/HKOA_spine_index.html

Hong Kong Pain Society

The Hong Kong Pain society is a multidisciplinary society with representations from different medical specialties and healthcare disciplines. We believe that it is the right of every individual who suffers from pain to have access to appropriate services.

our objectives are to promote exchanges of knowledge and foster collaboration among different specialty Groups (as defined in the articles of association) who are interested in the research and management of pain; to promote training and continued education in the field of pain medicine; to promote public education and knowledge of pain and its management; to promote research in the science, practice and development of techniques and technologies related to pain medicine; and to advise relevant regional agencies and organizations on the advances of pain medicine.

www.hkpainsociety.org


inDia

Association of Spine Surgeons of India

association of spine surgeons of India (assI) was officially launched in september 1985. The aim of assI is to promote scientific spine care, both surgical and non-surgical, in India through the medium of national, regional and local meetings, symposia, CMes and workshops. assI promotes any spine related scientific activity, anywhere in India. assI also facilitates formation of local spine bodies.

over the last 25 years assI has garnered a large number of overseas friends who regularly help assI and enjoy participating in assI events. They have come to love assI and India. assI greatly appreciates their association and contribution.

www.assi.in

Indian Society for Study of Pain

The Indian movement on pain management started in early eighties by senior clinicians namely Dr. Pritam singh, Dr. saini, Dr. bhattacharya, Dr. Pramila Chari, Dr. Yajnik.s., Dr. sushila shah, Dr. akram lal, Dr. Kumar.P., Dr. Pandey.K., Dr. bhatia.M.T., Dr. Rastogi.V., Dr. sharma.K.n. and many others.

The Indian society for study of Pain (IssP) was formed in the year 1984. The first President was Dr. akram lal, secretary was Dr. Rastogi.V. and Treasurer Dr. Kumar.P. The society conducted its first national Conference in the year 1985 at Varanasi. The society’s journal ‘Indian Journal of Pain’ was started in the year 1985 under editorship of Dr. s.Yajnik. The society was acknowledged as Indian chapter of International association for study of Pain (IasP) in the year 1987. IssP entered silver jubilee year of its formation in 2009.

IssP has become a strong body with very sound base formed by a team of dedicated, senior members. It is a matter of pride for all of us that the membership has increased to more than 1700 members and 28 different specialties are part of this organization. Regular academic activities at national & state level exhibit the interest of our members to learn more & more on techniques of pain-relief, training fellowship for junior member adds to this interest. older traditions and myths are slowly but definitely getting out of the people’s mind. Today, with so many advances in the techniques and medicines, we are definitely in a better position to treat almost all types of pain.

www.isspap.org

inDonesia

Indonesian Orthopaedic Association

nine surgeons who were involved in orthopaedic surgery to come together founding the

PaboI (Perkumpulan ahli bedah orthopaedi Indonesia). on september 25, 1969, PaboI

is declared at the biannual General assembly Meeting of the IKabI and was accepted

anonymously.

Congress and forum are organized for communication in hope that orthopaedic

specialists could share their knowledge & experience about orthopaedic world.

The Indonesian orthopaedic association will always try to support and give its best in

supporting the members.

www.indonesia-orthopaedic.org


Japan

Japanese Society of Spinal Surgery

This society was established in 1986. Therefore this year is 30th anniversary for us.

Present president is Prof. Kim Pyo (Dokkyo Medical school).

office locates in osaska Municipal Medical school (neurosurgery).

number of member is 1279 including 1261 regular members and 18 honored members (as

of June 2015).

among them board spinal surgeon is 99 and certified spinal surgeon is 384. and spinal

training institute is 36.

square.umin.ac.jp/jsss-hp

Malaysia

Malaysia Spine Society

It is officially registered on 13th october 2006 and inaugural scientific meeting of the

society was held at Mariott Putrajaya 9-10th December 2006 with the theme “spine

Trauma & non-fusion Techniques”. The members are confined to trained spine surgeons,

and up to 2015 Mss have 75 registered members. Mss hold annual general meeting

and the office-bearers is elected held biennially. The current president is Dr Dato Ks.

sivananthan (2015-2017). Mss since then was given due recognition as a group of experts

in issues dealing with spine surgery. Representatives from the society were invited as

examiners for spine fellowship program organized by Ministry of Health and Mss also

involved in advocacy issues helping formulating national policies and fee scheduling for

private practices. apart from regular regional spine circle meeting Mss had organized

international conferences such as Mss - sRs International spine Congress 2011 on

8-10 Dec 2011 and International Minimally Invasive spine (MIs) Congress on 20-22 March

2014 both held in Kuala lumpur Malaysia. The forthcoming event is asIan spine summit

forum on 24-25 oct 2015 at Ipoh Malaysia.

www.mss.org.my


philippines

Philippine Spine SocietyA Venue for Learning

In 1995, a group of orthopaedic and neurosurgeons with a special interest in the field of spinal surgery, after having felt the need for an appropriate educational setting that will maintain the highest level of professional standards in the practice of the specialty, formed the Philippine spine society (Pss). This need witnessed the birth of one of the most active specialty societies in the country today.

Its objectives were:

• Toserveasamediumfortheexchangeofideasandsharingofexperiencesamongstitsmembers

• Tofosterharmoniousrelationshipsandcamaraderieamongstitsmembers• Toenhancetheknowledgeandsurgicalskillsofallspinesurgeons throughscientific

activities, for the benefit of patients• Topromotetheadvancementofspinalsurgeryinthecountry

The Pss is the foremost organization in the country today catering to the advancement and propagation of spine care. The society actively provides and organizes venues for continuing medical education and research. The society likewise actively establishes linkages with local and international spine organizations.

all the efforts of the society are geared towards the proper care of patients in the country afflicted with various ailments of the spine.

www.philortho.org/philippine-spine-society

south Korea

Korean Society of Spine SurgeryThe Korean society of spine surgery is an organization that provides a forum for the exchange of ideas between health care professionals so as to promote research in spinal surgery.

The society was founded in 1984 and has since become the longest-running organization specializing in the spine in Korea. It holds an annual meeting twice a year in spring and autumn and provides instructional courses for surgeons and related professionals on a yearly basis.

The society endeavors to create optimal care for patients with spinal diseases through education for both professionals and patients as well as the support of research by its members in the name of advancing the academic field of spinal surgery.

www.spine.or.kr

Korean Spinal Neurosurgery SocietyKorean spinal neurosurgery society is the largest and the most active society in the Kns. The society was established as the Korean spinal neurosurgery Research society, the third research society of the Korean neurosurgical society, through the general meeting of the Korean spinal neurosurgery Research society and the first academic meeting on December 19, 1987. Thanks to the improvement of the research society, it was renamed as the Korean spinal neurosurgery society on December 17, 1999 after approval by the Korean neurosurgical society.

www.neurospine.or.kr


taiwan

Taiwan Neurosurgical Spine Society

on March 11, 2002, in an effort to integrate the country engaged in spinal surgery

neurosurgeon, under the advanced guidance of founding President, Chun-Yi Huang, MD,

PHD, establish the Taiwan neurosurgical spine society. The goal is to unite the country in spinal

surgery neurosurgeon and enhance the standard of domestic neural spine surgery care.

service Items:

1. Promoting research and development in neurosurgical spine

2. Holding academic lectures and seminars

3. Participate in international conferences and events of medicine and promote the

exchange of relevant academic groups

4. Journal of nervous and spine medicine concerning the publication of books and

periodicals

5. Culture exchange of medical experience to assist Member and neurological spine

surgeons of training and continuing education

6. organizing surgical spinal nerve-related medical activities

www.tnss.org.tw

Taiwan Spine Society

The Taiwan spine society was founded in 1992, in Taipei, Taiwan. Prof. Geng-Hsiong You

served as the founding president and all the experts in the field of spinal surgery did their

endeavors to start the academic society.

The objectives of the Taiwan spine society include:

- To promote the researches and development in spinal diseases and disorders

- To improve the academic exchange and communication regarding spinal diseases and

disorders domestically and abroad

- To form an educational platform dedicated to the exchange of ideas and dissemination

of scientific and clinical knowledge related to spinal diseases and disorders

In recognition of the responsibility of the society, we have been holding many academic

meetings annually, including an annual conference in spring, an academic symposium in

summer, a combined conference with the Taiwan orthopaedic association in autumn, and

an instructional course for young fellows and spine surgeons in winter.

With all the dedications to the society from the past and present president Prof. Tsung-Jen

Huang, and staffs, Taiwan spine society has become a spectacular organization standing firm

to pursue the professionalism of spinal diseases and disorders.

www.twss.org.tw


b IoGR aP HY of P le naRY sP e aK e R s

CanaDa

hubert labelle Sainte-Justine University HospitalMontreal, Canada

Hubert labelle received an M.D. in 1976 and completed a residency in orthopaedics at University of Montreal in 1981, followed by a 2-year fellowship in paediatric orthopaedics at sainte-Justine University Hospital in Montreal, Rancho los amigos Hospital in California and the a.I. Du Pont Institute in Delaware. since 1982, he has been appointed in the department of surgery at University of Montreal and at ste-Justine University Hospital (sJUH) where he is currently Professor of surgery and Titular of the Motion sciences Research Chair at University of Montreal. His clinical work is focused on the evaluation and treatment of spinal deformities in children and adolescents. He was Chief of orthopaedics at sJUH from 1993 to 2011, and is currently the Head of orthopedics at University of Montreal, the Head of the Musculo-skeletal axis of excellence at sJUH, a multi-institutional and inter-disciplinary team, and the Director of the 3-D scoliosis laboratory at sJUH. His research interests are concentrated on the 3-D evaluation and treatment of spinal deformities, with a particular emphasis on computer assisted surgery, 3-D design and evaluation of braces for the treatment of idiopathic scoliosis, 3-D evaluation and simulation of surgery for scoliotic deformities, and sagittal analysis of spondylolisthesis. Dr labelle has participated in more than 50 invited professorships and lectureships. In addition, he has over 300 peer-reviewed articles and more than 200 book chapters published.

China

yong QiuNanjing Drum Tower Hospital, Nanjing University Medical SchoolNanjing, China

Dr. Yong Qiu, Professor and Director of orthopaedics, nanjing Drum Tower Hospital, nanjing University Medical school. He is now the president of Chinese scoliosis research society. His team has successfully operated on more than 8,000 scoliosis patients during last 17 years, who came from all over the country and from the southeast of asia. His spine unit consists 142 beds and is one of the world-leading scoliosis centers. He also focused on the research of etiology and pathology of scoliosis. since 2005, he has published more than 100 sCI articles, participated in compiling 41 professional books. He has presented in many international conferences such as sRs, IMasT, IRssD, euro-spine and ao-spine. because of his world renowned contribution to the treatment of spinal deformity, he has won great international reputation in the area of scoliosis treatment and research and was horned as the editorship of european spine Journal, spine Journal and bMC Musculoskeletal.


hong Kong

Keith lukQueen Mary Hospital, University of Hong KongHong Kong

Professor luk graduated from the University of Hong Kong in 1977 and at present holds the Tam sai Kit Chair in spine surgery at the Department of orthopedics and Traumatology, the University of Hong Kong.

Professor luk was Head of the Department from 2003-2012. He was President of the Hong Kong orthopaedic association from 1993-1994, President of the Hong Kong College of orthopaedic surgeons in 1999-2000. at present he is President of the sICoT and second Vice President of the Issls.

Professor luk has written over 330 refereed articles, 27 book chapters and holds 15 patents. In 2007 he published in the lancet the first successful series of intervertebral disc transplantation in the human.

netherlanDs

Bart KoesDepartment of General Practice, ErasmusMCRotterdam, Netherlands

Professor bart Koes is the research director of the Department of General Practice, erasmusMC since 1999 and is currently heading a department of 40 researchers. about half of the projects at the department are large scale randomised clinical trials. The other studies include observational (cohort) studies and systematic reviews and meta-analysis. Most studies concern musculoskeletal disorders in primary care. bart Koes published widely (about 470 publications listed in Pubmed) in the area of musculoskeletal disorders in primary care. He is one of the most published researchers in the field of low back pain, currently ranked third in the world.


uniteD states

Jahangir asgharNicklaus Children's HospitalMiami, United States

Dr. asghar is an attending spine surgeon with the Department of orthopaedics at nicklaus Children’s Hospital in Miami with his partner Harry shufflebarger. Prior to nCH he spent 4 years at the shriners Hospital for Children, Philadelphia, where he was an attending pediatric spine surgeon. He completed a fellowship in pediatric spine surgery at the Philadelphia shriners Hospital for Children. He has also passed his written national orthopedic board examination.

Dr. asghar is a member of the american academy of orthopaedic surgery, the scoliosis Research society, society of Military orthopedic surgeons, and the north american spine society. He is one of the designated founding members of the society for Minimally Invasive spine surgery and has published and presented extensively on the treatment of complex pediatric spinal deformities.

sigurd BervenUniversity of CaliforniaSan Francisco, United States

Dr. sigurd H. berven has a strong clinical interest in spinal disorders of children and adults. He is interested in pediatric and adult deformity, degenerative conditions of the spine, spinal tumors and spinal trauma. His research interests include assessment of clinical outcomes of surgery, and minimally invasive techniques in spine surgery. berven also is studying cellular and molecular techniques for the biological regeneration of components of the spine including the intervertebral disc. berven has been an invited speaker at national and international conferences, speaking on topics including measurement of outcomes in spine surgery, evaluation and management of spinal disorders, and advanced techniques in spine surgery.

He is a graduate of the Harvard Combined orthopedic Residency. after completing his residency, he had further clinical training in spine surgery as a clinical fellow at UCsf and in pediatric orthopedic surgery as the chief resident at boston Children's Hospital. berven studied human biology as an undergraduate at stanford University. He was a graduate student at oxford University in philosophy, politics and economics. He received his medical degree from Harvard Medical school.


lawrence haber University of Mississippi, Medical CenterMississippi, United States

lawrence Haber MD did his orthopaedic training at the Medical College of Virginia in 1998 and completed a Pediatric orthopaedic fellowship at Vanderbilt University. He practiced as an assistant professor at Case Western Reserve University in Cleveland ohio for six years and then in 2004 took a position at the University of Mississippi Medical Center, where he rose to professor and served as chief of pediatric orthopaedic surgery for over 10 years. He continues in Mississippi with a very busy pediatric spine practice, while also fulfilling multiple leadership roles for the hospital. Most of his research interests are clinical and involve scoliosis surgery. He has done many national and International presentations and publications. Dr. Haber is currently Continuing Medical education (CMe) Chairman for the scoliosis research society and recently served as awards and scholarships Chair. In addition, he has held multiple volunteer positions with sRs, Pediatric orthopaedic society of north america (Posna) and american academy of orthopaedic surgeons. Dr. Haber is very active in his community, passionate about his family and enjoys playing guitar, golf and fishing.

hassan serhanDePuy Synthes - SpineRaynham, United States

Hassan serhan is a Distinguished engineering fellow at DePuy synthes - spine and a Prestige adjunct Professor at the bioengineering Department at University of Toledo. Prior to his employment with acroMed 1995 which was acquired by J&J in 1999, Hassan was a research assistant professor at both the neurosurgery and orthopedic surgery at the state University of new York at buffalo where he received his Ph.D. in Mechanical engineering.

Hassan has been the recipient of many awards including, american society for Testing and Materials (asTM) Moses award, scoliosis Research society John Moe’s award, nominated for the sRs Whitecloud award, received King Khalid Gold and silver Medals, Who’s Who in Medicine, Who’s Who among the students in american University and Colleges. Hassan is the co-founder and treasurer of the International Musculoskeletal society (I.M.s.) formally known as society for Progress and Innovation for the near east (s.P.I.n.e.). He chaired the cadaveric workshops for the past seven year for the I.M.s. annual meetings.

