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Synthesis of thienyl appended porphyrins for cancer treatment by edith amuhaya
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Transcript of Synthesis of thienyl appended porphyrins for cancer treatment by edith amuhaya
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Synthesis of Thienyl-appended Porphyrins for
Cancer TreatmentDr. Edith K. Amuhaya
Technical University of Kenya28/11/2014
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Cancer StatisticsGlobal
Cancers among the leading causes of morbidity and mortality worldwide.
14 million new cases and 8.2 million cancer related deaths in 2012.
New cases expected to rise by about 70% by 2030.
Kenya
Third leading cause of death.
39,000 new cases annually
28,000 deaths annually
WHO, 2014 http://www.who.int/mediacentre/factsheets/fs297/en/Githanga, 2013
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Cancer Treatment
http://www.jerryryanphd.com/biopage.html
http://www.tirgan.com/vp16.htm
http://medgadget.com/archives/2008/07/varians_rapidarc_radiation_delivery_system_goes_clinical.html
SURGERY
CHEMOTHERAPY
RADIATION THERAPY
3
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Photodynamic Therapy (pdt)
PDT is a relatively new mode of treatment.
Components of PDT•Light of appropriate wavelength
•Oxygen
•Light sensitive drug (Photosensitizer)
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Jablonski Diagram
http://www.discoverymedicine.com/Diana-M-Tacelosky/files/2012/04/discovery_medicine_no_71_brian_m_barth_figure_1.png
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Drug Administration
• Administration of drug
• Incubation period
• Irradiation of tumor by light of desired wavelength.
http://belfield.cos.ucf.edu/pdt.html
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Porphyrin-Based Photosensitizers
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Synthesis of Dipyrromethane
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Synthesis of thienyl-appended porphyrins
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Synthesis of thienyl-appended porphyrins
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Photophysical Studies
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Biological Studies
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Biological Studies
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Future Work
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Acknowledgements
• Technical University of Kenya
• Prof. M.G.H. Vicente (LSU, USA)
• Prof. Kevin M. Smith (LSU, USA)
• Dist. Prof. Tebello Nyokong’ (Rhodes University, SA)
• KESHO- Kenya