T³ Book of Big Ideas

Clean-TechHealthcareEngineering &Physical SciencesComputer Science

© May 2012. Technion Research & Development Foundation.Technion - Israel Institute of Technology

Fifth Edition.

Welcome to Israel’s vanguard of innovation.

At T3, the technology transfer office of the Technion Research and Development Foundation, we make Technion’s cutting edge technologies available for commercialization.

Technion has made a global impact through its ability to transform breakthroughs in science, technology and engineering into successful commercial ventures. Today, Technion is home to three Nobel Prize laureates, and has been cited by global media as the leading cause of Israel’s remarkable development in science and technology.

T3 scouts for groundbreaking research in areas such as cleantech, life sciences, computer science, and nanotechnology. Innovations are made available to industrial partners, private investors, VC’s, angel groups and entrepreneurs through win-win alliances. T3 manages a portfolio of over 400 granted patents and over 900 pending patents.

Browse through the 5th edition of the T3 Book of Big Ideas and discover the latest Technion innovations available for commercialization.

We look forward to welcoming you to our strong community of entrepreneurs, investors, incubators, VC’s and angel groups that have benefitted from the impact of Technion’s excellence on the world of tomorrow.

Clean-TechHealthcareEngineering &Physical SciencesComputer Science

2012

2Contents

Clean-Tech

Healthcare

Energy

CHM-0496 Ultra-rapid texturing of silicon for solar panel productionCHM-1084 Silicon air batteriesCHM-8013 Novel coolant for corrosion-protection of magnesium alloy engine partsENE-0980 Fan and ducted-fan performance enhancements using dielectric barrier discharge plasma actuatorsENE-0985 Novel hydrogen production and storage methodENE-1017 Solar voltage amplifierENE-1032 Tandem electrolyte fuel cellENE-1053 A liquid desiccant system for cooling, dehumidification and air conditioning powered by solar or waste heatENE-1167 Autonomous natural gas reformer for on-demand and on-site hydrogen generationENE-1191 Engineering of a non-lethal novel electron transfer pathway into PSII as a step towards

biological energy production from photosynthetic organismsENE-1229 Blowing & Pulsed blowing flow control performance prediction on a vertical axis wind turbineENV-0935 Piezo-hydraulic compressor/pressure oscillator for cryogenics and other applicationsMAE-1029 Simplified fuel atomizationCHM-1272 Novel transparent conducting electrodes (TCOs)

Environmental

ENV-0798 Method and device for burning of sewage sludgeENV-1072 Remote pollution monitoring schemeENV-1213 Pig manure treatment processENV-1247 Methods, process and unit for separation, cleaning of flue gases and microalgae cultivationENV-1294 Sonic and ultra sonic augmentation of spray tower and cyclone scrubbers for gas and particles removalCHM-1202 Low-cost aerocellulose production; All-cellulose reinforced aerocellulose composites

Water

ENV-1135 Catalytic cloths for nitirate and nitrite removal from waterWAT-0526 Bacterial DNA fingerprint detectionWAT-0616 Chemical exposure measurement device (polymeric film sensor for polycyclic aromatic hydrocarbons)WAT-0829 Technique for catalytic oxidizing of dissolved matter in water by using adsorbent and nanocatalystsWAT-0848 ROAKs for the capture and concentration of bacteriaWAT-1078 Biological brine denitrificationWAT-1261 A cost effective physico-chemical treatment process for removal of nitrogen and

phosphorus species from recirculated aquaculture systems (RAS)COM-1394 Aquatic event detection algorithm

Cell/Tissue Therapy

COM-1001 3D texture synthesis and fittingCTT-0739 Medical scaffold, methods of fabrication and uses thereofCTT-0744 Natural acellularized cardiac extracellular matrix for tissue engineeringCTT-0838 Mesoscale bioactive 3D electrospun scaffold for bone repairCTT-0895 3D vascularized pancreatic islets - for islets transplantationCTT-1003 Methods for promoting cell transfection in vivo (ultrasound)CTT-1023 Layered hydrospinning for the production of tissue engineering scaffoldCTT-1164 Therapeutic use of modified Endothelial and Endothelial Progenitor Cells (EPCs)CTT-1311 Composite biomaterials for cardiac tissue engineeringCTT-1036 Ultrasound-mediated drug deliverySTM-0652 Methods of preparing feeder cells-free, xeno-free human embryonic stem cells and stem cell cultures

Diagnostics

DIA-0845 Concomitant analysis of salivary tumor markers – A new diagnostic tool for oral cancerDIA-0887 Method and kits for diagnosis of schizophreniaDIA-1061 Detection of ABCG2 activity using OH-bearing ImidazoacridinonesDIA-1092 A system for assessing chemosensitivity of lymphoblastic leukemia patients

to high dose MTX-containing combination chemotherapyDIA-1109 Improved diagnosis and immunotherapy of diseases based on analysis of the repertoire of serum soluble MHC-peptide antigensDIA-1121 Hand-held probe for in vivo tooth ESR dosimetryWAT-0526 Bacterial DNA fingerprint detectionWAT-0848 ROAKs for the capture and concentration of bacteria

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Drug Delivery

CTT-1036 Ultrasound-mediated drug deliveryDDL-1022 Nanoencapsulation of chemotherapeutic and other drugs in beta-casein micellesDDL-1026 Self-assembling capsidsDDL-1074 Compositions and methods for drug deliveryDDL-1160 OAK cochleates: Method and composition for a delivery platformDDL-1161 Cell-derived liposomes for drug-deliveryDDL-1279 Cell-cell fusion method with application in specific delivery of anti-nematode agents using proteins from the FF familyDDL-1293 Thermally-induced protein-polyphenol co–assemblies: beta lactoglobulin based nanocomplexes as protective nanovehicles for EGCGNUT-1051 Nano-complexes of beta-lactoglobulin and polysaccharides as vehicles for hydrophobic bioactive molecules

Drug Discovery: Agents reducing smoking-associated injury

DRS-0601 Methods, pharmaceutical compositions, oral compositions, filters and tobacco products for preventingor reducing tobacco smoke-associated injury in the aerodigestive tract of a subject

DRS-0911 Tobacco and tobacco packaging material for preventing or reducing tobacco-associated injury in the aerodigestive tractDRS-0933 Prevention or reduction of injury induced by tobacco related materials as smoke in the

aerodigestive tract with the copper chelator D-penicillamineDRS-0938 Prevention or reduction of biological injury induced by tobacco related materials as smoke and/or free radicals

and/or other inducers of oxidative stress through the MPTP/TSPO pathwayDRS-1087 Novel discovery presenting potent protector against the lethal effect of cigarette smoke

Drug Discovery: Anti-arrhythmic

DRS-0546 Tricyclic compounds and their uses as antiarrhythmic antifibrillatory and defibrillatory agents

Drug Discovery: Anti-inflammatory

DRS-1192 Novel class of antibiotics based on naturally lethal peptide sequence

Drug Discovery: Antibiotics

DRS-0673 Bifunctional antibiotics for targeting rRNA and resistance-causing enzymesDRS-0932 Novel antimicrobial agentsDRS-1006 OAKs: Novel library of antibiotics that mimic host defense peptidesDRS-1049 Design, synthesis and evaluation of novel Fluoroquinolone-Aminoglycoside hybrid antibioticsDRS-0607 Methods for the preparation of selectively-substituted corroles and new substituted corroles

Drug Discovery: Diabetes

DRS-1000 Overcoming insulin resistance state via alleviating GLUT4 repression caused by AHNAKDRS-1275 T-cell Receptor-Like (TCRL) antibodies directed to beta-Islets antigens presented by MHC class II

Drug Discovery: Hypolipidemic agents

DRS-0934 Metallocorroles: A novel compound fighting Atherosclerosis and high blood Cholesterol levels

Drug Discovery: Immunomodulators

DRS-0606 Methods and pharmaceutical compositions for immune deception, particularly useful in the treatment of cancerDRS-0655 An antibody fragment capable of modulating multidrug resistance

Drug Discovery: Neoplastic disorders

DRS-0607 Methods for the preparation of selectively-substituted corroles and new substituted corrolesDRS-0896 OAKs: Novel cancer-fighting mimics of host-defense peptidesDRS-0972 A systems approach for understanding and controlling the reactivity of immune cell populations against cancerDRS-1256 Novel antibodies which are able to bind soluble T-Cell receptor ligandsDRS-1315 Anticancer therapeutics via imidazoacridinone - and sunitinib-dependent lysosomal photodestruction

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Drug Discovery: Neurodegenerative diseases

DRS-0855 Heterocyclic derivatives, pharmaceutical compositions and methods of use thereofDRS-1019 Multifunctional catalytic antioxidants as cyto-protective and cyto-rescuing agents for chronic,

systemic, and neurodegenerative diseases

Drug Discovery: Orphan drugs

DRS-0816 Redesign of aminoglycosides for treatment of human genetic diseases caused by premature stop mutations

Drug Discovery: Phosphate regulators

DRS-0710 Compositions and methods for treating disorders associated with abnormal phosphate metabolism

Drug Discovery: Renal disorders

DRS-0764 Methods for treatment of Renal Failure

Medical Device

MAE-0680 Ion concentration sensorMED-0706 Electronic receptor and its application to controlling biological processesMED-0835 Fast retinal imaging by parallel projectionsMED-0867 Vectorial vortex mode transformation for a hollow waveguide using subwavelength structuresMED-0939 Cylindrical probe for ex-situ nuclear magnetic resonance spectroscopyMED-0991 In vivo flow-cytometryMED-1138 System and method for near surface surgery simulationMED-1152 Techniques for spectrally encoded endoscopyMED-1193 Microdevice for measuring water content in vivo and in vitroMED-1227 Multifocal ultrasound and its effect on biological tissues, in particular via ultrasound effect on biological membranesMED-1265 Method for the fabrication of hollow nanostracturesMED-1285 Manipulation of cells using combined opto-acoustic excitationMED-1289 A non-invasive method for monitoring thermal tissue treatmentMED-1299 Differential, calibration-free and reference-electrode-free CMOS ISFET for ions and pH measurementsMED-1303 Damaging cells using nanoparticles and short laser pulsesMED-1327 Method for optical stimulation and monitoring of neuronsMED-0949 Detection and diagnosis of chronic renal failure and kidney related diseases by Electronic NoseMED-0971 Non-contact holographic stimulation technology for next-generation vision restoration devicesCHM-0794 Ceramic coating on dental implant abutmentsCHM-1097 Microstructure control of ceramic matrix nanocompositesCOM-1158 Cancer diagnostic probeDIA-1121 Hand-held probe for in vivo tooth ESR dosimetry

Research Equipment

RES-0837 Floating electrode dielectrophoresis (feDEP)RES-0870 Electrical control over Antibody-Antigen bindingDDL-1074 Compositions and methods for drug deliveryMAE-1038 Acoustic particle focusingMED-1152 Techniques for spectrally encoded endoscopySTM-0652 Methods of preparing feeder cells-free, xeno-free human embryonic stem cells and stem cell cultures

Stem Cells

STM-0611 Methods of generating human cardiac cells and tissues and uses thereofSTM-0613 Differentiated human embryoid cells and a method for producing themSTM-0629 Endothelial cells derived from human embryonic stem cellsSTM-0630 Novel methods for the in vitro identification, isolation and differentiation of vasculogenic progenitor cellsSTM-0646 Method of dynamically culturing embryonic stem cellsSTM-0652 Methods of preparing feeder cells-free, xeno-free human embryonic stem cells and stem cell culturesSTM-0695 Engineering three-dimensional tissue structures using differentiating embryonic stem cellsSTM-0721 Growth and differentiation of human embryonic stem cells within three dimensional scaffoldsSTM-0722 Stem cell lines derived from delayed blastocyst culture and their usesSTM-0777 L6-IL6 receptor chimera supports the feeder layer-free culture of hESCsSTM-0789 Multicellular systems of pluripotent human embryonic stem cells and cancer cells and uses thereofSTM-0800 Isolation, purification and characterization of human embryonic stem cell and human fetal stem cell derived progenitors

and their differentiation into osteoblasts, chondrocytes and tendocytes

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HealthcareSTM-0801 Development of a dynamic process for the formation, propagation and differentiation of human embryoid bodiesSTM-0890 Adult stem cell-derived connective tissue progenitors for tissue engineeringSTM-0919 Ectodermal precursor cell line derived from human embryonic stem cellsSTM-0923 Identification and selection of cardiomyocytes during human embryonic stem cell differentiationSTM-0956 Embryonic and adult stem cells encapsulation for cell based therapy and cancerSTM-0988 Tissue engineering of vascularized cardiac muscle from human embryonic stem cellsSTM-1132 Suspension culture for undifferentiated human iPS cellsSTM-1136 Co-derivation and expansion of vasculogenic pericytes and endothelial cells from human ESCs and iPSSTM-1148 Pancreatic progenitor enrichment of hES cell culture by GLUT2 sortingSTM-1209 Novel method to generate Induced Pluripotent Stem (iPS) cells from keratinocytes from human plucked hair follicleSTM-1234 Suspension culture for undifferentiated human iPS cellsSTM-1283 Production of corneal tissue equivalents from human pluripotent stem cellsSTM-1290 Novel method to derive Extracellular matrix (ECM) from human embryonic stem cells (hESCs) and

human pluripotent stem cells (iPSCs) for regenerative medicine applicationsSTM-1330 Establishment of an hESC-based model as an ex vivo experimental and anti-cancer drug testing platformDDL-1161 Cell-derived liposomes for drug-delivery

Food and Nutrition

NUT-0833 Casein micelles for encapsulation of hydrophobic compoundsNUT-1015 Nano-Encapsulation of additives in Beta Casein assemblies for enrichment of foods, beverages and soft drinks including clear drinksNUT-1051 Nano-complexes of beta-lactoglobulin and polysaccharides as vehicles for hydrophobic bioactive moleculesNUT-1076 Addition of Prolactin to infant formulasNUT-1314 Maillard reaction-based nanocapsules for protection of water-insoluble nutraceuticals in clear drinks

Chemistry and Materials Science

CHM-0599 Efficient synthesis of a polyacene monomerCHM-0794 Ceramic coating on dental implant abutmentsCHM-0989 Low cost onsite generation of high purity oxygenCHM-1065 Barium titanate layer produced by aqueous suspension cathodic electrophoretic depositionCHM-1107 Facile production method of novel family of highly catalytic tridentate ligand complexesCHM-1159 Calixurenes – novel binding moleculesCHM-1198 Novel austenite stainless steel surface hardening treatmentCHM-1202 Low-cost aerocellulose production; All-cellulose reinforced aerocellulose compositeCHM-1236 Liquid droplet elastomerCHM-1251 Production of iodides from carboxylic acidsCHM-1272 Novel transparent conducting electrodes (TCOs)MAE-1046 Tactile feedback mechanismCHM-0496 Ultra-rapid texturing of silicon for solar panel productionCHM-0665 Copper CMP slurry compositionCHM-0708 Negative fullerene ion beams generation - method and apparatusCHM-0809 Exploitation of the ordering effect in liquids adjacent or confined by crystals to achieve novel structures

during liquid phase epitaxial growthCHM-1054 Novel p-dopant for organic semiconductorsCHM-1075 Seedless copper electroplating for Damascene processCHM-1097 Microstructure control of ceramic matrix nanocompositesCHM-1307 Electrospun metal and composite carbon-metal nanofibersCOM-0619 Gamma ray detectorENE-1167 Autonomous natural gas reformer for on-demand and on-site hydrogen generationMAE-0565 Voltage and light induced strains in porous crystalline materials

Measurement Methods and Systems

CHM-0676 Determination of thin film topographyCHM-0804 Seamless dual-mode ACPD non-destructive testing (NDT)COM-0884 Object distance and brightness estimationCOM-1139 Highly sensitive (single photon) detector for IR wavelengthsCOM-1157 Novel and powerful enhancement of measurement systems’ resolutionMAE-1038 Acoustic particle focusingCHM-0620 Variable lenslet arrayCHM-0802 Single sided probe for ESR imaging of semiconductorsCHM-1173 Direct and nondestructive chemical analysis of solid samplesCOM-1361 Superconducting nanowire single photon detector on a tip of an optical fiberCOM-0751 Automatic re-meshing from a 2D grid to a 3D model of genus-n based on topological analysisMAE-0730 Active detection of asymmetry in turbomachinery via asynchronous excitation

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Mechanical Systems

COM-0995 Ferroelectric stack actuator and shape control algorithmMAE-0632 Increased life for gas filters using acoustic fieldsMAE-0682 Electrostatic modulation of surface roughnessMAE-0730 Active detection of asymmetry in turbomachinery via asynchronous excitationMAE-0862 Highly sensitive, real-time structural monitoringMAE-0935 Miniature cryogenic compressorCHM-0804 Seamless dual-mode ACPD non-destructive testing (NDT)MAE-1029 Simplified fuel atomizationMAE-1038 Acoustic particle focusing

MEMS and NEMS

MAE-0565 Voltage and light induced strains in porous crystalline materialsMAE-0918 Low-friction molecular rotary motorsCOM-0636 Low Cost CMOS Thermal/IR Imaging SensorMAE-0682 Electrostatic modulation of surface roughness

Nanotechnology

CHM-0708 Negative fullerene ion beams generation - method and apparatusCHM-1034 Optical tweezersCHM-1054 Novel p-dopant for organic semiconductorsCHM-1097 Microstructure control of ceramic matrix nanocompositesCHM-1182 Novel durable tagging agentsCHM-1307 Electrospun metal and composite carbon-metal nanofibersCOM-0969 Membrane computing system and methodCHM-0501 Source of intense coherent high-frequency radiationCHM-0665 Copper CMP slurry compositionCHM-0989 Low cost onsite generation of high purity oxygenCHM-1084 Silicon air batteriesCHM-1202 Low-cost aerocellulose production; All-cellulose reinforced aerocellulose compositeCHM-1272 Novel transparent conducting electrodes (TCOs)MAE-0918 Low-friction molecular rotary motorsRES-0870 Electrical control over Antibody-Antigen binding

Networks and Communication

COM-0954 Polarization-multiplexing based passive optical networksCOM-0966 Blind reconstruction of multi-band analog signalsCOM-0970 Distorted signal recoveryCOM-0987 BENoC - Bus enhancement NoCCOM-1106 Compact and wideband tapered slot antenna for WPAN applicationsCOM-1122 Wideband analog to digital conversion and low rate baseband processingCOM-0500 Wavelength-selectable laserCOM-1295 Three-photon counting by three photon absorption

Optics and Lasers

CHM-0501 Source of intense coherent high-frequency radiationCHM-0620 Variable lenslet arrayCOM-1361 Superconducting nanowire single photon detector on a tip of an optical fiberCOM-0500 Wavelength-selectable laserCOM-0679 Passive Q-switch laserCOM-0734 Method for acquisition of video with enhanced resolutionCOM-0753 Optical noise-free microphoneCOM-0808 Efficient method of shaping a laser beamCOM-0945 LED-like photon pair sourceCOM-1050 Optical logic gateCOM-1158 Cancer diagnostic probeCOM-1186 Semiconductor two-photon laserMAE-0593 Space-variant subwavelength polarization gratingMAE-0614 Space-variant subwavelength dielectric gratingMAE-0634 Geometrical phase optical elements with space-variant subwavelength gratingsMAE-0647 System and method for producing a light beam with spatially varying polarizationMAE-0763 Space-variant polarization manipulation of a thermal emission

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Engineering & Physical SciencesPG

MAE-1112 Dilute nitride-based Quantum Well Infrared Photodetector (QWIP)MAE-1140 Nitrogen incorporation in atomic layer epitaxy growth of InAsN/GaAs quantum wellsMAE-1216 Tuneable XBn and nBn and PV IR detectorsMAE-1220 New active layer for GaAs-based lasersCHM-1034 Optical tweezersCOM-0910 Deep nanopatterning FIB technologyCOM-0954 Polarization-multiplexing based passive optical networksCOM-1157 Novel and powerful enhancement of measurement systems’ resolutionMAE-0565 Voltage and light induced strains in porous crystalline materials

