Sythesis and the reagents

ISSN 0265-4245 5608256303 January 2005

Graphical abstracts ofnew developments

www.rsc.org/mos

METHODS INORGANIC SYNTHESIS

CONTENTS

Editorial . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2

Angewandte Chemie, International Edition . . . . . . . . . . . . . . . . . 3Chemical Communications . . . . . . . . . . . . . . . . . . . . . . . . 4European Journal of Organic Chemistry . . . . . . . . . . . . . . . . . . 8Helvetica Chimica Acta . . . . . . . . . . . . . . . . . . . . . . . . . . 8Journal of Organic Chemistry . . . . . . . . . . . . . . . . . . . . . . . 8Journal of the American Chemical Society . . . . . . . . . . . . . . . . 10New Journal of Chemistry . . . . . . . . . . . . . . . . . . . . . . . 15Organic & Biomolecular Chemistry . . . . . . . . . . . . . . . . . . . . 15Organic Letters . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15Synthesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23Synthetic Communications . . . . . . . . . . . . . . . . . . . . . . . 27Tetrahedron . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33Tetrahedron Letters . . . . . . . . . . . . . . . . . . . . . . . . . . 35

Books, Reviews and Conference Proceedings . . . . . . . . . . . . . . . 40

Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41Reagent Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43Reaction Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45Reactant Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46Product Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47

Journal Selection . . . . . . . . . . . . . . . . . . . . . . . . . . . 49Abbreviations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50

Royal Society of Chemistry 2005

Editorial

2 METHODS IN ORGANIC SYNTHESIS January 2005

Editorial

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Angewandte Chemie, International Edition


56082 A practical and mild method for the highly selective conversion of terminal alkenes into aldehydesthrough epoxidationisomerization with ruthenium(IV)catalystsJ. Chen, C.-M. Che*, Angew. Chem., Int. Ed., 2004, 43(37), 4950-4954

catalyst

CDCl3, 60 C, 2 h14 examples (8199%) 96%

CHO2,6-dichloropyridine N-oxide,

air

RuCl

Cl

catalyst =

56083 Enantioselective hydrogenation of -ketoesters with monodentate ligandsK. Junge, B. Hagemann, S. Enthaler, G. Oehme, M. Michalik, X. Monsees, T. Riermeier, U. Dingerdissen, M. Beller*, Angew.Chem., Int. Ed., 2004, 43(38), 5066-5069

80 C, H2 (60 bar), 16 h

>99%, 28% ee (S)38 examples (28>99%, 295% ee)

[L2RuBr2]H3C OCH3

O O

H3C OCH3

OH O

OO

P OPhL =

56084 Difluoromethyl phenyl sulfone, a difluoromethylidene equivalent: use in the synthesis of1,1-difluoro-1-alkenesG. K. S. Prakash*, J. Hu, Y. Wang, G. A. Olah, Angew. Chem., Int. Ed., 2004, 43(39), 5203-5206

The alkyl-substituted difluoromethyl sulfones can be synthesized from difluoromethyl phenyl sulfone, theappropriate alkyl iodide and potassium tert-butoxide (13 examples, 3784%)

THF, 20 C rt

87%8 examples (5588%)

tBuOKPhO SO2Ph PhO

56085 Evidence for the formation of an iodosylbenzene(salen)iron(III)-catalyzed asymmetric sulfide oxidationK. P. Bryliakov*, E. P. Talsi, Angew. Chem., Int. Ed., 2004, 43(39), 5228-5230

CH2Cl2, 0 C, 2 h

94% conversion,92% selectivity,

58% ee (S)-()-isomer3 examples (7466% conversion,

catalystPh S

PhPh S

Ph

O

6999% selectivity,2062% ee)

N N

O OFe

Cl

H H

catalyst =

PhIO

56086 Development of a ruthenium-catalyzed asymmetric epoxidation procedure with hydrogen peroxide asthe oxidantM. K. Tse, C. Dobler, S. Bhor, M. Klawonn, W. Magerlein, H. Hugl, M. Beller*, Angew. Chem., Int. Ed., 2004, 43(39), 5255-5260

tBuOH, rt, 12 h

12 examples (59100% yield, 72100% selectivity, 2884% ee)

30% aq. H2O2Ph Ph

Ocatalyst

93% yield93% selectivity

80% ee

catalyst =

NO

N N

O

Ru

NO

O

O

O

METHODS IN ORGANIC SYNTHESIS January 2005 3


56087 Gold(I)-catalyzed 5-endo-dig carbocyclization of acetylenic dicarbonyl compoundsS. T. Staben, J. J. Kennedy-Smith, F. D. Toste*, Angew. Chem., Int. Ed., 2004, 43(40), 5350-5352

CH2Cl2, rt, 5 min

83%12 examples (7499%)

[Au(PPh3)]Cl, AgOTfOMe

O O

MeO

O

O

56088 Ru- and Rh-catalyzed CC bond cleavage of cyclobutanones: reconstructive and selective synthesis of2-pyranones, cyclopentenes, and cyclohexenonesT. Kondo, Y. Taguchi, Y. Kaneko, M. Niimi, T. Mitsudo*, Angew. Chem., Int. Ed., 2004, 43(40), 5369-5372

toluene, 100 C, 2 h

86%4 examples (7586%)

[RhCl(CO)2]2 or [RuCl2(CO)3]2O O

O

56089 Carboamination: additions of imine C1N bonds across alkynes catalyzed by imidozirconium complexesR. T. Ruck, R. L. Zuckermann, S. W. Krska, R. G. Bergmann*, Angew. Chem., Int. Ed., 2004, 43(40), 5372-5374

C6D6, 145 C, 3096 h80%7 examples (5885%)

NNCp2Zr N

Ph Ph

OMe

O

Ph

O

Ph

PhPh

56090 Zirconium-mediated conversion of amides to nitriles: a surprising additive effectR. T. Ruck, R. G. Bergmann*, Angew. Chem., Int. Ed., 2004, 43(40), 5375-5377

[D8]THF, 105 C, 48 h8 examples (91100%)

Cp2ZrMe2NH2

O

96%

LiClCN

56091 Electrophilic alkylations in neutral aqueous or alcoholic solutionsM. Hoffmann, N. Hampel, T. Kanzian, H. Mayr*, Angew. Chem., Int. Ed., 2004, 43(40), 5402-5405

CF3CH2OH, rt

70%19 examples (33100%)

2,6-lutidineCl

MeO MeO

OO

Chemical Communications

56092 Direct arylation of aromatic CH bonds catalyzed by Cp*Ir complexesK.-i. Fujita*, M. Nonogawa, R. Yamaguchi*, Chem. Commun., 2004, (17), 1926-1927

[5-C5Me5IrHCl]2KOtBu, 80 C, 30 h

9 examples (3272%) 70%

I



56093 First catalytic asymmetric synthesis of -amino--polyfluoroalkyl ketones via proline-catalysed directasymmetric carboncarbon bond formation reaction of polyfluoroalkylated aldiminesK. Funabiki*, M. Nagamori, S. Goushi, M. Matsui, Chem. Commun., 2004, (17), 1928-1929

L-prolineacetone, rt, 7 d

19 examples (ee 20.498.0%) 98% ee, 71% yield, 99 : 1 = S : RC6H4OMe-p

O

F2HC

NH Op-MeOC6H4F

F

56094 A highly efficient gold/silver-catalyzed addition of arenes to iminesY. Luo, C.-J. Li*, Chem. Commun., 2004, (17), 1930-1931

CH2Cl2, 0 C, 12 h

9 examples (3485%) 85%

AuCl3AgOTf

OMe

MeO OMeEtO2CHC NTs

OMe

MeO OMe

CO2Et

NHTs

56095 CuI-catalyzed coupling reaction of aryl halides with terminal alkynes in the absence of palladium andphosphineD. Ma*, F. Liu, Chem. Commun., 2004, (17), 1934-1935

CuIN,N-dimethylglycineK2CO3, DMF, 100 C, 24 h

26 examples (6098%) 98%

H3-NO2C6H4I 3-NO2C6H4Ph Ph

56096 Radical addition of nitrones to acrylates mediated by SmI2: asymmetric synthesis of -amino acidsemploying carbohydrate-based chiral auxiliariesS. A. Johannesen, S. Albu, R. G. Hazell, T. Skrydstrup*, Chem. Commun., 2004, (17), 1962-1963

THF, 78 C, 20 h

9 examples (5480%) 71%, >95 : 5 ds

SmI2O

Cy

N O

OO

O

OnBuO

Cy

N HO

OO

O

OnBu

56097 (Bu3Sn)2TBAF: a new combination reagent for the reduction and deuteration of aryl bromides and iodidesD. C. Harrowven*, I. L. Guy, M. I. T. Nunn, Chem. Commun., 2004, (17), 1966-1967

(Bu3Sn)2TBAFPhMe, 90 C, 1 h

13 examples (9099%) 97%

O

O

HSS

Br

O

O

HSS

56098 Palladium catalysed cross-coupling reactions of silylaminesC. J. Smith*, T. R. Early, A. B. Holmes*, R. E. Shute, Chem. Commun., 2004, (17), 1976-1977

Pd(OAc)2,P(t-Bu)2(o-biphen)Sc2Co3, scCO2,

100 C, 17 h

18 examples (2584%) 84%

CO2Me

NTMS

CO2Me

Br

MeO2C CO2Me

N



56099 A highly efficient heterogeneous catalytic system for Heck reactions with a palladium colloid layerreduced in situ in the channel of mesoporous silica materialsL. Li, J.-l. Shi*, J.-n. Yan, Chem. Commun., 2004, (17), 1990-1991

NEt3, 120 C, 50 min

8 examples (conversion 37100%, yield 8599%) 100% conversion, 99% yield

Pd-SBABr COMe

PhMeOC

Ph

56100 Highly efficient and recyclable heterogeneous asymmetric transfer hydrogenation of ketones in waterP. N. Liu, J. G. Deng, Y. Q. Tu*, S. H. Wang, Chem. Commun., 2004, (18), 2070-2071

[RuCl2(p-cymene)]2silica gelBu4NBr, HCO2Na, 311 h

11 substrate examples (ee 90>99%) >99% conversion, 94% eeCl

O

Cl

OH

56101 First example of ring expansion of activated quinolines and isoquinolines: novel benzoazepinesJ. S. Yadav*, B. V. Subba Reddy, M. K. Gupta, A. Prabhakar, B. Jagadeesh, Chem. Commun., 2004, (18), 2124-2125

1,2-dichloroethane,reflux, 0.5 h

11 examples (8098%) 98%

Cu(OTf)2N O

O

Cl

N2 CHCOPh N

COPh

O

O

56102 Practical highly enantioselective synthesis of terminal propargylamines. An expeditious synthesisof (S)-(+)-coniineN. Gommermann, P. Knochel*, Chem. Commun., 2004, (20), 2324-2325

(i) CuBr, (R)-Quinaptoluene, rt, 3 d

(ii) TBAF

15 examples (7297% yield, 8498% ee) 84% yield, 98% ee

i-PrH

NBn2

i-PrCHO H SiMe3 HNBn2

(R)-Quinap =

N

PPh2

56103 First asymmetric SmI2-induced cross-coupling of Cr(CO)3 aromatic nitrone complexes with carbonylcompoundsM. Chavarot, M. Rivard, F. Rose-Munch*, E. Rose, S. Py, Chem. Commun., 2004, (20), 2330-2331

THF, 78 C, 30 min

6 examples (yield 6596%, dr >95 : 5) 96% yield, >95 : 5 dr

SmI2

Me

Cr(CO)3

NH

BnO

But H

O

Me

Cr(CO)3

NOH

Bn tBu

OHH

56104 An active ferrocenyl triarylphosphine for palladium-catalyzed SuzukiMiyaura cross-coupling of arylhalidesF. Y. Kwong*, K. S. Chan, C. H. Yeung, A. S. C. Chan*, Chem. Commun., 2004, (20), 2336-2337

Pd2(dba)3, LKF, THF, N2, rt, 24 h

17 examples (8398%) 98%MeO Br

OMe

B(OH)2 MeO

OMeL =

PPh2

Fe



56105 A novel strategy for the preparation of arylhydroxylamines: chemoselective reduction of aromatic nitrocompounds using bakers yeastF. Li, J. Cui*, X. Qian*, R. Zhang, Chem. Commun., 2004, (20), 2338-2339

baker's yeastphosphate buffer, glucose,

30 C, 1 h

10 examples (conversion 86100%,c : d = 70 : 30 to >98 : 2)

conversion 99%

NO2

CNCN CN

CN

NHOH NH2

CNCN

c>98

d2

::

56106 Polysulfones: solid organic catalysts for the chemoselective cleavage of methyl-substituted allyl ethersunder neutral conditionsD. Markovic, P. Steunenberg, M. Ekstrand, P. Vogel*, Chem. Commun., 2004, (21), 2444-2445

cyclohexane, 80 C

85%12 substrates (8596%)