Hassan has published more than 45 peer reviewed journal articles, 8 book chapters and more than 170 abstracts. He is also a reviewer for several national and international peer reviewed journals and has been invited as a guest lecturer by many universities and research institutes worldwide as a visiting professor and gave more than 110 invited lectures & grand rounds. Hassan is a prolific inventor with more than 100 patents and patent applications.


rajiv sethiVirginia Mason Medical Center, University of WashingtonSeattle, United States

Dr. sethi currently serves as the Director of Complex spinal surgery and the Chairman of the neuroscience Institute at Virginia Mason Medical Center and serves as clinical associate professor at the University of Washington in seattle, Washington, Usa. Dr. sethi attended Harvard Medical school and did his orthopaedic and complex spine training at the Massachusetts General Hospital / Harvard orthopaedic Program in boston and the University of California at san francisco.

Dr. sethi is actively involved in the leadership of the scoliosis Research society including having served on the adult deformity, research grant, IMasT, worldwide conference and safety committees. His research around team approaches in spinal deformity surgery was nominated for the prestigious Whitecloud award by the sRs in 2012. Dr. sethi has presented multiple peer-reviewed papers on the importance of team and multidisciplinary strategies to mitigate risk and increase patient safety in complex spinal surgery and his work has led to a number of invited professorships in the Us and abroad.

alexander VaccaroThomas Jefferson UniversityPhiladelphia, United States

Dr. Vaccaro graduated summa Cum laude from boston College in 1983 with a b.s. in biology. He received his M.D. degree from Georgetown University school of Medicine where he was promoted with “Distinction”. He earned membership in the alpha omega alpha (aoa) Honor society and graduated with honors in 1987. He completed a year of surgical Internship at Cedars-sinai Medical Center in los angeles, Ca and his orthopaedic surgery Residency was at Thomas Jefferson University where he graduated in 1992. Dr. Vaccaro completed a spine fellowship at the University of san Diego, Ca. He earned a PhD in 2007 in the field of spinal Trauma. Dr. Vaccaro is currently pursuing a Mba at the fox school of business at Temple University in Philadelphia.

Dr. Vaccaro is the Richard H. Rothman Professor and Chairman of orthopaedic surgery and Professor of neurosurgery at the sidney Kimmel Medical College at Thomas Jefferson University in Philadelphia, Pennsylvania. He was the recipient of the leon Wiltse award given for excellence in leadership and clinical research for spine care by the north american spine society (nass) and is the past President of the american spinal Injury association and current President of the association for Collaborative spine Research.

He has over 600 peer reviewed and 190 non-peer reviewed publications. He has published over 300 book chapters and is the editor of over 46 textbooks and co-editor of oKU-spine I and editor of oKU-8. Dr. Vaccaro is the Co-Director of the Regional spinal Cord Injury Center of the Delaware Valley and Co-Chief of spine surgery and the spine fellowship program at the sidney Kimmel Medical College at Thomas Jefferson University where he instructs current fellows and residents in the diagnosis and treatment of various spinal problems and disorders.


faC U lT Y l I sT

CANADA

Hubert LabelleSainte-Justine University HospitalMontreal, Canada

FrANCe

Richard EmeryFrance

Philippe RoussoulySMAIOLyon, France

NeTHerlANDS

Bart KoesDepartment of General Practice, ErasmusMCRotterdam, Netherlands

Maarten SpruitSt MaartenskliniekNijmegen, Netherlands

OMAN

Venugopal MenonKhoula HospitalMuscat, Oman

international

UNITeD STATeS

Jahangir AsgharNicklaus Children's HospitalMiami, United States

Sigurd BervenUniversity of CaliforniaSan Francisco, United States

Christopher CainUniversity of Colorado DenverColorado, United States

Lawrence HaberUniversity of Mississippi Medical CenterMississippi, United States

Hassan SerhanDePuy Synthes - SpineRaynham, United States

Rajiv SethiVirginia Mason Medical Center,University of WashingtonSeattle, United States

Alexander VaccaroThomas Jefferson UniversityPhiladelphia, United States


AUSTrAlIA

Bryan AshmanCanberra HospitalCanberra, Australia

Eleanor ClausenThe Medical PrecinctAdelaide, Australia

Julie FallonThe Medical PrecinctAdelaide, Australia

CHINA

Xiao-Ming CheFudan University Huashan HospitalShanghai, China

Chun-Mei ChenFujian Union Hospital,Fujian Medical UniversityFuzhou, China

Jian-Ting ChenNanfang Hospital,Southern Medical UniversityGuangzhou, China

Liang ChenThe First Affiliated Hospital ofSoochow UniversitySuzhou, China

Zan ChenCapital Medical University,Xuan Wu HospitalBeijing, China

regional

Zhe-Hao DaiThe Second Xiangya Hospital of CentralSouth UniversityHunan, China

Hai-Long FengSichuang Provincial People's HospitalSichun, China

Yong HaiBeijing Chaoyang Hospital,Capital Medical University of ChinaBeijing, China

Da-Geng HuangHonghui Hospital,Xi’an Jiaotong University HealthScience CenterXi'an, China

Dong-Sheng HuangSun Yat-sen Memorial Hospital ofSun Yat-sen UniversityGuangzhou, China

Jian LiThe Third Affiliated Hospital ofGuangzhou Medical UniversityGuangzhou, China

Michael LiMedtronic Kanghui Medical Innovation Co., Ltd.Changzhou, China

Wei-Shi LiPeking University Third HospitalBeijing, China


An-Jing LiangSun Yat-sen Memorial Hospital ofSun Yat-sen UniversityGuangzhou, China

Guo-Yan LiangGuangdong General HospitalGuangzhou, China

Hui LiuThe First Affiliated Hospital ofSun Yat-sen UniversityGuangzhou, China

Shao-Yu LiuThe First Affiliated Hospital ofSun Yat-sen UniversityGuangzhou, China

Zhong-Jun LiuPeking University Third HospitalBeijing, China

Yan PengSun Yat-sen Memorial Hospital ofSun Yat-sen UniversityGuangzhou, China

Bang-Ping QianNanjing Drum Tower Hospital,Nanjing University Medical School Nanjing, China

Yong QiuNanjing Drum Tower Hospital,Nanjing University Medical School Nanjing, China

Li-Min RongThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou, China

Jian-Xiong ShenPeking Union Medical College HospitalBeijing, China

Pei-Qiang SuThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou, China

Huan WangShengjing Hospital, China Medical UniversityShenyang, China

Zeng-Hui WuGuangzhou General Hospital of Guangzhou Military CommandGuangzhou, China

Guo-Yong YinThe First Affiliated Hospital of Nanjing Medical University, JiangsuNanjing, China

Zhao-Min ZhengThe First Affiliated Hospital ofSun Yat-sen UniversityGuangzhou, China

HONG KONG

Ying-Kei ChanPamela Youde Nethersole Eastern HospitalHong Kong

Hung-Tsan ChowPrivate Orthopaedic Spine SurgeonHong Kong

Kwan-Ngai HungUniversity of Hong KongHong Kong


Wai-Man HungHong Kong Neurosurgery CentreHong Kong

Joshua KoPamela Youde Nethersole Eastern HospitalHong Kong

Joseph MK LamBrain & Spine Consultant ClinicHong Kong

Clarence LeungMIS Center,Hong Kong Adventist HospitalHong Kong

Carina LiTuen Mun & Pok Oi HospitalsHong Kong

Keith LukQueen Mary Hospital,University of Hong KongHong Kong

Daniel NgPrivate NeurosurgeonHong Kong

Dino SamartzisUniversity of Hong KongHong Kong

Koon-Man SiehAlice Ho Miu Ling Nethersole HospitalHong Kong

David SunChinese University of Hong KongHong Kong

Lun-Kit SunHong Kong Orthopaedic & Spine CentreHong Kong

Chung-Ting WongTuen Mun HospitalHong Kong

Kam-Kwong WongKwong Wah HospitalHong Kong

Raymond WongUnited Christian HospitalHong Kong

Steven WongQueen Elizabeth HospitalHong Kong

INDIA

Ram ChaddhaK.J. Somaiya Hospital & Medical CollegeMumbai, India

Rupinder ChahalSir Ganga Ram HospitalNew Delhi, India


Muralidhar JoshiKamineni HospitalsHyderabad, India

Madhuri LokapurJehangir HospitalPune, India

Raghava MulukutlaUDAI OMNI Hospital for Advanced Orthopaedics & TraumaHyderabad, India

Kanchan SardaIndian Spinal Injuries CentreNew Delhi, India

Ajoy ShettyGanga Medical Centre & HospitalsPvt. LimitedCoimbatore, India

Bidre UpendraBhagwan Mahaveer Jain HospitalBangalore, India

INDONeSIA

Luthfi GatamFatmawati General HospitalJakarta, Indonesia

Charles SimanjuntakUniversity of JambiJambi, Indonesia

JAPAN

Kazutoshi HidaSapporo Azabu Neurosurgical HospitalSapporo, Japan

Mamoru KawakamiWakayama Medical University,Kihoku HospitalIto-gun, Japan

Masayuki MiyagiKitasato University, School of MedicineKanagawa, Japan

Toshiyuki TakahashiFujieda Heisei Memorial HospitalFujieda, Japan

Toshihiro TakamiOsaka City UniversityOsaka, Japan

Satoshi YamaguchiHiroshima UniversityHiroshima, Japan

Kentaro YamaneNational Hospital Organization Fukuyama Medical CenterHiroshima, Japan

MAlAySIA

Mohd Hisam Muhamad AriffinUniversity Kebangssan MalaysiaMedical CentreKuala Lumpur, Malaysia

Lim-Beng SawSunway Medical CentreKuala Lumpur, Malaysia


Chung-Chek WongSarawak General HospitalKuching, Malaysia

Abdul Halim YusofHospital UniversityScience of MalaysiaKota Bharu, Malaysia

PHIlIPPINeS

Jose Joefrey ArbatinChong Hua HospitalCebu, Philippines

Dave Anthony DizonUniversity of the Philippines -Philippine General HospitalManila, Philippines

Jose Manuel IgnacioUniversity of the Philippines -Philippine General HospitalManila, Philippines

Ronald TangenteDavao Doctors HospitalDavao, Philippines

SINGAPOre

Brenda BenceBDA International Group Pte LtdSingapore

Naresh KumarNational University HospitalSingapore

Haw-Chou LeeLife Spine & Orthopaedics,Mt Elizabeth Novena HospitalSingapore

SOUTH KOreA

Tack-Geun ChoHallym University Kangnam Sacred Heart Hospital Seoul, South Korea

Kee-Yong HaSeoul St. Mary's HospitalSeoul, South Korea

Keung-Nyun KimSeverance Hospital, Yonsei UniversitySeoul, South Korea

Seok-Woo KimHallym University Sacred Heart HospitalAnyang, South Korea

Jung-Kil LeeChonnam National University HospitalGwangju, South Korea

Kyu-Yeol LeeDong-A University HospitalBusan, South Korea

Seong-Hoon OhNanoori Spine & Joint HospitalIncheon, South Korea

Seung-Won ParkChung-Ang University HospitalSeoul, South Korea


Kyeong-Sik RyuCatholic University of Korea,Seoul St. Mary's HospitalSeoul, South Korea

Jin S. YeomSeoul National University Bundang HospitalSungnam, South Korea

TAIwAN

Chih-Ju ChangCathay General HospitalTaipei, Taiwan

Ing-Ho ChenBuddhist Tzu Chi General hospitalHualien, Taiwan

Tzu-Yung ChenKuang Tien General Hospital - ShaluShalu, Taiwan

Yung-Hsiao ChiangTaipei Medical University HospitalTaipei, Taiwan

Wen-Hsiang ChouChen-Hsin General HospitalTaipei, Taiwan

Chia-Hsiao KuoTungs' Taichung MetroHarbor HospitalTaichung, Taiwan

Yen-Yao LiChang Gung Memorial HospitalChiayi, Taiwan

Kang LuE-Da Hospital, I-Shou UniversityKaohsiung, Taiwan

Jwo-Luen PaoFar-Eastern Memorial HospitalTaipei, Taiwan

Shih-Tien Wang National Yang Ming University,Taipei Veterans General HospitalTaipei, Taiwan

Tze-Hong WongNational Taiwan University Hospital -Hsin-Chu BranchHsin Chu, Taiwan

Jau-Ching WuTaipei Veterans General HospitalTaipei, Taiwan

Meng-Huang WuTaipei Medical University HospitalTaipei, Taiwan

Shu-Hua Yang National Taiwan University HospitalTaipei, Taiwan


PaP e R P R e se nTe R s

rupinder ChahalSir Ganga Ram HospitalNew Delhi, India

abstract

imPaCt of traneXamiC aCiD on reD BlooD CelltranSfuSion in SPinal SurgerY

Principal investigator: Dr. rupinder Pal Singh ChahalCo-investigators: Dr. Shankar Acharya, Dr. Kashmiri lal Kalra

Dept. of Spine Surgery, Sir Ganga Ram Hospital, New Delhi, India

Purpose: spinal surgery may be associated with substantial blood loss which often requires

erythrocyte transfusion. Transfusion of RbCs is not free of adverse events and has been associated with increased risks of infection, and globally higher morbidity and mortality. Different techniques have been used to reduce perioperative blood losses and related transfusions. Tranexamic acid has been used successfully in cardiac, joint replacement and hepatic surgery. However, only a few studies have reported on the use of antifibrinolytic drugs in spinal surgery. This study is designed to assess the efficacy and safety of tranexamic acid in spinal surgery for the reduction of RbC transfusion.This research proposal will test the following hypotheses:1. Tranexamic acid reduces the estimated perioperative blood loss in adult patients undergoing

elective spinal fusion.2. Tranexamic acid reduces the need for blood transfusion in adult patients undergoing elective

spinal fusion.study Design: Prospective randomized double blind placebo controlled

Material and methods: a total of 50 patients, randomized 25 each to receive drug and

placebo will be studied. The administration of tranexamic acid / placebo will start following the induction of general anesthesia. a bolus dose will be given intravenously over 30 minutes followed by a continuous infusion administered up to 6 hours postoperatively. Tranexamic acid bolus dose of 30 mg/kg followed by a continuous intravenous infusion of 16 mg/kg/h administered up to 6 hours after surgery. for placebo bolus dose of normal saline (naCl 0.9%) of equivalent volume followed by a continuous intravenous infusion of naCl 0.9% administered up to 6 hours after surgery. Drugs used for anesthesia and postoperative analgesia will be left to the discretion of the attending anesthesiologist. The administration of fluids (crystalloids, colloids and blood products) will be recorded. The transfusion trigger will be < 8 g/dl during surgery if the situation is stable. Transfusion may be initiated according to the attending anesthesiologist if the situation is unstable. In the case of massive bleeding, transfusion will follow our standard institutional protocol. The presence of micro vascular bleeding at the surgical site will be assessed by the surgeon. The transfusion trigger during the postoperative period will be < 8 g/dl. blood losses and the need for transfusion will be recorded from the moment of surgery up to 72 hours postoperatively.

before surgery hemoglobin and coagulogram values will be recorded. During surgery, the patient's coagulation status will be assessed using a thromboelastograph (TeG). TeG testing will be performed at the induction of anesthesia and every 2 hours throughout surgery. an additional blood sample for TeG analysis will be collected at the end of surgery if the previous


test was performed more than an hour before the end of surgery. after surgery laboratory testing for hemoglobin, coagulogram, fibrinogen and d-dimer will be performed in the recovery room. Hemoglobin will also be measured on postoperative days 1, 2 and 3. blood samples to assess cardiac troponin levels will be collected on postoperative days 1 and 2. The presence of adverse events during the course of the hospital stay will be noted. at 30 days, patients will be contacted by phone to detect any other adverse events.

outcome Measures for this Clinical TrialPrimary Measures• Percentageofpatienttransfusions:Fromsurgeryuntil72hourspostoperatively• Numberofredbloodcelltransfusions:TimeFrame:Fromsurgeryuntil72hours

postoperativelysecondary Measures• Measuredbloodlosses,Morbidity,Mortality,Lengthofstayinthehospital

Criteria for Participation in this Clinical Trialafter clearance from the hospital ethic committee, patients were counselled and consented to participate in this trial.Inclusion Criteria:• Patientsaged18to85years• Patientsundergoingposteriorspinalsurgerywithexpectedsignificantbloodlossexclusion Criteria:• Allergytotranexamicacid• Epilepsy• Minimallyinvasivesurgery• Unwillingnesstoreceivebloodtransfusion• Knowncoagulopathy/hepaticdisease• Previousthromboembolicevents• Pregnancy• Renalimpairment• Colourblindness

results: There were two groups one with drug and other with placebo. statistical analysis

showed no significant differences between the 2 study groups with regard to age, sex, weight, preoperative hemoglobin, and hematocrite levels, type of surgery, as well as operative time. In contrast, patients who received Ta had 40% reduction of blood loss and required 80% less blood transfusion than patients who received placebo. The hospital stay was shorter in the tranexamic acid group, but it did not achieve statistical significance. There were no complications related to the use of large doses of tranexamic acid in this study as measured by physical examination, fibrinogen, d-dimer and troponine levels.

