SYNOPSIS OF RESEARCH ACTIVITIES IN THE FACULTY OF … 72.pdf · University of Toronto Rooms 2331 -...

SSYYNNOOPPSSIISS OOFF RREESSEEAARRCCHH AACCTTIIVVIITTIIEESS IN THE FACULTY OF MEDICINE UNIVERSITY OF TORONTO AND ITS AFFILIATED TEACHING HOSPITALS April 2004 - March 2005

Version 3: 17 August 2006

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PRODUCED BY: Office of the Vice Dean, Research and International Relations Faculty of Medicine University of Toronto Rooms 2331 - 2340 1 King’s College Circle Toronto, Ontario M5S 1A8 CANADA Contact person: GJ Baylon, MD Coordinator, Research Information (416) 978 – 8339 [email protected]

TABLE OF CONTENTS Message from the Vice Dean, Research and International Relations ......................................IV Acknowledgements ........................................................................................................................XI Terms of Reference........................................................................................................................XII Tables and Figures Table 1: Summary of Department Research Funding vs Sponsor in THOUSANDS of Dollars....... 1 Table 2: 5-year Departmental Research Funding in THOUSANDS of Dollars By Campus vs

Affiliated Hospital Location..................................................................................................... 2 Table 3: Department Research Funding vs Location, All Sponsors for the year 2004/05 in

THOUSANDS of dollars......................................................................................................... 3 Table 4: Summary of Location Research vs Sponsor (Funding Source) in THOUSANDS of

Dollars .................................................................................................................................... 4 Table 2A: Research Funding 3-year Averages By Department for the periods: 2000-03, 2001-

04, 2002-05 ............................................................................................................................ 5 Table 2B: Research Funding 3-year Averages By Department in 2000 CONSTANT Dollars

for the periods: 2000-03, 2001-04, 2002-05.......................................................................... 6 Table 3A: Three-year AVERAGE of Department Research Funding vs Location, All Sponsors

for the years 2002/03, 2003/04 and 2004/05 in THOUSANDS of Dollars............................ 7 Table 3B: Three-year AVERAGE of Department Research Funding vs Location - Tri-Council

(CIHR / NSERC / SSHRC) only for the years 2002/03, 2003/04 and 2004/05 in THOUSANDS of Dollars ........................................................................................................ 8

Table 4A: Research Funding 3-year Averages By Location of Research for the periods: 2000-03, 2001-04, 2002-05............................................................................................................. 9

Table 4B: Research Funding 3-year Averages By Location of Research in 2000 CONSTANT Dollars for the periods: 2000-03, 2001-04, 2002-05 ........................................................... 10

Table 5: Research Funding By Source in THOUSANDS of Dollars, 8-year Distribution Profile .... 11 Figure 1: Comparison of Research Funding by Sponsor Source: 1987 to 2005............................ 12 Table 6: Research Funding By Type of Grant ................................................................................. 13 Table 7: Research Personnel by Department ................................................................................. 14 Table 8: Summary of Research Personnel Located at Affiliated Teaching Hospitals .................... 15 Table 9: Research Space at the University of Toronto Campus by Department............................ 16 Table 10: Graduate Student Funding (Awards and Stipends) by Income Source Type................ 17 Table 11: Graduate Student Funding (Awards and Stipends) by Graduate Unit........................... 18 Table 12: Graduate Student Funding (Awards and Stipends) by Administrative Location and

Source .................................................................................................................................. 19

Synopsis of Research Activities of the Faculty of Medicine 2004 - 2005

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Synopsis of Research Activities of the Faculty of Medicine 2004 - 2005 v3

Departmental Synopses Notes to Faculty of Medicine Departments...................................................................................... 20 Summary of Department research funding and personnel ............................................................. 21 Anaesthesia...................................................................................................................................... 22 Banting and Best Department of Medical Research ....................................................................... 23 Biochemistry ..................................................................................................................................... 24 Family and Community Medicine..................................................................................................... 25 Health Policy, Management and Evaluation.................................................................................... 26 Immunology...................................................................................................................................... 27 Inst. of Biomaterials & Biomedical Engineering............................................................................... 28 Laboratory Medicine and Pathobiology ........................................................................................... 29 Medical Biophysics........................................................................................................................... 30 Medical Genetics & Microbiology..................................................................................................... 31 Medical Imaging ............................................................................................................................... 32 Medicine ........................................................................................................................................... 33 Nutritional Sciences.......................................................................................................................... 34 Obstetrics and Gynaecology............................................................................................................ 35 Occupational Therapy. ..................................................................................................................... 36 Ophthalmology and Vision Sciences ............................................................................................... 37 Otolaryngology ................................................................................................................................. 38 Paediatrics........................................................................................................................................ 39 Pharmacology................................................................................................................................... 40 Physical Therapy.............................................................................................................................. 41 Physiology ........................................................................................................................................ 42 Psychiatry ......................................................................................................................................... 43 Public Health Sciences..................................................................................................................... 44 Radiation Oncology.......................................................................................................................... 45 Speech-Language Pathology........................................................................................................... 46 Surgery ............................................................................................................................................. 47 Affiliated Teaching Hospital Synopses Notes to the Affiliated Teaching Hospitals ....................................................................................... 48 Summary of Hospital research funding and personnel ................................................................... 49 Baycrest Centre for Geriatric Care................................................................................................... 50 Bloorview Kid’s Rehab ( formerly The Bloorview MacMillan Children’s Centre) ............................ 51 Centre for Addiction and Mental Health........................................................................................... 52 The Hospital for Sick Children.......................................................................................................... 53


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Mount Sinai Hospital ........................................................................................................................ 54 St. Michael’s Hospital ....................................................................................................................... 55 Sunnybrook & Women’s College Health Sciences Centre, Orthopaedic & Arthritic Site ............... 56 Sunnybrook & Women’s College Health Sciences Centre, Sunnybrook Site................................. 57 Sunnybrook & Women’s College Health Sciences Centre, Women’s College Site ....................... 58 Toronto Rehabilitation Institute ........................................................................................................ 59 University Health Network................................................................................................................ 60 Intra/Extradepartmental Centre, Group, Institute, and Program Synopses Notes to Summary of Intra/Extradepartmental Units....................................................................... 61 Banting and Best Diabetes Centre................................................................................................... 62 Joint Centre for Bioethics ................................................................................................................. 63 Clinical Science Division .................................................................................................................. 64 The Wilson Centre for Research in Education ................................................................................ 65 The Gage Occupational & Environmental Health Unit .................................................................... 66 Centre for Health Promotion ............................................................................................................ 67 Centre for International Health ........................................................................................................ 68 R.S. McLaughlin Centre for Molecular Medicine ............................................................................. 69 Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research ........................ 70 Centre for Research in Neurodegenerative Diseases..................................................................... 71 Positron Emission Tomography (PET) Centre ................................................................................ 72 Centre for Sleep Medicine & Circadian Biology............................................................................... 73 Centre for the Study of Pain............................................................................................................. 74 Centre for Research In Women’s Health ......................................................................................... 75 Bone and Mineral Group .................................................................................................................. 76 Drug Safety Research Group........................................................................................................... 77 Institute of Medical Science ............................................................................................................. 78 Institute for Work & Health ............................................................................................................... 79 Cardiovascular Sciences (Collaborative Program).......................................................................... 80 Multi Organ Transplant Program...................................................................................................... 81 Program in Neuroscience................................................................................................................. 82 Structural Genomics Consortium..................................................................................................... 83 Industrial Funding Sources .............................................................................................................. 84 Other Funding Sources .................................................................................................................... 87


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MESSAGE FROM THE VICE DEAN, RESEARCH AND INTERNATIONAL RELATIONS

This synopsis includes the activities by researchers situated on campus and at the research institutes of the following 9 fully affiliated hospitals: Baycrest Centre for Geriatric Care, Bloorview MacMillan Children's Centre, The Centre for Addiction and Mental Health, The Hospital for Sick Children, Mount Sinai Hospital, St. Michael's Hospital, Sunnybrook & Women’s, Toronto Rehab Institute and the University Health Network for the period 2004/05*

Highlights of 2004-2005 • Change from 03/04 in CIHR and total research funding of -1% and 25%,

respectively • Canada Research Chairs (27 Chairs)

Tier 1 Lilianna Attisano Department of Biochemistry Joseph Culotti Medical Genetics & Microbiology Daniel Dumont Department of Medical Biophysics James Dennis Medical Genetics & Microbiology Daniel Drucker Medicine John Floras Department of Medicine Lori Frappier Medical Genetics & Microbiology Cheryl Grady Department of Psychiatry Mitsuhiko Ikura Medical Biophysics Amira Klip Paediatrics Andres Lozano Department of Surgery Freda Miller Medical Genetics & Microbiology Daniela Rotin Biochemistry Michael Salter Physiology Katherine Siminovitch Department of Medicine Juan-Carlos Zuniga-Pflucker Department of Immunology Tier 2

Soenke Behrends Department of Pharmacology Tom Chau Institute for Biomaterials & Biomedical Engineering Paul Frankland Department of Physiology Sheena Josselyn Department of Physiology Alberto Martin Department of Immunology Beverley Orser Department of Anaesthesia Janice Robertson Department of Lab Medicine & Pathobiology Lisa Robinson Department of Paediatric Sharon Straus Department of Medicine Pascal van Lieshout Department of Speech-Language Pathology Allen Volchuk Department of Biochemistry


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• Premier's Research Excellence Award (6 awards) The Ontario government's PREA Program has two primary aims - 1) to improve Ontario's ability to attract and keep highly talented young researchers and graduate students, in order to conduct state-of-the-art research and 2) to enhance the development of promising researchers and students. For 2004 awards were made to Aileen Davis Department of Physical Therapy

Jim Hu Department of Paediatrics

Prabhat Jha Department of Public Health Sciences

Andras Kapus Department of Surgery

Cindi Morshead Department of Surgery

Michael Ohh Department of Laboratory Medicine & Pathobiology

Congratulations to all! The publication of this the 19th edition of the Synopsis marks the end of my fourth year as Vice Dean, Research. The creation of the CIHR, as well as the establishment of federal funding programs including the Canadian Foundation for Innovation (CFI), the Canada Research Chairs (CRC), and Genome Canada; and at the provincial level, the establishment of the Ontario Research Fund (ORF), and the Early Researcher Awards (ERA) have dramatically improved the research climate over the last five years. The health research community in Toronto has benefited from this multitude of funding opportunities and continues to maintain a high rate of growth in its research funding in spite of the almost no growth in the recent CIHR operating budgets (last year we experienced a 1% decrease in CIHR funding– a very worrisome development). Researchers are adapting by tapping other sources of funding as evinced by the dramatic increase (38%) in the “other” funding category represented for example by Network Centres of Excellence and CFI New Opportunities funding. However, we cannot escape the fact that the research engine is running low on fuel. We need a balance between career awards, infrastructure grants and operating funds. At the moment the latter is in short supply. This must change.

Peter N. Lewis, Ph.D. Vice Dean, Research and International Relations July 20,2006 * This synopsis presents research funding data for 2004/05. In 2006 Sunnybrook &

Women’s became Sunnybrook Health Science Centre and Women’s College Hospital. Bloorview MacMillan Children's Centre was renamed Bloorview Kids Rehab.


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SYNOPSIS OF RESEARCH ACTIVITIES 2004 - 2005 The Synopsis of Research Activities in the Faculty of Medicine is published annually by the Faculty Research Office. This is the 19th edition, which covers the period from April 1, 2004 to March 31, 2005. It presents data and analysis of direct research funding and awards received by faculty members in the Faculty of Medicine for this period. These include operating grants, equipment and maintenance grants, and personnel awards to principal investigators, and trainees (graduate students, postdoctoral and clinical fellows) and other research related special grants. Data for the previous four years are presented for comparison. In addition, funding received (as opposed to the total project award) during this period from the Canadian Foundation for Innovation (CFI) and from the Ontario Innovation Trust (OIT) are reported in a separate category. Overhead received and indirect costs such as building maintenance, library and computing services, administrative services, faculty salaries and basic equipment cost and maintenance are not included. Funding received is segregated by departments and by geographic locations: on campus or in the affiliated hospitals. Guidelines defining research funding and its assignment are described in the Terms of Reference on page XII. The Faculty Research Office works closely with all Faculty departments, the affiliated hospitals and hospital research institutes to ensure that the data reported are as complete and accurate as possible.

INTRODUCTION The Faculty of Medicine at the University of Toronto is the largest medical faculty in Canada and ranks at the top in North America. Currently it admits 198 students to its first year of a 4-year undergraduate medical program. At the post-graduate level, it offers 65 specialty training programs leading to certification by the Royal College of Physicians and Surgeons of Canada, or by the College of Family Physicians of Canada. In addition to its primary responsibility in medical education, the Faculty participates heavily in the education of undergraduates in the Faculty of Arts and Science and in other health science faculties. To complete its educational role, members of the Faculty actively supervise a large number of graduate students enrolled in M.Sc. and Ph.D. programs, and organize and teach graduate courses. There are 26 departments in the Faculty including 9 departments in basic science (including the Institute of Biomaterials and Biomedical Engineering), 15 in clinical science (including the departments of Physical Therapy, Occupational Therapy and Speech-Language Pathology) and two in community health. In addition, there are 17 extra-departmental units (EDUs) organized as Centre, Division, Institute, Group, Unit, and Program. These units are inter-departmental in their structure and they engage in multidisciplinary research and education. The Faculty has over 4,000 faculty members holding a range of academic positions that are fully or partly salaried on university budget, or non-salaried. The scope of research activity in the Faculty of Medicine is very broad, ranging from basic science, clinical investigation to community health and the rehab sciences. There is a research continuum from the curiosity-driven to the applied. At one end are studies at the molecular and gene level to create fundamental knowledge crucial to our understanding of


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the normal and the disease biological process, leading to advancements in diagnosis, more effective prevention and treatment of disease. At the other end are research activities on the promotion of health and wellness, the improvement of rehabilitation, the prevention of disability and the development of policy on health and health administration. The Synopsis measures this large research enterprise in terms of its annual research revenues.

RESEARCH FUNDING: 2004 – 2005 Researchers in the Faculty of Medicine receive research funding from national, provincial and foreign funding agencies. These include the Canadian Institutes for Health Research (CIHR), Natural Sciences and Engineering Research Council (NSERC), Social Sciences and Humanities Research Council (SSHRC), Health Canada (HLTH CAN), and the Ontario Ministry of Health (MOH), and disease-oriented agencies such as the National Cancer Institute of Canada (NCIC), the Heart and Stroke Foundation of Ontario/Canada (HSFO/C), the National Institutes of Health, the Howard Hughes Medical Institute of the United States, and the US Department of Defense (Cancer Programs). In 2004/2005, the Faculty received a total of $508 million in research funds from all sources (Table 1), an increase of 25% from the previous year of $407 million. This represents a rolling average growth of about 18% annually (Table 2B). Research grants accounted for about $448 million of this total, personnel awards accounting for the remaining $60 million (Table 6). All three sectors (the basic science, the community health, and the clinical (including rehab) sector) have continued to show a gain from the previous years (Table 2B). CIHR continued to be the single major source of funding accounting for about $122 million of the total, an increase of -1% from $123 million in the previous year. Other major single sources of funding were NCIC ($27 million) and the Ontario Ministry of Health ($17 million), with no change from the previous year. Funding from Health Canada was unchanged at $1.5 million. Funding from other sources including disease-oriented agencies and specific institutional awards increased dramatically from $173 million to $282 million. Funding from industry decreased to $38 million from $45 million. Table 2 and Table 3 show the "on campus" and "affiliated teaching hospital" geographical assignment of total research revenue. Assignment to hospital site was about $383 million, accounting for 75 % of the total. Table 4 presents an analysis of the geographical distribution of grants and awards from the various funding agencies. During this period, investigators located in the affiliated teaching hospitals and on campus received $91 million and $32 million respectively from CIHR. Thus as a group, researchers located on campus maintained their share of about 25% of the total CIHR funding from. Funding from sources identified as "Other" to campus-based investigators was increased by $40 million to about $73 million whereas there was an increase of about $69 million to hospital-based researchers to $209 million.


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GOVERNMENT RESEARCH INFRASTRUCTURE PROGRAMS Canadian Foundation for Innovation (CFI) began its infrastructure funding programs during 1999. At time of writing, CFI has awarded a total of 35 institutional projects from the Faculty and its affiliated hospitals. These projects were based on the following five research platforms identified by the Faculty in consultation with the departments and hospital research institutes:

1. Comprehensive Program in Imaging 2. Models and Mechanisms of Human Disease 3. Promotion, Preservation, Restoration, and Adaptation of Function and Behaviour 4. Information Systems in Health Care Research 5. Proteomics and Bioinformatics.

About $37 million has been received from CFI and OIT, and from Genome Canada for 2004- 2005 down $23 million (38%) from the previous year. This does not include CFI New Opportunities awards which are included in the total research funding.

COMPARISON TO PREVIOUS YEARS Table 2A shows the annual research funding in current dollars by department from 2000 to 2005. The annual changes are analyzed as an average over a 3-year period. Table 2B shows the same data in 2000 constant dollars. All sectors have continued to grow. Overall, total research funding in current dollars over the 5-year period was increased by $223 M, or $176 M in constant dollars since 1998. The research enterprise of the Faculty and its affiliated hospitals has continued to grow (Table 4A). Figure 1 shows that in the 16-year period beginning 1987, research revenue of the Faculty initially followed a linear rate of growth in spite of a slight hiatus from 1993 to 1995, a period of federal budget constraint on research. Recently the growth of research funding has increased sharply. Table 5 presents the research funding by source in this and the previous seven years. Funding from Canadian federal sources showed an increase from $61 M in 1997/98 to nearly $203 M in 2004/05, for 40% of the Faculty total research revenue. Research revenue from provincial sources remained at about 18% of the total about the same as in 1997/98 (14%). Funding from not-for-profit organizations accounts for about 20% of the total, accompanied by a net increase of some $60 M from seven years ago. Industrial funding shows a 25% decrease from last year in its share to about 8% of the total research revenue (Figure 1).

RESEARCH AWARDS The total number of research grants in 2004-2005 was 3,503, up 9% from the previous year of 3,223 (Table 6). The number of research personnel awards to principal investigators has increased by 5% from 161 to 169. 27 Canada Research Chairs were awarded in 2004/05.


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FACULTY RESOURCES Academic Staff The academic staff in the Faculty of Medicine is a heterogeneous group in terms of their source of salary and the kind of academic appointment they hold. For the purpose of this report, there were 4,822 faculty members holding primary academic appointments in the Faculty (Table 7). These primary appointments range from being fully salaried to Status-Only (e.g. those employed and salaried by hospital research institutes). The profile of these faculty members is as follows, with the 2003-2004 figures in parenthesis: 4,822 (4,679) hold primary appointments and of these 4,410 (4,357) are in the affiliated hospitals 318 (322) located on campus and 168 (171) are tenured, while 40 (45) are in the tenure-stream 1,048 (1,255) faculty members held research grants and 179 (241) received career awards The distribution of faculty members by sector, department, and geographical location is summarized and presented in Tables 7 and 8.

Research Fellows Postdoctoral fellows and clinical research fellows are major contributors to the research enterprise of the Faculty. Tables 7 and 8 summarize the distribution of postdoctoral fellows and clinical research fellows in the Faculty.

Graduate Student Funding – data for 2003/04 In 2003/2004 the total graduate student funding (awards and stipends) was $36.6M (33.4 M), of this $19.7M (20.3 M) were awards while $17.0M (13 M) were stipends as shown in Table 10. The award and stipend distribution by the Graduate unit is given in Table 11. The breakdown by administrative site is given in Table 12. The total funding supports about 2000 graduate students. Numbers in parentheses are 02/03


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Research Space On-campus research and research-support space in the Faculty has changed dramatically over the past few years. The Banting Institute, the Best Institute, the FitzGerald Building, the Medical Sciences Building, the McMurrich Building, the Tanz Neuroscience Building, the Gage Research Institute and the buildings at 1 Spadina, 256 McCaul Street, 82 and 88 College Street housed the Faculty for more than thirty five years. Five years ago a 10-storey building (6,700 nasm) at 500 University Avenue was purchased and now houses the Departments of Physical Therapy, Occupational Therapy, Speech- Language Pathology, and the Office of the Associate Dean, Continuing Education. Construction of the $100M Donnelly Centre for Cellular and Biomolecular Research (CCBR) was completed in 2005. The CCBR (10,000 nasm) has 25 faculty and will ultimately house 40 principal investigators and more than 500 research staff. Extensive renovations were made in 04/05 to the Banting Institute to house the Structural Genomics Consortium a $60M joint project with the UK. Three years ago the University purchased the former Board of Education building (155 College Street) which since has been extensively renovated and now houses 3 Faculty Departments – Public Health Sciences, Health Policy, Management and Evaluation, and Family and Community Medicine. The McMurrich Building home to HPME and PHS has been returned to the University for other purposes. The total campus research space of the Faculty of Medicine is 28,166 sq m (Table 9).


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ACKNOWLEGEMENTS We would like to acknowledge the support of Departmental Chairs, Research Directors and UofT/Hospital Research Administrators for providing information on research activities. In a departure from the previous years’ tradition, we are dispensing with listing the names of all the people we wish to thank, this is to avoid the risk of inadvertently leaving someone deserving off the list. Instead we would like to thank collectively the numerous individuals who have contributed in one way or another to the tedious task of producing this report. We hope you will all continue to support our efforts for next year’s report.


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TERMS OF REFERENCE Research funding is summarized in the Synopsis by department and by research location of the principal investigator.* The following guidelines are used to collect research funding information and assign funds in the research database:

• Research funding information is collected from administration offices located on the University of Toronto campus and at the affiliated teaching hospitals for grants and awards received during the period April 1, 2004- March 31, 2005.

• Information is collected on investigators who hold a Faculty of Medicine

appointment.

• This data is assigned to a principal investigator as identified by the grant application or through consultation with the departmental Chair.

• An investigator's research funding information is linked to their primary

departmental affiliation and to a primary research location as identified on the grant application.

• Funds may be assigned to a department in which a principal investigator holds a

cross appointment. The assignment is conditional upon the agreement of the Chairs.

• This summary includes direct research grants only and does not include funding

to implement or maintain research infrastructure.

• Research funding that remains unexpended during a given report period is not carried forward to subsequent reports.

• The data used to generate this report (unless otherwise indicated) was based on

an RIS ‘by-Location’ Report download (data snapshot) at 1011 hrs of May 31, 2006.

• All calculations were done using validated programs in SAS statistical Software

version 9.1 * In practice, research funds are administered through the departments of all investigators, both principal and co-investigator, involved in a research project. The resource allocation contained in this summary may differ from departmental reports.


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DEPARTMENT Total CIHR NSERC NCIC HLTH CAN MOH HSFO/C SSHRC INDUS OTHER# of

AwardsBASICBBDMR 47,242 4,834 416 997 0 0 205 0 1,060 39,731 121Biochemistry 20,754 5,523 514 994 0 0 375 0 220 13,128 227Biomat & Biomed Eng 2,157 705 95 0 0 34 0 0 38 1,284 28Immunology 10,745 3,920 127 716 0 0 176 0 310 5,496 133Medical Biophysics 74,422 8,102 668 10,373 0 0 568 0 1,388 53,323 598Medical Genetics & Microbiology 45,709 15,127 1,053 3,906 0 0 189 0 715 24,718 481Nutritional Sciences 5,016 1,252 585 314 0 0 146 35 1,170 1,513 159Pharmacology 4,056 1,500 96 145 0 0 0 0 139 2,175 102Physiology 11,275 5,175 409 0 0 0 1,051 0 81 4,559 260

SUB-TOTAL 221,376 46,138 3,963 17,445 0 34 2,710 35 5,121 145,927 2,109COMMUNITY HEALTHHealth Policy, Mgmt & Eval 8,478 2,742 113 0 15 1,347 0 38 101 4,123 137Public Health Sciences 24,014 8,275 317 1,182 808 5,916 0 315 181 7,020 431

SUB-TOTAL 32,492 11,017 430 1,182 823 7,263 0 353 282 11,143 568CLINICALAnesthesia 4,262 1,227 6 0 0 0 128 0 527 2,373 100Family & Community Medicine 4,796 1,314 0 0 206 1,394 59 0 805 1,019 57Lab. Medicine & Pathobiology 25,398 6,964 687 1,962 0 197 1,824 0 3,384 10,380 396Medical Imaging 7,340 489 79 0 0 0 0 0 278 6,494 44Medicine 104,876 24,432 322 4,445 161 2,427 4,514 206 14,772 53,599 1,456Obstetrics & Gynaecology 7,125 5,036 0 38 0 258 0 0 323 1,470 79Occupational Therapy 1,418 137 14 0 0 40 0 65 0 1,162 89Ophthalmology And Vision Sci 4,537 750 0 298 0 1,067 20 0 303 2,099 74Otolaryngology 447 251 21 0 0 0 0 0 0 175 11Paediatrics 20,763 6,658 53 381 10 0 733 0 1,983 10,946 375Physical Therapy 2,089 625 57 0 0 546 0 0 0 861 138Psychiatry 25,159 8,542 29 324 72 417 410 79 5,662 9,625 362Radiation Oncology 7,297 520 33 1,440 0 120 0 0 1,295 3,889 73Speech-Language Pathology 1,500 288 17 0 0 244 102 20 0 830 129Surgery 25,571 6,511 276 999 0 120 1,219 0 2,652 13,794 441

SUB-TOTAL 242,578 63,744 1,594 9,887 449 6,830 9,009 370 31,984 118,716 3,824Other 1 11,654 1,366 0 0 250 3,060 45 25 564 6,345 310

TOTAL 508,100 122,265 5,987 28,514 1,522 17,187 11,764 783 37,951 282,131 6,811CFI/OIT 2 37,328 35Indirect Costs 3 1,160 1

GRAND TOTAL 4 546,588 (x $1000) 6,847

1 Includes global research budget of the Institute for Clinical Evaluative Sciences, Structural Genomics Consortium, SARS Laboratory, UofT Equipment maintenance grants, clinical trial grants at the Sunnybrook Hospital/University of Toronto Clinic, ORDCF grants, Ontario Genomics Institute grants, undergraduate summer studentship awards, graduate studentship awards for independent study and Health Communication Research Laboratory in the Faculty of Medicine and Federal Indirect Cost Programme.2 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Site of SWCHSC, University of Toronto and the University Health Network.

4 Excludes a total of $12,946,032 from the Federal Indirect Costs Program awarded to affiliate hospitals.

Table 1FACULTY OF MEDICINE - UNIVERSITY OF TORONTO

Summary of Department Research Funding vs Sponsor in THOUSANDS of DollarsApril 2004 - March 2005

3 Federal Indirect Costs Program awarded to Faculty of Medicine

Synopsis of R

esearch Activities of the F

aculty of Medicine 2004 - 2005

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aculty of Medicine 2004 - 2005 v3

DEPARTMENT Hospital Campus Hospital Campus Hospital Campus Hospital Campus Hospital CampusBASICAnatomy and Cell Biology 1 214 2,281BBDMR 865 6,676 858 7,591 1,626 9,591 3,142 8,539 2,482 44,760Biochemistry 4,542 2,983 6,430 2,875 5,835 4,493 6,035 3,551 16,274 4,479Biomat & Biomed Eng 1,447 695 1,364 594 1,337 464 1,664 452 987 1,170Immunology 4,287 1,784 4,679 908 5,363 1,013 5,870 1,141 9,154 1,591Medical Biophysics 32,353 481 29,201 552 37,811 500 46,157 682 72,793 1,629Medical Genetics & Microbiology 20,481 5,212 24,304 8,710 26,430 8,621 30,314 9,729 37,154 8,555Nutritional Sciences 1,312 2,595 946 2,775 961 2,608 2,034 2,520 1,607 3,410Pharmacology 2,249 2,816 1,290 2,039 1,097 2,565 1,268 2,657 1,339 2,717Physiology 3,693 4,759 3,887 6,436 4,275 6,757 4,763 6,452 4,714 6,561

SUB-TOTAL 71,443 28,001 72,959 32,480 84,735 36,612 101,247 35,723 146,504 74,872COMMUNITY HEALTHHealth Policy, Mgmt & Eval 399 3,662 683 2,724 1,135 6,824 1,368 5,476 1,819 6,660Public Health Sciences 6,430 7,828 10,206 7,540 10,410 7,789 11,265 7,563 13,916 10,098

SUB-TOTAL 6,829 11,490 10,889 10,264 11,545 14,613 12,633 13,039 15,735 16,758CLINICALAnesthesia 1,978 406 2,592 494 2,834 338 3,481 393 3,561 700Family & Community Medicine 1,203 18 1,096 0 1,463 108 1,781 204 4,010 785Lab. Medicine & Pathobiology 14,811 3,011 15,408 3,722 18,246 4,852 20,404 6,675 17,707 7,691Medical Imaging 3,251 40 3,904 0 3,400 4 3,174 5 7,325 15Medicine 52,069 10,084 52,401 8,839 64,308 10,081 71,622 10,798 88,744 16,133Obstetrics & Gynaecology 4,173 0 3,835 0 5,543 0 5,820 0 7,123 1Occupational Therapy 550 289 470 470 602 764 432 891 604 813Ophthalmology And Vision Sci 2,081 927 1,612 1,067 1,964 1,072 3,087 1,106 3,448 1,090Otolaryngology 734 0 476 0 471 0 487 0 426 21Paediatrics 16,945 2 19,677 4 21,417 14 20,531 33 20,562 201Physical Therapy 1,053 163 1,484 235 982 573 991 618 1,321 767Psychiatry 21,480 66 19,724 1,180 16,199 554 20,394 486 23,722 1,437Radiation Oncology 2,610 4 3,143 685 3,438 5 7,607 5 7,269 28Speech-Language Pathology 62 559 151 431 60 518 46 706 433 1,066Surgery 19,177 734 18,821 840 15,277 660 23,932 807 24,686 885

SUB-TOTAL 142,177 16,303 144,794 17,967 156,204 19,543 183,789 22,727 210,941 31,633Other 2 6,409 947 15,324 1,531 26,139 1,512 21,932 12,556 9,868 1,786

TOTAL 226,858 56,741 243,966 62,242 278,623 72,280 319,601 84,045 383,048 125,049CFI/OIT 3 15,869 8,165 37,174 2,665 27,286 7,900 41,551 18,913 19,187 18,141Indirect Costs 4 12,946 1,160

GRAND TOTAL 242,727 64,906 281,140 64,907 305,909 80,180 361,152 102,958 415,181 144,350FISCAL YEAR TOTAL 5

1 Defunct Depertment of Anatomy and Cell Biology in 2001/02

5 Grand Total and Fiscal Year Total for FYs 2003-2004, 2004-2005 INCLUDE Indirect Costs

4 Federal Indirect Costs Program awarded to Faculty of Medicine and affiliated hospit


5-year Departmental Research Funding in THOUSANDS of DollarsBy Campus vs Affiliated Hospital Location

FY 2000-01 FY 2001-02 FY 2002-03 FY 2003-04 FY 2004-05

386,091346,047309,916

2 Includes global research budget of the Institute for Clinical Evaluative Sciences, Structural Genomics Consortium, SARS Laboratory, UofT Equipment maintenance grants, clinical trial grants at the Sunnybrook Hospital/University of Toronto Clinic, ORDCF grants, Ontario Genomics Institute grants, undergraduate summer studentship awards, graduate studentship awards for independent study and Health Communication Research Laboratory in the Faculty of Medicine.3 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Site of SWCHSC, University of Toronto and the University Health Network

559,532476,688

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Department All Locations Campus Baycrest Bloorview CAMH HSC MSH SMH SWCHSC TRI UHN OtherBASICBBDMR 47,242 44,760 0 0 7 0 0 0 0 0 2,475 0Biochemistry 20,754 4,479 0 0 0 5,955 6,299 0 0 0 4,020 0Biomat & Biomed Eng 2,157 1,170 0 290 0 0 350 0 0 0 347 0Immunology 10,745 1,591 0 0 0 1,476 693 0 2,830 0 4,154 0Medical Biophysics 74,422 1,629 42 0 0 1,175 0 0 34,003 0 37,574 0Medical Genetics & Microbiology 45,709 8,555 0 0 0 8,884 27,107 0 41 0 1,123 0Nutritional Sciences 5,016 3,410 111 0 0 54 0 1,442 0 0 0 0Pharmacology 4,056 2,717 0 0 806 201 0 0 291 0 42 0Physiology 11,275 6,561 0 0 1 2,377 28 207 0 0 2,070 30

SUB-TOTAL 221,374 74,872 153 290 814 20,121 34,477 1,649 37,165 0 51,805 30COMMUNITY HEALTHHealth Policy, Mgmt & Eval 8,478 6,660 22 0 60 209 0 0 572 219 622 115Public Health Sciences 24,014 10,098 0 0 5,841 1,110 2,121 1,110 1,976 45 572 1,141

SUB-TOTAL 32,493 16,758 22 0 5,901 1,319 2,121 1,110 2,548 264 1,195 1,256CLINICALAnesthesia 4,262 700 0 0 0 550 170 1,087 265 0 1,490 0Family & Community Medicine 4,796 785 0 0 1,196 0 1,285 417 562 0 284 266Lab. Medicine & Pathobiology 25,398 7,691 0 0 0 3,584 5,306 1,032 2,363 0 5,321 102Medical Imaging 7,340 15 0 0 0 136 233 0 5,510 0 1,446 0Medicine 104,876 16,133 2,081 16 77 191 9,639 24,710 14,722 518 36,780 12Obstetrics & Gynaecology 7,125 1 0 0 0 1 3,892 141 3,010 0 79 0Occupational Therapy 1,418 813 0 89 0 0 0 255 0 260 0 0Ophthalmology And Vision Sci 4,537 1,090 0 0 0 765 0 626 15 0 2,042 0Otolaryngology 447 21 0 0 0 283 0 13 130 0 0 0Paediatrics 20,763 201 0 48 0 19,978 20 2 515 0 0 0Physical Therapy 2,089 767 0 48 0 2 79 6 700 407 60 19Psychiatry 25,159 1,437 569 0 16,110 1,731 281 607 1,049 102 3,197 77Radiation Oncology 7,297 28 0 0 0 0 0 0 2,607 0 4,663 0Speech-Language Pathology 1,500 1,066 0 0 0 20 0 0 345 69 0 0Surgery 25,571 885 0 49 43 4,825 2,977 1,790 4,355 0 10,648 0

SUB-TOTAL 242,577 31,634 2,650 250 17,425 32,065 23,882 30,684 36,148 1,355 66,008 476Other 11,654 1,786 0 117 0 1,666 2,032 0 1,569 3,018 1,468 0CFI/OIT 37,328 18,141 0 0 0 1,377 2,617 265 11,149 0 3,779 0Indirect Costs 1 1,160 1,160 0 0 0 0 0 0 0 0 0 0

GRAND TOTAL 546,586 144,350 2,824 656 24,140 56,549 65,129 33,708 88,578 4,637 124,254 1,7621 Excludes a total of $12,946,032 from the Federal Indirect Costs Program awarded to affiliate hospitals.

for the year 2004/05 in THOUSANDS of dollars


Department Research Funding vs LocationAll Sponsors

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HOSPITAL Total CIHR NSERC NCICHLTH CAN MOH HSFO/C SSHRC INDUS OTHER

# of Awards

Baycrest Centre for Geriatric Care 2,824 1,429 0 0 0 0 367 194 0 833 31Bloowview MacMillab Children's Centre 656 84 60 0 0 40 0 0 0 471 18Centre for Addiction and Mental Health 24,140 6,408 12 81 601 3,743 62 67 5,602 7,563 239Hospital for Sick Children 55,171 21,805 434 2,595 10 0 2,115 71 2,787 25,353 896Mount Sinai Hospital 62,284 17,274 674 2,944 0 1,506 403 0 5,185 34,298 479St. Michael's Hospital 34,379 4,923 106 61 93 12 1,198 12 7,816 20,158 675SWCHSC

Sunnybrook site 64,826 10,390 266 3,407 25 617 1,344 10 3,512 45,254 426 Orthopaeic & Arthritic site 0 0 0 0 0 0 0 0 0 0 0 Women's College site 12,604 3,609 0 702 250 1,048 53 35 400 6,507 65Toronto Rehabilitation Institute 4,637 444 0 0 0 3,000 0 0 64 1,130 35University Health Network 120,475 23,585 918 14,679 68 1,535 4,016 0 8,823 66,852 1,430Other Hospitals 1 1,660 650 0 0 0 303 0 20 51 635 39

SUB-TOTAL 383,655 90,601 2,470 24,469 1,047 11,804 9,558 409 34,240 209,054 4,333Other Locations 2 102 0 0 0 0 0 0 0 0 102 1UofT Campus 124,342 31,661 3,515 4,047 473 5,383 2,205 373 3,712 72,974 2,477

TOTAL 508,099 122,262 5,985 28,516 1,520 17,187 11,763 782 37,952 282,130 6,811CFI/OIT 3 37,328 35Indirect Costs 4 1,160 1

GRAND TOTAL 546,587 (x $1000) 6,847

1 Research at non-affilitaed hospitals.2 Research at other locations other than UofT Campus and other hospitals.3 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Site of SWCHSC, University of Toronto and the University Health Network.