OHOHO

OCH2C(Me)=CH2

OO

OHOHO

OH

OO

SO2 SO2Na

n

56107 BINOL catalyzed enatioselective addition of titanium phenylacetylide to aromatic ketonesP. G. Cozzi*, S. Alesi, Chem. Commun., 2004, (21), 2448-2449

BuLi, ClTi(OiPr)3, 30 C, 24 h

70%, 89% ee8 ketone substrates (2898%, 2890% ee)

(R,R)-BINOLPh

O

+HO

Ph

56108 L-Proline catalyzed asymmetric transfer aldol reaction between diacetone alcohol and aldehydesS. Chandrasekhar*, C. Narsihmulu, N. R. Reddy, S. S. Sultana, Chem. Commun., 2004, (21), 2450-2451

DMSO, rt, 4 h

86%, 71% ee10 substrates (4091%, 4896% ee)

L-ProlineH

O

+

O2N

diacetone alcohol

NO2

O OH

56109 The first tandem double palladium-catalyzed aminations: synthesis of dipyrido[1,2-a:3,2-d]imidazole andits benzo- and aza-analoguesK. T. J. Loones, B. U. W. Maes*, R. A. Dommisse, G. L. F. Lemiere, Chem. Commun., 2004, (21), 2466-2467

CsCO3, toluene, reflux, 17 h


Pd(OAc)2, BINAP or XANTPHOS+

NN

I

Cl NH2 NN

N

56110 Aziridine sulfides and disulfides as catalysts for the enantioselective addition of diethylzinc to aldehydesA. L. Braga*, P. Milani, M. W. Paixao, G. Zeni, O. E. D. Rodrigues, E. F. Alves, Chem. Commun., 2004, (21), 2488-2489

Toluene, rt, 24 h

82%, 87% ee (S)5 catalysts (4282%, 37>99% ee)

+H

O

Et2Zn

OHSN

Ar

2



56111 Enantioselective synthesis of allenyl carbinols by the CBS reduction in nitroethane: dramatic solventeffect for reactivity and enantioselectivityC.-M. Yu*, C. Kim, J.-H. Kweon, Chem. Commun., 2004, (21), 2494-2495

Catecholborane, 78 C, 1 h, CH3CH2NO

93%, 93% ee6 substrates (8695%, 92>99% ee)

O

PhH2CH2CMe

HO

PhH2CH2CMe

HN B

O

Me

Ph Ph

European Journal of Organic Chemistry

56112 Copper-catalyzed synthesis of N-unsubstituted 1,2,3-triazoles from nonactivated terminal alkynesT. Jin, S. Kamijo, Y. Yamamoto*, Eur. J. Org. Chem., 2004, (18), 3789-3791

DMFMeOH, 100 C, 12 h

83%12 alkynes (5595%)

CuIH + TMSN3

NN

NH

H

Helvetica Chimica Acta

56113 Chrial borate esters in asymmetric synthesis Part 2 Asymmetric borane reduction of prochiral ketones inthe presence of a chiral spiroborate esterD. Liu, Z. Shan*, Y. Zhou, Z. Wu, J. Qin, Helv. Chim. Acta, 2004, 87(9), 2310-2317

THF, 05 C, 2 h98%, 92% ee7 substrates (692% ee)

O OH

+ BH3THF

O

OB

O O

HN

56114 Versatile one-step one-pot direct aldol condensation promoted by MgI2H.-X. Wei*, K. Li, Q. Zhang, R. L. Jasoni, J. Hu, P. W. Pare*, Helv. Chim. Acta, 2004, 87(9), 2354-2358

CH2Cl2, rt, 30 min

98%12 examples (6098%)

O O

+ H

O OHMgI2, EtN(iPr)2

Journal of Organic Chemistry

56115 Highly regio- and stereoselective synthesis of polysubstituted cyclopropane compounds via thePd(0)-catalyzed couplingcyclization reaction of 2-(2,3-allenyl)malonates with organic halidesS. Ma*, N. Jiao, Q. Yang, Z. Zheng, J. Org. Chem., 2004, 69(19), 6463-6477

n-Bu4NBr, CH3CN, 16 h

93%, cis:trans 6:9415 examples (4998%)

Pd(PPh3)4+ PhI

n-C6H13CO2Me

CO2Me

Ph

MeO2C CO2Me

C6H13

Me



56116 A facile synthesis of C2,N3-disubstituted-4-quinazoloneS. Xue*, J. McKenna*, W.-C. Shieh, O. Repic, J. Org. Chem., 2004, 69(19), 6474-6477

CH3CN,70 C

95%24 examples (8798%)

PCl3+

O

O

OH

O

NH

OO

O

Cl

NH2

O

O

N

O

NO

O

Cl

56117 Formation of a quaternary carbon center throught the Pd(0)/PhCOOH-catalyzed allylation of cyclic -ketoesters and 1,3-diketones with alkynesN. T. Patil, Y. Yamamoto*, J. Org. Chem., 2004, 69(19), 6478-6481

Toluene

98%14 examples (5198%)

Pd(0)/PhCOOH+

O

OEt

OCl

O OOEt

Cl

56118 Unexpected formation of tetrasubstituted 2,3-dihydrofurans from the reactions of -ketopolyfluoroalkanesulfones with aldehydesC. Xing, S. Zhu*, J. Org. Chem., 2004, 69(19), 6486-6488

Toluene, reflux, 1 hr

90%23 examples (7295%)

Piperidine+Cl(F2C)4O2S Ph

O

Br

O

H

O Ph

SO2(CF2)4Cl

O

Ph

Br

56119 Solvent free amination reactions of aryl bromides at room temperature catalyzed by a (-allyl)palladiumcomplex bearing a diphosphinidenecyclobutene ligandA. S. Gajare, K. Toyota, M. Yoshifuji*, F. Ozawa, J. Org. Chem., 2004, 69(19), 6504-6506

rt, 12 h

98%21 examples (6098%)

tBuOK, [Pd]+Ph Br Ph NH2 Ph

HN Ph

Ph

Ph

P

P

Mes*

Mes*

Pd

+ OTf-

[Pd] =

56120 Enantioselective cyanation/Brook rearrangement/C-acylation reactions of acylsilanes catalyzed by chiralmetal alkoxidesD. A. Nicewicz, C. M. Yates, J. S. Johnson*, J. Org. Chem., 2004, 69(20), 6548-6555

toluene, 45 C, 72 h

catalystcatalyst =


SiEt3

O

NC OBn

O

F

CO2Bn

F

NC OSiEt3

NNAl

OO ClClOiPr

56121 Arylboronic acids and arylpinacolboronate esters in Suzuki coupling reactions involving indoles. Partnerrole swapping and heterocycle protectionM. Prieto, E. Zurita, E. Rosa, L. Munoz, P. Lloyd-Williams*, E. Giralt*, J. Org. Chem., 2004, 69(20), 6812-6820

tolueneEtOHH2O, reflux

Pd(PPh3)4

34 examples (up to 99%) 85%NH

BrMeO

B(OH)2NH

MeO

Na2CO3



56122 Base-catalyzed endo-mode cyclization of allenes: easy preparation of five- to nine-membered oxacyclesC. Mukai*, M. Ohta, H. Yamashita, S. Kitagaki, J. Org. Chem., 2004, 69(20), 6867-6873

tBuOH, 30 C

tBuOK

7 examples (7198%) 94%HO

OTBDMS

OH

PO

OEtOEt

OPOEt

OEt

O

2. PPTS

1. (EtO)2PCl, Et3N

56123 Alkyl- or arylthiolation of aryl iodide via cleavage of the SS bond of disulfide compound by nickelcatalyst and zincN. Taniguchi*, J. Org. Chem., 2004, 69(20), 6904-6906

DMF, 100 C, 48 h

NiBr2-bpy, Zn

16 examples (6192%) 76%

I

SS

S

56124 The first conversion of primary alkyl halides to nitroalkanes under aqueous mediumR. Ballini*, L. Barboni, G. Carlo, J. Org. Chem., 2004, 69(20), 6907-6908

H2O, rt, 1 hAgNO2

13 examples (5390%) 83%I NO2

56125 Reactions on a solid surface. A simple, economical and efficient FriedelCrafts acylation reaction overzinc oxide (ZnO) as a new catalystM. H. Sarvari, H. Sharghi*, J. Org. Chem., 2004, 69(20), 6953-6956

The ZnO could be reused 3 times with little loss in activity

no solvent, rt, 10 minZnO

14 examples (5098%) 94%O

Cl Ph

O OPh

O

Journal of the American Chemical Society

56126 Bifunctional nanocrystalline MgO for chiral epoxy ketones via ClaisenSchmidt condensationasymmetricepoxidation reactionsB. Choudary*, M. Kantam, K. Ranganath, K. Mahendar, B. Sreedhar, J. Am. Chem. Soc., 2004, 126(11), 3396-3397

i) toluene, 100 Cii) TBHP, 25 C

10 examples(070% yield098% ee)

70% yield90% ee

NAP-MgOO

+

O

CH3Ph HPh Ph Ph

OO

56127 PtCl2-catalyzed cycloisomerizations of allenynesN. Cadran, K. Cariou, G. Herve, C. Aubert, L. Fensterbank, M. Malcria*, J. Marco-Contelles, J. Am. Chem. Soc., 2004,126(11), 3408-3409

PhMe, rt, 2448 h

12 examples(3290% yield)

75% yield

(5 mol%) PtCl2

H

MeO

MeOCH3

CH3H

HH

MeO

MeO



56128 Synthesis of medium ring nitrogen heterocycles via a tandem copper-catalyzed CN bondformationring-expansion processA. Klapars, S. Parris, K. Anderson, S. Buchwald*, J. Am. Chem. Soc., 2004, 126(11), 3529-3533

N,N-dimethylethylenediamine, K2CO3; PhMe, 110 C, 2224 h


92% yield

(5 mol%) CuI+

NH2

INH

O

NH

HN

O

56129 Bronsted acid-promoted cyclizations of siloxyalkynes with arenes and alkynesL. Zhang, S. A. Kozmin*, J. Am. Chem. Soc., 2004, 126(33), 10204-10205

CH2Cl2, 20 C

92%11 examples (7699%)

HNTf2

OTIPS OTIPS

56130 Catalytic deallylation of allyl- and diallylmalonatesD. Necas, M. Tursky, M. Kotora*, J. Am. Chem. Soc., 2004, 126(33), 10222-10223

H+

99%16 examples (6899%)

EtAl3, NiBr2(PPh3)2EtOOC PhEtOOC

EtOOCPh

EtOOC

56131 Catalytic cross-coupling of alkylzinc halides with -chloroketonesC. F. Malosh, J. M. Ready*, J. Am. Chem. Soc., 2004, 126(33), 10240-10241

THFEt2O

95%22 examples (7096%)

Cu(acac)2, ZnCl2O

Cl+ iPrMgCl

OiPr

56132 Palladium-catalyzed cyclization/carboalkyation of alkenyl indolesC. Liu, R. A. Widenhoefer*, J. Am. Chem. Soc., 2004, 126(33), 10250-10251

MeOH, rt, 0.5 h

83%15 examples (4592%)

PdCl2(CH3CN)2, CuCl2HN

HN

MeO2C

56133 Ruthenium catalyzed [3 + 2] intramolecular cycloaddition of alk-5-ynylidenecyclopropanes promoted bythe first-generation Grubbs carbene complexF. Lopez, A. Delgado, J. R. Rodriguez, L. Castedo, J. L. Mascarenas*, J. Am. Chem. Soc., 2004, 126(33), 10262-10263

toluene, 110 C, 45 min

78%6 examples (5678%)

EtO2CEtO2C

EtO2CEtO2C

PCy3RuPCy3

Ph

ClCl



56134 Alkylation of alkenes: ethylaluminium sesquichloride-mediated hydro-alkyl additions with alkylchloroformates and di-tert-butylpyrocarbonateU. Biermann, J. O. Metzger*, J. Am. Chem. Soc., 2004, 126(33), 10319-10330

CH2CL2, 15 C, 1 h

82%33 examples (3084%)

Et3Al2Cl3iPr

O Cl

O+

56135 Self-supported heterogenous catalysts for enantioselective hydrogenationX. Wang, K. Ding, J. Am. Chem. Soc., 2004, 126(34), 10524-10525

toluene, H2, 4 atm, 25 C, 10 h

4 examples(>99% conversion89.597.3% ee)

>99% conversion95% ee

(1 mol%) catalystH OCH3

NHAc

O

HCO2CH3

NHAc

catalyst =O

OP

[Rh]N O

OP

NLinker

n

56136 Regio- and chemoselective direct generation of functionalized aromatic aluminium compounds usingaluminium ate baseM. Uchiyama*, H. Naka, Y. Matsumoto, T. Ohwada, J. Am. Chem. Soc., 2004, 126(34), 10526-10527

ii) I213 examples

(40100% yield) 99% yield

i) iBu3Al(TMP)L, THF, 78 Crt, 112 h

OMe OMeI

56137 Nickel-catalyzed intermolecular [3 + 2 + 2] cocyclization of ethyl cyclopropylideneacetate and alkynesS. Saito*, M. Masuda, S. Komagawa, J. Am. Chem. Soc., 2004, 126(34), 10540-10541

toluene, Ar, rt, one night9 examples

(2589% yield)