Conclusion: Prophylactic use of large doses of tranexamic acid provides an effective,

safe, and cheap method for reducing blood loss during and after spinal operations. The beneficial effects are believed to probably be due to inhibition of local fibrinolytic activity in the surgical field. Tranexamic acid has no significant effects on peripheral fibrinolysis or other coagulation variables. Hence, tranexamic acid may help in reducing not only transfusion related complications but also operative expenses. That tranexamic acid safely reduces the need for blood transfusion in surgery has important health and economic implications in high, middle, and low income countries.


tack-geun ChoHallym University Kangnam Sacred Heart HospitalSeoul, South Korea

abstract

CHroniC ParaSPinal muSCle inJurY moDel in rat

Objective: Paraspinal muscles can be degenerated by both spontaneous atrophy and iatrogenic decrease of muscular blood supply, which are chronic processes. The studies for the pathophysiology of the recovery of muscles with chronic damage must need an animal model of chronic irreversible muscle damage. However there had been no proper animal model developed for chronic muscle damage. The purpose of this study is to establish an animal model of chronic paraspinal muscle injury in rat.

Material and methods: 54 sprague-Dawley male rats were divided into experimental group (n=30), sham (n=15), and normal group (n=9). Incision was done from T8 to l2 and paraspinal muscles were detached from spine and tied at each level. The paraspinal muscles exposed and untied after 2 weeks of surgery. sham operation was done by paravertebral muscles dissection at the same levels and wound closure without tying. Kyphotic index and thoracolumbar Cobb’s angle were measured at preoperative, 2, 4, 8, and 12 weeks after the first surgery for all the 3 groups. The rats were sacrificed at 4, 8, and 12 weeks after the first operation, and performed histological examinations.

results: The kyphotic index decreased and Cobb’s angle increased significantly at 4 weeks in the experimental group comparing to those of the sham group (p<0.05), but there was no significant difference between those of sham and normal groups. In histological examinations, necrosis and fibrosis were observed clearly and persisted until 12 weeks after surgery. There was also presence of regenerated muscle cells which nucleus is at the center of cytoplasm, centronucleated myofibers. There were some fibrosis and small number of centronucleated myofibers without necrosis in the sham group.

Conclusion: our chronic paraspinal muscles injury model seems to show necrosis and fibrosis in the muscles for a long time, which might be useful to study pathophysiology or regenerative treatments of chronic non-traumatic muscle damage or degeneration.

Key words: animal model, Paraspinal muscle, Chronic injury, Kyphosis


Zhe-hao DaiThe Second Xiangya Hospital of Central South UniversityHunan, China

abstract

SColioSiS moDel in an aSYmmetriC forCe BiPeDal rat anD Bone miCro-arCHiteCture aDaPtationS of verteBrae

Zhe-Hao Dai1, Guo-Hua lv1, Bing wang1, yi-Jun Kang1, lin-yun lu1,2

1 Department of Spine Surgery,The Second Xiangya Hospital of Central South University, China

2 Department of Orthopedics, The Fifth Hospital of Xiamen, Xiamen

Purpose: To evaluate the difference of the bone micro-architecture between the concave side and the convex side in tether-bipedal rat scoliosis model, and analyze the relationship between the bone micro-architecture of vertebrae and scoliosis.

Material and methods: 40 sD rats were divided into 2 groups: bipedal rat group and tether-bipedal rat group. bipedal rat model was made by amputation of the forelimbs and tail. The left inferior angle of scapula to the ipslateral bony pelvis was sutured in tether-bipedal rat group after amputation of the forelimbs and tail. after 8 weeks, the tethering suture was released. spinal deformity was documented with serial X-ray examinations at an interval of 4 weeks. after sacrifice, the rotation angle of apical vertebrae was measured and Micro CT was used to analyze the bone micro-architecture.

results: all rats in tether-bipedal rat group developed scoliosis and no scoliosis was detected in bipedal rat group. The average initial Cobb angle was 0° immediately after the operation and progressed to 23.5°±4.2° on average after 4 weeks, 40.6°±9.4° on average after 8 weeks, 37.8°±9.9°on average after 12 weeks. The rotation angle of apical vertebral was 3.5°-9.0° on the average of 6.0°. There was no difference in vbMD, bV/TV, Tb.Th, Tb.n, Tb.sp between both sides of vertebrae in bipedal rat group. The vbMD, bV/TV and Tb.Th on the concave side significantly increased, and Tb.sp significantly decreased compared with that on the convex side in tether-bipedal rat group. The vbMD, bV/TV and Tb.Th on the concave side and vbMD on the convex side in tether-bipedal rat group significantly increased compared with the bipedal rat group.

Conclusion: Use of suturing the left inferior angle of scapula to the ipslateral bony pelvis in bipedal rats can establish the scoliosis model successfully. bone micro-architecture on the concave side of apical vertebrae was remodeling, which can help to prevent the progress of scoliosis.


Da-geng huangHonghui Hospital, Xi’an Jiaotong University Health Science CenterXi’an, China

abstract

riSK of atlantooCCiPital Joint inJurY During C1 PeDiCle SCreW inSertion: a Ct-BaSeD morPHologY StuDY of atlaS

Da-Geng Huang, M.D., Ding-Jun Hao, M.D.Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University Health Science Center

Background: C1 pedicle screw technique is increasingly popular for atlantoaxial screw-rod fixation. Many authors have reported anatomic studies for C1 pedicle screw insertion. Most of them focused on whether the pedicle screw would injury transverse foramen, vertebral groove and spinal dura. no study evaluates the risk of atlantooccipital joint injury during C1 pedicle screw insertion yet.

Purpose: To evaluate the risk of atlantooccipital joint injury when inserting C1 pedicle screw and analyse the related anatomic factors.

Study design: a CT-based morphology study.

Material and methods: one hundred thin-cut upper cervical spine computed tomography (CT) scans which met our inclusion criteria were acquired. The sagittal plane of the planned C1 pedicle screw trajectory was reconstructed. each sagittal plane was considered as a single unit. and then a 3.5-mm-diameter cylinder was draw to simulate a 3.5-mm-diameter pedicle screw inserting into atlas on each sagittal plane. atlantooccipital joint penetration by the pedicle screw was defined as atlantooccipital joint injury. Those sagittal planes with atlantooccipital joint injury were carefully studied and the morphology of the atlas was observed and analysed.

results: Two hundred study units were obtained from one hundred upper cervical spine CT scans. Virtual C1 pedicle screw insertion showed that atlantooccipital joint injury occurred in thirty-two units (16%) with bilaterally in eleven patients and unilaterally in ten patients. over-concave superior articular facet of atlas, high junction of C1 pedicle and C1 lateral mass, and over-cephalad incline of C1 pedicle were observed in units with atlantooccipital joint injury.

Conclusion: atlantooccipital joint injury may occur in partial patients during C1 pedicle screw insertion. over-concave superior articular facet of atlas, high junction of C1 pedicle and C1 lateral mass, and over-cephalad incline of C1 pedicle may be the risk anatomic factors of atlantooccipital joint injury.


Mamoru KawakamiWakayama Medical University, Kihoku Hospital Ito-gun, Japan

abstract

ComPariSon of SurgiCal outComeS for lumBar Degenerative SPonDYloliStHeSiS WitH neurogeniC ClauDiCation –

a ProSPeCtive, ComParative, multiCenter trialMamoru Kawakami, yoshiharu Kawaguchi, Seiji Ohtori,

Shigenobu Sato, Nobuo Kawaharaand members of the AOSpine Japan research Collaboration Consortium

Study design: a prospective observational cohort study was performed in 17 institutes of the aospine Japan Research Collaboration Consortium. This is now in progress.

Objective: There was no high evidence if spine fusion is effective in clinical outcomes for degenerative lumbar spondylolisthesis (Dls). In addition, it is still unknown which is the superior procedure in the outcomes among various spinal fusion techniques. The purpose of this study was to compare clinical and radiological outcomes in patients with Dls among surgical procedures.

Material and methods: surgical indication and methods were decided based on each institute’s standard practice. Inclusion criteria were diagnosis of a single level Dls with neurogenic claudication, slippage (>3mm) and failure of conservative treatments. Previous lumbar surgery, multi-level lss, other spinal disorders, oa of the lower extremity, osteoporosis, PaD and concomitant conditions that could compromise outcome assessment were excluded. Preoperative demographic data, operative time, ebl and complications were recorded. Vas for low back pain, leg pain and numbness and satisfaction, zCQ, JoabPeQ, eQ-5D and sRQ-D were used for patients’ self assessments. Radiological evaluation including X-rays and MRI were completed pre- and postoperatively (Po). Data were compared with surgical methods (Decompression only (D) vs. fusion and Posterolateral fusion (Plf) vs. lumbar Interbody fusion (lIf)). statistical analysis was used by sPss statistics. P<0.05 was considered as statistical significance.

results: Under present conditions, 120 cases were recruited. 88 patients were followed at 6 months Po. 10, 33 and 44 patients were divided into the D, Plf and lIf groups, respectively. There were no differences in preoperative demographic data, patient’s self assessment outcomes among the D and fusion (Plf and lIf) groups. However, slippage in the fusion group was greater than that in the D group (8.2 vs. 5.4mm, P=0.01). operative time and ebl in the D group were less than those in the fusion groups (113 vs. 171min, P<0.001, 58 vs. 290ml. P=0.001). The patients’ self assessments in each group were significantly improved after surgery. at 3 months Po, eQ-5D and acquired points of gait disturbance and psychological disorders in JoabPeQ were higher in the fusion group than those in the D group (0.81 vs. 0.66, 39 vs. 26, 19 vs. 9, P<0.05). at 6 months Po, there were no significant differences in outcome measures except RoM of l2-3 segment (D: 7.1, fusion: 4.4°, P<0.05). fusion rate was 73%. There were no significant differences in outcomes between the Plf and lIf except leg numbness at 3 months oP (Plf:25, lIf:16mm, P<0.05).

Conclusion: It is difficult to obtain precise conclusions in the present study because of small number of patients and short term follow-up. In some items, of which we used several patient’s self assessment tools, patients in the fusion group showed better outcomes at 3 months Po, compared with the D group. since anterior slippage in the D group was less than that in the fusion group, it is still unknown if decompression only can stand for all patients with Dls. further study is needed to evaluate the significance of fusion surgery.


seok-woo KimHallym University Sacred Heart HospitalAnyang, South Korea

abstract

tHe riSK of a fall in PatientS WitH CerviCal mYeloPatHY anDitS CliniCal SignifiCanCe

Seok-woo Kim, M.D.1, Joo-Sung Kim, M.D.1, Kwang-Jin lee, M.D.1,Keon-young Park, M.D.2, Keun-Ho Park, M.D.2

1 Spine Center, Department of Orthopaedic Surgery, Hallym University Sacred Heart Hospital,Hallym University College of Medicine, Anyang, South Korea

2 Department of Orthopaedic Surgery, Jeonju Korea Hospital, South Korea

Purpose: To analyze the risk of a fall in patients with cervical spondylotic myelopathy(CsM) and its clinical significance.

Material and methods: 40 patients with CsM who visited to our hospital from May 2014 to april 2015 were enrolled in this study. after confirmation of CsM based on MRI and Physical examination, patients were divided into three groups according to m-Joa score (Group a; severe; score <8, Group b; moderate; score 8-12, Group C; mild score >13). all patients enrolled in this study performed 4 functional assessment test including alternative-step Test (asT), six-Meter-Walk Test (sMT), sit-to-stand Test (sTsT), and Timed Up and Go Test (TUGT) to assess the risk of falls (Rof).

results: There were statistical significance between m-Joa score and Rof except for sMT. average time (seconds) for sTsT was 26.12±5.60, 20.99±5.92 and 15.37±3.41 in group a, b, C, respectively (p=0.001). although average time(s) for asT was 16.81±3.83, 14.39±4.05 and 12.37±3.95 in group a, b, C with no statistical significance (p=0.106), there was a significance between the value of Group a and C (p=0.047). average time(s) for TUGT was 31.86±17.05, 15.09±4.59, 18.04±9.32 in group a, b, C, respectively, showed statistical significance (p=0.000).

Conclusion: according to its severity of myelopathy, it took more time to carry out each Rof assessment tests. among 4 functional assessment tests of Rof, sTsT showed the most highest correlation with mJoa score. Careful attention of Rof will be needed in patients with myelopathy.

Key words: Cervical spine, Cervical spondylotic myelopathy, Gait disturbance, mJoa score, Risk of a fall


wei-shi liPeking University Third HospitalBeijing, China

abstract

analYSiS of SPino-PelviC Sagittal alignment in CHineSe Young PatientS WitH lumBar DiSC Herniation

wei-Shi li, Han Fei, Zhuo-ran Sun, Qing-wei MaPeking University Third Hospital

Purpose: Previous studies have reported the sagittal alignment in normal adults and several degenerative spinal diseases, but they seldom focused on young lDH patients, and there was a controversy about the impact of pelvic morphology on the pathogenesis of lDH. our research was to study the characteristics of the sagittal alignment in Chinese young lDH patients and explore the impact of pelvic morphology on the pathogenesis of lDH.

Material and methods: Retrospective analysis was applied to 100 young patients with lDH (age 18-35 years). The control group included 100 asymptomatic volunteers with matching age and gender. Coronal and sagittal parameters were measured on the anteroposterior and lateral radiograph of the whole spine, including lumbar lordosis (ll), pelvic incidence (PI), sacral slope (ss), pelvic tilt (PT), thoracic kyphosis (TK), sagittal balance (sVa). The cases were classified into 4 types according to position of apex of lumbar lordosis, and 3 PI groups including low PI group(PI<40°), medium PI group (40°≤PI<50°), and high PI group(PI≥50°).

results: In lDH group, the PI value had no difference with the control group. Compared with the control group, the average ll, ss, and TK were lower, the PT and sVa were higher, and the lordosis apex tended to be higher. The distribution of PI groups between the lDH group and the control group had no difference. Pairwise correlations were found among ll, PI, ss, and PT. TK and sVa were correlated with ll, ss, and PT.

