T cell ontology Revision
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Transcript of T cell ontology Revision
T cells
• 34 terms for types of T cell currently exist in the Cell Ontology.
• Broadly divided into immature and mature subsets, and into alpha-beta and gamma-delta subsets.
• The genus term ‘T cell’ is the parent term for all types of T cell.
T Cell Ontology
General issues for T cells– Introduce “thymocyte” to replace immature– Make definitions more precise. DN1 thymocyte - CD4- CD8- CD44+ CD25-
– Introduce the concept of naïve versus antigen experienced T cell - instead of “mature”
– Add additional T helper subsets - introduce transcription factors as part of the definition
Changes made– Collapsed immature and mature T cell into the T cell term– Made definitions more precise. DN1 thymocyte - CD4- CD8- CD44+ CD25-
– Added some generic terms such as helper T cell, memory T cell– A few cells have two parents– Expanded the development stages