(10 mol%) Ni(cod)2(20 mol%) PPh3

COOEt

+ Ph H

COOEt

Ph

HPh

H

56138 Intramolecular CN bond addition of amides to alkynes using platinum catalystT. Shimada, I. Nakamura, Y. Yomamoto*, J. Am. Chem. Soc., 2004, 126(34), 10546-10547

anisole, 80100 C, 0.324 h

14 examples(0>99% yield)

(5 mol%) PtCl2+

94% yield

Ph

N Me

O

MeN

Me

PhO

MeN

Me

H

Me

56139 Hydroxyapatite-supported palladium nanoclusters: a highly active heterogenous catalyst for selectiveoxidation of alcohols by use of molecular oxygenK. Mori, T. Hara, T. Mizugaki, K. Ebitani, K. Kaneda*, J. Am. Chem. Soc., 2004, 126(34), 10657-10666

trifluorotoluene, O2 atm, 90 C, 124 h

Numerous examples(8499% conversion

8099% yield)

(0.1 g) PhHAP-0

97% conversion94% yield

O

O

OH O

O

CHO



56140 Cu-catalyzed asymmetric allylic alkylations of aromatic and aliphatic phosphates with alkylzinc reagents.An effective method for enantioselective synthesis of tertiary and quaternary carbonsM. Kacprzynski, A. Hoveyda*, J. Am. Chem. Soc., 2004, 126(34), 10676-10681

Et2Zn, THF, 15 C, N2 atm, 24 h


90% yield91% ee

(10 mol%) chiral Schiff base(5 mol%) (CuOTf)2C6H6OPO(OEt)2H5C6

H5C6

56141 Catalytic isomerization of 1,5-enynes to bicyclo[3.1.0]hexenesM. R. Luzung, J. P. Markham, F. D. Toste*, J. Am. Chem. Soc., 2004, 126(35), 10858-10859

(Ph3P)AuPF6CH2Cl2, rt

10 examples (6199%) 99%

Ph

Ph

H

H

56142 Highly diastereoselective and enantioselective CH functionalization of 1,2-dihydronaphthalenes: acombined CH activation/Cope rearrangement followed by a retro-Cope rearrangementH. M. L. Davies*, Q. Jin, J. Am. Chem. Soc., 2004, 126(35), 10862-10863

2,2-dimethylbutane, 0 C

13 examples(yield 5395%, de >98%, ee 9199%) 95% yield, >98% de, 99.5% ee

Rh2(S-DOSP)4N2

Ph

CO2Me

Ph

HCO2Me

Rh2(S-DOSP)4 =

NSO2Ar

O

O

Rh

Rh

H

4

56143 Bidentate NHC-based chiral ligands for efficient Cu-catalyzed enantioselective allylic alkylations:structure and activity of an air-stable chiral Cu complexA. O. Larsen, W. Leu, C. N. Oberhuber, J. E. Campbell, A. H. Hoveyda*, J. Am. Chem. Soc., 2004, 126(36), 11130-11131

N

Me2Zn, TFH, 15 C, 24 h

>98% conversion, 74% ee15 examples

(4294% yield, 7198% ee)

[Ag], (CuOTf)2.C6H6Ph OPO(OEt)2

H

Ph

HMe

OAg

N

AgO

NN

[Ag] =

56144 Chemoslective silylzincation of functionalized terminal alkynes using dianion-type zincate(SiBNOL-Zn-ate): regiocontrolled synthesis of vinylsilanesS. Nakamura, M. Uchiyama*, T. Ohwada, J. Am. Chem. Soc., 2004, 126(36), 11146-11147

THF, rt, 12 h

100%16 examples (73100%)

[Zn][Zn] =H

PhH

HSi

Ph

MeMe

Me OO

ZnSi

tBu

MeMe

Me

56145 Catalytic enantioselective Michael addition of 1,3-dicarbonyl compounds to nitroalkenes catalyzed bywell-defined chiral Ru amido complexesM. Watanabe, A. Ikagawa, H. Wang, K. Murata, T. Ikariya*, J. Am. Chem. Soc., 2004, 126(36), 11148-11489

Toluene, 20 C, 48 h

99%, 95% ee18 examples (599%, 3098% ee)

[Ru][Ru] =Ph

NO2 + CH2(CO2CH3)2Ph

NO2CH(CO2CH3)2

NH

RuNC6H5

C6H5

SO O



56146 AuCl3-catalyzed synthesis of highly substituted furans from 2-(1-alkynyl)-2-alken-1-onesT. Yao, X. Zhang, R. C. Larock, J. Am. Chem. Soc., 2004, 126(36), 11164-11165

CH2Cl2, rt, 1 h

88%12 examples (5290%)

AuCl3+ MeOH

O Ph OPh

OMe

56147 Zirconium-catalyzed enantioselective [3+2] cycloaddition of hydrazones to olefins leading to opticallyactive pyrazolidine, pyrazoline and 1,3-diamine derivativesY. Yamashita, S. Kobayashi*, J. Am. Chem. Soc., 2004, 126(36), 11279-11282

Toluene, 0 C, 18 h

94%22 examples (6795%, 4298% ee)

Zr(OPr)4, [L]+N

PhH2CH2C H

NH

O C6H4(p-NO2)

OEt HN NC6H4(p-NO2)

O

PhH2CH2C OEt

I I

II

OMe[L] =

56148 Highly enantioselective conjugate addition of nitroalkanes to alkylidenemalonates using efficientphase-transfer catalysis of N-spiro chiral ammonium bromidesT. Ooi, S. Fujioka, K. Maruoka*, J. Am. Chem. Soc., 2004, 126(38), 11790-11791

Toluene, 0 C

99%, 98% ee9 examples (9799%, 8899% ee)

Cs2CO3, [N]Et NO2

CO2iPr

CO2iPrF

CO2iPr

CO2iPrF

EtO2NN

Ar

ArBr

F3C CF3

CF3

CF3

Ar =

+

[N] =

56149 Organocatalytic asymmetric aza-FriedelCrafts alkylation of furanD. Uraguchi, K. Sorimachi, M. Terada*, J. Am. Chem. Soc., 2004, 126(38), 11804-11805

1,2-dichloroethane, 35 C, 24 h95%, 96% ee13 substrates (8496%, 8697% ee) Ar = 3,5-dimesityl phenyl

+OMeO N

p-MeO-C6H4H

BocOMeO

p-MeO-C6H4

NHBoc

Ar

OO

Ar

PO

OH

56150 Gold-catalyzed cycloisomerization of siloxy enynes to cyclohexadienesL. Zhang, S. A. Kozmin*, J. Am. Chem. Soc., 2004, 126(38), 11806-11807

20 C, CH2Cl2


Ph Me

OTIPS

AuCl Ph

TIPSO

Me


Organic Letters

56151 New entries in Lewis acidLewis base bifunctional asymmetric catalyst: catalytic enantioselectiveReissert reaction of pyridine derviativesE. Ichikawa, M. Suzuki, K. Yabu, M. Albert, M. Kanai*, M. Shibasaki*, J. Am. Chem. Soc., 2004, 126(38), 11808-11809

CH2Cl2, 60 C, 27 h

98%, 91% ee7 substrates (8598%, 57>99%)

Et2AlCl, [L]

N

NMe2

O

+ TMSCN + MeOCOCl

N

NMe2

O

NC

OHOH

S

S

O

Ph

O

Ph

[L] =

New Journal of Chemistry

56152 Copper promoted synthesis of diaryl ethersR. Ghosh, A. G. Samuelson*, New J. Chem., 2004, 28(11), 1390-1393

K3PO4, THF, 18 h

33 examples (7>99%) >99%

CuCO3Cu(OH)2H2O

ONa Br

CN

O

CN

Organic & Biomolecular Chemistry

56153 Bromine catalyzed conversion of S-tert-butyl groups into versatile and, for self-assembly processesaccessible, acetyl-protected thiolsA. Blaszczyk, M. Elbing, M. Mayor*, Org. Biomol. Chem., 2004, 2(19), 2722-2724

AcCl/AcOH, rt


Br2Br S Br S

O

56154 The first Cu(I)-mediated nucleophilic trifluoromethylation reactions using (trifluoromethyl)trimethylsilanein ionic liquidsJ. Kim, J. M. Shreeve*, Org. Biomol. Chem., 2004, 2(19), 2728-2734

[IL], 25 C, 3 h

88%8 examples (8898%)

CsF, TMSCF3O

H

OH

HCF3 NOO

O

N(SO2CF3)[IL] =

Organic Letters

56155 Improved procedure for the oxidative cleavage of olefins by OsO4NaIO4W. Yu, Y. Mei, Y. Kang, Z. Hua, Z. Jin*, Org. Lett., 2004, 6(19), 3217-3219

Use of 2,6-lutidine dramatically improved the yield of aldehyde (from 2144% for the same 5 examples)

dioxanewater, 25 C, 20 h

OsO4, NaIO4, 2,6-lutidine

5 examples (7199%) 99%

OO

OTBS

OO

CHO

OTBS


Organic Letters

56156 Titanium catalysis in the Ugi reaction of -amino acids with aromatic aldehydesT. Godet, Y. Bovin, G. Vincent, D. Merle, A. Thozet, M. A. Ciufolini*, Org. Lett., 2004, 6(19), 3281-3284

MeOH, rt, 12 h

TiCl4

16 amino acid and aryl aldehyde examples (7592%, 1.510 : 1 dr) 79%, 5 : 1 dr at *

HOCO2H

NH2

HOMeO2C

NH

CONHtBu

OMeMeOOMeMeO

OHCNtBuC

*

56157 Copper-mediated cross-coupling reactions of N-unsubstituted sulfoximines and aryl halidesG. Y. Cho, P. Remy, J. Jansson, C. Moessner, C. Bolm*, Org. Lett., 2004, 6(19), 3293-3296

DMSO, 90 C

CuI

18 examples (4895%) 72%

IOMe

PhSNH

MeO Cs2CO3 OMe

PhSN

MeO

56158 A highly diastereoselective MgI2-mediated ring expansion of methylenecyclopropanesM. E. Scott, W. Han, M. Lautens*, Org. Lett., 2004, 6(19), 3309-3312

THF, reflux, 16 h

MgI2

13 examples (6594%, only one isomer observed in all but 2 examples) 82%, one isomer

SN

O

N

SN

O

N ONPh2

O

NPh2

56159 Asymmetric transfer hydrogenation in water with a supported NoyoriIkariya catalystX. Li, X. Wu, W. Chen, F. E. Hancock, F. King, J. Xiao*, Org. Lett., 2004, 6(19), 3321-3324

The catalyst could be reused more than 10 times with no loss in enantioselectivity

water, 22 C, 18 h

Ru-PTsDPEN

16 examples (>87% yield, 8594% ee) 87% yield, 91% ee

OO

OOH

Ru-PTsDPEN =

NTsRu

H2N

O O

Cl

HCO2Na

56160 Palladium-catalyzed dimerization disilylation of 1,3-butadiene with chlorosilanesJ. Terao, A. Oda, N. Kambe*, Org. Lett., 2004, 6(19), 3341-3344

THF, 20 C

Pd(acac)2

7 examples (5793%, >78 : 22 E : Z) 88%, E isomer only

Ph Si Cl SiMe2PhSiMe2Ph

PhMgBr

56161 Organic reactions in water: an efficient zinc-mediated stereoselective synthesis of (E)- and(Z)-trisubstituted alkenes using unactivated alkyl halidesB. Das*, J. Banerjee, G. Mahender, A. Majhi, Org. Lett., 2004, 6(19), 3349-3352

Zn, sat. aq. NH4Cl

21 examples (5886%, Z : E >80 : 20 for X = CN, 0 : 100 for X = CO2Me)

OAcX I

X

X = CNX = CO2Me

rt, 12 hrt, 10 h

80%, 94 : 6 Z : E84%, 0 : 100 Z : E


Organic Letters

56162 Chemoselective cyclizations of divinyl ketones to cyclohexenones mediated by Lewis acid and baseN. A. Magomedov*, P. L. Ruggiero, Y. Tang, Org. Lett., 2004, 6(19), 3373-3375

toluene, 23 C

2,6-di-t-butylphenol,Me3Al, Et3N

6 examples (7492%) 91%

O

SO2Ph

OSO2Ph

56163 ROMPgel-supported thiazolium iodide: an efficient supported organic catalyst for parallel Stetter reactionsA. G. M. Barrett*, A. C. Love, L. Tedeschi, Org. Lett., 2004, 6(19), 3377-3380