Summary of Location Research vs Sponsor (Funding Source) in THOUSANDS of DollarsApril 2004 - March 2005


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DEPARTMENT FY 2000/01 FY 2001/02 FY 2002/03 FY 2003/04 FY 2004/05 2000-2003 2001-2004 2002-2005BASICAnatomy and Cell Biology 1 2,495 N/A N/A N/A N/A N/A N/A N/ABBDMR 7,541 8,450 11,217 11,681 47,242 22.4 18.4 154.3Biochemistry 7,525 9,306 10,328 9,585 20,754 17.3 1.9 54.7Biomat & Biomed Eng 2,142 1,958 1,801 2,116 2,157 -8.3 4.7 9.7Immunology 6,071 5,586 6,376 7,011 10,745 3.1 12.0 31.6Medical Biophysics 32,835 29,752 38,310 46,839 74,422 9.7 25.5 40.6Medical Genetics & Microbiology 25,693 33,014 35,051 40,043 45,709 17.3 10.2 14.2Nutritional Sciences 3,907 3,721 3,569 4,554 5,016 -4.4 11.8 18.9Pharmacology 5,065 3,329 3,662 3,925 4,056 -12.1 8.6 5.3Physiology 8,452 10,323 11,032 11,215 11,275 14.5 4.3 1.1

SUB-TOTAL 101,725 105,438 121,347 136,969 221,374 9.4 14.0 37.2COMMUNITY HEALTHHealth Policy, Mgmt & Eval 4,060 3,406 7,959 6,844 8,478 58.8 59.8 4.9Public Health Sciences 14,258 17,746 18,199 18,827 24,014 13.5 3.0 15.5

SUB-TOTAL 18,319 21,152 26,159 25,671 32,493 19.6 62.8 20.4CLINICALAnesthesia 2,384 3,086 3,172 3,874 4,262 16.1 12.5 16.1Family & Community Medicine 1,220 1,096 1,571 1,985 4,796 16.6 34.8 84.0Lab. Medicine & Pathobiology 17,822 19,130 23,098 27,078 25,398 14.0 19.0 5.5Medical Imaging 3,291 3,904 3,403 3,179 7,340 2.9 -9.7 62.2Medicine 62,153 61,239 74,389 82,421 104,876 10.0 16.1 19.0Obstetrics & Gynaecology 4,173 3,835 5,543 5,820 7,125 18.2 24.8 13.7Occupational Therapy 840 940 1,366 1,323 1,418 28.6 21.1 2.0Ophthalmology And Vision Sci 3,008 2,680 3,036 4,193 4,537 1.2 25.7 23.2Otolaryngology 734 476 471 487 447 -18.1 1.1 -2.3Paediatrics 16,947 19,682 21,431 20,563 20,763 12.5 2.4 -1.5Physical Therapy 1,216 1,719 1,555 1,609 2,089 15.9 -3.0 16.6Psychiatry 21,546 20,904 16,753 20,880 25,159 -11.4 2.4 22.6Radiation Oncology 2,614 3,828 3,443 7,612 7,297 18.2 55.5 58.5Speech-Language Pathology 621 582 578 752 1,500 -3.5 14.8 64.8Surgery 19,912 19,661 15,938 24,738 25,571 -10.1 18.1 29.3

SUB-TOTAL 158,482 162,762 175,747 206,515 242,577 5.3 12.7 17.5Other 2 7,357 16,856 27,652 34,489 11,654 96.6 44.4 -20.7

TOTAL 285,883 306,208 350,905 403,644 508,098 10.9 14.8 20.5CFI/OIT 3 24,033 39,839 35,186 60,464 37,328 27.0 30.1 16.8Indirect Costs 4 776 1,160

GRAND TOTAL 309,916 346,047 386,091 464,107 546,586 11.6 15.9 19.0

1 Defunct Depertment of Anatomy and Cell Biology in 2001/022 Includes global research budget of the Institute for Clinical Evaluative Sciences, Structural Genomics Consortium, SARS Laboratory, UofT Equipment maintenance grants, clinical trial grants at the Sunnybrook Hospital/University of Toronto Clinic, ORDCF grants, Ontario Genomics Institute grants, undergraduate summer studentship awards, graduate studentship awards for independent study and Health Communication Research Laboratory in the Faculty of Medicine.3 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Site of SWCHSC, University of Toronto and the University Health Network.

Table 2AFACULTY OF MEDICINE - UNIVERSITY OF TORONTOResearch Funding 3-year Averages By Department

for the periods: 2000-03, 2001-04, 2002-05Research Funding in THOUSANDS of dollars Three-Year Average Annual % Change1


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FY 2000-01 FY 2001-02 FY 2002-03 FY 2003-04 FY 2004-05Index alues: 1.00 1.03 1.05 1.08 1.10 2000-2003 2001-2004 2002-2005

DEPARTMENTBASICAnatomy and Cell Biology 1 2,495 N/A N/A N/A N/A N/A N/A N/ABBDMR 7,541 8,204 10,683 10,816 42,947 19.5 15.7 149.2Biochemistry 7,525 9,035 9,836 8,875 18,867 14.5 -0.4 51.4Biomat & Biomed Eng 2,142 1,901 1,716 1,959 1,961 -10.5 2.2 7.1Immunology 6,071 5,423 6,073 6,492 9,768 0.7 9.4 28.7Medical Biophysics 32,835 28,886 36,486 43,370 67,656 7.1 22.6 37.4Medical Genetics & Microbiology 25,693 32,052 33,382 37,076 41,553 14.5 7.6 11.6Nutritional Sciences 3,907 3,613 3,399 4,217 4,560 -6.7 9.1 16.1Pharmacology 5,065 3,232 3,487 3,634 3,687 -14.1 6.1 2.8Physiology 8,452 10,023 10,507 10,384 10,250 11.7 1.8 -1.2


SUB-TOTAL 18,318 20,536 24,913 23,770 29,539 16.7 57.0 15.5CLINICALAnesthesia 2,384 2,996 3,021 3,587 3,874 13.2 9.8 13.4Family & Community Medicine 1,220 1,064 1,496 1,838 4,360 13.9 31.7 80.0Lab. Medicine & Pathobiology 17,822 18,573 21,998 25,072 23,089 11.3 16.2 3.0Medical Imaging 3,291 3,791 3,241 2,943 6,673 0.3 -11.8 58.8Medicine 62,153 59,456 70,847 76,315 95,342 7.4 13.4 16.3Obstetrics & Gynaecology 4,173 3,723 5,279 5,389 6,477 15.5 21.9 11.1Occupational Therapy 840 913 1,301 1,225 1,289 25.6 18.3 -0.3Ophthalmology And Vision Sci 3,008 2,602 2,892 3,882 4,125 -1.2 22.7 20.2Otolaryngology 734 463 448 451 407 -20.0 -1.3 -4.6Paediatrics 16,947 19,109 20,410 19,040 18,876 9.8 0.0 -3.8Physical Therapy 1,216 1,669 1,481 1,490 1,899 13.0 -5.3 14.0Psychiatry 21,546 20,295 15,955 19,334 22,872 -13.6 -0.1 19.7Radiation Oncology 2,614 3,717 3,279 7,049 6,634 15.2 51.6 54.5Speech-Language Pathology 621 565 550 697 1,363 -5.8 12.0 61.1Surgery 19,912 19,089 15,179 22,906 23,246 -12.3 15.2 26.2

SUB-TOTAL 158,481 158,025 167,377 191,218 220,526 2.8 10.1 14.8Other 2 7,357 16,365 26,335 31,934 10,595 91.7 41.1 -22.8


GRAND TOTAL 309,915 335,974 367,704 429,730 496,897 8.9 13.2 16.21 Defunct Depertment of Anatomy and Cell Biology in 2001/022 Includes global research budget of the Institute for Clinical Evaluative Sciences, Structural Genomics Consortium, SARS Laboratory, UofT Equipment maintenance grants, clinical trial grants at the Sunnybrook Hospital/University of Toronto Clinic, ORDCF grants, Ontario Genomics Institute grants, undergraduate summer studentship awards, graduate studentship awards for independent study and Health Communication Research Laboratory in the Faculty of Medicine.3 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Site of SWCHSC, University of Toronto and the University Health Network.4 Federal Indirect Costs Program awarded to Faculty of Medicine

Table 2BFACULTY OF MEDICINE - UNIVERSITY OF TORONTO

Research Funding 3-year Averages By Department in 1999 CONSTANT Dollarsfor the periods: 2000-03, 2001-04, 2002-05

Research Funding in THOUSANDS of dollars

Three-Year Average Annual % Change 1

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Department All Locations Campus Baycrest Bloorview CAMH HSC MSH SMH SWCHSC TRI UHN OtherBASICBBDMR 5,249 5,249 0 0 0 0 0 0 0 0 0 0Biochemistry 6,036 2,220 0 0 0 3,289 235 0 0 0 293 0Biomat & Biomed Eng 800 598 0 145 0 0 0 0 0 0 58 0Immunology 4,047 896 0 0 0 645 371 0 933 0 1,201 0Medical Biophysics 8,770 816 0 0 0 355 0 0 2,214 0 5,386 0Medical Genetics & Microbiology 16,180 4,102 0 0 0 4,580 7,157 0 41 0 301 0Nutritional Sciences 1,872 997 111 0 0 35 0 729 0 0 0 0Pharmacology 1,596 1,556 0 0 0 0 0 0 28 0 12 0Physiology 5,585 3,560 0 0 0 776 0 100 0 0 1,149 0SUB-TOTAL 50,135 19,994 111 145 0 9,680 7,763 829 3,216 0 8,400 0COMMUNITY HEALTHHealth Policy, Mgmt & Eval 2,893 1,767 22 0 0 158 0 0 434 0 473 39Public Health Sciences 8,907 4,352 0 0 1,396 525 1,427 0 521 45 79 562SUB-TOTAL 11,800 6,119 22 0 1,396 683 1,427 0 955 45 552 601CLINICALAnesthesia 1,233 249 0 0 0 520 0 65 197 0 202 0Family & Community Medicine 1,314 298 0 0 248 0 249 159 358 0 0 0Lab. Medicine & Pathobiology 7,651 2,296 0 0 0 1,368 1,029 149 1,125 0 1,684 0Medical Imaging 568 0 0 0 0 136 0 0 230 0 202 0Medicine 24,959 4,168 1,134 0 0 94 3,307 3,321 3,865 0 9,069 0Obstetrics & Gynaecology 5,036 0 0 0 0 0 2,399 0 2,637 0 0 0Occupational Therapy 216 157 0 0 0 0 0 59 0 0 0 0Ophthalmology And Vision Sci 750 0 0 0 0 225 0 7 0 0 517 0Otolaryngology 272 21 0 0 0 157 0 0 94 0 0 0Paediatrics 6,711 73 0 0 0 6,244 0 0 393 0 0 0Physical Therapy 682 253 0 0 0 0 66 0 94 268 0 0Psychiatry 8,649 1,216 357 0 4,800 695 175 97 209 62 970 69Radiation Oncology 553 0 0 0 0 0 0 0 117 0 435 0Speech-Language Pathology 325 256 0 0 0 0 0 0 0 69 0 0Surgery 6,787 202 0 0 43 1,508 1,482 258 820 0 2,474 0SUB-TOTAL 65,706 9,189 1,491 0 5,091 10,947 8,707 4,115 10,139 399 15,553 69Other hospitals 1,391 341 0 0 0 1,000 50 0 0 0 0 0GRAND TOTAL 129,032 35,643 1,624 145 6,487 22,310 17,947 4,944 14,310 444 24,505 670

for the years 2002/03, 2003/04 and 2004/05 in THOUSANDS of Dollars

Table 3AFACULTY OF MEDICINE - UNIVERSITY OF TORONTO

Three-year AVERAGE of Department Research Funding vs LocationAll Sponsors

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Department All Locations Campus Baycrest Bloorview CAMH HSC MSH SMH SWCHSC TRI UHN OtherBASICBBDMR 3,572 3,542 0 0 0 0 0 0 0 0 30 0Biochemistry 6,250 2,180 0 0 0 3,707 221 0 0 0 142 0Biomat & Biomed Eng 296 136 0 88 0 0 72 0 0 0 0 0Immunology 3,512 517 0 0 0 868 524 0 824 0 778 0Medical Biophysics 8,168 259 0 0 0 195 0 0 2,110 0 5,604 0Medical Genetics & Microbiology 15,440 4,222 0 0 0 4,747 6,333 0 0 0 138 0Nutritional Sciences 1,830 1,095 84 0 0 51 0 590 11 0 0 0Pharmacology 1,868 1,459 0 0 135 120 0 0 153 0 0 0Physiology 7,171 4,694 0 0 0 958 0 104 0 0 1,414 0SUB-TOTAL 48,107 18,104 84 88 135 10,646 7,150 694 3,098 0 8,106 0COMMUNITY HEALTHHealth Policy, Mgmt & Eval 1,699 1,159 11 0 78 114 0 0 132 13 179 14Public Health Sciences 6,475 3,084 0 0 1,071 304 1,306 22 392 0 274 23SUB-TOTAL 8,174 4,243 11 0 1,149 418 1,306 22 524 13 453 37CLINICALAnesthesia 1,067 245 0 0 0 221 0 82 177 0 341 0Family & Community Medicine 698 82 0 0 81 0 138 130 266 0 0 0Lab. Medicine & Pathobiology 7,138 1,971 0 0 0 1,646 1,220 111 717 0 1,473 0Medical Imaging 482 0 0 0 0 41 0 0 270 0 171 0Medicine 20,024 3,584 1,170 0 100 80 1,295 2,423 3,169 0 8,202 0Obstetrics & Gynaecology 3,383 0 0 0 0 0 1,914 0 1,466 0 3 0Occupational Therapy 173 83 0 15 0 0 0 75 0 0 0 0Ophthalmology And Vision Sci 561 0 0 0 0 214 0 0 0 0 348 0Otolaryngology 267 0 0 0 0 167 0 0 101 0 0 0Paediatrics 6,620 0 0 5 0 6,605 0 0 3 0 7 0Physical Therapy 472 89 0 0 0 0 34 0 180 150 18 0Psychiatry 6,864 231 299 0 4,721 654 96 16 196 13 615 23Radiation Oncology 443 0 0 0 0 0 0 0 213 0 230 0Speech-Language Pathology 220 202 2 0 0 0 0 0 0 0 15 0Surgery 6,039 148 0 0 0 1,373 1,520 43 826 0 2,128 0SUB-TOTAL 54,451 6,635 1,471 20 4,902 11,001 6,217 2,880 7,584 163 13,551 23Other hospitals 1,790 672 5 0 0 1,000 13 100 0 0 0 0GRAND TOTAL 112,522 29,654 1,571 108 6,186 23,065 14,686 3,696 11,206 176 22,110 60

for the years 2002/03, 2003/04 and 2004/05 in THOUSANDS of Dollars


Three-year AVERAGE of Department Research Funding vs LocationTri-Council (CIHR / NSERC / SSHRC) only

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HOSPITAL FY 2000/01 FY 2001/02 FY 2002/03 FY 2003/04 FY 2004/05 2000-2003 2001-2004 2002-2005Baycrest Centre for Geriatric Care 1,806 1,880 3,443 3,050 2,824 43.6 35.9 -9.4Bloorview MacMillab Children's Centre 1,868 1,612 1,568 1,438 656 -8.2 -5.5 -31.3Centre for Addiction and Mental Health 19,146 18,540 17,358 19,961 24,140 -4.8 4.3 18.0Hospital for Sick Children 50,746 55,532 53,579 59,445 55,171 3.0 3.7 1.9Mount Sinai Hospital 28,356 34,662 45,246 52,206 62,284 26.4 23.0 17.3St. Michael's Hospital 15,604 24,037 26,633 24,640 34,379 32.4 1.7 16.0SWCHSC Sunnybrook site 32,639 33,943 37,607 44,675 64,826 7.4 14.8 32.0 Orthopaeic & Arthritic site 805 524 257 112 0 -42.9 -53.8 -56.6 Women's College site 5,563 3,576 3,821 6,830 12,604 -14.4 42.8 81.6Toronto Rehabilitation Institute 0.0 -9.8 162.4University Health Network 67,688 65,063 85,853 106,129 120,475 14.0 27.8 18.6Other Hospitals 2 2,378 1,061 408 3,381 1,660 -58.5 333.9 339.3

SUB-TOTAL 226,599 241,731 277,017 322,921 383,655 10.6 15.6 17.7Other Locations 3 580 194 129 59 102 -50.1 -44.1 9.4UofT Campus 59,024 62,048 72,152 84,045 124,342 10.7 16.4 32.2


GRAND TOTAL 6 310,237 343,812 384,483 468,264 546,586 11.3 16.8 19.3

1 Percentage represents the annual changes in funding averaged over each three year period.2 Non-affiliated hospitals and Institute of Work and Health3 Research at locations other than U of T campus or other affiliated/non-affiliated hospitals.4 The CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, Sunnybrook Site of SWCHSC, University of Toronto and the University Health Network.5 Federal Indirect Costs Program awarded to Faculty of Medicine6 Excludes Federal Indirect Costs Program awarded to affiliate hospitals.


Research Funding 3-year Averages By Location of Researchfor the periods: 2000-03, 2001-04, 2002-05

Three-Year Average Annual % Change1Research Funding in THOUSANDS of dollars

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HOSPITALBaycrest Centre for Geriatric Care 1,806 1,825 3,279 2,824 2,567 40.4 32.9 -11.5Bloorview MacMillab Children's Centre 1,868 1,565 1,494 1,332 596 -10.4 -7.7 -33.0Centre for Addiction and Mental Health 19,146 18,000 16,531 18,483 21,945 -7.1 1.8 15.3Hospital for Sick Children 50,746 53,915 51,028 55,042 50,156 0.4 1.3 -0.5Mount Sinai Hospital 28,356 33,652 43,092 48,339 56,622 23.4 20.1 14.7St. Michael's Hospital 15,604 23,337 25,365 22,815 31,253 29.1 -0.7 13.5SWCHSC Sunnybrook site 32,639 32,954 35,816 41,366 58,932 4.8 12.1 29.0 Orthopaeic & Arthritic site 805 509 245 103 0 -44.3 -54.8 -57.8 Women's College site 5,563 3,472 3,639 6,324 11,458 -16.4 39.3 77.5Toronto Rehabilitation Institute 1,262 1,184 976 4,215 -6.2 -11.9 157.2University Health Network 67,688 63,168 81,765 98,267 109,523 11.4 24.8 15.8Other Hospitals 2 2,378 1,030 388 3,130 1,509 -59.5 322.0 327.3

SUB-TOTAL 226,599 234,690 263,826 299,001 348,777 8.0 12.9 15.0Other Locations 3 580 189 123 54 92 -51.3 -45.4 7.2UofT Campus 59,024 60,241 68,716 77,819 113,038 8.1 13.7 29.3

TOTAL 286,203 295,119 332,665 376,874 461,908 7.9 13.0 17.9CFI/OIT 4 24,033 38,679 33,510 55,985 33,934 23.8 26.9 13.8

718 1,054GRAND TOTAL 310,237 333,798 366,175 433,577 496,896 8.6 14.1 16.5

1 Percentage represents the annual changes in funding averaged over each three year period.2 Non-affiliated hospitals and Institute of Work and Health3 Research at locations other than U of T campus or other affiliated/non-affiliated hospitals.

Three-Year Average Annual % Change1



Research Funding 3-year Averages By Location of Research in 2000 CONSTANT Dollarsfor the periods: 2000-03, 2001-04, 2002-05

4 The CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, Sunnybrook Site of SWCHSC, University of Toronto and the University Health Network.

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SOURCE FY 1997-98 % FY 1998-99 % FY 1999-00 % FY 2000-01 % FY 2001-02 % FY 2002-03 % FY 2003-04 % FY 2004-05 %FEDERAL GOV.Federal Canada 51,665 24.5 62,620 26.9 70,101 28.0 89,970 31.4 109,557 35.8 131,170 37.4 144,361 35.5 186,328 36.7Federal U.S. 9,289 4.4 14,039 6.0 12,202 4.9 14,617 5.1 20,047 6.5 14,727 4.2 19,166 4.7 17,013 3.3Federal Other 112 0.1 118 0.1 182 0.1 14 0.0 0 0.0 0 0.0 0 0.0 0 0.0Sub-Total 61,066 29.0 76,777 33.0 82,485 33.0 104,601 36.5 129,603 42.3 145,898 41.6 163,528 40.2 203,341 40.0PROVINCIAL GOV.Provincial Canada 30,272 14.4 27,135 11.7 37,987 15.2 41,071 14.4 45,277 14.8 41,085 11.7 61,892 15.2 93,380 18.4Sub-Total 30,272 14.4 27,135 11.7 37,987 15.2 41,071 14.4 45,277 14.8 41,085 11.7 61,892 15.2 93,380 18.4LOCAL SOURCESLocal 7,068 3.4 8,746 3.8 7,265 2.9 8,441 2.9 10,617 3.5 15,339 4.4 18,640 4.6 26,695 5.3Internal Univ/Hosp 6,853 3.2 7,299 3.1 7,952 3.2 10,424 3.6 10,738 3.5 12,722 3.6 12,550 3.1 13,836 2.7Sub-Total 13,920 6.6 16,045 6.9 15,216 6.1 18,866 6.5 21,355 7.0 28,061 8.0 31,190 7.7 40,531 8.0INDUSTRYCanadian Industry 28,648 13.6 26,262 11.3 29,515 11.8 31,478 11.0 20,815 6.8 22,077 6.3 19,731 4.8 25,219 5.0U.S. Industry 9,324 4.4 10,975 4.7 9,195 3.7 8,555 3.0 7,612 2.5 13,111 3.7 14,515 3.6 10,297 2.0Other Foreign Ind. 1,984 0.9 1,804 0.8 1,982 0.8 1,927 0.7 1,478 0.5 1,138 0.3 11,138 2.7 2,434 0.5Sub-Total 39,957 18.9 39,040 16.8 40,692 16.3 41,960 14.7 29,905 9.8 36,327 10.3 45,384 11.1 37,950 7.5NOT-FOR-PROFITCanadian Charity 35,332 16.8 39,849 17.1 40,620 16.2 43,820 15.3 46,403 15.2 60,666 17.3 65,461 16.1 73,970 14.6Provincial Charity 10,133 4.8 9,614 4.1 10,571 4.2 12,533 4.4 12,665 4.1 15,875 4.5 14,746 3.6 16,792 3.3U.S. Charity 3,167 1.5 4,175 1.8 7,022 2.8 6,145 2.1 7,490 2.4 7,066 2.0 8,449 2.1 8,949 1.8Other Foreign Charity 838 0.4 981 0.4 1,252 0.5 1,779 0.6 1,925 0.6 1,550 0.4 1,675 0.4 432 0.1Sub-Total 49,470 23.5 54,619 23.4 59,464 23.7 64,277 22.4 68,482 22.3 85,157 24.2 90,330 22.2 100,142 19.8OTHEROther Canadian Inst. 1,639 0.8 938 0.4 2,402 1.0 2,905 1.0 2,333 0.8 1,935 0.6 1,899 0.5 5,057 1.0U.S. Institutions 1,891 0.9 2,366 1.0 2,069 0.8 2,161 0.8 1,840 0.6 2,337 0.7 1,789 0.4 8,018 1.6Other Foreign Inst. 454 0.2 113 0.0 153 0.1 79 0.0 231 0.1 327 0.1 248 0.1 205 0.0Sub-Total 3,984 1.9 3,416 1.4 4,624 1.9 5,146 1.8 4,404 1.5 4,600 1.4 3,936 1.0 13,281 2.6MISCELLANEOUSVarious Sponsors 12,224 5.8 15,869 6.8 9,791 3.9 10,283 3.6 7,181 2.3 9,769 2.8 10,764 2.6 19,473 3.8Sub-Total 12,224 5.8 15,869 6.8 9,791 3.9 10,283 3.6 7,181 2.3 9,769 2.8 10,764 2.6 19,473 3.8TOTAL 210,892 100 232,902 100 250,259 100 286,203 100 306,208 100 350,896 100 407,024 100 508,098 100CFI/OIT1 24,033 39,839 35,186 60,464 37,328Indirect Costs 2 776 1,160GRAND TOTAL 3 210,892 100 232,902 100 250,259 100 310,237 100 346,047 100 386,082 100 468,264 100 546,586 100Fiscal Year values represent THOUSANDS of dollars.1 The CFI and OIT funding represents infrastructure grants from Federal and Provincial sources.

3 2003-2004 value excludes a total of $11,804,786; 2004-2005 value excludes a total of $12,946,032 from the Federal Indirect Costs Program awarded to affiliate hospitals.

2 Federal Indirect Costs Program awarded to Facu


Research Funding By Source in THOUSANDS of Dollars8-year Distribution Profile

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Figure 1FACULTY OF MEDICINE - UNIVERSITY OF TORONTO

Comparison of Research Funding By Sponsor Source: 1987 to 2005

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Dollar Value Number of Grants/Awards

Research GrantsOperating Grants $416,852,587 3334Collaborative Grants $18,470,310 40Individual Group Grants $4,624,959 39Major Equipment $2,488,801 26Maintenance $1,067,234 16Conference Grants $682,962 10Travel Grants $358,045 10Techonology Transfer $366,723 3CRC Infrastructure Fund $3,177,281 25

Sub-Total $448,088,902 3503Personnel AwardsScientist, Career Investigator Awards $6,169,460 76CRC Scientists/Scholar Awards $12,600,000 93Visiting Scientist Awards $0 0Scholarship Awards $5,573,839 101Fellowship Awards $11,403,204 320Studentship Awards 1 $24,262,989 2718

Sub-Total $60,009,492 3308Total- Research and Personnel Awards $508,098,394 6811

CFI/OIT Physical Infrastructure 2 $37,327,772 35Indirect Costs 3 $1,159,725 1

GRAND TOTAL 4 $546,585,891 6847


Research Funding By Type of GrantApril 2004 - March 2005

1 Studentships (both graduate and undergraduate) include direct awards from external sponsoring agencies and internal awards such as: U of T Open Fellowship, Ontario Graduate Scholarship/Fellowships, U of T Life Science Studentships, U of T Tuition Waivers, and U of T Graduate Bursaries.

2 CFI/OIT (Canadian Foundation for Innovation / Ontario Innovation Trust) and OGI (Ontario Genomics Institute) represent physical infrastructure grants to fund: BIRD – Infrastructure for Biochips and Biorobotics, Imaging and Patient Sample Repository; Cardiovascular Gene Therapy Initiative; Imaging Research Centre for Cardiac Intervention; The Toronto Angiogenesis Research Centre; Centre for Research in Neurodegenerative Diseases; The Centre for Health Research; Developing a Data Warehouse for Health Services Research; Mouse Imaging Centre for Canada; Sunnybrook and Women’s College Comprehensive and Multidisciplinary Breast Cancer Research; Centre for Bio-Imaging Facilities; then Functional Imaging Research Network; Toronto Centre for Comparative Models of Human Disease; Oncology Infrastructure Proposal; Centre for the Integrative Biology of Polygenic and Monogenic Disease; Centre on Molecular Pharmacology; HIV/AIDS and TB Research Facility and Centre for Cellular and Biomolecular Research.




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DEPARTMENTPrimary Appt On Campus Off Campus Cross Appt Tenure Appt Tenure

StreamCareer Awards

Pri Appt with Res Funds

Cross Appt with Res

Funds

Stud Awards Supervised by

Pri Appt

PDF and Clin Res Fellows

BASICBBDMR 14 14 0 14 12 1 4 19 2 51 36Biochemistry 34 18 13 31 18 0 16 32 19 26 64Biomat & Biomed Eng 11 9 2 69 3 6 1 10 68 3 6Immunology 28 6 24 34 5 2 5 23 16 55 25Medical Biophysics 69 1 68 59 1 0 16 59 34 349 38Medical Genetics & Microbiology 60 27 33 31 19 5 31 61 21 231 145Nutritional Sciences 25 14 11 15 7 2 2 15 13 99 3Pharmacology 29 15 14 30 8 1 3 19 n/a 13 11Physiology 43 27 16 47 23 0 17 29 42 155 55SUB-TOTAL 313 131 181 330 96 17 95 267 215 982 383COMMUNITY HEALTHHealth Policy, Mgmt & Eval 22 22 0 109 10 4 5 24 64 82 2Public Health Sciences 258 47 211 147 18 6 15 84 3 44 9SUB-TOTAL 280 69 211 256 28 10 20 108 67 126 11CLINICALAnesthesia 253 2 251 5 2 0 4 24 2 34 8Family & Community Medicine 701 0 701 44 1 0 1 25 8 11 0Lab. Medicine & Pathobiology 226 23 187 73 7 4 14 81 60 158 99Medical Imaging 157 2 155 17 1 0 1 13 n/a 19 10Medicine 911 34 806 122 5 1 48 281 n/a 376 125Obstetrics & Gynaecology 140 1 130 44 2 0 4 22 n/a 22 9Occupational Therapy 154 22 132 1 5 2 1 14 1 5 1Ophthalmology And Vision Sci 89 2 87 12 1 0 0 21 3 27 0Otolaryngology 72 0 72 24 1 0 0 5 2 1 16Paediatrics 315 0 315 35 1 0 17 93 0 113 197Physical Therapy 209 22 187 15 6 1 5 12 n/a 112 3Psychiatry 686 0 686 46 2 0 13 118 n/a 90 10Radiation Oncology 113 0 113 6 0 0 2 30 3 n/a 21Speech-Language Pathology 24 11 13 10 6 3 1 10 1 114 0Surgery 301 7 294 58 3 0 15 124 n/a 141 65SUB-TOTAL 4,351 126 4,129 512 43 11 126 873 80 1,223 564TOTAL 4,944 326 4,521 1,098 167 38 241 1,248 362 2,331 958Based on data received from each individual Department


Research Personnel by DepartmentApril 2004 - March 2005

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HOSPITALInvestigators with Research Funding

Investigators with Career Awards

Student Awards Supervised by

Prim Appt

Post-Doctoral and Clinical Research

FellowsBaycrest Centre for Geriatric Care 13 3 8 7Bloorview MacMillan Children's Centre 8 2 1 0Centre for Addiction and Mental Health 82 14 46 42Hospital for Sick Children 207 52 265 289Mount Sinai Hospital 104 22 118 70St. Michael's Hospital 144 15 128 40SWCHSC 46 Sunnybrook site 129 20 108 no breakdown Orthopaeic & Arthritic site 0 0 0 no breakdown Women's College site 39 3 6 no breakdownToronto Rehabilitation Institute 14 1 10 3University Health Network 297 46 554 218SUB-TOTAL 1037 178 1244 715Other LocationsInstitute for Work and Health 11 1 25 2TOTAL 1048 179 1269 717Hospital Post-doc numbers based on data provided by each individual hospital

April 2004 - March 2005


Summary of Research PersonnelLocated at Affiliated Teaching Hospitals

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DEPARTMENT Sq. Meters

BASICAnatomy & Cell Biology n/aBanting and Best Department of Medical Research 3,270Biochemistry 1,910Institute of Biomaterials & Biomedical Engineering 1 63Immunology 827Medical Biophysics n/aMedical Genetics & Microbiology 2,276Nutritional Sciences 1,009Pharmacology 1,633Physiology 1,982

Sub-Total 12,970COMMUNITY HEALTHHealth Policy, Management & Evaluation 218Public Health Sciences 853

Sub-Total 1,071CLINICALAnesthesia n/aFamily & Community Medicine n/aLab. Medicine & Pathobiology 1,447Medical Imaging n/aMedicine 170Obstetrics & Gynaecology n/aOccupational Therapy 652Ophthalmology And Vision Science 563Otolaryngology n/aPaediatrics n/aPhysical Therapy 810Psychiatry n/aRadiation Oncology n/aSpeech-Language Pathology 577Surgery (includes Anatomy Div.) 333

Sub-Total 4,552OTHERBiomedical Communications 69Centre for Research in Neurodegeneratice Disease 1,251Clinical Sciences Division Common Lab Space 3,108Comparative Medicine 2,280Common Research Space 2,150Electron Microscopy Unit 241Heart & Stroke / Richard Lewar Centre for Excellence… 321Rehabilitation Sciences Sector 151Structural genomics Consortium 721

Sub-Total 9,573Total 28,166

Based on a data extracted on: August, 20041 Includes ONLY IBBME research space at the MSB

Table 9

Research Space at the University of Toronto Campus by DepartmentFACULTY OF MEDICINE - UNIVERSITY OF TORONTO



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Income Source Type Description AWARD STIPEND Grand Total

External - Federal Government $5,411,789.38 $5,696,581.91 $11,108,371.29

External - Ontario Government $1,997,301.00 $419,386.80 $2,416,687.80

External - Other $1,633,741.70 $1,634,766.71 $3,268,508.41

External - Unspecified by Hospital $642,061.75 $7,335,142.74 $7,977,204.49

Internal - U of T $9,984,292.11 $1,874,038.64 $11,858,330.75

Grand Total $19,669,185.94 $16,959,916.80 $36,629,102.74

1 Data provided byOffice of the Associate Dean, Graduate and Inter-Faculty Affairs

Type of Funding


Graduate Student Funding (Awards and Stipends) by Income Source Type 1


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Graduate Unit AWARD STIPEND Grand TotalBiochemistry $818,233.13 $1,338,175.94 $2,156,409.07Graduate Department of Rehabilitation Science $472,849.04 $12,534.86 $485,383.90Health Policy, Management & Evaluation $1,261,758.87 $975,886.79 $2,237,645.66Immunology $803,517.47 $469,628.33 $1,273,145.80Institute of Biomaterials & Biomedical Engin. $464,004.72 $433,286.44 $897,291.16Institute of Medical Science $3,888,938.51 $3,868,311.83 $7,757,250.34Laboratory Medicine & Pathobiology $1,458,731.37 $1,739,185.57 $3,197,916.94Medical Biophysics $2,463,416.39 $2,357,221.14 $4,820,637.53Molecular & Medical Genetics $2,500,332.01 $2,301,693.39 $4,802,025.40Nutritional Sciences $561,158.87 $437,779.33 $998,938.20Occupational Health $227,761.53 $0.00 $227,761.53Pharmacology $757,478.18 $1,043,953.95 $1,801,432.13Physical Therapy $406,014.87 $0.00 $406,014.87Physiology $1,192,636.38 $1,409,872.34 $2,602,508.72Public Health Sciences $1,907,053.28 $512,169.26 $2,419,222.54Speech-Language Pathology $485,301.32 $60,217.63 $545,518.95

Grand Total $19,669,185.94 $16,959,916.80 $36,629,102.741 Data provided byOffice of the Associate Dean, Graduate and Inter-Faculty Affairs

Type of Funding


Graduate Student Funding (Awards and Stipends) by Graduate Unit 1


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Administrative Site DescriptionAwards External to

Institution Stipend1Total (not including

OSOTF below)

UofT Fellowship OtherBaycrest/Rotman Institute $0.00 $15,915.00 $15,915.00Bloorview Macmillan Centre $5,000.00 $0.00 $5,000.00Centre for Addiction and Mental Health $93,500.00 $386,766.34 $480,266.34Hospital For Sick Children $854,707.49 $2,440,784.51 $3,295,492.00Institute Of Work & Health $115,000.00 $43,870.00 $158,870.00Mount Sinai Hospital $380,696.95 $1,132,138.30 $1,512,835.25St. Johns Rehab & West Park Hospital $0.00 $7,500.00 $7,500.00St. Michael's Hospital $125,500.00 $474,887.13 $600,387.13Sunnybrook & Women's College Health Science Centre $290,000.00 $799,345.65 $1,089,345.65Toronto Rehabilitation Institute $65,333.33 $80,000.00 $145,333.33University Health Network $1,061,880.96 $3,338,087.40 $4,399,968.36External $646,764.28 $173,500.00 $820,264.28Off Campus Total $0.00 $3,638,383.01 $8,892,794.33 $12,531,177.34University of Toronto $4,091,993.94 $3,711,845.78 $6,046,510.82 $8,067,122.47 $21,917,473.01

Total (not including OSOTF below) $4,091,993.94 $3,711,845.78 $9,684,893.83 $16,959,916.80 $34,448,650.35

OSOTF/Hospital for Sick Children $1,331,684.33OSOTF/Mount Sinai Hospital $359,000.00OSOTF/Princess Margaret Hospital $381,843.37OSOTF/Toronto Rehabilitation Institute $107,924.69

OSOTF Total2 $2,180,452.39 Grand Total $36,629,102.74Notes:1 Stipend from Supervisor's Research Grant (sources Internal or External to the Institution)2 Matched Funding (1/3 Donation from Hospital Foundation; 1/3 Ontario Government; 1/3 University of Toronto 3 Data provided byOffice of the Associate Dean, Graduate and Inter-Faculty Affairs

Awards Internal to Institution


Graduate Student Funding (Awards and Stipends) by Administrative Location and Source 3


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NOTES TO FACULTY OF MEDICINE DEPARTMENTS Summary of Research Funding and Personnel

In this section of the Synopsis, research funding and demographic data is summarized for each Faculty of Medicine department. Total Research Funding Administered by the Department includes grants, contracts and awards received by principal investigators and administered by the Faculty of Medicine during the period April 1, 2004 to March 31, 2005. This total represents direct research grants and does not include funding received to implement or maintain research infrastructure. Total Number of Awards is the number of distinct research projects awarded to primary appointments in the department. The Academic Staff census provides a summary of faculty members by department including: the number of primary or cross departmental appointments, the main research location (on or off campus) of primary appointments, the number of tenured and tenure-stream faculty and the number of investigators who have received a career award. Initial data on academic staffing was obtained from the Human Resources department and forwarded to each Department for review. In instances wherein information submitted by the Department conflicts with the information obtained from Human Resources, the Department values are reported here. The number of faculty in a department (both primary and cross appointment), who are principal investigators on a research grant, is listed. Professores Emeriti holding a research grant are included in this number. The number of Studentship Grant Awards, (graduate and undergraduate) supervised by a primary appointment to the department is listed. The number of Post-Doctoral Research and Clinical Research Fellows, who are research trainees reported by each Department is shown. A summary of Overall Research Objective and Current Major Areas of Research describes the departmental research focus.


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FACULTY OF MEDICINE – UNIVERSITY OF TORONTO ALL DEPARTMENTS: 2004 - 2005 Total Research Funding: $508,098,3961

Total Number of Awards: 6811 Canadian Institutes of Health Research (CIHR) $122,262,702 Natural Sciences and Engineering Research Council (NSERC) $5,985,317 National Cancer Institute of Canada (NCIC) $28,514,912 Health Canada (HLTH CAN) $1,520,359 Ontario Ministry of Health (MOH) $17,187,378 Heart and Stroke Foundation of Ontario/Canada (HSFO/C) $11,763,625 Social Sciences & Humanities Research Council (SSHRC) $782,790 Industry Sources $37,950,466 Other Sources $282,130,847 Total Number of Academic Staff: Primary Appointments 4944 On Campus 326 Off Campus 4521 Cross Appointments 1098 Tenured 167 Tenure-stream 38 Career Awards 241 Primary Appointments with Research Awards 1248 Fellows: Post-Doctoral and Clinical Research Fellows 958 Based on data received from individual Departments

1 Excludes $37,327,772 in physical infrastructure grants awarded by the CFI and OIT to the University of Toronto and its affiliated teaching hospitals; $1,159,725 from the Federal Indirect Costs Programme awarded to the UofT and $12,946,032 awarded to its affiliated teaching hospitals.