Conclusion: PI doesn't show difference between Chinese young patients with lumbar disc herniation and normal population. Young lDH patients may have flat lumbar and thoracic curves, and lower sacral slope. The prorsal sagittal imbalance is regulated by both the spine and the pelvis.


guo-yan liangGuangdong General HospitalGuangzhou, China

abstract

reSearCH on aBnormal lePtin Signaling inaDoleSCent iDioPatHiC SColioSiS

leptin has been suggested to play a role in the etiology of adolescent Idiopathic scoliosis (aIs), however, the leptin levels in aIs girls are still a discrepancy, and no in vitro study of leptin in aIs is reported. We took a series of case-control studies, trying to understand whether leptin gene polymorphisms are involved in the etiology of the aIs or the change in leptin level is a secondary event, to assess the level of leptin receptor, and to evaluate the differences of response to leptin between aIs cases and controls. We screened all exons of leptin gene in 45 cases and 45 controls and selected six tag snPs to cover all the observed variations. association analysis in 446 aIs patients and 550 healthy controls showed no association between the polymorphisms of leptin gene and susceptibility/severity to aIs. Moreover, adipogenesis assay of bone mesenchymal stem cells (MsCs) suggested that the adipogenic ability of MsCs from aIs girls was lower than controls. after adjusting the differentiation rate, expressions of leptin and leptin receptor were similar between two groups. Meanwhile, osteogenesis assay of MsC showed the leptin level was similar after adjusting the differentiation rate, but the leptin receptor level was decreased in induced aIs osteoblasts. Immunocytochemistry and western blot analysis showed less leptin receptors expressed in aIs group. furthermore, factorial designed studies with adipogenesis and osteogenesis revealed that the MsCs from patients have no response to leptin treatment. our results suggested that leptin gene variations are not associated with aIs and low serum leptin probably is a secondary outcome which may be related to the low capability of adipogenesis in aIs. The decreased leptin receptor levels may lead to the hyposensitivity to leptin. These findings implied that abnormal peripheral leptin signaling plays an important role in the pathological mechanism of aIs.


Masayuki MiyagiKitasato University, School of MedicineKanagawa, Japan

abstract

DiSK DYnamiC ComPreSSion in ratS ProDuCeS long-laSting inCreaSeS in inflammatorY meDiatorS in DiSKS anD

inDuCeS long-laSting nerve inJurY anD regeneration of tHe afferent fiBerS innervating DiSKS: a PatHomeCHaniSm

for CHroniC DiSKogeniC loW BaCK Pain

Introduction: We previously reported intervertebral disk (IVD) injury induced up-regulation of inflammatory mediators. However, the IVD injury in animals incompletely models degenerated human IVDs causing diskogenic low back pain because human IVDs are also subject to compression. The purpose of the current study is to examine production of inflammatory mediators in IVDs and neuropeptides in dorsal root ganglia (DRGs) in rat models of IVD compression or/and injury.

Methods: experimental groups (controls, IVD injury, IVD compression, and their combination) of sprague Dawley rats were prepared. fluoro-Gold (fG) was applied into coccygeal IVDs. Inflammatory mediators in IVDs, including nGf, Tnf-alpha, Il-1-beta, and Il-6, were quantified using elIsa. DRGs were immunostained for CGRP (neuropeptides), aTf-3 (marker of nerve injury), and GaP43 (marker of nerve regeneration).

results: The upregulation of inflammatory mediators was transient in the IVD injury group, but delayed and persistent in the IVD compression group. In the combination group, the upregulation of inflammatory mediators was persistent through 8 weeks. The proportion of CGRP-immunoreactive (IR) neurons among fG-labeled neurons, remained significantly higher in the IVD injury, compression, and combination groups, than in the controls. In contrast, increases in the proportions of aTf-3-IR or GaP43-IR neurons in the IVD injury group animals were transient, but persistent in the compression and combination groups compared with controls.

Conclusion: Disk injury in rats produces persistent increases in neuropeptides in DRGs, but only transient increases in inflammatory mediators in IVDs. on the other hand, disk compression in rats produces a persistent increase in inflammatory mediators in IVDs and neuropeptides in DRGs. Moreover, disk compression induces persistent nerve injury and regeneration of the afferent fibers innervating IVDs.


naresh KumarNational University HospitalSingapore

abstract

role of intraoPerative SalvageD BlooD inmetaStatiC SPine tumour SurgerY -

eviDenCe tHrougH floW CYtometrY analYSiSNaresh Kumar, raymond lam, Aye Sandar Zaw, Gamaliel Tan,

Tony Setiobudi, Hee-Kit wong National University Health System, Singapore

Purpose: Intra-operative cell salvage (IoCs) has not been widely adopted in oncological surgery due to hypothetical concern of reinfusion of malignant cells. We conducted the study to evaluate the role of IoCs in combination with leucocyte depletion filter (lDf) in metastatic spine tumour surgery (MsTs) using quantitative flow cytometry tumour detection technique.

Material and methods: Patients with known primary epithelial tumour, operated for metastatic spinal disease, were recruited. blood samples were collected at 5 different stages during surgery: 2 stages (stage a and b) from patient vein during induction and at the time of maximum tumour manipulation, 3 stages (stage C, D and e) from the operative blood prior to IoCs processing, after IoCs processing and after IoCs-lDf processing respectively. of the samples taken at each stage, 5mls were analyzed for tumour cells using flow cytometry.

results: of 12 patients recruited, only 11 were included in final analysis. flow cytometry analysis of their samples showed that 8/11 patients had tumour cells in the unfiltered salvaged blood. In filtered salvaged blood, the tumour cell count was zero in the majority of samples (8/11 patients) while 3 patients’ samples had a few tumour cells. The difference between the mean tumour cell quantity in the samples taken from stage a and e was significant (P=0.04). similarly, the difference between the mean quantities of tumour cells in the samples in stage b and e was significant (P=0.01). However, there were no significant differences between the mean quantities of tumour cells when comparing the samples from either stage a and b, stage D and e or stage C and e.

Conclusion: IoCs-lDf was shown to be effective in removing tumour cells from blood salvaged during MsTs. If there were any tumour cells found, the quantity was significantly less than that in patient’s circulation. The results of this study supported the fact that IoCs-lDf treated blood in MsTs is safe for transfusion.


Bang-ping QianNanjing Drum Tower Hospital, Nanjing University Medical SchoolNanjing, China

abstract

iDentifiCation of Serum mir-146a anDmir-155 aS novel noninvaSive ComPlementarY BiomarKerS

for anKYloSing SPonDYlitiSBang-Ping Qian, M.D.1, Ming-liang Ji, M.D.1, yong Qiu, M.D.1, Bin wang, M.D.1,

yang yu, M.D.1, wei Shi, M.D.2, and yong-Feng luo, M.D.21 The Department of Spine Surgery,

Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, China2 Developmental Biology and Regenerative Medicine Program, Department of Surgery,

Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, USA

Purpose: To investigate differentially expressed serum microRnas (miRnas) between ankylosing spondylitis (as) patients and controls, and to evaluate the potential of miRnas as biomarkers for as.

Material and methods: an initial screening of miRna expression by solexa sequencing was performed using serum samples pooled from 10 as patients and 10 controls, respectively. subsequently, differential expression was validated using hydrolysis probe-based stem-loop quantitative reverse transcription polymerase chain reaction (qRT-PCR). furthermore, as patients were divided into group a (kyphosis <70°) and group b (kyphosis ≥70°). Disease activity and functional status were evaluated by bath ankylosing spondylitis Disease activity Index (basDaI) and the bath ankylosing spondylitis functional Index (basfI), respectively. The areas under the receiver operating characteristic (RoC) curves of identified miRnas were analyzed.

results: nineteen serum miRnas were differentially expressed in as patients compared with controls. following qRT-PCR confirmation, miR-146a and miR-155 were significantly up-regulated in as patients. The areas under the RoC curves using miR-146a and miR-155 were 0.917 and 0.964, respectively. Importantly, the miR-155 expression level in group b was significantly higher than that in group a. additionally, significant correlation was observed between miR-155 expression level and basDaI (r=0.5, p<0.01).

Conclusion: Detection of serum miRnas (miR-146a and miR-155) may serve as novel complementary biomarkers for as. Moreover, the expression level of miR-155 is suggested to be associated with disease activity and the severity of thoracolumbar kyphosis secondary to as.


Dino samartzisDepartment of Orthopaedics & Traumatology, University of Hong KongHong Kong

abstract

aoSaP reSearCH CollaBoration ConSortium multiCenter ProJeCtS - Degenerative SPonDYloliStHeSiS anD

SPine tuBerCuloSiS uPDateSDino Samartzis and the AOSAP research Collaboration Consortium

Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, SAR, China

Purpose: asia has tremendous resources to address clinical spine research. Multi-center studies are needed to address challenging objectives concerning spinal disorders. as such, the following presentation will address the construction of a network of spine institutes in the asia Pacific Region to address multi-center collaborative spine research.

Material and methods: over 33 spine institutes in the asia Pacific Region have been recruited as part of the consortium. Targeted projects involving the role of facet joint orientation in degenerative spondylolisthesis and spinal tuberculosis have been established.

results: findings from this consortium have provided further insights into the development of degenerative spondylolisthesis as well as re-defined the phenotype of facet joint orientation and its impact upon spine degeneration. based on this framework, a large-scale prospective multi-center study addressing the management of spinal tuberculosis has been established and is being executed.

Conclusion: We have established one of the world’s largest multi-center collaborative spine initiatives by number of spine institutes involved. This network provides a framework for collaborative research and to establish future spine studies that can be addressed quickly, and yield substantial sample size and power. This consortium has positioned asia Pacific in the forefront as leaders in multi-center spine research. This model has potential to be applied to other regions globally.


Kanchan sardaIndian Spinal Injuries CentreNew Delhi, India

abstract

Pre-CliniCal StuDieS to StanDarDize anD valiDate Stem Cell tranSPlantation in CaSe of DiSC Degeneration

Current treatments for disc degeneration fall into two categories: 1) Conservative, nonsurgical management which entails analgesics, rehabilitation programs, and lifestyle adjustments such as weight loss and 2) surgical intervention which involves spinal fusion and disc arthroplasty. Conservative management is the preferred treatment method for most cases of IVD degeneration, and only when patients do not benefit from such management that surgical fusion is indicated. However, neither conservative nor surgical management addresses the underlying process of IVD degeneration, and for many patients neither is it effective at relieving low back pain. furthermore, fusion surgery has significant downsides. along with the loss of flexibility between fused vertebrae, it may also result in increased stress and strain on adjacent discs and thus accelerate their degeneration, necessitating further surgical intervention.

Recent advances have been directed towards the potential of biologic therapies for the treatment of disc degeneration. one of the major, well-recognized events in disc aging and degeneration is the marked reduction in cell number and the decreased production of disc eCM. Various studies involving in vitro cultures, animal models as well as a few pilot studies on human subjects have been published to delineate the role of mesenchymal stem cells (MsCs) for the regeneration of IVD. These studies establish that MsCs can influence IVD cells to regenerate. However, several factors still need to be worked out before the potential of these cells may be translated to a clinical setting, the most important being to establish the grade of degeneration for which the cell therapy should be indicated, the dose of cells as well as the route of transplantation and the number of times the intervention is required.

To this end we proposed to co-culture MsCs and cells from the intervertebral disc in an attempt to develop a standardized protocol for transplantation of these cells for regeneration of IVD. The first step for undertaking this project was to establish primary culture of IVD cells from degenerated disc tissue obtained from surgical disc procedures performed on individuals with herniated discs and degenerative disc disease.

34 samples were collected from individuals undergoing surgical disc procedures and were cultured under various conditions of time, temperature and enzyme concentrations. We were able to standardize and validate the culture conditions for the culture of primary IVD cells and establish a reproducible protocol for primary cell cultures from degenerated disc tissue. further studies would involve establishing culture of mesenchymal stem cells from bone marrow and adipose tissue followed by co-culture of these two cell populations for undertaking studies for establishing dose and number of interventions required to achieve disc regeneration through stem cell based approaches.


pei-Qiang suThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou, China

abstract

aBnormal meSenCHYmal Stem Cell oSteogenetiCDifferentiation meDiateD BY melatonin iS relateD to

tHe DeformitY of PeDiCle in aiS PatientChong Chen1, Cai-Xia Xu2, Tai-Feng Zhou1, Bo Gao3, Hang Zhou1,

Dong-Sheng Huang3, Pei-Qiang Su1

1 Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University2 Research Center of Translational Medicine, The First Affiliated Hospital of Sun Yat-sen University

3 Orthopaedic Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University

Purpose: Membranous ossification abnormalities in patients with adolescent idiopathic scoliosis (aIs) remain incompletely understood. To investigate abnormalities in the melatonin signaling pathway and cellular response to melatonin in membranous ossification and the deformity of pedicle in patients with aIs, we performed a case-control study of osteogenic differentiation of human mesenchymal stem cells (hMsCs) and prospective study on the morphometry of pedicles.

Material and methods: aIs was diagnosed by physical and radiographic examination. hMsCs were isolated from bone marrow of patients with aIs and control subjects (n=12 each), and purified by density gradient centrifugation. Melatonin receptors (MTnRs) 1 and 2 were detected by western blotting. osteogenic differentiation was induced by culturing cells in osteogenic media containing vehicle or 50 nM melatonin. alkaline phosphatase (alP) activity assays, and real-time reverse-transcription polymerase chain reaction (RT-PCR) analysis were performed. Meanwhile, the pedicles’ morphometry between T1 and l5 in 60 surgically treated patients with aIs and T1 and T12 in 60 control subjects (sex-age matched) was analyzed by computed tomographic scans.

results: Compared with controls, MTnR2 demonstrated low expression in aIs group. Melatonin elevated alP activity and up-regulated the expression of genes involved in osteogenic differentiation [i.e., alP, osteopontin, osteocalcin, runt-related transcription factor 2 (RUnX2)] in the control (P<0.05), but not the aIs groups. Compared with non-apical vertebrae in non-structural curve (naV-nsC), difference between convex and concave side of pedicle width in apical vertebrae in structural curve (aV-sC) was most obvious (P<0.05), non-apical vertebrae in structural curve (naV-sC) and apical vertebrae in non-structural curve (aV-nsC) were secondary (P<0.05) in aIs. Difference between aIs and controls of pedicle width was significantly in T3 and T4, which were the narrowest pedicle in thoracic vertebrae (P<0.05).

Conclusion: hMsCs in aIs exhibit abnormal cellular responses to melatonin during osteogenic differentiation, which may be linked to abnormal membranous ossification of pedicle deformity. Pedicles in aV-sC might be the origin region of abnormal membranous ossification in aIs.


Kentaro yamaneNational Hospital Organization Fukuyama Medical CenterHiroshima, Japan

abstract

neural regeneration in mouSe SPinal CorD inJurY moDeluSing PHotoreaCtive gelatin anD groWtH faCtorS WitH

Collagen BinDing Domain

Brief description of project: The administration of growth factors and cells for treatment of spinal cord injury has shown limited benefits. In the present study, we investigate the effect of new drug delivery system (DDs) using photoreactive gelatin(PG) and growth factors with collagen binding domein (CbD).