DMF, 80 C, 20 h

catalystcatalyst =

15 examples (6899% yield, >66% purity) 95% yield, >95% purity

O OO Ph

N

Sn

INEt3

OHC

56164 Catalytic enantioselective conjugate addition of trimethylsilylacetylene to 2-cyclohexen-1-oneY.-S. Kwak, E. J. Corey*, Org. Lett., 2004, 6(19), 3385-3388

tBuOMe, 0 C, 45 min O ONi

catalyst =

86% yield8288% ee

O

Me2Al SiMe3

O

SiMe3

NN

O OCN

Ph Ph

catalyst

56165 Highly enantioselective dimerization of ,-enones catalyzed by a rigid quaternary ammonium saltF.-Y. Zhang, E. J. Corey*, Org. Lett., 2004, 6(19), 3397-3399

The products could be converted to -chiral -keto acids by treatment with ozone, followed by hydrogen peroxide

50% aq. KOH,toluene, 40 C, 12 h

catalystcatalyst =

7 examples (7981% yield, 8398% ee) 89% yield, 90% eeF

O

F

O O

FN

NH

H

HOH

Br

56166 A 1,3-diaza-Claisen rearrangement that affords guanidinesA. M. Bowser, J. S. Madalengoitia*, Org. Lett., 2004, 6(19), 3409-3412

CHCl3, rt

EDCIEDCI =

7 examples (6685%) 72%

N

Ph

N NN

C HClTs

NH

NH

SN

N

NTs

PhH

H

56167 Chiral norbornadienes as efficient ligands for the rhodium-catalyzed asymmetric 1,4-addition ofarylboronic acids to fumaric and maleic compoundsR. Shintani, K. Ueyama, I. Yamada, T. Hayashi*, Org. Lett., 2004, 6(19), 3425-3427

dioxaneH2O, 50 C, 3 h

[RhCl(C2H4)2]2, ligand ligand =


N

O

OF

B(OH)2N

O

OF


Organic Letters

56168 Azadiene DielsAlder cycloaddition of fulvenes: a facile approach to the [1]pyrindine systemB. Hong*, J. Wu, A. Gupta, M. Hallur, J. Liao, Org. Lett., 2004, 6(20), 3453-3456

ClC6H5, microwave, 125 C, 0.337 h


87% yield

+

CO2Et

NSO2Ph N

H

H

CO2Et

SO2Ph

56169 Regioselective cross-metathesis reaction induced by steric hindranceS. BouzBouz*, R. Simmons, J. Cossy*, Org. Lett., 2004, 6(20), 3465-3467

CH2Cl2, 40 C14 examples

(2383% yield)80% yield

+(5 mol%) Ru catalyst

OTBDPS

OMe

OOMe

O

OTBDPS

56170 One-pot homolytic aromatic substitutions/HWE olefinations under microwave conditions for the formationof a small oxindole libraryA. Teichert, K. Jantos, K. Harms, A. Studer*, Org. Lett., 2004, 6(20), 3477-3480

2) microwave, 6 min, KOt-Bu, PhCHO


75% yield

1) microwave, 2 min, DMF, 180 C, 0.03 MN

PEtO

O

OEtO

N

O

N

OPh

56171 Highly regioselective synthesis of tetrahydro-2H-1,3-thiazin-2-ones via rhodium-catalyzed carbonylationof N-alkylisothiazolidinesC. Dong, H. Alper*, Org. Lett., 2004, 6(20), 3489-3492

(0.05 mmol) KI, toluene, CO (1000 psi), 24 h9 examples


(0.05 mmol) [Rh(COD)Cl]2

HS

N n N

S O H

n

56172 2-C-branched glycosides from 2-carbonylalkyl 2-O-Ms(Ts)-C-glycosides. A tandem SN2SN2 reaction via1,2-cyclopropanated sugarsH. Shao, S. Ekthawatchai, S. Wu, W. Zou*, Org. Lett., 2004, 6(20), 3497-3499

K2CO3/MeOH, rt, overnight13 examples


MeOHO

BnOBnO

BnO

Me

O

OMsO

BnOBnO

BnO

Me

O

56173 Cp*Ir complex catalyzed N-heterocyclization of primary amines with diols: a new catalytic system forenvironmentally benign synthesis of cyclic aminesK. Fujita*, T. Fujii, R. Yamaguchi*, Org. Lett., 2004, 6(20), 3525-3528

NaHCO3, toluene, 110 C, 17 h14 examples


[Cp*IrCl2]2NH2 + HO OH N


Organic Letters

56174 Very efficient phosphoramidite ligand for asymmetric iridium-catalyzed allylic alkylationA. Alexakis*, D. Polet, Org. Lett., 2004, 6(20), 3529-3532

NaHC(CO2Me)2, THF, 2565 C, 266 h20 examples

(2199% yield1098% ee) 90% yield97% ee

[IrCODCl]2ligandOCO2Me

Cl

CH(CO2Me)2

+Cl

Cl

CH(CO2Me)2OO

P N

Me

Me

ligand =(6 examples)

56175 Synthesis and trimethylaluminum additions on -hydroxy--sulfinyl and sulfonyl enoatesM. Carreno*, M. Sanz-Cuesta, F. Colobert*, G. Solladie*, Org. Lett., 2004, 6(20), 3537-3540

CH2Cl2, 17 h, 0 C4 examples


AlMe3p-Tol

EtO

O

OH O

p-Tol

OOH

OHMeMe

56176 Palladium-catalyzed benzylation of active methine compounds without additional base: remarkableeffect of 1,5-cyclooctadieneR. Kuwano*, Y. Kondo, Org. Lett., 2004, 6(20), 3545-3547

THF, 80 C, 372 h23 examples

(71>99% yield) 84% yield

Cp(3-C3H5)PdDPPF

HOCOMe

O +H C CO2Et

CO2Et

Ph H CO2Et

CO2Et

Ph

56177 Synthesis of a new monodentate spiro phosphoramidite ligand and its application in Rh-catalyzedasymmetric hydrogenation reactionsS. Wu, W. Zhang, Z. Zhang, X. Zhang*, Org. Lett., 2004, 6(20), 3565-3567

H2 (25 psi)8 examples

(99.799.9% ee) 98.2% ee

(0.001 mmol) [Rh(nbd)2]BF4-ligandCOOCH3

NHAcH

COOCH3

NHAcH*

56178 Unsymmetrical hybrid ferrocene-based phosphine-phosphoramidites: a new class of practical ligands forRh-catalyzed asymmetric hydrogenationX. Hu, Z. Zheng*, Org. Lett., 2004, 6(20), 3585-3588

CH2Cl2, H2 (10 bar), rt, 0.51 h7 examples

(10.699% ee) 99.6% ee

Rh(COD)2BF4-ligand

H

HN

O

H

HN

O

*

ligand =(6 examples)

O

OPN

PPh2

Fe

56179 Novel [2 + 2 + 2 + 1] cycloaddition of enediynes catalyzed by rhodium complexesB. Bennacer, M. Fujiwara, I. Ojima*, Org. Lett., 2004, 6(20), 3589-3591

Cl(CH2)2Cl/toluene, CO (1 atm) 5080 C, 2136 h

8 examples(1193% yield) 87% yield

(5 mol%) [Rh(COD)Cl]2OMeOMeMeO

MeO

O

MeOMeO

OMeOMe


Organic Letters

56180 A new ketone synthesis by palladium-catalyzed cross-coupling reactions of esters with organoboroncompoundsH. Tatamidani, F. Kakiuchi, N. Chatani*, Org. Lett., 2004, 6(20), 3597-3599

dioxane, 50 C, 10 h14 examples


(0.03 mmol) Pd(OAc)2(0.09 mmol) PPh3OPy

ClO

Ph

OCl

56181 Highly enantioselective asymmetric hydrogenation of -acetamido dehydroamino acid derivatives using athree-hindered quadrant rhodium catalystH. Wu, G. Hoge*, Org. Lett., 2004, 6(20), 3645-3647

solvent, H2 (650 psi), THF/MeOH, EtOAc

7 examples(6699% ee)

96% ee

(1 mol%) Rh catalystCO2Et

NHAcPr

CO2Et

NHAcPr

56182 Tin-free radical cyclizations for the synthesis of 7-azaoxindoles, 7-azaindolines,tetrahydro[1,8]napthyridines, and tetrahydro-5H-pyrido[2,3-b]azepin-8-onesE. Bacque, M. El Qacemi, S. Zard*, Org. Lett., 2004, 6(21), 3671-3674

lauroyl peroxide, 1,2-dichloroethane,

Numerous examples3799% yield

R S O

SN NCln

Olauroyl peroxide, chlorobenzeneN NCl

n

O

SR

EtOS

N NClO

Rn

56183 Highly efficient stereoconservative amidation and deamidation of -amino acidsD. Shendage, R. Frolich, G. Haufe*, Org. Lett., 2004, 6(21), 3675-3678

ii) 1,4-dioxane, reflux, 5 h13 examples(098% yield)

96% yield

i) NaNO2, Ac2OAcOH (2 : 1),

04 C, 1416 hPhtN

NHMe

O

Me

PhtNOMe

O

Me

56184 Mercuric triflate-catalyzed synthesis of 2-methylfurans from 1-alkyn-5-onesH. Imagawa, T. Kurisaki, M. Nishizawa*, Org. Lett., 2004, 6(21), 3679-3681

C6H6, 0.520 h, rt9 examples


(5 mol%) Hg(OTf)2O O

56185 Stereoselective synthesis of multisubstituted butadienes through directed MizorokiHeck reaction andhomocoupling reaction of vinyl(2-pyridyl)silaneK. Itami*, Y. Ushiogi, T. Nokami, Y. Ohashi, J. Yoshida*, Org. Lett., 2004, 6(21), 3695-3698

CH3CN, rt, 3 h15 examples

(24>99% yield) 70% yield

(11.2 equiv) CuI(1.31.5 equiv) CsF

SiMe2Py

S S

S


Organic Letters

56186 Racemic but tropos (chirally flexible) BIPHEP ligands for Rh(I)-complexes: highly enantioselectiveene-type cyclization of 1,6-enynesK. Mikami*, S. Kataoka, Y. Yusa, K. Aikawa, Org. Lett., 2004, 6(21), 3699-3701

(20 mol%) TfOH, (CH2Cl2)2, 525 C, 0.519 h


84% yield88% ee

(10 mol%) catalyst

Cl

O

Me

ClMe

O

*

N

NH2

H2

PPh2

PRh+

Ph2

Catalyst =

56187 Preparation of tertiary amides from carbamoyl chlorides and organocupratesL. Lemoucheux, T. Seitz, J. Rouden*, M. Lasne, Org. Lett., 2004, 6(21), 3703-3706

THF/Et2O, 300 C, 2 h19 examples


(t-Bu)2CuLiLiCNN Cl

O

Nt-Bu

O

56188 Ring-closing metathesis of 2,2-divinylbiphenyls: a novel and general approach to phenanthrenesA. Luliano*, P. Piccioli, D. Fabbri, Org. Lett., 2004, 6(21), 3711-3714

CH2Cl2/toluene, 25110 C, 224 h


(10 mol%) catalyst

H3CO

Catalyst (2 examples)OCH3

N N

RuPCy3Cl

Cl

56189 Cp2Fe(PR2)2PdCl2 (R = i-Pr, t-Bu) complexes as air-stable catalysts for challenging Suzuki couplingreactionsT. Colacot*, H. Shea, Org. Lett., 2004, 6(21), 3731-3734

EtOHH2O, K2CO3,12 h, 80 C


93% yield

(0.01 eq.) catalystCatalyst (7 examples)

FBr

MeO

PhB(OH)2 + FPh

MeO

PPd

Pt-Bu2

Cl

Clt-Bu2

56190 Synthesis of carbazoles and dibenzofurans via cross-coupling of o-iodoanilines and o-iodophenolswith silylaryl triflatesZ. Liu, R. Larock*, Org. Lett., 2004, 6(21), 3739-3741

MeCN, CsF, 100 C, 24 h


85% yield

(10 mol%) PCy3(5 mol%) Pd(OAc)2

OH

IMeO2C O

MeO2C


Organic Letters

56191 An efficient synthesis of -C-glycosides based on the conformational restriction strategy: Lewis acidpromoted silane reduction of the anomeric position with complete stereoselectivityM. Terauchi, H. Abe, A. Matsuda, S. Shuto*, Org. Lett., 2004, 6(21), 3751-3754

CH2Cl2, 78 C, 60 min


90% yield

Et3SiH, TMSOTfOOBn

Ph

OHBnO

OO

MeO

OMe

OOBn

PhBnO

OO

MeO

OMe

56192 Regioselective enzymatic acylation of -L-2-deoxynucleosides: application in resolution of-D/L-2-deoxynucleosidesJ. Garcia, S. Fernandez, M. Ferrero, Y. Sanghvi, V. Gotor*, Org. Lett., 2004, 6(21), 3759-3762