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DEPARTMENT: Anesthesia

Total Research Funding: $4,261,541 Academic Staff:

Total Number of Awards: 100 Primary Appointments 253 On Campus 2 Off Campus 251 Cross Appointments 5 CIHR $1,227,304 Tenured 2 NSERC $5,768 Tenure-stream 0 NCIC $0 Career Awards 4 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 24 HSFO/C $128,122 Cross Appointments 2 SSHRC $0 Studentship Awards: Industry $526,986 Supervised by Primary Appt 34 Other Sources $2,373,361 Fellows: Post-Doc. and Clin. 8

Overall Research Objective : To develop the environment and recruit personnel for research of the highest quality necessary for the advancement of knowledge in the areas of interest to Anesthesia. Current Major Areas of Research ::Faculty in the Department of Anesthesia have developed research interests and programs in a number of fields related to pain management and peri-operative care. These include the following major areas, each represented by an identified contact person. Acute Pain C. McCartney 603-5118 [email protected] Ambulatory Anesthesia F. Chung 503-6118 [email protected] Anesthesia mechanisms B. Orser 480-4864 [email protected] Blood Conservation K. Karkouti 340-5164 [email protected] Cardiovascular D. Mazer 864-5825 [email protected] Critical Care B. Kavanagh 813-8019 [email protected] Malignant Hyperthermia J. Loke 340-3128 [email protected] Neuroscience B. Orser 480-4864 [email protected] Obstetrical Management S. Halpern 323-6008 [email protected] Outcomes Research S. Beattie 340-5164 [email protected] Paediatrics M. Crawford 813-7445 [email protected] Pain mechanisms D. Joo 813-7445 [email protected] Regional Anesthesia V. Chan 340-3227 [email protected] Simulation P.Morgan 323,6269 [email protected] V. Naik 864-5071 [email protected] - Text last updated June 2006


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DEPARTMENT: Banting and Best Department of Medical Research


Total Number of Awards: 121 Primary Appointments 14 On Campus 14 Off Campus 0 Cross Appointments 14 CIHR $4,833,555 Tenured 12 NSERC $415,512 Tenure-stream 1 NCIC $996,666 Career Awards 4 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 19 HSFO/C $204,857 Cross Appointments 2 SSHRC $0 Studentship Awards: Industry $1,060,150 Supervised by Primary Appt 51 Other Sources $39,730,873 Fellows: Post-Doc. and Clin. 36

Overall Research Objective : To use proteomics, functional genomics and bioinformatics to achieve a comprehensive view of gene function, cell regulatory pathways and gene/protein networks. To understand the molecular basis of biological disorders. Current Major Areas of Research : • Cell cycle • Control of gene expression • Developmental biology • Functional genomics • Mechanism of action of hormones • Membrane structure and function • Muscle biology • Proteomics • Structural biology - Text last updated June 2006


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DEPARTMENT: Biochemistry


Total Number of Awards: 227 Primary Appointments 34 On Campus 18 Off Campus 13 Cross Appointments 31 CIHR $5,522,744 Tenured 18 NSERC $513,627 Tenure-stream 0 NCIC $993,545 Career Awards 16 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 32 HSFO/C $375,187 Cross Appointments 19 SSHRC $0 Studentship Awards: Industry $220,000 Supervised by Primary Appt 26 Other Sources $13,128,408 Fellows: Post-Doc. and Clin. 64

Overall Research Objective : To advance and disseminate our understanding of the molecular fundamentals of life through first rate research and academic programs. Current Major Areas of Research : • Biomolecular structure and function • Gene expression and development • Membranes and transport • Molecular cell biology • Molecular medicine • Protein folding • Proteomics and Bioinformatics • Signal transduction and regulation - Text last updated June 2006


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DEPARTMENT: Family and Community Medicine


Total Number of Awards: 57 Primary Appointments 701 On Campus 0 Off Campus 701 Cross Appointments 44 CIHR $1,313,773 Tenured 1 NSERC $0 Tenure-stream 0 NCIC $0 Career Awards 1 HLTH CAN $205,604 With Research Funds MOH $1,394,069 Primary Appointments 25 HSFO/C $58,544 Cross Appointments 8 SSHRC $0 Studentship Awards: Industry $804,908 Supervised by Primary Appt 11 Other Sources $1,018,667 Fellows: Post-Doc. and Clin. 0

Overall Research Objective : To undertake a program of applied clinical and health services research within the goal of improving population access to and the quality of primary care in Canada. Current Major Areas of Research : • Evaluating methods of dissemination and uptake of evidence into practice • Improving clinical practice in the areas of prevention, prenatal care, addictions, primary care

genetics, care of the elderly, prescribing and care of people with chronic disabling conditions • Improving population access to primary care - Text last updated June 2006


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DEPARTMENT: Health Policy, Management and Evaluation


Total Number of Awards: 137 Primary Appointments 22 On Campus 22 Off Campus 0 Cross Appointments 109 CIHR $2,741,673 Tenured 10 NSERC $112,900 Tenure-stream 4 NCIC $0 Career Awards 5 HLTH CAN $15,000 With Research Funds MOH $1,347,015 Primary Appointments 24 HSFO/C $0 Cross Appointments 64 SSHRC $38,285 Studentship Awards: Industry $100,690 Supervised by Primary Appt 82 Other Sources $4,122,930 Fellows: Post-Doc. and Clin. 2

Overall Research Objective : To contribute to knowledge, thereby advancing the discipline, improving teaching and improving the theory and practice of health services management and administration and clinical epidemiology. To educate researchers through the M.Sc./Ph.D. program and to foster an appreciation of the methods and application of health services research among graduate students. Current Major Areas of Research : • Clinical evaluative sciences • Financing of health services • Health measurement • Health care improvement • Health performance assessment • Health policy and economics • Organizational research • Outcomes research • Program planning and evaluation - Text last updated June 2006


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DEPARTMENT: Immunology



Overall Research Objective : To achieve a fundamental understanding of molecular and cellular aspects of the immune system towards elucidating mechanisms underlying host-pathogen interactions and disease resistance. Current Major Areas of Research : • Antigen presentation • B-cell/T-cell ontogeny • Biochemistry of antigen receptor and cytokine receptor signalling • Cell adhesion molecules • Gene expression • Gene rearrangement in antigen receptor structures • Generation of diversity • Hybridoma technology • Immune disorder & autoimmunity • Immunity to infectious disease • Immunodeficiencies • Lymphokine synthesis and action • Protein structure/function relationships • Repertoire development • Tolerance: self/non-self discrimination • Transgenic and knockout technology • Tumour immunology • Vaccine development - Text last updated June 2006


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DEPARTMENT: Inst. of Biomaterials & Biomedical Engineering (Faculties of Dentistry, Medicine & Engineering)


Fac of Med primary appointments $2,156,756 Primary Appointments 11 On Campus 9 Total Number of Awards: 28 Off Campus 2 Cross Appointments 69 CIHR $705,356 Tenured 3 NSERC $94,915 Tenure-stream 6 NCIC $0 Career Awards 1 HLTH CAN $0 With Research Funds MOH $34,300 Primary Appointments 10 HSFO/C $0 Cross Appointments 68 SSHRC $0 Studentship Awards: Industry $37,686 Supervised by Primary Appt 3 Other Sources $1,284,499 Fellows: Post-Doc. and Clin. 6

Overall Research Objective : To integrate medicine/life sciences and engineering. To solve problems in the clinical and life sciences through interdisciplinary and collaborative research that involves methods of engineering, physical sciences and mathematics. To provide a novel approach to major problems in the health sciences through exploitation of the tools, expertise and models of engineering. Current Major Areas of Research : • Biomaterials, Tissue Engineering and Regenerative Medicine: Orthopaedic, dental,

cardiovascular and soft tissue biomaterials; stem cell bioengineering and functioal genomics; drug delivery systems, tissue engineering scaffolds, host response and functional integration. Hemodynamics, cellular and tissue biomechanics, cellular engineering

• Neural, Sensory System and Rehabilitation Engineering: Sensory communication, cellular bioelectricity and neuroscience modeling, nerve regeneration, assistive technologies for the young, the elderly and for enhanced mobility, visual field tracking, current density imaging nanotechnology

• Molecular Imaging and Systems Biology: Scanning probe microscopy, quantum dots, genetic circuits, microarray technology development, microfluidics and MEMS, cellular systems modeling

• Engineering in a Clinical Setting: Intensive care, peri-operative technologies, interventional cardiology and radiology, E-health initiatives, clinical engineering

Departmental Web-site is http://www.utoronto.ca/IBBME - Text last updated June 2006

1 IBBME core-appointed faculty are defined as investigators who meet any or all of the following conditions. The Institute a) pays a percentage of the investigator’s salary, b) provides the investigator with research/office space or c) considers the investigator’s participation central to the academic mission of the IBBME. 2Synopsis research funding breakdowns and demographic data contained in this summary are derived from the Medicine Division of IBBME.


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DEPARTMENT: Laboratory Medicine and Pathobiology


Total Number of Awards: 396 Primary Appointments 226 On Campus 23 Off Campus 187 Cross Appointments 73 CIHR $6,964,299 Tenured 7 NSERC $686,664 Tenure-stream 4 NCIC $1,962,068 Career Awards 14 HLTH CAN $0 With Research Funds MOH $196,756 Primary Appointments 81 HSFO/C $1,824,013 Cross Appointments 60 SSHRC $0 Studentship Awards: Industry $3,384,453 Supervised by Primary Appt 158 Other Sources $10,379,791 Fellows: Post-Doc. and Clin. 99

Overall Research Objective : To carry out innovative and high impact, basic, translational and applied research in pathology and laboratory medicine especially as it relates to cellular, biochemical and molecular mechanisms of human disease. Current Major Areas of Research : • Antibiotic resistance • Biotechnology e.g. analytic biochemistry, mass spectometry, genes, and proteins • Bone, joint and connective tissue diseases e.g. arthritis • Cancer e.g. pathogenesis, chemical carcinogenesis, cancer cytogenetics, molecular

diagnostics, tumour markers, molecular genetics; sarcomas, breast, colon, gynecologic and prostate carcinoma; breast cancer

• Developmental biology and pathobiology • Endocrine diseases e.g. pituitary, thyroid, and diabetes • Genomics and proteomics • Immunopathology, transplantation and immunity • Inflammation • Molecular epidemiology of disease transmission • Molecular genetics and clinical genetics e.g. molecular pathogenesis of infectious disease • Neuropathology e.g. neurodegenerative diseases • Regenerative medicine and tissue engineering • Vascular and cardiovascular cell, molecular and developmental pathobiology e.g.

atherosclerosis, ischemic heart disease, lipid disorders, and valvular disease • Medicine Division of IBBME - Text last updated June 2006


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DEPARTMENT: Medical Biophysics


Total Number of Awards: 598 Primary Appointments 69 On Campus 1 Off Campus 68 Cross Appointments 59 CIHR $8,102,298 Tenured 1 NSERC $668,055 Tenure-stream 0 NCIC $10,372,849 Career Awards 16 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 59 HSFO/C $568,408 Cross Appointments 34 SSHRC $0 Studentship Awards: Industry $1,387,834 Supervised by Primary Appt 349 Other Sources $53,322,511 Fellows: Post-Doc. and Clin. 38

Overall Research Objective : To conduct basic and applied research related to human health with an emphasis on cancer. Current Major Areas of Research : • Angiogenesis • Animal models of human disease • Cancer biology • Cardiovascular Research • Developmental Biology • Digital radiography • Drug resistance mechanisms • Experimental therapeutics • Genomics/proteomics applied to medical research • High throughput structural genomics • Immunological tolerance and autoreactivity • Intracellular signalling pathway • Macromolecular electron microscopy • Macromolecular structure and function • Molecular genetics of cancer • Molecular-Immunological mechanisms • NMR imaging • Stem Cells • Ultrasonography

- Text last updated June 2006


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DEPARTMENT: Medical Genetics & Microbiology


Total Number of Awards: 481 Primary Appointments 60 On Campus 27 Off Campus 33 Cross Appointments 31 CIHR $15,126,766 Tenured 19 NSERC $1,053,171 Tenure-stream 5 NCIC $3,906,491 Career Awards 31 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 61 HSFO/C $189,302 Cross Appointments 21 SSHRC $0 Studentship Awards: Industry $714,742 Supervised by Primary Appt 231 Other Sources $24,718,087 Fellows: Post-Doc. and Clin. 145

Overall Research Objective : The mission of the Department of Medical Genetics & Microbiology is to provide world-class research training and education in the broad area of molecular genetics and cell biology, with a focus on four research themes: 1) functional genomics, molecular biology and macromolecular structure; 2) molecular medicine and human genetics; 3) genetics of development and 4) molecular microbiology and virology. Our aims are to: 1. establish internationally competitive research programs in the areas listed above; 2. train future generations of independent scientists. Current Major Areas of Research : • Functional genomics/proteomics, molecular biology, macromolecular structure: - Signal

transduction and cell regulation - Regulation of gene expression - Chromosome dynamics and biology - Model organism genetics and functional genomics - RNA and nucleic acid metabolism - Structural biology (X-ray crystallography, NMR spectroscopy) - Proteomics and bioinformatics

• Molecular medicine and human genetics: - Complex genetic disease and single gene disorders Disease gene mapping and identification - Genome annotation - Cell biology and developmental biology of disease states - Human chromosome structure, function and dynamics - Molecular diagnostics and gene therapy

• Genetics of development: - Worm fly and mouse models of development - Stem cell research and haematopoiesis - Modeling of human genetic disease - Neurogenesis and neurobiology

• Molecular microbiology and virology: - Host-pathogen (viral, bacterial) interaction - Viral and plasmid segregation - Viral RNA transport and processing

Departmental Website: http://www.utoronto.ca/medicalgenetics/ - Text last updated June 2006


31


DEPARTMENT: Medical Imaging


Total Number of Awards: 44 Primary Appointments 157 On Campus 2 Off Campus 155 Cross Appointments 17 CIHR $488,808 Tenured 1 NSERC $79,391 Tenure-stream 0 NCIC $0 Career Awards 1 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 13 HSFO/C $0 Cross Appointments n/a SSHRC $0 Studentship Awards: Industry $278,168 Supervised by Primary Appt 19 Other Sources $6,493,635 Fellows: Post-Doc. and Clin. 10

Overall Research Objective : Characterization of the structure and function of normal and diseased tissue using all modern imaging methods. Physiologically specific imaging at the metabolic, cellular, vascular and tissue level, using MRS, PET, MRI and MEG. Current Major Areas of Research : • Clinical trials of new contrast agents and drugs • Design of new imaging techniques and imaging systems • Integration of imaging data • Magnetic resonance imaging and spectroscopy • MEG and MSI • Minimally invasive diagnosis and therapy • Molecular imaging • Percutaneous and transvascular treatment methods • PET/CT • Picture archival and communications systems (PACS) • Real-time imaging • Tissue characterization by imaging - Text last updated June 2006


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DEPARTMENT: Medicine


Total Number of Awards: 1456 Primary Appointments 911 On Campus 34 Off Campus 806 Cross Appointments 122 CIHR $24,431,583 Tenured 5 NSERC $321,633 Tenure-stream 1 NCIC $4,445,216 Career Awards 48 HLTH CAN $160,628 With Research Funds MOH $2,426,520 Primary Appointments 281 HSFO/C $4,513,940 Cross Appointments n/a SSHRC $205,914 Studentship Awards: Industry $14,771,909 Supervised by Primary Appt 376 Other Sources $53,598,999 Fellows: Post-Doc. and Clin. 125

Overall Research Objective : To achieve excellence and international recognition. Current Major Areas of Research : • Cardiology: vascular biology/coronary disease, congestive heart failure • Clinical Immunology: inflammatory mechanisms in atherosclerosis, systemic inflammatory

response syndrome • Clinical Pharmacology: drug safety • Dermatology: immunodermatology, skin cancer • Emergency Medicine: prehospital care/trauma, inner city health • Endocrinology/Metabolism: diabetes, dyslipidemias and atherosclerosis, bone & mineral

metabolism • Gastroenterology: cellular and molecular mechanisms of inflammation and organ injury,

molecular genetics of gastrointestinal disease, nutritional modulation of immune functions, inflammation and oncogenesis

• General Internal Medicine: clinical epidemiology & health care research,clinical bioethics,medical educational research

• Geriatric Medicine: optimal prescribing of medications for seniors • Hematology: hematopoiesis/malignant hematology/transplantation/cell and gene therapy,

immunohematology, hemostasis-thrombosis,hemoglobinopathies • Infectious Disease: HIV/AIDS, pathogenesis of infectious disease/drug resistance, epidemiology/

institutional infection control • Medical Oncology: genetic predisposition to cancer, molecular markers of cancer, molecular

mechanisms of drug resistance, angiogenesis physiology: bench to bedside • Nephrology: cellular and molecular mechanisms of inflammation and organ injury, membrane

biology and cell signalling, integrative renal physiology: bench to bedside • Neurology: neurodegenerative disease, neuro-ophthalmology, multiple sclerosis, epilepsy • Non-Divisional: molecular medicine, women’s health • Occupational Medicine: occupational and environmental injury • Physiatry: outcome measurement and functional assessment • Respirology: acute lung injury/respiratory failure, asthma/obstructive airway disease, sleep-

disordered breathing • Rheumatology: autoimmune disease and arthritis, immunobiology & clinical outcomes,

osteoporosis, musculoskeletal disease in the community & work force. - Text last updated June 2006


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DEPARTMENT: Nutritional Sciences


Total Number of Awards: 159 Primary Appointments 25 On Campus 14 Off Campus 11 Cross Appointments 15 CIHR $1,252,057 Tenured 7 NSERC $585,261 Tenure-stream 2 NCIC $314,085 Career Awards 2 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 15 HSFO/C $146,224 Cross Appointments 13 SSHRC $35,000 Studentship Awards: Industry $1,170,369 Supervised by Primary Appt 99 Other Sources $1,513,143 Fellows: Post-Doc. and Clin. 3

Overall Research Objective : To advance the health of the population through basic, clinical and community aspects of human nutrition. Current Major Areas of Research : Diet and cancer L.U. Thompson 978-3523 [email protected] M.C. Archer 978-8195 [email protected] Diet and diabetes T.M.S.Wolever 978-5556 [email protected] Diet and heart disease D.J.A. Jenkins 978-4752 [email protected] Diet and brain function C.E.Greenwood 978-4261 [email protected] Diet and bone health W.E.Ward 946-7366 [email protected] Carbohydate and fiber D.J.A. Jenkins 978-4752 [email protected] Metabolism T.M.S.Wolever 978-5556 [email protected] Food intake regulation G.H. Anderson 978-1832 [email protected] Nutrigenomics A.El-Sohemy 946-5776 [email protected] Paediatric nutrition P. Pencharz 813-6176 [email protected] Socio-cultural V.Tarasuk 978-0618 [email protected] & community aspects of nutrition Departmental Web-site is http://www.utoronto.ca/nutrisci/depthome.htm - Text last updated June 2006


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DEPARTMENT: Obstetrics and Gynaecology


Total Number of Awards: 79 Primary Appointments 140 On Campus 1 Off Campus 130 Cross Appointments 44 CIHR $5,035,766 Tenured 2 NSERC $0 Tenure-stream 0 NCIC $37,500 Career Awards 4 HLTH CAN $0 With Research Funds MOH $258,337 Primary Appointments 22 HSFO/C $0 Cross Appointments n/a SSHRC $0 Studentship Awards: Industry $322,739 Supervised by Primary Appt 22 Other Sources $1,470,438 Fellows: Post-Doc. and Clin. 9

Overall Research Objective : To achieve International recognition as a centre of excellence in women’s health research Current Major Areas of Research : • Clinical and basic perinatology • Control of parturition • Gynecologic cancers • Health services and health outcomes • Medical education • Minimally-invasive surgery • Molecular control of early fetal and placental growth • Multicentre perinatal randomized controlled trials • Paediatric and adolescent gynecology • Reproductive biology • Urogynecology and pelvic floor disorders • Developmental origins of adult health and disease - Text last updated June 2006


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DEPARTMENT: Occupational Therapy Total Research Funding: $1,417,715 Academic Staff:

Total Number of Awards: 89 Primary Appointments 154 On Campus 22 Off Campus 132 Cross Appointments 1 CIHR $137,375 Tenured 5 NSERC $13,500 Tenure-stream 2 NCIC $0 Career Awards 1 HLTH CAN $0 With Research Funds MOH $40,000 Primary Appointments 14 HSFO/C $0 Cross Appointments 1 SSHRC $65,046 Studentship Awards: Industry $0 Supervised by Primary Appt 5 Other Sources $1,161,794 Fellows: Post-Doc. and Clin. 1 Overall Research Objective : The Department of Occupational Science and Occupational Therapy will focus its science on advancing the knowledge of occupation and its enablement. The systematic study of daily occupations and their meanings in the lives of people of all ages and abilities will serve to improve the life and well being of individuals, families, groups, communities and societies, breaking through barriers encountered in all aspects of daily living. Current Major Areas of Research :

D. Barker D. Beaton K. Boschen

Fieldwork education and adult rehabilitation Measurement and muskuloskeletal function Independent living, outcome measures, quality of life, environmental influences, social integration and spinal cord injury

D. Cameron Play and playfulness, fieldwork, parenting styles, cognitive strategies in preschoolers A. Carswell T. Chiu

Outcome measures in occupational therapy, dementia care, healthy aging, older adults with chronic conditions Home care service and technology and aging

L. Cockburn Professional education, teaching and curricula development, participatory research, mental health and mental health promotion, history of occupational therapy, transcultural and diversity issues

A. Colantonio J. Davis

Long term outcomes after traumatic head injury, epidemiology of neurological disability, stroke and dementia, and head injury, “support needs of caregivers”, health issues of women with disabilities Work-life balance

D. Dawson Outcomes following acquired brain injury, psychosocial influences on cognition, cognitive rehabilitation, integrating spirtuality into TO curricula

S. Farrow Psychological implications of illness, group process and therapy; inter-professional education A. Fourt Mental health issues and reform, women’s issues J. Freidland Psychosocial adjustment to illness and disability, effects of social support and coping on quality of life of people with

disabilities, history of occupational therapy and rehabilitation S. Friefeld Quality of life in children with disabilities, sensory-motor learning and adaptation D. Hebert M. Iwama

Attention, apraxia, unilateral neglect, neurology, fieldwork Culture and occupation

B. Kirsch Work reintegration of mental health consumers, models of community support in mental health S. Langlois Quality management, evidence-based practice, multiprofessional education P. McKee Orthotic intervention - principles and design, return to work issues for injured workers A. Mihailidis Assistive technology, cognition and dementia, artificial intelligence, ‘smart’ homes for older adults H. Polatajko Occupation, enablement, client-centred practice, children’s developmental coordination disorder, cognitive treatment

approaches S. Rappolt Continuing professional education, return to work, rehabilitation services delivery D. Reid Child/adolescent development, disability and handicap, assistive technology, measurement of visual perception R. Renwick Quality of life for adults with and without disabilities, children and families, person- environment relationship, health

promotion, independent community living P. Rigby

Development and evaluation of occupational therapy practice model and model of child-environment fit during play, development and cost-utility evaluation of assistive technologies

R. Stack Fieldwork education and assessment - Text last updated June 2006


36


DEPARTMENT: Ophthalmology and Vision Sciences


Total Number of Awards: 74 Primary Appointments 89 On Campus 2 Off Campus 87 Cross Appointments 12 CIHR $749,849 Tenured 1 NSERC $0 Tenure-stream 0 NCIC $298,408 Career Awards 0 HLTH CAN $0 With Research Funds MOH $1,067,148 Primary Appointments 21 HSFO/C $20,000 Cross Appointments 3 SSHRC $0 Studentship Awards: Industry $302,947 Supervised by Primary Appt 27 Other Sources $2,099,037 Fellows: Post-Doc. and Clin. 0

Overall Research Objective : To conduct fundamental research on the eye and visual processing and to apply this knowledge to the alleviation of ocular disease and the prevention of blindness. Current Major Areas of Research : • Aviation vision • Cancer of the eye and orbit • Corneal transplantation • Diabetic retinopathy • Eye Bank/corneal external diseases • Eye tracking technology • Facial nerve paresis • Glaucoma: diagnosis and therapeutics • Hereditary retinal degenerations: molecular genetics • Lacrimal investigation • Laser surgery innovation1 • Ocular genetics • Ocular infectious diseases • Ocular therapeutics • Paediatric ophthalmology • Retina • Retinal Imaging • Retinitis pigmentosa • Ultrasound biomicroscopy • Visual electrophysiology and psychophysics - Text last updated June 2006


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DEPARTMENT: Otolaryngology

Total Research Funding: $447,266 Academic Staff:

Total Number of Awards: 11 Primary Appointments 72 On Campus 0 Off Campus 72 Cross Appointments 24 CIHR $250,825 Tenured 1 NSERC $21,000 Tenure-stream 0 NCIC $0 Career Awards 0 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 5 HSFO/C $0 Cross Appointments 2 SSHRC $0 Studentship Awards: Industry $0 Supervised by Primary Appt 1 Other Sources $175,441 Fellows: Post-Doc. and Clin. 16

Overall Research Objective : To further our basic understanding of the inner ear, upper respiratory tract, and disorders of the neck and skull base. Current Major Areas of Research : • Auditory physiology and pathophysiology • Cochlear implants: basic and applied issues • Head and neck oncology: treatment and epidemiology • Hearing loss and associated communication disorders • Laryngeal cancer histopathology • Neonatal hearing loss • Psychoacoustics • Temporal bone histopathology • Upper respiratory tract • Vestibular and oculomotor topics: clinical and basic - Text last updated June 2006


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DEPARTMENT: Paediatrics


Total Number of Awards: 375 Primary Appointments 315 On Campus 0 Off Campus 315 Cross Appointments 35 CIHR $6,657,606 Tenured 1 NSERC $53,020 Tenure-stream 0 NCIC $380,627 Career Awards 17 HLTH CAN $9,990 With Research Funds MOH $0 Primary Appointments 93 HSFO/C $733,030 Cross Appointments 0 SSHRC $0 Studentship Awards: Industry $1,983,189 Supervised by Primary Appt 113 Other Sources $10,945,905 Fellows: Post-Doc. and Clin. 197

Overall Research Objective : To study mechanisms of disease and health maintenance in infants and children utilizing molecular, biochemical and epidemiological methods. Current Major Areas of Research : • Brain and behavioural research • Cancer and blood research • Cardiovascular research • Cell biology • Developmental biology • Genetics and genomic biology • Infection, immunity, injury and repair research • Integrative biology • Metabolic research • Population health science • Structural biology and biochemistry - Text last updated June 2006


39


DEPARTMENT: Pharmacology


Total Number of Awards: 102 Primary Appointments 29 On Campus 15 Off Campus 14 Cross Appointments 30 CIHR $1,500,154 Tenured 8 NSERC $95,967 Tenure-stream 1 NCIC $145,370 Career Awards 31

HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 19 HSFO/C $0 Cross Appointments n/a SSHRC $0 Studentship Awards: Industry $139,350 Supervised by Primary Appt 13 Other Sources $2,175,294 Fellows: Post-Doc. and Clin. 11

Overall Research Objective : To investigate and understand the interaction of chemical compounds with living systems. To strengthen the department through the development of research related to the mechanisms of drug action and toxicity. Current Major Areas of Research : • Behavioural pharmacology and drug addiction • Biochemical and molecular pharmacology • Clinical pharmacology • Drug metabolism and distribution • Drug safety and toxicology • Neuropharmacology and psychopharmacology • Pharmacogenetics • Receptor pharmacology • Second messengers and signal transduction - Text last updated June 2006

1 The number of primary appointments with research funding includes one professor emeritus.


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DEPARTMENT: Physical Therapy


Total Number of Awards: 138 Primary Appointments 209 On Campus 22 Off Campus 187 Cross Appointments 15 CIHR $624,786 Tenured 6 NSERC $56,908 Tenure-stream 1 NCIC $0 Career Awards 5 HLTH CAN $0 With Research Funds MOH $546,160 Primary Appointments 12 HSFO/C $0 Cross Appointments n/a SSHRC $0 Studentship Awards: Industry $0 Supervised by Primary Appt 112 Other Sources $860,690 Fellows: Post-Doc. and Clin. 3

Overall Research Objective : To develop a strong theoretical and scientific base of knowledge in Physical Therapy and Rehabilitation Science. To develop a research focus in areas of impairment, physical capacity, functional and psychosocial aspects of disability and participation. Please visit the research section out web site for more information www.physicaltherapy.utoronto.ca Current Major Areas of Research : • Rehabilitation health services • Return to work strategies • Motor control and neurorehabilitation • Cardiopulmonary rehabilitation • Psychosocial aspects of disabilities and chronic illness • Measurement and therapeutic strategies to enhance activity and participation across

continuum care - Text last updated June 2006


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DEPARTMENT: Physiology


Total Number of Awards: 260 Primary Appointments 43 On Campus 27 Off Campus 16 Cross Appointments 47 CIHR $5,175,188 Tenured 23 NSERC $409,314 Tenure-stream 0 NCIC $0 Career Awards 17 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 29 HSFO/C $1,050,601 Cross Appointments 42 SSHRC $0 Studentship Awards: Industry $80,584 Supervised by Primary Appt 155 Other Sources $4,559,211 Fellows: Post-Doc. and Clin. 55

Overall Research Objective : Key Priorities: a) To expand and enrich four key areas of basic research represented by our Platforms of Research (see below) and to integrate these basic research activities into the clinical and basic research objectives of our sister hospital based research institutions. A “research partnership” is defined as a mutually beneficial collaborative research link which includes sharing of personnel and resources between the Department of Physiology on one hand and another Research unit within the University of Toronto/ Health Care Research community b) An important aspect of our research partnerships is to provide an outstanding environment for postdoctoral and graduate trainees c) An important aspect of our research partnerships is to provide an outstanding environment for the basic science training of clinician scientists d) A key priority of our research efforts is aimed at providing specialized undergraduate teaching to Arts and Sciences students with the objective of attracting the very best candidate for graduate level training in the Faculty of Medicine Key Challenges: a) To develop strategies that define academic and research partnerships between Departmental Research Platforms and other organizations within the University of Toronto/ Health Care Complex b) To expand competitive funding for research and training initiatives involving members of the Department of Physiology and our active research partners c) To recruit top research scientists to the full extent of our fiscal and physical resources and to maintain the Department of Physiology at the leading edge of international research. To maintain and enhance the infrastructure support from sources external to the direct budget of the Department Current Major Areas of Research : The following describes our plans for introduction of Research Platforms with sub-interest groups. Proposed Research Platforms: 1. Cardiovascular & Respiratory Science: http://www.uoftphysiology.com/faculty/programs/divisionDetails.cfm?division=6&from=listing 2. Endocrinology & Diabetes: http://www.uoftphysiology.com/faculty/programs/divisionDetails.cfm?division=5&from=listing 3. Brain & Behaviour: The Neurosciences: http://www.uoftphysiology.com/faculty/programs/divisionDetails.cfm?division=7&from=listing 4. Reproduction and Development: http://www.uoftphysiology.com/faculty/programs/divisionDetails.cfm?division=9&from=listing - Text last updated June 2006


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DEPARTMENT: Psychiatry


Total Number of Awards: 362 Primary Appointments 686 On Campus 0 Off Campus 686 Cross Appointments 46 CIHR $8,541,659 Tenured 2 NSERC $28,832 Tenure-stream 0 NCIC $324,177 Career Awards 13 HLTH CAN $71,511 With Research Funds MOH $417,285 Primary Appointments 118 HSFO/C $410,055 Cross Appointments n/a SSHRC $78,966 Studentship Awards: Industry $5,661,579 Supervised by Primary Appt 90 Other Sources $9,624,780 Fellows: Post-Doc. and Clin. 10

Overall Research Objective: The overarching goals of research in the Department of Psychiatry are to increase our understanding of the determinants of psychiatric illness, the mechanisms which contribute to the development of mental illness, and to develop more effective interventions to reduce the burden of mental illness. Current Major Areas of Research : The Department of Psychiatry supports major research in the fields including schizophrenia, mood disorders, geriatric psychiatry, child psychiatry, forensic psychiatry, psychotherapy, women’s mental health, addictions, neuropsychiatry and psychosomatic medicine. - Text last updated June 2006


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DEPARTMENT: Public Health Sciences


Total Number of Awards: 431 Primary Appointments 258 On Campus 47 Off Campus 211 Cross Appointments 147 CIHR $8,274,521 Tenured 18 NSERC $317,432 Tenure-stream 6 NCIC $1,182,394 Career Awards 15 HLTH CAN $807,626 With Research Funds MOH $5,915,886 Primary Appointments 84 HSFO/C $0 Cross Appointments 3 SSHRC $314,854 Studentship Awards: Industry $181,300 Supervised by Primary Appt 44 Other Sources $7,020,289 Fellows: Post-Doc. and Clin. 9

Overall Research Objective : To be at the forefront of public health, population health and health promotion research internationally. This is accomplished by understanding determinants of population health, measurement of health status, interventions to enhance health of populations and integration of theoretical, methodological and empirical approaches. Current Major Areas of Research : • Aboriginal and population health • Child and adolescent health • Epidemiology and public health aspects of cancer, addictions (smoking and alcohol),

infectious disease, chronic disease(eg. Arthritis, diabetes), accidents and injuries • Gerontology health and aging • Health professions and organizations • Health promotion and disease prevention • Methodological research in epidemiology, biostatistics and demography • Methodology: qualitative, quantitative, evaluation • Occupational and environmental health • Prevention of transmission of HIV/AIDS - Text last updated June 2006


44


DEPARTMENT: Radiation Oncology


Total Number of Awards: 73 Primary Appointments 113 On Campus 0 Off Campus 113 Cross Appointments 6 CIHR $519,999 Tenured 0 NSERC $32,534 Tenure-stream 0 NCIC $1,440,491 Career Awards 2 HLTH CAN $0 With Research Funds MOH $120,125 Primary Appointments 30 HSFO/C $0 Cross Appointments 3 SSHRC $0 Studentship Awards: Industry $1,295,176 Supervised by Primary Appt n/a Other Sources $3,889,000 Fellows: Post-Doc. and Clin. 21

Overall Research Objective : Excellence in clinical and translational, basic science, and physics and imaging research related to radiation medicine. Current Major Areas of Research : • Molecular radiation biology of tumour and normal tissues • Image guided radiation therapy • Clinical trials • Tumour microenvironment and treatment outcome • Health services research For more information about the Department of Radiation Oncology contact: Dr. Anthony Fyles 416-946-6522 [email protected] - Text last updated June 2006


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DEPARTMENT: Speech-Language Pathology


Total Number of Awards: 129 Primary Appointments 24 On Campus 11 Off Campus 13 Cross Appointments 10 CIHR $288,188 Tenured 10 NSERC $16,980 Tenure-stream 3 NCIC $0 Career Awards 1 HLTH CAN $0 With Research Funds MOH $243,652 Primary Appointments 10 HSFO/C $101,589 Cross Appointments 1 SSHRC $19,725 Studentship Awards: Industry $0 Supervised by Primary Appt 114 Other Sources $829,503 Fellows: Post-Doc. and Clin. 0

Overall Research Objective : To advance knowledge of the neurological, behavioural, and social aspects of communication and swallowing. There are two primary foci: normal and disordered speech and swallowing, and language development and disorders across the lifespan. Research linkages have been forged through collaborative projects with engineering, neurological imaging, dentistry, linguistics, psychiatry and gastroenterology among others. Another research objective is to develop improved models of clinical management of communication disorders. Clinical research is being undertaken in the areas of augmentative and alternative communication, speech fluency, developmental language disorders, hearing loss, acquired aphasia and apraxia of speech among others. Current Major Areas of Research : Members of the Graduate Department of Speech-Language Pathology pursue research in the following major areas, each represented by a contact person identified below. For more information about our three graduate programs and a detailed list of faculty and their research, please inquire at 500 University Avenue, 10th Floor. Motor speech disorders and swallowing C. Steele 978-8330 Developmental speech and language disorders L. Girolametto 978-3353 Acquired language disorders (aphasia and dementia) E. Rochon 978-8332 C. Leonard 978-8332 Voice and resonance disorders T. Bressmann 978-7088 Speech motor control and stuttering L. De Nil 978-1789 Augmentative and alternative communication B. O’Keefe 978-6890 Developmental speech and language disorders C. Johnson 978-8331 Speech physiology and speech motor control P. Van Lieshout 978-8334 Childhood hearing loss A. Eriks-Brophy 946-8633 Swallowing R. Matino 946-8644 Stuttering R. Kroll 978-1789 International Rehabilitation P. Parnes 946-8556 Aphasia Treatment Outcomes A. Kagan 978-2770 - Text last updated June 2006


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DEPARTMENT: Surgery


Total Number of Awards: 441 Primary Appointments 301 On Campus 7 Off Campus 294 Cross Appointments 58 CIHR $6,510,899 Tenured 3 NSERC $276,001 Tenure-stream 0 NCIC $999,212 Career Awards 15 HLTH CAN $0 With Research Funds MOH $120,125 Primary Appointments 124 HSFO/C $1,219,255 Cross Appointments n/a SSHRC $0 Studentship Awards: Industry $2,651,925 Supervised by Primary Appt 141 Other Sources $13,793,698 Fellows: Post-Doc. and Clin. 65

Overall Research Objective : Development of excellence in research programs including the training of Surgeon-Scientists. Current Major Areas of Research : • The pathophysiology of diseases of clinical interest of surgeons • The clinical epidemiology and result of treatment outcomes of disorders treated by surgeons • Development of experimental models of surgical diseases (e.g., genetically modified mice) • Analysis of new therapies • Research into cellular mechanisms in repair and regeneration • Engineering and computing technology in surgery • Improving knowledge transfer and quality of care in Canada and abroad (including Third

World countries) - Text last updated June 2006


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NOTES TO THE AFFILIATED TEACHING HOSPITALS Summary of Research Funding and Personnel

In this section of the Synopsis, research funding and demographic data is summarized by the research location of the principal investigator. Included are summaries for nine University of Toronto affiliated teaching hospitals and one other institutional affiliate. Total Research Funding includes grants, contracts and awards received by principal investigators, located at the affiliate, during the period April 1, 2004 to March 31, 2005. The total represents direct research grants and does not include funding awarded to implement or maintain research infrastructure. Total Number of Awards is the number of distinct research projects awarded to principal investigators only. This total does not include research grants awarded to non-Faculty of Medicine investigators who are located at the affiliates. The Number of Principal Investigators who were awarded research funding and/or a career award is shown. The number of Studentship Grant Awards, (graduate and undergraduate) supervised by a primary appointment located at the affiliate, is listed. The number of Post-Doctoral Research and Clinical Research Fellows, located at the affiliate who are research trainees reported by each center is shown. Overall Research Objective and Current Major Areas of Research describe the research focus of each hospital. This information is provided by each affiliate hospital and published here unedited except for formating changes as required by page size constraints.