Security

CIV-1108 Automated detection of tunnel excavationCOM-1181 Compact direction finding antennaMAE-0791 Autonomous control scheme for unmanned aerial vehicle flocksMAE-0877 Highly efficient spacecraft thruster - CAMILAMAE-1128 Agile kill vehicle against ballistic missilesCHM-1173 Direct and nondestructive chemical analysis of solid samplesCHM-1182 Novel durable tagging agentsMAE-0862 Highly sensitive, real-time structural monitoringMAE-1029 Simplified fuel atomization

Sensors

CHM-1173 Direct and nondestructive chemical analysis of solid samplesCHM-1238 Changing the properties of mechanical resonators by the means of electron beam induced depositionCOM-0619 Gamma ray detectorCOM-0636 Low Cost CMOS Thermal/IR Imaging SensorCOM-1102 CMOS -SOI-MEMS thermal sensors for THz imaginCOM-1253 CMOS-SOI-MEMS thermal antenna for THz thermal imagingCOM-1295 Three-photon counting by three photon absorptionMAE-1057 Self balancing motorcycleCHM-0620 Variable lenslet arrayCOM-0753 Optical noise-free microphoneCOM-1181 Compact direction finding antennaCOM-1304 Blackbody as a THz emitter and a THz measurement and characterization set-up based on blackbody and THz filtersMAE-0935 Miniature cryogenic compressorMAE-1112 Dilute nitride-based Quantum Well Infrared Photodetector (QWIP)MAE-1140 Nitrogen incorporation in atomic layer epitaxy growth of InAsN/GaAs quantum wellsMAE-1216 Tuneable XBn and nBn and PV IR detectors

VLSI and Semiconductors

CHM-0665 Copper CMP slurry compositionCHM-0802 Single sided probe for ESR imaging of semiconductorsCHM-0809 Exploitation of the ordering effect in liquids adjacent or confined by crystals to achieve

novel structures during liquid phase epitaxial growthCHM-1075 Seedless copper electroplating for Damascene processCHM-1153 Low-power vertical organic FET for low-cost large-area electronicsCHM-1407 Method for reversible and bistable switching of current in Electron Field EmissionCOM-0731 Gate diffusion inputs (GDI) circuit designCOM-0894 Improved transistor structuresCOM-0910 Deep nanopatterning FIB technologyCHM-0708 Negative fullerene ion beams generation - method and apparatusCOM-0945 LED-like photon pair sourceCOM-0987 BENoC - Bus enhancement NoCCOM-1050 Optical logic gate

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Computer ScienceSignal, Audio and Image Processing

COM-0751 Automatic re-meshing from a 2D grid to a 3D model of genus-n based on topological analysisCOM-0805 Image de-hazingCOM-0819 Hidden point removalCOM-0834 Recovering object visibility and structure in a scattering medium when using artificial illuminationCOM-0914 Robust silhouette tracking in video streamsCOM-0948 Efficient real-time acquisition of textured 3D videoCOM-1009 Asynchronous multi-band signal samplingCOM-1071 Texture and image interpolation using Markov modelsCOM-1080 Pinpoint MicrophoneCOM-1103 Complex barycentric coordinatesCOM-1117 Texture mapping of 3D models using casual imagesCOM-1119 Method for Images Saliency DetectionCOM-1154 Photonic-enabled ultra-high-speed RF analog-to-digital conversionCOM-1194 Speckle-Noise elimination in holographic projectionCOM-1304 Blackbody as a THz emitter and a THz measurement and characterization set-up based on blackbody and THz filtersCOM-1348 A new voltage controlled oscillator (VCO) topology for mm-wave integrated circuitsCOM-1365 A boost method for reconstruction algorithms in computed tomography, based on machine learningCTT-0838 Super resolution with no explicit motion estimation

Software and Algorithms

COM-1342 Supply Chain SimulatorCOM-0712 GeomCore - outstanding 3D graphicsCOM-0921 Optimal measurement technique of variable arraysCOM-0992 PIXSAR: Disk reclustering for faster XML databasesCOM-1030 Efficient and general Voronoi diagrams algorithmCOM-1035 Decision support tool for project managementCOM-1104 TCAM with fast error detectionCOM-1163 Optimal inspection of multidimensional regionsCOM-1282 Mitigation of Inter-Cell Coupling Effects in NAND Flash MemoryCOM-1394 Aquatic event detection algorithmCOM-0812 Monitoring multi-variate threshold functions over distributed data streamsCOM-1103 Complex barycentric coordinatesCOM-1150 Monitoring threshold functions over multiple nodes in distributed data sets

Web Sites and Web Technologies

COM-0779 Enriching document representation for information retrieval tasksCOM-0812 Monitoring multi-variate threshold functions over distributed data streamsCOM-0913 Protection of copyrighted material on the webCOM-0944 XPathL – logical language for integrating relational and XML databasesCOM-1067 Maximizing restorable throughput in MPLS networksCOM-1094 Advanced query language for social networksCOM-1150 Monitoring threshold functions over multiple nodes in distributed data setsCOM-1197 Social networks interaction protocolCOM-1204 Multi-core XML query processing

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Section

9

Clean-Tech

Energy

CHM-0496 Ultra-rapid texturing of silicon for solar panel productionThis innovative electrochemical process for silicon etching achieves a very high level of speed,efficiency and control while utilizing environmentally friendly materials. Silicon etching ortexturing has numerous applications including the production of microelectronics, productionof more effective solar panels or improved efficiency of reclaiming or reprocessing usedsilicon wafers.

CHM-1084 Silicon air batteriesNew metal-air batteries based on a silicon (Si) anode yield a capacity four times that ofconventional Zn-air batteries. We have solved the low conductivity problem of Si by usinghighly doped and metalized silicon. The novelty in this method is the use of a semiconductorsuch as Si for generation of energy. It is accomplished by utilizing silica as the reactionproduct with oxygen and a particular ionic liquid as electrolyte.

CHM-8013 Novel coolant for corrosion-protection of magnesium alloy engine partsThe trend towards reduced fuel consumption for automobiles has led to an increase in theuse of lighter metallic alloys in engines. Aside from weight reduction, magnesium alloys haveother advantages such as reduction in material cost and reduction of manufacturing costsdue to a more efficient manufacturing process. Special attention has been placed onmagnesium in the past ten years by the automobile industry worldwide. This innovativecoolant is designed specifically to protect magnesium alloys from corrosion while alsoprotecting all of the other metals in the engine for an efficient and long-lasting operation.

ENE-0980 Fan and ducted-fan performance enhancements usingdielectric barrier discharge plasma actuatorsThe presented invention pertains to personal, industrial and automotive cooling, ventilation,vacuuming and dust removal, inflating, etc. Other applications are computer componentcooling, propulsors for air vehicles and for airboats, air-cushion vehicles, airships and modelaircraft. The invention suggests using a dielectric barrier discharge plasma actuation in a newmethod in order to significantly improve the function of the applications mentioned above,and possibly decrease energy consumption wherever it is implemented.

TECHNOLOGY DESCRIPTION

Clean

-Tech


Clean-Tech > ENERGY

10CleanTech

Energy

ENE-0985 Novel hydrogen production and storage methodHydrogen is considered the ultimate fuel because of its extremely high energetic performancealong with clean reaction products (water or water vapor) of minimal ecological impact.However, the production, storage and transport of hydrogen are expensive, difficult andhazardous. The present invention demonstrates a novel method for the safe and easilycontrolled production, storage, and use of hydrogen. An innovative, unique method forhydrogen production via a self-sustained reaction between powdered aluminum and waterhas been developed. It is based on the activation of aluminum particles by an originalchemical treatment, enabling spontaneous reaction between aluminum and any type ofwater (pure water, tap water or sea water). Experiments at room temperature revealed acomplete reaction, generating approximately 1.24 liters of hydrogen per gram of aluminum.The method can be considered a very compact means of in-situ production of hydrogen andhydrogen storage, and may be combined in fuel cells and other power generation cycles.

ENE-1017 Solar voltage amplifierUnlike PV cells that are standalone systems designed to produce current, the technologyproposed here enables the addition of solar energy harvesting to any existing electricalsystem by connecting it in series. This novel concept of producing a solar voltage amplifier isapplicable to both small and large scale operations. It can be designed as an "inverse lamp"for small appliances for private use or for large scale power plants capable of creating vastamounts of electricity. The system conceived in the Technion for solar energy conversionconsists of an absorbing medium. Its population is inverted in a broad range of frequencies,corresponding to the solar spectrum. Once illuminated, the population of the majority of theenergy states may be inversed and as a result, according to the PASER concept, the mediummay act as a negative resistance component. In other words, power is transferred from thesolar radiation to the electrons via the medium. This can be visualized as a voltage amplifier.

ENE-1032 Tandem electrolyte fuel cellA new fuel cell (FC) is hereby proposed, constructed of two electrolytes instead of one withan interconnect. In this way, more robust FCs can be manufactured at lower costs. These FCswill be able to handle more fuels, at larger temperature ranges and with more robustnessin terms of the fuel quality. This novel design is expected to produce less leakage andoxidation problems.

Clean-Tech > ENERGY



11Clean

-Tech

Energy

ENE-1053 A liquid desiccant system for cooling, dehumidification andair conditioning powered by solar or waste heatGlobal warming, has led to an increase in air conditioning demand not only in hot andhumid climates such as in Mediterranean countries, but also in European countries with noair conditioning tradition. Electric utilities have their peak loads in hot summer days, andare often barely capable of meeting the demand, struggling with brown-out situations.With suitable technology, solar cooling can help alleviate, if not eliminate the problem. Wedeveloped a technology that is capable of using industrial waste heat or low-grade solarheat from low-cost flat plate collectors as their source of power, and have the potential toprovide both cooling and dehumidification, as required by the load.

ENE-1167 Autonomous natural gas reformer for on-demand and on-site hydrogen generationThe demand for hydrogen fuel cells is growing and consequently, the need for hydrogen isgrowing as well. We offer a natural gas autonomous membrane reformer for on-site and on-demand small-scale hydrogen production to facilitate hydrogen fuel-cell stack power generation.A working prototype of this compact, efficient and thermally-independent unit has shown muchpromise for autonomous generation of ultra-pure hydrogen from natural gas.

ENE-1191 Engineering of a non-lethal novel electron transfer pathway into PSIIas a step towards biological energy production from photosynthetic organismsModern science is searching for non-polluting ways to efficiently convert sunlight to energy.The inventors propose to construct a photocell that produces electricity and hydrogen, bothextremely valuable resources of energy, without producing chemical pollutants. Thetechnology involves the use of plants, seaweed or cyanobacteria, all organisms that produceenergy by photosynthesis. Technion researchers have discovered that by performing a specificmutagenic modification in a membrane protein, a cultivar can be used as an alternativeenergy source.

ENE-1229 Blowing & Pulsed blowing flow control performanceprediction on a vertical axis wind turbineWind turbines convert kinetic energy from the wind into mechanical energy in a process thatconsumes no fuel, and emits no air pollution. They are an increasingly large source ofcommercial electric power. The invention pertains to the control of dynamic stall on cross flowturbine blades, mainly in vertical axis wind turbines. While the existing technology can increasethe energy production only by a few percentages, the proposed technology has the ability todouble or even triple it.


Clean-Tech > ENERGYENVIRONMENTAL

12CleanTech

Energy

ENV-0935 Piezo-hydraulic compressor/pressure oscillator for cryogenicsand other applicationsPiezoelectricity is the ability of some materials to generate an electric potential in responseto applied mechanical stress, and vice versa. The invention is a device that provides pressureoscillations and/or compression to a gas. The piezohydraulic actuator developed at theTechnion is a hybrid device consisting of a piezoelectric actuator coupled to a hydraulicamplification system, which in turn drives a gas-compressing membrane. The device isbased on coupling a piezoelectric actuator to a hydraulic amplifier and replacing theconventional compressor piston by special impervious but flexible membranes, therebyinducing compression.

MAE-1029 Simplified fuel atomizationThe multitude of fuels required for different vehicle types causes various logistical problemsfor large organizations. This limitation could be solved by enabling spark ignition (gasoline)engines to use heavy fuels like kerosene and diesel. Unfortunately, all current approacheshave major disadvantages in terms of added weight, cost, or technical complexity. Ourmethod enables the use of diesel and kerosene fuels in gasoline vehicles with much lowermaterial and technical costs.

CHM-1272 Novel transparent conducting electrodes (TCOs)See ‘Chemistry and Materials Science’, page 43

Environmental

ENV-0798 Method and device for burning of sewage sludgeThe present technology represents an efficient method and device for incineration of sludgeand other waste biomass, based on an emulsification process, without prior dewatering. Inthe novel process proposed herein, the liquid sludge (with a humidity of up to 95-99%) istransformed into a fine disperse emulsion, consisting of fossil fuel and liquid sewage sludge,as well as an emulsifying agent, which is subsequently burnt in a furnace. This process isexpected to bring about a significant reduction of operation costs as compared to traditionalsludge incineration.

ENV-1072 Remote pollution monitoring schemeStricter air pollution regulations demand improved methods of enforcement. Our technologymakes on-road remote sensing of air pollution more cost-effective for authorities. It enablesover 4 times the coverage, more reliable readouts and lower cost of operation.

Clean

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Clean-Tech > ENVIRONMENTAL

13

Environmental

ENV-1213 Pig manure treatment processAnimal manure is a worldwide environmental problem, which is constantly increasing due tothe rising demand for meat. The current invention is a process integrating novel technologieswidely familiar from the waste treatment field together with the process for elimination ofammonia. This invention allows the optimization of waste treatment and pigs wastetreatment in particular while producing highly valuable products (energy and struvite).

ENV-1247 Methods, process and unit for separation, cleaning of flue gasesand microalgae cultivationThe presented technology may contribute to emitted CO2 capture and reduction inpower plant flue gas. The technology proposes a way to separate CO2 from otherflue gases and release it into reactors containing phytoplankton - an autotrophiccomponent of the plankton plant community, which obtains energy through theprocess of photosynthesis. As a result, CO2 pollution will be reduced, oxygen will bereleased to the atmosphere and biomass will be produced for varied uses.

ENV-1294 Sonic and ultra sonic augmentation of spray tower and cyclone scrubbersfor gas and particles removalCleaning of effluent gasses is very important and often legally required in most modernindustries. A wet scrubber is used to clean air, flue gas or other gases of various pollutantsand dust particles. Wet scrubbers work through the contact of target compounds orparticulate matter with the scrubbing solution. As regulatory demands continue to increase,it is becoming increasingly difficult to reach the mandated effluent contamination levels usingexisting technologies with reasonable operating costs. However, this technology can beadded to any existing scrubber system to increase the efficiency and reduce the amount ofcontaminants to required levels.

CHM-1202 Low-cost aerocellulose production; All-cellulose reinforcedaerocellulose compositeSee ‘Chemistry and Materials Science‘, page 43


Clean-Tech > WATER

14CleanTech

Water

ENV-1135 Catalytic cloths for nitrite and nitrate removal from waterThe increasing shortage of freshwater has highlighted the importance of reclaiming pollutedwells and protecting clean ones. Nitrates are one of the most problematic toxic groundwaterpollutants and are found in dangerous concentrations in many freshwater wells due to thewidespread use of fertilizers and the prevalence of nitrates in industrial waste. This novelmethod of nitrate removal converts the pollutant into nitrogen gas simply, efficiently andcost-effectively. Unlike other methods, these woven catalytic cloths work quickly, are easy tohandle and don't create polluted tertiary waterways with highly-concentrated nitrates.

WAT-0526 Bacterial DNA fingerprint detectionThis is a fast and highly accurate system for identifying the presence of bacteria, based on thedetection of its DNA sequence in the inspected medium. The technology is capable ofidentifying bacterial strains and can be easily adaptable to any bacteria. This new technologycan be used to automatically detect the presence of bacteria in food and water, as well as inbiological and medical samples.

WAT-0616 Chemical exposure measurement device (polymeric film sensorfor polycyclic aromatic hydrocarbons)The device will monitor exposure to chemicals and pollutants. It consists of a polymer filmthat, over an extended period, absorbs chemicals in the surrounding air. The accumulatedchemicals are measured using a fast optical inspection and screening procedure. The noveltyis a polymer film that is capable of collecting polycyclic aromatic hydrocarbons (PAHs) in anambient environment. The production cost of the proposed device is a few cents and theoptical inspection is completed in a matter of seconds.

WAT-0829 Technique for catalytic oxidizing of dissolved matter in waterby using adsorbent and nanocatalystsThe present invention relates to an adsorption/catalytic regeneration process for theregeneration of absorbing material such as active carbon, as well as for the treatment offluids containing undesired contaminants. In the method proposed, the spent adsorbentmaterial is regenerated in an advanced oxidation process using a nanocatalyst. Thistechnology also provides an efficient method for cleaning fluids containing organic andinorganic contaminants.



Clean-Tech > WATER

15Clean

-Tech

Water

WAT-0848 ROAKs for the capture and concentration of bacteriaThis is a method for the filtration and concentration of bacterial contaminants. Most water,food, and clinical samples usually contain bacteria below detection limits. This innovativetechnology proposes a system that assembles the bacteria into a larger mass. The systemexploits the affinity of microorganisms for peptidomimetic compound oligoacyllysines (OAKs),which were recently developed by the inventors as antimicrobial agents. OAKs are linked toan inert supporting material (resin), resulting in a resin-linked OAK (ROAK) that maintainshigh binding affinity for microbial cells.

WAT-1078 Biological brine denitrificationRecently developed membrane processes for water treatment inherently produce brine withproblematic disposal to the environment. There are no available solutions to the presentproblem of nitrogen compounds in brines. Technion researchers have developed a methodthat is suitable for large amounts of nitrogen using biological denitrification.

WAT-1261 A cost effective physico-chemical treatment process for removal of nitrogenand phosphorus species from recirculated aquaculture systems (RAS)The industry of fish growth for food is expanding rapidly, requiring novel fish growingsystems and technologies. The present invention describes a novel physic-chemical purelymethodology for the operation of intensive fish growing units (RAS), with respect to nutrient(N and P species) removal methods. The new technology is economical and reliable methodfor the removal of nitrogen and phosphorus dissolved species excreted by the fish.

COM-1394 Aquatic event detection algorithmIdentifying if and when a contamination event in a water distribution system occurred is ofgreat importance. Available software are either inflexible, lack probability updates accordingto existing conditions or "black boxed", and therefore hard to adapt and customize for aspecific water distribution system. We propose a novel algorithm that can be utilized bywater utilities worldwide as an add-on to existing on-line monitoring systems. The novelty ofthe system is threefold: By using a generic formulation of the problem the system may beused with various inputs; Very promising results are obtained by updating event probabilitiesas additional information is obtained; The univariate and multivariate functions in thealgorithm provide a unique, user friendly and precise evaluation of real time status of thewater distribution system.

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Cell/Tissue Therapy

COM-1001 3D texture synthesis and fittingCAD designers and CGI artists spend countless hours working with intricate 3D patterns. Ourtechnology enables the generation of seemingly-random 3D patterns from sample geometry.These patterns and scaffolds are designed to merge seamlessly with existing patternedgeometry. Possible uses include rapid prototyping (RP) of patterned objects such as boneimplants, automatic mending of damaged models and stronger RP models using efficientsupporting geometry.

CTT-0739 Medical scaffold, methods of fabrication and uses thereofThe present invention is a method for manufacturing medical scaffolds and their uses in bonerepair, and in dental and orthopedic surgeries. The scaffolds are composed of electrospunnanofibers that have a continuous or stepwise gradient of porosity, and an average pore sizeand weight per volume. The electrospun scaffold has a 3D structure of non-woven uniform,randomly oriented nanofibers with a diameter of 300-500 nm. The combination of theculture of osteogenic cells with an electrospun 3D scaffold provides an in vitro system thatsimulates the natural 3D environment capable of supporting bone repair. Note: available forcommercialization for applications from the neck down.