THF, 30 C, 0.5192 h

4 examples(1495% yield

>99% ee)90% yield>99% ee

lipaseLevO

NO OHT

OH

+

O OLevT

OH

56193 Enantioselective aldol reaction of trimethoxysilyl enol ether catalyzed by lithium binaphtholateM. Nakajima*, Y. Orito, T. Ishizuka, S. Hashimoto, Org. Lett., 2004, 6(21), 3763-3765

H2O, THF, 23 C, 0.5 h

11 examples(7598% yield

897% ee (syn)095% ee (anti))

94% yield>97% ee (syn)84% ee (anti)

(10 mol%) catalyst

CHO

+

OSi(OMe)3 O OH catalyst =Br

OLiOLi

Br

56194 Efficient and selective removal of methoxy protecting groups in carbohydratesA. Boto*, D. Hernandez, R. Hernandez, E. Suarez, Org. Lett., 2004, 6(21), 3785-3788

(diacetoxyiodo)benzene, I2, CH2Cl2, 25 C, h (80 w)


82% yield

OMeO OH

OMeOMe

MeOO

O

OMeOMe

MeO+

O

OO OH

OMeOMe

MeO

AcO

56195 Environmentally benign synthesis of H-phosphonic acids using a water-tolerant, recyclablepolymer-supported catalystS. Deprele, J. Montchamp*, Org. Lett., 2004, 6(21), 3805-3808

H3PO2, CH3CN, N2, refluxrt, 312 h, 15 runs


91% yield

(0.5 mol%) Pd catalystCl Cl PO2H2 N ONH

O PPh2

PPh2

Pd

Catalyst =


Synthesis

56196 Application of phosphineoxazoline ligands in Ir-catalyzed asymmetric hydrogenation of acyclic aromaticN-aryliminesA. Trifonova, J. Diesen, C. Chapman, P. Andersson*, Org. Lett., 2004, 6(21), 3825-3827

CH2Cl2, N2 (20 bar), rt

9 examples(099% conversion

6696% ee)98% conversion

90% ee

(0.5 mol%) catalyst

Catalyst (2 examples) =

MeO

N

MeO

HN

*

N

Ph

IrPh

O

N

i-PrH

56197 An ionic liquid-coordinated palladium complex: a highly efficient and recyclable catalyst for the HeckreactionJ. Xiao, B. Twamley, J. Shreeve*, Org. Lett., 2004, 6(21), 3845-3847

ionic liquid, NaCO3, 100 C, 4 h3 examples


(2 mol%) PdCl2Cl + Ph

Ph

56198 Chiral [2.2.2] dienes as ligands for Rh(I) in conjugate additions of boronic acids to a wide range ofacceptorsC. Defieber, J. Paquin, S. Serna, E. Carreira*, Org. Lett., 2004, 6(21), 3873-3876

KOH, dioxane/H2O, 118 h, 50 C16 examples

(4398% yield8898% ee)

93% yield88% ee

(1.5 mol%) [Rh(C2H4)2Cl]2+ PhB(OH)2MeO

O

MeO

O Ph

56199 Synthesis of seven-membered ring glycals via endo-selective alkynol cycloisomerizationE. Alcazar, J. Pletcher, F. McDonald*, Org. Lett., 2004, 6(21), 3877-3880

ii) Ac2O, DMAP


i) (15%) W(CO)6, Et3N, THF,h (350 nm), 5570 C, 6 hO

OMe

Me

HOH

HOO

AcO

O O

Synthesis

56200 Iodine catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones and thiones: a simple and efficientprocedure for the Biginelli reactionK. V. N. S. Srinivas, B. Das*, Synthesis, 2004, (13), 2091-2093

CH3CN, reflux, 7 h


I2

CH3

H

O

H3C OCH2CH3

O O+ +

H2N NH2

O

NH

NH

H3C

H3CH2CO

O

CH3


Synthesis

56201 Simple and improved procedure for the regioselective acylation of aromatic ethers with carboxylic acidson the surface of graphite in the presence of methanesulfonic acidM. H. Sarvari, H. Sharghi*, Synthesis, 2004, (13), 2165-2168

010 C, 20 min


GraphiteMeSO3H+ MeCO2H

OMe

MeO

O

Me

56202 An improved catalytic system, Pd(PPh3)4/PhCOOH combined catalyst, for the allylation of carbonpronucleophiles with allenesN. T. Patil, N. K. Pahadi, Y. Yamamoto*, Synthesis, 2004, (13), 2186-2190

1,4 dioxane, 100 C, 12 h90%10 examples (7090%)

Pd(PPh3)4, PhCOOH+C C CH2

H

Ph

COOEt

COOEt

PhCOOEt

COOEt

56203 A novel four-component reaction for the diastereoselective synthesis of some new spiro pyrrolizidinesvia 1,3-dipolar cycloaddition of azomethine ylidesJ. Azizian*, A. R. Karimi, A. A. Mohammadi, M. R. Mohammadizadeh, Synthesis, 2004, (14), 2263-2265

Reaction proceeds to 7686% yields under reflux for 23 h.

DMSO, 35 min

89%6 examples (8795%)

MW

+

O

O

OHOH

NH2

NH2

+

NH

CO2H

O

O

Cl

+

N

N

N N

O

O

Cl

H

H

+

56204 Highly efficient double-activation catalysts for the synthesis of ketone cyanohydrinsF.-X. Chen, X. Liu, B. Qin, H. Zhou, X. Feng*, G. Zhang, Synthesis, 2004, (14), 2266-2272

rt, 13 h

99%13 examples (8499%)

AlEt3, [L]+

O

N

ONC O Si

OH

N N

HO

[L] =

56205 Ionic liquids promoted multi-component reaction: green appraoch for highly substituted 2-aminofuranderivativesJ. S. Yadav*, B. V. S. Reddy, S. Shubashree, K. Sadashiv, J. J. Naidu, Synthesis, 2004, (14), 2376-2380

rt, 2 h

84%12 examples (7889%)

[bmim]BF4+

MeOOC

COOMe

H

O

+

NC

O NH

MeO2C CO2Me

56206 A new reactive system for HornerWadsworthEmmons olefination of optically active4-hydroxy-2-oxo-alkylphosphonates and 4-hydroxy-1-1chloro-2-oxo-alkylphosphonates with aliphaticaldehydesC. Xu, C. Yuan*, Synthesis, 2004, (15), 2449-2458

H2O, THF94%, >99% ee26 examples (7696%, 95>99% ee)

K2CO3+

PhP(OEt)2

OOH OEtCHO

Ph

OOH

Et


Synthesis

56207 TFFH as an excellent reagent for acylation of alcohols, thiols and dithiocarbamatesM. Pittelkow, F. S. Kamounah, U. Boas, B. Pedersen, J. B. Christensen*, Synthesis, 2004, (15), 2485-2492

DMAP, rt, over night

97%20 examples (3897%)

TFFH+

OH

O

HO O

O

TFFH = N NF PF6

56208 Bi(OTf)3 as novel and efficient catalyst for the stereoselective synthesis of C-pseudoglycalsJ. S. Yadav*, B. V. S. Reddy, K. S. Reddy, L. Chandraiah, V. Sunitha, Synthesis, 2004, (15), 2523-2526

MeCN, rt, 15 min

95%10 examples (8795%)

Bi(OTf)3+

OAcO

OAcAcO

TMSOAcO

AcO

56209 Novel synthetic strategy of N-arylated heterocycles via sequential palladium-catalyzed intra- andinter-arylamination reactionsR. Omar-Amrani, R. Schneider*, Y. Fort*, Synthesis, 2004, (15), 2527-2534

NaH, tBuOH, 1,4-dioxane, 100 C, 8 h

92%19 examples (4199%)

Pd(OAc)2+

Cl

NH2Cl

N

56210 Facile synthesis of 2,3-disubstituted quinoxalines by SuzukiMiyaura couplingL. Mao, H. Sakurai*, T. Hirao*, Synthesis, 2004, (15), 2535-2539

K2CO3, tolueneethanol, reflux, 48 h

92%14 examples (7796%)

Pd(PPh3)4+ PhB(OH)2NN

Cl Cl

NN

Ph Ph

56211 The reaction of carbonyldiimidazole with alcohols to form carbamates and N-alkylimidazolesY. Tang, Y. Dong, J. L. Vennerstrom*, Synthesis, 2004, (15), 2540-2544

MeCN, rt, 2 h

100%28 examples (10100%)

Carbonyl diimidazoleO

O OH

O

O

OO

N

N

56212 Unexpected addition of methyl 3,3,3-trifluoropyruvate to push-pull enamines having a methyl group at-positionD. M. Volochnyuk, A. N. Kostyuk*, D. A. Sibgatulin, A. E. Petrenko, Synthesis, 2004, (15), 2545-2549

Benzene, rt, several hours

84%12 examples (5398%)

F3C OMeO

O

+

(H2C)4NCN

Me

(H2C)4NCN

CO2Me

F3C

HO


Synthesis

56213 The first synthesis of 1,1-dinitrocyclopropaneE. M. Budynina, E. B. Averina, O. A. Ivanova, N. V. Yashin, T. S. Kuznetsova*, N. S. Zefirov, Synthesis, 2004, (16), 2609-2610

benzene, 5 CHC(NO2)3

CH2N2NO2NO2

+O

N

NO2

O

62% 23%

56214 The Huisgen reaction of azomethane ylide to isatins: a facile synthesis of spiro-oxindolesV. Nair*, S. Mathai, A. Augustine, S. Viji, K. V. Radhakrishnan, Synthesis, 2004, (16), 2617-2619

CH2Cl2, rt, 3 h

TFA+

82%

MeSi N

MeMe

Ph

OMe N

O

O

MeN

O

Me

NO

56215 Stereoselective reduction of -hydroxy -ketoesters: a concise synthesis of anti-,-dihydroxy estersM. Liao, W. Yao, J. Wang*, Synthesis, 2004, (16), 2633-2636

CH2Cl2, 63 C to rt, 8 h

NaBH4

11 examples, 6086%

Ph OEt

OH

O

O

Ph OEt

OH

OH

O

56216 A tandem nucleophilic addition, defluorination and destannylation. Stereospecific syntheses oftrifluoromethylated alkyl and aryl vinyl ethersY. Shen*, G. Wang, Synthesis, 2004, (16), 2637-2640

45 h, MeOH or EtOH, reflux

CH3ONa

7 examples, 7395%

SnBu3

F3-CH3C6H4

F3C H

OCH33-CH3C6H4

F3C

56217 Environmentally benign preparation of heteroaromatics from ketones or alcohols, with macroporouspolystyrenesulfonic acid and (diacetoxyiodo)benzene, followed by thioamide, amidine, and2-aminopyridineM. Weno, H. Togo*, Synthesis, 2004, (16), 2673-2677

CH3CN, reflux, 24 h

K2CO3

20 examples, 3193%

S OO

OIPh

OHN NH2 Ph

O+ +

N

OPh

56218 Reactions of 1,4-benzodiazepinic N-nitrosoamides with tosylmethyl isocyanide: a novel synthesis ofmidazolamC. del Pozo*, A. Macias, E. Alonso, J. Gonzalez*, Synthesis, 2004, (16), 2697-2703

78 C

BuLi

5 examples6882%

N

NN

Cl

NOMe

F

Me

SO2CH2CN

+ N

N

Cl

F

NTos


Synthetic Communications


56219 Infrared irradiation: effective promoter in the formation of N-benzylideneanilinesM. A. Vazquez, M. Landa, L. Reyes, R. Miranda, J. Tamariz, F. Delgado*, Synth. Commun., 2004, 34(15), 2705-2718

10 min, no solvent

26 examples (4597%) 95%

IR

Me2N

H

O NH2

Me2N

H

N

56220 A mild and efficient method for cleavage of C1N using imidazolium dichromateS. K. De*, Synth. Commun., 2004, 34(15), 2751-2755

imidazolium dichromateMeCN, reflux, 6 h

17 examples (8294%) 94%

NPh

PhOH O

Ph

Ph

56221 Highly regioselective ring opening of epoxides with polymer supported phenoxide and naphthoxide anionsB. Tamami*, N. Iranpoor, R. Rezaei, Synth. Commun., 2004, 34(15), 2789-2795

ethanol50 C, 1.5 h

28 examples (3096%) 96%

OO

O OOH

C6H4CH2N(CH3)3OC6H5CH3

Me2HC

Me2HC

56222 Titanium dioxide as a mild and efficient catalyst for conversion of epoxides to thiiranesB. Yadollahi*, S. Tangestaninejad, M. H. Habibi, Synth. Commun., 2004, 34(15), 2823-2827

TiO2, NH4SCNMeCN, reflux, 40 min

7 examples (8996%) 96%

O

OPh

S

OPh

56223 Oxidation of benzylic alcohols to carbonyl compounds with potassium permanganate in ionic liquidsA. Kumar, N. Jain, S. M. S. Chauhan*, Synth. Commun., 2004, 34(15), 2835-2842

KMnO4, [bmim][BF4]rt, 1 h

12 examples (8597%) 97%

MeO CH2OH MeO CHO

56224 Potassium fluoride assisted selective acetylation of alcohols with acetic acidJ. W. J. Bosco, B. R. Raju, A. K. Saikia*, Synth. Commun., 2004, 34(15), 2849-2855