Objectives / Milestones: We examined whether the combinational methods of PG and CbD-HGf can be effective for the spinal transected mouse model. spinal function was evaluated by the recovery of hindlimb motor function using bMs, the recovery of signal conduction in motor pathway by measuring MePs. Immunochistochemistry was performed on the following primary antibodies: anti-GaP43, anti-GfaP, and anti-MbP. We examined whether the combinational methods of PG and CbD-HGf can be effective for the spinal transected mouse model.


guo-yong yinThe First Affiliated Hospital of Nanjing Medical University, JiangsuNanjing, China

abstract

CoX-2 DefiCienCY CauSeS Degenerative CHangeS in lumBar SPine

Objective: based on previous findings that cyclooxygenase-2 (CoX-2) is a critical molecule in chondrocyte differentiation and skeletal repair, we hypothesized that CoX-2 deficiency or inhibition affects the ossification of vertebral endplates (VeP) and degeneration of intervertebral discs (IVD) in the pathogenesis of low back pain (lbP). We tried to dissect the CoX-2 working mechanism and its interacting molecules such as bone morphogenetic proteins (bMPs) and Hedgehog (Hh). finally, we discussed the effect of nsaIDs and selective CoX-2 inhibitor on degenerative spinal diseases.

Methods: lumbar spinal samples were collected from both 5-month-old Cox-2 mutant (Cox2-/-) mice and their wild type (WT) littermates for radiographic, histological, and immunohistochemical (IHC) studies. Rat nucleus pulposus (nP) cells isolated under microscopy were cultured and treated with prostaglandin e2 (PGe-2). Real-time PCR (RT-PCR) analysis showed that PGe-2 treatment did not cause evident changes in mRna expression of TGf-β superfamily members, VeGfs, proinflammatory cytokines, major cartilage matrix proteins and matrix degrading enzymes. as the most significant change was downregulation of sonic Hh (shh) in rat nP cells, we hypothesized that shh may affect adjacent VeP cells through an autocrine or paracrine mechanism. because of technical difficulties, we used mouse articular chondrocytes (maC), instead of VeP chondrocytes, for subsequent experiments. maC were treated with a mouse recombinant shh protein and RT-PCR was performed to assess the changes in the expression of bMPs and VeGfs. While shh did not significantly change the expression of bMP-2, alK3, 6, smad1, 5 and 8, it upregulated noggin expression. IHC studies were done with the antibodies for CoX-2, shh, noggin, phosphorylated smad1 (psmad1) and VeGfR2 (pVeGfR2) in the following samples: in vitro cultured mouse IVD samples treated with either CoX-2 inhibitor Cerebrex or vehicle, the IVD samples from both WT and Cox2-/- mice, and the VeP samples from patients undergoing surgery due to IVD degeneration.

results: Radiographic and histological examinations showed that the VeP ossification in Cox2-/- mice was delayed compared to WT ones. To determine if these changes were resulted from the activity of PGe-2 in IVD cells, we treated rat nP cells with PGe-2 and RT-PCR analysis of the relevant genes demonstrated that PGe-2 upregulated expression of shh in these cells. To confirm a possible paracrine mechanism through which shh interacts with bMP signaling in the VeP cells, we treated maC with a shh protein. The results showed that shh upregulated noggin expression. Consistent with these in vitro findings, IHC studies showed that noggin expression was increased while psmad1 expression decreased in the VeP of Cox2-/- mice compared to their WT littermates. IHC studies revealed the decreased expression of shh and noggin and increased expression of CoX-2 and psmad1 in the human VeP samples from patients with Modic changes and severe IVD degeneration (Group 1) compared the VeP samples with milder degeneration and without Modic changes (Group 2). In an organ culture system, treatment with Celebrex decreased CoX-2 activity in cultured mouse IVD samples. subsequently, Celebrex enhanced shh and noggin expression in these samples, thus inhibiting activation of bMP-smad1 pathway as shown by weak psmad1 immunostaining.

Conclusion: CoX-2 deficiency or inhibition results in decreased production of PGe-2 and upregulation of shh and noggin, which inhibits the activation of bMP-smad1 pathway and delayed ossification of VeP and less severe IVD degeneration. The novel findings may pave a way to the clinical use of the CoX-2 inhibitor to prevent the progression of degenerative spinal changes in lbP patients, especially in early stage.

Key words: Intervertebral disc, endplate, degeneration, ossification Cyclooxygenase; bone morphogenetic protein; sonic Hedgehog


guo-yong yinThe First Affiliated Hospital of Nanjing Medical University, JiangsuNanjing, China

abstract

iSCHemiC PreConDitioning enHanCeS autoPHagY But SuPPreSSeS autoPHagiC Cell DeatH in rat SPinal neuronS

folloWing iSCHemia-rePerfuSion

autophagy serves to eliminate damaged proteins and organelles under normal physiological conditions and can be accelerated by pathological stress, possibly as a cytoprotective mechanism. brief periods of ischemia (ischemic preconditioning or IPC) can reduce neuronal death in response to subsequent severe ischemic insults. Ischemic preconditioning also induces autophagy, but the contribution of autophagy to IPC-associated neuroprotection remains unclear. We investigated the contribution of autophagy to IPC-mediated neuroprotection in rats subjected to ischemic spinal cord injury. fifty adult rats were randomly assigned to either (1) a sham group receiving anesthesia and surgical preparation (n=5), (2) an ischemia/reperfusion (I/R) group (n=20) subjected to 0.5h ischemia followed by 3, 6, 12, or 24h reperfusion, (3) an IPC group receiving three cycles of 5 min ischemia followed by 5 min of reperfusion (n=5), or (4) an IPC+I/R group (n=20). Hematoxylin–eosin (He) and immunohistochemical staining were performed to evaluate spinal neuron survival in the four treatment groups. autophagic activity was investigated by electron microscopy and by immunohistochemical and Western blot analyses of the autophagosome marker lC3-II and the autophagy-associated bH3 protein beclin-1. Changes in bcl-2/beclin-1 complex association and bcl-2 phosphorylation (p-bcl-2) were examined by co-immunoprecipitation and Western blot analyses. In the I/R group, lC3-II was significantly elevated after 3 hours of reperfusion, but declined significantly by 24h. at 24h, I/R rats exhibited extensive spinal damage and decreased neuronal survival. In the IPC+IR group, neuronal death was reduced and expression of lC3-II sustained throughout the 24h reperfusion period. In I/R group, expression of (inactive) P-bcl-2(ser70) was increased significantly during reperfusion and was accompanied by dissociation of the bcl-2/beclin-1 complex and increased beclin-1 expression. Preconditioning inhibited these changes in p-bcl-2, beclin-1, and bcl-2/beclin-1 complex expression. Ischemic preconditioning appears to sustain the beneficial effects of autophagic lysosomal degradation during I/R while inhibiting autophagic cell death.

Key words: autophagy; spinal cord; ischemic preconditioning (IPC); ischemia/reperfusion; autophagic cell death


P RoGR aM aT a Gl anC e

September 25, 2015 friday (Day 1) 08:20 - 17:15

asia Pacific research Colloquium

(Venue: Plenary Hall)

associationColloquium i

(Venue: Conference Hall 1)

associationColloquium ii

(Venue: Conference Hall 2)

innovativenon-Clinical Colloquium(Venue: Conference Hall 3)

reSearCH PaPer PreSentation

aSia PaCifiCSPine eXPert forum

CroSS-StraitortHoPaeDiC DaY(Language: Mandarin)

gloBal innovative anD ControverSial

SPine SurgerY Summit

08:20 - 09:00Plenary session - spine concepts


09:00 - 09:30

oPening CeremonY(Venue: Plenary Hall)09:30 - 10:00

Coffee break10:00 - 10:30

session I: aIs and Ds

session I: Degenerative scoliosis session I:

Complicated adult spinal problem management

session I: Practice management

10:30 - 11:00

11:00 - 11:30

11:30 - 12:00 session II: osteoporotic vertebral collapse

and kyphotic deformityCoffee breaksession II:

Pediatric spinal deformity management

12:00 - 12:30Coffee break

session II: Kyphosis

session II: Complex spine problem12:30 - 13:00

lunch(Venue: Hall 2, G/F)

13:00 - 13:30lunch

(Venue: Hall 2, G/F)lunch

(Venue: Hall 2, G/F) 13:30 - 14:00

14:00 - 14:30

Plenary session - spine updates


Plenary session - spine updates


session III: spinal infection management Plenary session -

spine updates(Venue: Plenary Hall)

14:30 - 15:00

session III: spinal deformity15:00 - 15:30

session IV: Minimal invasive spinal surgerysession IV:

Cervical spinal deformitysession III: spinal disease

Coffee break15:30 - 16:00

Coffee breaksession III:

Private practice, stand & deliver: your money or your life

16:00 - 16:30 Coffee break

Coffee break session V: Cervical spinal surgerysession V:

Cervical disc fusion anddisc replacement

16:30 - 17:00session IV:

emerging technologies & best Presentation award17:00 - 17:15

19:00 - 21:30gala Dinner(Venue: sky100)

*Admission by ticket

Program

Time

Program

Time


P RoGR aM aT a Gl anC e

September 26, 2015 Saturday (Day 2) 08:20 - 17:15

September 27, 2015 Sunday (Day 3) 08:20 - 12:00

association Colloquium i(Venue: Conference Hall 1)

association Colloquium ii(Venue: Conference Hall 2)

innovative non-Clinical Colloquium(Venue: Conference Hall 3)

aSia PaCifiC miSS DaY aSia PaCifiCneuroSurgerY aPeX

inStrumentS anD imPlant DeSigning

DeveloPment WorKSHoP

08:20 - 09:00Plenary session - How to get involved in implant / instrument development

(Venue: Plenary Hall) session I: Korean spinal neurosurgery society

Plenary session - How to get involved in implant / instrument development

(Venue: Plenary Hall)09:00 - 09:30Coffee break Coffee break

09:30 - 10:00session I:

MIs lumbar spinaldecompressions session I:

experience sharing in surgeon andindustrial partners perspectives

Coffee break

10:00 - 10:30session II:

Japanese society ofspinal surgery


11:00 - 11:30

session II: MIs lumbar spinal fusion

session III: Chinese Congress of

neurological surgeons


12:00 - 12:30 session II: Debate on intra-operative

neuromonitoring12:30 - 13:00

lunch(Venue: Hall 2, G/F)

13:00 - 13:30 lunch(Venue: Hall 2, G/F)13:30 - 14:00

14:00 - 14:30Plenary session -

Deformity surgery - anterior or not?(Venue: Plenary Hall)

session IV: Taiwan neurosurgical

spine society

Plenary session - Deformity surgery - anterior or not?

(Venue: Plenary Hall)14:30 - 15:00 session III: occipital cervical and

upper cervical spinal problem Coffee break15:00 - 15:30

session IV:Cervical spine instrumentation

Coffee break

session III: Pushing the frontier of surgical education

15:30 - 16:00session V:

Hong Kong neurosurgery spine Interest Group, Hong Kong neurosurgical society


session V: biologics and new innovation in MIs

surgery

16:30 - 17:00

17:00 - 17:15

association Colloquium i(Venue: Conference Hall 1)

association Colloquium ii(Venue: Conference Hall 2)

innovative non-Clinical Colloquium(Venue: Conference Hall 3)

ControverSial & ComPliCateD CaSeS DaY

aSia PaCifiC Painmanagement DaY

HoW to SuCCeSSfullY Craft anD CommuniCate Your

BranDS aS a Surgeon

08:20 - 09:00

session I: Difficult case / spinal infection

session I: neuropathic pain Master the brand called YoU™ - how to

successfully craft and communicate your brand as a surgeon

09:00 - 09:30

09:30 - 10:00


session II: Difficult case / spinal trauma

session II: neuropathic pain


11:00 - 11:30Master the brand called YoU™ - how to successfully craft and communicate your

brand as a surgeon (con't)11:30 - 12:00

Program

Time

Program

Time


sC I e nT I f IC P RoGR aM

time agenDa SPeaKer

08:20 - 08:30 Welcome Introduction Chung-Chek Wong (Malaysia)

08:30 - 09:25 Plenary Session - Spine concepts (Venue: Plenary Hall)

moderators:Ying-Kei Chan (Hong Kong),Yong Qiu (China),Chung-Chek Wong (malaysia)

08:30 - 08:45 The transition from degenerative disorders to spinal deformity sigurd berven (United states)

08:45 - 09:00 General overview of the etiology of aIs in China Yong Qiu (China)

09:00 - 09:15 anterior spinal surgery - the ups and downs Keith luk (Hong Kong)

09:15 - 09:25 Panel discussion & Q&a

09:25 - 09:55 oPening CeremonY (Venue: Plenary Hall)

09:55 - 10:15 Coffee Break

10:15 - 12:03 Session i: aiS and DS moderators: Sigurd Berven (united States), Bang-Ping Qian (China)

10:15 - 10:23 Distal veterbra selection in aIs Jian-Xiong shen (China)

10:23 - 10:31 abnormal mesenchymal stem cell osteogenetic diffenertiation mediated by melatonin is related to the deformity of pedicle in aIs patient

Pei-Qiang su (China)

10:31 - 10:39 Research on abnormal leptin signaling in adolescent idiopathic scoliosis Guo-Yan liang (China)

10:39 - 10:47 scoliosis model in an asymmetric force bipedal rat and bone micro-architecture adaptations of vertebrae

zhe-Hao Dai (China)

10:47 - 10:55 analysis of spino-pelvic sagittal alignment in Chinese young patients with lumbar disc herniation

Wei-shi li (China)

10:55 - 11:03 3-3D classification of adolescent idiopathic scoliosis Hubert labelle (Canada)


11:13 - 11:21 Disk dynamic compression in rats produces long-lasting increases in inflammatory mediators in disks and induces long-lasting nerve injury and regeneration of the afferent fibers innervating disks: a pathomechanism for chronic diskogenic low back pain

Masayuki Miyagi (Japan)

11:21 - 11:29 Pre-clinical studies to standardize and validate stem cell transplantation in case of disc degeneration

Kanchan sarda (India)

11:29 - 11:37 studies in regeneration of the intervertebral disc sigurd berven (United states)

11:37 - 11:45 Ischemic preconditioning enhances autophagy but suppresses autophagic cell death in rat spinal neurons following ischemia-reperfusion

Guo-Yong Yin (China)

11:45 - 11:53 neural regeneration in mouse spinal cord injury model using photoreactivegelatin and growth factors with collagen binding domain

Kentaro Yamane (Japan)



12:10 - 13:00 Session ii: Kyphosis moderators: Hubert labelle (Canada),Yong Qiu (China)

12:10 - 12:18 Chronic paraspinal muscle injury model in rat Tack-Geun Cho (south Korea)

12:18 - 12:26 Identification of serum miR-146a and miR-155 as novel noninvasive complementary biomarkers for ankylosing spondylitis

bang-Ping Qian (China)

12:26 - 12:34 loss of shox2 in nucleus pulposus cell promote intervertebral disc degeneration zhao-Min zheng (China)

12:34 - 12:42 etiolgy study on congenital scoliosis Jian-Xiong shen (China)


13:00 - 14:00 Lunch (Venue: Hall 2, G/F)

aSia PaCifiC reSearCH ColloQuium

DaY 1 friday, September 25, 2015Plenary HallProgram Chairman: Yong Qiu (China) A

M

english Session


time agenDa SPeaKer

14:00 - 15:20 Plenary Session - Spine updates(Venue: Plenary Hall)

moderators: lawrence Haber (united States),Yong Qiu (China),Chung-Chek Wong (malaysia)

14:00 - 14:15 Growth modulation of the spine lawrence Haber (United states)

14:15 - 14:30 etiology and classification of l5-s1 spondylolisthesis Hubert labelle (Canada)


14:40 - 14:55 overseas Telecast should we believe everything we read in journals?

bart Koes (netherlands)

14:55 - 15:10 overseas Telecast Knowledge forum on spinal trauma

alexander Vaccaro (United states)


15:20 - 16:13 Session iii: Spinal disease moderators: Sigurd Berven (united States),Yong Qiu (China)