CTT-0744 Natural acellularized cardiac extracellular matrix for tissue engineeringThis invention is a cleaning procedure that results in a natural heart-derived cardiac ECM(extracellular matrix) scaffold for cardiac tissue engineering. A natural animal acellularizedcardiac ECM as described by the invention is the most suitable scaffold for cardiac tissueengineering: due to the acellularization process it does not evoke an immune response, yet itretains its original properties. The produced scaffolds were shown (in vitro) to supportcultures of muscles as well as embryonic stem cell-driven cardiac myocytes. This technologymay be used for various purposes in the field of cardiac tissue engineering such as cellsupport, tissue replacement and tissue remodeling.

CTT-0838 Mesoscale bioactive 3D electrospun scaffold for bone repairThe present invention relates to a 3D cubic mesoscale electrospun fibrous scaffold, suitablefor implantation in defective bone. The new technology offers nanoscale fibers (PCL) withembedded hydroxyapatite (HA) particles. The combination of electrospun fibers at thenanometric scale and larger mesoscale HA particles imitates the natural structure of bonematrix. This mesoscale scaffold, combined with ceramics and growth factors, constitutes theoptimal scaffold to support proliferation and osteogenic differentiation as well asvascularization. It provides a promising surgical tool for bone tissue engineering for manyclinical aspects of orthopedic, cranio-maxillofacial and dental applications.

HealthcareTECHNOLOGY DESCRIPTION



Healthcare > CELL/TISSUE THERAPY

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Cell/Tissue Therapy

CTT-0895 3D vascularized pancreatic islets - for islets transplantationThe present invention provides an advanced tissue-engineering technique for thedevelopment of 3D co-culture systems that reconstruct vascularization of pancreatic tissue exvivo. In this novel engineered 3D pancreatic model, isolated pancreatic islets can be co-cultured with endothelial cells. The endothelial cells organize into 3D tubes throughout theengineered construct and form vascular network-like structures resembling in vivovasculature. This presence of endothelial cells forming 3D vessel-like structures was found tobe critical for islet survival. This model can provide an important tool for the therapeutictransplantation of islets, greatly increasing the success of the procedure.

CTT-1003 Methods for promoting cell transfection in vivo (ultrasound)Presently, no vector has been approved by the FDA for in vivo gene delivery due to sideeffects and the death of patients in clinical trials of viral vectors. Technion researchers havedeveloped a method for using non-viral vectors – therapeutic ultrasound waves for thedelivery of genes with or without the help of additives. The uses of the invention are genedelivery for laboratory use as well as gene delivery for clinical applications to most tissues andorgans. Currently a gene gun is used in some applications but only for superficial skin deliverywith very low and transient transfection. The invention describes using therapeuticultrasound waves, approved for drug delivery to the skin, for the delivery of naked DNA tomost tissues and internal organs.

CTT-1023 Layered hydrospinning for the production of tissue engineering scaffoldScaffolds seeded with cells are needed for tissue engineering. The present invention utilizeselectrospinning with a twist. Instead of spinning on a solid electrode, we spin on the surfaceof a liquid reservoir. The resulting nanofibrous membrane formed on the surface of the liquidis then assembled on a glass slide, and cells are seeded between each layer. Many suchassemblies create a layered scaffold. The final scaffold is put in a vacuum environment, whereit swells massively in size. This invention provides a novel scaffold with a few cubiccentimeters in volume that is filled with cells and is capable of tasks such as filling a criticalgap in bone healing.

CTT-1164 Therapeutic use of modified Endothelial and Endothelial Progenitor Cells (EPCs)This invention suggests transplanting the gene for the proteins nephrin and podocin, whichforms a filtering layer called slit diaphragm, to the Endothelial Progenitor Cells (EPCs). Weexpect the engineered cells to become a part of the kidneys endothelial layer, forming a newbarrier and preventing excessive exit of proteins through the urine. In addition, the specialfeature of the new layer may be used as a microcapsule.


Healthcare > CELL/TISSUE THERAPYDIAGNOSTICS

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Cell/Tissue Therapy

CTT-1311 Composite biomaterials for cardiac tissue engineeringCoronary heart disease (CHD) is a significant burden to healthcare systems as it is one of theleading causes of death in developed countries. In the present invention we propose aninnovative strategy for treatment using a variety of injectable degradable compositebiomaterials. This composite biomaterial promotes cell growth and may be used as cardiacpatch for the regeneration of myocardial infarction and regeneration of other tissues/organs.

CTT-1036 Ultrasound-mediated drug deliverySee ‘Drug Delivery‘, page 20

STM-0652 Methods of preparing feeder cells-free, xeno-free humanembryonic stem cells and stem cell culturesSee ‘Stem Cells‘, page 34

Diagnostics

DIA-0845 Concomitant analysis of salivary tumor markers –A new diagnostic tool for oral cancerThe present invention relates to a method and diagnostic kit for diagnosing oral or oral-pharyngeal cancer using salivary testing. The novel method examines salivary tumor markers. Aconcurrent analysis of these markers showed sensitivity, specificity, and negative and positivepredictive values in the range of 72-75%. Salivary testing is a non-invasive, effective andattractive alternative to serum testing.

DIA-0887 Method and kits for diagnosis of schizophreniaMethods and kits for the diagnosis of schizophrenia, employing mitochondrial complex I as aperipheral biological marker, have been developed. Minimizing the impact of the diseasedepends mainly on early diagnosis and appropriate pharmacological and psycho-socialtreatment. At the present, diagnosis is based on the self-reported experiences of the patient,in combination with secondary signs observed by a psychiatrist or clinical psychologist; hencemisdiagnosis is not a rare event. The identification of this biological marker provides a moreprecise diagnosis and prognosis.



Healthcare > DIAGNOSTICS

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Diagnostics

DIA-1061 Detection of ABCG2 activity using OH-bearing ImidazoacridinonesMultidrug resistance efflux pumps are a major obstacle to cancer patients' recovery usingchemotherapy. Despite the major advance in chemotherapy protocols and the novel potentanti-cancer drugs, chemotherapy of many cancer patients remains statistical and the patientis treated solely based on the pathological diagnosis of his cancer. Application of anticancerdrug that is extruded by the MDR pump does not improve the patient's status, exposes himto the harsh chemotherapy side-effects and leads to a tumor which is highly refractory tochemotherapy. In this invention Technion leading researchers have developed a method foridentification and quantification of MDR pumps within cancer cells within one hour.

DIA-1092 A system for assessing chemosensitivity of lymphoblastic leukemia patientsto high dose MTX-containing combination chemotherapyAn efficient treatment of leukemia patients depends on many factors. One of them is thepatients' responsiveness to the anticancer drug MTX. Technion researchers havediscovered that impaired splicing of the FolyPolyGlutamate Synthetase (FPGS) enzymemay result in resistance to MTX and consequently to treatment failure. Our technologyenables to predict the patient's chemotherapy treatment responsiveness.

DIA-1109 Improved diagnosis and immunotherapy of diseases based on analysisof the repertoire of serum soluble MHC-peptide antigensThe ssHLA- serum-soluble HLA molecules are found in high levels in the serum of humansafflicted with viral infections, autoimmune diseases, different types of cancers and in acuterejection after allotransplantation. This new discovery serves as an excellent prognostic toolfor early detection of cancer as well as therapeutic targets and vaccine.

DIA-1121 Hand-held probe for in vivo tooth ESR dosimetryNowadays when the risk of exposure to doses of ionizing radiation arises, there is an ongoingneed for a simple, inexpensive and accurate detecting device for radiation exposure dosage.The new technique based on Electron Spin Resonance (ESR) measures the absorbed radiationin human tooth enamel. It is perhaps the only such method which can differentiate amongdosage sufficiently for classifying individuals that has been exposed.

WAT-0526 Bacterial DNA fingerprint detectionSee ‘Water‘, page 14

WAT-0848 ROAKs for the capture and concentration of bacteriaSee ‘Water‘, page 15


Healthcare > DRUG DELIVERY

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Drug Delivery

CTT-1036 Ultrasound-mediated drug deliveryPresently, no vector has been approved by the FDA for in vivo gene delivery due to sideeffects and the death of patients in clinical trials of viral vectors. Technion researchers havedeveloped a method for using non-viral vectors – therapeutic ultrasound waves for thedelivery of genes with or without the help of additives. The uses of the invention are genedelivery for laboratory use as well as gene delivery for clinical applications to most tissues andorgans. Currently a gene gun is used in some applications but only for superficial skin deliverywith very low and transient transfection. The invention describes using therapeuticultrasound waves, approved for drug delivery to the skin, for the delivery of naked DNA tomost tissues and internal organs.

DDL-1022 Nanoencapsulation of chemotherapeutic and other drugs in beta-casein micellesIdeally, all drugs could be taken orally at home, optimizing patient response to treatment,treatment costs and patient quality of life. However, the hydrophobic nature of some drugs,especially chemotherapeutic ones, has prevented us from reaching this ideal situation. In thisinvention beta-casein (and other casein molecules) micelles are used to encapsulatehydrophobic chemotherapeutic drugs, enabling their oral uptake. These preparations may, ofcourse, be further coated with materials that make them gastro-intestinal tract site specific,as in targeted chemotherapy.

DDL-1026 Self-assembling capsidsThis invention describes a general synthetic strategy for producing chemical capsids at sizescales between fullerenes and spherical viruses. Mimicking the natural process by which thespherical envelope of virus particles is self assembled, the synthetic capsids are assembledfrom pentagonal organic molecules that have a built-in binding device on each of their fiveedges. Such structures can serve numerous functional roles, including chemicalmicroencapsulation and delivery of drugs and biomolecules, epitope presentation toallow for a new platform for immunization, observation of encapsulated reactiveintermediates, synthesis of nanoparticles of uniform size, and as structural elements forsupramolecular constructs.

DDL-1074 Compositions and methods for drug deliveryThe present invention is of a hydrogel containing an immobilized, naturally-occurring proteindrug carrier which may be used for sustained or controlled drug delivery applications. Thishydrogel matrix can also be made to be biodegradable. Following this concept, aphotopolymerizable hybrid hydrogel was developed, made of poly-ethylene-glycolconjugated to PEGylated albumin for affinity based drug delivery and tissue engineeringapplications.



Healthcare > DRUG DELIVERY

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Drug Delivery

DDL-1160 OAK cochleates: Method and composition for a delivery platformCochleate structures are essential in drug delivery field and may be used as adjuvants. Thecurrent invention suggests the formation of Cochleates from oligy acyl-lysine (OAK)compound. The modified OAK may have favorable properties with regard to cost ofproduction, lack of toxicity, stability and size.

DDL-1161 Cell-derived liposomes for drug-deliveryA major challenge facing cancer therapy is achieving specific cytotoxic effect towards cancercells while sparing the healthy ones. This invention describes the development of aninnovative targeted system for cancer therapy based on Mesanchymal Stem Cell (MSC)derived liposomes. The engineered liposome may contain variety of anti-cancer or cytotoxincompounds which will be released directly into the cancer cells.

DDL-1279 Cell-cell fusion method with application in specific deliveryof anti-nematode agents using proteins from the FF familyA new fusion method developed by Technion researchers depends on the expression of acertain glycoprotein of nematode origin in the membranes of both fusion partners. The newmethod for biological, protein mediated, cell to cell and virus to cell fusion can be used fortargeting anthelmintics in a nematode specific manner. The homotypic character of thefusion may have many applications in the medical and research fields.

DDL-1293 Thermally-induced protein-polyphenol co–assemblies: beta lactoglobulin basednanocomplexes as protective nanovehicles for EGCGEGCG is a water-soluble polyphenol (potent antioxidant) present in green tea with numerousattributed health benefits. However, this compound is highly susceptible to oxidation, limitingdrinks enrichment with EGCG. The present invention demonstrates the use of thermallymodified -lactoglobulin, forming clear solution containing nano-complexes smaller than50nm. The nano-complexes provide good protection against polyphenol deterioration andunwanted taste.

NUT-1051 Nano-complexes of beta-lactoglobulin and polysaccharides as vehiclesfor hydrophobic bioactive moleculesSee ‘Food and Nutrition‘, page 40


Healthcare > DRUG DISCOVERY

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DRS-0601 Methods, pharmaceutical compositions, oral compositions, filters andtobacco products for preventing or reducing tobacco smoke-associatedinjury in the aerodigestive tract of a subjectThe present invention relates to methods for preventing or reducing pathogenesis of oxidantstress-associated diseases of the aerodigestive tract. The invention describes methods foremploying hydroxocobalamin (vitamin B12a, OH-CO), deferoxamine (DES) and possiblyreduced glutathione (GSH) to reduce or prevent tobacco smoke-induced cellular ormacromolecular damage in the aerodigestive tract. The above chemicals may be applied incigarettes tobacco filters as well as in other forms, such as toothpaste, powder, liquiddentifrice, mouthwash, denture cleanser, chewing gum, lozenge, paste, gel, aerosol sprayor candies.

DRS-0911 Tobacco and tobacco packaging material for preventing or reducingtobacco-associated injury in the aerodigestive tractHo-Co was shown to reduce the level of HCN in cigarette smoke (CS) and to protect the oralcavity and airway peroxidases while DES neutralizes the redox active iron in CS and saliva.These two chemicals provide ample protection from CS and tobacco products associated withoxidative damage and inflammatory and carcinogenesis processes. Adding them to tobaccoor tobacco products will decrease tobacco related health problems.

DRS-0933 Prevention or reduction of injury induced by tobacco related materials as smokein the aerodigestive tract with the copper chelator D-penicillamineOral and oropharyngeal cancer, which is usually squamous cell carcinoma (OSCC), is the sixthmost common cancer worldwide. It is primarily induced by exposure to tobacco. The presentinvention describes how, when chelating copper prior to exposure of cells to cigarette smoke(CS) in the presence of saliva, we were able to prevent the induced damage. By adding acopper chelator to lung cancer cells (H1299 cell line), which were exposed to CS in thepresence of saliva, we prevented the cell death induced by the synergetic effect of CSand saliva.

DRS-0938 Prevention or reduction of biological injury induced by tobacco related materialsas smoke and/or free radicals and/or other inducers of oxidative stress throughthe MPTP/TSPO pathwayMPTP and/or TSPO have been previously correlated with various pathologies. However, theyhave never been correlated with the biological injury induced by tobacco products such ascigarette smoke (CS), nor has it been suggested that MPTP/TSPO related drugs/ligands beused to avoid such pathologies. Initial results of both in vivo and in vitro experiments showedthat CS induced a significant alteration in the specific binding capacity of TSPO, which maybe related to the pathogenic pathways leading to various CS induced pathologies such ascancer, aerodigestive and lung diseases such as COPD, cardiovascular diseases, oralperiodontitis and many others.




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DRS-1087 Novel discovery presenting potent protector againstthe lethal effect of cigarette smokeCigarette smoke (CS) is the major risk factor for epithelial cancer in the aero-digestive tractand especially for lung and oral cancers. Technion researchers evaluated the protective effectof D-Penicillamine (PenA) against the lethal effect of cigarette smoke (CS) both in theabsence of saliva and in its presence (a most pro-oxidative condition). This noveldemonstration is of paramount importance and can be used to attenuate the risks associatedwith smoking.

Drug Discovery: Anti - Arrythmatic

DRS-0546 Tricyclic compounds and their uses as antiarrhythmicantifibrillatory and defibrillatory agentsThe invention here centers on the production of novel compounds with antiarrhythmic, anti-fibrillating activity. Ventricular arrhythmia, such as ventricular tachycardia and ventricularfibrillation (VF), plays a major role in sudden cardiac death. The novel compounds underdiscussion were shown to be effective ventricular defibrillating drug candidates. They exhibitsignificant in vivo defibrillatory activity. These compounds also exhibit antifibrillatory activityby elevating the fibrillation threshold potential. All of these behaviors suggest that such drugscould be used to treat VF either by themselves or together with electrical defibrillators.

Drug Discovery: Anti - Inflammatory

DRS-1192 Novel class of antibiotics based on naturally lethal peptide sequenceThe increasing appearance of antibiotic resistant bacteria has raised the need for discovery ofnew antibiotics. We discovered naturally lethal peptide sequence which can cause inhibitionof protein synthesis and arrest of the ribosome function, ending with cell death. Thissequence can be used as a compound in novel antibiotics highly specific and very efficient.


DRS-0673 Bifunctional antibiotics for targeting rRNA and resistance-causing enzymesNeomycin B is an important antibiotic, commonly used as a food-additive for agriculturalpurposes. As a result of antibiotic formulations having been used for several decades,resistance to antibiotics has been evolving. The present invention is a Neomycin B that hasbeen modified by the addition of one extra sugar ring. This modification has been shown toboth enhance its antibacterial activity against pathogenic bacterial strains and to produce asignificant decline in bacterial resistance. The compounds are also active against Bacillusanthracis (anthrax) and are able to inhibit the proteolytic activity of its lethal factor.



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DRS-0932 Novel antimicrobial agentsOver the past decades, advancement in the field of antimicrobial agents had reduceddramatically illness and death due to infectious diseases. However, almost all the prominentinfection causing bacterial strains have developed resistance to antibiotics. The presentinvention relates to novel antimicrobial agents (polymers) designed for exertion ofantimicrobial activity while being stable, non-toxic and avoiding development ofresistant strains.

DRS-1006 OAKs: Novel library of antibiotics that mimic host defense peptidesIn this invention a novel library of peptides that mimics host-defense peptides was created.The peptides form a new family of antibiotics with new mechanisms of action that renderresistant bacteria susceptible again.

DRS-1049 Design, synthesis and evaluation of novel Fluoroquinolone-Aminoglycosidehybrid antibioticsBacterial resistance to antibiotics plays a major role in today's medical world. A series of newhybrid antibiotics containing fluoroquinolone and aminoglycoside antibiotics were designed,synthesized and their antibacterial activities were determined. This combination yielded anew superior antibiotic: very potent on the one hand and resistant to bacterial resistanceenzymes on the other.

DRS-0607 Methods for the preparation of selectively-substituted corroles andnew substituted corrolesSee ‘Drug Discovery: Neoplastic Disorders‘, page 25

Drug Discovery: Diabetes

DRS-1000 Overcoming insulin resistance state via alleviating GLUT4 repressioncaused by AHNAKAHNAK is a giant phospho-protein that plays a role in glucose homeostasis by modulatingGLUT4 gene repression by arachidonic acid. Its levels were shown to be increased in adiposeand muscle tissues in insulin resistance states like obesity. According to the above, AHNAK isan excellent molecular therapy target for molecular therapy in insulin resistance states likeobesity and type II diabetes.

DRS-1275 T-cell Receptor-Like (TCRL) antibodies directed to beta-Islets antigenspresented by MHC class IIType 1 diabetes (T1D) occurs when the autoimmune reaction against the pancreatic beta-isletcells prevents production of the hormone insulin. Technion researchers have developedspecific antibodies that can bind the MHC II-peptide complexes in a peptide-specific HLA-restricted manner. The antibody binding prevents the binding of T-cells and the followingautoimmune reaction which may lead to the development of Type 1 diabetes.




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Drug Discovery: Hypolipidemic agents

DRS-0934 Metallocorroles: A novel compound fightingAtherosclerosis and high blood Cholesterol levelsCardiovascular disease and stroke resulting from atherosclerosis might be decreased by usingnew substances such as metallocorroles, which effectively reduce cholesterol levels and LDLoxidation, thereby slowing and possibly preventing the formation of atheromatous plaques.