80 C, 1.5 h

17 examples (3499%) 98%

KFOH OAcMeCO2H

56225 Selective reduction of aldehydes to alcohols using alumina with a catalytic amount of base undermicrowave irradiationP. K. Pradhan, P. Jaisankar, B. Pal, S. Dey, V. S. Giri*, Synth. Commun., 2004, 34(15), 2863-2872

Al2O3, DMAPMW 300 W (2 x 5 min), MeOH

11 examples (8095%) 95%

OHC NO2 HOH2C NO2



56226 Regioselective synthesis of chromeno[4,3-c] isoquinolin-11-ones by radical cyclizationK. C. Majumdar*, S. Sarkar, Synth. Commun., 2004, 34(16), 2873-2883

Bu3SnCl3, Na(CN)BH3AIBN, C6H6, reflux, 34 h, N2 atmosphere

O

MeN

Me3C

O

Br

O

Me3C

O8 examples6568%

56227 An eco-friendly synthesis of electrophilic alkenes catalyzed by dimethylaminopyridine under solvent-freeconditionsA. V. Narsaiah, A. K. Basak, B. Visali, K. Nagaiah*, Synth. Commun., 2004, 34(16), 2893-2901

DMAP

8085 C, 2.54 h15 examples7595%

CHO+

CN

CO2Et

CO2Et

CN

56228 Selective thioacetalization of aldehydes catalyzed by aqueous zinc tetrafluoroborateS. Islam, A. Majee*, T. Mandal, A. T. Khan, Synth. Commun., 2004, 34(16), 2911-2916

CH2Cl2, rt, 5900 min

21 examples7095%

+

CHOHS

SH HCS

SZn(BF4)

56229 Direct synthesis of N-acylalkylenediamines from carboxylic acids under mild conditionsB. P. Bandgar*, S. V. Bettigeri, Synth. Commun., 2004, 34(16), 2917-2924

triphenylphosphine, NBS2555 min, DCM

21 examples7797%

CH3(CH2)2COOH + HN NH

O

NCH3(CH2)NH

56230 A convenient preparation of enantiopure endo-2-hydroxyepicamphor and endo-3-hydroxycamphor fromcamphoric acidQ. Tan, D. Li, H. Bao, Y. Wang, J. Wen, T. You*, Synth. Commun., 2004, 34(16), 2945-2950

The starting compound is easily prepared from camphoric acid

MeOH, N2, 25 C, 12 h; or THF, HCl, 25 C

2 examples7191%

OSiMe3

OSiMe3

OH

O

H

56231 N-methylmorpholine N-oxide: a rare nonmetallic catalyst for the most efficient silylcyanation of aldehydesS. S. Kim*, G. Rajagopal, D. W. Kim, D. H. Song, Synth. Commun., 2004, 34(16), 2973-2980

1030 min, CH2Cl2

12 examples7598%

Me3SiCN, N-methylmorpholine N-oxide

H

O

CN

OSiMe3



56232 Synthesis of diacetals from aldehydes and ketones with pentaerythritol catalyzed by silica sulfate undermicrowave irrradiationT.-S. Jin*, H.-X. Wang, K.-F. Wang, T.-S. Li, Synth. Commun., 2004, 34(16), 2993-2999

benzene or toluene, 0.55.0 h

17 examples8098%

silica sulphate, hH

O O

O

O

O

56233 One-pot syntheses of amides from N-acylation of nitroarenes with esters mediated by samarium diiodideX. Wang*, H. Guo, G. Xie, Y. Zhang, Synth. Commun., 2004, 34(16), 3001-3008

THF, rt

11 examples8295%

NO2+ C

OOCH2CH3H3C

HN

CCH3

O

SmI2

56234 Synthesis of N,N-bis(2-thiazolinyl)-, N,N-bis(2-thiazolyl)-, and N,N-bis(2-pyrimidinyl)-benzenedicarboxamidesS. R. Gondi, D. Y. Son*, Synth. Commun., 2004, 34(17), 3061-3072

124 h,

EtOAcMeOHNS

NH2

+

COCl

COCl

COHN

COHN

S

N

S N 10 examples3484%

56235 Zirconium(IV) chloride catalyzed cyclization of ortho-allylphenols: synthesis of2-methyl-2,3-dihydrobenzofuransH. M. Meshram*, K. Premalatha, K. Rameshbabu, B. Eeshwaraiah, J. S. Yadav, Synth. Commun., 2004, 34(17), 3091-3097

820 h, DCM, 0 C rt, N2 atmosphere

ZrCl4

10 examples6085%OH

CH2HC

COMe

CH2

MeOC

O

56236 Efficient synthesis of 3-substituted coumarinsS. H. Mashraqui*, D. Vashi, H. D. Mistry, Synth. Commun., 2004, 34(17), 3129-3134

CH3CN, , N2, reflux, 28 h

2-chloro-1-methylpyridinium iodide(C2H5)3N

13 examples6391%

CHO

OH+

CH2CO2H

O O

56237 Silica-supported sodium hydrogen sulfate catalyzed facile transformation of p-hydroxybenzyl alcohols top-hydroxybenzyl ethers and thioethersR. Ramu, N. R. Nath, M. R. Reddy, B. Das*, Synth. Commun., 2004, 34(17), 3135-3145

1.52 h, rtNaHSO4/SiO2

21 examples8095%

+

HO

OHOH

HO

OMe



56238 Trimethylsilyl chloride: a facile and efficient reagent for one-pot synthesis of3,4-dihydropyrimidin-2(1H)-onesY. Zhu, Y. Pan*, S. Huang, Synth. Commun., 2004, 34(17), 3167-3174

rt, DMFCH3CN, 13 h

TMSCl

28 examples7697%

+OC2H5

O O

H2N NH2

O+ C6H5CHO H5C2O

NH

NH

O C6H5

O

56239 Facile and efficient deoxygenation of amine-N-oxides with gallium in waterJ. H. Han, K. I. Choi, J. H. Kim, B. W. Yoo*, Synth. Commun., 2004, 34(17), 3197-3201

0.524 h, reflux, H2O

Ga

9 examples8195%

N

CN

ON

CN

56240 A facile synthesis of 4-Ar-2-bromopyridine and its 2,2-bipyridine derivativesX.-F. Duan*, X.-H. Li, F.-Y. Li, C.-H. Huang, Synth. Commun., 2004, 34(17), 3227-3233

THF, 40 C, Pd(PPh3)4

4-CH3C6H4MgBr

3 examples4570%N

I

N

4-CH3C6H4

Br Br

56241 A novel route to 3-(O,O-diethylphosphoryl)-2,3-dihydrofurans via rhodium-catalyzed heterocycloadditionreactionD. Ging, L. Zhang, C. Yuan*, Synth. Commun., 2004, 34(18), 3251-3258

85 CH3CP

OEt

O

N2

OOEt Rh2(OAc)4Et

O+ O N

Et

H3C P(O)(OEt)2

5 examples7690%

56242 Nitration of cinnamic acids using cerium(IV) ammonium nitrate immobilized on silicaA. Messere, A. Gentili, I. Garella, F. Temussi, B. Di Blasio, A. Fiorentino*, Synth. Commun., 2004, 34(18), 3317-3324

TFA, MgSO4, rt, 20 min

CeNH4(NO2)5/SiO2

3 examples5790%

HO

COOH

HO

COOH

NO2

56243 Microwave-assisted synthesis of dihydropyrimidines in solvent-free conditionM. Mirza-Aghayan*, M. Bolourtchian, M. Hosseini, Synth. Commun., 2004, 34(18), 3335-3341

The reaction proceeds in solvent-free conditions.

2030 s, h

FeCl36H2O

8 examples3868%

O

+ Me OEt

O O

+ H2N NH2

O

NH

NEtO

O

Me O

H



56244 Nickel-catalyzed electrochemical synthesis of dihydro-benzo[b]thiophene derivativesJ. Pelletier, S. Olivero, E. Dunach*, Synth. Commun., 2004, 34(18), 3343-3348

CH3CN, electrolysis

Ni(cyclam)(BF4)25 examples5973%

Br

S S

56245 Improved synthesis of 7-(alkyl/aralkyl)guaninesA. Vidal*, I. Giraud, J.-C. Madelmont, Synth. Commun., 2004, 34(18), 3359-3365

DMA or acetic acid, HCl, 148 h, rt120 C

alkylating agent (e.g. CH3CH2I, 11 examples)

11 examples5197%

O

HO OH

HON

N N

NH

O

NH2N

N N

NH

O

NH2

CH3H2C

HCl

56246 Synthesis of iodinated naphthoquinones using morpholineiodine complexA. L. Perez*, G. Lamoureux, A. Herrera, Synth. Commun., 2004, 34(18), 3389-3397

rt, pH 2, 1060 min

K2CO3 H2O or dichloroethane

3 examples5587%

OOH

O

+O

N IH

I

OOH

OI

56247 RuCl3 catalyzed facile conversion of arylalkyl ketoximes to amidesS. K. De*, Synth. Commun., 2004, 34(18), 3431-3434

reflux, CH3CN, 1.59 h

RuCl3

11 examples4891%

NH3C

H5C6

OHC6H5NHCOCH3

56248 Synthesis of fused imidazoles based on -bromodypnoneV. Kovtunenko*, L. Potikha, A. Turov, Synth. Commun., 2004, 34(19), 3069-3613

benzene, reflux+

OPh

Ph

Br N

N NH2

N

N NH

Ph

PhO

Br

56249 A rapid and convenient synthesis of homallylic alcohols by the BarbierGrignard reactionG. J. Sormunen, D. E. Lewis*, Synth. Commun., 2004, 34(19), 3473-3480

Mg

Et2OO

C10H7+ Br

HO

H7C107 examples3482%

56250 The synthesis of 9,10-dihydro-9,10-(methaniminomethano)anthracene and N-protected derivatives viadouble reductive aminationP. Stoy, J. Rush, W. H. Pearson*, Synth. Commun., 2004, 34(19), 3481-3489

PMBNH2, NaBH3CN

78 or 6080 C, MeOH

4 examples4093%

CHO

CHO

PMP-N



56251 Novel and efficient method to synthesize N-benzyl-4-formyl-piperidineR. Sheng, Y. Hu*, Synth. Commun., 2004, 34(19), 3529-3533

MgBr2Et2O

NaOH, 2080 C3886%

H2C N O

H2C N H

O

+ (CH3)3S+IO

56252 Novel synthesis of 2-oxo-2H-benzopyrano[2,3-d]pyrimidinesH. Turki, S. Abid, Y. le Bigot, S. Fery-Forgues, R. El Gharbi*, Synth. Commun., 2004, 34(19), 3553-3563

215 h, 65 C, MeOH

6 examples2088%

+

O

NEt

Et

CN

N COEt

OEt CH2NH2

NEt

EtO

N

NNHCH2

O

56253 Efficient tetrahydropyranylation of alcohols and detetrahydropyranylation reactions in the presence ofcatalytic amount of trichloroisocyanuric acid (TCCA) as a safe, cheap industrial chemicalH. Firouzabadi*, N. Iranpoor*, H. Hazarkhani, Synth. Commun., 2004, 34(19), 3623-3630

MeOH, TCCA, rt, 38 h

dihydropyran, 6080 C, 548 hOH O

33 examples7595%

33 examples9096%

TCCA: trichloroisocyanuric acid

N N

NCl

O

ClO

Cl

O

56254 -PCC and -PCC-SiO2 as efficient reagents for oxidation of thiols to disulfidesM. M. Khodaei*, P. Salehi, M. Goodarzi, A. Yazdanipour, Synth. Commun., 2004, 34(20), 3661-3666

-PCC-SiO2CH2Cl2, rt, 4 h

12 substrate examples (3895%) 95%

CH2SH

56255 Potassium dodecatungstocobaltate trihydrate (K5CoW12O403H2O) as an efficient catalyst for aminolysisof epoxidesE. Rafiee*, S. Tangestaninejad, M. H. Habibi, V. Mirkhani, Synth. Commun., 2004, 34(20), 3673-3681

MeCN, reflux, 5.5 h90 examples (4599%) 99%

K5CoW12O403H2OOCl H2N Br

OH

CH2ClNHBr

56256 Efficient and selective formation of mixed acetals by Nafion-H SAC-13 silica nanocomposite solid acidcatalystI. Ledneczki, A. Molnar*, Synth. Commun., 2004, 34(20), 3683-3690

reflux, 5 min32 examples (up to 100%) 100%

SAC-13OH (BuO)2CH2 O

CH2OBu

56257 Stereoselective synthesis of cis-1-aryl-2-benzoyl-3,3-dicyanocyclopropanes in the presence of KF2H2OZ. Ren*, W. Cao, W. Ding, Y. Wang, L. Wang, Synth. Commun., 2004, 34(20), 3785-3792