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FACULTY OF MEDICINE – UNIVERSITY OF TORONTO AFFILIATED TEACHING HOSPITALS: 2004 - 2005

Total Research Funding: $383,655,2441

Total Number of Awards: 4333 Canadian Institutes of Health Research (CIHR) $90,602,129 Natural Sciences and Engineering Research Council (NSERC) $2,470,494 National Cancer Institute of Canada (NCIC) $24,468,397 Health Canada (HLTH CAN) $1,046,965 Ontario Ministry of Health (MOH) $11,804,749 Heart and Stroke Foundation of Ontario/Canada (HSFO/C) $9,558,965 Social Sciences & Humanities Research Council (SSHRC) $409,389 Industry Sources $34,238,892 Other Sources $209,055,262

Number of Principal Investigators with: Research Awards 1037 Career Awards 178 Studentship Awards: Supervised by Primary Appointment 1244 Fellows: Post-Doctoral and Clinical Research Fellows 715

Based on data from each Affiliated Hospital

1 Excludes CFI/OIT physical infrastructure grants in the amount of $37,327,772 as well as $12,946,032 from the Federal Indirect Costs program awarded to the affiliated hospitals. Excludes research funding awarded to non-Faculty of Medicine investigators located at the affiliated teaching hospitals.


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HOSPITAL: Baycrest Centre for Geriatric Care

Total Research Funding: $2,824,061 Number of Principal Investigators with:

Total Number of Awards: 31 Research Funds 13 Career Awards 3 CIHR $1,429,201 Studentship Grant Awards: NSERC $0 NCIC $0 Supervised by Investigator 8 HLTH CAN $0 MOH $0 Fellows: HSFO/C $367,166 SSHRC $194,246 Post-Doc. and Clin. 7 Industry $0 Other Sources $833,447

Overall Research Objective : To promote effective care and improved quality of life of individuals as they age, through research into, cognitive, mental health, psychosocial and medical factors. The two interdisciplinary research group at Baycrest Centre for Geriatric Care are complementary, integrating basic and applied research. Current Major Areas of Research : The Rotman Research Institute has a cognitive neuroscience focus on memory and frontal lobe functions of the brain in dementia, stroke, mood disorders, head injury and normal aging. The research in the Kunin-Lunenfeld Applied Research Unit is applied from a variety of perspectives, including therapeutic interventions, data base analyses, clinical trials, and models of interventions and rehabilitation. - Text last updated June 2006


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HOSPITAL: Bloorview Kid’s Rehab ( formerly Bloorview MacMillan Children’s Centre )

Total Research Funding: $656,017 Number of Principal Investigators with:

Total Number of Awards: 18 Research Funds 8 Career Awards 2 CIHR $84,449 Studentship Grant Awards: NSERC $60,415 NCIC $0 Supervised by Investigator 1 HLTH CAN $0 MOH $40,000 Fellows: HSFO/C $0 SSHRC $0 Post-Doc. and Clin. 0 Industry $0 Other Sources $471,153

Overall Research Objective : International leadership in paediatric rehabilation research. The mandate is to improve the quality of life and quality of care for children and youth with disability and special needs. Current Major Areas of Research : • Outocmes Measurement • Evidence-based care • Innovation & Development • Participation - Text last updated June 2006


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HOSPITAL: Centre for Addiction and Mental Health


Total Number of Awards: 239 Research Funds 82 Career Awards 14 CIHR $6,407,836 Studentship Grant Awards: NSERC $11,532 NCIC $80,967 Supervised by Investigator 46 HLTH CAN $601,416 MOH $3,743,145 Fellows: HSFO/C $62,430 SSHRC $67,298 Post-Doc. and Clin. 42 Industry $5,601,541 Other Sources $7,563,441

Overall Research Objective : Research excellence continues to be an integral part of the Centre for Addiction and Mental Health (CAMH).CAMH is committed to continuing its development of excellence in research and scholarship in the area of addictions, mental illness and mental health. Complementary to its role in delivering excellent health care, CAMH has a role in providing leadership through the development and dissemination of new knowledge.CAMH emphasizes research in basic and clinical sciences, health systems, community development and social evaluation. It respects the diversity of scientific and scholarly activity that will be valuable in improving understanding and care. Current Major Areas of Research : Neuroscience Research: Behavioural pharmacology, biopsychology, clinical neuroscience, human neurochemical pathology laboratory, laboratory of cellular and molecular pathophysiology, molecular neuroscience, molecular pharmacology, neurobiology of alcohol, neuroimaging, pharmacogenetics, psychiatric neurogenetics, smoking and nicotine dependence, Transgenic Facility and Positron Emission Tomography Centre. Clincial Research Department: Addictions; mood and anxiety; Schizophrenia; Child, Youth and Family; and Law and Mental Health Social, Prevention and Health Policy Research Department: Culture, Community and Health Studies, Health Systems Research and Consulting Unit, Ontario Tobacco Research Unit, Population and Life Course Studies, Public Health and Regulatory Policy s, Social Factors and Prevention Interventions, Women’s Mental Health research Positron Emission Tomography Centre: Research at the Vivian M. Rakoff Positron Emission Tomography (PET) Centre concentrates in the following areas: PET Me thodology (Radiochemistry and PET Instrumentation); Schizophrenia; Mood Neurochemistry; Basic Neurosciences and Addiction. In addition to our own research, we maintain active collaboration with other scientists within CAMH and with researchers at the University of Toronto and its affiliated teaching hospitals. - Text last updated June 2006


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HOSPITAL: The Hospital for Sick Children


Total Number of Awards: 896 Research Funds 207 Career Awards 52 CIHR $21,804,823 Studentship Grant Awards: NSERC $434,149 NCIC $2,595,455 Supervised by Investigator 265 HLTH CAN $9,990 MOH $216 Fellows: HSFO/C $2,115,355 SSHRC $71,260 Post-Doc. and Clin. 289 Industry $2,787,172 Other Sources $25,352,684

Overall Research Objective : To excel in basic and clinical research that leads to improved understanding, prevention, treatment and care of children's diseases. Current Major Areas of Research : • Brain and behaviour research • Cancer and blood research • Cardiovascular research • Cell biology • Computational biology • Developmental biology • Genetics and genomic biology • Infection, immunity, injury and repair research • Integrative biology • Lung biology research • Metabolism research • Population health sciences • Structural biology and biochemistry - Text last updated June 2006


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HOSPITAL: Mount Sinai Hospital


Total Number of Awards: 479 Research Funds 104 Career Awards 22 CIHR $17,274,330 Studentship Grant Awards: NSERC $674,258 NCIC $2,943,703 Supervised by Investigator 118 HLTH CAN $0 MOH $1,505,839 Fellows: HSFO/C $402,610 SSHRC $0 Post-Doc. and Clin. 70 Industry $5,185,060 Other Sources $34,298,410

Overall Research Objective : The Samuel Lunenfeld Research Institute of Mount Sinai Hospital is committed to excellence in biomedical research and in the training of young investigators. Its mission is to advance scientific knowledge, to ensure the application of such knowledge to the promotion of human health and to assist Mount Sinai Hospital in meeting its mission as a leading health care facility. Current Major Areas of Research : • Cancer genetics • Systems biology • Epidemiology of complex diseases • Genomic medicine • Mammalian genetics and integrative biology • Neurodevelopment and cognitive function • Stem cells and tissue engineering • Women’s and infants’ health - Text last updated June 2006


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HOSPITAL: St. Michael's Hospital


Total Number of Awards: 675 Research Funds 144 Career Awards 15 CIHR $4,922,712 Studentship Grant Awards: NSERC $106,000 NCIC $60,793 Supervised by Investigator 128 HLTH CAN $93,000 MOH $12,407 Fellows: HSFO/C $1,198,239 SSHRC $11,668 Post-Doc. and Clin. 40 Industry $7,815,531 Other Sources $20,158,402

Overall Research Objective: The St. Michael's Hospital Research Centre’s goal is to reflect the hospital’s longstanding mission of caring for the most critically ill and vulnerable populations. This mission is achieved through a translational research platform, which spans defined research foci in critical care, inner city health and global health. Current Major Areas of Research: Critical Care Research: The critical care research matrix is comprised of three cross-cutting themes in regenerative medicine, inflammation/injury and molecular and genetic determinants of disease. These themes cross clinical specializations in vascular biology, trauma/respiratory failure, diabetes/kidney and blood research, which together form a comprehensive program in basic and clinical research. Inner City Health Research: The Centre for Research on Inner City Health is the first research centre of its kind in Canada whose mission is to improve the health of urban populations through a program of policy relevant research. Particular emphasis is placed on the needs of socially disadvantaged and economically deprived groups, including the homeless and underhoused, those suffering from mental illness and patients diagnosed with diseases including HIV/AIDS and tuberculosis. Global Health Research: The program in global health includes the Centre for Global Health Research which is focused on large scale epidemiology with emphasis on conducting research in India. Global health researchers are also focused on broader issues including international bioethics, infectious diseases in immigrant populations, HIV/AIDS intervention and prevention in Africa and health systems reform in China. - Text last updated June 2006


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HOSPITAL: Sunnybrook & Women’s College Health Sciences Centre Orthopaedic and Arthritic Site

Total Research Funding: N/A Number of Principal Investigators with:

Total Number of Awards: N/A Research Funds N/A Career Awards N/A CIHR N/A Studentship Grant Awards: NSERC N/A NCIC N/A Supervised by Investigator N/A HLTH CAN N/A MOH N/A Fellows: HSFO/C N/A SSHRC N/A Post-Doc. and Clin. N/A Industry N/A Other Sources N/A

Overall Research Objective : To identify and create new understanding pertaining to patients with musculoskeletal disease or injury with the purpose of integrating this gained knowledge and advancement of diagnosic and treatment interventions toward the achievement of innovative approaches to care and optimal patient functional outcomes. Current Major Areas of Research : • Clinical and functional outcome measures • Orthopaedic reconstructive surgery • Physiotherapy and rehabilitation • Specialized consultation regarding shoulder and elbow problems - Text last updated Apr 2005


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HOSPITAL: Sunnybrook & Women’s College Health Sciences Centre Sunnnybrook Site


Total Number of Awards: 426 Research Funds 129 Career Awards 20 CIHR $10,390,310 Studentship Grant Awards: NSERC $266,091 NCIC $3,407,008 Supervised by Investigator 108 HLTH CAN $24,931 MOH $616,881 Fellows: HSFO/C $1,344,471 SSHRC $10,000 Post-Doc. and Clin. 46 Industry $3,511,728 Other Sources $45,254,106

Research Objectives: The main aims of Sunnybrook Research Institute (SRI) are to understand and prevent disease, and develop treatments that enhance and extend life. These aims derive from a core vision: to achieve discovery and its translation into the clinic to set best practices. Major Areas of Research: Research at SRI spans the spectrum of discovery from basic science to translational research to knowledge transfer and commercialization. There are five disciplines: molecular and cellular biology, clinical integrative biology, imaging, clinical epidemiology and the Centre for Health Services Sciences. Each scientist aligns with a discipline and one of seven strategic clinical programs: aging and population health, cancer, cardiac, musculoskeletal, perinatal and gynecology, neurosciences, and trauma and critical care. This synergistic alignment supports activity that traverses basic, translational and clinical foci. Sunnybrook Research Institute’s 180 scientists and clinician-scientists are working in the following three priority science areas toward achieving the core vision: • Genes, proteins and cells: Research in this area, which spans strategic program areas with a particular emphasis

on regenerative medicine, aims to discover and explain how molecules and cells work toward preventing disease and improving diagnosis, treatment and prognosis. Main areas of expertise in this area are inflammation, infection and immunity, stem cell biology, cell cycle control, signal transduction, vascular modelling, angiogenesis and antiangiogenesis.

• Imaging: Research in this area concentrates on the development and refinement of technologies to visualize cells, tissues and organs. Blending physics, mathematics and engineering, SRI expertise spans multiple imaging modalities: ultrasound, magnetic resonance imaging, digital mammography and tomosynthesis, X-ray, and positron emission tomography / computed tomography. These technologies are clinically relevant to the diagnosis of disease, and the guiding and monitoring of therapies, including minimally invasive surgical techniques, across strategic program areas.

• Clinical epidemiology: Research in this area explores the causes, consequences and treatment of disease to improve patient care and ensure limited health care resources are used wisely. SRI expertise is in the application of epidemiologic methods to issues in medicine across strategic program areas. This includes analyzing disease incidence, treatment efficacy and long-term outcomes, as well as health policies and the economic impact of diagnostic tools and therapies. Methods are wide-ranging: randomized controlled trials, meta-analyses, surveys and database studies. Sunnybrook researchers work in close partnership with faculty at the Institute for Clinical Evaluative Sciences and with policy makers to inform decisions relevant to health care.



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HOSPITAL: Sunnybrook & Women’s College Health Sciences Centre Women’s College Site


Total Number of Awards: 65 Research Funds 39 Career Awards 3 CIHR $3,608,939 Studentship Grant Awards: NSERC $0 NCIC $701,723 Supervised by Investigator 6 HLTH CAN $250,000 MOH $1,048,399 Fellows: HSFO/C $53,000 SSHRC $35,000 Post-Doc. and Clin. Industry $399,554 Other Sources $6,507,018

Overall Research Objective : The WCACC conducts and fosters innovative, multidisciplinary research in women’s health and models of ambulatory care that is relevant to women’s lives, and promotes its application in diverse communities. Current Major Areas of Research : • Women and Cancer • Women and Violence • Reproductive and Sexual Health • Activity and Independence • Ambulatory care models - Text last updated June 2006


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HOSPITAL: Toronto Rehabilitation Institute


Total Number of Awards: 35 Research Funds 14 Career Awards 1 CIHR $443,665 Studentship Grant Awards: NSERC $0 NCIC $0 Supervised by Investigator 10 HLTH CAN $0 MOH $3,000,000 Fellows: HSFO/C $0 SSHRC $0 Post-Doc. and Clin. 3 Industry $63,569 Other Sources $1,129,620

Overall Research Objective : At Toronto Rehab our vision for research is to develop a comprehensive rehabilitation research program in Ontario by building research capacity, investing in innovation, and enhancing linkages and collaborations. Working together we will develop new and improved rehabilitation interventions that will enhance quality of life. Strong emphasis is placed on knowledge and technology transfer so that our work has the greatest impact. Current Major Areas of Research : • Activity • Cognition • Communication • Mobility • Optimization of the Rehab system • Technology • Sleep and Cardio-pulmonary function - Text last updated June 2006


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HOSPITAL: University Health Network


Total Number of Awards: 1430 Research Funds 297 Career Awards 46 CIHR $23,585,442 Studentship Grant Awards: NSERC $918,049 NCIC $14,678,748 Supervised by Investigator 554 HLTH CAN $67,628 MOH $1,534,762 Fellows: HSFO/C $4,015,694 SSHRC $0 Post-Doc. and Clin. 218 Industry $8,823,437 Other Sources $66,851,624

Overall Research Objective: To become one of the top ten hospital-based research institutes in the world. UHN affirms its commitment to building a full-spectrum research enterprise, one that seeks to achieve new advances in: 1) basic understanding of health and disease, 2) preventing disease, 3) improving clinical care, and 4) developing innovative treatments and diagnostic tools that extend and improve life. Current Major Areas of Research : Clinical and research focus in the following 7 program groupings: - Advanced medicine and surgery including digestive, kidney, respiratory, endocrine and infectious diseases. - Community and population health including seniors’, women’s, children’s and mental health. - Heart and circulation including cardiology, cardiac diagnostics and cardiac/vascular surgery. - Musculoskeletal health and arthritis including arthritis, arthroplasty, sports medicine, orthopaedics, and hand and plastic surgery. - Oncology and blood disorders including medical, surgical, radiation and psychosocial oncology as well as blood disorders. - Neural and sensory sciences including epilepsy, neurodegenerative diseases, neuromuscular, neuro-oncology, neuro-ophthalmology, neuro-urology, neurovascular diseases, ophthalmology, spinal, pain, swallowing and balance. - Transplantation including heart, lung, heart and lung, kidney, pancreas, kidney and pancreas, liver, small bowel, microsurgery and tissue. In addition, research launched development of 4 cross-cutting priority platforms which will fuel discovery in all areas of focus: - Genes, proteins and people (applying advanced genomic and proteomic tools to disease prevention, diagnosis and treatment). - Health informatics (providing global impact on the health of individuals through the development and integration of health research and care delivery systems). - Medical technology innovation (innovation and translation of technologies for medical research and practice, including image and signal processing, molecular imaging and targeting, robotics, tools, engineering and nanotechnology). - Regenerative medicine (innovative strategies for the treatment of human disease through engineering,reprogramming and replacing cells, tissues and systems). - Text last updated June 2006


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NOTES TO SUMMARY OF UNIVERSITY INTRA/EXTRADEPARTMENTAL UNITS

Affiliated with the Faculty of Medicine The information contained in this section of the Synopsis describes the multidisciplinary research initiatives of University intra/extradepartmental units affiliated with the Faculty of Medicine. Research funding awarded to intra/extradepartmental unit academic staff members is administered through the Faculty of Medicine department to which they are appointed or through the Office of the Vice-Dean Research. Where applicable, the following information is provided: • number of academic staff participating in the unit, • number of non-academic associates, • number of Faculty of Medicine students and fellows affiliated with the unit, • Faculty of Medicine departments, University of Toronto faculties, other universities and

organizations participating in the unit • overall research objective and current major areas of research.


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CENTRE: Banting and Best Diabetes Centre U of T Academic Staff : 86 Number of Graduate Studentships Awarded in 2004-2005: 16 Number of Postdoctoral Fellowships Awarded in 2004-2005: 4 Participating Departments : • Anaesthesia • Anthropology • Banting and Best Dept. of Medical

Research • Biochemistry • Chemical Engineering • Family and Community Medicine • Institute of Biomaterials & Biomedical

Engineering • Institute of Medical Sciences • Immunology • Laboratory Medicine & Pathobiology • Medical Biophysics • Medical Genetics & Microbiology

• Medicine • Nutritional Sciences • Obstetrics and Gynaecology • Ophthalmology and Vision Sciences • Offic Paediatrics e of the Associate

Dean, Continuing Education • Pharmacology • Physical Education and Health • Physiology • Psychiatry • Psychology • Public Health Sciences • Surgery

Other Participants : • Canadian Diabetes Association • TriHospital Diabetes Education Centre • Samuel Lunenfeld Research Institute • Hospital for Sick Children Research Institute Overall Research Objective : To foster programs of research, education and patient care in diabetes at the University of Toronto and its affiliated hospitals. To develop an endowment to support the activities of the Centre and to establish new research programs in areas related to diabetes in a number of clinical and basic sciences departments of the Faculty. Current Major Areas of Research : • Atherosclerosis • Clinical trials • Complications of diabetes • Diabetic nephropathy • Genetics of diabetes • Glucagon related peptides • Gut hormones • Immunology of diabetes • Insulin secretion • Insulin signaling • Integrative biology • Lipoprotein kinetics • Membrane biology • Molecular biology • Molecular genetics and evolution - Text last updated June 2006


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CENTRE: Joint Centre for Bioethics The University of Toronto Joint Centre for Bioethics is a partnership among the University of Toronto, Baycrest Centre for Geriatric Care, Bloorview Kids Rehab, Centre for Addiction and Mental Health, Centre for Clinical Ethics of Providence Centre, St. Joseph’s Health Centre, St. Michael’s Hospital, The Hospital for Sick Children, Humber River Regional Hospital, Mount Sinai Hospital, North York General Hospital, Ontatrio Genomics Institute, Toronto Community Care Access Centre, Sunnybrook Health Sciences Centre, Toronto East General Hospital, Toronto Rehabilitation Institute, Trillium Health Centre and University Health Network. The mission of the Joint Centre is to provide leadership in bioethics research, education and clinical activities. Students, Research Assistants and Fellows : The Joint Centre for Bioethics has a formal doctoral-stream Collaborative Program in Bioethics through the School of Graduate Studies. The participating graduate units are: Department of Health Policy, Management and Evaluation, Institute of Medical Science, Faculty of Law, Faculty of Nursing, Department of Philosophy, Department of Public Health Sciences and Department for the Study of Religion. The Joint Centre for Bioethics also has a professional MHSc degree in Bioethics through the Institute of Medical Science. Participating Departments in the Faculty : Almost all the departments in the Faculty participate in the Joint Centre for Bioethics. There is a clinical ethics fellowship and research grants support fellows, graduate students and research associates and assistants in specific projects. Other Participating Faculties and Departments : Arts and Science, Law, Management, and Nursing Overall Research Objective : To foster interdisciplinary research and scholarship, link education to research, and disseminate research findings to improve policies and practices. Current Major Areas of Research : • Canadian Program on Genomics and Global Health • Canadian Priority Setting Research Network • Organizational Ethics Research Group • Project to Examine Effectiveness in Clinical Ethics • Public Health Ethics Interest Group • Rehab and Continuing Care Ethics Research Group - Text last updated June 2006


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CENTRE: Clinical Science Division Academic Staff : 33 Students & Fellows : Graduate Students 52 Post-doctoral & Clinical Research Fellows 21 Participating Departments in the Faculty : • Medicine • Surgery Overall Research Objective : To foster a strong intellectual environment for clinician-scientists and basic scientists to undertake research programs alone, or in collaboration with one of the major research groupings and to provide a superior milieu for the training of research fellows and graduate students. Current Major Areas of Research : • Molecular Medicine Program • Cardiovascular sciences • Group in Membrane Biology • Gastroenterology/Nutrition • Hematology/Oncology • Infectious diseases/HIV • Renal physiology/pathophysiology • Respiratory sciences - Text last updated June 2006


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CENTRE: The Wilson Centre for Research in Education The Wilson Centre for Research in Education is dedicated to advance healthcare education and practice through research. It is designed to bring together health professional educators, basic scientists, clinical and rehabilitation scientists and community health care professionals for the purpose of conducting research aimed at improving curriculum, teaching, learning and evaluation. The overarching mission of the Wilson Centre is to i) foster the discovery and application of new knowledge relevant to advancing healthcare education and practice ii) promote creative synergies between diverse theoretical perspectives and between theory and practice, and iii) to be a world leader in education. Core Academic Staff : 10 Administrative Staff : 4

Acad. Cross Appointments: 110 Research Assistants: 3 Research Fellows 17

Participating Departments in the Faculty : • Anaesthesia • Division of Anatomy • Family & Community Medicine • Health Policy, Management &

Evaluation • Institute of Medical Science • Laboratory Medicine & Pathobiology • Medicine • Obstetrics & Gynaecology • Occupational Therapy

• Otolaryngology • Paediatrics • Physical Therapy • Psychiatry • Public Health Sciences • Medical Imaging • Radiation Oncology • Speech-Language Pathology • Surgery

Other Participating Faculties & Departments : OISE/UT, Library and Information Science, Institute for Medical Science, Standardized Patient Program, Surgical Skills Centre at Mount Sinai Hospital, Centre for Faculty Development at St. Michael’s Hospital, Program in eHealth Innovation, Faculty of Medicine Acadamies; Faculty of Nursing, Faculty of Pharmacy, Departments of Kinesiology, Psychology, Sociology, English and Engineering, Michener Institute. Other Participants : Ontario Medical Education Network, (McMaster University, Queen’s University, University of Ottawa, University of Western Ontario and Northern Ontario Medical School). Addis Ababa University in Ethiopia, Technion Medical School, Haifa, Israel and Imperial College, London, England. Participating Hospitals : All teaching hospitals affiliated with the University of Toronto. Overall Research Objective : To advance healthcare education and practice through research. Current Major Areas of Research : Programs of research which are drawn from: learners and learning environments and their evaluation and improvement, teachers and teaching evaluation and improvement, informatics in health professional education, interprofessional skills including team work communications, factors affecting diagnostic decision making, the psychometrics of performance-based assessment and the sociology of health professional education research, professionalism and healthcare delivery, computer assisted instruction, clinical and technical skills simulation and assessment, communication skills simulation and assessment, curriculum development and evaluation, interdisciplinary projects in cognitive sciences regarding clinical problem solving, critical thinking and memory, patient safety and medical error, the development of and changes in sciences, Health Sciences Faculties collaborative projects related to educational and practice outcomes of health professional education and faculty development. - Text last updated June 2006


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CENTRE: Gage Occupational & Environmental Health Unit Academic Staff : 15 Graduate Students : 30 The Gage Occupational and Environmental Health Unit is a collaborative program of the Departments of Medicine, and Public Health Sciences in the Faculty of Medicine and the Department of Occupational and Environmental Health at St. Michael’s Hospital. The mission of the Unit is to be a leading academic unit in workplace and environmental health, engaged in innovative research and education programs and services, all aimed at fostering the creation of healthy workplaces and environments. The Unit participates in teaching programs, including the undergraduate medical curriculum, the graduate programs of the Department of Public Health Sciences and the Institute of Medical Sciences, the residency program in Occupational Medicine, and the Diploma in Industrial Health. Research activities on effects of occupational and environmental agents, including characterization of exposure and adverse health effects, span the spectrum from basic science through clinical investigation to population-based studies and health services research related to the delivery of occupational health services. Overall Research Objective : To conduct basic and applied research into the causes, diagnosis, treatment and prevention of occupational and environmental health problems. Current Major Areas of Research : • Causes of occupational disease, diagnostic methods, natural history and outcomes with

particular interest in asthma, contact dermatitis, hand/arm vibration syndrome, noise • Delivery of occupational health programs, barriers to program delivery • Development and evaluation of methods for exposure assessment and characterization • Development and evaluation of methods for creation of exposures for chamber studies • Evaluation of diagnostic methods and outcomes • Exposure characterization and exposure methodology • Exposure modelling • Identification of groups at increased risk • Identification of mechanisms of adverse health effects of environmental and occupational air

contaminants • Occupational causes of cancer • Role of air contaminants in lung injury and inflammation - Text last updated May 2005


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CENTRE: Centre for Health Promotion Academic Staff : 3 Non-Academic Associates :59

Academic Associates : 20 Students : 6

PostDoctoral Fellows: 1 Studentship Awards: N/A Participating Departments in the Faculty : • Public Health Sciences

Other Participants: • University Health Service, Health News

Other Participating Faculties & Departments: • Centre for Urban and Community

Studies • Dentistry • Department of Sociology • Division of the Environment/Innis

College,

• Environmental Studies Program • Facilities and Services • Nursing • OISE/UT • Pharmacy • Physical and Health Education • Social Work

Participating Organizations : • Centre for Addiction & Mental Health • Centre for Health Information &

Promotion, Hospital for Sick Children • Promotion & Programs Branch, Ontario

Regional Office, Health Canada • Ontario Healthy Communities Coalition • Ontario Prevention Clearinghouse • Ontario Public Health Association • Public Health Branch, Ontario Ministry

of Health • Toronto Public Health • Centre for Urban Health Initiatives • Wellness & Lifestyle Program,

Centennial College • Centre for International Health • Canadian Society for International

Health

Overall Research Objective : To develop a program of research in health promotion provincially, nationally and internationally. Current Major Areas of Research : • Best practices in health care • Community action • Evaluation and needs assessment • Healthy communities/healthy universities • Healthy schools • Knowledge development • Health Literacy • Mental health promotion • Workplace health promotion - Text last updated June 2006


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CENTRE: Centre for International Health The Centre for International Health is committed to improving the 10/90 Gap in global health research, in which 90% of the world’s health research resources are focused on 10% of the world’s health burden. The CIH works to correct this imbalance by developing, facilitating and supporting multidisciplinary global health research and education opportunities in collaboration with many departments in the Faculty of Medicine and other University of Toronto faculties, programs, institutes and centres. It supports faculty members and students. The CIH enables and encourages global health research, education and advocacy. Growing collaborationa have been established with the Centre for Global Health Research, CISEPO, Office of International Surgery, Sprinkles Global Health Initiative and the International Centre for Disability and Rehabilitation. CIH will work closely with Sickkids new Global Child Health Initiative and the Global Pediatric Research Program. The CIH has developed into a national and international preeminent centre for scholarship and teaching. It enables and facilitates ideas, research and education to advance the University’s research priority, with a special emphasis on internalization. It builds strategic partnerships with global health research organizations and universities from all continents. The CIH won a competitive bid for the evaluation study of the South African Trust (SAT), an organization that combats AIDS in five sub-Saharan countries by building community HIV competency. CIH Director, David Zakus led a 6 member team on this endeavour. SAT represents one of CIDA's largest investment in addressing HIV/AIDS having spent approximately $70 million over ten years. The CIH’s mid-term review of SAT for CIDA will be making recommendations for SAT's strategic direction and programming. Participating Departments and Units in the Faculty of Medicine (selected): • Familty & Community Medicine • Health Policy, Management & Evaluation • Immunology • Otolaryngology • Paediatrics • Psychiatry • Public Health Sciences • Rehabilitation Sciences • Surgery • Obstetrics and Gynaecology • Medicine including Infectious Disease & Emergency

• Microbiology • IMS • Continuing Education • Joint Centre for Bioethics • Centre for Health Promotion • Centre for Research in Women’s Health • Centre for Global Health Research, St. Michael’s

Hospital • Silverman Centre for International Health, Mt. Sinai

Hospital

Other Multidisciplinary Collaborations: (selected) : • OISE • Faculty of Physical

Education • Faculty of Nursing • Faculty of Dentistry • Faculty of Arts and Science • Department of Anthropolgy

• Department of Sociology, Scarborough

• Division of Social Sciences, Erindale

• Faculty of Music • Faculty of Architecture • New College

• University College • Faculty of Pharmacy • Faculty of Law • Faculty of Social Work • Faculty of Engineering

Overall Research Objective: Implementing, facilitating and supporting multidisciplinary research focused on issues of relating to health problems affecting the world’s poorest and most vulnerable. Current Major Areas of Research: • Primary Health Care Development – Cambodia • Rural Health System Reform – China • Urban Community Health Development – China

• HIV/AIDS –Zambia, Namibia,Tanzania and Kenya; South Africa, Ethiopia, Nigeria, Malawi

The Centre facilitates research and with funds from the Medical Alumni Association, sends more than 50 students and residents to various countries around the world to carry out research and elective projects. • Total Number of Studentship Awards = 27 • Total Number of Resident Awards = 23 • Post-doctoral or Clinical Fellows (involved in research) = 1 - Text last updated June 2006


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CENTRE: R.S. McLaughlin Centre for Molecular Medicine The R. Samuel Mclaugh lin Centre for Molecular Medicine (MCMM) was established with a vision of improving health through the application of molecular advances to clinical care. Founded with a 50 million dollar endowment matched by institutional partners, the Centre is a joint initiative of the University of Toronto and four affiliated hospital-based research institutions: the Hospital for Sick Children, Mount Sinai Hospital, University Health Network, and Sunnybrook and Women’s College Health Sciences Centre. The Centre seeks to become a global leader in translational research by attracting the best and brightest scientists who share in, and wish to realize, this vision. Under the direction of Dr. Keith Stewart research efforts at the MCMM have been organized into four distinct program groupings. These four programs are Molecular Therapeutics, Global Health, Computational Genomics and Regenerative Medicine. Academic Staff : 41 Participating Departments and Units : • Biochemistry • Biochemistry and Structural Biology • Chemical Engineering and Applied

Chemistry • Chemistry • Immunology • Institute of Biomaterials and Biomedical

Engineering

• Institute of Medical Science • Joint Centre for Bioethics • Laboratory Medicine and Pathobiology • Medical Biophysics • Medical Genetics and Microbiology • Medicine • Pharmacology

Other : • Centre for Addiction and Mental Health • Ontario Innovation Trust • Saint Michael’s Hospital

• Structural Genomics Consortium • Toronto Medical Laboratories

Overall Research Objective: To improve health care through advances in molecular discovery. Research will be patient and health care focused at all times. Current Major Areas of Research: • Computational Genomics : - Autism and epilepsy • Global Health : - Malaria and tuberculosis • Molecular Therapeutics : - Autoimmune inflammatory disease and cancer drug discovery • Regenerative Medicine : - Cardiac repair, spinal cord repair and stem cell biology - Text last updated June 2006


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CENTRE: Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research

The mission of the Heart & Stroke/Richard Lewar Centre of Excellence (HSRLCE) is to bring the best of cardiovascular sciences at the University of Toronto together, including basic sciences, clinical investigations, and community health. Research at the Centre is focused on the prevention and cure of atheroslerosis, hypertension, heart failure and congenital heart disease. From this research will evolve diagnostic, prognostic, and therapeutic innovations that can impact on the health of all Canadians. Since its inception in 1999, the Centre has attracted over 80 principal investigators across the University’s campus, including the disciplines of cardiology, cardiovascular surgery, genetics, immunology, health services research, laboratory medicine and pathobiology, phsiology, physical therapy, psychology and and biomedical engineering. Working groups within the Centre have leveraged several large group grants, including ones on transgenic physiology, vascular biology, heart failure, and health outcomes research. The Centre also supports research studentships and fellowships, and has received a national, large-scale strategic training program grant from the CIHR Institutes of Circulatory and Respiratory Health, Genetics and Health Services Policy Research and the Heart and Stroke Foundation. The Centre supplements this program with its own fellowship and graduate studentship funding program, and hosts a number of educational events to facilitate enhanced collaborative research across institutions and disciplines. Trainee support : Total number of Studentship Awards: 6 Total number of Post-doctoral for Clinical Fellows (involved in research): 22 Participating Departments: Anaesthesia, Chemical Engineering & Applied Chemistry, Banting & Best Department of Medical Research, Biochemistry, Institute of Biomaterials & Biomedical Engineering, Laboratory Medicine & Pathobiology, Mechanical & Industrial Engineering, Medical Biophysics, Medicine, Molecular and Medical Genetics, Obstetrics & Gynaecology, Pharmacology, Physical Therapy, Physiology, Psychology and Surgery Overall Research Objective : Recruitment of top level scientists within focused priority programs. Development of collaborative infrastructure to facilitate knowledge, technique sharing, and the specific goals of our research programs. Formation of distinct research platforms with identified leaders and infrastructure to develop programs to answer key questions. Training of the next generation of research leaders (facilitated by our Fellowship Program). Improved communication, collaboration and enhanced profile within the local cardiovascular community. Current Major Areas of Research : For the next five years, the Centre’s priority research programs are: • State-of-the-Art Transgenic Physiology Laboratory, located in the FitzGerald Building • Development of Innovative cardiovascular therapies, including Personalized Medicine

(involving translation of basic biomedical research into clinical applications) • Clinical genomics and proteomics • Vascular Biology • Regenerative Medicine, focusing on Stem Cells and Gene Therapy • Biomarkers of Heart Failure and other Cardiovascular Diseases • Cardiovascular Complications of Diabetes - Text last updated June 2006


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CENTRE: Centre for Research in Neurodegenerative Diseases Academic Staff : 10 Students & Fellows : Post-Doctoral Fellows 17 Ph.D. Students 7 Research Associates 3 Participating Departments in the Faculty: • Laboratory Medicine and Pathobiology • Medical Biophysics • Medicine Overall Research Objective : To identify the possible causes and treatments for Alzheimer's Disease, amyotrophic lateral sclerosis, Parkinson’s Disease and other human neurodegenerative diseases. Current Major Areas of Research : • Alpha-synuclein biochemistry • Amyloid neurotoxicity • Animal models of Alzheimer’s Disease, spinocerebellar ataxias, Parkinson’s Disease • Brain trophic factors and neuron rescue • Cytoskeletal proteins in health and neurodegenerative disease • Gene expression in Alzheimer's Disease • Genetic basis of familial neurodegenerative disease • Genetics of Amyotrophic Lateral Sclerosis (Lou Gehrig’s Disease) • Genetics of Parkinson’s Disease • Genetics of spinocerebellar ataxias • Pharmacokinetics of anti-dementia drugs • Protein structure, protein-protein interactions - Text last updated June 2006


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CENTRE: Positron Emission Tomography (PET) Centre The PET Centre located at the Centre for Addiction and Mental Health is dedicated to the application of Positron Emission Tomography (PET) in the field of brain research. The PET Centre fosters multidisciplinary PET research within the University of Toronto academic community. The PET Centre has an internal research program as well as collaborative research projects with investigators both within the Centre for Addiction and Mental Health and within the University of Toronto neuroscience community. The facility is equipped with a Scanditronix 17-MeV cyclotron and radiochemistry laboratories for the production of radiotracers labelled with carbon-11 and fluorine-18. The PET facility also houses research laboratories for the development of new PET radiotracers. PET scans are acquired with a high resolution, high sensitivity research tomograph, recently installed at the PET Centre. The PET Centre has acquiried a whole-body PET/CT scanner that will provide new opportunities for the University research community. Overall Research Objective : To understand the metabolic and neurochemical basis of mental health, addiction and neurological disorders. To study the mechanisms of action, in the living human brain, of drugs currently used to treat these disorders and participate in the development and optimization of new pharmacological therapies. To develop new PET radioligands, new animal models and new methodologies to study these disorders. Current Major Areas of Research : • Radiochemistry: The Centre has recently developed a new radioligand for the serotonin

transporter and is currently working on new tracers for the norepinephrine transporter and the amyloid plaques of Alzheimer’s Disease. New PET radioligands are under development. These will broaden the scope of research carried out at the PET Centre.

