Systemic Inflammatory Response Syndrome (SIRS) Prognosis
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Systemic Inflammatory Response Syndrome (SIRS) is an inflammatory state affecting the whole body, frequently in response to infection.
Transcript of Systemic Inflammatory Response Syndrome (SIRS) Prognosis
Systemic Inflammatory Response Syndrome(SIRS) Prognosis
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Systemic Inflammatory Response Syndrome (SIRS) is an inflammatory state affecting the whole body, frequently in response to infection.
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Phase Angle a Prognostic Factor for Survival in SIRS
SIRS is nonspecific and not always related to infection. It is related to Sepsis,a condition in which individuals both meet criteria for SIRS and have a known or highly suspected infection.
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INFECTION SIRSSEPSIS
Phase Angle a Prognostic Factor for Survival in SIRS
SIRS is defined as 2 or more of the following variables:Fever of more than 38°C or less than 36°CHeart rate of more than 90 beats per minuteRespiratory rate of more than 20 breaths per minute or a PaCO2 level of less than 32 mm HgAbnormal white blood cell count (>12,000/µL or <4,000/µL or >10% bands)
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Phase Angle a Prognostic Factor for Survival in SIRS
SIRS is one of several conditions related to systemic inflammation, organ dysfunction, and organ failure.
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SIRS
Pancreatitis
Trauma
Burns
Bacteraemia
Irradiation??
Infection
Phase Angle a Prognostic Factor for Survival in SIRS
Leucocytes
Endothelialcells
Complement
Plasmatichemocoagulationsystem
Platelets
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Phase Angle a Prognostic Factor for Survival in SIRS
The causes of SIRS are broadly classified as
infectious or noninfectious.
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Causes:
When SIRS is due to an infection, it is considered sepsis.
Noninfectious causes of SIRS include trauma, burns, pancreatitis, ischemia and haemorrhage.
Phase Angle a Prognostic Factor for Survival in SIRS
Septic shock is severe sepsis with hypo tension (systolic BP < 90mmHg) despite adequate fluid resuscitation or the requirement for vasopressors/inotropes to maintain blood pressure.
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Phase Angle a Prognostic Factor for Survival in SIRS
Here is an excerpt of the clinical observation study from 23rd International Symposium on Intensive Care and Emergency Medicine.
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It was concluded from the study that phase Angle acts as a predictor for survival in patients
with SIRS.
Phase Angle a Prognostic Factor for Survival in SIRS
PrognostiCheck® for prognosis based upon a noninvasive diagnostic test measures the resistance,reactance and phase angle (in degrees).A low phase angle has been associated with an altered cellular membrane function.
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Phase Angle a Prognostic Factor for Survival in SIRS
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Phase Angle a Prognostic Factor for Survival in SIRS
Tests were conducted on 30 consecutive patients( 11 female, 19 male ,median age of 67 [ 16.5 ] years ) after admitting them to the intensive care unit ,all of whom met 2 or more SIRS Criteria.
In Septic shock patients,a phase angle of less than 4 degree has been reported to be associated with increases mortality.
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Severity of the illness was characterized according to APACHE II(Acute Physiology and Chronis Health Evaluation)
Phase Angle a Prognostic Factor for Survival in SIRS
Non-invasive impedance analysis was performed using a tetra-polar hand-to-foot measuring device and derived phase angle was calculated as arc tan (reactance/resistance).
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increasing
Reactance ( )
Phase Angle a Prognostic Factor for Survival in SIRS
All measurements were performed in the supine position of the patient with special care.
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After 28 days, out of the 30 patients investigated, 10 had died and 20 survived.
In seven out of 20 survivors,a phase angle of more than 4 degree was measured on the first day study,whereas in all patients who died,the phase angle was less than 4 degree (P=0.038)
Phase Angle a Prognostic Factor for Survival in SIRS
The conclusion was that an initial phase angle of more than 4 degree may be correlated with survival,in patients suffering with SIRS.
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Phase Angle a Prognostic Factor for Survival in SIRS
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