DME, rt, 4 h

11 examples (8695%) 95%

KF2H2OC6H5CH C(CN)2CN

CNC6H5

COPh

Ph3AsCH2COPhBr


Tetrahedron

56258 Microwave-induced rapid access to aromatic and heteroaromatic sulfonamides under solvent-freeconditions without using external baseA. K. Sharma, S. K. Das*, Synth. Commun., 2004, 34(20), 3807-3819

6 min

28 examples (3094%) 94%

MW

NH2

Br Br

HN

SMeSO2Cl

Ph

O O

56259 Bismuth subnitrate catalyzed efficient synthesis of 3,4-dihydropyrimidin-2(1H)-ones: an improvedprotocol for the Biginelli reactionY. T. Reddy, B. Rajitha*, P. N. Reddy, B. S. Kumar, V. P. Rao, Synth. Commun., 2004, 34(20), 3821-3825

MeCN, 7080 C, 1.5 h

17 examples (8896%) 96%

BiONO3O O

Ph H NH2 NH3 Me OMe

O O

NH

N

Ph

O

O

MeO

Tetrahedron

56260 Calcium phosphate-vanadate apatite (CPVAP)-catalyzed aerobic oxidation of propaygylic alcohols withmolecular oxygenY. Maeda, Y. Washitake, T. Nishimura*, K. Iwai, T. Yamauchi, S. Uemura*, Tetrahedron, 2004, 60(41), 9031-9036

n-PrCN, 100 C, 20 h, O2 (1 atm)


Calcium phosphate vanadate apatite

Me

OH

Me

O

56261 Enantioselective oxidative coupling of methyl 3-hydroxy-2-naphthoate using mono-N-alkylatedoctahydrobinaphthyl-2,2-diamine ligandK. H. Kim, D.-W. Lee, Y.-S. Lee, D.-H. Ko, D.-C. Ha*, Tetrahedron, 2004, 60(41), 9037-9042

CH2Cl2

98%, 42% ee15 examples (5699%)

CuCl, O2, mol sieves, [N]CO2Me

OH

CO2Me

OH

CO2Me

OH

NH2NH2

[N] =

56262 Scope and limitation of montmorillonite K 10 catalysed opening of epoxide rings by amineA. K. Chakraborti*, A. Kondaskar, S. Rudrawar, Tetrahedron, 2004, 60(41), 9085-9091

rt, 3 h


Montmorillonite K 10O

NH2

+

HO HN


Tetrahedron

56263 -Hydroxy carboxylic acids as ligands for enantioselective diethylzinc additions to aromatic and aliphaticaldehydesT. Bauer*, J. Gajewiak, Tetrahedron, 2004, 60(41), 9163-9170

Et2Zn, 28 C, 19 h97%, 77% ee18 substrates (7097%, 5283% ee)

H3CO CHO H3COOH

OH

O

HO

Ph

56264 Enantioselective total synthesis of ()-strychnine: development of a highly practical catalytic asymmetriccarboncarbon bond formation and domino cyclizationT. Ohshima, Y. Xu, R. Takita, M. Shibasaki*, Tetrahedron, 2004, 60(43), 9569-9588

KO-t-Bu THF, rt, 4 mol sieve

95%, >99% ee9 examples (7496%, 93>99% ee)

[Al]+

CO2Me

O CO2MeO

CO2Me

CO2MeH

OO

AlOO

Li[Al] =

56265 Sequential ring-closing metathesis/Pd-catalyzed, Si-assisted cross-coupling reactoins: general synthesisof highly substituted unsaturated alcohols and medium-sized rings containing a 1,3-cis-cis diene unitS. E. Denmark*, S.-M. Yang, Tetrahedron, 2004, 60(43), 9695-9708

rt, 30 min

92%11 examples (9193%)

TBAF, Pd(dba)2Si

O

Me Me OH

I

OMe+

56266 Combinatorial approach to the asymmetric hydrogenation of -acylamino acrylates: use of mixtures ofchiral monodentate P-ligandsM. T. Reetz*, X. Li, Tetrahedron, 2004, 60(43), 9709-9714

CH2Cl2

92%171 examples (8.3100%, 13.498.8% ee)

L2Rh(COD)BF4R'

HNO

CO2R''

R' = CH3, C2H5, n-C3H7, C6H5R'' = CH3, C2H5

R'

HNO

CO2R''

L = chiral monodentate P ligands

56267 Palladium-catalyzed -arylation of N-protected 2-piperidinonesA. de Filippis, D. G. Pardo, J. Cossy*, Tetrahedron, 2004, 60(43), 9757-9767

THF, 65 C

97%38 examples (099%)

Pd(dba)2, [L][L] =N

BnO Br

NBn

O

+NH2

Cy2P

56268 Highly diastereo- and enantioselective reactions of enecarbamates with an aldehydeR. Matsubara, P. Vital, Y. Nakamura, H. Kiyohara, S. Kobayashi*, Tetrahedron, 2004, 60(43), 9769-9784

CH2Cl2

95%, 98% ee17 examples (8297%, 9498% ee)

CuClO44CH3CN, [L][L] =

+

O

EtOO

H HN

Ph

O

OBnMe

O

EtOOH

Me

N

Ph

O

OBnN N

p-Br-C6H4 p-Br-C6H4


Tetrahedron Letters

Tetrahedron Letters

56269 Palladium-catalysed three component synthesis of ,-unsaturated amidines and imidatesK. Kishore, R. Tetela, R. J. Whitby*, M. E. Light, M. B. Hurtshouse, Tetrahedron Lett., 2004, 45(38), 6991-6994

tBuNCPdCl2, dppf, Cs2CO3, 65 C, toluene, 1530 min

PhBr NH

Ph N

NtBu

56270 Palladium catalysed synthesis of cyclic amidines and imidatesC. G. Saluste, S. Crumpler, M. Furber, R. J. Whitby*, Tetrahedron Lett., 2004, 45(38), 6995-6996

PdCl2, dppftoluene, 220 h, 109 C, Cs2CO3 or NaOtBu

3884%12 examples

Br

NH2tBuNC N

HN tBu

56271 Preparation of the conjugated polyene chains with the 1,4-dimethyl substitutionH.-S. Jeon, S. Koo*, Tetrahedron Lett., 2004, 45(38), 7023-7026

n-BuLi, DBUTHF, benzene

5292%4 examples

Cl CO2Et

CO2Et SO2Ph CO2Et

CO2Et

56272 Nitroalkanes and ethyl glyoxalate as common precursors for the preparation of both -keto esters and,-unsaturated estersR. Ballini*, D. Fiorini, A. Palmieri, Tetrahedron Lett., 2004, 45(38), 7027-7029

MeSO2Cl, Amberlyst A-21Et3N, CH2Cl2, rt then 0 C, 1.5 h

6594%12 examples

H3CH2C NO2

O

OEtO

H3CH2C

NO2COOEt

56273 -Addition of activated methylenes to alyknoates. A straightforward synthesis of multifunctionalcompoundsM. Hanedanian, O. Loreau, F. Taran*, C. Mioskowski*, Tetrahedron Lett., 2004, 45(38), 7035-7038

PPh3AcOHAcONatoluene, 80110 C, up to 4h

2388%11 examples

COOEt

O O

COOEt

OOH

56274 Regioselective Pd-catalyzed alkylative lactonizations of 4-hydroxy-2-alkynecarboxylates withorganoboronic acidsC. H. Oh*, S. J. Park, J. H. Ryu, A. K. Gupta, Tetrahedron Lett., 2004, 45(38), 7039-7042

AcOH, 1,4-dioxane, 80 C

yield: 70%ee: 95%

EtOOCEtOOC

O

PhB(OH)2EtOOCEtOOC

O

Pd(PPh3)4


Tetrahedron Letters

56275 A novel glycosidation of glycosyl fluoride using a designed ionic liquid and its effect on thestereoselectivityK. Sasaki, S. Matsumura, K. Toshima*, Tetrahedron Lett., 2004, 45(38), 7043-7047

protic acid, ionic liquid25 C, 14 h

8289%6 examples

OBnO

BnO BnO F

BnO

HOOBnO

BnO BnO O

BnO

56276 A convenient synthesis of 3-amino-4-imino(thioxo)-imidazolidin-2-onesT. Kurz*, K. Widyan, Tetrahedron Lett., 2004, 45(38), 7049-7051

CDI or CDT & Et3N or THF, NaH, H2NNHC6H5

5773%10 examples

EtO PO

EtONH

CN EtO PO

EtOHN

N

NH

NH

OC6H5

56277 A two-step synthesis of aminopropylpiperidines via aminopropargylpyridines, suitable for the synthesisof a new class of 5-HT4 ligandsO. Russo, M. Alami*, J.-D. Brion, S. Sicsic, I. Berque-Bestel*, Tetrahedron Lett., 2004, 45(38), 7069-7072

Et3N, DMF, 80 C, PdCl2(PPh3)2CuI

5393%6 examples

KN(Boc)2

N Br Br+

NNBoc2

56278 The simple solvent-free synthesis of 1H-quinazoline-2,4-diones using supercritical carbon dioxide andcatalytic amount of baseT. Mizuno*, T. Wai, Y. Ishino, Tetrahedron Lett., 2004, 45(38), 7073-7075

scCO2, 10 MPa, 80 C, 4 h

4 examples5497%

baseNH2

CNNH

HN

O

O

56279 Highly stereoselective synthesis of the indolo[2,3-a]quinolizine ring system and application to indolenatural product synthesisS. M. Allin*, C. I. Thomas, J. E. Allard, K. Doyle, M. R. J. Elsegood, Tetrahedron Lett., 2004, 45(38), 7103-7105

rt, 20 h

yield: 95%de 100%

HCl, EtOH

N

O

NHO

H

NH

NH

O

HOH


Tetrahedron Letters

56280 General facile synthesis of 2,5-diarylheteropentalenesP. Vachal*, L. M. Toth, Tetrahedron Lett., 2004, 45(38), 7157-7161

Na2Co3, H2O, DMF, 2585 C, 23 h

9 examples7491%

PhI, Pd(Ph3P)4HS(HO)2B

S

Ph

56281 Iodine-catalyzed synthesis of -keto enol estersR. S. Bhosale, S. V. Bhosale, S. V. Bhosale, T. Wang, P. K. Zubaidha*, Tetrahedron Lett., 2004, 45(39), 7187-7188

I2, alcoholrt, 37 min

O

O

O

OMe

9396%9 examples

56282 Synthesis of -hydroxy nitriles and 1,3-amino alcohols from epoxides using acetone cyanohydrin as aLiCN precursorJ. A. Ciaccio*, M. Smrtka, W. A. Miao, D. Rucando, Tetrahedron Lett., 2004, 45(39), 7201-7204

LiCNacetone0.253 h, THF

6590%12 examples

O OH

(CH2)10CH3NC OH

(CH2)10CH3

HO

56283 Catalysis of highly stereoselective Mannich-type reactions of ketones with -imino esters by apyrrolidine-sulfonamide. Synthesis of unnatural -amino acidsW. Wang*, J. Wang, H. Li, Tetrahedron Lett., 2004, 45(39), 7243-7246

rt, DMSO, 220 h

yield: 7491%ee: 9699%8 examples

NH HN S

O

OCF3

O+

N

HEtO2C

PMP

CO2Et

O NHPMP

56284 Enantioselective syntheses of bicyclo[3.1.0]hexane carboxylic acid derivatives by intramolecularcyclopropanationN. Yoshikawa*, L. Tan, N. Yasuda, R. P. Volante, R. D. Tillyer, Tetrahedron Lett., 2004, 45(39), 7261-7264

3857%2 examples

1. pyrrolidine, reflux2. TBSCl. imidazole, DMF, rt3. NMO, OsO4, acetoneH2O, rt4. SOCl2, Et3N, toluene, 0 C5. LiHMDS, THF, 78 C

O

H

H

HHHO

HOTBS

O

N


Tetrahedron Letters

56285 An efficient and green protocol for the preparation of cycloalkanols: a practical synthesis of venlafaxineS. P. Chavan*, D. A. Khobragade, S. K. Kamat, L. Sivadasan, K. Balakrishnan, T. Ravindranathan, M. K. Gurjar, U. R. Kalkote,Tetrahedron Lett., 2004, 45(39), 7291-7295

5697%12 examples

H2O, 45120 min, phase transfer catalysis

NaOH or KOH

OMe

CN

O

+

OMe

CNOH

56286 Synthesis of 1,2-dihydroisoquinolines via the reaction of ortho-alkynylarylamines with bis--allylpalladiumM. Ohtaka, H. Nakamura, Y. Yamamoto*, Tetrahedron Lett., 2004, 45(39), 7339-7341

Cu(OAc)2, CH3CN, 50 C

+

NBn

PhSnBu3

Cl+

PdCl

PdCl

N

Ph

Bn

56287 A novel procedure for the synthesis of multifunctional ketones through the Fukuyama coupling reactionemploying dialkylzincsY. Mori, M. Seki*, Tetrahedron Lett., 2004, 45(39), 7343-7345