15:20 - 15:28 Comparison of surgical outcomes for lumbar degenerative spondylolisthesis with neurogenic claudication - a prospective, comparative, multicenter trial

Mamoru Kawakami (Japan)

15:28 - 15:36 The risk of a fall in patients with cervical myelopathy and its clinical significance

seok-Woo Kim (south Korea)

15:36 - 15:44 Risk of atlantooccipital joint injury during C1 pedicle screw insertion:a CT-based morphology study of atlas

Da-Geng Huang (China)

15:44 - 15:52 aosaP research collaboration consortium multicenter projects - degenerative spondylolisthesis and spine tuberculosis updates

Dino samartzis (Hong Kong)

15:52 - 16:00 Role of intraoperative salvaged blood in metastatic spine tumour surgery - evidence through flow cytometry analysis

naresh Kumar (singapore)

16:00 - 16:08 Impact of tranexamic acid on red blood cell transfusion in spinal surgery

Rupinder Chahal (India)



16:35 - 17:15 Session iv: emerging technologies & Best Paper Presentation award

moderator:Bang-Ping Qian (China)

16:35 - 16:43 CoX-2 deficiency causes degenerative changes in lumbar spine Guo-Yong Yin (China)

16:43 - 16:51 Comparison between balloon kyphoplasty alone and short segmental fixation

liang Chen (China)

16:51 - 16:59 Minimally invasive approaches to the spine for scoliosis lawrence Haber (United states)


17:05 - 17:10 best Paper Presentation award Yong Qiu (China)

17:10 - 17:15 Closing Remarks

aSia PaCifiC reSearCH ColloQuium

DaY 1 friday, September 25, 2015Plenary HallProgram Chairman: Yong Qiu (China) english SessionP

M


time agenDa SPeaKer

08:20 - 09:25 Plenary Session - Spine concepts(This session is held in Plenary Hall. Please refer to Page 50 for detail program.)



aSia PaCifiC SPine eXPert forum

10:15 - 11:30 Session i: Degenerative scoliosis moderators:ajoy Shetty (india),Koon-man Sieh (Hong Kong)

10:15 - 10:25 Chinese association of spine and spinal Cord: Degenerative scoliosis

Yong Hai (China)

10:25 - 10:35 Philippine spine society: Decision making in degenerative scoliosis

Jose Manuel Ignacio (Philippines)

10:35 - 10:45 association of spine surgeons of India: surgery in degenerative lumbar spinal stenosis associated with scoliosis, role of instrumentation and level of fusion

Raghava Mulukutla (India)

10:45 - 10:55 Korean society of spine surgery: Proximal junctional failure after long instrumented spinal fusion for degenerative lumbar scoliosis with dynamic sagittal imbalance

Kee-Yong Ha (south Korea)

10:55 - 11:05 Taiwan spine society: Intraoperative CT with integrated navigation in posterior scoliosis surgery

Meng-Huang Wu (Taiwan)


11:30 - 12:30 Session ii: osteoporotic vertebral collapse and kyphotic deformity

moderators:Yen-Yao li (taiwan),raghava mulukutla (india)

11:30 - 11:40 association of spine surgeons of India: Planning instrumentation in osteoporotic spine techniques to avoid failure

ajoy shetty (India)

11:40 - 11:50 Hong Kong orthopaedic association, spine Chapter: Cement reinforcement techniques in osteoporotic spinal fractures

Raymond Wong (Hong Kong)

11:50 - 12:00 Hong Kong Minimal Invasive spinal surgery society: osteoporotic and kyphotic deformity: the basic science in sagittal balance

Koon-Man sieh (Hong Kong)

12:00 - 12:10 Korean society of spine surgery: Coronal imbalance after iliac screw fixation for degenerative lumbar scoliosis with dynamic sagittal imbalance

Kee-Yong Ha (south Korea)



aSSoCiation ColloQuium i

DaY 1 friday, September 25, 2015Conference Hall 1Program Chairman: Ying-Kei Chan (Hong Kong) A

M

english Session


time agenDa SPeaKer

14:00 - 14:40 Plenary Session - Spine updates (This session is held in Plenary Hall. Please refer to Page 51 for detail program.)

aSia PaCifiC SPine eXPert forum

14:40 - 15:10 Session iii: Spinal deformity moderators: ing-Ho Chen (taiwan),Shu-Hua Yang (taiwan)

14:40 - 14:50 Taiwan spine society: Correction of sagittal plane deformity - goals and techniques

Ing-Ho Chen (Taiwan)

14:50 - 15:00 Taiwan spine society: application of spinal osteotomies to adult spinal deformity

shu-Hua Yang (Taiwan)

15:00 - 15:10 Taiwan spine society: surgical treatment of idiopathic scoliosis

shih-Tien Wang (Taiwan)

15:10 - 16:00 Session iv: Cervical spinal deformity moderators: ram Chaddha (india),raymond Wong (Hong Kong)

15:10 - 15:20 Korean society of spine surgery: Distraction arthrodesis of the atlantoaxial facet joint for the treatment of occipital neuralgia caused by C2 nerve root compression

Jin s. Yeom (south Korea)

15:20 - 15:30 Korean society of spine surgery: Posterior column reconstruction for laminectomy defect

Jin s. Yeom (south Korea)

15:30 - 15:40 Chinese association of spine and spinal Cord: severe cervical spine kyphosis treated with anterior approach surgery

zhong-Jun liu (China)

15:40 - 15:50 association of spine surgeons of India: Kyphotic cervical spondylotic myelopathy - outcome of posterior only surgery using cervical pedicle screws

bidre Upendra (India)



16:15 - 17:15 Session v: Cervical disc fusion and disc replacement moderators: Kee-Yong Ha (South Korea),Bidre upendra (india)

16:15 - 16:25 Hong Kong Minimal Invasive spinal surgery society: Cervical disc hybrid surgery in 2 segments disc degeneration – clinical experience

Hung-Tsan Chow (Hong Kong)

16:25 - 16:35 Chinese association of spine and spinal Cord: Cervical fusion and disc replacement

Yong Hai (China)

16:35 - 16:45 association of spine surgeons of India: When not to do a cervical TDR?

Ram Chaddha (India)

16:45 - 16:55 Hong Kong orthopaedic association, spine Chapter: Critical review of multiple level cervical fusion, disc replacement and hybrid construct



17:05 - 17:15 summary & Closing Remarks Ying-Kei Chan (Hong Kong)


DaY 1 friday, September 25, 2015Conference Hall 1Program Chairman: Ying-Kei Chan (Hong Kong) P

M

english Session


time agenDa SPeaKer

08:20 - 09:10 Plenary Session - How to get involved in implant/instrument development (This session is held in Plenary Hall. Please refer to Page 66 for detail program.)


aSia PaCifiC miSS DaY

09:40 - 10:35 Session i: miS lumbar spinal decompressions moderators: luthfi gatam (indonesia),li-min rong (China)

09:40 - 09:50 Hong Kong orthopaedic association, spine Chapter: Review of lumbar stenosis

Chung-Ting Wong (Hong Kong)

09:50 - 10:00 Hong Kong Minimal Invasive spinal surgery society: Percutaneous endoscopic lumbar diskectomy:technical pearls to tackle different types of prolapse

Ying-Kei Chan (Hong Kong)

10:00 - 10:10 Philippine spine society: MIs lumbar spinal degeneration: transforaminal P.e.l.D. - a game-changer for extraforaminal disk herniations

Dave anthony Dizon (Philippines)

10:10 - 10:20 Hong Kong Minimal Invasive spinal surgery society: options of MIs decompression technique & MIs training

Ying-Kei Chan (Hong Kong)



11:05 - 12:30 Session ii: miS lumbar spinal fusion moderators: Dave anthony Dizon (Philippines), Dong-Sheng Huang (China)

11:05 - 11:15 Hong Kong orthopaedic association, spine Chapter: Minimal invasive posterior lumbar interbody fusion (MasT-PlIf)

lun-Kit sun (Hong Kong)

11:15 - 11:25 Hong Kong Minimal Invasive spinal surgery society: MIs anterior lumbar spinal fusion - the choice between Mini-alIf and olIf

Hung-Tsan Chow (Hong Kong)

11:25 - 11:35 Guangdong spinal surgery association: evaluation of safety related to XlIf

li-Min Rong (China)

11:35 - 11:45 Guangdong spinal surgery association: a clinical research: Multifidi lateral approach for TlIf withnf-CJT zygopophysis retractor

Jian-Ting Chen (China)

11:45 - 11:55 Indonesian orthopaedic association: MIs TlIf vs open procedure, which one is better?

luthfi Gatam (Indonesia)

11:55 - 12:05 Guangdong spinal surgery association: Post-operative intervertebral disc height after posterior lumbar interbody fusion at long-term follow-up: a retrospective study

Jian-Ting Chen (China)

12:05 - 12:15 Guangdong spinal surgery association: MIs-TlIf for spondylolisthesis, two years follow-up

li-Min Rong (China)




DaY 2 Saturday, September 26, 2015Conference Hall 1Program Chairman: Ying-Kei Chan (Hong Kong) A

M

english Session


time agenDa SPeaKer

14:00 - 14:40 Plenary Session - Deformity surgery - anterior or not? (This session is held in Plenary Hall. Please refer to Page 67 for detail program.)

aSia PaCifiC miSS DaY

14:40 - 15:10 Session iii: occipital cervical and upper cervical spinal problem moderators: Seok-Woo Kim (South Korea),Haw-Chou lee (Singapore)

14:40 - 14:50 Korean society of spine surgery: Irreducible atlanto-axial dislocation


14:50 - 15:00 Philippine spine society: Management of occipito-cervical and upper cervical spine pathology

Ronald Tangente (Philippines)

15:00 - 15:10 Hong Kong orthopaedic association, spine Chapter: atlantoaxial instability

Kam-Kwong Wong (Hong Kong)

15:10 - 16:00 Session iv: Cervical spine instrumentation moderators:Koon-man Sieh (Hong Kong), Chung-ting Wong (Hong Kong)

15:10 - 15:20 association of spine surgeons of India: Can we decrease the lateral perforations during pedicle screw insertion in the lower cervical spine

bidre Upendra (India)

15:20 - 15:30 Korean society of spine surgery: Multilevel CsM: how to choose between laminoplasty and instrumented cervical laminectomy


15:30 - 15:40 Guangdong spinal surgery association: The Magerl technique combined with single laminar clamp for management of atlantoaxial dislocation

shao-Yu liu (China)

15:40 - 15:50 Hong Kong Minimal Invasive spinal surgery society: a good method to prevent fall back in cervical laminoplasty




16:15 - 17:15 Session v: Biologics and new innovation in miS surgery moderators: Jose manuel ignacio (Philippines),lun-Kit Sun (Hong Kong)

16:15 - 16:25 Chinese association of spine and spinal Cord: artificial vertebral body fabricated by 3D printing - the result of clinical trial and related research

zhong-Jun liu (China)

16:25 - 16:35 Guangdong spinal surgery association: The clinical results of posterior unilateral pedicle screw fixation plus lumbar interbody fusion

shao-Yu liu (China)

16:35 - 16:45 Philippine spine society: MIs image guided TlIf with unilateral pedicle screw fixation versus bilateral screw fixation

Jose Joefrey arbatin (Philippines)

16:45 - 16:55 Guangdong spinal surgery association: Use of 3D CT reconstruction to establish the ideal entry point for pedicle screws in idiopathic scoliosis

Dong-sheng Huang (China)


17:05 - 17:15 summary & Closing Remarks Ying-Kei Chan (Hong Kong)


DaY 2 Saturday, September 26, 2015Conference Hall 1Program Chairman: Ying-Kei Chan (Hong Kong) P

M

english Session


ControverSial & ComPliCateD CaSeS DaY

time agenDa SPeaKer

08:20 - 08:30 Welcome Introduction Ying-Kei Chan (Hong Kong)

08:30 - 10:00 Session i: Difficult case / Spinal infection moderators: Kyu-Yeol lee (South Korea),Kam-Kwong Wong (Hong Kong)

08:30 - 08:40 Guangdong spinal surgery association: Hemivertebrae excision for the treatment of congenital scoliosis -clinical results and complications

Dong-sheng Huang (China)

08:40 - 08:50 Hong Kong Minimal Invasive spinal surgery society: Retrospective review of thoracic myelopathy

Joshua Ko (Hong Kong)

08:50 - 09:00 Indonesian orthopaedic association: Prediction model in determining the success of managing Tb-spine by surgery

Charles simanjuntak (Indonesia)

09:00 - 09:10 Philippine spine society: Restoring sagittal profile in patients with tuberculous spondylitis with image guided posterior stabilization

Jose Joefrey arbatin (Philippines)

09:10 - 09:20 Philippine spine society: a typical case presentation: spinal tuberculosis presenting as diskitis

Dave anthony Dizon (Philippines)

09:20 - 09:30 Indonesian orthopaedic association: The experience of management of tuberculosis spine in Indonesia

luthfi Gatam (Indonesia)

09:30 - 09:40 association of spine surgeons of India: Recalcitrant post-operative lumbar diskitis

Ram Chaddha (India)

09:40 - 09:50 Hong Kong Minimal Invasive spinal surgery society: My worst case with a revision case of flatback with poor sagittal balance

Koon-Man sieh (Hong Kong)



10:20 - 12:00 Session ii: Difficult case / Spinal trauma moderators:Jose Joefrey arbatin (Philippines), Charles Simanjuntak (indonesia)

10:20 - 10:30 Hong Kong orthopaedic association, spine Chapter: TlIf revision

Kam-Kwong Wong (Hong Kong)

10:30 - 10:40 Korean society of spine surgery: The prognostic factors of neurologic recovery in spinal cord injury

Kyu-Yeol lee (south Korea)

10:40 - 10:50 Malaysia spine society: endoscopic surgery in cervical spine

abdul Halim Yusof (Malaysia)

10:50 - 11:00 Korean society of spine surgery: The analysis of the outcome of short and long segment posterior instrumentation for thoracolumbar bursting fractures

Kyu-Yeol lee (south Korea)

11:00 - 11:10 Hong Kong Minimal Invasive spinal surgery society: from vertebroplasty to lordoplasty-osteoporotic collapse


11:10 - 11:20 Philippine spine society: Kyphoplasty for steroid induced osteoporosis

Ronald Tangente (Philippines)

11:20 - 11:30 Malaysia spine society: low lumbar fracture in ankylosing spondylitis

lim-beng saw (Malaysia)

11:30 - 11:40 association of spine surgeons of India: blindness following uncomplicated cervical disc surgery, surgeon's nightmare

Raghava Mulukutla (India)


11:50 - 12:00 Grand summary & Closing Remarks Ying-Kei Chan (Hong Kong)


DaY 3 Sunday, September 27, 2015Conference Hall 1Program Chairman: Ying-Kei Chan (Hong Kong) english Session


time agenDa SPeaKer08:20 - 09:25 Plenary Session - Spine concepts

(This session is held in Plenary Hall. Please refer to Page 50 for detail program.)