Drug Discovery: Immunomodulators

DRS-0606 Methods and pharmaceutical compositions for immune deception,particularly useful in the treatment of cancerIn the field of Oncology, tumor cells have developed sophisticated strategies to escapeimmune effector mechanisms. One of the well known escape mechanisms is using thedownregulation of MHC class I molecules, which are the antigens recognized by the immunesystem cells. This invention presents a new recombinant molecule that binds to cancer cells,making them detectable by immune system cells. This new discovery may open the way forthe development of new immunotherapeutic strategies.

DRS-0655 An antibody fragment capable of modulating multidrug resistanceThe present invention relates to an antibody fragment capable of binding to P-glycoproteinassociated with multidrug resistant (MDR) cells. The present invention also relates tocompositions and methods utilizing such an antibody fragment for inhibiting drug effluxactivity in MDR cancer cells. Cancer chemotherapy often fails due to the development ofacquired or intrinsic resistance in cancerous cells. A key mechanism of MDR is theoverexpression of an energy-dependant efflux pump, known as the multidrug transporter.The present invention demonstrates an antibody that selectively reacts with Pgp-overexpressing cells and is, therefore, an effective inhibitor of drug-efflux activity inmulti-drug resistant cells.

Drug Discovery: Neoplastic Disorders

DRS-0607 Methods for the preparation of selectively-substituted corrolesand new substituted corrolesTechnion researchers have developed a method for synthesizing selectively-substitutedcorroles and new substituted corroles. The invention demonstrates that highly selectivefunctionalization of beta-pyrrole-unsubstituted corroles can be used for the easy preparationof novel amphiphilic derivatives and of complexes with metal-centered chirality. These novelcompounds may be used for tumor detection and treatment, in photovoltaic devices, ascatalysts and as intermediates.



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Drug Discovery: Neoplastic Disorders

DRS-0896 OAKs: Novel cancer-fighting mimics of host-defense peptidesIn this invention a novel library of peptides that mimics host-defense peptides was created.The peptides in this library were found to have anti-cancerous activity.

DRS-0972 A systems approach for understanding and controllingthe reactivity of immune cell populations against cancerTumor infiltrating lymphocytes (TILs) form immune populations with potential reactivityagainst melanoma. The degree of reactivity varies considerably among different TILpopulations but the underlying network that governs the reactivity is poorly understood. Theinventors were able to extract a simple set of subpopulation composition-based rules thatexplain reactivity to a large extent. Guided by the rules, they were able to restore anti-melanoma reactivity of nonreactive TILs by rational depletion and enrichment of selectedsubpopulations. This invention describes a generic approach for the prediction,understanding and control of a cell mixture function.

DRS-1256 Novel antibodies which are able to bind soluble T-Cell receptor ligandsType 1 diabetes occurs when the autoimmune destruction of pancreatic beta-islet cellsprevents production of the hormone insulin. The present invention utilizes TCR-Likeantibodies that can bind MHC II/peptide complexes in a peptide-specific HLA-restrictedmanner. These TCR-like Fabs represent a valuable tool for studying antigen presentationduring autoimmune inflammation, and may constitute novel therapeutic agents for treatinghuman diseases involving excessive immune reactivity.

DRS-1315 Anticancer therapeutics via imidazoacridinone-and sunitinib-dependent lysosomal photodestructionMultidrug resistance (MDR) poses major obstacle for cancer treatment. Thus, developingnovel strategies to overcome MDR is of a paramount clinical significance. The presentinvention proposes anticancer therapeutics and describes a new strategy to overcome MDR,based upon lysosomal sequestration of cytotoxic agents of the imidazoacridinones (IAs)family and consequent lysosomal photodestruction by illumination.


DRS-0855 Heterocyclic derivatives, pharmaceutical compositions and methods of use thereofIn this invention a new compound, a ligand to the peripheral-type benzodiazepine receptor(PBR), is introduced. The PBR-ligand attachment induces anti-apoptotic activity, which is ofextreme value in neurodegenerative diseases and traumatic brain damage. Traumatic braininjury is the leading cause of disability in individuals below the age of 40.




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DRS-1019 Multifunctional catalytic antioxidants as cyto-protective and cyto-rescuingagents for chronic, systemic, and neurodegenerative diseasesTreatment of neurodegenerative disorders, such as Huntington’s disease and amyotrophiclateral sclerosis (ALS), as well as disorders such as diabetes, has been frustrated by theshortcomings of the available symptomatic drugs. These drugs are incapable of slowingdown the progression of the disease and neuronal degeneration. Ongoing research hasclearly indicated that therapies aimed at blocking oxidative processes involving reactiveoxygen species (ROS) and nitric oxide (NO) production may delay the progression of thedisease. Metallocorroles designed in the invention have demonstrated remarkable antioxidantproperties and have been proposed as an ingested medicine for the above stated conditionsin addition to the previous work on atherosclerosis.

Drug Discovery: Orphan Drugs

DRS-0816 Redesign of aminoglycosides for treatment of human geneticdiseases caused by premature stop mutationsCystic fibrosis, Duchenne muscular dystrophy and Hurler syndrome are some of the diseasescaused by nonsense mutations: false stop signals in the DNA sequence that bring about thepremature termination of the synthesis of specific proteins. Some aminoglycoside antibioticshave been found effective in overcoming this problem, but they cannot be used clinicallydue to high levels of toxicity. Technion researchers have successfully synthesized minimallytoxic aminoglycosides, with an improved functional activity, which can be used formedicinal treatment.

Drug Discovery: Phosphate regulators

DRS-0710 Compositions and methods for treating disordersassociated with abnormal phosphate metabolismThe present invention relates to methods for treating disorders associated with abnormalphosphate metabolism. Hyperphosphatemia has been associated with elevated mortality andmorbidity among patients with chronic renal failure. The invention suggests assessinginducers of GalNAc-T3 as a new strategy for the treatment of hyperphosphatemia-relateddisorders such as renal failure, as well as assessing inhibitors of GalNAc-T3 for the treatmentof disorders associated with hypophosphatemia, such as hypophosphatemic rickets.


Healthcare > DRUG DISCOVERYMEDICAL DEVICE

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Drug Discovery: Renal disorders

DRS-0764 Methods for treatment of Renal FailureRasagiline is an approved anti-Parkinson drug in Europe and Israel. The present inventiondescribes in vivo experiments demonstrating the improvement in function of hypoperfused aswell as normal kidneys pretreated with Rasagiline and its derivatives. Rasagiline derivativesproduce significant diuretic and natriuretic responses in association with increased GFR in ratswith CHF as well as induce diuretic and natriuretic responses accompanied by improved GFRin the ischemic kidney. It is proposed that this derivative can be used for the treatment ofacute and chronic kidney failure.

Medical Device

MAE-0680 Ion concentration sensorIon concentration measurements, particularly pH measurements, are performed routinely inthe chemical, biochemical, biomedical and other fields. Also, much effort has been investedin creating a combined ion and image sensors for advanced biotelemetry systems.Conventional ion concentration sensors require readout circuitry to convert an electricalresponse to values corresponding to the ion concentration in the solution. This circuitryincreases the size and complexity of the sensor and increases its power consumption.Furthermore, it also adds limitation to the bandwidth and reduces the stability of the sensor.This sensor can perform simultaneous ion and image sensing without readout circuitrycreating a critical device for advanced biotelemetry systems that are energy-efficient, compactand reliable.

MED-0706 Electronic receptor and its application to controlling biological processesThe present invention aims at gaining electrical control over biological processes, namely,triggering or suppressing a selected biological pathway by an electronic signal presented tothe system. The strategy relies on the selection of antibodies that recognize and bind aspecific set of nano-scale electrodes biased to a certain voltage configuration. Theimplications of such an interface are far reaching. One may envision sensors that probeseveral biological parameters, converting them into electronic signals.

MED-0835 Fast retinal imaging by parallel projectionsThe present invention relates to a device and method for fast retinal imaging and extractionof medical parameters from these retinal images. The innovative technology provides animaging system that takes a single shot of the retina at various depths, obtaining retinaldepth information immediately and providing fast information and continuity of data. Theexpected price of the system should be less than optical coherence tomography systems, andonly slightly more than fundus cameras.



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Medical Device

MED-0867 Vectorial vortex mode transformation for a hollow waveguideusing subwavelength structuresHollow waveguides present an alternative to solid core fibers in the IR regime where suitableoptical materials are scarce. Due to their air core, they can also be used for broad-spectrumhigh power transmission due to small insertion losses. This makes them suitable for use inindustrial or medical applications or for spectroscopic and radiometric measurements.Conventional hollow waveguides rely on multimode operation; however, this technologyallows for the excitation of only a single waveguide mode making it well-suited for certaindevices like hollow waveguide lasers.

MED-0939 Cylindrical probe for ex-situ nuclear magnetic resonance spectroscopyThis invention is a new type of ex situ nuclear magnetic resonance (NMR) probe withspectroscopic capability. NMR, and its descendant, magnetic resonance imaging (MRI) areamong the most powerful and versatile analytic and diagnostic methods in science. Currentdevices suffer from the need to employ large magnets that surround the examinedsample/object. The large magnet and the correspondingly large RF coils are a major factor inthe complexity and the high cost of NMR and MRI systems. In addition, in many cases thesample cannot be placed inside the bore of the magnet or cannot be moved. The presentinvention describes a new type of ex situ NMR probe, which through innovative design,achieves mobile NMR/MRI capability. The achievable spectral resolution is on the order of~0.5-1 ppm.

MED-0991 In vivo flow-cytometryIn this invention, a method for imaging the cross section of a vessel for detecting the flow ofcells using spectrally encoded imaging was developed. This method provides visualinformation on the scattering particles, including their size, shape, brightness, as well as theirlocation within the vessel. Such information could significantly increase the accuracy of flowcytometry and provide additional capabilities, such as cell sorting and the modification anddestruction of specific cells. Potential applications include in vivo and ex vivo flow cytometryfor industrial and clinical applications. For in vivo applications, the compact dimensions andsimplicity of the probe, which is approximately 20 x 5 x 5 mm in size with no moving parts,could enable endoscopic flow cytometry in various locations in the body.

MED-1138 System and method for near surface surgery simulationThis novel invention describes a system and method for simulation of near surface surgeries,allowing full visual, audio and haptic imaging. This invention uses a unique prism basedmass-spring physical simulation to illustrate necessary operations for near surface (skin)surgeries such as real-time incisions and undermining with force feedback. This tool will allowsurgeons to practice surgical procedures near surface without using animals or cadavers.



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Medical Device

MED-1152 Techniques for spectrally encoded endoscopyWe propose a few innovative techniques for spectrally encoded endoscopy. One technique isa method for multiple-channel spectrally encoded endoscopy (MC-SEE), in which theillumination and the collection of optical paths are separated in space. This invention enablesa larger depth of field imaging, speckle noise reducing and signals detection of differentexcitation and emission wavelengths. The other technique, using dispersion, may be effectivein optimizing imaging quality and field of view.

MED-1193 Microdevice for measuring water content in vivo and in vitroWater content in tissue, is strongly associated with ageing and degeneration. Early detectionof variations in water content in tissue may be of immense diagnostic benefit and is of crucialimportance in preventing future pathological processes. Furthermore, knowledge of watercontent is also important in applications of tissue engineering. Unfortunately, up to date,simple and direct techniques to evaluate water content in tissue are not available yet. Ourtechnology proposes a solution to the problem. The technology is minimally invasive, providesreal time results and reduces extra manufacturing costs.

MED-1227 Multifocal ultrasound and its effect on biological tissues,in particular via ultrasound effect on biological membranesUltrasound has been extensively used for imaging for 60 years, and is now being studiedtowards clinical therapeutic application. Understanding the basic mechanism of its function iscritical. Technion Researchers propose a hypothesis whereby ultrasound induces bubbleformation in the intra-membrane space in cells, between the two lipid leaflets. Those bubblesaccumulate, creating pockets of gas. As the pockets grow, surrounding structures are beingpushed. A possible therapeutic application of this discovery is in the field of neurophysiology,where the use of multifocal ultrasound on neural tissues is likely to become essential tofuture treatment for people who have a major deficiency in their sensory systems, such asblindness or deafness.

MED-1265 Method for the fabrication of hollow nanostracturesThe fabrication of high aspect ratio hollow devices at the submicrometer length scale is anunsolved challenge by conventional techniques. The present invention allows the fabricationof hollow structures of high aspect ratio with a very high throughput, as the entire substrateis processed in parallel. It allows defining structures of different shapes and sizes at a definedposition, thus enabling to mix different objects on the same substrate in predefined positions.

MED-1285 Manipulation of cells using combined opto-acoustic excitationThe present invention describes targeted and rapid means for reversible mechanicalmanipulation of individual cells (e.g. activation of excitable cells such as neurons) using thecombined, synergistic action of light and ultrasound. This method provides modulation of theindividual cell from distance in a selective, reversible, and rapid way and may be used invarious applications as neuron stimulation for inner ear prosthesis, retinal prosthesis,implanted pacemaker and more.




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Medical Device

MED-1289 A non-invasive method for monitoring thermal tissue treatmentThermal treatments such as HIFU, RF and lasers for minimal invasive therapy and other clinicalor cosmetic application have gradually become more and more prevalent. We suggest theuse of CT which can be utilized for minimally or non-invasive image guided surgery instead ofthe expensive MRI. The suggested method may potentially monitor tissue temperature andamount of damage induced during thermal treatment in a non-invasive manner.

MED-1299 Differential, calibration-free and reference-electrode-freeCMOS ISFET for ions and pH measurementsThe present invention relates to a novel device for acidity (pH) or ion concentrationmeasurements. The proposed device is differential, calibration-free and reference-electrodefree CMOS ISFET with remote sensing antennas. It eliminates the need for costly calibration,provides better stability over time and can be used where minuscule sensors are required, asin in vivo medical and biomedical applications.

MED-1303 Damaging cells using nanoparticles and short laser pulsesCurrently used anti-cancer treatments are highly toxic to both healthy and cancerous tissues,often leading to patient's death due to the treatment itself. We suggest novel strategy forthe treatment of cancer by targeting cancer cells with carriers conjugated to goldnanospheres and illuminating the cells by short visible laser pulses. It will ensure local tissuedamage whilst avoiding massive temperature elevation which may damage healthy tissues.

MED-1327 Method for optical stimulation and monitoring of neuronsThe present invention outlines a method for creating a novel neural interface based onoptically controlling neurons in a cell-containing hydrogel based transparent transplant. Thetransplantable neural network could be applicable in various fields. One of the fields is CNStissue engineering, providing a possible treatment for brain injuries, stroke,neurodegenerative diseases and more.

MED-0949 Detection and diagnosis of chronic renal failure andkidney related diseases by Electronic NoseEnd-Stage renal disease (ESRD) is a debilitating medical condition of chronic kidney failure,which requires intensive and costly treatment through dialysis or transplantation. Earlyscreening and intervention may reduce neuropathy progression and may bring to remissionincreasing. Our suggested technology may be able to differentiate between “healthy” and“renal failure” breath, which may contribute to the early detection of the disease.


Healthcare > MEDICAL DEVICERESEARCH EQUIPMENT

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Medical Device

MED-0971 Non-contact holographic stimulation technology fornext-generation vision restoration devicesA unique technology for direct optical stimulation of neurons has been developed in theTechnion. This Technology could have diverse applications in the field of advancedneurological devices and particularly the development of next-generation vision restorationdevices. The new, non-contact method is based on rapid holographic stimulation and enablesenergy- efficient patterned activation of many neurons with high resolution (single cells) andhigh light efficiency.

CHM-0794 Ceramic coating on dental implant abutmentsSee ‘Chemistry and Materials Science‘, page 41

CHM-1097 Microstructure control of ceramic matrix nanocompositesSee ‘Nanotechnology‘, page 49

COM-1158 Cancer diagnostic probeSee ‘Optics and Lasers‘, page 55

DIA-1121 Hand-held probe for in vivo tooth ESR dosimetrySee ‘Diagnostics‘, page 19

Research Equipment

RES-0837 Floating electrode dielectrophoresis (feDEP)The present invention relates to the use of electrically floating electrodes (fe) for thedielectrophoretic (DEP) manipulation of bioparticles. feDEP is an enabling technology thatoffers a significant leap towards cheap, disposable, and therefore, commercially available DEPdevices. The use of floating electrodes will considerably facilitate device fabrication andoperation, as well as reduce device dimensions and offer interconnect-free devices. Also,since floating electrodes do not require an external connection, their geometries are muchmore flexible. This opens a doorway for using feDEP in cellular patterning and tissueengineering.

RES-0870 Electrical control over Antibody-Antigen bindingTechnion inventors have discovered a method to electrically control the binding of anantibody to its antigen. The formation of such bond is highly influenced by surroundingvoltage, because the electrical charges of the amino acid's residues in the antibody proteinare affected by it. The method facilitates exquisite control over one of the main interactionsresponsible for biomolecular recognition, which is a prominent function of theimmune system.



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Research Equipment

DDL-1074 Compositions and methods for drug deliverySee ‘Drug Delivery‘, page 20

MAE-1038 Acoustic particle focusingSee ‘Measurement Methods and Systems‘, page 46

MED-1152 Techniques for spectrally encoded endoscopySee ‘Medical Device‘, page 30

STM-0652 Methods of preparing feeder cells-free, xeno-free human embryonicstem cells and stem cell culturesSee ‘Stem Cells‘, page 34

Stem Cells

STM-0611 Methods of generating human cardiac cells and tissues and uses thereofThis new technology consists of a method for generating cells having characteristicsassociated with a cardiac phenotype. The phenotypic properties of cardiomyocytes derivedfrom human ES (embryonic stem) cells are characterized by cardiac-specific antibodies,confirmed by electron microscopy and RT-PCR of several cardiac-specific genes andtranscription factors. Positive and negative chronotropic effects were induced by applicationof isoproterenol and carbamylcholine, respectively. The generated humanES cell-derived cardiomyocytes displayed structural and functional properties of early-stagecardiomyocytes. Establishment of this unique differentiation system may have significantimpact on the study of early human cardiac differentiation, functional genomics,pharmacological testing, cell therapy, and tissue engineering.

STM-0613 Differentiated human embryoid cells and a method for producing themThe present invention is a process for obtaining human derived embryoid bodies (hEB). It isbased on the finding that human embryoid bodies may be obtained in vitro from humanembryonic stem cells suspended in a liquid medium. These hEBs contain mesoderm,ectoderm and endoderm cell lineages and may be used as a source of cells of the differentlineages. The hEBs can then be used as a source of cells for use in transplantation orinoculation into a human recipient, in order to treat various diseases or disorders, to assist intissue repair, and to substitute for degenerated tissue.


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Stem Cells

STM-0629 Endothelial cells derived from human embryonic stem cellsThis innovative technology enables the production of a population of embryonic endothelialcells in vitro from human embryonic stem (ES) cells. The process mimics the differentiation stepsof human ES cells into endothelial cells, forming vascular-like structures. Human embryonic-derived endothelial cell behavior was characterized in vitro and in vivo. In vivo, whentransplanted into SCID mice, the cells appear to form microvessels containing mouse blood cells.These cells could be beneficial for applications such as engineering new blood vessels,endothelial cell transplantation into the heart for myocardial regeneration, and induction ofangiogenesis for treatment of regional ischemia.

STM-0630 Novel methods for the in vitro identification, isolation anddifferentiation of vasculogenic progenitor cellsThe present invention is of a simplified and inexpensive method for the in vitro identification,isolation and culture of human vasculogenic progenitor cells. The technology allows for theisolation and enrichment of a common precursor for endothelia, smooth muscle andhematopoietic cells derived from human embryonic stem cells. This precursor has been foundto express early endothelial and hematopoietic markers and under specific conditions, itpersists in endothelial differentiation, forms vessel-like structures with blood cells, anddifferentiates into smooth muscle cells (SMC). The method and the progenitor cells describedmay be used for in vitro vascular engineering, among other things.