ZnBr, THF, toluene, DMF, 20 C, 1748 h

Et2Zn, Pd/C

MeO

O

SEt

O

O

Et

5695%6 examples

56288 Highly regioselective ring opening of epoxides using NaN3: a short and efficient synthesis of()-cytoxazoneJ. Boruwa, J. C. Borah, B. Kalita, N. C. Barua*, Tetrahedron Lett., 2004, 45(39), 7355-7358

CH3CN, 1.01.6 h

NaN3, 4 molecular sieves

9097%9 examples

O

Cl N3 Cl

OH

56289 Bismuth trichloride catalyzed synthesis of -aminonitrilesS. K. De*, R. A. Gibbs, Tetrahedron Lett., 2004, 45(40), 7407-7408

BiCl3, TMSCNCH3CN, rt, 510 h

CHO + NH2 HN

CN


Tetrahedron Letters

56290 Synthesis of 4b,5,10a,11-tetrahydroindeno[1,2-b]-quinolin-10-ones from BaylisHillman adductsC. G. Lee, Y. Lee, S. GowriSankar, J. N. Kim*, Tetrahedron Lett., 2004, 45(40), 7409-7413

PPA120170 C, 0.518 h

NH HN

O

+

N7 examples5062%

5 examples422%

56291 A simple, efficient, and highly selective method for the iodination of alcohols using ZrCl4/NaIH. Firouzabadi*, N. Iranpoor*, M. Jafarpour, Tetrahedron Lett., 2004, 45(40), 7451-7454

ZrCl4/NaI2120 min, CH3CN

14 examples7597%

OH I

56292 Curtius rearrangement and Wolff homologation of functionalized peroxidesP. H. Dussault*, C. Xu, Tetrahedron Lett., 2004, 45(40), 7455-7457

EtOC(O)Cl then CH2N2

11 examples4799%

O OH

t-BuO O

O CHN2

t-BuO O

56293 Quinone methide initiated cyclization reaction: synthesis of 4-aryl-1,2,3,4-tetrahydroisoquinolinesB. C. Raju*, P. Neelakantan, U. T. Bhalerao*, Tetrahedron Lett., 2004, 45(40), 7487-7489

3 examples7886%

MeO

MeONHTS

+

H3COBn

CH3

CH2Br

H3COH

CH3

NTsHN

OMe

OMe

1. NaH/DMF2. Pd/C, H23. Ag2O, DCM4. ZnCl2, DCM

56294 Opening of epoxides with aromatic amines promoted by indium tribromide: a mild and efficient methodfor the synthesis of -amino alcoholsJ. R. Rodriguez, A. Navarro*, Tetrahedron Lett., 2004, 45(40), 7495-7498

16 examples6596%

+InBr3

CH2Cl2, rtO

7tBu NH2 7

OHNH

tBu

56295 Synthesis and reactivity of enantiomerically pure N-alkyl-2-alkenyl azetidinium saltsF. Couty*, F. Durrat, G. Evano, D. Prim, Tetrahedron Lett., 2004, 45(40), 7525-7528

7 examples6994%up to 72%

KHMDS or PhLi

N

Ph

Bn MeMe

N

Ph

Me

PhTfO

Bn


Books, Reviews and Conference Proceedings

Books, Reviews and Conference Proceedings

56296 DNA-Templated organic synthesis: Natures strategy for controlling chemical reactivity applied tosynthetic moleculesX. Li, D. R. Liu*, Angew. Chem., Int. Ed., 2004, 43(37), 4848-4870

A review, with 172 references, describing some representative early examples of nucleic acid templated synthesis,an analysis of current understanding of this technique, emerging applications and future challenges.

56297 N-Heterocyclic carbenes: reagents, not just ligands!V. Nair*, S. Bindu, V. Sreekumar, Angew. Chem., Int. Ed., 2004, 43(39), 5130-5135

A review, with 37 references, covering the use of N-heterocyclic carbenes as catalyst and nucleophilic reagents intransesterification, nucleophilic aromatic substitution, cycloaddition and asymmetric reactions.

56298 In the golden age of organocatalysisP. I. Dalko*, L. Moisan, Angew. Chem., Int. Ed., 2004, 43(39), 5138-5175

A review, with 251 references, covering the use of organic compounds as catalysts in a diverse range of reactions.

56299 Stereoselective synthesis using diastereotopic groupsR. W. Hoffmann*, Synthesis, 2004, (13), 2075-2090

A review, with 104 references, of stereoselective synthesis using diastereotopic group differentiating reactions,with conformationally flexible molecules.

56300 Palladium catalysts for the Suzuki cross-coupling reaction: an overview of recent advancesF. Bellina, A. Carpita, R. Rossi*, Synthesis, 2004, (15), 2419-2440

A review, with 206 references, of work until March 2004 on new catalyst systems for palladium catalysed Suzukicross-coupling rections of organic electrophiles and organoboron compounds.

56301 Intermolecular CH insertions of donor/acceptor-substituted rhodium carbenoids: a practical solution forcatalytic enantioselective CH activationH. M. L. Davies*, O. Loe, Synthesis, 2004, (16), 2595-2608

A review, with 58 references, covering recent developments in the rhodium-catalyzed intermolecular CHinsertion chemistry of diazo compounds.

56302 Current methods for the synthesis of 2-substituted azolesC. A. Zificsak, D. J. Hlasta*, Tetrahedron, 2004, 60(41), 8991-9016

A review, with 256 references, of recent literature focusing on new methods of substitution to construct CC bondsin preparing azole derivatives.

56303 The Reformatsky reaction in organic synthesis. Recent advancesR. Ocampo, W. R. Dolbier, Jr.*, Tetrahedron, 2004, 60(42), 9325-9374

A review, with 369 references, of the recent progress in the uses of Reformatsky reactions in synthetic organicchemistry. Included are recent work in diastereo- and enantioselective reactions.


Author Index

Author Index

Abe, H. 56191Abid, S. 56252Aikawa, K. 56186Alami, M. 56277Albert, M. 56151Albu, S. 56096Alcazar, E. 56199Alesi, S. 56107Alexakis, A. 56174Allard, J. E. 56279Allin, S. M. 56279Alonso, E. 56218Alper, H. 56171Alves, E. F. 56110Anderson, K. 56128Andersson, P. 56196Aubert, C. 56127Augustine, A. 56214Averina, E. B. 56213Azizian, J. 56203Bacque, E. 56182Balakrishnan, K. 56285Ballini, R. 56124, 56272Bandgar, B. P. 56229Banerjee, J. 56161Bao, H. 56230Barboni, L. 56124Barrett, A. G. M. 56163Barua, N. C. 56288Basak, A. K. 56227Bauer, T. 56263Beller, M. 56083, 56086Bellina, F. 56300Bennacer, B. 56179Bergmann, R. G. 56089,

56090Berque-Bestel, I. 56277Bettigeri, S. V. 56229Bhalerao, U. T. 56293Bhor, S. 56086Bhosale, R. S. 56281Bhosale, S. V. 56281, 56281Biermann, U. 56134Bindu, S. 56297Blaszczyk, A. 56153Boas, U. 56207Bolm, C. 56157Bolourtchian, M. 56243Borah, J. C. 56288Boruwa, J. 56288Bosco, J. W. J. 56224Boto, A. 56194BouzBouz, S. 56169Bovin, Y. 56156Bowser, A. M. 56166Braga, A. L. 56110Brion, J.-D. 56277Bryliakov, K. P. 56085Buchwald, S. 56128Budynina, E. M. 56213Cadran, N. 56127Campbell, J. E. 56143Cao, W. 56257Cariou, K. 56127Carlo, G. 56124

Carpita, A. 56300Carreira, E. 56198Carreno, M. 56175Castedo, L. 56133Chakraborti, A. K. 56262Chan, A. S. C. 56104Chan, K. S. 56104Chandraiah, L. 56208Chandrasekhar, S. 56108Chapman, C. 56196Chatani, N. 56180Chauhan, S. M. S. 56223Chavan, S. P. 56285Chavarot, M. 56103Che, C.-M. 56082Chen, F.-X. 56204Chen, J. 56082Chen, W. 56159Cho, G. Y. 56157Choi, K. I. 56239Choudary, B. 56126Christensen, J. B. 56207Ciaccio, J. A. 56282Ciufolini, M. A. 56156Colacot, T. 56189Colobert, F. 56175Corey, E. J. 56164, 56165Cossy, J. 56169, 56267Couty, F. 56295Cozzi, P. G. 56107Crumpler, S. 56270Cui, J. 56105Dalko, P. I. 56298Das, B. 56161, 56200,

56237Das, S. K. 56258Davies, H. M. L. 56142,

56301De, S. K. 56220, 56247,

56289de Filippis, A. 56267Defieber, C. 56198del Pozo, C. 56218Delgado, A. 56133Delgado, F. 56219Deng, J. G. 56100Denmark, S. E. 56265Deprele, S. 56195Dey, S. 56225Di Blasio, B. 56242Diesen, J. 56196Ding, K. 56135Ding, W. 56257Dingerdissen, U. 56083Dobler, C. 56086Dolbier, W. R., Jr. 56303Dommisse, R. A. 56109Dong, C. 56171Dong, Y. 56211Doyle, K. 56279Duan, X.-F. 56240Dunach, E. 56244Durrat, F. 56295Dussault, P. H. 56292Early, T. R. 56098

Ebitani, K. 56139Eeshwaraiah, B. 56235Ekstrand, M. 56106Ekthawatchai, S. 56172El Gharbi, R. 56252El Qacemi, M. 56182Elbing, M. 56153Elsegood, M. R. J. 56279Enthaler, S. 56083Evano, G. 56295Fabbri, D. 56188Feng, X. 56204Fensterbank, L. 56127Fernandez, S. 56192Ferrero, M. 56192Fery-Forgues, S. 56252Fiorentino, A. 56242Fiorini, D. 56272Firouzabadi, H. 56253,

56291Fort, Y. 56209Frolich, R. 56183Fujii, T. 56173Fujioka, S. 56148Fujita, K. 56173Fujita, K.-i. 56092Fujiwara, M. 56179Funabiki, K. 56093Furber, M. 56270Gajare, A. S. 56119Gajewiak, J. 56263Garcia, J. 56192Garella, I. 56242Gentili, A. 56242Ghosh, R. 56152Gibbs, R. A. 56289Ging, D. 56241Giralt, E. 56121Giraud, I. 56245Giri, V. S. 56225Godet, T. 56156Gommermann, N. 56102Gondi, S. R. 56234Gonzalez, J. 56218Goodarzi, M. 56254Gotor, V. 56192Goushi, S. 56093GowriSankar, S. 56290Guo, H. 56233Gupta, A. 56168Gupta, A. K. 56274Gupta, M. K. 56101Gurjar, M. K. 56285Guy, I. L. 56097Ha, D.-C. 56261Habibi, M. H. 56222, 56255Hagemann, B. 56083Hallur, M. 56168Hampel, N. 56091Han, J. H. 56239Han, W. 56158Hancock, F. E. 56159Hanedanian, M. 56273Hara, T. 56139Harms, K. 56170

Harrowven, D. C. 56097Hashimoto, S. 56193Haufe, G. 56183Hayashi, T. 56167Hazarkhani, H. 56253Hazell, R. G. 56096Hernandez, D. 56194Hernandez, R. 56194Herrera, A. 56246Herve, G. 56127Hirao, T. 56210Hlasta, D. J. 56302Hoffmann, M. 56091Hoffmann, R. W. 56299Hoge, G. 56181Holmes, A. B. 56098Hong, B. 56168Hosseini, M. 56243Hoveyda, A. 56140Hoveyda, A. H. 56143Hu, J. 56084, 56114Hu, X. 56178Hu, Y. 56251Hua, Z. 56155Huang, C.-H. 56240Huang, S. 56238Hugl, H. 56086Hurtshouse, M. B. 56269Ichikawa, E. 56151Ikagawa, A. 56145Ikariya, T. 56145Imagawa, H. 56184Iranpoor, N. 56221, 56253,

56291Ishino, Y. 56278Ishizuka, T. 56193Islam, S. 56228Itami, K. 56185Ivanova, O. A. 56213Iwai, K. 56260Jafarpour, M. 56291Jagadeesh, B. 56101Jain, N. 56223Jaisankar, P. 56225Jansson, J. 56157Jantos, K. 56170Jasoni, R. L. 56114Jeon, H.-S. 56271Jiao, N. 56115Jin, Q. 56142Jin, T. 56112Jin, T.-S. 56232Jin, Z. 56155Johannesen, S. A. 56096Johnson, J. S. 56120Junge, K. 56083Kacprzynski, M. 56140Kakiuchi, F. 56180Kalita, B. 56288Kalkote, U. R. 56285Kamat, S. K. 56285Kambe, N. 56160Kamijo, S. 56112Kamounah, F. S. 56207Kanai, M. 56151

METHODS IN ORGANIC SYNTHESIS January

Sythesis and the reagents

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