CroSS-Strait ortHoPaeDiC DaY海峽兩岸脊柱日

10:15 - 11:40 Session i: Complicated adult spinal problem management 第一節：複雜成人脊椎問題的治療

moderators:Joshua Ko (Hong Kong), zhong-Jun liu (China)高天佑 (香港 )，劉忠軍 (中國大陸 )

10:15 - 10:25 Guangdong association of spine and spinal Cord廣東省康復醫學會脊柱脊髓專業委員會 :application of traction in complex spinal deformity牽引在複雜脊柱畸形中的應用

Hui liu (China) 劉輝 (中國大陸 )

10:25 - 10:35 Guangdong spinal surgery association 廣東省醫學會脊柱外科學分會 : auto bone cage for the treatment of lumbar spine instability 自體骨 Cage成形治療腰椎不穩症

Jian li (China) 李健 (中國大陸 )

10:35 - 10:45 Guangdong spinal surgery association 廣東省醫學會脊柱外科學分會 : Mid-long term results of lumbar artificial disc replacement 人工腰椎間盤置換術的中長期療效分析

an-Jing liang (China) 梁安靖 (中國大陸 )

10:45 - 10:55 Hong Kong orthopaedic association, spine Chapter 香港骨科醫學會脊柱分會 : surgical management of kyphotic deformity in ankylosing spondylitis 脊柱後凸合併強直性脊柱炎的外科治療

Keith luk (Hong Kong) 陸瓞驥 (香港 )

10:55 - 11:05 Hong Kong Minimal Invasive spinal surgery society 香港微創脊椎手術學會 : Retrospective review of thoracic myelopathy胸椎脊髓病的回顧性調查

Joshua Ko (Hong Kong) 高天祐 (香港 )

11:05 - 11:15 Guangdong spinal surgery association 廣東省醫學會脊柱外科學分會 : surgical strategy for multi-level cervical spondylotic myelopathy 長節段頸椎病的治療策略

zeng-Hui Wu (China) 吳增暉 (中國大陸 )

11:15 - 11:25 Chinese association of spine and spinal Cord中國康復醫學會脊柱脊髓專業委員會 : Reconstructive surgery for upper cervical spine tumors上頸椎腫瘤切除後穩定性重建

zhong-Jun liu (China) 劉忠軍 (中國大陸 )

11:25 - 11:40 Panel discussion & Q&a 小組討論及問答

11:40 - 12:30 Session ii: Pediatric spinal deformity management 第二節：小兒脊柱側彎的治療

moderators:Hui liu (China), Keith luk (Hong Kong)劉輝 (中國大陸 )，陸瓞驥 (香港 )

11:40 - 11:50 Guangdong spinal surgery association 廣東省醫學會脊柱外科學分會 : The diagnosis and management of early onset scoliosis 早發性脊柱側凸（eos）的診斷與處理

Yan Peng (China) 彭焰 (中國大陸 )

11:50 - 12:00 Guangdong spinal surgery association 廣東省醫學會脊柱外科學分會 : The significance of saggital balance during correction of degenerative 矢狀面平衡在退變性脊柱側凸矯正術中的意義

an-Jing liang (China) 梁安靖 (中國大陸 )

12:00 - 12:10 Guangdong spinal surgery association 廣東省醫學會脊柱外科學分會 : surgical results of scoliosis with type-1 neurofibromatosis nf-1 合併脊柱側凸手術治療效果分析

Yan Peng (China) 彭焰 (中國大陸 )

12:10 - 12:20 Hong Kong orthopaedic association, spine Chapter 香港骨科醫學會脊柱分會 : Principles of surgical management of idioplathic scoliosis 特發性脊柱側彎的外科治療原則

Keith luk (Hong Kong) 陸瓞驥 (香港 )

12:20 - 12:30 Panel discussion & Q&a 小組討論及問答

12:30 - 14:00 lunch 午休 (Venue: Hall 2, G/f)

aSSoCiation ColloQuium ii

DaY 1 friday, September 25, 2015Conference Hall 2Program Chairman: zhong-Jun liu (China) A

M

mandarin Session


CroSS-Strait ortHoPaeDiC DaY海峽兩岸脊柱日

time agenDa SPeaKer14:00 - 15:00 Session iii: Spinal infection management

第三節：脊椎感染的治療moderators:Yong Hai (China), Yen-Yao li (taiwan)海涌 (中國大陸 )，李晏瑤 (臺灣 )

14:00 - 14:10 Hong Kong orthopaedic association, spine Chapter 香港骨科醫學會脊柱分會 : Management of pyogenic spinal infection脊柱化膿性感染的治療

Kam-Kwong Wong (Hong Kong) 黃淦剛 (香港 )

14:10 - 14:20 Taiwan spine society台灣脊椎外科醫學會 : Comparison of minimal access and traditional anterior spinal surgery in managing infectious spondylitis: a minimum 2 year follow-up 微創或傳統前位脊椎手術以治療感染性脊椎炎之比較 - 追蹤二年以上

Meng-Huang Wu (Taiwan) 吳孟晃 (臺灣 )

14:20 - 14:30 Chinese association of spine and spinal Cord 中國康復醫學會脊柱脊髓專業委員會 : Posterior only approach for spine Tb 一期後路入路治療脊柱結核

Yong Hai (China) 海湧 (中國大陸 )

14:30 - 14:40 Taiwan spine society台灣脊椎外科醫學會 : The trend of treatment for infectious spondylitis in past two decades近年對處理感染性脊椎炎之治療趨勢

Tze-Hong Wong (Taiwan) 王子康 (臺灣 )

14:40 - 14:50 Taiwan spine society台灣脊椎外科醫學會 : Treatment outcomes of fungal vertebral osteomyelitis: a case series study andliterature review 脊椎黴菌感染之治療成效

Yen-Yao li (Taiwan) 李晏瑤 (臺灣 )

14:50 - 15:00 Panel discussion & Q&a 小組討論及問答15:00 - 15:50 Session iv: minimal invasive spinal surgery

第四節：微創脊椎手術moderators:Wen-Hsiang Chou (taiwan),Jwo-luen Pao (taiwan) 周溫祥 (臺灣 )，鮑卓倫 (臺灣 )

15:00 - 15:10 Hong Kong Minimal Invasive spinal surgery society香港微創脊椎手術學會 : Percutaneous endoscopic lumbar diskectomy: technical pearls to tackle different types of prolapse經皮內鏡腰椎椎間盤切除術：應對不同類型突出的技術要點

Ying-Kei Chan (Hong Kong) 陳英琪 (香港 )

15:10 - 15:20 Taiwan spine society臺灣脊椎外科醫學會 : Minimally invasive approach for revision lumbar spine surgery 腰椎重建手術的微創入路

Jwo-luen Pao (Taiwan) 鮑卓倫 (臺灣 )

15:20 - 15:30 Taiwan spine society臺灣脊椎外科醫學會 : Compared the use of ultrasonic bone scalpel versus traditional method for decompression in degenerative lumbar spondylolisthesis and stenosis 腰椎退變性滑脫合併椎管狹窄：應用超聲骨刀 Vs傳統減壓

Wen-Hsiang Chou (Taiwan) 周溫祥 (臺灣 )

15:30 - 15:40 Taiwan spine society臺灣脊椎外科醫學會 : Modified mini-TlIf with noWa new per cutaneous screws system 改良微創 TlIf諾娃經皮螺釘系統的新技術

Chia-Hsiao Kuo (Taiwan)郭家孝 (臺灣 )

15:40 - 15:50 Panel discussion & Q&a 小組討論及問答15:50 - 16:05 Coffee break 茶歇16:05 - 17:00 Session v: Cervical spinal surgery

第五節：頸椎手術moderators:Haw-Chou lee (Singapore), Yan Peng (China)李浩洲 (新加坡 )，彭焰 (中國大陸 )

16:05 - 16:15 Guangdong spinal surgery association 廣東省醫學會脊柱外科學分會 : Coblation necleoplasty for the treatment of cervical spondylotic disease 等離子消融在頸椎病的應用

Jian li (China) 李健 (中國大陸 )

16:15 - 16:25 Chinese association of spine and spinal Cord 中國康復醫學會脊柱脊髓專業委員會 : self-designed posterior atlas polyaxial lateral mass screw plate fixation for unstable atlas fracture自製後路釘板系統治療寰椎不穩定骨折

Da-Geng Huang (China) 黃大耿 (中國大陸 )

16:25 - 16:35 Guangdong spinal surgery association 廣東省醫學會脊柱外科學分會 : Revision strategy for failed surgery of occipital-cervical region枕頸部手術失效的原因和翻修策略

zeng-Hui Wu (China) 吳增暉 (中國大陸 )

16:35 - 16:45 Chinese association of spine and spinal Cord: 中國康復醫學會脊柱脊髓專業委員會 : C1-2 minimal invasive posterior approach to C1-2 fracture and dislocation fixation 治療 C1-2骨折脫位的後路微創入路

Huan Wang (China) 王歡 (中國大陸 )

16:45 - 16:55 Panel discussion & Q&a 小組討論及問答16:55 - 17:00 summary & Closing Remarks 總結及閉幕辭 zhong-Jun liu (China)

劉忠軍 (中國大陸 )


DaY 1 friday, September 25, 2015Conference Hall 2Program Chairman: zhong-Jun liu (China) P

M

mandarin Session


aSia PaCifiC neuroSurgerY aPeX

time agenDa SPeaKer08:20 - 08:30 Welcome Introduction Kang lu (Taiwan)08:30 - 09:45 Session i: Korean Spinal neurosurgery Society moderators:

zan Chen (China), David Sun (Hong Kong)

08:30 - 08:40 Case Presentation: Minimally invasive lateral lumbar interbody fusion Kyeong-sik Ryu (south Korea)

08:40 - 08:50 lecture: Minimally invasive lateral interbody fusion seung-Won Park (south Korea)

08:50 - 08:55 Q&a

08:55 - 09:05 Case Presentation: Posterior reconstruction of osteoporotic thoracolumbar kyphosis

Jung-Kil lee (south Korea)

09:05 - 09:15 lecture: Posterior reconstruction of osteoporotic thoracolumbar kyphosis Keung-nyun Kim (south Korea)

09:15 - 09:20 Q&a

09:20 - 09:35 experts' feedback Tzu-Yung Chen (Taiwan), zan Chen (China), David sun (Hong Kong), Toshihiro Takami (Japan)

09:35 - 09:45 Conclusion seung-Won Park (south Korea)

09:45 - 10:00 Coffee Break10:00 - 11:15 Session ii: Japanese Society of Spinal Surgery moderators:

Xiao-ming Che (China), Keung-nyun Kim (South Korea)

10:00 - 10:10 Case Presentation: Transoral removal of retroodontoid massive pseudotumor Toshiyuki Takahashi (Japan)

10:10 - 10:20 lecture: surgical managements of intramedullary vascular tumors: tips and toes Kazutoshi Hida (Japan)

10:20 - 10:25 Q&a

10:25 - 10:35 Case Presentation: Coextence of intracranial and spinal huge tumors: how to manage?

satoshi Yamaguchi (Japan)

10:35 - 10:45 lecture: surgical management of spinal intramedullary tumors: radical and safe strategy for benign gliomas

Toshihiro Takami (Japan)

10:45 - 10:50 Q&a

10:50 - 11:05 experts' feedback Chih-Ju Chang (Taiwan), Xiao-Ming Che (China), Keung-nyun Kim (south Korea), Daniel ng (Hong Kong)

11:05 - 11:15 Conclusion Kazutoshi Hida (Japan)11:15 - 12:30 Session iii: Chinese Congress of neurological Surgeons moderators:

Joseph mK lam (Hong Kong), Jung-Kil lee (South Korea)

11:15 - 11:25 Case Presentation: Upper cervical spine tumor Xiao-Ming Che (China)

11:25 - 11:35 lecture: The treatment of basilar invagination accompanied with atlanto-axial dislocation

zan Chen (China)

11:35 - 11:40 Q&a

11:40 - 11:50 Case Presentation: Clinical application of oblique lateral interbody fusion (olIf) for lumbar degenerative scoliosis: a preliminary report

Hai-long feng (China)

11:50 - 12:00 lecture: Under microscope unilateral approach with tubular retractore for bilateral decompression of lumbar spinal stenosis

Chun-Mei Chen (China)

12:00 - 12:05 Q&a

12:05 - 12:20 experts' feedback Joseph MK lam (Hong Kong), Jung-Kil lee (south Korea), Toshiyuki Takahashi (Japan), Jau-Ching Wu (Taiwan)

12:20 - 12:30 Conclusion and Group Photo zan Chen (China)



DaY 2 Saturday, September 26, 2015Conference Hall 2 Program Chairman: Kang lu (taiwan) A

M

english Session


aSia PaCifiC neuroSurgerY aPeX

time agenDa SPeaKer

14:00 - 15:15 Session iv: taiwan neurosurgical Spine Society moderators: Wai-man Hung (Hong Kong), Satoshi Yamaguchi (Japan)

14:00 - 14:10 Case Presentation: Circumferential fusion for oPll Chih-Ju Chang (Taiwan)

14:10 - 14:20 lecture: Cervical disc arthroplasty Jau-Ching Wu (Taiwan)

14:20 - 14:25 Q&a

14:25 - 14:35 Case Presentation: Combined soPs and TlIf for spinal sagittal deformity

Tzu-Yung Chen (Taiwan)

14:35 - 14:45 lecture: Minimally invasive spine surgery: present and future Yung-Hsiao Chiang (Taiwan)

14:45 - 14:50 Q&a

14:50 - 15:05 experts' feedback Chun-Mei Chen (China), Wai-Man Hung (Hong Kong), Kyeong-sik Ryu (south Korea), satoshi Yamaguchi (Japan)

15:05 - 15:15 Conclusion Kang lu (Taiwan)


15:30 - 17:00 Session v: Hong Kong neurosurgery Spine interest group, Hong Kong neurosurgical Society

moderators: Kazutoshi Hida (Japan), Seung-Won Park (South Korea)

15:30 - 15:40 lecture: olIf and DlIf Joseph MK lam (Hong Kong)

15:40 - 15:50 Case Presentation: Micro-endoscopic lumbar discectomy Wai-Man Hung (Hong Kong)

15:50 - 16:00 lecture: Minimally invasive approach to intradural extra medullaryspine tumor

Daniel ng (Hong Kong)

16:00 - 16:10 Case Presentation: Robotic spine Clarence leung (Hong Kong)

16:10 - 16:20 Intraoperative monitoring - is it facilitating or hindering spine surgery? David sun (Hong Kong)

16:20 - 16:30 Q&a

16:30 - 16:50 experts' feedback Yung-Hsiao Chiang (Taiwan), Hai-long feng (China), Kazutoshi Hida (Japan), seung-Won Park (south Korea)

16:50 - 17:00 Conclusion David sun (Hong Kong)


DaY 2 Saturday, September 26, 2015Conference Hall 2Program Chairman: Kang lu (taiwan) P

M

english Session


aSia PaCifiC Pain management DaY

time agenDa SPeaKer

08:20 - 08:30 Welcome Introduction David sun (Hong Kong)

08:30 - 10:10 Session i: neuropathic Pain moderators:madhuri lokapur (india),David Sun (Hong Kong)

08:30 - 08:50 Indian society for study of Pain: Understanding nociceptive & neuropathic pain & their importance in clinical practice

Muralidhar Joshi (India)

08:50 - 08:55 Q&a

08:55 - 09:15 Indian society for study of Pain: Post-herpetic neuralgia

Muralidhar Joshi (India)

09:15 - 09:20 Q&a

09:20 - 09:40 Hong Kong Pain society: Trigeminal neuralgia

David sun (Hong Kong)

09:40 - 09:45 Q&a

09:45 - 10:05 Hong Kong Pain society: Pharmacological treatment of neuropathic pain

steven Wong (Hong Kong)

10:05 - 10:10 Q&a


10:40 - 12:00 Session ii: neuropathic Pain moderators:David Sun (Hong Kong), Steven Wong (Hong Kong)

10:40 - 11:00 Hong Kong Pain society: Pain interventions in neuropathic pain

Carina li (Hong Kong)

11:00 - 11:05 Q&a

11:05 - 11:25 Hong Kong Pain society: Dorsal column stimulation

Kwan-ngai Hung (Hong Kong)

11:25 - 11:30 Q&a

11:30 - 11:50 Indian society for study of Pain: Pump implant for intractable neuropathic pain

Madhuri lokapur (India)

11:50 - 11:55 Q&a

11:55 - 12:00 summary & Closing Remarks David sun (Hong Kong)


DaY 3 Sunday, September 27, 2015Conference Hall 2Program Chairman: David Sun (Hong Kong) english Session


innovative non-CliniCal ColloQuium

DaY 1 friday, September 25, 2015Conference Hall 3Program Chairman: Chung-Chek Wong (malaysia) A

M

english Session

gloBal innovative anD ControverSial SPine SurgerY Summit

time agenDa SPeaKer

08:20 - 09:25 Plenary Session - Spine concepts(This session is held in Plenary Hall. Please refer to Page 50 for detail program.)