STM-0646 Method of dynamically culturing embryonic stem cellsThe present invention is a method for dynamically generating human embryoid bodies thatcan be used for generating lineage-specific cells and cell lines. All potential applicationsdepend on the availability of a controlled scaleable bioprocess of the differentiated cells. Thepresent invention describes the formation of human embryoid bodies (hEBs) in dynamicsystems, and discloses simple, culture-specific conditions that allow the formation of hEBs.The initial event participants in the developing hEBs did not change when moved from theirconventional culture to dynamic systems, indicating the possibility of simple scaleable cellproduction in a well-defined dynamic environment for clinical and industrial applications.

STM-0652 Methods of preparing feeder cells-free, xeno-free humanembryonic stem cells and stem cell culturesHuman Embryonic Stem (hES) cells have already made a great contribution in research onearly human development, and they are very likely to be used in the future for cell-basedtherapies. Traditionally, these cells have been cultured on mouse embryonic fibroblast (MEF)feeder layers, which allow their continuous growth in an undifferentiated state. However, theuse of hES cells in human therapy requires an animal-free culture system where the exposureto mouse retroviruses is prevented. The present invention provides a novel feeder layer-freeculture system for hES cells, based on medium supplemented with 20% serum replacement,combination of growth factors and fibronectin matrix.




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Stem Cells

STM-0695 Engineering three-dimensional tissue structures usingdifferentiating embryonic stem cellsHuman embryonic stem (hES) cells hold promise as an unlimited source of cells fortransplantation therapies. The present invention is a method for the control of hES cellproliferation and differentiation into complex, viable 3D tissue constructs. The inventiondescribes the use of biodegradable polymer scaffolds for promoting hES cell growth anddifferentiation, and for the formation of 3D structures. This approach provides a uniqueculture system for addressing questions in cell and developmental biology, and provides apotential mechanism for creating viable human tissue structures for therapeutic applications.

STM-0721 Growth and differentiation of human embryonic stem cellswithin three dimensional scaffoldsThe present invention relates to methods for generating embryoid bodies (EB) using three-dimensional scaffolds. The invention describes, for the first time, the generation of EBs onporous scaffolds and demonstrates that hEBs can be generated directly from hES suspensionswithin 3D porous alginate scaffolds. The scaffold-borne EBs were of a high quality, essentiallydevoid of necrotic centers, and exhibited a high proliferation rate and differentiation to allthree germ layers, while displaying minimal agglomeration. These new methods can be usedfor isolating multipotent lineage-specific cells and for the large-scale production of lineage-specific differentiated cells.

STM-0722 Stem cell lines derived from delayed blastocyst culture and their usesThe present invention relates to a method for generating stem cell lines from extendedblastocyst cultures (embryos beyond the blastocyst stage). The new technology demonstratesfor the first time that multipotent or pluripotent cell lines can be derived from embryos at alater stage than the blastocyst stage. The newly developed method is an opportunity to gaininsights into the features of the cells in the post-implantation human embryo – betweenimplantation and gastrulation – using in vitro models.

STM-0777 L6-IL6 receptor chimera supports the feeder layer-free culture of hESCsHuman embryonic stem cells (hESCs) have contributed significantly to the research on earlyhuman development and may have future application in cell-based therapies. These cellshave been cultured on mouse embryonic fibroblast (MEF), causing increased risk for exposureto mouse retrovirus. The present invention provides a new feeder layer-free culture system forundifferentiated hESCs for any industrial or clinical uses.



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Stem Cells

STM-0789 Multicellular systems of pluripotent human embryonicstem cells and cancer cells and uses thereofThe invention is a novel experimental platform for cancer research that uses human stem celltechnology. The process grows human tumor cells in a pre-clinical experimental setting in atissue micro-environment consisting of differentiated human cells. The multicellularcomposition is placed in an animal model. The model takes advantage of the potential ofhuman stem cells to differentiate in the experimental setting into any and all of the body’sdifferent cell types, and thus mimics a normal human tissue micro-environment.

STM-0800 Isolation, purification and characterization of human embryonic stem celland human fetal stem cell derived progenitors and their differentiationinto osteoblasts, chondrocytes and tendocytesThe present invention describes a method for the efficient derivation of connective tissueprogenitors (CTPs) from hES cells. These cells have multi-lineage developmental potential,yet are committed to connective tissue derivatives. Moreover, the potential of these cells togenerate tendon-like structures is also shown. By applying the long-term high-density culturetechnique to these cells, the researchers successfully assembled cylinder-shaped constructsthat contained typical ultrastructure characteristics and biomechanical properties ofearly tendons.

STM-0801 Development of a dynamic process for the formation,propagation and differentiation of human embryoid bodiesThis technology focuses on a platform for production of human embryoid bodies (EB) fromhuman embryonic stem cells. The production takes place in a controlled stirred tank reactor(STR) in a robust scalable process with high efficiency.

STM-0890 Adult stem cell-derived connective tissue progenitors for tissue engineeringThe present invention provides methods for generating and utilization of connective tissueprogenitor cells from adult stem cells, successfully overcoming shortcomings of presentlyknown configurations. Adult stem cells differentiate into connective tissue progenitor cellscapable of being maintained in a proliferative, non-terminally differentiated state for at least20 passages in culture, and capable of differentiating into cells of chondrogenic lineage,osteogenic lineage, adipocytic lineage, tendon lineage and ligament lineage. The connectivetissue progenitor cells are capable of forming extracellular matrix, mineralized matrix, bonetissue, cartilage tissue, tendon tissue and ligament tissue.

STM-0919 Ectodermal precursor cell line derived from human embryonic stem cellsThe present invention provides an isolated stable ectodermal IT1 cell line from human ESC,capable of differentiating into epidermal and corneal cells that could reconstitute in vitropluristratified epidermis and cornea. Applications of this invention include use for pre-clinicaltrials concerning skin and cornea pathologies, production of transplantable epidermis, repairof wounded corneas and design of cellular models for cosmeto-toxicology.




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Stem Cells

STM-0923 Identification and selection of cardiomyocytes duringhuman embryonic stem cell differentiationHuman embryonic stem (hES) cells are pluripotent cell lines that can differentiate in vitro intocell derivatives of all three germ layers, including cardiomyocytes. The present invention is thegeneration of transgenic hES cell lines and single-cell clones that express a reporter gene(eGFP) under the transcriptional control of a cardiac-specific promoter. The generation ofthese transgenic hES cell lines may be used to identify and study early-cardiac precursors fordevelopmental studies, to robustly quantify the extent of cardiomyocyte differentiation, tolabel the cells for in vivo grafting, and to allow for the derivation of purified cell populationsof cardiomyocytes for future myocardial cell therapy and tissue engineering strategies.

STM-0956 Embryonic and adult stem cells encapsulation forcell based therapy and cancerStem cells are potentially the ultimate source of transplantable cells for many differenttissues. A major obstacle in the clinical use of stem cells is their possible immunogenicity. Ourtechnology's innovative approach is to entrap the cells in capsules made of biocompatiblepolymers. This approach was specifically designed to take advantage of the immortality ofthese cells, while avoiding any possible immune response or the formation of teratomas.These capsules protect the cells from the immune system and act as a mini bioreactor,allowing them to secrete the engineered factor or natural therapeutic near sites of interest.

STM-0988 Tissue engineering of vascularized cardiacmuscle from human embryonic stem cellsTissue engineering is the use of a combination of cells, engineering and materials methods,and suitable biochemical and physio-chemical factors to improve or replace biologicalfunctions. This technology introduces a novel approach for generating vascularized humancardiac tissue in vitro. The engineered human cardiac tissue exhibited typical structural andfunctional properties of early-cardiac tissue. In addition, this innovative technology mayprovide unique applications for tissue replacement therapy and stem cell research.

STM-1132 Suspension culture for undifferentiated human iPS cellsInduced pluripotent cells (iPS) are cells derived from somatic cells that had shown the abilityto differentiate into each cell type of the adult body. However, any future use of these cells inclinic or industry requires efficient defined control system. Technion researchers havediscovered a unique suspension culture system for iPS cells consisting of serum replacementsand growth factors, allowing their continuous growth in the undifferentiated state.

STM-1136 Co-derivation and expansion of vasculogenic pericytesand endothelial cells from human ESCs and iPSTechnion researchers have discovered a method for efficient, simple and inexpensive co-derivation of the two blood vessel cellular components: pericytes and endothelial cells, from asingle pluripotent cell source. The robust expansion of mature vasculogenic cells, derivedfrom pluripotent cells has the potential to achieve sufficient cell numbers for clinicaltransplantation.


Stem Cells

STM-1148 Pancreatic progenitor enrichment of hES cell culture by GLUT2 sortingType I diabetes mellitus is caused by an autoimmune destruction of the insulin-producing βcells. The major obstacle in using transplantation for curing the disease is the limited sourceof insulin-producing cells. The earliest human pancreatic progenitors are marked by thetranscription factor pancreatic duodenal homeobox (PDX1). In normal β cells, PDX-1transactivates the insulin gene and other genes involved in glucose sensing and metabolism,such as GLUT2 and glucokinase. Several protocols have been tested, in order to increase thePDX1 expressing population in differentiating human embryonic stem cells (hES) or humaninducible pluripotent stem cells (iPS), in an attempt to obtain pancreatic progenitors cellswhich may further develop into insulin producing cells.

STM-1209 Novel method to generate Induced Pluripotent Stem (iPS) cellsfrom keratinocytes from human plucked hair follicleInduced Pluripotent Stem (iPS) cells are human somatic cells that have been reprogrammed toa pluripotent state, resembling human embryonic stem cells. The iPS cells are mostlyproduced from fibroblasts derived from the skin, a painful procedure that may be problematicin certain patients. Technion researchers have discovered a non-painful method forproduction of iPS cells from the keratinocytes of the outer root of human hair.

STM-1234 Suspension culture for undifferentiated human iPS cellsInduced pluripotent cells are pluripotent cells derived from somatic cells. Similar to humanembryonic stem cells, they differentiate into each cell type of the adult body. This inventionpresents a new method of culturing induced pluripotent cells, which may be suitable forclinical and industrial needs. The field of induced pluripotent cells has the potential todramatically change the treatment of human disease, but the traditional method of culturingthose cells is not compatible with any practical future use of them. Thanks to this newtechnology, it has become possible to culture induced pluripotent cells in a 3D structurewithout waiving any of the typical features of those unique cells. This is a huge step in thepassage to mass production of induced pluripotent cells for therapeutic ends.

STM-1283 Production of corneal tissue equivalents from human pluripotent stem cellsIn severe cases of corneal diseases such as total limbal stem cell deficiency, allo-grafts areobtained from patient’s relatives or from post mortem donors. This approach is commonlyused for years. However, shortage of donors and graft rejection are major drawbacks of thisapproach. Our novel invention is based on the production of corneal cells from humanEmbryonic Stem cells (hES), allowing the production of unlimited amount of corneal epitheliaready to be transplanted into injured eye of patient.


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Healthcare > STEM CELLSFOOD AND NUTRITION



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Stem Cells

STM-1290 Novel method to derive Extracellular matrix (ECM) from humanembryonic stem cells (hESCs) and human pluripotent stem cells(iPSCs) for regenerative medicine applicationsThe extracellular matrix (ECM) composition affects the cell attachment, migration,proliferation and 3D arrangement. This new invention uses differentiated human EmbryonicStem cells (hES) or human induced Pluripotent Stem cells (iPS) to generate ECM for surgicalapplications. This new invention may be used as a biological a-cellular scaffold with theadvantages of homogeneity, availability, bioactivity, biocompatibility and safety for surgicalapplication.

STM-1330 Establishment of an hESC-based model as an ex vivo experimentaland anti-cancer drug testing platformOne of the main limiting impediments in establishing personalized cancer therapy has beenthe lack of pre-clinical experimental models. In the present invention we propose the use ofbiocompatible materials which comprise a scaffold and the creation of an ex vivo 3D tissuelike structure. The new model will be used as an animal-free convenient study oftumorigenesis processes and for the development of tailor maid anti-cancer drug therapy.

DDL-1161 Cell-derived liposomes for drug-deliverySee ‘Drug Delivery‘, page 21

Food and Nutrition

NUT-0833 Casein micelles for encapsulation of hydrophobic compoundsA novel approach is proposed to harness casein-micelles (CM), which are naturalnanocapsules of essential nutrients for the neonate, by incorporating nutraceuticals in theircore. The potential benefits include supplementation of nutraceutical substances (NS) via astaple food, such as milk, with minimal effect on its functional and sensory properties,enrichment of non-fat milk products with fat-soluble micronutrients (e.g. vitamins, D,A,K,E,lycopene, omega-3 fatty acids etc.), and protection against their degradation duringprocessing and shelf life.

NUT-1015 Nano-Encapsulation of additives in Beta Casein assemblies for enrichment offoods, beverages and soft drinks including clear drinksThe invention is the ability to encapsulate beneficial food additives within beta-caseinassemblies either below or above the protein pI, and thus utilize them as vehicles forchallenging delivery tasks, such as via transparent beverages and other foods and drinks,particularly clear, nonfat acidic beverages. The beta-casein micelles may be loaded withhydrophobic or other nutraceuticals for enrichment of nonfat, low fat and other foods andbeverages including clear ones, without compromising transparency, or other sensorialproperties, while providing stability and protection to the encapsulated nutraceuticals.

Healthcare > FOOD AND NUTRITION


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Food and Nutrition

NUT-1051 Nano-complexes of beta-lactoglobulin and polysaccharidesas vehicles for hydrophobic bioactive moleculesAlthough foods and drinks are enriched today on a wide basis, enriching with hydrophobiccontent remains a problem. When enriching clear drinks the problem farther complicatessince except that the method should protect and solubilize the enriching hydrophobicingredients, the drink must also maintain its quality of transparency. In this inventioncompositions and methods for the formation of nanoparticles useful for carrying biologicallyactive molecules were developed. Moreover, this invention provides a solution to clear drinksenrichment with hydrophobic biologically active molecules.

NUT-1076 Addition of Prolactin to infant formulasBreath-feeding supports the provision of Prolactin, which plays an important role inregulating calcium absorption in mammals during neonatal, and may have otherphysiological functions as it can be absorbed in the intestine of neonates. The presentinvention suggests the addition of human Prolactin to infant's formula in a concentrationsimilar to that present in human milk in order to make it more similar to human milk andenjoy the major benefits of Prolactin.

NUT-1314 Maillard reaction-based nanocapsules for protection ofwater-insoluble nutraceuticals in clear drinksIn the modern world there is a rise in public awareness for healthy nourishing food and agrowing demand for enriched food. The present invention proposes to formnanoencapsulation-agents by Maillard reaction, for the solubilization, stabilization andprotection of poorly water soluble nutraceuticals. This novel invention can be used forenrichment of clear beverages while keeping the label of natural ingredients only.


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CHM-0599 Efficient synthesis of a polyacene monomerAn efficient method has been developed for synthesizing a monomer that, whenpolymerized, is anticipated to exhibit directional (i.e. anisotropic), conductivity substantial(possibly immense) mechanical strength, and possibly even room temperaturesuperconductivity. These polymers are named polyacenes. Possible applications include VLSIinterconnects, long distance transmission lines, MRI/NMR, RF, and microwave filters,among others.

CHM-0794 Ceramic coating on dental implant abutmentsDental abutments serve as the base on which the dental crown is fitted. They are connectedto the dental implant, which is integrated into the bone, via a screw, creating the implant-abutment-crown complex. Abutments are generally made of titanium or titanium alloyTi-6Al-4V. In order to decrease healing time, which takes several months, and also foraesthetic reasons, a ceramic coating made of alumina or alumina-zirconia on the abutment isneeded (Later the crown is built over the coated surface). However, the ceramic on metallicsubstrate coating process is still difficult to achieve, thus most of the abutments currently inuse have no coating. Our invention relates to a method for ceramic coating of a metallicsubstrate using a laser sintering process.

CHM-0989 Low cost onsite generation of high purity oxygenOxygen generators are important devices with many applications. Current on-sitegenerators separate oxygen from the air using adsorption. These generators provideinsufficient oxygen purity for most applications, in particular when producing high flowrates. Our technology uses a ceramic membrane that allows for fast generation of highquality oxygen at practically 100% concentration under any desired flow rate. Thisinvention can be applied to several industries and applications such as: medicine, chemicalmanufacture, coal gasification, oxyfuel combustion, fish farms, aircraft, gear for traumamedicine, SCUBA or other breathing apparatuses.

Engineering &Physical Sciences



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Engineering & Physical Sciences > CHEMISTRY AND MATERIALS SCIENCE

Engineering&PhysicalSciences


CHM-1065 Barium titanate layer produced by aqueous suspensioncathodic electrophoretic depositionBarium titanate (BaTiO3) is one of the most important ceramic materials used in electronics.As an intrinsic ferroelectric material it can be utilized for various applications like multilayercapacitors, grain boundary capacitors, low-temperature sensors and thermistors. There is agrowing need for efficient methods of producing barium titanate layers, particularly if theyare thin and crack-free. This method allows for the preparation of thin, whole layers evenin complex shapes without the use of extremely toxic solutions currently in use inother methods.

CHM-1107 Facile production method of novel family of highlycatalytic tridentate ligand complexesThis invention describes the development of novel methodology for the synthesis of a newclass of pincer ligands. Pincer ligands exhibit unusual thermal stability and have been foundto be extraordinarily useful in a variety of transition metal-catalyzed processes, as well as incoordination, mechanistic, synthetic and supramolecular chemistry, nanoscience, and thedevelopment of sensors and molecular switches. The usefulness of this technique and theresulting ligands have been demonstrated with extraordinary catalysis in the Heck reaction, acommon reaction in many commercial chemical synthesis processes.

CHM-1159 Calixurenes – novel binding moleculesThere are four main known families of macrocyclic host molecules based on specific host-guest reversible binding that are employed in a wide range of applications in chemistry,biology, food industry, electronics or printing. Despite this, for more than a decade, no newfamily of macrocyclic host molecules has been discovered and each of the knownmacrocycles is usually limited to specific applications according to its chemical nature andbinding properties. These new molecules called Calixurenes are the first binding macrocyclesthat contain thiourea combined with aromatic fragments and phenolic functions. This uniquecombination of functional groups in the same molecule is expected to produceunprecedented binding strength with high selectivity to almost any metal in any oxidationstate as well as binding properties expected to be independent of the environment.

CHM-1198 Novel austenite stainless steel surface hardening treatmentAustenitic stainless steel alloys have many desirable properties but suffer from bad resistanceto wear limiting their use to only static applications. This deficiency can be overcome withsurface treatments; however, the conventional nitriding treatment performed at regulartemperatures destroys the corrosion resistance of the metal, which is one of its mainadvantages over other alloys. Low temperature nitriding preserves the corrosion resistancebut causes high internal stresses resulting in cracking of the hardened surface. This novelprocess allows for austenitic stainless steels to be treated for wear resistance up to 50 µmdepth without cracking, while maintaining their resistance to corrosion, creating a materialwith advantageous properties for a wide variety of applications.




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CHM-1202 Low-cost aerocellulose production; All-cellulosereinforced aerocellulose compositeAerogels are a class of highly porous materials which are characterized by their low solidcontent. Amongst this class of materials is aerocellulose which is produced from cellulose.Cellulose constitutes 70% of Earth’s biomass and is therefore a key player in the pursuit toreplace oil-based products with products made from sustainable raw materials. Applicationsfor aerocellulose products range from acoustic or thermal insulation to audio membranes, togreen filling material for diapers.

CHM-1236 Liquid droplet elastomerA liquid droplet elastomer is a novel, liquid-filled rubbery polymer which combines anelastomer with individually encapsulated micron-scale droplets of liquid or gel. This low-costand scalable process based on Pickering emulsions and polyHIPEs produces liquid-filledcapsules with capsule walls capable of withstanding repeated mechanical and thermalstresses without failure due to the high level of liquid retention. This innovative technology ishighly customizable and lends itself to a wide range of applications including thermal andmechanical insulation, antibacterial medical equipment and fire-resistant cladding.