• Schizophrenia: Role of the dopamine system in Schizophrenia and the optimization of neuroleptic treatment.

• Mood: Neurochemical basis for mood disorders, particularly the serotonin and dopamine systems, and the neurochemical effects of antidepressant therapy.

• Neuroscience: Development of new animal models. Use of radiation probe system for pharmacological studies in rodents.

• Addictions: Assessing the effects of MDMA (ecstasy) on the human brain. • PET instrumentation: Development of new 3D reconstruction techniques and hardware for

our new scanner. - Text last updated May 2005


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CENTRE: Centre for Sleep Medicine & Circadian Biology Academic Staff: 29 Participating Departments in the Faculty : • Medicine • Surgery

• Paediatrics • Psychiatry

• Otolaryngology

Other Participating Faculties and Departments : • Faculty of Arts & Science • Dentistry • Psychology The Centre for Sleep Medicine and Chronobiology serves as the focus for fundamental and clinical research on biologic rhythms, sleep-wake physiology and their roles as determinants to health and disease. Undergraduate, graduate, professional, technical, industrial/government, public and continuing medical educational programmes are offered. Sleep disorders laboratories and clinics in six university affiliated hospitals provide diagnostic and treatment services for patients with various sleep-related medical disorders. These laboratories and clinics are located in The Hospital for Sick Children, Mount Sinai Hospital, St. Michael’s Hospital, The Toronto General Hospital, The Toronto Western Hospital, Toronto Rehabilitation Institute and West Park Hospital. Clinical chronopharmacology is being carried out at the Sunnybrook Site of SWCHSC. Fundamental research is being carried out in laboratories at the Medical Sciences Building, Departments of Zoology, Physiology and Psychology, Clarke Site of CAMH and at the Toronto Western Research Institute. The mission of the Centre is to understand the fundamental operations of the sleeping-waking brain and its influence on the neurological, respiratory and cardiovascular systems. The goals of the Centre are to understand how rhythmicity is produced and controlled in health and disease; to improve treatments for sleep-related medical and psychiatric disorders and to eliminate human performance inefficiencies resulting from shift work, time zone travel and abnormal sleep-wake activity. Overall Research Objective : To understand the molecular, neurobiological and biochemical mechanisms that produce biological rhythms and that affect rhythmic behaviours. To discover the roles of the neuroimmune and neuroendocrine systems of the sleeping-waking brain in health and disease. To determine the molecular and physiological mechanisms of common rhythmic and sleep-related medical and psychiatric disorders. To understand the mechanisms of the biological time-keeping systems that affect the occurrence and treatment of disease. To improve diagnostic services and develop more effective, safe and efficient therapeutic methods for sleep-related medical and psychiatric disorders. To advise on procedures that would facilitate optimal work performance and well-being of those engaged in night-time or shift work. Current Major Areas of Research: • Biologic rhythms • Neuroendocrine research • Behavioural immunology • Chronopharmacology • Comparative sleep-wake physiology • Sleep-wake disorders • Human performance and function • Respiratory physiology and sleep apnea • Sleep and cardiovascular disease - Text last updated May 2005


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CENTRE: Centre for The Study of Pain Participating Departments in the Faculty: • Anaesthesia • Biomedical Communications • Medicine • Occupational Therapy • Paediatrics • Pharmacology • Physical Therapy • Physiology • Surgery Other Participating Faculties & Departments: • Dentistry • Library & Information Science • Nursing • Pharmacy • Social Work Other Affiliates: Comprehensive Pain Program, Toronto Western Hospital, Wasser Pain Management Centre and Mount Sinai Hospital Overall Research Objective : The University of Toronto Centre for the Study of Pain is a partnership involving the Faculties of Dentistry, Medicine, Nursing and Pharmacy. The mission of the Centre is to lead, both nationally and internationally, in pain research, education, and clinical activities. The vision of the Centre is to be a model of interdisciplinary collaboration to create and disseminate knowledge about pain, and to promote excellence in scholarship. The main goals of the Centre are to foster research and scholarship leading to an understanding of the mechanisms of pain and its alleviation; link research and education in pain so as to effect the dissemination and application of new knowledge in pain; develop, implement and support coordinated educational programs in pain at undergraduate, graduate and post-graduate levels; foster a multi-disciplinary approach in clinical research activities in pain, including collaboration between basic and clinical science; develop and provide continuing education programs for health care providers aimed at the dissemination of information derived from research and clinical evidence. Current educational activities of the Centre include an intensive week-long multi-disciplinary course in pain focusing on pain assessment and management for undergraduate students within the various health sciences disciplines at the University of Toronto. In addition, the Centre holds regular bi-monthly educational seminars and guest lecturer series. Current Major Areas of Research : • Brain imaging & pain • Chronic pelvic region & genital pain • Genetics of pain • Health innovations in pain management • Human electrophysiological studies on pain • Orofacial pain syndromes • Neuropathic pain • Pediatric pain- • Synaptic physiology and plasticity in pain • - Text last updated May 2005


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CENTRE: Centre for Research In Women’s Health The Centre for Research in Women’s Health (CRWH) is a partnership between Sunnybrook & Women’s College Health Sciences Centre and the University of Torotnto. Founded in 1995, CRWH works to promote and foster women’s health research across the University of Toronto and its affiliated institutions. CRWH has identified three areas of strategic focus: • integrate research in women’s health from cell to society • foster the next generation of women’s health researchers • be the benchmark for integration of research and knowledge exchange in women’s health Core Faculty : 22 Members: 73 Graduate and Post-Doctoral Students supervised by Faculty and Members : 161 CRWH works with a broad range of partners – in clinical settings, academia and community agencies. CRWH builds partnerships with scholars and research groups across the University and has member researchers in a broad range of departments and faculties. Participating Departments and Units : • Anaesthesia • Centre for Addiction and Mental Health • Centre for International Health • Centre for Research in

Neurodegenerative Disease • Family and Community Medicine • Health Policy, Management &

Evaluation • Joint Centre for Bioethics • Mount Sinai Hospital

• Obstetrics & Gynaecology • Paediatrics • Physiology • Psychiatry • Public Health Sciences • Sunnybrook & Women’s Health

Sciences Centre • University Health Network

Other : • Dentistry • Law • Nursing

• OISE • Physical Education & Health • Women’s Studies

Overall Research Objective: The Centre for Research in Women’s Health integrates scientific and humanistic perspectives to conduct and foster research relevant to women’s lives and to promote its application in diverse communities Current Major Areas of Research: Cancers Common in Women – epidemiological study of the genetic mutations associated with breast and ovarian cancer, as well as prevention and treatment for high-risk women; participatory community-based research, particularly with women from marginalized communities, to understand women’s experiences with breast cancer and to improve care and support Disability and Chronic Conditions – osteoporosis prevention and treatment; care models for post-fracture care; gender disparities in arthritis treatment Gender and Women’s Lives – the impact of global economic change on women’s health; national survey exploring how women’s social roles influence their mental and physical health Reproductive Health – international randomized clinical trials of critical questions about care during pregnancy, labour and delivery; pharmacy provision of emergency contraception Violence and Health – medical/legal responses to sexual assault; anti-violence training for health care providers; intimate partner violence in specific ethnocultural communities Women’s mental Health – mood disorders and the associated biological and social factors; pregnancy and depression; the links between mental health and violence; mental health and chronic disease - Text last updated June 2006


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GROUP: Bone and Mineral Group Academic Staff : 54 Participating Departments in the Faculty: • Laboratory Medicine & Pathobiology • Medicine • Molecular and Medical Genetics • Obstetrics and Gynaecology • Orthopaedic Surgery • Public Health Sciences • Paediatrics Other Participants: • CIHR Group in Matrix Dynamics • Faculty of Dentistry, Oral Physiology • Peridontics • Institute of Biomaterials and Biomedical • Engineering • Women’s Health Program Overall Research Objective : To develop collaborative research on the basic biology of bone, osteoporosis, and other bone disorders using cellular and molecular biology as well as epidemiology and translational approaches. Current Major Areas of Research : • Animal models of bone diseases • Cellular and molecular biology of bone structure and function • Clinical trials related to treatment of osteoporosis and other bone diseases • Endocrine physiology of bone • Epidemiology of osteoporosis • Mechanical properties of bone • Molecular genetics of bone diseases • Paediatric bone disease • Fracture treatment and prevention • Determinants of bone fragility Activity : • Sponsor osteoporosis grand rounds in collaboration with UHN, MSH and St. Michael’s

Hospital • Organize research seminars • Organize annual Research Day – ‘Bone and Mineral Research’ • Sponsor an annual scholarship Awards - 1 studenship was awarded to Ms Sophia Chang (Biochemistry) working under the supervision of Dr. Bernhard Ganss in the CIHR group in Matrix Dynamic for the academic year 2005-2006. -There are many graduate students and post-doctoral as well as clinical fellows working with members of the Bone and Mineral Group but not sponsor by us. - Text last updated June 2006


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GROUP: Drug Safety Research Group Academic Staff : 25 Students & Fellows : Graduate Students: 84 Post-doctoral & Clinical Research Fellows: 18 Participating Departments/ Divisions in the Faculty : • Medicine • Oncology • Paediatrics • Pharmacology • Psychopharmacology Other Participating Faculties and Hospitals/Institutes : • Faculty of Pharmacy • The Hospital for Sick Children Research Inst. • Centre for Addiction & Mental Health (Addiction Research Foundation Site) • Ontario Cancer Institute • Sunnybrook & Women’s College Health Sciences Centre Overall Research Objective : The Group mission is to improve risk management of medications and chemicals through coordinated research activities in drug safety. The Group is committed to promote effective communication of scientific progress in drug safety research. We believe that joint efforts in drug safety research will help to optimize health care overall. The Group will provide a leadership role nationally and internationally in promoting rational and safe therapeutics. The Group interacts with organizations outside of academia, including regulatory agencies and the pharmaceutical industry. Current Major Areas of Research : • Drug safety in lactation • Drug safety in pregnancy • Drug safety in women • Early human pharmacology studies • Economics of drug reactions • Mechanisms of teratogenesis • Metabolic basis for drug reactions • Pharmacogenetics • Risk management of drug toxicity • Testing for drug safety • Toxicology in vitro • Xenobiotic metabolism - Text last updated May 2005


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INSTITUTE: Institute of Medical Science Academic Staff : 513 Participating Departments in the Faculty : The Institute of Medical Science is the graduate unit for all the clinical departments in the Faculty of Medicine (with the exception of Laboratory Medicine & Pathobiology). Its multidisciplinary faculty represents virtually every department in the Faculty of Medicine and includes members from other faculties across the U of T campus. The faculty and students are located on the University campus in the Medical Sciences Building, as well as in the various Hospital Research Institutes that form the University of Toronto Health Sciences Complex. Overall Research Objective : To provide structured education and training of individuals for research careers in traditional biomedical sciences (molecular/cellular and integrative biology) as well as in clinical investigation/health services research and bioethics. This is fulfilled by provision of programmes at the graduate level, and also includes participation in the MD/PhD programme. The emphasis is on the development of research skills backed by broad exposure to medical science and biology that will lead the student to independent scholarship and inquiry. The programmes are directed to both professional and non-professional students, although a special mission of the IMS is the training of clinician scientists. The IMS also participates in the Royal College of Physicians and Surgeons Clinician Investigator Program, and also houses the Masters of Science in Biomedical Communication, and the Masters of Health Science & Bioethics. - Text last updated June 2006


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INSTITUTE: Institute for Work & Health

Number of Principal Investigators with:

Research Funds 12 Career Awards 1 Studentship Grant Awards: Supervised by Investigator 8 Fellows: Post-Doc. and Clin. 2

Overall Research Objective : The mission of the Institute for Work & Health is to research and promote new ways to prevent workplace disability, improve treatment, optimal recovery and safe return to work. The Institute is dedicated to research and to the transfer of research results into practice by the healthcare providers, workplace parties and other policy makers. Through the Institute’s association with the University community, and the Institute’s access to workplaces and key sources of data, it has also become an important training ground for graduate students and young investigators. Current Major Areas of Research : • Behavioural consequences of insurance and regulation • Epidemiology of disability • Evidence-based practice • Labour market experiences and health • Measurement of health and function • Prevention of Disability • Statistical methods • Workplace interventions and evaluations - Text last updated June 2006


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PROGRAM: Cardiovascular Collaborative Program Academic Staff : 74 Graduate Students : 37 Participating Departments and Units : • Anesthesia • Exercise Science • Health Policy, Mgmt & Evaluation • Inst. of Biomaterials & Biomed Eng • Inst. of Medical Science • Laboratory Medicine & Pathobiology • Medical Biophysics • Medicine • Pharmacology • Physiology • Public Health Sciences • Rehabilitation Science • Surgery Overall Research Objective : To develop cooperative and joint graduate teaching and research across departmental boundaries within the Faculty of Medicine and with the Faculty of Physical Education & Health to enhance the visibility of cardiovascular studies and to facilitate interdisciplinary training and research. Current Major Areas of Research : • Biochemistry of membrane lipids • Cyanotic heart disease • Exercise science • Gender related to cardiovascular studies • Gene expression • Growth factors • Haematology • Heart/lung/kidney • Hypertension/atherosclerosis • Hypertrophy/cardiomyopathy • Infarction/heart failure • Molecular biology • Myocardial protection • Paediatric/fetal development • Retinal blood flow • Sympathetic nervous system • Transplantation • Vascular haemodynamics - Text last updated June 2006


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PROGRAM: Multi Organ Transplant Program Academic Staff : 38 Students & Fellows : Graduate Students 86 Post Doctoral & Clinical Research Fellows 42 Participating University Departments : • Biochemistry • Immunology • Medical Genetics & Microbiology • Medical Imaging • Medicine • Paediatrics

• Laboratory Medicine & Pathobiology • Pharmacology • Psychiatry • Sociology • Surgery

Sites : Mount Sinai Hospital, St. Michael’s Hospital, University Health Network and Medical Sciences Building, University of Toronto Overall Research Objective : To build a Centre of the highest clinical and academic quality for patient care, research and education in the field of immunology and transplantation. The program is founded on the belief that multidisciplinary collaboration and effective communication among team members will support continuous quality improvement. Current Major Areas of Research : Research constitutes a major thrust of the Multi Organ Transplant Program with activities in both basic science of immunology/transplantation as well as the clinical outcomes research. A thematic approach to research has now been adopted with basic science programs in the following areas: • Mechanisms of antigen recognition and rejection • Studies of organ preservation injury • Cellular and molecular mechanisms of organ injury • Identification and characterization of new immunosuppressive agents • Mechanism of tolerance induction • Xenotransplantation • Stem cell technology • In vitro organogenesis • Pathogenesis of infectious disease in the immunocompromised host • Gene therapy • Genomics/proteomics As part of the program we have a CIHR funded Training program in Regenerative Medicine www.regenmedcanada.com (course and funding for fellows and students). For applications e-mail: [email protected] - Text last updated June 2006


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PROGRAM: Program in Neuroscience The Collaborative Program in Neuroscience was formed in 1987 and currently includes 15 departments in 5 faculties. All major areas of current neuroscience research are well represented in the Program. The Program aims to enrich the training of graduate students in neuroscience and to identify their specialization in this area on the degree awarded. The Program also provides researchers and students with a comprehensive listing of all neuroscience seminars and symposia at the Univerrsity of Toronto, a centralized listing of neuroscience courses and neuroscientists, an annual series of Distinguished Lecturers and poster day and a monthly newsletter. Students and Faculty: 145 graduate students: (75 PhD, 70 MSc/MA) are enrolled. Academic Staff : 179 Participating Departments and Units in the Faculty : SGS affiliated: • Biochemistry • Pharmacology • Institute of Biomaterials & Biomedical Eng. • Physiology • Institute of Medical Science • Rehabilitation Sciences • Laboratory Medicine & Pathobiology • Speech-Language Pathology • Medical Biophysics • Molecular and Medical Genetics Other: UofT Centre for the Study of Pain, Centre for Research in Neurodegenerative Diseases, Neuroscience Network of the Department of Physiology, University of Toronto, Centre for Addiction and Mental Health, Samuel Lunenfeld Research Institute and Wasser Pain Clinic at Mount Sinai Hospital, Brain and Behaviour Program at the Hospital for Sick Children, Krembil Neuroscience Program at Toronto Western Hospital, Toronto Western Research Institute, Vision Science at TWRI, Rotman Research Institute. Other Participating Faculties and Departments : • Faculty of Arts & Science • Psychology • Human Development & Applied Psychology • Zoology • Faculty of Dentistry • Faculty of Pharmacy Overall Research Objective: To promote and enhance graduate studies in neuroscience. To promote excellence in neuroscience research by providing improved communication, organizing symposia, fostering collaborative projects and organizing visits by distinguished internationally renowned neuroscientists. Current Major Areas of Research: Research areas are very diverse and cover most aspects of current neuroscience research; in particular, systems and cellular neurophysiology, genetic and molecular neuroscience, developmental biology, neurodegenerative diseases, neural modelling, clinical neurophysiology, and physiological psychology. Current studies include: synaptic structure and function, plasticity and learning at the synaptic and systems (auditory, somatosensory) levels, neurogenesis, motor control and motor learning, pathophysiology of Alzheimer’s Disease and movement disorders including Parkinson’s Disease, central mechanisms subserving acute and chronic pain, signal transduction, sensorimotor processes underlying normal and disordered speech, and regulation of neuronal calcium and its involvement in cell death. - Text last updated June 2006


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CONSORTIUM: Structural Genomics Consortium Total Research Funding: $50,388,652 Number of Principal Investigators with • Research Funds: 2 • Career Awards: 2*

* Both investigators’ career awards are administered through BBDMR Studentship Grant Awards: N/A Post-Doc Fellows: 13 Overall Research Objective: The Structural Genomics Consortium (SGC) is a pre-competitive, not-for-profit, charitable organization that provides open access to research in structural genomics, structural chemistry and computational chemistry as it relates to the improvement of human health and early stage drug discovery. It exists to supply the pharmaceutical and scientific communities with the structures and chemical landscapes of proteins and protein families that are critical targets for therapeutic design. Current Major Areas of Research: • Structural Genomics: The SGC deposited its 200th structure into the Protein Data Bank in

March 2006 and is currently operating at a pace of 170 structures per year with a focus on proteins and protein families of therapeutic importance.

• Membrane proteins: The SGC in engaged in a pilot project in the structural genomics of integral membrane proteins. Initial efforts focused on bacterial ion channels and resulted in the structures of two new bacterial ion channels (PDB codes 2BBJ and 1XL4/1XL6). Ongoing pilot-scale efforts are devoted exclusively to membrane proteins from human.

• Structural Chemistry: The SGC routinely performs chemical screens on its target proteins in order to identify compounds that promote protein purification or crystallization. About 20% of the SGC protein structures were determined in the presence of a compound derived from the SGC screening initiatives with natural and synthetic ligands.



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INDUSTRIAL FUNDING SOURCES We would like to acknowledge the sponsorship of our industrial partners. Total grants received: Greater than $1,000,000 GlaxoSmithKline Inc. Novartis Pharmaceuticals Canada Inc.

Pfizer Canada Inc.

Between $500,000 and $999,999 AMGEN Inc. Apotex Inc. AstraZeneca Canada Inc. Aventis Pasteur Ltd. Bayer Inc. Biogen Idec, Inc. Boston Scientific Ltd. Eli Lilly Canada Inc. LymphoSign Inc. Merck & Co., Inc.

Merck Frosst Canada Ltd. Northern Therapeutics Inc. Ortho Biotech, a Div. of Jansenn-Ortho Inc. Pfizer Inc. Sanofi-Aventis Structural Genomics Consortium The Toronto Medical Laboratories

Partnership Trillium Therapeutics Inc.

Between $200,000 and $499,999 Abbott Laboratories Ltd. Aegera Therapeutics Inc Almond Board of California Astellas Pharma Canada, Inc. Bell Canada Boehringer Ingelheim (Canada) Ltd. Bristol-Myers Squibb Foundation Inc. Bristol-Myers Squibb Pharmaceutical Group Elekta Ltd. Ellipsis Biotherapeutics Corporation Genzyme Corporation GlaxoSmithKline (Canada) Hoffmann-La Roche Inc. (Canada) Hoffmann-La Roche Ltd. Loblaw Companies Ltd.

McNeil Consumer Helathcare Canada Novartis Institute for Biomedical Research OncoTherapeutics Inc. SAIC - Frederick, Inc. Sanofi-Synthelabo Inc. Schering Canada Inc. Senesco technologies, Inc. Serono Canada, Inc. Solae, LLC Unilever Research Vlaardingen Varian Medical Systems, Inc. Vasogen Inc. Wyeth-Ayerst Canada Inc. ZOLL Medical Corporation

Between $100,000 and $199,999 ATF Advances Technologies and Fuels

Canada Inc. Acorda Therapeutics Inc. Centocor, Inc. Charles River Laboratories International,

Inc. Daiichi Eisai Medical Research Inc. Ellipsis Neurotherapeutics Inc. Exact Sciences Corporation Hemosol Inc. Idenix Pharmaceuticals, Inc. Innodia Inc. Janssen-Ortho Inc. KNS Canada Inc. Lupus Clinical Trials Consortium, Inc.

Maquet - Dynamed Medtronic of Canada Ltd OrbusNeich Pharm-Olam International Predix Pharma Procter & Gamble Pharmaceuticals Canada,

Inc. Purdue Pharma L.P. Q-Med AB St. Jude Medical Canada, Inc. Steba Beheer NV Syn X Pharma Vicuron Pharmaceuticals Inc. Xillix Technologies Corp. Z-Tech (Canada) Inc.


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Less than $100,000 ALTANA Pharma Inc. AMGEN Canada Inc. Achillion Pharmaceuticals Inc. Actelion Pharmaceuticals Canada Inc. Actelion Pharmaceuticals Ltd Alcoholic Beverage Med. Res. Foundation Alcon Inc. Alcon Research Ltd Allergan Inc. Allos Therapeutics, Inc. Alza Corporation Arginox Pharmaceuticals Inc. ArthroLab Inc. AtheroGencis Inc. Bausch & Lomb Inc. Baxter Healthcare Corporation Berlex Canada Inc. BioCardia Inc BioMs Technology Corporation Biorthex Inc. Boehringer Ingelheim Pharmaceuticals Inc. C.E.C. Industrial Consultants Inc. CELLutions Biosystems Inc. CV Therapeutics Inc Cangene Corporation Cardinal Health Cardiome Pharma Group Cargill Ltd. Celgene Corporation Cell Therapeutics, Inc. Cevena Bioproducts Inc. Chiron Corporation Coley Pharmaceutical Group Corgentech Inc. Covalon Technologies Inc. Covance Inc. Cyberonics Inc. Cyvex Nutrition Inc. Delex Therapies Inc. Edwards Lifesciences EHN inc. Elan Corporation, plc Elastin Products Company, Inc. Eli Lilly and Company Estracure Inc Expression Diagnostics FeRx Inc. FoldRx Pharmaceuticals, Inc. Friends Research Institute Inc. Genentech Inc. (US) General Electric Medical Systems Genesis Bio-Pharmaceuticals Genta Inc. Gilead Sciences Given Imaging Ltd.

GlaxoSmithKline Inc. Glycaemic Index Testing Inc. Guidant Canada H.J. Heinz Company of Canada Ltd. Healthcare Technology Systems Human Matrix Sciences LLC I D Biomedical Corporation of Quebec IBEX Technologies Immunex Corporation Innovations Foundation InterMune, Inc. Interface Biologics Inc. James Ewing Foundation Johnson & Johnson Kinetic Concepts, Inc. Lyco Red Natural Products Industries Ltd. MIGENIX, Inc. Mandarin Restaurant Franchise Corporation Marconi Corporation plc. MedPharmGene Inc. Medicure, Inc. Medtronic of Canada Ltd. Merck Sharp and Dohme MetRegen Metabolic Pharmaceutical Ltd MetriGenix Corporation Miikana Therapeutics Millennium Pharmaceuticals, Inc. Molecular Templates Inc. Myogen, Inc. Myriad Genetics, Inc. NDO Surgical, Inc. NPS Allelix Corporation Novartis Pharmaceuticals Corporation Novo Nordisk A/S Organon Canada Ltd. Ortho-Clinical Diagnostics Otsuka America Pharmaceutical Inc. PPD Development, Inc. Pfizer Inc. Pharmacyclics Inc. Philips Electronics North America

Corporation Picker International Inc. Possis Medical, Inc. Procter & Gamble Pharma Canada, Inc. QLT Inc. Quintiles Canada, Inc. Respironics Inc Rimon Therapeutics Ltd. SangStat Medical Corp. Sankyo Pharma Sanofi Winthrop Inc. Scion Natural Science Association Servier Canada Inc.


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Less than $100,000 (continued) Shire BioChem Inc Solvay Pharma Inc. St. Jude Medical, Inc. Stryker Biotech SuperGen, Inc. Targeted Genetics Corporation Teva Neuroscience, Inc. The BioBalance Corporation The Freedom Forum The Multiple Myeloma Research Foundation Tiense Suikerraffinaderii Services N.V. Tillotts Pharma AG Toronto Centre for Antimicrobial Research &

Evaluation Transkaryotic Therapies, Inc. Tyco Healthcare Group LP Uromed Corporation Valeant Pharmaceuticals International Viventia Biotech Wilson Cook Medical Corp Wright Medical Tech. Canada Ltd. Wyeth Yves Veggie Cuisine Zaric, Inc. Zeneca Pharma Inc


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OTHER FUNDING SOURCES We would like to acknowledge the sponsorship of our charitable, institutional and government

partners. Total grants received: Greater than $1,000,000 Arthritis Society Canada Foundation for Innovation Canada Research Chairs Program Canadian Breast Cancer Foundation Canadian Cystic Fibrosis Foundation Canadian Diabetes Association Cancer Care Ontario Gov’t.: Canada Research Chairs Gov’t: National Institutes of Health (US) Hospital for Sick Children Foundation Leukemia & Lymphoma Society Mount Sinai Hospital Multiple Sclerosis Society of Canada NCE: Canadian Stroke Network (CSN) NCE: Protein Engineering Network (PENCE) NCE: Stem Cell Network (SCN) Ontario Consortium for Image-guided

Therapy and Surgery

Ontario Genomics Institute Ontario Hospital Association Ontario Innovation Trust Ontario Mental Health Foundation Ontario Research and Dev Challenge Fund Physicians' Services Inc. Foundation Private Individuals Southern Research Institute St Michael's Hospital St. Michael's Hospital Sunnybrook & Women's College Health

Sciences Centre The McLaughlin Foundation The Ontario Cancer Research Network The Ontario HIV Treatment Network The Princess Margaret Hospital Foundation University Health Network Workplace Safety and Insurance Board

Between $500,000 and $99,999 Alzheimer Society of Canada Argonne National Laboratory Canadian Health Services Research

Foundation Cancer Research Society Inc. Government of Ontario: Ministry of Energy Government of the United States: Office of

Army Research John P. Robarts Research Institute Juvenile Diabetes Research Foundation

International

Kidney Foundation of Canada NCE: Canadian Genetic Diseases Network

(CGDN) NeuroScience Canada Ontario Neurotrauma Foundation Premier's Research Excellence Award Rutgers - State University of New Jersey The Michael J. Fox Foundation for

Parkinson's Research University of Pittsburgh University of Western Ontario

Between $200,000 and $499,999 Alzheimer's Association B.r.a.i.n. Child Banting & Best Diabetes Centre Bill & Melinda Gates Foundation Bloorview Childrens Hospital Foundation Canadian Association of Gastroenterology Canadian Blood Services Canadian Breast Cancer Research Alliance Canadian Centre on Substance Abuse Canadian Cystic Fibrosis Foundation Canadian Foundation for AIDS Research

(CANFAR) Canadian Tobacco Control Research

Initiative Cancer Care Ontario Case Western Reserve University

Children's & Women's Health Centre of British Columbia

Children's Hospital of Denver Christopher Reeve Paralysis Foundation College of Family Physicians of Canada Connaught Fund Eye Institute of Canada George Washington University Hamilton Health Sciences Corporation HealthOne Alliance Hospital for Sick Children Howard Hughes Medical Institute Laurentian University Lawson Foundation March of Dimes Birth Defects Foundation

(U.S.)


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Between $200,000 and $499,999 (continued)

McGill University McLaughlin Centre for Molecular Medicine McMaster University Ministry of Research and Innnovation

(Ontario) Mount Sinai Hospital National Alliance for Research on

Schizophrenia and Depression National Opinion Research Centre National Sanitarium Association NCE: Advanced Foods and Materials

Network (AFMNet) NCE: Canadian Arthritis Network (CAN) NCE: Canadian Network for Vaccines and

Immunotherapeutics (CANVAC) NCE: Mathematics of Information

Technology & Complex Systems (MITACS)

Ontario Problem Gambling Research Centre Ontario Thoracic Society Parkinson Foundation of Canada The American Society of Clinical Oncology The Foundation Fighting Blindness -

Canada The James S. McDonnell Foundation The Ontario Council on Gradual Studies The Royal College of Physicians and

Surgeons of Canada The Stanley Medical Research Institute The Susan G. Komen Breast Cancer

Foundation The University of Texas Universite De Montreal University of British Columbia University of Michigan University of Pennsylvania York University

Between $100,000 and $199,999 American Foundation for Suicide Prevention Associated Medical Services, Inc. Bloorview MacMillan Children's Foundation Brigham & Women's Hospital Canadian HIV Trials Network Canadian Hemophilia Society Canadian Liver Foundation Canadian Psychiatric Research Foundation Cancer Research Institute (US) Centre for Addiction and Mental Health Columbia University New York Crohn's & Colitis Foundation of Canada CureSearch Children's Oncology Group Dairy Farmers of Canada Department of National Defence / Canadian

Forces Douglas Hospital Research Centre Elsa U Pardee Foundation Government of Canada: International

Development Research Centre Government of Canada: Public Works and

Government Services Canada Government of the United States: Centers

for Disease Control and Prevention Government of the United States: National

Institute on Alcohol Abuse and Alcoholism Juvenile Diabetes Research Foundation

Canada Massachusetts General Hospital Muscular Dystrophy Association (US)

NCE: Automobile of the 21st Century (AUTO 21)

NCE: Canadian Bacterial Diseases Network (CBDN)

NCE: Canadian Institute for Photonic Innovation (CIPI)

Ontario Innovation Trust Physical Medicine Research Foundation Queen's University Rensselaer Polytechnic Institute Retinoblastoma Solutions Rhode Island Hospital Savoy Foundation St. Jude Children's Research Hospital Stanley Foundation State University of New York The Anemia Institute for Research and

Education The Breast Cancer Research Foundation The Change Foundation The Hospital for Sick Children Psychiatry

Endowment Fund The Kym Sellers Foundation The University of Oklahoma Health The Wadsworth Foundation Toronto Rehabilitation Institute University of Guelph University of Texas at Dallas World Health Organization


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Less than $100,000 ALS Society of Canada Alcoholic Beverage Medical Research Amalgamated Transit Union MS American Society. for Gastrointestinal

Endoscopy American Association for Thoracic Surgery American Association for the American Association of Neurological

Surgeons American Cell Therapy Research

Foundation American College Radiology Imaging American Health Assistance Foundation American Heart Association Arbeitsgemeinschaft Fur

Osteosynthesefragen - Association for the Study of Internal Fixation

Association for Surgical Education Association of Hemophilia Clinic Directors of

Canada Banting Research Foundation Barbara Keenan Foundation Beatty Bennett Family Foundation Beverage INstitute for Health and Wellness Biotechnology and Biological Sciences

Research Institute Bloorview MacMillan Children's Ctr Borderline Personallity Disorder Research

Foundation Boston University Brain Tumor Fdn. of Canada C.R. Younger Foundation CIHR : Institute of Infection CIHR Interdisciplinary Health CanDRIVE Canadian Anaesthetists' Society Canadian Association of Radiation

Oncologists Canadian Coordinating Office for Health

Technology Assessment Canadian Dermatology Foundation Canadian Foundation for Dietetic Canadian Foundation for Women's Health Canadian Gene Cure Foundation Canadian Hypertension Society Canadian Institute of Ukrainian Studies Canadian Lung Association Canadian Paediatric Society Canadian Society for Clinical Pharmacology Canadian Urologic Oncology Group Cancer Research and Prevention

Foundation Center for Global Development

Child Neurology Foundation Children's Hosp of Pittsburgh Children's Hospital Boston Children's Hospital of Eastern Ontario Children's Hospital of The King's Daughters Cincinnati Children's Hospital Medical

Center City of Toronto City of Toronto Clifford Craid Medical Research Trust Collaborative Research Program:

Rehabilitation & Long-Term Care Crohn's & Colitis Foundation of America,

Inc. Cure Autism Now Foundation Cystic Fibrosis Foundation (US) Dalhousie University Dana-Farber Cancer Institute Dartmouth College Duke University Emory University Epilepsy Canada Estate of Betty Irene West Fanconi Anemia Research Fund, Inc. Fowler Kennedy Sport Medicine Clinic Fragile X Research Foundation of Canada Frontier Primary Health Care Gage Occupational & Environmental Genome Prairie Inc. Glaucoma Research Society Government of Canada: Canada Mortgage

and Housing Corporation Government of Canada: Canadian

International Development Agency Government of Canada: Industry Canada Government of Ontario: Ministry of

Agriculture and Rural Affairs Government of Ontario: Ministry of Finance Government of the United States:

Department of Agriculture Government of the United States:

Department of Energy Government of the United States:

Department of Veterans Affairs Grand River Hospital Harmonize for Speech Fund Health Innovation Human Frontier Science Program

Organization Huntington's Disease Society of America ICON Institute of Health Economics International Foundation for Music Research


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Less than $100,000 (continued) Internat. Institute for Research in Paraplegia International Union Against Cancer J.P. Bickell Foundation Kinnear Foundation Le Hopital Sainte-Justine Lesbian Health Fund Macula Vision Research Foundation Medical Council of Canada Medical University of Ohio Memorial University of Newfoundland Montreal Heart Institute Motor Neurone Disease Association Muscular Dystrophy Association of Canada National Alliance for Autism Research National Board of Medical Examiners National Childhood Cancer Foundation National Jewish Medical Research Center NCE: Canadian Language & Literacy

Research Network (CLLRNet) New York University North Kingston Needle Exchange Obsessive Compulsive Foundation Ontario Association of Medical Laboratories Ontario Cancer Institute Ontario Clinical Oncology Group Ontario I.O.O.F. Memorial Research

Committee Ontario Lupus Association Ontario Respiratory Care Society Ontario Tobacco Research Unit Oregon Health Sciences University Orthopaedic Research and Education

Foundation Otsuka Mayland Research Institute Ottawa Health Research Institute Paediatric Consultants Parkinson's Disease Foundation Pediatric Orthopaedic Society of Physiotherapy Foundation of Canada Prostate Cancer Research Foundation of

Canada Rett Syndrome Research Foundation Robert Wood Johnson Foundation Royal Society of Canada Ryerson Polytechnic Univ Shwachman-Diamond Syndrome Canada

International St Joseph Health Centre Stanford University The Alberta Emerald Foundation For

Environmental Excellence The American Society of Hematology The Assoc. for Internat. Cancer Research The Association of Professors of Obstetrics

& Gynaecology The Canadian Chiropractic Research

Foundation The Dr. Charles H. Best Foundation The EJLB Foundation The Gorbachev Foundation of North

America The Jarislowsky Foundation The Leukemia & Lymphoma Society of

Canada The Montreal General Hospital The National Surgical Adjuvant Breast and

Bowel Project (NSABP) The Ottawa Hospital The Rockefeller Foundation The Sanfilippo Children's Research

Foundation The Scottish Rite Charitable Foundation The Sir Jules Thorn Charitable Trust The Tema Conter Memorial Trust The Thoracic Surgery Foundation for

Research and Education The Workers' Compensation Board of BC Think First Foundation of Canada Thrombosis Interest Group of Canada Thyroid Foundation of Canada Toronto Transit Commission Trillium Foundation United Mitochondrial Disease Founda Universite de Shrebroke University Renal Research and Education

Association University of California - Irvine University of California, San Franc University of California-Davis University of Manitoba University of Maryland University of Massachusetts University of Minnesota University of Missouri University of North Carolina (CH) University of Ottawa University of P.E.I. University of Rochester University of Southern California University of Victoria University of Washington University of Waterloo Vanderbilt University Wake Forest University Washington University St Louis Wellcome Trust Wellesley Central Health Corporation Wellspring West Park Hospital Foundation


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Version 3: 13 August 2007

Based on RIS data snapshot: 4 June 2007, 1430hrs

TABLE OF CONTENTS Message from the Vice Dean, Research and International Relations ......................................IV Acknowledgements ........................................................................................................................XI Terms of Reference........................................................................................................................XII Tables and Figures Table 1: Summary of Department Research Funding vs Sponsor in THOUSANDS of Dollars....... 1 Table 2: 5-year Departmental Research Funding in THOUSANDS of Dollars By Campus vs

Affiliated Hospital Location..................................................................................................... 2 Table 3: Department Research Funding vs Location, All Sponsors for the year 2004/05 in

THOUSANDS of dollars......................................................................................................... 3 Table 4: Summary of Location Research vs Sponsor (Funding Source) in THOUSANDS of

Dollars .................................................................................................................................... 4 Table 2A: Research Funding 3-year Averages By Department for the periods: 2000-03, 2001-