10:15 - 11:35 Session i: Practice management moderators:naresh Kumar (Singapore), maarten Spruit (netherlands)

10:15 - 10:30 What is the use of scoliosis registry Venugopal Menon (oman)

10:30 - 10:45 Health technologies assessment for spine surgeons Jahangir asghar (United states)


10:55 - 11:10 Patient database management system - KeoPs Philippe Roussouly (france)

11:10 - 11:25 Cognitive behavioural therapy for back pain Maarten spruit (netherlands)



12:10 - 13:00 Session ii: Complex spine problem moderators:venugopal menon (oman), Chung-Chek Wong (malaysia)

12:10 - 12:30 Updates in pediatric spine deformity Jahangir asghar (United states)

12:30 - 12:50 new directions in adult complex spine surgery: from spinopelvic balance to the seattle spine team approach

Rajiv sethi (United states)





DaY 1 friday, September 25, 2015Conference Hall 3Program Chairman: Chung-Chek Wong (malaysia) P

M

english Session

gloBal innovative anD ControverSial SPine SurgerY Summit

time agenDa SPeaKer

14:00 - 15:20 Plenary Session - Spine updates (This session is held in Plenary Hall. Please refer to Page 51 for detail program.)


15:50 - 17:00 Session iii: Private practice, stand & deliver: your money or your life

moderators:Jose manuel ignacio (Philippines),Seong-Hoon oh (South Korea)

15:50 - 16:30 The medical precinct eleanor Clausen (australia),Julie fallon (australia)


16:50 - 17:00 final Q&a & Grand summary



DaY 2 Saturday, September 26, 2015Conference Hall 3Program Chairman: Chung-Chek Wong (malaysia) A

M

english Session

inStrumentS anD imPlant DeSigning DeveloPment WorKSHoP

time agenDa SPeaKer

08:20 - 08:30 Welcome Introduction Chung-Chek Wong (Malaysia)

08:30 - 09:10 Plenary Session - How to get involved in implant/instrument development(Venue: Plenary Hall)

moderators:mohd Hisam muhamad ariffin (malaysia), ajoy Shetty (india)

08:30 - 08:45 latest development in spinal biomechanical lab testing Jahangir asghar (United states)

08:45 - 09:00 Medical device innovation in the era of cost cutting & evidence-based medicine

Hassan serhan (United states)



09:40 - 11:50 Session i: experience sharing in surgeon and industrial partners perspectives

moderators:Sigurd Berven (united States), Chung-Chek Wong (malaysia)

09:40 - 10:00 I have a great idea, how do I proceed? Jose Manuel Ignacio (Philippines)

10:00 - 10:15 aosTK: an introduction Implant and instruments design / development

Maarten spruit (netherlands)


10:25 - 10:45 Intellectual property: patent application, process & implications Hassan serhan (United states)

10:45 - 11:00 Impant develpement: a surgeon's journey Christopher Cain (United states)

11:00 - 11:15 Product development cycle: napkin sketch to clinic Hassan serhan (United states)


11:25 - 11:40 The oeM process of implant and instrument in China Michael li (China)



12:05 - 13:00 Session ii: Debate on intra-operative neuromonitoring moderators:Hubert labelle (Canada),Yong Qiu (China)

12:05 - 12:25 Intra-operative neuromonitoring - I can't live without it Mohd Hisam Muhamad ariffin (Malaysia)

12:25 - 12:45 Intra-operative neuromonitoring - its an nuisance zhao-Min zheng (China)





DaY 2 Saturday, September 26, 2015Conference Hall 3Program Chairman: Chung-Chek Wong (malaysia) P

M

english Session

innovative WorKSHoP for PuSHing tHe frontier of SurgiCal eDuCation

time agenDa SPeaKer

14:00 - 14:40 Plenary Session -Deformity surgery - anterior or not?(Venue: Plenary Hall)

moderators:Yong Hai (China),lawrence Haber (united States), ronald tangente (Philippines)

14:00 - 14:15 The role of anterior surgery in adult deformity sigurd berven (United states)

14:15 - 14:30 Minimally invasive lateral options for spinal deformities:utilizing minimally invasive technology to avoid anterior surgery

Rajiv sethi (United states)



15:25 - 17:00 Session iii: Pushing the frontier of surgical education moderators:mohd Hisam muhamad ariffin (malaysia),naresh Kumar (Singapore)

15:25 - 15:40 The surgeon educator bryan ashman (australia)

15:40 - 15:55 The scoliosis week experiences Venugopal Menon (oman)


16:10 - 16:25 Impactful audiovisual presentation Richard emery (france)

16:25 - 16:40 How to design and run a surgery video seminar seong-Hoon oh (south Korea)

16:40 - 16:55 Panel discussion

16:55 - 17:00 final Q&a & Grand summary



DaY 3 Sunday, September 27, 2015Conference Hall 3Program Chairman: Chung-Chek Wong (malaysia) english Session

HoW to SuCCeSSfullY Craft anD CommuniCate Your BranDS aS a Surgeon

time agenDa SPeaKer

08:20 - 08:30 Welcome Introduction Master the brand called YoU

Chung-Chek Wong (Malaysia)

08:30 - 11:30 master the brand called You™ - how to successfully craft and communicate your brand as a surgeon

08:30 - 10:30 The art and science of building a brand

brenda bence (singapore)

What "Personal branding" mean for surgeons

The benefits of self-branding as a medical professional

Critical steps to take control of your brand

Getting clarity around what your brand stands for right now

How to effectively communicate your brand as a surgeon

Keys to levering social media as a medical professional

Getting into action: the secret to success

Your brand legacy



11:00 - 11:15 back from spine training: where do I go from here? Jose Manuel Ignacio (Philippines)

11:15 - 11:20 Discussion & Q&a

11:20 - 11:30 Grand summary Chung-Chek Wong (Malaysia)


I n DU sTR Ial PaRTn e R s

Beijing fule Science &technology Development Co., ltdno. 50, Mafang West Industry zone,Pinggu District, 101204 beijingChina+86 1060999862fulekeji.com/english/index.asp

founded in april of 1996, beijing fule science & Technology Development Co., ltd. (hereinafter referred to as beijing fule) is a leading contract manufacturer of high-performance orthopaedic products. We specialize in spine & Trauma products, along with fast service of a dynamic and experienced team, beijing fule is driven to utilize superior service and technology to achieve better life.

Beijing greenland Co., ltd5e-Room, building a,Jinyuan Commercial Center, Haidian District, 100097 beijingChina+86 1088864114www.greenlandmed.com

founded in 2003, with Iso and Ce approved, beijing Greenland Co., ltd. is one of the leading manufacturers and exporters that undertakes the business of high-quality medical products for Pain Clinic / orthopedics (Minimally Invasive spine surgery) in China, asia.spine surgery Products: bipolar Rf spine ablation Unit (Rf Generator) & Rf electrodes, Plasma Unit & Plasma electrodes, Rf spine needles, etc. for Pain Clinic / orthopedics (Minimally Invasive spine surgery for lumbar Vertebra / Cervical Vertebra).

Brainlab ltd Unit 2102, The Hennessy, 256 Hennessy Road, Wan ChaiHong Kongwww.brainlab.com

brainlab develops, manufactures and markets software-driven medical technology, enabling access to advanced, less invasive patient treatments.brainlab technology powers treatments in radiosurgery as well as numerous surgical fields including neurosurgery, orthopedic, enT, CMf, spine and trauma. founded in Munich in 1989, brainlab has over 9000 systems installed in about 100 countries.

Carl zeiss meditec agGoeschwitzer strasse 51-52, 07745 JenaGermany+49 36412200 www.zeiss.com/med

a modern microscope for spinal surgery must fulfill four essential criteria: excellent visual clarity over long working distances, an extended reach to accommodate large surgical work spaces, comfortable positioning flexibility for both surgeon and assistant in face-to-face configurations, and fast oR setup. surgical microscopes from zeIss excel in all of these areas.

DePuy SynthesRoom 1001-1009, 10/f, Tower 2,Grand Century Place, 193 Prince edward Road West, Mongkok, KowloonHong Kong+852 27386000depuysynthes.com

DePuy synthes spine team, companies of Johnson & Johnson, provides solution for treating aging spine, spine deformity and degenerative spine.DePuy synthes spine team, companies of Johnson & Johnson, serves the healthcare industry.

DKSH Hong Kong limited23/f, Tower a, southmark,11 Yip Hing street, Wong Chuk HangHong Kong+852 28950888www.dksh.hk / www.dksh.com

DKsH is the leading Market expansion services provider with a focus on asia. as the term "Market expansion services" suggests, DKsH helps other companies and brands to grow their business in new or existing markets. Publicly listed on the sIX swiss exchange since March 2012, DKsH is a global company headquartered in zurich. With 750 business locations in 35 countries – 720 of them in asia – and 27,600 specialized staff, DKsH generated net sales of CHf 9.8 billion in 2014. The company offers a tailor-made, integrated portfolio of sourcing, marketing, sales, distribution and after-sales services. It provides business partners with expertise as well as on-the-ground logistics based on a comprehensive network of unique size and depth. business activities are organized into four specialized business Units that mirror DKsH fields of expertise: Consumer Goods, Healthcare, Performance Materials, and Technology. In 2015, DKsH celebrates its 150th anniversary. With strong swiss heritage, the company has a long tradition of doing business in and with asia, and is deeply rooted in communities and businesses across asia Pacific.


Klarity medical & equipment Co., ltd.2/f 1st bldg., Guangzhou scienTech Park,no. 9 lanyu 4th Rd., GeTDD, 510730 GuangzhouChina +86 2082068797 www.klarity-medical.com

Klarity is a world leader in the manufacture of thermoplastics and positioning devices for radiation therapy, rehabilitation and occupational therapy, orthopedics and other specialties.

medlane12 Chemin des Joncs 69570france+33 472521152www.medlane.com

MeDlane which has been created in 1989 is a french company. Medlane belongs to the leading companies in the field of surgical instruments and of sterilization containers.Medlane is at the forefront of the manufacturing of surgical instruments and sterilization containers. Its experience enables Medlane to offer more than 15,000 references.Thanks to its well-developed distribution network, to a complete range of high quality products, among which there are many registered trademarks.

medtronicblock 11, no. 3000 long Dong avenue, Pudong,201203 shanghaiChina +86 2120325888www.medtronic.com

Medtronic plc is the global leader in medical technology and improves the lives of millions of patients every year with its mission to “alleviate pain, restore health, and extend life”. While its principle executive offices are now based in Ireland, Medtronic’s operational headquarters remain in Minneapolis, Minnesota, where the company was founded over 60 years ago. Medtronic has a comprehensive product portfolio of medical devices across various business units, including but not limited to: Cardiac Rhythm Heart failure, Coronary and structural Heart, aortic and Peripheral Vascular, spinal and biologics, neuromodulation, surgical Technologies, neurovascular, Diabetes, surgical Innovations, and emerging Technologies.Chargzhou Kanghui Medical Innovation Co., ltd. is China’s leading manufacturer of orthopedic devices and has focused on the innovative exploration of spine, trauma and joint replacements. Kanghui Medical formally joined the world's leading medical technology company, Medtronic Inc., at the end of 2012. Currently, Kanghui Medical operates in 34 countries and regions all over the world, benefitting millions of patients across the globe.beijing libeier bio-engineering Institute Co., ltd. is a high-tech enterprise dedicated to the research, manufacture and sales of orthopedic implants and instruments. libeier offers trauma, spinal and external fixator products and has industry leading R&D strength, advanced production equipment, reliable quality assurance, and reaches across a number of international markets.

newtech international trading limitedRm 1903, Winning Centre, 29 Tai Yau street,san Po Kong, KowloonHong Kong+852 23233018

our company is distributing world-wide leading medical equipment and surgical instruments. our major products including:-• leica surgical Microscope - provide all kind of microscopes

for spine, neuro surgery, Vascular surgery ,enT and ophthalmology

• Richard Wolf - endoscope and Camera system for endoscopic surgery, including Vertebris lumbar Trans-extraforaminal & Interlaminar, arthroscopy for Knee / shoulder / elbow / foot / Hand / fingers / Toes

• TrueVision - 3D imaging system through a surgical microscope provide a 3D of surgical field for microsurgery

• stryker/berchtold - surgical operating lamp and operating Tables

Schmidt Biomedtech (HK) ltd20/f, Chinachem exchange square,1 Hoi Wan street, Quarry bayHong Kong+852 26208329www.schmidtbmt.com

Mazor Robotics is a leading innovator in spine surgery. Renaissance® Guidance system is the new generation surgical system. Its 3D imaging software helps surgeon create a surgical blueprint, while the Renaissance® guides surgical tools with up to 1.5mm accuracy. Therefore perform complicated spine procedures with increased accuracy and ease.schmidt is the HK distributor of Mazor. We also provide the oT equipment to facilitate the patient positioning and imaging issue.

Siemens Healthcare Sector 278, zhouzhu Road, Pudong new District,201318 shanghaiChina +86 2138895000www.siemens.com/healthcare

The siemens Healthcare sector is one of the world's largest suppliers to the healthcare industry and a trendsetter in medical imaging, laboratory diagnostics and medical information technology. siemens offers its customers products and solutions for the entire range of patient care from a single source – from prevention and early detection to diagnosis, and on to treatment and aftercare. by optimizing clinical workflows for the most common diseases, siemens also makes healthcare faster, better and more cost-effective. siemens Healthcare employs some 52,000 employees worldwide and operates around the world.


f looR P l an

name of eXHiBitorS

5b10 newTech International Trading limited

5b11 beijing Greenland Co., ltd

5D08 Klarity Medical & equipment Co., ltd.

5D16 DKsH Hong Kong limited

5e01 brainlab ltd

5e02 Carl zeiss Meditec aG

5e05 DePuy synthes

5f01 Medtronic

5f06 siemens Healthcare sector

5G01 schmidt bioMedTech (HK) ltd

5G05 Medlane

5G06 beijing fule science & Technology Development Co., ltd

Conference Hall 1 Plenary Hall

ConferenceHall 2

Internet & ChargingStation

Coffee Break Area

Faculty Lounge OrganizerOffice

ConferenceHall 3

Regi

stra

tion

Coun

ter

Entr

ance

5F06 5F015G

015E02

5E01

5B11

5B10

5G06

5G05 5E05

Sales Lounge

OfficialContractor Office

5D16 5D08

Hall 2(Lunch Venue)

• Paper Presentation Area• Participant

Lounge


aC K noWle DGe M e nT

The organizing Committee of spine summit asia Pacific – Hong Kong 2015 wish to express their sincere appreciation to the following companies for their generous support in making the summit a great success:

SPeCial tHanKS to:


noTe s

Table of ConTenTs - Spine World Summit 2018 - Homesummit.spineworld.org/download/SSAP Program...

Documents

Transcript of Table of ConTenTs - Spine World Summit 2018 - Homesummit.spineworld.org/download/SSAP Program...