CHM-1251 Production of iodides from carboxylic acidsProcess summary: R-COOH → R-I, when R = alkyl, aryl. This is a practical innovative methodfor the preparation of organic iodides from alkyl or aryl carboxylic acids. This novelenvironmentally-friendly process utilizes commercially available iodination agent in a simple,one-step process that produces high yields of high-purity organic iodides. The clean reactionand simple workup allow for use of the iodine products as an intermediate in subsequenttransformations immediately after reaction without any isolation or purification procedures.

CHM-1272 Novel transparent conducting electrodes (TCOs)Transparent conducting electrodes are crucial components in any optoelectronic device likephotovoltaic cells or flat-panel display screens. Organic solar panels or organic displays havemany advantages over traditional versions. They are thinner, lighter, more flexible, and canmore easily be produced in a wider range of sizes. Additionally, organic displays are brighterand more energy-efficient and have a wider field of view than traditional displays. Thistransparent electrode created through a meticulously controlled process affords a higherperformance, more energy-efficient coupling between the organic and inorganic componentsof these products and is an optimal choice for incorporation into organic photovoltaic cells,organic displays or OLED‘s.



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MAE-1046 Tactile feedback mechanismThis invention uses local changes in pH caused by electrical current in a solution to createlocal topographical changes on a surface. Common applications include Braille displays andtactile feedback for touch-screen displays.

CHM-0496 Ultra-rapid texturing of silicon for solar panel productionSee ‘Energy‘, page 9

CHM-0665 Copper CMP slurry compositionSee ‘VLSI and Semiconductors‘, page 61

CHM-0708 Negative fullerene ion beams generation - method and apparatusSee ‘Nanotechnology‘, page 49

CHM-0809 Exploitation of the ordering effect in liquids adjacent or confined by crystals toachieve novel structures during liquid phase epitaxial growthSee ‘VLSI and Semiconductors‘, page 62

CHM-1054 Novel p-dopant for organic semiconductorsSee ‘Nanotechnology‘, page 49

CHM-1075 Seedless copper electroplating for Damascene processSee ‘VLSI and Semiconductors‘, page 62

CHM-1097 Microstructure control of ceramic matrix nanocompositesSee ‘Nanotechnology‘, page 49

CHM-1307 Electrospun metal and composite carbon-metal nanofibersSee ‘Nanotechnology‘, page 50

COM-0619 Gamma ray detectorSee ‘Sensors‘, page 60

ENE-1167 Autonomous natural gas reformer for on-demand andon-site hydrogen generationSee ‘Energy‘, page 11

MAE-0565 Voltage and light induced strains in porous crystalline materialsSee ‘MEMS and NEMS‘, page 48



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CHM-0676 Determination of thin film topographyThin film metrology is extremely important in QA, inspection and process control procedures(e.g. in the semiconductors industry). Our three-beam interferometry compact system allowsa low-cost, non-destructive, highly accurate measurement of thin film thickness andtopography, with depths as thin as 2nm.

CHM-0804 Seamless dual-mode ACPD non-destructive testing (NDT)In many industries, structural integrity is paramount and inspections are a must. Therefore,non-destructive testing or inspection (NDT) is an important part of many productionprocesses and critical for structures and vehicles during their service life. This ACPD(alternating current potential drop) technology is a low-cost NDT method, which improvesupon existing ACPD tests that are limited to locating emerging surface cracks, withoutproviding information on their depth. By using the ACPD method in a tomographic-likemode, one can quickly and efficiently map the size and location of cracks anywhere in aconducting structure, based on a seamless integration of thick and thin skin testingconfigurations.

COM-0884 Object distance and brightness estimationOptical imaging and ranging technologies are used to acquire the depth and brightness ofeach object point in a given field of view. Such technologies are used in numerousapplications, from home digital cameras to microscopy systems. Existing methods exhibitdepth of focus resolution for range estimation. Our technology achieves higher distanceaccuracy in a wide field of view.

COM-1139 Highly sensitive (single photon) detector for IR wavelengthsThere is a growing need for enhanced sensitivity in the measurements of optical phenomena.The most sensitive of optical detectors, single photon detectors (SPD’s) can be used toenhance medical and diagnostic imaging, chemical analysis, laser scanning, laser ranging,material characterization, quantum information processing and communication, and scientificresearch. Most SPD’s are incapable of detecting photons in the infrared wavelength andthose that are, are usually plagued by poor quantum efficiency or require very low operatingtemperatures (about 10K). However, this invention is an important step closer in the effort todetect a single infrared photon at almost room temperature with high quantum efficiency.


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COM-1157 Novel and powerful enhancement of measurement systems‘ resolutionThis invention is a novel and powerful method which enables the enhancement ofmeasurement equipment resolution beyond its physical limits in cases where the signal beingmeasured is sparse in a known basis. Most measure objects (natural and artificial) are sparse,i.e., they contain many coefficients close or equal to zero when represented in some basis.This is the first time this approach has been employed to tackle this problem. The method hasbeen demonstrated to enhance the resolution of an optical microscope by a factor of ~10beyond the fundamental diffraction limit. Similar resolution enhancement capabilities havebeen shown, where a laser pulse consisting of three 150 ps subpulses has been successfullyand accurately reconstructed following acquisition by a "slow" photodiode with a 1000 psrise time. This technique is very general, and can be utilized in any sensing/ detection/ dataacquisition scheme.

MAE-1038 Acoustic particle focusingThis device enables acoustic focusing of micron and submicron particles in air. It can be usedseparately or in combination with aerodynamic lens arrays as an inlet to on-line single-particleanalyzers including aerosol time-of-flight mass spectrometers, which are widely used inanalytical chemistry, atmospheric dust analysis, biological detection, pharmaceuticalmanufacturing, and engine exhaust-gas analysis. The device allows for the supply of aconcentrated (low gas volume, highly loaded) aerosol stream to on-line single-particleanalyzers, allowing for a reduction in the required pumping power normally needed tosustain vacuum conditions.

CHM-0620 Variable lenslet arraySee ‘Optics and Lasers’, page 52

CHM-0802 Single sided probe for ESR imaging of semiconductorsSee ‘VLSI and Semiconductors’, page 62

CHM-1173 Direct and nondestructive chemical analysis of solid and liquid samplesSee ‘Sensors’, page 59

COM-1361 Superconducting nanowire single photon detector on a tip of an optical fiberSee ‘Optics and Lasers‘, page 53

COM-0751 Automatic re-meshing from a 2D grid to a 3D modelof genus-n based on topological analysisSee ‘Signal, Audio and Image Processing‘, page 65

MAE-0730 Active detection of asymmetry in turbomachinery via asynchronous excitationSee ‘Mechanical Systems‘, page 47



Engineering & Physical Sciences > MECHANICAL SYSTEMS

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Mechanical Systems

COM-0995 Ferroelectric stack actuator and shape control algorithmPiezoelectric stack actuators are a common choice for micro- and nano-positioning systems.However, they are limited in terms of travel range (stroke). Our advanced piezoelectric-ferroelectric actuator has a travel range-to-length ratio up to six times greater than traditionalpiezoelectric stack actuators. Furthermore, the active layers in the advanced stack arecontrolled separately or in groups and are assigned with either a de-poled or a fully polarizeddomain state. This feature minimizes vibrations, allows for a controllable and extended travelrange, and ensures that the nano-scale positioning accuracy is maintained. Applications varyfrom microscopy to fuel injectors or from digital cameras to structural systems.

MAE-0632 Increased life for gas filters using acoustic fieldsGas filters clog over time: the captured particles gradually build up in layers and clog thefilter. This leads to a pressure drop across the filter, which results in increased energyconsumption. Common methods of filter cleaning require mechanical vibration, air jets orreverse flow. However, vibration increases filter material wear, and reverse flow methods addcomplexity and significantly increase price. Our method uses sound waves, in a simple andlow cost setup, to extend the service life of gas filters by up to threefold.

MAE-0682 Electrostatic modulation of surface roughnessThe roughness of surfaces is an important parameter, affecting many issues. For example,smooth planar surfaces may be used to reflect and redirect a beam of light. In contrast,rough surfaces may be used to disperse a light beam. This innovative technology useselectrostatic forces to change the roughness properties of a surface creating a mechanism foron and off switching of surface roughness creating a desirable enabling technology that canbe used in many fields for optical applications, drag reduction applications and many more.This technology can be used to make a micro-mechanical switch with nanosecond responsetimes and no moving parts.

MAE-0730 Active detection of asymmetry in turbomachinery via asynchronous excitationHigh-speed rotors are sensitive to cracks and small deformations which can cause billions ofdollars in damages and injuries every year. This invention is the first to accurately identifysmall cracks and similar deformations in rotating bodies while the machine is running andwithout requiring disassembly of the machine.

MAE-0862 Highly sensitive, real-time structural monitoringStructures such as aircraft, ships and bridges rely on rivets and joints which are constantlyundergoing wear and therefore must be continuously examined. Our technology aims atmonitoring the health of critical joints by utilizing wave components previously consideredunusable noise.


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Mechanical Systems

MAE-0935 Miniature Cryogenic CompressorThermal imaging devices, mobile sensing platforms and other advanced equipment requireminiature compressors. Piezoelectric actuators have many favorable properties, but have notyet been successfully used in miniature compressors, mainly due to small stroke length. Ourtechnology utilizes the piezoelectric phenomenon together with hydraulics to produce anefficient and reliable miniature-sized gas compressor for various uses, including cryogenics.

CHM-0804 Seamless dual-mode ACPD non-destructive testing (NDT)See ‘Measurement Methods and Systems’, page 45

MAE-1029 Simplified fuel atomizationSee ‘Energy‘, page 12

MAE-1038 Acoustic particle focusingSee ‘Measurement Methods and Systems’, page 46

MEMS and NEMS

MAE-0565 Voltage and light induced strains in porous crystalline materialsDespite large efforts made in the last few decades, progress in the development ofdeformable mirrors has been slow, and there are only a few available types. The high price ofthese mirrors is an indicator of difficulties in their manufacture, such as complex construction,non-repeatability and non-uniformity. However, a simple silicon wafer, on the back of whichporous silicon is etched, can serve as an agile mirror. Because porous silicon can induce stressor strain using electrical or optical signals it could be used in many technologies likecommunication devices, scanning microscopes, printers and any other place where onerequires mechanical movements in response to electronic or optical signals. In addition,because porous silicon is piezooptic and optostrictive it can replace existing elements withthese properties along with piezoelectric and electrostrictive elements.

MAE-0918 Low-friction molecular rotary motorsNanomotors are becoming increasingly important as nano-mechanical systems are continuingto develop. Molecular rotors can be attached to a solid support and used in a variety ofapplications such as energy converters (motors) biochips and biosensors. The most importanttraits for a molecular rotary motor are unidirectional motion and high speed rotation withlow friction. This nanomotor is able to achieve high-speed motion with minimal frictionminimizing dissipation of energy by creating rotation with a very low energy barrier using arotator-stator couple with repulsive interactions between them. A device of this type isunprecedented in the micro level but has already been applied in the macro scale in maglevsuspension systems.



Engineering & Physical Sciences > MEMS AND NEMSNANOTECHNOLOGY

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MEMS and NEMS

COM-0636 Low cost CMOS thermal/IR imaging sensorSee ‘Sensors’, page 60

MAE-0682 Electrostatic modulation of surface roughnessSee ‘Mechanical Systems’, page 47

Nanotechnology

CHM-0708 Negative fullerene ion beams generation - method and apparatusThe production of neutral and negative molecular ion beams is of considerable importance indiverse areas of physics, in the production of nano-electro-mechanical and nanophotonicssystems, synthesis of new materials, electric propulsion devices, fundamental science areas assurface chemistry and catalysis, organic chemistry, and biology and other fields. This systemionizes neutral C60 molecules as they pass through a ceramic capillary giving a very pure,bright and focused ion beam with a narrow energy spread.

CHM-1034 Optical tweezersNew devices and technologies rely on “micro pumps” to transport fluids. Our technologyallows beams of light to manipulate the local density of particles suspended in liquids orgases. It can be used to control the physical and chemical properties of the fluid, and tomanipulate particles of various sizes, ranging from micrometers to nanometers. At the microand nano scale, the optical pump has a higher efficiency as compared to rotating mechanicalpumps, while having no moving parts. This technology has applications in nanotechnology,micro-chemistry, holography, and many more.

CHM-1054 Novel p-dopant for organic semiconductorsHole transporting organic semiconductors (OSCs) are necessary for the realization of lowvoltage and efficient organic light-emitting diodes (OLEDs) whose advantages over LCDdisplays are widely recognized. P-doping enhances such hole transporting properties.Halogenated C60 derivatives, previously unexploited in organic electronics, act as highlyeffective electron acceptors, or p-type dopants, for OSCs. In addition to facilitating high holeconductivity, these dopants were found to be stable and avoid the toxicity problemsconnected with usual organic acceptor dopants.

CHM-1097 Microstructure control of ceramic matrix nanocompositesA method facilitating a way to obtain ceramic nanocomposites via a safe and very low costprocess yielding ceramics with improved strengths and with a significantly improved Weibullmodulus. The material also shows remarkable wear properties. Example applications includeceramic cutting tools, ballistic armor, car brake pads, parts for textile fabrication, advancedceramics for a multitude of applications in the semiconductor manufacturing industry (e.g.capillaries for wire-bonding), and electronic components.


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Nanotechnology

CHM-1182 Novel durable tagging agentsCertain chemicals can be used to make explosives but are so common and sold in such largeamounts that tracking sales or thefts of small amounts is quite a challenge. Adding taggantsto explosives and substances used for their preparation would increase the probability oftracking them to their manufacturer and origin in case of terror attacks and other criminaluses. This technology offers microparticle taggants that are low-cost, durable, and do notchange the chemical properties of their host chemicals so they can still be used for theiroriginal intended use.

CHM-1307 Electrospun metal and composite carbon-metal nanofibersThere has been a growing effort to manufacture nanometric fibers from polymers, carbon,ceramics and metals due to a wide range of potential applications in optics, electronics,optoelectronics, filtration and separation, catalysis, micro- and nano-sensors, and also alternativeenergy. Metal fibers of submicron diameter are especially interesting due to their high electricalconductivity and mechanical stability. Conventional methods allow for the production of metallicnanofibers with a short overall length and a relatively small aspect ratio. The presentedinnovative method provides for the manufacture of long, high-quality fibers with a large aspectratio and enhanced mechanical stability.

COM-0969 Membrane computing system and methodP-Systems are theoretical computational systems, which when realized will be capable ofsolving NP-complete problems in linear or polynomial time. Our technology is currently theonly existing solution for computation of P-Systems.

CHM-0501 Source of intense coherent high-frequency radiationSee ‘Optics and Lasers’, page 52

CHM-0665 Copper CMP slurry compositionSee ‘VLSI and Semiconductors’, page 61

CHM-0989 Low cost onsite generation of high purity oxygenSee ‘Chemistry and Materials Science’, page 41

CHM-1084 Silicon air batteriesSee ‘Energy’, page 9

CHM-1202 Low-cost aerocellulose production; All-cellulosereinforced aerocellulose compositeSee ‘Chemistry and Materials Science’, page 43

CHM-1272 Novel transparent conducting electrodes (TCOs)See ‘Chemistry and Materials Science’, page 43



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Nanotechnology

MAE-0918 Low-friction molecular rotary motorsSee ‘MEMS and NEMS’, page 48

RES-0870 Electrical control over Antibody-Antigen bindingSee ‘Research Equipment’, page 32


COM-0954 Polarization-multiplexing based passive optical networksPassive Optical Networks (PON) are used for high speed digital communication such as video,data and voice. Currently, massive deployment of optical fiber infrastructure is underway toenable this technology. This creates problems of inflexibility to future adjustment of thenetwork due to the growing number of users and massive data. Our technology provides acost effective solution that works on the existing infrastructure.

COM-0966 Blind reconstruction of multi-band analog signalsReconstruction of multi-band signals is a challenge in the field of signal processing. Some oftoday‘s methods require a high sampling rate, and obtaining such a rate requires expensivesystems. Other methods require prior knowledge, which is not always available. Ourtechnology enables perfect reconstruction of multi-band analog signals at a minimal samplerate and with no need for prior information.

COM-0970 Distorted signal recoveryReconstruction of a signal from its distorted samples is a common scenario in acquisitiondevices such as sensors and detectors. Current methods developed for these situations arebased on idealized assumptions or are limited in application. Our technology is practical andapplicable to numerous systems.

COM-0987 BENoC - Bus enhancement NoCNetwork on Chip (NoC) is the future of VLSI interconnects. The technology enables improvedchip performance in numerous aspects such as power consumption and data transfer rate.Several drawbacks are to be worked out to accelerate its acceptance as an industry standard.Our technology solves some of these issues and increases system operation efficiency at alow cost.

COM-1106 Compact and wideband tapered slot antenna for WPAN applicationsThe communication industry is growing at phenomenal rate. A clear trend is the futuredevelopment of Wireless Personal Area Networks (WPAN) operating in the 60 GHz millimeter-wave band. WPAN devices require low-cost antennas that are not only compact andintegrable with RF modules, but also efficient and wideband. Current technologies areexpensive and exhibit poor performance rendering them unsuitable for many applications.Our technology provides a generic and efficient solution to this growing need.


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COM-1122 Wideband analog to digital conversion and low rate baseband processingRadio frequency (RF) technology enables the modulation of narrowband signals through highcarrier frequencies. Conventional Analog to Digital Converters (ADC's) have inherentbandwidth and maximal frequency limitations. Our novel technology enables the design ofan ADC device for input in the wideband regime of over 20 GHz and for generation of abaseband sequence which corresponds to any specific region of the spectrum without theneed for prior reconstruction.

COM-0500 Wavelength-selectable laserSee ‘Optics and Lasers’, page 53

COM-1295 Three-photon counting by three photon absorptionSee ‘Sensors’, page 60

Optics and Lasers

CHM-0501 Source of intense coherent high-frequency radiationLaser X-ray beams can be used for CT scanning, micro-devices fabrication and even forindustrial cutting and CNC applications. A laser X-ray beam differs from a regular X-ray beamin that it is coherent and focused. Our technology involves a method for producing high-frequency (e.g. soft X-ray) coherent radiation using a compact device the likes of which arenot currently available on the market. A laser X-ray emitting system can replace conventionalX-ray emitting systems in all of its functions while using less power and creating far lessexposure to ionizing radiation.

CHM-0620 Variable lenslet arrayMeasuring wave front distortions is widely practiced in optics and is essential for adaptiveoptics, optical shop testing, wafer measurements and other fields. Conventional wave frontsensors have difficulty measuring wave fronts under severe conditions such as low light level,fast scale variations, large aberrations, wide dynamic range, both lateral and in depth anddiscontinuities in the wave front. This unique invention uses a variable lenslet array to sensewave fronts even under these severe conditions and meets this need in a simple and effectiveway without any mechanical motion.



Engineering & Physical Sciences > OPTICS AND LASERS

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Optics and Lasers

COM-1361 Superconducting nanowire single photon detector on a tip of an optical fiberSingle photon detectors and very sensitive photon detectors are needed in various fields, suchas quantum communication, space communication, astronomy, molecule sequencing, motiondetection, artificial atom probing and many others. The technology of SuperconductingNanowire Single Photon Detectors (SNSPD) is considered to be a viable candidate for highrate detectors with low dark count. However, current SNSPDs suffer from low detectionefficiency. This invention offers a novel design of a SNSPD fabricated on a core of a singlemode optical fiber and inside an optical cavity. This new and innovative design allows forresonant photonic cavity enhanced detection leading to almost perfect detection efficiency. Inaddition, the manufacturing and operation costs for this detector will be much lower than forconventional existing systems.