04, 2002-05 ............................................................................................................................ 5 Table 2B: Research Funding 3-year Averages By Department in 2000 CONSTANT Dollars

for the periods: 2000-03, 2001-04, 2002-05.......................................................................... 6 Table 3A: Three-year AVERAGE of Department Research Funding vs Location, All Sponsors

for the years 2002/03, 2003/04 and 2004/05 in THOUSANDS of Dollars............................ 7 Table 3B: Three-year AVERAGE of Department Research Funding vs Location - Tri-Council

(CIHR / NSERC / SSHRC) only for the years 2002/03, 2003/04 and 2004/05 in THOUSANDS of Dollars ........................................................................................................ 8

Table 4A: Research Funding 3-year Averages By Location of Research for the periods: 2000-03, 2001-04, 2002-05............................................................................................................. 9

Table 4B: Research Funding 3-year Averages By Location of Research in 2000 CONSTANT Dollars for the periods: 2000-03, 2001-04, 2002-05 ........................................................... 10

Table 5: Research Funding By Source in THOUSANDS of Dollars, 8-year Distribution Profile .... 11 Figure 1: Comparison of Research Funding by Sponsor Source: 1987 to 2005............................ 12 Table 6: Research Funding By Type of Grant ................................................................................. 13 Table 7: Research Personnel by Department ................................................................................. 14 Table 8: Summary of Research Personnel Located at Affiliated Teaching Hospitals .................... 15 Table 9: Research Space at the University of Toronto Campus by Department............................ 16 Table 10: Graduate Student Funding (Awards and Stipends) by Income Source Type................ 17 Table 11: Graduate Student Funding (Awards and Stipends) by Graduate Unit........................... 18 Table 12: Graduate Student Funding (Awards and Stipends) by Administrative Location and

Source .................................................................................................................................. 19


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Departmental Synopses Notes to Faculty of Medicine Departments...................................................................................... 20 Summary of Department research funding and personnel ............................................................. 21 Anaesthesia...................................................................................................................................... 22 Banting and Best Department of Medical Research ....................................................................... 23 Biochemistry ..................................................................................................................................... 24 Family and Community Medicine..................................................................................................... 25 Health Policy, Management and Evaluation.................................................................................... 26 Immunology...................................................................................................................................... 27 Inst. of Biomaterials & Biomedical Engineering............................................................................... 28 Laboratory Medicine and Pathobiology ........................................................................................... 29 Medical Biophysics........................................................................................................................... 30 Medical Genetics & Microbiology..................................................................................................... 31 Medical Imaging ............................................................................................................................... 32 Medicine ........................................................................................................................................... 33 Nutritional Sciences.......................................................................................................................... 34 Obstetrics and Gynaecology............................................................................................................ 35 Occupational Therapy. ..................................................................................................................... 36 Ophthalmology and Vision Sciences ............................................................................................... 37 Otolaryngology ................................................................................................................................. 38 Paediatrics........................................................................................................................................ 39 Pharmacology................................................................................................................................... 40 Physical Therapy.............................................................................................................................. 41 Physiology ........................................................................................................................................ 42 Psychiatry ......................................................................................................................................... 43 Public Health Sciences..................................................................................................................... 44 Radiation Oncology.......................................................................................................................... 45 Speech-Language Pathology........................................................................................................... 46 Surgery ............................................................................................................................................. 47 Affiliated Teaching Hospital Synopses Notes to the Affiliated Teaching Hospitals ....................................................................................... 48 Summary of Hospital research funding and personnel ................................................................... 49 Baycrest Centre for Geriatric Care................................................................................................... 50 Bloorview Kid’s Rehab ( formerly The Bloorview MacMillan Children’s Centre) ............................ 51 Centre for Addiction and Mental Health........................................................................................... 52 The Hospital for Sick Children.......................................................................................................... 53


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Mount Sinai Hospital ........................................................................................................................ 54 St. Michael’s Hospital ....................................................................................................................... 55 Sunnybrook & Women’s College Health Sciences Centre, Orthopaedic & Arthritic Site ............... 56 Sunnybrook & Women’s College Health Sciences Centre, Sunnybrook Site................................. 57 Sunnybrook & Women’s College Health Sciences Centre, Women’s College Site ....................... 58 Toronto Rehabilitation Institute ........................................................................................................ 59 University Health Network................................................................................................................ 60 Intra/Extradepartmental Centre, Group, Institute, and Program Synopses Notes to Summary of Intra/Extradepartmental Units....................................................................... 61 Banting and Best Diabetes Centre................................................................................................... 62 Joint Centre for Bioethics ................................................................................................................. 63 Centre for Cellular & Biomolecular Research.................................................................................. 64 Clinical Science Division .................................................................................................................. 65 The Wilson Centre for Research in Education ................................................................................ 66 The Gage Occupational & Environmental Health Unit .................................................................... 67 Centre for Health Promotion ............................................................................................................ 68 Centre for International Health ........................................................................................................ 69 R.S. McLaughlin Centre for Molecular Medicine ............................................................................. 70 Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research ........................ 71 Centre for Research in Neurodegenerative Diseases..................................................................... 72 Positron Emission Tomography (PET) Centre ................................................................................ 73 Centre for Sleep Research............................................................................................................... 74 Centre for the Study of Pain............................................................................................................. 75 Centre for Research In Women’s Health ......................................................................................... 76 Bone and Mineral Group .................................................................................................................. 77 Drug Safety Research Group........................................................................................................... 78 Institute of Medical Science ............................................................................................................. 79 Institute for Work & Health ............................................................................................................... 80 Cardiovascular Sciences (Collaborative Program).......................................................................... 81 Multi Organ Transplant Program...................................................................................................... 82 Program in Neuroscience................................................................................................................. 83 Structural Genomics Consortium..................................................................................................... 84 Industrial Funding Sources .............................................................................................................. 85 Other Funding Sources .................................................................................................................... 88


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This synopsis highlights activities for the period 2005/06 by researchers situated on campus and at the research institutes of the following 10 fully affiliated hospitals: Baycrest Centre for Geriatric Care, Bloorview Kids Rehab, The Centre for Addiction and Mental Health, The Hospital for Sick Children, Mount Sinai Hospital, St. Michael's Hospital, Sunnybrook & Women’s, Toronto Rehab Institute and the University Health Network for the period 2005/06

Highlights of 2005-2006 • Change from 04/05 in CIHR and total research funding of 1% and -1%, respectively

• Canada Research Chairs (17 Chairs)

Tier 1 Gabrielle Boulianne Department of Medical Genetics and Microbiology Lynne Howell Department of Biochemistry Kullervo Hynenen Department of Medical Biophysics Conrad Liles Department of Medicine Michael Moran Banting and Best Department of Medical Research Norman Rosenblum Department of Paediatrics William Trimble Department of Biochemistry Shoshana Wodak Department of Biochemistry Jeff Wrana Department of Medical Genetics and Microbiology Tier 2 Michael Brudno Banting and Best Department of Medical Research John Cairney Department of Psychiatry Guri Giaever Faculty of Pharmacy Andrea Kassner Department of Medical Imaging Berge Minassian Department of Paediatrics Brian Raught Department of Medical Biophysics Janice Robertson Department of Laboratory Medicine and Pathobiology Ross Upshur Department of Family and Community Medicine

• Premier's Research Excellence Award (14 awards)

The Ontario government's PREA Program had two primary aims - 1) to improve Ontario's ability to attract and keep highly talented young researchers and graduate students, in order to conduct state-of-the-art research and 2) to enhance the development of promising researchers and students.


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In 2005, the following were recipients of this award: Nicola Jones Department of Paediatrics Sheena Josselyn Department of Physiology Alberto Martin Department Of Immunology Colin Mckerlie Department of Lab. Medicine and Pathobiology Janice Robertson Centre for Research in Neurodegenerative Diseases Lisa Robinson Department of Paediatrics Sean Rourke Department of Psychiatry Dean Rowe-Magnus Department of Laboratory Medicine & Pathobiology Chetankumar Tailor Department of Medical Genetics & Microbiology Anurag Tandon Centre for Research in Neurodegenerative Diseases Michael Tymianski Department of Surgery John Vincent Department of Psychiatry Minna Woo Department of Medicine Haibo Zhang Department of Anesthesia

Congratulations to all!

The publication of this the 20th edition of the Synopsis marks the end of my fifth year as Vice Dean, Research and International Relations. It’s been a pleasure to serve in this role and I look forward to beginning a second term to tackle the challenges I alluded to below. This year I am joined in this endeavor by colleagues Dr. George Fantus, our new Associate Dean, Research and Dr. Mingyao Liu, Director of International Research Relations. The creation of the CIHR, as well as the establishment of federal funding programs including the Canadian Foundation for Innovation, the Canada Research Chairs, and Genome Canada; and at the provincial level, the establishment of the Ontario Research Fund, and the Early Researcher Awards have dramatically improved the research climate in Canada and Ontario. The health research community in Toronto has benefited tremendously from the infrastructure and salary award funding. The recent “flat lining” of CIHR operating budget is a very worrisome development (last year we experienced only a 1% increase in CIHR, half the increase in the CPI). Our research engine is starving for fuel. What we need is balanced and stable funding commitments (operating, infrastructure and career awards) at both provincial and federal levels. We will advocate for this over the coming year.

Peter N. Lewis, Ph.D. Vice Dean, Research and International Relations July 3, 2007


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SYNOPSIS OF RESEARCH ACTIVITIES 2005 - 2006 The Synopsis of Research Activities in the Faculty of Medicine is published annually by the Faculty Research Office. This is the 20th edition, which covers the period from April 1, 2005 to March 31, 2006. It presents data and analysis of direct research funding and awards received by faculty members in the Faculty of Medicine for this period. These include operating grants, equipment and maintenance grants, and personnel awards to principal investigators, and trainees (graduate students, postdoctoral and clinical fellows) and other research related special grants. Data for the previous four years are presented for comparison. In addition, funding received (as opposed to the total project award) during this period from the Canadian Foundation for Innovation (CFI) and from the Ontario Innovation Trust (OIT) or ORF are reported in a separate category. Overhead received and indirect costs such as building maintenance, library and computing services, administrative services, faculty salaries and basic equipment cost and maintenance are not included. Funding received is segregated by departments and by geographic locations: on campus or in the affiliated hospitals. Guidelines defining research funding and its assignment are described in the Terms of Reference on page XII. The Faculty Research Office works closely with all Faculty departments, the affiliated hospitals and hospital research institutes to ensure that the data reported are as complete and accurate as possible.

INTRODUCTION The Faculty of Medicine at the University of Toronto is the largest medical faculty in Canada and ranks at the top in North America. Currently it admits 200 students to its first year of a 4-year undergraduate medical program. At the post-graduate level, it offers 65 specialty training programs leading to certification by the Royal College of Physicians and Surgeons of Canada, or by the College of Family Physicians of Canada. In addition to its primary responsibility in medical education, the Faculty participates heavily in the education of undergraduates in the Faculty of Arts and Science and in other health science faculties. To complete its educational role, members of the Faculty actively supervise a large number of graduate students enrolled in M.Sc. and Ph.D. programs, and organize and teach graduate courses. There are 26 departments in the Faculty including 9 departments in basic science (including the Institute of Biomaterials and Biomedical Engineering), 15 in clinical science (including the departments of Physical Therapy, Occupational Therapy and Speech-Language Pathology) and two in community health. In addition, there are 17 extra-departmental units (EDUs) organized as Centre, Division, Institute, Group, Unit, or Program. These units are inter-departmental in their structure and they engage in multidisciplinary research and education. The Faculty has almost 5,000 faculty members holding a range of academic positions that are fully or partly salaried on university budget, or non-salaried. The scope of research activity in the Faculty of Medicine is very broad, ranging from basic science, clinical investigation to community health and the rehabilitation sciences. There is a research continuum from the curiosity-driven to the applied. At one end are studies at the molecular and gene level to create fundamental knowledge crucial to our understanding of the normal and the disease biological process, leading to advancements in diagnosis, more


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effective prevention and treatment of disease. At the other end are research activities on the promotion of health and wellness, the improvement of rehabilitation, the prevention of disability and the development of policy on health and health administration. The Synopsis measures this large research enterprise in terms of its annual research revenues.

RESEARCH FUNDING: 2005 – 2006 Researchers in the Faculty of Medicine receive research funding from national, provincial and foreign funding agencies. These include the Canadian Institutes for Health Research (CIHR), Natural Sciences and Engineering Research Council (NSERC), Social Sciences and Humanities Research Council (SSHRC), Health Canada (HLTH CAN), and the Ontario Ministry of Health (MOH), and disease-oriented agencies such as the National Cancer Institute of Canada (NCIC), the Heart and Stroke Foundation of Ontario/Canada (HSFO/C), the National Institutes of Health, the Howard Hughes Medical Institute of the United States, and the US Department of Defense (Cancer Programs). In 2005/2006, the Faculty received a total of $510 million in research funds from all sources (Table 1), an increase of < 1% from the previous year of $508 million. This represents a rolling average growth of about 6% annually (Table 2B). Research grants accounted for about $451 million of this total, personnel awards accounting for the remaining $60 million (Table 6). All three sectors (the basic science, the community health, and the clinical (including rehab) sector) have continued to show a gain from the previous years (Table 2B). CIHR continued to be the single major source of funding accounting for about $124 million of the total, an increase of 1% from $122 million in the previous year. Other major single sources of funding were NCIC ($24 million) and the Ontario Ministry of Health ($18 million), with no change from the previous year. Funding from Health Canada doubled to $3.8 million. Funding from other sources including disease-oriented agencies and specific institutional awards remained constant at $282 million. Funding from industry remained the same at $38 million. Tables 2 and 3 show the "on campus" and "affiliated teaching hospital" geographical assignment of total research revenue. Assignment to hospital sites was about $407 million, accounting for 80 % of the total. Table 4 presents an analysis of the geographical distribution of grants and awards from the various funding agencies. During this period, investigators located in the affiliated teaching hospitals and on campus received $91 million and $32 million respectively from CIHR. Thus as a group, researchers located on campus maintained their share of about 25% of the total CIHR funding. Funding from sources identified as "Other" to campus-based investigators increased by $23 million to about $51 million whereas there was an increase of about $22 million to hospital-based researchers to $231 million.


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GOVERNMENT RESEARCH INFRASTRUCTURE PROGRAMS

Canadian Foundation for Innovation (CFI) began its infrastructure funding programs during 1999. At time of writing, CFI has awarded a total of 57 institutional projects from the Faculty and its affiliated hospitals. These projects were based on the following five research platforms identified by the Faculty in consultation with the departments and hospital research institutes:


About $23 million has been received from CFI and OIT, and from Genome Canada for 2005- 2006 down $14 million from the previous year. This does not include CFI New Opportunities awards which are included in the total research funding.

COMPARISON TO PREVIOUS YEARS Table 2A shows the annual research funding in current dollars by department from 2001 to 2006. The annual changes are analyzed as an average over a 3-year period. Table 2B shows the same data in 2001 constant dollars. All sectors have continued to grow. Overall, total research funding in current dollars over the 5-year period increased by $196 M, or $150 M in constant dollars since 2001. The research enterprise of the Faculty and its affiliated hospitals has stopped growing (Table 4A). Figure 1 shows that in the 16-year period beginning 1987, research revenue of the Faculty initially followed a linear rate of growth in spite of a slight hiatus from 1993 to 1995, a period of federal budget constraint on research. Recently the growth of research funding has hit a plateau. Table 5 presents the research funding by source in this and the previous seven years. Funding from Canadian federal sources showed an increase from $61 M in 1997/98 to nearly $210 M in 2005/06, for 38% of the Faculty total research revenue. Research revenue from provincial sources remained at about 15% of the total about the same as in 1997/98 (14%). Funding from not-for-profit organizations accounts for about 20% of the total, a net increase of $50 M from seven years ago. Industrial funding is the same as last year in its share of about 8% of the total research revenue (Figure 1).


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RESEARCH AWARDS The total number of research grants in 2005-2006 was 3,786, up 8% from the previous year of 3,503 (Table 6). The number of research personnel awards to principal investigators has increased by 5% from 169 to 176. 17 Canada Research Chairs were awarded in 2005/06.

FACULTY RESOURCES Academic Staff The academic staff in the Faculty of Medicine is a heterogeneous group in terms of their source of salary and the kind of academic appointment they hold. For the purpose of this report, there were 4,745 faculty members holding primary academic appointments in the Faculty (Table 7). These primary appointments range from being fully salaried to Status-Only (e.g. those employed and salaried by hospital research institutes). The profile of these faculty members is as follows, with the 2004-2005 figures in parenthesis: • 4,745 (4,944) hold primary appointments; of these 4,420 (4,521) are in affiliated hospitals • 327 (326) are located on campus; of these 164 (167) are tenured and 47 (38) are tenure-

stream • 1,268 (1,248) faculty members held research grants and 253 (241) received career awards The distribution of faculty members by sector, department, and geographical location is summarized and presented in Tables 7 and 8.

Research Fellows Postdoctoral fellows and clinical research fellows are major contributors to the research enterprise of the Faculty. Tables 7 and 8 summarize the distribution of postdoctoral fellows and clinical research fellows in the Faculty.

Graduate Student Funding – data for 2005/06 In 2005/2006 the total graduate student funding (awards and stipends) was $35.7M (36.6 M), of this $20.9M (19.7 M) were awards while $14.8M (17 M) were stipends as shown in Table 10. The award and stipend distribution by the Graduate unit is given in Table 11. The breakdown by administrative site is given in Table 12. The total funding supports about 2000 graduate students. Numbers in parentheses are 03/04


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Research Space On-campus research and research-support space in the Faculty has changed dramatically over the past few years. The Banting Institute, the Best Institute, the FitzGerald Building, the Medical Sciences Building, the McMurrich Building, the Tanz Neuroscience Building, the Gage Research Institute and the buildings at 1 Spadina, 256 McCaul Street, 82 and 88 College Street housed the Faculty for more than thirty five years. Five years ago a 10-storey building (6,700 nasm) at 500 University Avenue was purchased and now houses the Departments of Physical Therapy, Occupational Therapy, Speech- Language Pathology, and the Office of the Associate Dean, Continuing Education. Construction of the $96M Donnelly Centre for Cellular and Biomolecular Research (CCBR) was completed in 2005. The CCBR (10,000 nasm) has 25 faculty and will ultimately house 40 principal investigators and more than 500 research staff. Extensive renovations were made in 04/05 to the Banting Institute to house the Structural Genomics Consortium a $60M joint project with the UK. Three years ago the University purchased the former Board of Education building (155 College Street) which since has been extensively renovated and now houses 3 Faculty Departments – Public Health Sciences, Health Policy, Management and Evaluation, and Family and Community Medicine. The McMurrich Building, previously home to PHS and HPME, has been returned to the University for other purposes. The total campus research space of the Faculty of Medicine is 28,939 sq m (Table 9).


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ACKNOWLEGEMENTS We would like to acknowledge the support of Departmental Chairs, Research Directors and UofT/Hospital Research Administrators for providing information on research activities. We would like to thank collectively the numerous individuals who have contributed in one way or another to the tedious task of producing this report. We look forward to your continued support for next year’s report.


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appointment.

• These data are assigned to a principal investigator as identified by the grant application or through consultation with the departmental Chair.






to implement or maintain research infrastructure, e.g. CFI awards.



an RIS ‘by-Location’ Report download (data snapshot) initiated at 1430 hrs of June 4, 2007.




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AwardsBASICBBDMR 22,684 7,185 208 1,006 0 0 135 0 9 14,140 124Biochemistry 14,224 5,339 618 1,155 0 0 364 12 385 6,351 226Biomat & Biomed Eng 2,578 1,004 92 0 0 398 0 0 340 743 34Immunology 13,357 3,741 145 540 0 0 181 0 245 8,505 147Medical Biophysics 65,203 7,544 658 8,709 0 0 571 0 1,770 45,952 539Medical Genetics & Microbiology 57,933 14,290 768 4,120 0 0 189 0 1,159 37,407 504Nutritional Sciences 4,819 1,457 755 213 0 0 18 35 878 1,462 122Pharmacology 6,003 1,598 161 264 0 0 69 0 200 3,711 98Physiology 12,982 5,487 493 0 0 0 1,136 0 32 5,834 273

SUB-TOTAL 199,783 47,645 3,898 16,007 0 398 2,663 47 5,018 124,105 2,067COMMUNITY HEALTHHealth Policy, Mgmt & Eval 7,738 2,506 0 0 131 1,774 0 67 2 3,258 133Public Health Sciences 25,018 7,420 296 524 268 6,883 206 241 445 8,734 367

SUB-TOTAL 32,756 9,926 296 524 399 8,657 206 308 447 11,992 500CLINICALAnesthesia 3,814 1,355 12 0 0 0 34 0 494 1,920 95Family & Community Medicine 5,232 692 0 0 2,306 1,055 68 6 37 1,067 106Lab. Medicine & Pathobiology 24,198 7,336 1,038 1,404 0 0 1,894 0 3,699 8,826 402Medical Imaging 9,694 383 25 0 0 579 0 12 527 8,168 38Medicine 103,601 24,115 271 2,557 551 1,150 5,310 220 16,444 52,985 1,409Obstetrics & Gynaecology 8,083 5,776 73 0 0 0 65 0 229 1,940 84Occupational Therapy 1,665 243 14 0 0 0 0 123 57 1,228 196Ophthalmology And Vision Sci 4,917 859 26 148 0 1,067 21 0 562 2,233 86Otolaryngology 459 190 21 0 0 0 0 0 0 248 11Paediatrics 27,855 7,396 47 561 445 61 889 0 2,967 15,488 482Physical Therapy 2,527 432 56 0 0 414 117 6 0 1,502 249Psychiatry 22,685 7,224 58 183 35 875 300 301 2,377 11,331 353Radiation Oncology 8,229 863 64 1,177 0 120 0 0 1,109 4,896 79Speech-Language Pathology 1,650 354 23 0 19 0 111 87 12 1,043 149Surgery 38,942 7,407 226 1,154 0 820 1,569 0 4,079 23,689 500

SUB-TOTAL 263,551 64,625 1,954 7,184 3,356 6,141 10,378 755 32,593 136,564 4,239Other 1 14,394 1,453 0 0 0 3,000 45 25 416 9,456 45

TOTAL 510,484 123,649 6,148 23,715 3,755 18,196 13,292 1,135 38,474 282,117 6,851CFI/OIT 2 23,361 17Indirect Costs 3 7,837 10

GRAND TOTAL 4 541,682 (x $1000) 6,878

1 Includes global research budget of the Institute for Clinical Evaluative Sciences, Structural Genomics Consortium, SARS Laboratory, UofT Equipment maintenance grants, clinical trial grants at the Sunnybrook Hospital/University of Toronto Clinic, ORDCF grants, Ontario Genomics Institute grants, undergraduate summer studentship awards, graduate studentship awards for independent study and Health Communication Research Laboratory in the Faculty of Medicine and Federal Indirect Cost Programme.2 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Site of SWCHSC, University of Toronto and the University Health Network.





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DEPARTMENT Hospital Campus Hospital Campus Hospital Campus Hospital Campus Hospital CampusBASICBBDMR 858 7,591 1,626 9,591 3,142 8,539 2,482 44,760 1,561 21,123Biochemistry 6,430 2,875 5,835 4,493 6,035 3,551 16,274 4,479 9,321 4,904Biomat & Biomed Eng 1,364 594 1,337 464 1,664 452 987 1,170 1,663 914Immunology 4,679 908 5,363 1,013 5,870 1,141 9,154 1,591 9,929 3,429Medical Biophysics 29,201 552 37,811 500 46,157 682 72,793 1,629 64,082 1,121Medical Genetics & Microbiology 24,304 8,710 26,430 8,621 30,314 9,729 37,154 8,555 49,934 7,999Nutritional Sciences 946 2,775 961 2,608 2,034 2,520 1,607 3,410 1,634 3,184Pharmacology 1,290 2,039 1,097 2,565 1,268 2,657 1,339 2,717 1,079 4,923Physiology 3,887 6,436 4,275 6,757 4,763 6,452 4,714 6,561 5,567 7,415

SUB-TOTAL 72,959 32,480 84,735 36,612 101,247 35,723 146,504 74,872 144,770 55,012COMMUNITY HEALTHHealth Policy, Mgmt & Eval 683 2,724 1,135 6,824 1,368 5,476 1,819 6,660 1,327 6,411Public Health Sciences 10,206 7,540 10,410 7,789 11,265 7,563 13,916 10,098 17,653 7,365

SUB-TOTAL 10,889 10,264 11,545 14,613 12,633 13,039 15,735 16,758 18,980 13,776CLINICALAnesthesia 2,592 494 2,834 338 3,481 393 3,561 700 3,343 472Family & Community Medicine 1,096 0 1,463 108 1,781 204 4,010 785 4,722 510Lab. Medicine & Pathobiology 15,408 3,722 18,246 4,852 20,404 6,675 17,707 7,691 17,483 6,715Medical Imaging 3,904 0 3,400 4 3,174 5 7,325 15 9,514 179Medicine 52,401 8,839 64,308 10,081 71,622 10,798 88,744 16,133 88,088 15,514Obstetrics & Gynaecology 3,835 0 5,543 0 5,820 0 7,123 1 8,056 26Occupational Therapy 470 470 602 764 432 891 604 813 689 976Ophthalmology And Vision Sci 1,612 1,067 1,964 1,072 3,087 1,106 3,448 1,090 3,593 1,324Otolaryngology 476 0 471 0 487 0 426 21 445 14Paediatrics 19,677 4 21,417 14 20,531 33 20,562 201 27,665 190Physical Therapy 1,484 235 982 573 991 618 1,321 767 1,042 1,484Psychiatry 19,724 1,180 16,199 554 20,394 486 23,722 1,437 21,666 1,019Radiation Oncology 3,143 685 3,438 5 7,607 5 7,269 28 8,154 75Speech-Language Pathology 151 431 60 518 46 706 433 1,066 299 1,351Surgery 18,821 840 15,277 660 23,932 807 24,686 885 37,382 1,560

SUB-TOTAL 144,794 17,967 156,204 19,543 183,789 22,727 210,941 31,633 232,141 31,409Other 1 15,324 1,531 26,139 1,512 21,932 12,556 9,868 1,786 12,063 2,331

TOTAL 243,966 62,242 278,623 72,280 319,601 84,045 383,048 125,049 407,954 102,528CFI/OIT 2 37,174 2,665 27,286 7,900 41,551 18,913 19,187 18,141 18,462 4,900Indirect Costs 3 11,805 776 12,946 1,160 6,559 1,278


4 Grand Total and Fiscal Year Total for FYs 2003-2004, 2004-2005, 2005-2006 INCLUDE Indirect Costs awarded to the faculty of Medicine.




FY 2001-02 FY 2002-03 FY 2003-04 FY 2004-05 FY 2005-06

464,107386,091346,0471 Includes global research budget of the Institute for Clinical Evaluative Sciences, Structural Genomics Consortium, SARS Laboratory, UofT Equipment maintenance grants, clinical trial grants at the Sunnybrook Hospital/University of Toronto ClinicORDCF grants, Ontario Genomics Institute grants, undergraduate summer studentship awards, graduate studentship awards for independent study and Health Communication Research Laboratory in the Faculty of Medicine.2 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Site of SWCHSC, University of Toronto and the University Health Network

541,682559,532

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Department All Locations Campus Baycrest Bloorview CAMH HSC MSH SMH SWCHSC TRI UHN OtherBASICBBDMR 22,684 21,123 0 0 0 1,096 0 0 0 0 465 0Biochemistry 14,224 4,904 0 0 0 6,775 2,134 0 0 0 411 0Biomat & Biomed Eng 2,578 914 0 658 0 0 0 0 0 152 853 0Immunology 13,357 3,429 0 0 0 4,494 607 0 2,469 0 2,359 0Medical Biophysics 65,203 1,121 118 0 0 1,715 0 0 25,243 0 37,006 0Medical Genetics & Microbiology 57,933 7,999 0 0 9 25,319 22,662 0 0 0 1,944 0Nutritional Sciences 4,819 3,184 137 0 0 40 315 1,143 0 0 0 0Pharmacology 6,003 4,923 0 0 469 275 0 328 7 0 0 0Physiology 12,982 7,415 0 0 0 2,720 24 244 0 0 2,549 30

SUB-TOTAL 199,783 55,012 255 658 478 42,435 25,742 1,714 27,719 152 45,588 30COMMUNITY HEALTHHealth Policy, Mgmt & Eval 7,738 6,411 16 0 250 198 0 56 388 105 314 0Public Health Sciences 25,018 7,365 0 15 5,455 2,024 2,729 2,476 1,904 31 2,084 934

SUB-TOTAL 32,756 13,776 16 15 5,705 2,222 2,729 2,532 2,292 136 2,398 934CLINICALAnesthesia 3,814 472 0 0 0 668 131 1,177 275 0 1,091 0Family & Community Medicine 5,232 510 0 0 2,331 0 933 714 228 0 434 81Lab. Medicine & Pathobiology 24,198 6,715 0 0 0 3,443 5,653 692 1,834 0 5,861 0Medical Imaging 9,694 179 0 0 0 291 238 0 8,809 0 177 0Medicine 103,601 15,514 1,755 0 48 190 9,913 21,866 14,958 632 38,596 130Obstetrics & Gynaecology 8,083 26 0 0 0 0 4,933 227 2,793 0 104 0Occupational Therapy 1,665 976 0 116 0 0 0 231 0 217 0 125Ophthalmology And Vision Sci 4,917 1,324 0 0 0 948 0 607 0 0 2,038 0Otolaryngology 459 14 0 0 0 283 0 92 71 0 0 0Paediatrics 27,855 190 0 170 0 26,353 92 23 891 103 0 32Physical Therapy 2,527 1,484 99 20 0 0 0 6 519 215 164 20Psychiatry 22,685 1,019 1,052 0 13,638 1,093 99 925 829 146 3,830 53Radiation Oncology 8,229 75 0 0 0 0 0 0 1,621 0 6,533 0Speech-Language Pathology 1,650 1,351 0 65 0 0 0 0 111 119 3 0Surgery 38,942 1,560 0 0 55 6,527 3,571 3,013 3,343 9,596 11,277 0

SUB-TOTAL 263,550 31,409 2,906 371 16,072 39,796 25,563 29,572 36,282 11,028 70,109 441Other 14,394 2,331 0 0 0 1,506 2,996 95 4,276 3,000 191 0CFI/OIT 23,361 4,900 0 0 0 1,185 10,135 0 3,129 0 4,013 0Indirect Costs 1 7,837 1,278 0 0 985 299 145 31 859 1,246 2,995 0

GRAND TOTAL 541,682 108,705 3,177 1,044 22,255 87,143 67,166 33,914 73,698 14,316 122,299 1,4051 Excludes a total of $15,081,736 from the Federal Indirect Costs Program awarded to affiliate hospitals.

for the period: April 2005 to March 2006 in THOUSANDS of dollars.



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# of Awards

Baycrest Centre for Geriatric Care 3,177 1,656 54 0 0 74 451 199 0 744 31Bloowview MacMillab Children's Centre 1,044 103 60 0 0 0 0 0 547 333 23Centre for Addiction and Mental Health 22,255 4,961 5 18 2,009 4,127 52 250 1,604 9,229 238Hospital for Sick Children 85,958 21,680 525 2,832 445 533 2,364 65 4,433 53,082 1,079Mount Sinai Hospital 56,945 17,168 870 3,311 0 844 685 0 5,852 28,217 517St. Michael's Hospital 35,077 6,370 359 27 443 202 837 21 8,282 18,535 709SWCHSC

Sunnybrook site 63,356 9,095 204 2,563 0 999 1,939 0 2,838 45,718 320 Orthopaeic & Arthritic site 78 0 0 0 0 0 0 0 0 78 1 Women's College site 7,090 3,877 0 328 0 354 54 35 0 2,442 35Toronto Rehabilitation Institute 14,316 645 37 0 0 3,000 26 0 164 10,444 60University Health Network 118,179 25,138 763 10,961 523 2,544 4,483 20 11,923 61,824 1,357Other Hospitals 1 1,242 380 0 0 39 50 0 0 0 772 33



GRAND TOTAL 541,681 (x $1000) 6,878

1 Research at non-affilitaed hospitals.2 Research at other locations other than UofT Campus and other hospitals.3 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Site of SWCHSC, University of Toronto and the University Health Network.4 Federal Indirect Costs Program awarded to Faculty of Medicine


Summary of Location Research vs Sponsor (Funding Source) in THOUSANDS of DollarsApril2005 - March 2006

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4

DEPARTMENT FY 2001-02 FY 2002-03 FY 2003-04 FY 2004-05 FY 2005-06 2001-2004 2002-2005 2003-2006BASICAnatomy and Cell Biology 1 N/A N/A N/A N/A N/A N/A N/A N/ABBDMR 8,450 11,217 11,681 47,242 22,684 18.4 154.3 126.2Biochemistry 9,306 10,328 9,585 20,754 14,224 1.9 54.7 42.5Biomat & Biomed Eng 1,958 1,801 2,116 2,157 2,578 4.7 9.7 10.7Immunology 5,586 6,376 7,011 10,745 13,357 12.0 31.6 38.8Medical Biophysics 29,752 38,310 46,839 74,422 65,203 25.5 40.6 23.3Medical Genetics & Microbiology 33,014 35,051 40,043 45,709 57,933 10.2 14.2 20.4Nutritional Sciences 3,721 3,569 4,554 5,016 4,819 11.8 18.9 3.1Pharmacology 3,329 3,662 3,925 4,056 6,003 8.6 5.3 25.7Physiology 10,323 11,032 11,215 11,275 12,982 4.3 1.1 7.8


SUB-TOTAL 21,152 26,159 25,671 32,493 32,756 10.9 20.4 23.5CLINICALAnesthesia 3,086 3,172 3,874 4,262 3,814 12.5 16.1 -0.2Family & Community Medicine 1,096 1,571 1,985 4,796 5,232 34.8 84.0 75.3Lab. Medicine & Pathobiology 19,130 23,098 27,078 25,398 24,198 19.0 5.5 -5.5Medical Imaging 3,904 3,403 3,179 7,340 9,694 -9.7 62.2 81.5Medicine 61,239 74,389 82,421 104,876 103,601 16.1 19.0 13.0Obstetrics & Gynaecology 3,835 5,543 5,820 7,125 8,083 24.8 13.7 17.9Occupational Therapy 940 1,366 1,323 1,418 1,665 21.1 2.0 12.3Ophthalmology And Vision Sci 2,680 3,036 4,193 4,537 4,917 25.7 23.2 8.3Otolaryngology 476 471 487 447 459 1.1 -2.3 -2.7Paediatrics 19,682 21,431 20,563 20,763 27,855 2.4 -1.5 17.6Physical Therapy 1,719 1,555 1,609 2,089 2,527 -3.0 16.6 25.4Psychiatry 20,904 16,753 20,880 25,159 22,685 2.4 22.6 5.3Radiation Oncology 3,828 3,443 7,612 7,297 8,229 55.5 58.5 4.3Speech-Language Pathology 582 578 752 1,500 1,650 14.8 64.8 54.7Surgery 19,661 15,938 24,738 25,571 38,942 18.1 29.3 27.8

SUB-TOTAL 162,762 175,747 206,515 242,577 263,550 12.7 17.5 13.1Other 2 16,856 27,652 34,489 11,654 14,394 44.4 -20.7 -21.3

TOTAL 306,208 350,905 403,644 508,098 510,483 14.8 20.5 13.2CFI/OIT 3 39,839 35,186 60,464 37,328 23,361 30.1 16.8 -37.8Indirect Costs 4 1,160 7,837

GRAND TOTAL 346,047 386,091 464,107 545,426 541,682 15.9 18.9 8.4

1 Defunct Depertment of Anatomy and Cell Biology in 2001/022 Includes global research budget of the Institute for Clinical Evaluative Sciences, Structural Genomics Consortium, SARS Laboratory, UofT Equipment maintenance grants, clinical trial grants at the Sunnybrook Hospital/University of Toronto Clinic, ORDCF grants, Ontario Genomics Institute grants, undergraduate summer studentship awards, graduate studentship awards for independent study and Health Communication Research Laboratory in the Faculty of Medicine.3 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Site of SWCHSC, University of Toronto and the University Health Network.4 Federal Indirect Costs Program awarded to Faculty of Medicine



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5


DEPARTMENTBASICAnatomy and Cell Biology 1 N/A N/A N/A N/A N/A N/A N/A N/ABBDMR 8,450 10,997 11,125 44,151 20,811 15.7 149.0 122.0Biochemistry 9,306 10,125 9,129 19,396 13,050 -0.5 51.3 39.9Biomat & Biomed Eng 1,958 1,766 2,015 2,016 2,365 2.2 7.1 8.7Immunology 5,586 6,251 6,677 10,042 12,254 9.4 28.6 36.2Medical Biophysics 29,752 37,559 44,609 69,553 59,819 22.5 37.3 21.0Medical Genetics & Microbiology 33,014 34,364 38,136 42,718 53,150 7.5 11.5 18.2Nutritional Sciences 3,721 3,499 4,337 4,688 4,421 9.0 16.0 1.2Pharmacology 3,329 3,590 3,738 3,791 5,507 6.0 2.8 23.3Physiology 10,323 10,816 10,681 10,537 11,910 1.8 -1.3 5.8


SUB-TOTAL 21,152 25,646 24,449 30,367 30,051 8.3 15.3 19.3CLINICALAnesthesia 3,086 3,110 3,689 3,983 3,499 9.7 13.3 -2.1Family & Community Medicine 1,096 1,540 1,891 4,482 4,800 31.6 79.9 72.1Lab. Medicine & Pathobiology 19,130 22,645 25,789 23,736 22,200 16.1 3.0 -7.2Medical Imaging 3,904 3,337 3,027 6,860 8,893 -11.9 58.7 78.1Medicine 61,239 72,931 78,496 98,015 95,047 13.4 16.2 10.9Obstetrics & Gynaecology 3,835 5,434 5,543 6,659 7,416 21.9 11.1 15.7Occupational Therapy 940 1,339 1,260 1,325 1,527 18.3 -0.4 10.2Ophthalmology And Vision Sci 2,680 2,977 3,993 4,241 4,511 22.6 20.2 6.3Otolaryngology 476 461 464 418 421 -1.4 -4.7 -4.5Paediatrics 19,682 21,011 19,584 19,405 25,555 0.0 -3.9 15.4Physical Therapy 1,719 1,525 1,532 1,952 2,318 -5.4 13.9 23.1Psychiatry 20,904 16,425 19,886 23,513 20,812 -0.2 19.7 3.4Radiation Oncology 3,828 3,375 7,250 6,820 7,549 51.5 54.4 2.4Speech-Language Pathology 582 567 716 1,402 1,513 11.9 61.0 51.8Surgery 19,661 15,625 23,560 23,898 35,727 15.1 26.1 25.5