COM-0500 Wavelength-selectable laserFiber-optics is the leading technology for high-bandwidth communications such as Internet,telephones and cable TV networks. Current commercial transmission using a single fiber witha single wave-length can reach throughputs as high as 10 Gbps. Our technology overcomesthis limitation by operating a laser with the ability to rapidly switch between differentwavelengths. Low fabrication costs and nanosecond switching times allow for a cost-effectivesolution for increasing the capacity of existing fiber infrastructure.

COM-0679 Passive Q-switch laserEye-safe lasers have recently become popular in laser radar, three-dimensional scanning,targeting, and communication applications. Such applications require the laser to operateunder Q-switching, which can generate a laser pulse with duration on the order of tens ofnanoseconds, and a peak power on the order of a megawatt. Conventional active Q-switchesare not entirely based on optics, and therefore usually have a relatively slow operation timeand a limited bandwidth. These systems require external electronics, additional optics, andmagnetic field or acoustic wave accessories which increase the physical size and can also addexpenditures to the cost of the switching device. This innovative device utilizes passive Q-switching making it both compact and simple without the need for any auxiliary electronics.Since it has no external control, it has a high capability for integration, in terms ofmanufacturing, operation, fabrication cost, system size, and weight.

COM-0734 Method for acquisition of video with enhanced resolutionIncreasing video resolutions require higher data transfer rates, which can eventually lead tobottlenecks in recording devices. Our technology enables the capture of video at higherresolutions and frame rates using low and midrange camera hardware. Using a sequence ofmixed high and low resolution frames, our algorithm constructs a fully high resolution video.In cases when real-time processing is not required, there are no additional hardwarerequirements.


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Optics and Lasers

COM-0753 Optical noise-free microphoneThis invention is an innovative method to detect a person's voice while suppressing anybackground noise. The Optical Noise-Free Microphone (ONFM) is a low-cost, simple and smalldevice that optically detects vibrations directly from the speaker’s skull or from other sound-generating objects such as musical instruments.

COM-0808 Efficient method of shaping a laser beamThe military industry, as well as those industries involved in the production of semiconductors,medical devices, and vehicles, need improved laser systems in order to satisfy growingcustomer demands. The efficiency of a laser system is determined by the laser beam powerand the resolution output at each point. Existing technologies to improve these qualities arelimited and only partially answer industry demands. We combine the advantages of currenttechnologies in a simple, low cost manner to maximize systems performance by shaping itslaser beam form.

COM-0945 LED-like photon pair sourceEntangled photons have the potential to provide improved signal-to-noise ratio (SNR) andimmunity to eavesdropping in communication applications. A source for such photons isnecessary for higher quality, more secure optical communications. However, current photonsource devices are impractical for industrial use. Our technology enables high performance,commercially viable entangled photon sources.

COM-1050 Optical logic gateFuture digital communication systems are expected to be faster and capable of transferringlarger amounts of data. As current electronically-based systems will not be able to handle thesedemands, alternative solutions are required. Optical networking is expected to provide fasterthroughput rates and wider bandwidth, but it requires extremely fast switches, which mustoperate in the pico-second range. Our optical gate opens the door to a fully-integrated, alloptical communications network.




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Optics and Lasers

COM-1158 Cancer diagnostic probeEffective diagnostics of cancerous cells during oncology surgeries is necessary for a successfultreatment. Currently, treatments in these fields often result in repeated surgery which put thepatient at risk and are costly. Therefore, providing the surgeon with a device which canaccurately identify cancer can save repeated surgery and treatment costs while providingbetter healthcare. Our technology enables a breakthrough, low-cost and easy to operatedevice for ensuring the removal of all cancer cells during surgery.

COM-1186 Semiconductor two-photon laserA laser based on emission of photon pairs has numerous applications. Such a device isvaluable for quantum communication and cryptography, medical imaging, optical inspectionsand more. Currently, Two-Photon Laser (TPL) technology is expensive, bulky and suffers fromlow performances, which make it impractical for industrial use. Our breakthrough technologyenables commercialization of TPLs.

MAE-0593 Space-variant subwavelength polarization gratingLaterally-varying polarizers have found application in a variety of fields including materialprocessing, tight focusing, polarimetry, particle trapping, particle acceleration anddevelopment of optical computers. However, with conventional polarizers, the transmissionaxes vary laterally in a discontinuous manner degrading the optical efficiency of the polarizer.This invention uses computer-generated space-variant subwavelength dielectric metal wiregratings for the formation of radially and azimuthally polarized light from a polarizer whosetransmission axis varies laterally in a truly continuous manner. By correctly determining thedirection, period and depth of the grating, any desired continuous polarizationcan be obtained.

MAE-0614 Space-variant subwavelength dielectric gratingPolarization measurements are important for a large range of applications such asellipsometry, bio-imaging, imaging polarimetry and optical communications. This methodenables the use of computer-generated space-variant subwavelength dielectric gratings forthe formation of radially and azimuthally polarized light. By correctly determining thedirection, period and depth of the grating, any desired continuous polarization can beobtained. Furthermore the continuity of our grating ensures the continuity of the transmittedfield, thus suppressing diffraction effects that may rise from discontinuity. Our gratings arecompact, lightweight, flexible in design and have high transmission efficiency. The gratingshave been used in the laboratory to achieve experimental measurements of polarized andpartially polarized CO2 laser radiation at a wavelength of 10.6 µm.


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Optics and Lasers

MAE-0634 Geometrical phase optical elements with space-variant subwavelength gratingsThere has been a growing interest in helical light beams for applications like optical MEMS,optical inspection, atom or macroscopic particle trapping and other fields. Conventionalsystems for forming helical beams are generally cumbersome and complicated and sufferfrom high aberrations, low efficiency or instabilities. This technology was able to demonstratethe Pancharatnam-Berry space domain resulting from the geometrical phase thataccompanies space-variant polarization manipulation using continuous computer-generatedspace-variant subwavelength dielectric gratings. By continuously controlling the localorientation and period of the grating, any desired phase element can be achieved.

MAE-0647 System and method for producing a light beam with spatially varying polarizationMethods of producing homogeneous linearly- or circularly-polarized light fields are wellknown. This technology allows for the complete polarization of a light beam in a spatially-variant manner efficiently and over a wide bandwidth so as to produce a light beam withradial or azimuthal polarization with respect to a given axis, which is impossible withconventional technologies.

MAE-0763 Space-variant polarization manipulation of a thermal emissionThis technology offers a method for space-variant polarization manipulation of enhancednon-directional thermal emission in a narrow spectral peak. This can be used to createthermal sources, for decoding thermal coding or for thermal management. The polarization isaccomplished by irradiating non-directional thermal emission on a sub-wavelength gratingsupporting surface phonon-polariton or surface plasmon-polariton and discretely controllingthe local orientation of the grating.

MAE-1112 Dilute nitride-based Quantum Well Infrared Photodetector (QWIP)Optoelectronic devices operating in the near infrared (NIR) to mid infrared (MIR) spectralrange offer a diversity of applications ranging from telecommunications to chemical sensorsfor pollution detection, chemical forensics, chemical and biological warfare, industrial processmonitoring, night vision and even medical diagnostics. However, conventional materialsystems and IR-detectors do not effectively meet these optical range needs. This inventionoffers a new type of IR-device in the NIR to MIR range, based on optical transitions to foreignatoms which when inserted into standard active layers in QWIP devices, affect electronicstates. Single element devices operating at ~1.5 µm at RT, that were fabricated and tested inour lab, demonstrate high responsivity of ~20 A/W, and signal gain of ~1000 (which is notrelevant for the dark current and dark current noise). This new type of device may potentiallyenable single photon detection at the NIR range.




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Optics and Lasers

MAE-1140 Nitrogen incorporation in atomic layer epitaxygrowth of InAsN/GaAs quantum wellsIn recent years, the dilute nitride alloys (III-V-N) has been the subject of intense theoreticaland experimental research effort because of their ability for band gap and band-offsetengineering, and thus have potential for a wide range of optoelectronic device applications.By optimizing the nitrogen content, the lattice constant and band-gap energy can be variedover a wide range tailoring the material’s properties to a specific application, such as near-infrared (IR) lasers and quantum-well IR photodetector (QWIP) devices. However, the growthof high-indium-content dilute nitrides using metal organic chemical vapor deposition(MOCVD), which is important for such applications, is not straightforward. This laboratory-tested method overcomes this difficulty and allows for the manufacture of high-qualitystructures tailor-made for specific optical communication devices.

MAE-1216 Tuneable XBn and nBn and PV IR detectorsThe ability to fine-tune the band gap of infrared detectors allows for multispectral imaging,which has many commercial military and civilian applications. However, conventionalmanufacturing methods are extremely limited in this field. This invention utilizes well-knownand well-studied properties of dilute nitrides to utilize PV, nBn and XBn structures and theirreduced working temperatures, to retain control over the band-gap energy of the III-V-Nsemiconductor active layer through control over its composition retaining the lattice-matching constraints. This laboratory proven method can pave the way for lattice-matched,compositionally tunable band gap active layers for infrared detectors with a cut-offwavelength between 3-5 microns or more.

MAE-1220 New active layer for GaAs-based lasersGreat efforts have been made toward achieving 1.3-1.55 µm emission from high-performance GaAs-based lasers for use in a wide range of commercial optoelectronic devices.Research has shown that controlling the band-offset and not just the band-gap is essential inorder to optimize the laser performance. This lab-proven technology succeeds in creating abi-layer structure that can be used as an active layer for a near infrared (NIR) laser. The layerdemonstrates high gain, low transparency carrier density, acts as an almost equal barrier forelectrons and holes and an equal lifetime for thermal escape – all necessary properties forcreation of an optimized NIR GaAs laser that can outperform existing commercial devices.

CHM-1034 Optical tweezersSee ‘Nanotechnology’, page 49

COM-0910 Deep nanopatterning FIB technologySee ‘VLSI and Semiconductors’, page 63

COM-0954 Polarization-multiplexing based passive optical networksSee ‘Networks and Communication’, page 51


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Optics and Lasers

COM-1157 Novel and powerful enhancement of measurement systems’ resolutionSee ‘Measurement Methods and Systems’, page 46

MAE-0565 Voltage and light induced strains in porous crystalline materialsSee ‘MEMS and NEMS, page 48

Security

CIV-1108 Automated detection of tunnel excavationCross-borders smuggling tunnels pose a very serious threat to security. Recent advances instrain measurement by Fiber-based Brillouin optical time domain reflectometry (BODTR), ledto the development of commercially available systems with sensitivity of less than 5µm andspatial resolution of 1m, thus enabling sufficiently sensitive device, which can detect tunnelexcavation through the strains the tunnel causes near the surface.

COM-1181 Compact direction finding antennaDirection finding antennas have numerous applications; however, the complexity of thetechnology has its price. The size of such antennas, cost of production and maintenanceinhibit the development of various applications. Solutions to these drawbacks are achieved atthe cost of performance. Our technology enables high performance, small size and low costDirection-Of-Arrival (DOA) antenna, suitable for existing as well as for new applications.

MAE-0791 Autonomous control scheme for unmanned aerial vehicle flocksThe use of armed unmanned aerial vehicles (UAVs) is on the rise. When several crafts are senton a mission, their communications bandwidth requirements make them vulnerable. Ourfully-autonomous management scheme for UAV flocks can overcome this weakness.

MAE-0877 Highly efficient spacecraft thruster - CAMILAA technology which can double the efficiency of available spacecraft and satellite thrusterswith minimal modifications. The unique design eliminates the common problem of “slowions” which significantly reduces the efficiency of existing thrusters.

MAE-1128 Agile kill vehicle against ballistic missilesTargeting and destroying long-range ballistic missiles is a highly critical task. Kill Vehicles (KV),such as the Israeli Arrow and American THAAD, are designed to intercept high-velocitytargets at altitudes as high as 150 km. However, new generations of ballistic missiles areable to employ evasive maneuvers to avoid being hit by KVs. Our Agile Kill Vehicletechnology enables maintenance of a high kill ratio even if evasive maneuvers are performedby the target.



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Security

CHM-1173 Direct and nondestructive chemical analysis of solid samplesSee ‘Sensors’ below

CHM-1182 Novel durable tagging agentsSee ‘Nanotechnology’, page 50

MAE-0862 Highly sensitive, real-time structural monitoringSee ‘Mechanical Systems’, page 47

MAE-1029 Simplified fuel atomizationSee ‘Energy’, page 12

Sensors

CHM-1173 Direct and nondestructive chemical analysis of solid samplesChemical analysis is usually performed in solutions or in the gas phase, while direct detectionof solids is much more difficult. This breakthrough spectroscopic method utilizing laser multi-photon ionization (MPI) is performed under ambient conditions and is suitable for directanalysis of solid materials providing rich spectral features that can be used for compoundidentification. This technology has applications in industrial process control (e.g.semiconductor wafers), in quality assurance (e.g., pharmaceuticals), in forensic applications(e.g., explosives, narcotics) and in several environmental monitoring applications. This novelmethod has been successfully laboratory-demonstrated and was used for the detection ofvarious organic compounds including explosives, narcotic drugs and polycyclic aromatics.

CHM-1238 Changing the properties of mechanical resonators bythe means of electron beam induced depositionFabrication and measuring processes involving electron beams (e-beams) in vacuumchambers are usually sensitive to organic contaminations, such as hydrocarbons. Organicmolecules interacting with the e-beam form polymerized nonconductive deposits, whichdisrupt normal image acquisition, cause charging effects, and interfere with microlithography.Therefore, monitoring of the contamination level before and during these processes isessential. The few contamination sensors that find use in the industry are not highly selectiveand measure the contaminations mainly in the gas phase, e.g., mass spectrometers and gaschromatographers, while the main source of the hydrocarbon molecules is the surfaceorganic contaminations. This invention utilizes a prominent mechanical property of thepolymerized carbon deposits, namely, the high surface stress, as a direct measure of theamount of the contaminations available locally in the vacuum chamber for the polymerizationprocess. Employing a microelectromechanical device whose resonance frequency is sensitiveto changes in the surface tension, a sensor is created that is fast, works in real time, and canbe calibrated.


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COM-0619 Gamma ray detectorGamma-ray detectors have wide applications in fields such as nuclear medicine,environmental monitoring and material testing. By analyzing emitted rays using a gamma rayspectrometer, diagnostically useful information can be obtained. Some of the methods usedfor the detection of gamma rays include Geiger counters, scintillation counters, neutrondetectors, semiconductor detectors and variants including CCDs. Our invention improves thefabrication process of detectors using an acoustic wave treatment. This allows forimprovements such as increased sensitivity and differentiation between energy levels of thedetected rays.

COM-0636 Low Cost CMOS Thermal/IR Imaging SensorToday‘s thermal imaging devices are expensive specialized products for niche markets. Ourtechnology, based on CMOS-SOI-MEMS, can reduce their production costs tenfold, resultingin 100$ or less per imager, enabling widespread use for numerous applications and markets.

COM-1102 CMOS-SOI-MEMS thermal sensors for THz imaginThis invention is aimed towards achieving a focal plane array for passive OR ACTIVE imagingin a wide bandwidth of 0.6-1.5THz - by pursuing a new approach and introducing multipleinnovations, one of which is based on uncooled thermally isolated CMOS SOI transistors(TeraMOS).

COM-1253 CMOS-SOI-MEMS thermal antenna for THz thermal imagingThermal antennas couple thermal radiation to thermal sensors by converting Electromagneticradiation directly into heat. Applications include THz sensors where the challenge is toachieve high efficient coupling between the thermal radiation irradiating large pixels and thetiny TeraMOS sensor described above. Additional applications include IR pixels where with thepresent invention the thermal time constant may be reduced significantly.

COM-1295 Three-photon counting by three photon absorptionPhoton counting is the key enabler of the revolution in experimental quantum optics, as wellas for a variety of quantum information applications achieved over the past decade. It alsoplays an important role in classical applications involving extremely low-light intensities in awide range of fields including biological imaging and optical communications. Significantefforts have been made to develop photon counters able to detect high photon numberstates which can provide unique solutions for enhanced-sensitivity metrology and quantumcomputing. This technology is a sensitive three-photon counter in which input photons areabsorbed as triplets by three-photon absorption (3PA) allowing for ultrafast detection ofphoton triplets and extraction of the temporal shape of a fsec pulse without direction-of-timeambiguity and with no need for spectral measurements.



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MAE-1057 Self balancing motorcycleMotorcycle riding has always been a dangerous and attention-demanding activity, especiallywhen compared to driving cars and other enclosed vehicles. The motorcycle’s unstable naturemakes it vulnerable to road hazards and emergency situations, and the consequences ofaccidents can be harsh. Our technology enables a motorcycle to balance itself, allowing formajor advances in road safety and autonomous robotics.

CHM-0620 Variable lenslet arraySee ‘Optics and Lasers’, page 52

COM-0753 Optical noise-free microphoneSee ‘Optics and Lasers’, page 54

COM-1181 Compact direction finding antennaSee ‘Security’, page 58

COM-1304 Blackbody as a THz emitter and a THz measurement andcharacterization set-up based on blackbody and THz filtersSee ‘Signal, Audio and Image Processing’, page 68

MAE-0935 Miniature Cryogenic CompressorSee ‘Mechanical Systems’, page 48

MAE-1112 Dilute nitride-based Quantum Well Infrared Photodetector (QWIP)See ‘Optics and Lasers’, page 56

MAE-1140 Nitrogen incorporation in atomic layer epitaxygrowth of InAsN/GaAs quantum wellsSee ‘Optics and Lasers’, page 57

MAE-1216 Tuneable XBn and nBn and PV IR detectorsSee ‘Optics and Lasers’, page 57


CHM-0665 Copper CMP slurry compositionChemical Mechanical Planarization (CMP) is one of the processes wafers undergo during chipmanufacturing. During CMP the wafer is polished by a polishing-pad, in conjunction with anabrasive and an electrolyte – the slurry – which protects the copper as well as mechanicallyscrapes the wafer surface. Our slurry composition improves VLSI production by preventing thecorrosion of copper throughout the CMP process. The technology enables better waferproduction yields.


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CHM-0802 Single sided probe for ESR imaging of semiconductorsSemiconductor devices have a complex 3D structure. There is a general need in the industryto have noninvasive high resolution 3D imaging of semiconductor devices. The inventionrelates to a unique, single sided electron spin resonance (ESR) micro-imaging probe forsemiconductor imaging with a 3D resolution better than 100 nm. Such images can be usedto identify the source of failure mechanisms (failure analysis, FA) in newly designed andfabricated chips, and for QA purposes of devices under production.

CHM-0809 Exploitation of the ordering effect in liquids adjacent or confined by crystals toachieve novel structures during liquid phase epitaxial growthMany modern electrical devices are manufactured through Very Large Scale Integration (VLSI)methods which integrate a large number of different electrical components on a single chip.Many of these components incorporate contact between different crystalline substances.Such contacts often contain defects due to a misalignment of the corresponding crystallinestructures which introduce inefficiencies into the manufacturing process and in some cases,prevent the use of certain materials altogether. A similar phenomenon occurs in themanufacture of optical switches. This technique for the growth of true epitaxial structurescreates a minimum number of defects allowing for lower operating costs and higher rates ofproduction.

CHM-1075 Seedless copper electroplating for Damascene processCopper interconnects for silicon chips are created in a process called Damascene. To preventsilicon degradation due to interaction with the copper, a barrier layer of tantalum is requiredto separate the two. Before electroplating is utilized to fill the channel with copper, a seedlayer of copper needs to be deposited using PVD methods. Modern integrated circuits aredesigned with ever smaller channel lengths. Channel lengths of 32 nm and less pose achallenge to the current Damascene process as copper seeding via PVD creates a copperoverhang on each side of the channel, sometimes blocking it altogether. Subsequent copperelectroplating then results with faulty interconnects. The invention provides a thorough,tested solution of an electrochemical nature to this problem, which integrates seamlessly withcurrent equipment utilized in the Damascene process.