SUB-TOTAL 162,762 172,302 196,680 226,709 241,788 10.0 14.7 11.0Other 2 16,856 27,110 32,846 10,892 13,205 41.0 -22.8 -22.8


GRAND TOTAL 346,048 378,521 442,006 509,746 496,953 13.1 16.0 6.41 Defunct Depertment of Anatomy and Cell Biology in 2001/022 Includes global research budget of the Institute for Clinical Evaluative Sciences, Structural Genomics Consortium, SARS Laboratory, UofT Equipment maintenance grants, clinical trial grants at the Sunnybrook Hospital/University of Toronto Clinic, ORDCF grants, Ontario Genomics Institute grants, undergraduate summer studentship awards, graduate studentship awards for independent study and Health Communication Research Laboratory in the Faculty of Medicine.3 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Site of SWCHSC, University of Toronto and the University Health Network.4 Federal Indirect Costs Program awarded to Faculty of Medicine





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6

Department All Locations Campus Baycrest Bloorview CAMH HSC MSH SMH SWCHSC TRI UHN OtherBASICBBDMR 27,202 24,807 0 0 2 365 0 0 0 0 2,027 0Biochemistry 14,854 4,311 0 0 0 6,019 2,954 0 0 0 1,571 0Biomat & Biomed Eng 2,283 845 0 655 0 0 246 0 0 129 408 0Immunology 10,371 2,053 0 0 0 2,628 829 0 2,149 0 2,711 0Medical Biophysics 62,155 1,144 53 0 1 1,369 0 0 25,594 0 33,994 0Medical Genetics & Microbiology 47,895 8,761 0 0 3 14,781 22,888 0 14 0 1,448 0Nutritional Sciences 4,796 3,038 112 0 0 90 105 1,412 39 0 0 0Pharmacology 4,661 3,433 0 0 550 266 0 109 290 0 14 0Physiology 11,839 6,810 0 0 0 2,316 27 272 0 0 2,379 35SUB-TOTAL 186,056 55,202 165 655 556 27,834 27,049 1,793 28,086 129 44,552 35COMMUNITY HEALTHHealth Policy, Mgmt & Eval 7,687 6,182 20 0 151 157 25 19 409 121 552 52Public Health Sciences 23,271 8,342 7 5 5,158 1,699 2,326 1,230 1,917 25 1,213 1,348SUB-TOTAL 30,958 14,524 27 5 5,309 1,856 2,351 1,249 2,326 146 1,765 1,400CLINICALAnesthesia 3,983 522 0 3 0 558 100 970 284 0 1,546 0Family & Community Medicine 4,070 500 0 0 1,288 0 829 528 374 0 369 182Lab. Medicine & Pathobiology 25,558 7,027 0 0 0 3,350 6,141 928 2,108 0 5,971 34Medical Imaging 6,738 66 0 0 0 176 190 0 5,302 0 1,003 0Medicine 97,070 14,148 2,020 5 221 218 8,650 20,982 13,120 490 37,064 151Obstetrics & Gynaecology 7,009 9 0 0 0 0 3,967 221 2,716 0 95 0Occupational Therapy 1,482 893 26 128 0 4 0 196 0 179 0 55Ophthalmology And Vision Sci 4,549 1,173 0 0 0 819 0 521 5 0 2,031 0Otolaryngology 464 12 0 0 0 267 0 59 127 0 0 0Paediatrics 23,061 141 0 103 0 22,206 53 15 497 34 0 11Physical Therapy 2,249 956 33 61 0 1 61 13 515 327 97 187Psychiatry 23,012 981 747 0 14,637 1,265 237 760 813 96 3,329 147Radiation Oncology 7,713 36 0 0 0 0 0 0 1,922 0 5,755 0Speech-Language Pathology 1,300 1,041 0 30 0 7 0 0 152 63 8 0Surgery 29,750 1,084 0 16 33 5,512 3,211 2,298 3,770 3,199 10,627 0SUB-TOTAL 238,008 28,589 2,826 346 16,179 34,383 23,439 27,491 31,705 4,388 67,895 767Other hospitals 20,179 5,558 0 39 75 2,785 4,411 132 4,421 2,006 753 0GRAND TOTAL 475,201 103,873 3,018 1,045 22,119 66,858 57,250 30,665 66,538 6,669 114,965 2,202

for the periods: 2001-2004, 2002-2005 and 2003-2006 in THOUSANDS of Dollars



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7

Department All Locations Campus Baycrest Bloorview CAMH HSC MSH SMH SWCHSC TRI UHN OtherBASICBBDMR 5,498 5,455 0 0 0 13 0 0 0 0 30 0Biochemistry 6,157 2,204 0 0 0 3,453 235 0 0 0 264 0Biomat & Biomed Eng 752 505 0 125 0 0 72 0 0 27 24 0Immunology 3,952 815 0 0 0 727 395 0 947 0 1,069 0Medical Biophysics 8,731 495 18 0 0 308 0 0 2,203 0 5,707 0Medical Genetics & Microbiology 16,125 4,212 0 0 0 4,564 7,032 0 14 0 304 0Nutritional Sciences 2,124 1,054 112 0 0 52 105 798 3 0 0 0Pharmacology 1,805 1,606 0 0 57 2 0 18 119 0 4 0Physiology 6,365 3,976 0 0 0 931 0 114 0 0 1,345 0SUB-TOTAL 51,509 20,322 130 125 57 10,050 7,839 930 3,286 27 8,747 0COMMUNITY HEALTHHealth Policy, Mgmt & Eval 2,576 1,645 17 0 28 117 0 0 332 13 397 27Public Health Sciences 8,238 3,633 0 0 1,246 575 1,668 70 576 15 144 311SUB-TOTAL 10,814 5,278 17 0 1,274 692 1,668 70 908 28 541 338CLINICALAnesthesia 1,398 254 0 0 0 511 0 155 211 0 267 0Family & Community Medicine 1,009 190 0 0 246 0 194 170 209 0 0 0Lab. Medicine & Pathobiology 7,998 2,162 0 0 0 1,366 1,449 113 1,057 0 1,851 0Medical Imaging 524 20 0 0 0 135 0 0 210 0 158 0Medicine 24,067 4,103 1,242 0 67 121 2,406 3,659 3,407 16 9,010 38Obstetrics & Gynaecology 5,086 0 0 0 0 0 2,577 0 2,510 0 0 0Occupational Therapy 281 174 0 15 0 0 0 58 0 33 0 0Ophthalmology And Vision Sci 742 0 0 0 0 213 0 17 0 0 512 0Otolaryngology 249 7 0 0 0 156 0 0 86 0 0 0Paediatrics 7,270 28 0 5 0 6,913 0 0 289 34 0 0Physical Therapy 596 230 0 0 0 0 57 0 111 181 17 0Psychiatry 7,941 769 370 0 4,577 623 110 73 201 52 1,126 39Radiation Oncology 665 15 0 0 0 0 0 0 152 0 498 0Speech-Language Pathology 350 291 0 0 0 0 0 0 0 54 5 0Surgery 7,031 198 0 0 33 1,450 1,463 314 933 46 2,595 0SUB-TOTAL 65,207 8,441 1,612 20 4,923 11,488 8,256 4,559 9,376 416 16,039 77Other hospitals 1,757 648 0 0 0 1,012 31 32 0 0 35 0GRAND TOTAL 129,287 34,689 1,759 145 6,254 23,242 17,794 5,591 13,570 471 25,362 415




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8

HOSPITAL FY 2001-02 FY 2002-03 FY 2003-04 FY 2004-05 FY 2005-06 2001-2004 2002-2005 2003-2006Baycrest Centre for Geriatric Care 1,880 3,443 3,050 2,824 3,177 35.9 -9.4 2.5Bloorview MacMillab Children's Centre 1,612 1,568 1,438 656 1,044 -5.5 -31.3 2.4Centre for Addiction and Mental Health 18,540 17,358 19,961 24,140 22,255 4.3 18.0 6.6Hospital for Sick Children 55,532 53,579 59,445 55,171 85,958 3.7 1.9 24.3Mount Sinai Hospital 34,662 45,246 52,206 62,284 56,945 23.0 17.3 5.4St. Michael's Hospital 24,037 26,633 24,640 34,379 35,077 1.7 16.0 20.8SWCHSC Sunnybrook site 33,943 37,607 44,675 64,826 63,356 14.8 32.0 21.4 Orthopaeic & Arthritic site 524 257 112 . 78 -53.8 -56.6 . Women's College site 3,576 3,821 6,830 12,604 7,090 42.8 81.6 20.4Toronto Rehabilitation Institute 0.0 162.4 274.4University Health Network 65,063 85,853 106,129 120,475 118,179 27.8 18.6 5.8Other Hospitals 2 1,061 408 3,381 1,660 1,242 333.9 339.3 -38.0

SUB-TOTAL 241,731 277,017 322,921 383,655 408,717 15.6 17.7 12.7Other Locations 3 194 129 59 102 164 -44.1 9.4 67.3UofT Campus 62,048 72,152 84,045 124,342 101,602 16.4 32.2 14.8


GRAND TOTAL 6 343,812 384,483 467,488 546,586 541,682 16.7 19.3 8.0

1 Percentage represents the annual changes in funding averaged over each three year period.2 Non-affiliated hospitals and Institute of Work and Health3 Research at locations other than U of T campus or other affiliated/non-affiliated hospitals.4 The CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, Sunnybrook Site of SWCHSC, University of Toronto and the University Health Network.5 Federal Indirect Costs Program awarded to Faculty of Medicine6 Excludes Federal Indirect Costs Program awarded to affiliate hospitals.




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9


HOSPITALBaycrest Centre for Geriatric Care 1,880 3,375 2,905 2,639 2,915 32.8 -11.5 0.6Bloorview MacMillab Children's Centre 1,612 1,538 1,370 613 958 -7.8 -33.1 0.5Centre for Addiction and Mental Health 18,540 17,018 19,011 22,560 20,418 1.7 15.2 4.6Hospital for Sick Children 55,532 52,529 56,615 51,562 78,861 1.2 -0.6 22.0Mount Sinai Hospital 34,662 44,359 49,720 58,210 52,243 20.0 14.6 3.4St. Michael's Hospital 24,037 26,111 23,466 32,130 32,180 -0.8 13.4 18.5SWCHSC Sunnybrook site 33,943 36,869 42,548 60,585 58,125 12.0 28.9 19.2 Orthopaeic & Arthritic site 524 252 106 . 72 -54.9 . . Women's College site 3,576 3,746 6,505 11,779 6,504 39.2 77.4 18.1Toronto Rehabilitation Institute 1,219 1,004 4,334 13,134 -11.9 157.0 267.4University Health Network 65,063 84,170 101,075 112,594 108,421 24.7 15.7 3.8Other Hospitals 2 1,061 400 3,220 1,551 1,139 321.7 327.0 -39.2

SUB-TOTAL 241,731 271,585 307,544 358,556 374,969 12.8 14.9 10.6Other Locations 3 194 126 56 95 150 -45.4 7.1 64.2UofT Campus 62,048 70,737 80,043 116,207 93,213 13.6 29.2 12.7


GRAND TOTAL 343,812 376,945 445,227 510,828 496,956 13.9 16.4 6.0

1 Percentage represents the annual changes in funding averaged over each three year period.2 Non-affiliated hospitals and Institute of Work and Health3 Research at locations other than U of T campus or other affiliated/non-affiliated hospitals.4 The CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, Sunnybrook Site of SWCHSC, University of Toronto and the University Health Network.5 Federal Indirect Costs Program awarded to Faculty of Medicine





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10

SOURCE FY 1998-99 % FY 1999-00 % FY 2000-01 % FY 2001-02 % FY 2002-03 % FY 2003-04 % FY 2004-05 % FY 2005-06 %FEDERAL GOV.Federal Canada 62,620 26.9 70,101 28.0 89,970 31.4 109,557 35.8 131,170 37.4 144,361 35.5 186,328 36.7 192,543 37.7Federal U.S. 14,039 6.0 12,202 4.9 14,617 5.1 20,047 6.5 14,727 4.2 19,166 4.7 17,013 3.3 17,448 3.4Federal Other 118 0.1 182 0.1 14 0.0 #VALUE! . 8 0.0 0 0.0 #VALUE! . 0 0.0Sub-Total 76,777 33.0 82,485 33.0 104,601 36.5 129,603 42.3 145,906 41.6 163,528 40.2 203,341 40.0 209,990 41.1PROVINCIAL GOV.Provincial Canada 27,135 11.7 37,987 15.2 41,071 14.4 45,277 14.8 41,085 11.7 61,892 15.2 93,380 18.4 77,447 15.2Sub-Total 27,135 11.7 37,987 15.2 41,071 14.4 45,277 14.8 41,085 11.7 61,892 15.2 93,380 18.4 77,447 15.2LOCAL SOURCESLocal 8,746 3.8 7,265 2.9 8,441 2.9 10,617 3.5 15,339 4.4 18,640 4.6 26,695 5.3 32,968 6.5Internal Univ/Hosp 7,299 3.1 7,952 3.2 10,424 3.6 10,738 3.5 12,722 3.6 12,550 3.1 13,836 2.7 12,927 2.5Sub-Total 16,045 6.9 15,216 6.1 18,866 6.5 21,355 7.0 28,061 8.0 31,190 7.7 40,531 8.0 45,894 9.0INDUSTRYCanadian Industry 26,262 11.3 29,515 11.8 31,478 11.0 20,815 6.8 22,077 6.3 19,731 4.8 25,219 5.0 22,070 4.3U.S. Industry 10,975 4.7 9,195 3.7 8,555 3.0 7,612 2.5 13,111 3.7 14,515 3.6 10,297 2.0 12,273 2.4Other Foreign Ind. 1,804 0.8 1,982 0.8 1,927 0.7 1,478 0.5 1,138 0.3 11,138 2.7 2,434 0.5 4,130 0.8Sub-Total 39,040 16.8 40,692 16.3 41,960 14.7 29,905 9.8 36,327 10.3 45,384 11.1 37,950 7.5 38,473 7.5NOT-FOR-PROFITCanadian Charity 39,849 17.1 40,620 16.2 43,820 15.3 46,403 15.2 60,666 17.3 65,461 16.1 73,970 14.6 74,207 14.5Provincial Charity 9,614 4.1 10,571 4.2 12,533 4.4 12,665 4.1 15,875 4.5 14,746 3.6 16,792 3.3 17,602 3.4U.S. Charity 4,175 1.8 7,022 2.8 6,145 2.1 7,490 2.4 7,066 2.0 8,449 2.1 8,949 1.8 10,609 2.1Other Foreign Charity 981 0.4 1,252 0.5 1,779 0.6 1,925 0.6 1,550 0.4 1,675 0.4 432 0.1 384 0.1Sub-Total 54,619 23.4 59,464 23.7 64,277 22.4 68,482 22.3 85,157 24.2 90,330 22.2 100,142 19.8 102,801 20.1OTHEROther Canadian Inst. 938 0.4 2,402 1.0 2,905 1.0 2,333 0.8 1,935 0.6 1,899 0.5 5,057 1.0 6,627 1.3U.S. Institutions 2,366 1.0 2,069 0.8 2,161 0.8 1,840 0.6 2,337 0.7 1,789 0.4 8,018 1.6 6,717 1.3Other Foreign Inst. 113 0.0 153 0.1 79 0.0 231 0.1 327 0.1 248 0.1 205 0.0 384 0.1Sub-Total 3,416 1.4 4,624 1.9 5,146 1.8 4,404 1.5 4,600 1.4 3,936 1.0 13,281 2.6 13,728 2.7MISCELLANEOUSVarious Sponsors 15,869 6.8 9,791 3.9 10,283 3.6 7,181 2.3 9,769 2.8 10,764 2.6 19,473 3.8 22,142 4.3Sub-Total 15,869 6.8 9,791 3.9 10,283 3.6 7,181 2.3 9,769 2.8 10,764 2.6 19,473 3.8 22,142 4.3TOTAL 232,902 100 250,259 100 286,203 100 306,208 100 350,905 100 407,024 100 508,098 100 510,476 100CFI/OIT1 39,839 35,186 60,464 37,328 23,361Indirect Costs 2 1,160 7,837GRAND TOTAL 3 232,902 100 250,259 100 286,203 100 346,047 100 386,091 100 467,488 100 546,586 100 541,675 100Fiscal Year values represent THOUSANDS of dollars.1 The CFI and OIT funding represents infrastructure grants from Federal and Provincial sources.

3 2003-2004 value excludes $11,804,786; 2004-2005 value excludes $12,946,032; 2005-06 excludes $15,081,736 from the Federal Indirect Costs Program awarded to affiliate hospitals.




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11



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CIHR Contribution


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Research GrantsOperating Grants $415,884,882 3608Collaborative Grants $15,710,269 43Individual Group Grants $3,684,216 27Major Equipment $5,543,013 29Maintenance $767,692 16Conference Grants $2,238,177 23Travel Grants $239,453 13Techonology Transfer $293,322 2CRC Infrastructure Fund $7,007,247 25

Sub-Total $451,368,271 3786Personnel AwardsScientist, Career Investigator Awards $4,313,211 66CRC Scientists/Scholar Awards $15,766,434 110Visiting Scientist Awards $0 0Scholarship Awards $6,336,736 114Fellowship Awards $11,149,591 292Studentship Awards 1 $21,548,576 2483



GRAND TOTAL 4 $541,681,540 6878


Research Funding By Type of GrantApril 2005 to March 2006






13


StreamCareer Awards


Cross Appt with Res

Funds


Pri Appt


BASICBBDMR 22 21 1 21 10 3 5 20 4 49 28Biochemistry 33 19 14 21 18 1 15 31 15 103 31Biomat & Biomed Eng 10 7 3 73 3 5 2 12 48 4 15Immunology 28 6 24 34 5 2 4 23 16 55 25Medical Biophysics 72 0 72 70 6 0 16 56 70 296 80Medical Genetics & Microbiology 72 27 45 31 20 6 30 59 20 217 116Nutritional Sciences 24 15 9 14 6 3 3 19 unk 56 3Pharmacology 30 15 15 29 5 2 4 17 unk 49 3Physiology 45 29 16 63 16 4 16 36 unk 148 47SUB-TOTAL 336 139 199 356 89 26 95 273 173 977 348COMMUNITY HEALTHHealth Policy, Mgmt & Eval 22 22 0 125 10 4 5 24 75 71 0Public Health Sciences 262 51 211 147 20 4 15 81 unk 139 14SUB-TOTAL 284 73 211 272 30 8 20 105 75 210 14CLINICALAnesthesia 248 2 246 5 2 0 5 26 2 25 9Family & Community Medicine 766 0 766 49 1 0 2 18 13 69 1Lab. Medicine & Pathobiology 211 19 192 70 8 7 15 76 59 160 36Medical Imaging 159 2 157 19 1 0 1 13 n/a 16 9Medicine 903 33 870 74 5 0 58 290 n/a 327 154Obstetrics & Gynaecology 144 1 143 43 2 0 2 21 16 29 41Occupational Therapy 25 25 unk 1 5 3 1 14 n/a 168 n/aOphthalmology And Vision Sci 89 2 87 12 1 0 1 18 3 24 0Otolaryngology 74 0 74 24 2 0 0 4 3 3 15Paediatrics 346 0 346 29 1 0 15 123 0 133 166Physical Therapy 21 14 7 11 7 0 5 14 n/a 217 2Psychiatry 686 0 686 46 2 0 15 119 n/a 64 10Radiation Oncology 117 0 117 6 0 0 3 21 3 23 24Speech-Language Pathology 10 10 0 6 5 3 1 10 3 129 1Surgery 326 7 319 58 3 0 14 123 unk 145 87SUB-TOTAL 4,125 115 4,010 453 45 13 138 890 102 1,532 555TOTAL 4,745 327 4,420 1,081 164 47 253 1,268 350 2,719 917Based on data received from each individual Department


Research Personnel by DepartmentApril2005 - March 2006

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14




Prim Appt


FellowsBaycrest Centre for Geriatric Care 13 3 4 7Bloorview MacMillan Children's Centre 11 2 1 0Centre for Addiction and Mental Health 78 15 29 14Hospital for Sick Children 249 49 247 265Mount Sinai Hospital 112 20 102 66St. Michael's Hospital 165 21 103 37SWCHSC 37 Sunnybrook site 108 22 62 no breakdown Orthopaeic & Arthritic site 1 0 0 no breakdown Women's College site 22 2 3 no breakdownToronto Rehabilitation Institute 19 1 14 11University Health Network 299 52 462 368TOTAL 1077 187 1027 805Hospital Post-doc numbers based on data provided by each individual hospital

April2005 - March 2006



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15

DEPARTMENT Sq. Meters

BASICAnatomy & Cell Biology n/aBanting and Best Department of Medical Research 3,270Biochemistry 1,910Institute of Biomaterials & Biomedical Engineering 1 63Immunology 827Medical Biophysics n/aMedical Genetics & Microbiology 2,276Nutritional Sciences 1,009Pharmacology 1,633Physiology 1,982

Sub-Total 12,970COMMUNITY HEALTHHealth Policy, Management & Evaluation 464Public Health Sciences 1,867

Sub-Total 2,331CLINICALAnesthesia n/aFamily & Community Medicine n/aLab. Medicine & Pathobiology 1,447Medical Imaging n/aMedicine 157Obstetrics & Gynaecology n/aOccupational Therapy 652Ophthalmology And Vision Science 563Otolaryngology n/aPaediatrics n/aPhysical Therapy 810Psychiatry n/aRadiation Oncology n/aSpeech-Language Pathology 577Surgery (includes Anatomy Div.) 334

Sub-Total 4,540OTHERBiomedical Communications 69Centre for Research in Neurodegeneratice Disease 1,251Clinical Sciences Division Common Lab Space 3,108Comparative Medicine 2,280Common Research Space 1,933Heart & Stroke / Richard Lewar Centre for Excellence… 321Rehabilitation Sciences Sector 135Structural Genomics Consortium 1,223


Based on a data extracted on: July, 20061 Includes ONLY IBBME research space at the MSB

Table 9




16




External - Other $829,305.67 $3,457,653.44 $4,286,959.11


Internal - U of T $11,858,637.55 $2,456,283.11 $14,314,920.66

Grand Total $20,872,922.32 $14,838,449.51 $35,711,371.83

1 From data provided byOffice of the Vice Dean, Graduate Affairs

Type of Funding



September 1, 2005 - August 31, 2006

Synopsis of R



17

Graduate Unit AWARD STIPEND Grand TotalBiochemistry $1,285,605.28 $1,463,688.55 $2,749,293.83Graduate Department of Rehabilitation Science $466,427.24 $223,622.63 $690,049.87Health Policy, Management & Evaluation $718,301.29 $1,092,059.08 $1,810,360.37Immunology $821,163.26 $402,706.79 $1,223,870.05Institute of Biomaterials & Biomedical Engin. $706,491.16 $523,374.50 $1,229,865.66Institute of Medical Science $5,408,653.21 $3,204,614.26 $8,613,267.47Laboratory Medicine & Pathobiology $1,350,694.46 $1,344,235.38 $2,694,929.84Medical Biophysics $2,525,916.46 $1,193,762.86 $3,719,679.32Molecular & Medical Genetics $1,872,748.81 $1,922,784.69 $3,795,533.50Nutritional Sciences $675,818.92 $308,397.72 $984,216.64Occupational Health $303,346.96 $0.00 $303,346.96Pharmacology $701,213.13 $970,987.66 $1,672,200.79Physical Therapy $407,326.68 $0.00 $407,326.68Physiology $1,380,356.44 $1,712,934.47 $3,093,290.91Public Health Sciences $1,571,658.14 $425,085.89 $1,996,744.03Speech-Language Pathology $677,200.88 $50,195.03 $727,395.91

Grand Total $20,872,922.32 $14,838,449.51 $35,711,371.831 From data provided byOffice of the Vice Dean, Graduate Affairs

Type of Funding




Synopsis of R



18

Awards Stipend1

Baycrest/Rotman Institute $140,000.00 $46,400.00 $186,400.00Bloorview Macmillan Centre $0.00 $0.00 $0.00Centre for Addiction and Mental Health $406,500.00 $292,551.00 $699,051.00Hospital For Sick Children $1,532,549.93 $1,575,406.31 $3,107,956.24Mount Sinai Hospital $148,495.00 $722,717.26 $871,212.26St. Michael's Hospital $283,000.00 $309,680.72 $592,680.72Sunnybrook & Women's College Health Science Centre $519,850.00 $564,255.01 $1,084,105.01Toronto Rehabilitation Institute $0.00 $0.00 $0.00University Health Network $1,623,681.00 $1,163,092.15 $2,786,773.15

$0.00 $0.00 $0.00Other $125,666.66 $126,733.00 $252,399.66

Off Campus Total $4,779,742.59 $4,800,835.45 $9,580,578.04

UofT Fellowship OtherUniversity of Toronto $4,544,061.99 $3,838,824.95 $6,138,614.44 $10,037,614.06 $24,559,115.44



OSOTF Total2 $1,571,678.35 Grand Total $35,711,371.83Notes:1 Stipend from Supervisor's Research Grant (sources Internal or External to the Institution)2 Matched Funding (1/3 Donation from Hospital Foundation; 1/3 Ontario Government; 1/3 University of Toronto 3 From data provided byOffice of the Vice Dean, Graduate Affairs

Internal (On campus)

Administrative Site Description Total (not including OSOTF below)




External (Off campus)

Synopsis of R



19




20

FACULTY OF MEDICINE – UNIVERSITY OF TORONTO ALL DEPARTMENTS: 2005-2006 Total Research Funding: $541,681,5401

Total Number of Awards: 6878 Canadian Institutes of Health Research (CIHR) $123,650,570 Natural Sciences and Engineering Research Council (NSERC) $6,146,943 National Cancer Institute of Canada (NCIC) $23,715,546 Health Canada (HLTH CAN) $3,754,556 Ontario Ministry of Health (MOH) $22,107,546 Heart and Stroke Foundation of Ontario/Canada (HSFO/C) $13,292,102 Social Sciences & Humanities Research Council (SSHRC) $1,134,893 Industry Sources $38,472,840 Other Sources $309,406,545 Total Number of Academic Staff: Primary Appointments $4,745 On Campus $327 Off Campus $4,420 Cross Appointments $1,081 Tenured $164 Tenure-stream $47 Career Awards $253 Primary Appointments with Research Awards $1,268 Fellows: Post-Doctoral and Clinical Research Fellows $537 Based on data received from individual Departments



21




Overall Research Objective : To develop the environment and recruit personnel for research of the highest quality necessary for the advancement of knowledge in the areas of interest to Anesthesia. Current Major Areas of Research ::Faculty in the Department of Anesthesia have developed research interests and programs in a number of fields related to pain management and peri-operative care. These include the following major areas, each represented by an identified contact person. Acute Pain C. McCartney 603-5118 [email protected] Ambulatory Anesthesia F. Chung 603-5118 [email protected] Anesthesia mechanisms B. Orser 480-4864 [email protected] Blood Conservation K. Karkouti 340-5164 [email protected] Cardiovascular D. Mazer 864-5825 [email protected] Critical Care B. Kavanagh 813-8019 [email protected] Malignant Hyperthermia J. Loke 340-3128 [email protected] Neuroscience B. Orser 480-4864 [email protected] Obstetrical Management S. Halpern 323-6008 [email protected] Outcomes Research S. Beattie 340-5164 [email protected] Paediatrics M. Crawford 813-7445 [email protected] Pain mechanisms D. Joo 813-7445 [email protected] Regional Anesthesia V. Chan 340-3227 [email protected] Simulation P.Morgan 323,6269 [email protected] V. Naik 864-5071 [email protected] - Text last updated March 2007


22



Total Number of Awards: 124 Primary Appointments 22 On Campus 21 Off Campus 1 Cross Appointments 21 CIHR $7,185,225 Tenured 10 NSERC $208,163 Tenure-stream 3 NCIC $1,006,256 Career Awards 5 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 20 HSFO/C $135,499 Cross Appointments 4 SSHRC $0 Studentship Awards: Industry $9,424 Supervised by Primary Appt 49 Other Sources $14,139,702 Fellows: Post-Doc. and Clin. 28

Overall Research Objective : To use proteomics, functional genomics and bioinformatics to achieve a comprehensive view of gene function, cell regulatory pathways and gene/protein networks. To understand the molecular basis of biological disorders. Current Major Areas of Research : • Cell cycle • Control of gene expression • Developmental biology • Functional genomics • Mechanism of action of hormones • Membrane structure and function • Muscle biology • Proteomics • Structural biology - Text last updated March 2007


23



Total Number of Awards: 226 Primary Appointments 33 On Campus 19 Off Campus 14 Cross Appointments 21 CIHR $5,339,337 Tenured 18 NSERC $617,947 Tenure-stream 1 NCIC $1,155,115 Career Awards 15 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 31 HSFO/C $364,353 Cross Appointments 15 SSHRC $11,732 Studentship Awards: Industry $384,643 Supervised by Primary Appt 103 Other Sources $6,351,338 Fellows: Post-Doc. and Clin. 31

Overall Research Objective : To advance and disseminate our understanding of the molecular fundamentals of life through first rate research and academic programs. Current Major Areas of Research : • Biomolecular structure and function • Gene expression and development • Membranes and transport • Molecular cell biology • Molecular medicine • Protein folding • Proteomics and Bioinformatics • Signal transduction and regulation - Text last updated March 2007


24



Total Number of Awards: 106 Primary Appointments 766 On Campus 0 Off Campus 766 Cross Appointments 49 CIHR $691,938 Tenured 1 NSERC $0 Tenure-stream 0 NCIC $0 Career Awards 2 HLTH CAN $2,306,443 With Research Funds MOH $1,054,933 Primary Appointments 18 HSFO/C $68,462 Cross Appointments 13 SSHRC $5,834 Studentship Awards: Industry $37,030 Supervised by Primary Appt 69 Other Sources $1,066,883 Fellows: Post-Doc. and Clin. 1


genetics, care of the elderly, prescribing and care of people with chronic disabling conditions • Improving population access to primary care - Text last updated March 2007


25



Total Number of Awards: 133 Primary Appointments 22 On Campus 22 Off Campus 0 Cross Appointments 125 CIHR $2,506,078 Tenured 10 NSERC $0 Tenure-stream 4 NCIC $0 Career Awards 5 HLTH CAN $130,807 With Research Funds MOH $1,773,884 Primary Appointments 24 HSFO/C $0 Cross Appointments 75 SSHRC $67,193 Studentship Awards: Industry $2,048 Supervised by Primary Appt 71 Other Sources $3,257,766 Fellows: Post-Doc. and Clin. 0

Overall Research Objective : To contribute to knowledge, thereby advancing the discipline, improving teaching and improving the theory and practice of health services management and administration and clinical epidemiology. To educate researchers through the M.Sc./Ph.D. program and to foster an appreciation of the methods and application of health services research among graduate students. Current Major Areas of Research : • Clinical evaluative sciences • Financing of health services • Health measurement • Health care improvement • Health performance assessment • Health policy and economics • Organizational research • Outcomes research • Program planning and evaluation - Text last updated March 2007


26






27


Total Research Funding: 1 Academic Staff:

Fac of Med primary appointments $2,577,566 Primary Appointments 10 On Campus 7 Total Number of Awards: 34 Off Campus 3 Cross Appointments 73 CIHR $1,004,252 Tenured 3 NSERC $91,915 Tenure-stream 5 NCIC $0 Career Awards 2 HLTH CAN $0 With Research Funds MOH $397,900 Primary Appointments 12 HSFO/C $0 Cross Appointments 48 SSHRC $0 Studentship Awards: Industry $340,263 Supervised by Primary Appt 4 Other Sources $743,236 Fellows: Post-Doc. and Clin. 15






Departmental Web-site is http://www.utoronto.ca/IBBME - Text last updated March 2007



28



Total Number of Awards: 402 Primary Appointments 211 On Campus 19 Off Campus 192 Cross Appointments 70 CIHR $7,336,435 Tenured 8 NSERC $1,038,090 Tenure-stream 7 NCIC $1,404,201 Career Awards 15 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 76 HSFO/C $1,893,623 Cross Appointments 59 SSHRC $0 Studentship Awards: Industry $3,698,798 Supervised by Primary Appt 160 Other Sources $8,826,421 Fellows: Post-Doc. and Clin. 36




atherosclerosis, ischemic heart disease, lipid disorders, and valvular disease - Text last updated March 2007


29



Total Number of Awards: 539 Primary Appointments 72 On Campus 0 Off Campus 72 Cross Appointments 70 CIHR $7,543,576 Tenured 6 NSERC $657,730 Tenure-stream 0 NCIC $8,708,597 Career Awards 16 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 56 HSFO/C $570,827 Cross Appointments 70 SSHRC $0 Studentship Awards: Industry $1,770,286 Supervised by Primary Appt 296 Other Sources $45,951,712 Fellows: Post-Doc. and Clin. 80


- Text last updated March 2007


30



Total Number of Awards: 504 Primary Appointments 72 On Campus 27 Off Campus 45 Cross Appointments 31 CIHR $14,289,655 Tenured 20 NSERC $768,362 Tenure-stream 6 NCIC $4,119,893 Career Awards 30 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 59 HSFO/C $189,302 Cross Appointments 20 SSHRC $0 Studentship Awards: Industry $1,158,549 Supervised by Primary Appt 217 Other Sources $37,407,231 Fellows: Post-Doc. and Clin. n/a

Overall Research Objective : The mission of the Department of Medical Genetics & Microbiology/Graduate Department of Molecular & Medical Genetics is to conduct world-class research and to train outstanding students in several cutting-edge research areas. Molecular biological, molecular genetic, cellular and systems biological approaches are applied tto studies in six research areas: 1) functional genomics and proteomics; 2) molecular biology and macromolecular structure; 3) molecular medicine and human genetics; 4) model organism genetics and genetic control of development; 5) cell biology and signal transduction; 6) systems biology, computational biology and bioinformatics; and 7) molecular microbiology, virology and infectious disease research. Our aims are to: 1. Establish and/or maintain internationally competitive research programs in the areas listed above; 2. train future generations of independent scientists. Current Major Areas of Research : Signal transduction and cell regulation - Cell cycle and growth control - Transcriptional and post-transcriptional regulation of gene expression - Epigenetics and chromatin regulation - Chromosome dynamics and biology - Functional genomics - Nucleic acid metabolism and function - Structural biology using X-ray crystallography and NMR spectroscopy - Proteomics - Systems biological and bioinformatic analysis of gene regulatory networks, protein interaction networks, cell cycle and development - Analyses of complex genetic disease and single gene disorders - Disease gene mapping and identification - Genome annotation - Cell biology and developmental biology of disease states - Human chromosome structure, function and dynamics - Molecular diagnostics and gene therapy - Yeast, worm, fly, zebrafish, frog and mouse models of development - Stem cell research and haematopoiesis - Neurogenesis and neurobiology - Host-pathogen (viral, bacterial, fungal) interaction - Viral and plasmid segregation - Viral RNA transport and processing Departmental Website: http://www.utoronto.ca/medicalgenetics/ - Text last updated February 2007


31



Total Number of Awards: 38 Primary Appointments 159 On Campus 2 Off Campus 157 Cross Appointments 19 CIHR $383,112 Tenured 1 NSERC $24,833 Tenure-stream 0 NCIC $0 Career Awards 1 HLTH CAN $0 With Research Funds MOH $579,442 Primary Appointments 13 HSFO/C $0 Cross Appointments n/a SSHRC $11,667 Studentship Awards: Industry $526,549 Supervised by Primary Appt 16 Other Sources $8,168,134 Fellows: Post-Doc. and Clin. n/a

Overall Research Objective : Characterization of the structure and function of normal and diseased tissue using all modern imaging methods. Physiologically specific imaging at the metabolic, cellular, vascular and tissue level, using MRS, PET, MRI and MEG. Current Major Areas of Research : • Clinical trials of new contrast agents and drugs • Design of new imaging techniques and imaging systems • Integration of imaging data • Magnetic resonance imaging and spectroscopy • MEG and MSI • Minimally invasive diagnosis and therapy • Molecular imaging • Percutaneous and transvascular treatment methods • PET/CT • Picture archival and communications systems (PACS) • Real-time imaging • Tissue characterization by imaging - Text last updated March 2007


32



Total Number of Awards: 1409 Primary Appointments 903 On Campus 33 Off Campus 870 Cross Appointments 74 CIHR $24,114,609 Tenured 5 NSERC $270,743 Tenure-stream 0 NCIC $2,556,513 Career Awards 58 HLTH CAN $550,590 With Research Funds MOH $1,149,680 Primary Appointments 290 HSFO/C $5,310,075 Cross Appointments n/a SSHRC $219,705 Studentship Awards: Industry $16,444,170 Supervised by Primary Appt 327 Other Sources $52,985,227 Fellows: Post-Doc. and Clin. n/a












osteoporosis, musculoskeletal disease in the community & work force. - Text last updated March 2007


33



Total Number of Awards: 122 Primary Appointments 24 On Campus 15 Off Campus 9 Cross Appointments 14 CIHR $1,457,405 Tenured 6 NSERC $755,292 Tenure-stream 3 NCIC $213,204 Career Awards 3 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 19 HSFO/C $18,000 Cross Appointments unk SSHRC $35,000 Studentship Awards: Industry $877,864 Supervised by Primary Appt 56 Other Sources $1,461,949 Fellows: Post-Doc. and Clin. 3

Overall Research Objective : To advance the health of the population through basic, clinical and community aspects of human nutrition. Current Major Areas of Research : Bone Health W. E.Ward 946-7366 [email protected] Carbohydrate/Fibre T. Wolever 978-5556 [email protected] Metabolism Community and V. Tarasuk 978-0618 [email protected] Public Health Nutrition Diabetes and D. Jenkins 978-4752 [email protected] Cardiovascular Disease Diet and Cancer M.C. Archer 978-8195 [email protected] Food Intake Regulation G.H. Anderson 978-1832 [email protected] and Obesity Functional Foods and V. Vuksan 864-5525 [email protected] Nutriceuticals Lipid Metabolism R. Bazinet 946-8276 [email protected] Nutrigenetics and A. El-Sohemy 946-5776 [email protected] Nutrigenomics Nutrition and Brain Function/ C. Greenwood 978-4261 [email protected] Behaviour Nutrition in Diseased P. Darling 864-5535 [email protected] Populations Nutritional Toxicology M.C. Archer 978-8195 [email protected] Paediatric Nutrition D. O’Connor 813-7844 deborah_l.o’[email protected] Protein and Amino Acid P. Pencharz 813-6169 [email protected] Metabolism Vitamin and Mineral W. E. Ward 946-7366 [email protected] Metabolism Departmental Web-site is http://www.utoronto.ca/nutrisci/depthome.htm - Text last updated March 2007


34




Overall Research Objective : To achieve International recognition as a centre of excellence in women’s health research Current Major Areas of Research : • Clinical and basic perinatology • Control of parturition • Gynecologic cancers • Health services and health outcomes • Medical education • Minimally-invasive surgery • Molecular control of early fetal and placental growth • Multicentre perinatal randomized controlled trials • Paediatric and adolescent gynecology • Reproductive biology • Urogynecology and pelvic floor disorders • Developmental origins of adult health and disease - Text last updated March 2007


35

DEPARTMENT: Occupational Science & Occupational Therapy Total Research Funding: $1,664,750 Academic Staff:

Total Number of Awards: 196 Primary Appointments 25 On Campus 25 Off Campus unk Cross Appointments 1 CIHR $243,310 Tenured 5 NSERC $13,500 Tenure-stream 3 NCIC $0 Career Awards 1 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 14 HSFO/C $0 Cross Appointments n/a SSHRC $123,173 Studentship Awards: Industry $57,000 Supervised by Primary Appt 168 Other Sources $1,227,767 Fellows: Post-Doc. and Clin. n/a Overall Research Objective : The Department of Occupational Science and Occupational Therapy will focus its science on advancing the knowledge of occupation and its enablement. The systematic study of daily occupations and their meanings in the lives of people of all ages and abilities will serve to improve the life and well being of individuals, families, groups, communities and societies, breaking through barriers encountered in all aspects of daily living. Current Major Areas of Research :


Fieldwork education and adult rehabilitation Measurement and muskuloskeletal function Independent living, outcome measures, quality of life, environmental influences, social integration & spinal cord injury

D. Cameron J. Cameron K. Campbell H. Carnahan

Play and playfulness, fieldwork, parenting styles, cognitive strategies in preschoolers Research enables and supports family members who take on the care-giving role for individuals with disabilities. Pediatric rehabilitation, technology and disability Sensory inputs in performance of skilled hand movements, motor control & learning theory applications.