CHM-1153 Low-power vertical organic FET for low-cost large-area electronicsAdvantaged with low-cost and large-area fabrication, flexible and unconventional substratesamenability, Organic Field Effect Transistors (OFETs) are expected to be integrated in a varietyof applications, including RFID tags, flexible active matrix displays, and bio-compatible sensorsarrays. Yet the inherent low mobility of Organic Semiconductors (OSCs) dictates highoperating voltage and high power consumption – both scarce in typical off-grid applications.This invention provides devices based on novel patterned-electrode Vertical OFET architecture.Based on self-assembly processes, low-cost, high performance, and low-power organicswitching, devices that can deliver high current densities are achieved.




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CHM-1407 Method for reversible and bistable switching of current in Electron Field EmissionInnovative memory switch devices require reliable bistable conductance properties. It wouldbe desirable if such bistable characteristics were available in robust solid state materials suchas diamond, benefiting from outstanding physical properties. Here we report on a bistablecurrent with reversible switching effect from surface transfer doped ultrananocrystallinediamond thin films measured by electron field emission. This switching is manifested by theappearance of huge jumps in the current emission, up to 4 orders of magnitude, occurring atspecific extracting electric field values. Persistent hysteresis is exhibited whenever the field isramped down. We propose that these phenomena are the result of resonant-tunnelingthrough a double barrier junction composed of ta-C / Nano Diamond / adsorbent / vacuum.This finding shows the first electron source material having ultrafast switching with memoryeffect; this may use for the realization of novel kinds of memory switch devices withunprecedented performance or electron sources with high resolution and fast response.

COM-0731 Gate diffusion inputs (GDI) circuit designOur gate diffusion inputs (GDI) technology is superior when dealing with the rising challengesof digital circuits design. Current methods are based on standard logical gates and are notcompatible with the increasing demands for low power designs in the electronics industry.Our technology is simple to implement, cost effective and based on multi-functionalbuilding blocks.

COM-0894 Improved transistor structuresField Effect Transistors (FETs) are devices in which an electric field created by a gate controlsthe flow of current along the transistor's channel from the source to the drain. Thin FilmTransistors (TFTs) are a form of this device which can be used as a back-plane for non-emissive displays, like LCDs or electronic ink displays, or for emissive displays based on OLEDsor even for logic circuits. Unfortunately, most low cost TFTs (organic or amorphous silicon) arerestricted in the amount of current they can provide which increases the switching time andenhances background noise – all undesirable effects for a transistor. This technologyeffectively shorts the channel enhancing its conductivity without doping it in any way. All ofthe potential problems associated with doping such as ion diffusion and charge diffusion areabsent offering a thin film transistor with enhanced performance that is able to provide morecurrent than conventional TFTs, reduced switching times and reduced background noise.

COM-0910 Deep nanopatterning FIB technologyFocused ion beam (FIB) technology is widely used in the semiconductor industry. FIB etchingis used to develop and modify optoelectronic and microelectronic devices. However, FIBtechnology is limited to large scale devices and is incompatible with the industry trend toreduce device dimensions. Our technology is unique and enables nanometric scale FIBlithography.


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CHM-0708 Negative fullerene ion beams generation - method and apparatusSee ‘Nanotechnology’, page 49

COM-0945 LED-like photon pair sourceSee ‘Optics and Lasers’, page 54

COM-0987 BENoC - Bus enhancement NoCSee ‘Networks and Communication’, page 51

COM-1050 Optical logic gateSee ‘Optics and Lasers’, page 54


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Signal, Audio and Image Processing

COM-0751 Automatic re-meshing from a 2D grid to a 3D model ofgenus-n based on topological analysisThis technology is a method for re-meshing complex 3D bodies with holes which are typicalof CAD/CAM and computer analysis systems in the engineering and medical fields. Thismethod is qualitatively different than other re-meshing methods and offers an efficientsolution based on a new approach utilizing topographical knowledge of the body. It alsoallows for great flexibility in changing the parameters of the meshing (shape of elements,density, adaptability, etc.)

COM-0805 Image de-hazingImaging in poor atmospheric conditions suffers from reduced contrast and object visibility.Image processing methods can recover these qualities by analyzing the medium polarizationand background component. Current methods require complex analysis, and some methodsneed the presence of the sky in the image. These limitations impose conditions on theimaging medium that are not always feasible. Our technology is simpler and does not requirethe presence of sky in the image.

COM-0819 Hidden point removalThree-dimensional scanners create a point cloud after scanning an object. When viewing thepoint cloud of the scanned object it is helpful, and sometimes necessary, to remove pointsthat would be hidden if the object were solid. This innovative technique for removing hiddenpoints is beneficial for a variety of applications, such as fast and simple view-dependentsurface reconstruction and shadow casting. This technique can be utilized for medicalapplications, geometric modeling, computer games, military applications, security, andarchitecture design.

COM-0834 Recovering object visibility and structure in a scattering mediumwhen using artificial illuminationThere is a wide spectrum of uses for images taken in scattering media such as fog, water andeven in biological tissue. Unfortunately, these images suffer from poor visibility due tobackscattering and signal attenuation. Backscatter is especially strong when using artificialillumination. This technological approach which is instant, simple, easy to build and low-costresults in a computational visibility improvement which has already been demonstratedunderwater in poor visibility conditions. It also yields a rough estimate of the 3D scenestructure and may even be extended to work with multiple illumination sources.


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COM-0914 Robust silhouette tracking in video streamsVideo films in various applications can track non-rigid objects using camera's visual trackers.Most trackers rely on a common model, which operates under limited conditions, andtherefore fails to achieve the needed speed and robustness for flexible tracking. Thanks to aninnovative approach, our novel algorithm enables greater flexibility to the motion analysisprocess so higher accuracy is achieved.

COM-0948 Efficient real-time acquisition of textured 3D videoReproducing a live scene–such as a football game–with 3D cameras is far from being feasible.When filming in 3D, the camera's view is often obstructed by objects in the scene. For thisreason multiple cameras are needed in order to capture the entire scene, which can result inunreasonable costs. Our algorithm enables the substitution of some of the 3D cameras withordinary video cameras, and is suited for real-time operation.

COM-1009 Asynchronous multi-band signal samplingMulti-bands signals are efficient for information transfer but sampling and reconstruction ofsuch signals is a growing challenge due to increasing carrier frequency in communicationsystems. Existing methods for processing such signals requires expensive hardwareimplementation and is dependent on signal characteristics. Our technology is a low-costsolution to these limitations.

COM-1071 Texture and image interpolation using Markov modelsImage upscaling technologies are in demand due to the influx of high-definition displays andthe prevalence of low-resolution content. Our algorithm allows for the restoration of texturedimages out of low-resolution or low-quality ones. The algorithm analyzes the imagestatistically to achieve superior results as compared to simple methods such as bicubic andbilinear. This also enables high-ratio compression for textures and introduces an innovativecriterion for comparison of image textures, which may be used for different applications.

COM-1080 Pinpoint MicrophoneThe intuitive pin-point selection of an individual within a crowd to detect their voice hasseveral important applications from highly directional hearing aids to eavesdropping on, oridentifying a suspect in public. This invention detects sound at a distance with the requiredsub-nanometer sensitivity, surmounting the inherent difficulties of optical detection ofreflections from scattering surfaces, unstable detection geometries, environmentaldisturbances and background interference.




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COM-1103 Complex barycentric coordinatesBarycentric coordinates are heavily used in computer graphics applications to generalize a setof given data values. Traditionally, the coordinates are required to be real and positive. Werelax this requirement by allowing the barycentric coordinates to be complex numbers whichlead to several powerful advantages. These new coordinates are highly effective in generatingconformal mappings from a given planar source region to a planar target region. Complexbarycentric coordinates can be used for image manipulation, shape deformation, animation,data interpolation, color interpolation and parameterization.

COM-1117 Texture mapping of 3D models using casual imagesTexture mapping from 2D images is a method for adding detail, surface texture or color to acomputer-generated graphic or three-dimensional model, commonly used in computergraphics, computer games, virtual worlds etc. In the known solutions to the problem, when acasual image is used, high distortions in the texturing occur. Our technology avoids suchdistortions by formulating the mapping as a camera projection matrix.

COM-1119 Method for Images Saliency DetectionThe novelties in automatic creation of digital albums, digital cameras and digital imageediting tools assisted in developing advanced image based applications. Nevertheless, Theseproducts produce shape images that are often aesthetically unsatisfactory, partly due to theirfailure to extract the interesting part of an image, and partly due to their limitations inextracting only rectangular regions. Our technology is significantly better at recognizing,defining and extracting regions of interest (ROIs) from image and can be applied in a widevariety of applications.

COM-1154 Photonic-enabled ultra-high-speed RF analog-to-digital conversionDigital Signal Processing (DSP) has revolutionized modern communications and radarsystems and is an integral part of many other industries. For broadband systems, theapplication of DSP systems is hindered by the difficulty in capturing (digitizing) thewideband signal in real time. Although Wideband Analog-to-Digital Converters (ADC) arein high demand, a satisfactory solution doesn’t exist yet in the market. This technologyutilizes a number of innovation to create systems that easily outperform existing solutions.

COM-1194 Speckle-Noise elimination in holographic projectionThe demand for three-dimensional images in popular entertainment and information systemsis growing quickly. Speckle noise is a major disturbance in phase-only holographic projectionsbut current solutions for the removal of this interference have many drawbacks. They eitherfail to remove the interference completely or require a significantly more complex calculationmethod demanding more computing resources reducing the possible rate of projection andincreasing the size of the holographic unit. Our method completely removes the specklenoise without excessive computation or additional optical components allowing forunadulterated high-rate holographic projections.


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COM-1304 Blackbody as a THz emitter and a THz measurement andcharacterization set-up based on blackbody and THz filtersTHz radiation bridges the gap between mm-waves and mid/far IR. Until recently, this spectralrange has received limited attention due to the lack of efficient and low/moderate cost THzsources and detectors. However, there are a number of promising applications such as THzimaging (concealed weapon and explosive detection) and THz spectroscopy (pharmaceutical,biomedical, and materials inspection applications). Successful exploitation of the potential ofTHz technology requires the availability of low cost, versatile and powerful THz emitters aswell as highly sensitive, un-cooled and small detectors. This invention uses a blackbodyapparatus to enable the manufacture of relatively low-cost THz systems to meet these needs.

COM-1348 A new voltage controlled oscillator (VCO) topology formm-wave integrated circuitsVoltage controlled oscillators are a critical part of frequency synthesizers and are used togenerate a reference frequency for a wide range of systems such as radio transceivers, mobiletelephones, satellite communications, GPS systems, etc. Frequency synthesis at mm-wavefrequencies is challenging due to the low performance of the transistors and their high DCpower consumption. Due the inability to generate sufficient signal power, the output of thevoltage controlled oscilator (VCO) is not connected directly to the load and thereforebuffers/amplifiers are used. The technology presented here offers a much more compact andpower efficient topology for mm-wave VCO by employing the concept of a quasi phase-shiftoscillator that provides a superior output power to the load. In addition, it's unique topologyeliminates the need for buffers or amplifiers at the output. All apllications around thefrequency of 20 GHz and higher can benefit from this new design including commercial,military and scientific applications ranging from consumer electronics, satellitecommunications, radar, sensing and imaging.

COM-1365 A boost method for reconstruction algorithms in computed tomography,based on machine learningComputed Tomography (CT) has become a very important tool in medical imaging and isused for preventive medicine or disease screening. CT images are produced by reconstructionalgorithms that depend heavily on different parameter values that lead to images of differentresolutions and noise levels and therefore different important information. The proposedinvention is a generic method for performance boosting of the various algorithms in order topresent to the radiologists a single image that incorporates the advantages of the individualreconstruction methods and simultaneously enables a reduction in radiation dose. Due to thealgorithm’s generic method it is also applicable to general inverse problems.



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CTT-0838 Super resolution with no explicit motion estimationMany videos have unsatisfactory optical resolution. Improving the resolution requires recoveryof sub-pixel details. Our method is a novel and successful super resolution algorithm, whichdoes not rely on explicit motion estimation. Instead, a local and patch-based approach iscombined with fuzzy motion estimation. Possible applications include digitalcameras/camcorders, TV sets, video projectors, video editing software, video display software,media centers, video conference software, and security systems.


COM-1342 Supply Chain SimulatorManagement of supply chains is a major issue in operations, and teaching supply chainmanagement and supporting decisions in this area is a real need for many businesses as wellas academic institutions. However, no analytical model can express the true richness of anyreal world supply chain problem. Available models either have a very limited range ofscenarios or are so all-inclusive that they lose the focus on supply chains. We have designedsoftware that enables simulating complicated supply chain models and can interface withexisting software as well as generate scenarios based on real supply chains stored in thesystem. The simulation allows students on the one hand, and business users (like inventorymanagers) on the other hand to gain a deeper understanding of how supply chains work.

COM-0712 GeomCore - outstanding 3D graphicsGeomCore offers a whole framework that allows three-dimensional geometry to bepresented over the World Wide Web. The geometry is presented in an efficient way andallows for a high degree of interaction and collaboration, all in real time. GeomCore’stechnology can serve as the basis for numerous applications such as MCAD 3D visualizationover the Web, 3D icons and collaborative 3D games.

COM-0921 Optimal measurement technique of variable arraysMultiple-source illumination methods have numerous advantages in the field of computervision and image processing. Optimization of all available light sources is a challenge to theproduction of a superior image. Current methods ignore the inherent difficulties in multiple-source schemes and are in most cases counter-productive. Our effective technology addressesthe difficulties of image optimization and can also be applied outside these fields.

COM-0992 PIXSAR: Disk reclustering for faster XML databasesPIXSAR is an algorithm that is capable of efficiently rearranging an XML-based database. Itdoes so by treating database clustering as an augmented tree partitioning problem andadjusting the data physical layout according to the dynamic workload. iPIXSAR, an extension,is able to do so in the presence of multiple-indexes over the database.


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COM-1030 Efficient and general Voronoi diagrams algorithmVoronoi diagrams are a powerful computational tool. They appear in many areas in scienceand technology, and have diverse applications. One can find the diagrams and theirapplications in chemistry, computer science, geography, economics, communication, art,materials engineering and more. Our algorithm is simple and efficient, and significantlyimproves current calculation capabilities of existing algorithms. For example, it can computeVoronoi diagrams of general sites in general normed spaces (of any dimension), in manifoldsand in other settings. In addition, it supports parallel computing.

COM-1035 Decision support tool for project managementDespite the common use of project management software, many projects still fail to meettheir goals on time and within budget. This is partly because these tools do not allow theproject team to actively experiment with "what-if" scenarios during the course of the project.Our technology allows for the interactive simulation of stochastic events on real-worldprojects, enabling the management team or students to discuss, analyze and find moreoptiomal solutions while developing better judgment.

COM-1104 TCAM with fast error detectionTernary Content-Addressable Memory (TCAM) devices are increasingly being used forperforming high-speed classification of data packets required by networking applicationssuch as routing, monitoring and security. The parallel-access properties of TCAM devicesmake them prone to errors which standard error detection schemes are not designed tohandle. Our technology is a parallel error detection scheme which is optimized for TCAM. Itallows an order of magnitude reduction in the number of lookups required for the errorlocation process, thereby increasing performance and reliability.

COM-1163 Optimal inspection of multidimensional regionsSecuring a complex terrain or mold designs are examples of seemingly unrelated geometricproblems that deal with region /object coverage Our novel algorithm can compute an(almost) optimal solution to the complete coverage of multidimensional region. Thealgorithm has two major stages. In the first, visibility is determined from a set of positions. Inthe second, an approximation to the set-cover problem is computed.

COM-1282 Mitigation of Inter-Cell Coupling Effects in NAND Flash MemoryNAND flash memory is a popular data storage facility at various electronic devices. However,it suffers from an inter-cell coupling effect which reduces the memory functionality. Aninnovative method improves the NAND flash memory operations by diminish the inter-cellcoupling effect.

COM-1394 Aquatic event detection algorithmSee “Water,” page 15



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COM-0812 Monitoring multi-variate threshold functions over distributed data streamsSee ‘Web Sites and Web Technologies’ below

COM-1103 Complex barycentric coordinatesSee ‘Signal, Audio and Image Processing’, Page 67

COM-1150 Monitoring threshold functions over multiple nodes in distributed data setsSee ‘Web Sites and Web Technologies’, Page 72


COM-0779 Enriching document representation for information retrieval tasksElectronic information retrieval became an important part of our daily lives. However, not allof the information that exists in electronic databases is efficiently searchable for the averagereader. This novel technology draws on the power of repositories of collective humanknowledge and understanding (e.g. Wikipedia) to assist in retrieving documents moreefficiently. It can also be used to enable answering questions asked in natural language orcarry out categorization and analysis of complex texts.

COM-0812 Monitoring multi-variate threshold functions over distributed data streamsA common requirement in many emerging applications is the ability to process, in real time, acontinuous high-volume stream of data. Consequently, data stream monitoring in adistributed system is the focus of much research in recent years. Examples of suchapplications are sensor networks, real-time analysis of financial data and intrusion detection.We present a novel geometric approach utilizing naive, centralized algorithms for efficientarbitrary threshold functions monitoring over distributed data streams without requiring thevery high communication overhead common in other methods.

COM-0913 Protection of copyrighted material on the webThe internet is increasingly becoming a major source for knowledge and information. Searchengines and other web sites that provide information invest extensive resources to meet theuser’s demands. Currently, these efforts result in limited information or may lead to legaldisputes. Our technology enables a content provider to provide all information withoutviolation of any law.

COM-0944 XPathL – logical language for integrating relational and XML databasesThe joint processing of XML and relational data is of major importance in information andknowledge management. Many database management systems support XML data, which isthe de facto standard for data representation and exchange over the web. Our methodhandles conjunctive queries, comprising relational predicates and external predicates, such asXML predicates. The language can be utilized as a target language for higher level constructsor as an embedded query language.


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COM-1067 Maximizing restorable throughput in MPLS networksMPLS recovery mechanisms algorithms are used by large network operators to assure highQoS in case of failure by pre-establishing backup network paths. Current networks use simplemethods for calculating feasible primary and backup paths. However, these paths may notefficiently use the network resources and may block other traffic from being serviced, therebyreducing profitability. Our highly efficient algorithm allows network operators to maximizetheir revenues by allocating primary and backup paths more efficiently without compromisingQoS.

COM-1094 Advanced query language for social networksAs online social networks become increasingly popular, the amount of available data isconstantly on the rise. Search options for end users, however, have remained limited. Ourquery language opens up new possibilities for retrieving useful data from these vastdatabases. This language enables new features not implemented today due to resourcelimitations, such as retrieving the shortest “acquaintance path” between users undervarious constraints.

COM-1150 Monitoring threshold functions over multiple nodes in distributed data setsVarious systems and applications perform monitoring of data streams in a distributedenvironment. Such applications include, for example, sensor networked, distributed web-sites, etc. Existing methods for data stream monitoring require high computational costswhen monitoring non-linear functions. They are also limited in the number of distributednodes and monitored objects. This method employs a novel geometric approach to monitorthe data stream at much greater efficiency and with many fewer restrictions.

COM-1197 Social networks interaction protocolSocial network interaction protocol is an automated feature involving intelligentcommunication between large numbers of participants in social networks. Known implantedfeatures like allow structured communication regarding events, but they are lack a widerange of communication and dissemination options. We managed to expand social networkcommunication opportunities by creating a new generic protocol that can be modifiedby participants.

COM-1204 Multi-core XML query processingMulti-core XML processing is a method that allows better processing performance of an XMLTwig Pattern query. The known processing method use sequential algorithms that deal with asingle query processing, but since modern computers have multi-core processors wemanaged to optimize the processing performance of a twig pattern XML query byparallelizing two existing sequential algorithms and in this way create new novel andefficient algorithms.

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