T. Chiu Home care service and technology and aging L. Cockburn Professional education, teaching and curricula development, participatory research, mental health and mental health

promotion, history of occupational therapy, transcultural and diversity issues A. Colantonio J. Davis


D. Dawson Outcomes following acquired brain injury, psychosocial influences on cognition, cognitive rehabilitation, integrating spirituality into OS & OT curricula

S. Farrow Psychological implications of illness, group process and therapy; inter-professional education A. Fourt Mental health issues and reform, women’s issues J. Friedland Psychosocial adjustment to illness and disability, effects of social support and coping on quality of life of people with

disabilities, history of occupational therapy and rehabilitation S. Friefeld Quality of life in children with disabilities, sensory-motor learning and adaptation D. Hebert M. Iwama M. Keightley

Attention, apraxia, unilateral neglect, neurology, fieldwork Culture and occupation Traumatic Brain Injury in Children and Youth; Acquired Brain Injury in Aboriginal populations





R. Stack Fieldwork education and assessment - Text last updated February 2007


36



Total Number of Awards: 86 Primary Appointments 89 On Campus 2 Off Campus 87 Cross Appointments 12 CIHR $859,093 Tenured 1 NSERC $26,000 Tenure-stream 0 NCIC $148,408 Career Awards 1 HLTH CAN $0 With Research Funds MOH $1,067,148 Primary Appointments 18 HSFO/C $21,000 Cross Appointments 3 SSHRC $0 Studentship Awards: Industry $562,304 Supervised by Primary Appt 24 Other Sources $2,233,392 Fellows: Post-Doc. and Clin. 0



37



Total Number of Awards: 11 Primary Appointments 74 On Campus 0 Off Campus 74 Cross Appointments 24 CIHR $189,951 Tenured 2 NSERC $21,000 Tenure-stream 0 NCIC $0 Career Awards HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 4 HSFO/C $0 Cross Appointments 3 SSHRC $0 Studentship Awards: Industry $0 Supervised by Primary Appt 3 Other Sources $248,431 Fellows: Post-Doc. and Clin. 15

Overall Research Objective : To further our basic understanding of the inner ear, upper respiratory tract, and disorders of the neck and skull base. Current Major Areas of Research : • Auditory physiology and pathophysiology • Cochlear implants: basic and applied issues • Head and neck oncology: treatment and epidemiology • Hearing loss and associated communication disorders • Laryngeal cancer histopathology • Neonatal hearing loss • Psychoacoustics • Temporal bone histopathology • Upper respiratory tract • Vestibular and oculomotor topics: clinical and basic - Text last updated March 2006


38



Total Number of Awards: 482 Primary Appointments 346 On Campus 0 Off Campus 346 Cross Appointments 29 CIHR $7,395,673 Tenured 1 NSERC $47,322 Tenure-stream 0 NCIC $561,485 Career Awards 15 HLTH CAN $444,655 With Research Funds MOH $61,125 Primary Appointments 123 HSFO/C $889,484 Cross Appointments 0 SSHRC $0 Studentship Awards: Industry $2,966,769 Supervised by Primary Appt 133 Other Sources $15,488,402 Fellows: Post-Doc. and Clin. 166

Overall Research Objective : To study mechanisms of disease and health maintenance in infants and children utilizing molecular, biochemical and epidemiological methods. Current Major Areas of Research : • Brain and behavioural research • Cancer and blood research • Cardiovascular research • Cell biology • Developmental biology • Genetics and genomic biology • Infection, immunity, injury and repair research • Integrative biology • Metabolic research • Population health science • Structural biology and biochemistry - Text last updated March 2007


39




HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 17 HSFO/C $68,860 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $199,743 Supervised by Primary Appt 49 Other Sources $3,711,309 Fellows: Post-Doc. and Clin. 3

Overall Research Objective : To investigate and understand the interaction of chemical compounds with living systems. To strengthen the department through the development of research related to the mechanisms of drug action and toxicity. Current Major Areas of Research : • Behavioural pharmacology and drug addiction • Biochemical and molecular pharmacology • Clinical pharmacology • Drug metabolism and distribution • Drug safety and toxicology • Neuropharmacology and psychopharmacology • Pharmacogenetics • Receptor pharmacology • Second messengers and signal transduction - Text last updated March 2007



40



Total Number of Awards: 249 Primary Appointments 21 On Campus 14 Off Campus 7 Cross Appointments 11 CIHR $432,139 Tenured 7 NSERC $55,991 Tenure-stream 0 NCIC $0 Career Awards 5 HLTH CAN $0 With Research Funds MOH $413,544 Primary Appointments 14 HSFO/C $116,669 Cross Appointments n/a SSHRC $5,833 Studentship Awards: Industry $0 Supervised by Primary Appt 217 Other Sources $1,502,476 Fellows: Post-Doc. and Clin. 2


continuum care - Text last updated March 2007


41



Total Number of Awards: 273 Primary Appointments 45 On Campus 29 Off Campus 16 Cross Appointments 63 CIHR $5,487,358 Tenured 16 NSERC $492,821 Tenure-stream 4 NCIC $0 Career Awards 16 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 36 HSFO/C $1,135,849 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $31,988 Supervised by Primary Appt 148 Other Sources $5,834,165 Fellows: Post-Doc. and Clin. 47

Overall Research Objective : Key Priorities: a) To expand and enrich four key areas of basic research represented by our Platforms of Research (see below) and to integrate these basic research activities into the clinical and basic research objectives of our sister hospital based research institutions. A “research partnership” is defined as a mutually beneficial collaborative research link which includes sharing of personnel and resources between the Department of Physiology on one hand and another Research unit within the University of Toronto/ Health Care Research community b) An important aspect of our research partnerships is to provide an outstanding environment for postdoctoral and graduate trainees c) An important aspect of our research partnerships is to provide an outstanding environment for the basic science training of clinician scientists d) A key priority of our research efforts is aimed at providing specialized undergraduate teaching to Arts and Sciences students with the objective of attracting the very best candidate for graduate level training in the Faculty of Medicine Key Challenges: a) To develop strategies that define academic and research partnerships between Departmental Research Platforms and other organizations within the University of Toronto/ Health Care Complex b) To expand competitive funding for research and training initiatives involving members of the Department of Physiology and our active research partners c) To recruit top research scientists to the full extent of our fiscal and physical resources and to maintain the Department of Physiology at the leading edge of international research. To maintain and enhance the infrastructure support from sources external to the direct budget of the Department Current Major Areas of Research : The following describes our plans for introduction of Research Platforms with sub-interest groups. Proposed Research Platforms: 1. Cardiovascular & Respiratory Science: http://www.uoftphysiology.com/faculty/programs/divisionDetails.cfm?division=6&from=listing 2. Endocrinology & Diabetes: http://www.uoftphysiology.com/faculty/programs/divisionDetails.cfm?division=5&from=listing 3. Brain & Behaviour: The Neurosciences: http://www.uoftphysiology.com/faculty/programs/divisionDetails.cfm?division=7&from=listing 4. Reproduction and Development: http://www.uoftphysiology.com/faculty/programs/divisionDetails.cfm?division=9&from=listing - Text last updated March 2007


42






43



Total Number of Awards: 367 Primary Appointments 262 On Campus 51 Off Campus 211 Cross Appointments 147 CIHR $7,420,356 Tenured 20 NSERC $295,718 Tenure-stream 4 NCIC $523,538 Career Awards 15 HLTH CAN $268,462 With Research Funds MOH $6,883,394 Primary Appointments 81 HSFO/C $205,906 Cross Appointments unk SSHRC $241,284 Studentship Awards: Industry $445,150 Supervised by Primary Appt 139 Other Sources $8,734,310 Fellows: Post-Doc. and Clin. unk


infectious disease, chronic disease(eg. Arthritis, diabetes), accidents and injuries • Gerontology health and aging • Health professions and organizations • Health promotion and disease prevention • Methodological research in epidemiology, biostatistics and demography • Methodology: qualitative, quantitative, evaluation • Occupational and environmental health • Prevention of transmission of HIV/AIDS - Text last updated March 2007


44



Total Number of Awards: 79 Primary Appointments 117 On Campus 0 Off Campus 117 Cross Appointments 6 CIHR $862,515 Tenured 0 NSERC $64,334 Tenure-stream 0 NCIC $1,177,236 Career Awards 3 HLTH CAN $0 With Research Funds MOH $119,500 Primary Appointments 21 HSFO/C $0 Cross Appointments 3 SSHRC $0 Studentship Awards: Industry $1,109,024 Supervised by Primary Appt 23 Other Sources $4,896,130 Fellows: Post-Doc. and Clin. 24

Overall Research Objective : Excellence in clinical and translational, basic science, and physics and imaging research related to radiation medicine. Current Major Areas of Research : • Molecular radiation biology of tumour and normal tissues • Image guided radiation therapy • Clinical trials • Tumour microenvironment and treatment outcome • Health services research For more information about the Department of Radiation Oncology contact: Dr. Anthony Fyles 416-946-6522 [email protected] - Text last updated March 2007


45



Total Number of Awards: 149 Primary Appointments 10 On Campus 10 Off Campus 0 Cross Appointments 6 CIHR $354,444 Tenured 6 NSERC $22,930 Tenure-stream 3 NCIC $0 Career Awards 1 HLTH CAN $19,000 With Research Funds MOH $0 Primary Appointments 10 HSFO/C $111,130 Cross Appointments 3 SSHRC $87,051 Studentship Awards: Industry $12,000 Supervised by Primary Appt 129 Other Sources $1,042,946 Fellows: Post-Doc. and Clin. 1

Overall Research Objective : To advance knowledge of the neurological, behavioural, and social aspects of communication and swallowing. There are two primary foci: normal and disordered speech and swallowing, and language development and disorders across the lifespan. Research linkages have been forged through collaborative projects with engineering, neurological imaging, dentistry, linguistics, psychiatry and gastroenterology among others. Another research objective is to develop improved models of clinical management of communication disorders. Clinical research is being undertaken in the areas of augmentative and alternative communication, speech fluency, developmental language disorders, hearing loss, acquired aphasia and apraxia of speech among others. Current Major Areas of Research : Members of the Graduate Department of Speech-Language Pathology pursue research in the following major areas, each represented by a contact person identified below. For more information about our three graduate programs and a detailed list of faculty and their research, please inquire at 500 University Avenue, 10th Floor. Motor speech disorders and swallowing C. Steele 978-8330 Developmental speech and language disorders L. Girolametto 978-3353 Acquired language disorders (aphasia and dementia) E. Rochon 978-8332 C. Leonard 978-8332 Voice and resonance disorders T. Bressmann 978-7088 Speech motor control and stuttering L. De Nil 978-1789 Augmentative and alternative communication B. O’Keefe 978-6890 Developmental speech and language disorders C. Johnson 978-8331 Speech physiology and speech motor control P. Van Lieshout 978-8334 Childhood hearing loss A. Eriks-Brophy 946-8633 Swallowing R. Matino 946-8644 Stuttering R. Kroll 978-1789 International Rehabilitation P. Parnes 946-8556 Aphasia Treatment Outcomes A. Kagan 978-2770 - Text last updated March 2007


46

DEPARTMENT: Surgery


Total Number of Awards: 500 Primary Appointments 326 On Campus 7 Off Campus 319 Cross Appointments 58 CIHR $7,406,608 Tenured 3 NSERC $225,534 Tenure-stream 0 NCIC $1,153,845 Career Awards 14 HLTH CAN $0 With Research Funds MOH $819,500 Primary Appointments 123 HSFO/C $1,568,501 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $4,078,796 Supervised by Primary Appt 145 Other Sources $23,689,124 Fellows: Post-Doc. and Clin. unk

Overall Research Objective : Development of excellence in research programs including the training of Surgeon-Scientists. Current Major Areas of Research : • Cardiovascular diseases • Clinical epidemiology and result of treatment outcomes of disorders treated by surgeons • Ischemia and reperfusion of skin, skeletal muscle, heart and lungs • Neurosciences: spinal, spinal cord and nerve repair • Oncology: basic and surgical aspects • Organ transplantation and preservation • Surgical education: technical skill assessment and acquisition • Surgical infections/critical care • The pathophysiology and treatment of trauma • The pathophysiology of diseases of clinical interest of surgeons • Development of experimental models of surgical diseases (e.g., genetically modified mice) • Analysis of new therapies • Research into cellular mechanisms in repair and regeneration • Engineering and computing technology in surgery • Improving knowledge transfer and quality of care in Canada and abroad (including Third

World countries) - Text last updated March 2007

1 FMRO-calculated values presented. Department-provided numbers are as follows: Total Research Funding: $45,245,894; Total Awards: 480; CIHR: $8,978,057; NSERC: $219,725; NCIC: $2,194,400; OMHLTC: $ 760,375; HSFO/C: $1,682,505; Industry: $10,181,664; Other Sources: $21,229,168


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48

FACULTY OF MEDICINE – UNIVERSITY OF TORONTO AFFILIATED TEACHING HOSPITALS: 2005-2006







49



Total Number of Awards: 31 Research Funds 13 Career Awards 3 CIHR $1,655,692 Studentship Grant Awards: NSERC $53,500 NCIC $0 Supervised by Investigator 4 HLTH CAN $0 MOH $74,077 Fellows: HSFO/C $450,835 SSHRC $198,778 Post-Doc. and Clin. 7 Industry $0 Other Sources $743,958



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Total Number of Awards: 23 Research Funds 11 Career Awards 2 CIHR $102,751 Studentship Grant Awards: NSERC $60,415 NCIC $0 Supervised by Investigator 1 HLTH CAN $0 MOH $0 Fellows: HSFO/C $0 SSHRC $0 Post-Doc. and Clin. 0 Industry $547,264 Other Sources $333,452



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Total Number of Awards: 238 Research Funds 78 Career Awards 15 CIHR $4,961,361 Studentship Grant Awards: NSERC $4,500 NCIC $18,120 Supervised by Investigator 29 HLTH CAN $2,009,028 MOH $4,126,774 Fellows: HSFO/C $52,374 SSHRC $249,755 Post-Doc. and Clin. 14 Industry $1,604,282 Other Sources $9,228,963



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53



Total Number of Awards: 517 Research Funds 112 Career Awards 20 CIHR $17,167,567 Studentship Grant Awards: NSERC $869,526 NCIC $3,310,712 Supervised by Investigator 102 HLTH CAN $0 MOH $843,808 Fellows: HSFO/C $685,343 SSHRC $0 Post-Doc. and Clin. 66 Industry $5,851,562 Other Sources $28,216,588



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Total Number of Awards: 709 Research Funds 165 Career Awards 21 CIHR $6,369,904 Studentship Grant Awards: NSERC $359,188 NCIC $27,339 Supervised by Investigator 103 HLTH CAN $442,665 MOH $202,250 Fellows: HSFO/C $837,348 SSHRC $20,927 Post-Doc. and Clin. 37 Industry $8,281,988 Other Sources $18,535,078

Overall Research Objective: The St. Michael's Hospital Research Centre’s goal is to reflect the hospital’s longstanding mission of caring for the most critically ill and vulnerable populations. This mission is achieved through defined research foci in critical care/cell injury, inner city health, global health and knowledge translation. Current Major Areas of Research: Critical Care Research: The critical care research matrix is comprised of three cross-cutting themes in regenerative medicine, inflammation/injury and molecular and genetic determinants of disease. These themes cross clinical specializations in vascular biology, trauma/respiratory failure, diabetes/kidney and blood research, which together form a comprehensive program in basic and clinical research. Inner City Health Research: The Centre for Research on Inner City Health is the first research centre of its kind in Canada whose mission is to improve the health of urban populations through a program of policy relevant research. Particular emphasis is placed on the needs of socially disadvantaged and economically deprived groups, including the homeless and underhoused, those suffering from mental illness and patients diagnosed with diseases including HIV/AIDS and tuberculosis. Global Health Research: The program in global health includes the Centre for Global Health Research which is focused on large scale epidemiology with emphasis on conducting research in India. Global health researchers are also focused on broader issues including international bioethics, infectious diseases in immigrant populations, HIV/AIDS intervention and prevention in Africa and health systems reform in China. Knowledge Translation (KT): The focus of KT is to identify the best methods of integrating proven research evidence into the activity of health-care professionals and policy makers and to ultimately provide the most appropriate service to patients and communities. Specific areas of focus within KT Research include; Using the hospital and clinics as a living laboratory, KT in the developing world, and community and citizen engagement. - Text last updated March 2007


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HOSPITAL: Sunnybrook & Women’s College Health Sciences Centre Orthopaedic and Arthritic Site


Total Number of Awards: 1 Research Funds 1 Career Awards 0 CIHR $0 Studentship Grant Awards: NSERC $0 NCIC $0 Supervised by Investigator 0 HLTH CAN $0 MOH $0 Fellows: HSFO/C $0 SSHRC $0 Post-Doc. and Clin. no data Industry $0 Other Sources $78,000



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HOSPITAL: Sunnybrook & Women’s College Health Sciences Centre Sunnnybrook Site


Total Number of Awards: 320 Research Funds 108 Career Awards 22 CIHR $9,094,898 Studentship Grant Awards: NSERC $204,468 NCIC $2,563,283 Supervised by Investigator 62 HLTH CAN $0 MOH $998,942 Fellows: HSFO/C $1,938,987 SSHRC $0 Post-Doc. and Clin. 37 Industry $2,837,692 Other Sources $45,717,983







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HOSPITAL: Sunnybrook & Women’s College Health Sciences Centre Women’s College Site


Total Number of Awards: 35 Research Funds 22 Career Awards 2 CIHR $3,876,751 Studentship Grant Awards: NSERC $0 NCIC $328,408 Supervised by Investigator 3 HLTH CAN $0 MOH $353,794 Fellows: HSFO/C $53,980 SSHRC $35,000 Post-Doc. and Clin. no data Industry $0 Other Sources $2,441,582



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Total Number of Awards: 60 Research Funds 19 Career Awards 1 CIHR $645,470 Studentship Grant Awards: NSERC $36,618 NCIC $0 Supervised by Investigator 14 HLTH CAN $0 MOH $3,000,000 Fellows: HSFO/C $25,881 SSHRC $0 Post-Doc. and Clin. 11 Industry $164,000 Other Sources $10,443,827



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Total Number of Awards: 1357 Research Funds 299 Career Awards 52 CIHR $25,137,703 Studentship Grant Awards: NSERC $763,378 NCIC $10,960,972 Supervised by Investigator 462 HLTH CAN $523,038 MOH $2,543,970 Fellows: HSFO/C $4,483,270 SSHRC $20,000 Post-Doc. and Clin. 368 Industry $11,923,312 Other Sources $61,823,582



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The information on the following pages was provided by each individual intra/extradepartmental unit. Any additional inquiries should be addressed to the specific Unit.


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Engineering • Institute of Medical Sciences • Immunology • Laboratory Medicine & Pathobiology • Medical Biophysics

• Medical Genetics & Microbiology • Medicine • Nutritional Sciences • Obstetrics and Gynaecology • Ophthalmology and Vision Sciences • Pharmacology • Physical Education and Health • Physiology • Psychiatry • Psychology • Public Health Sciences • Surgery

Other Participants : • Canadian Diabetes Association • TriHospital Diabetes Education Centre • Samuel Lunenfeld Research Institute • Hospital for Sick Children Research Institute • Toronto General Research Institute Overall Research Objective : To foster programs of research, education and patient care in diabetes at the University of Toronto and its affiliated hospitals. To develop an endowment to support the activities of the Centre and to establish new research programs in areas related to diabetes in a number of clinical and basic sciences departments of the Faculty. Current Major Areas of Research : • Atherosclerosis • Clinical trials • Complications of diabetes • Diabetic nephropathy • Genetics of diabetes • Glucagon related peptides • Gut hormones • Immunology of diabetes • Insulin secretion • Insulin signaling • Integrative biology • Lipoprotein kinetics • Membrane biology • Molecular biology • Molecular genetics and evolution - Text last updated April 2007


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CENTRE: Joint Centre for Bioethics The University of Toronto Joint Centre for Bioethics is a partnership among the University of Toronto, Baycrest Centre for Geriatric Care, Bloorview Kids Rehab, Centre for Addiction and Mental Health, Centre for Clinical Ethics of Providence Centre (a shared service of Providence Healthcare, St. Joseph’s Health Centre and St. Michael’s Hospital), The Hospital for Sick Children, Humber River Regional Hospital, Mount Sinai Hospital, North York General Hospital, Ontatrio Genomics Institute, Sunnybrook Health Sciences Centre, Toronto Community Care Access Centre, Toronto East General Hospital, Toronto Rehabilitation Institute, Trillium Health Centre and University Health Network (Princess Margaret Hospital, Toronto General Hospital, and Toronto Western Hospital) . The mission of the Joint Centre is to provide leadership in bioethics research, education and clinical activities. Students, Research Assistants and Fellows : The Joint Centre for Bioethics has a formal doctoral-stream Collaborative Program in Bioethics through the School of Graduate Studies. The participating graduate units are: Department of Health Policy, Management and Evaluation, Institute of Medical Science, Faculty of Law, Faculty of Nursing, Department of Philosophy, Department of Public Health Sciences and Department for the Study of Religion. The Joint Centre for Bioethics also has a professional MHSc degree in Bioethics through the Institute of Medical Science. Participating Departments in the Faculty : Almost all the departments in the Faculty participate in the Joint Centre for Bioethics. There is a clinical ethics fellowship and research grants support fellows, graduate students and research associates and assistants in specific projects. Other Participating Faculties and Departments : Arts and Science, Law, Management, and Nursing Overall Research Objective : To foster interdisciplinary research and scholarship, link education to research, and disseminate research findings to improve policies and practices. Current Major Areas of Research : • Canadian Program on Genomics and Global Health • Canadian Priority Setting Research Network • Organizational Ethics Research Group • Project to Examine Effectiveness in Clinical Ethics • Public Health Ethics Interest Group • Rehab and Continuing Care Ethics Research Group • - Text last updated April 2007


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CENTRE: Terrence Donnelly Centre for Cellular and Biomolecular Research It is now clear that continued progress in medicine and health research is dependent upon the integration of technology, expertise, and thought from diverse disciplines. This new theoretical architecture presents a challenge which is best addressed through creation of dedicated interdisciplinary centres. The University of Toronto has addressed this challenge through the establishment of the Donnelly CCBR, a unique centre in which investigators from the Faculty of Medicine, Pharmacy, Applied Sciences & Engineering, and Arts & Science are brought together in an open, think-tank environment. The DCCBR is mandated to stimulate novel interactions at the interface of biology, chemistry, engineering and computer science in order to develop and apply new technologies for approaching the most challenging biological problems in the post-genomic era. Under the direction of Professor Brenda Andrews, the Donnelly CCBR Director, the Centre is overseeing the development of the research programmes by participating in multi-faculty recruitments which will consolidate current strengths and build new ones. Academic Staff : 30 Students & Fellows : Post-Doctoral Fellows 36 Ph.D. Students 89

Research Associates 13

Participating Departments and Units : Faculty of Medicine: • Banting & Best Department of Medical Research • Biochemistry • Medical Genetics & Microbiology • Surgery Institute for Biomaterials & Bioengineering Faculty of Pharmacy

Faculty of Applied Sciences & Engineering • Department of Chemical Engineering & Applied Chemistry • Department of Electrical & Computer Engineering Faculty of Arts & Science • Department of Computer Science • Department of Chemistry

Overall Research Objective: . The fundamental mandate of the DCCBR is to create a research environment that encourages the integration of biology, computer science, mathematics, engineering and chemistry and that spans leading areas of biomedical research. Current Major Areas of Research:

• Integrative Biology (Functional genomics; Proteomics; Bioinformatics; Systems biology; Chemical biology and chemical genomics; Structural biology)

• Bioengineering and Functional Imaging (Regenerative medicine, technological

developments in cell & tissue imaging; high throughput cell biology)

• Models of Disease (Stem cell biology; Model organisms; Animal models of human disease)

- Text last updated April 2007


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CENTRE: Clinical Science Division Academic Staff : 30 Students & Fellows : Graduate Students 53 Post-doctoral & Clinical Research Fellows 21 Participating Departments in the Faculty : • Medicine • Surgery Overall Research Objective : To foster a strong intellectual environment for clinician-scientists and basic scientists to undertake research programs alone, or in collaboration with one of the major research groupings and to provide a superior milieu for the training of research fellows and graduate students. Current Major Areas of Research : • Molecular Medicine Program • Cardiovascular sciences • Group in Membrane Biology • Gastroenterology/Nutrition • Hematology/Oncology • Infectious diseases/HIV • Renal physiology/pathophysiology • Respiratory sciences - Text last updated April 2007


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Other Participating Faculties & Departments : OISE/UT, Library and Information Science, Institute for Medical Science, Standardized Patient Program, Surgical Skills Centre at Mount Sinai Hospital, Centre for Faculty Development at St. Michael’s Hospital, Program in eHealth Innovation, Faculty of Medicine Acadamies; Faculty of Nursing, Faculty of Pharmacy, Departments of Kinesiology, Psychology, Sociology, English and Engineering, Michener Institute. Other Participants : Ontario Medical Education Network, (McMaster University, Queen’s University, University of Ottawa, University of Western Ontario and Northern Ontario Medical School). Addis Ababa University in Ethiopia, Technion Medical School, Haifa, Israel and Imperial College, London, England. Participating Hospitals : All teaching hospitals affiliated with the University of Toronto. Overall Research Objective : To advance healthcare education and practice through research. Current Major Areas of Research : Programs of research which are drawn from: learners and learning environments and their evaluation and improvement, teachers and teaching evaluation and improvement, informatics in health professional education, interprofessional skills including team work communications, factors affecting diagnostic decision making, the psychometrics of performance-based assessment and the sociology of health professional education research, professionalism and healthcare delivery, computer assisted instruction, clinical and technical skills simulation and assessment, communication skills simulation and assessment, curriculum development and evaluation, interdisciplinary projects in cognitive sciences regarding clinical problem solving, critical thinking and memory, patient safety and medical error, the development of and changes in sciences, Health Sciences Faculties collaborative projects related to educational and practice outcomes of health professional education and faculty development. - Text last updated April 2007


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Studies • Department of Sociology • Division of the Environment/Innis

College,


Participating Organizations : • Centre for Addiction & Mental Health • Promotion & Programs Branch, Ontario

Regional Office, Public Health Agency of Canada

• Ontario Prevention Clearinghouse • Ministry of Health Promotion • Toronto Public Health • Centre for Urban Health Initiatives • Centre for International Health

• Canadian Society for International Health

• IUHPE-International Union of Health Promotion and Education

• PAHO-Pan American Health Organization

• WHO-World Health Organization

Overall Research Objective : To develop a program of applied evaluation research in health promotion provincially, nationally and internationally. Current Major Areas of Research : • Youth in primary health care • Youth and health in the Ukraine • Health Literacy • Mental health promotion • Workplace health promotion • Economic Evaluation in health promotion - Text last updated April 2007


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CENTRE: Centre for International Health

The Centre for International Health is committed to improving the 10/90 gap in global health research, where 90% of the world’s health research is focused on 10% of the world’s health burden, by developing and facilitating multidisciplinary global health research and education opportunities with departments in the Faculty of Medicine, the University of Toronto, international universities and organizations. The CIH enables global health research, education and advocacy. Collaborations continue with the Centre for Global Health Research, CISEPO, Office of International Surgery, Sprinkles, Sickkids International, the Global Pediatric Research Program and the International Centre for Disability and Rehabilitation. The CIH has developed into a national and international preeminent centre for scholarship and teaching. It enables and facilitates ideas, research and education to advance the University’s research priority. In 2005-06 the CIH completed its evaluation of the Southern Africa AIDS Trust (SAT) for CIDA; began a five year AUCC/CIDA funded (Tier 2) collaboration with the University of Port Harcourt, Nigeria to research human resources needed to combat HIV/AIDS; continued research on rural health system reform through collaborations with the China National Health Economics Institute and Kunming Medical College; collaborated with Capital Medical University in Beijing to study and implement the teaching of family/general practice medicine and facilitated student initiated primary health care research in Cambodia, at our field station program and in hospitals in the capital city. The CIH began to host four post doctoral students: Dr. Daniel Hollenberg studying integrated medicine in Canada; Dr. Daniel Sahleyesus studying HIV/AIDS orphans and vulnerable children in Ethiopia; Dr. Stephanie Nixon studying HIV/AIDS at the Health Economics Research Division at the University of Kwazulu Natal in Durban, South Africa; Dr. Youde Guo, from Fudan University, Shanghai, studying health policy and organization in Canada. Participating Departments and Units in the Faculty of Medicine (selected): • Family & Community Medicine • Health Policy, Management & Evaluation • Otolaryngology • Pediatrics • Psychiatry • Public Health Sciences • Rehabilitation Sciences • Surgery • Obstetrics and Gynaecology

• Medicine including Infectious Disease & Emergency

• Microbiology • Continuing Education • Joint Centre for Bioethics • Centre for Health Promotion • Centre for Research in Women’s Health


Education and Health • Faculty of Nursing • Faculty of Dentistry • Faculty of Arts and

Science

• Department of Anthropology

• Department of Sociology, • Faculty of Music • Faculty of Architecture • New College • University College

• Faculty of Pharmacy • Faculty of Law • Faculty of Social Work • Faculty of Engineering

Overall Research Objective: Implementing, facilitating and supporting multidisciplinary research focused on issues of relating to health problems affecting the world’s poorest and most vulnerable. Current Major Areas of Research: • Primary Health Care Development – Cambodia • Rural Health System Reform – China • Urban Community Health Development China

• HIV/AIDS –Zambia, Namibia,Tanzania, Nigeria and Kenya; South Africa, Ethiopia and Malawi

With funds from the Medical Alumni Association, the CIH sends students to international sites to carry out research and elective projects. • Total Number of Studentship MAA Research Awards =13 • Total Number of Overseas Electives = 12 • Total Number of Resident Awards=20 • Post-doctoral or Clinical Fellows (involved in research) = 4 For more information, visit the Centre’s website at: http://intlhealth.med.utoronto.ca/ - Text last updated April 2007


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Engineering






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CENTRE: Centre for Research in Neurodegenerative Diseases Academic Staff : 11 Students & Fellows : Post-Doctoral Fellows 15 Ph.D. Students 9 Research Associates 3 Participating Departments in the Faculty: • Laboratory Medicine and Pathobiology • Medical Biophysics • Medicine • Physiology Overall Research Objective : To identify the possible causes and treatments for Alzheimer's Disease, amyotrophic lateral sclerosis, Parkinson’s Disease and other human neurodegenerative diseases. Current Major Areas of Research : • Alpha-synuclein biochemistry • Amyloid neurotoxicity • Vertibrate and invertibrate animal models of Alzheimer’s Disease, Frontotemporal lobar

degenerations, ALS, Parkinson’s Disease • Brain trophic factors and neuron rescue • Cytoskeletal proteins in health and neurodegenerative disease • Gene expression in Alzheimer's Disease • Genetic basis of familial neurodegenerative disease • Genetics of Amyotrophic Lateral Sclerosis (Lou Gehrig’s Disease) • Genetics of Parkinson’s Disease • Genetics of spinocerebellar ataxias • Pharmacokinetics of anti-dementia drugs • Protein structure, protein-protein interactions • Molecular and cell biology of amyloid, α-synuclein, tau, progranulin, TBP43, peripherin • Developmental neurobiology • Axon guidance and sprouting - Text last updated April 2007


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CENTRE: Centre for Sleep Research Academic Staff: 29 Participating Departments in the Faculty : • Medicine • Physiology • Surgery/Otolaryngology

• Pediatrics • Psychiatry

Other Participating Faculties and Departments : • Faculty of Arts & Science • Dentistry

• Dept Psychology • Dept Cell and Systems Biology

The Centre for Sleep Medicine serves as the focus for basic and clinical research on sleep and its disorders relevant to health and disease. Undergraduate, graduate, professional, technical, industrial/government, public and continuing medical educational programmes are offered. Fundamental research is being carried out in laboratories at the Clinical Science Divison and Department of Physiology in the Medical Sciences Building, Departments of Cell and Systems Biology and Psychology, and at the Toronto Western Research Institute. Clinical research on the pathophysiology and treatment of sleep disorders is being carried out in eight university-affiliated hospitals including The Toronto General Hospital, Toronto Rehabilitation Institute, The Toronto Western Hospital, The Hospital for Sick Children, Mount Sinai Hospital, St. Michael’s Hospital, West Park Hospital and Sunnybrook Health Sciences Centre. Sleep laboratories and clinics in these hospitals also provide diagnostic and treatment services for patients with various sleep-related medical disorders. The Centre for Sleep Research will also interact closely with the Centre for Biological Timing and Cognition currently being built. Mission: The mission of the Centre is to understand the fundamental operations of the sleeping-waking brain and its influence on the neurological, respiratory and cardiovascular systems in health and disease; and to devise, and improve treatments for sleep-related disorders. Overall Research Objective: The goals of the Centre are to understand how physiological and pathological alterations in neurological and sleep/wake state are produced and influence organ systems, and behaviour in health and disease; to improve treatments for sleep-related medical and psychiatric disorders and to reduce human performance inefficiencies resulting from shift work, time zone travel and abnormal sleep-wake activity, and to diseminate knowledge on these issues through research and clinical training programs and continuing education. Current Major Areas of Research: • Sleep and motor control • Sleep and breathing • Sleep-related breathing disorders and

sleep apnea • Sleep and the cardiovascular disease • Comparative sleep-wake physiology • Sleep-wake disorders

• Sleep and effects on performance and function

• Sleep and rehabilitation • Impact of hypoxia on brain and

autonomic functions • Neurobiology of sleep

Current Trainees: • 12 Graduate Students • 8 Post-doctoral Fellows - Text last updated April 2007


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CENTRE: Centre for Research In Women’s Health Core Faculty : 22 Members: 77 Graduate and Post-Doctoral Students supervised by Faculty and Members: 161 Graduate Student Scholarships: 4 The Centre for Research in Women’s Health (CRWH) is a partnership between Women’s College Hospital and the University of Torotnto. CRWH works to promote and foster women’s health research across the University of Toronto working with a range of partners – in clinical settings, academia and community agencies. In addition to its core faculty, CRWH has a multidisciplinary membership of researchers based at the following faculties, hospitals and departments: Faculties

• Faculty of Arts and Sciences • Faculty of Dentistry • Faculty of Information Studies • Faculty of Law • Faculty of Medicine • Faculty of Nursing • Faculty of Pharmacy • Faculty of Social Work • Ontario Institute for Studies in

Education TAHSN Hospitals

• Centre for Addictions and Mental Health

• Hospital for Sick Children • Mt Sinai Hospital • St Michael's Hospital • Sunnybrook Health Sciences Centre • Toronto Rehabilitation Institute • University Health Network • Women's College Hospital

Departments of the Faculty of Medicine • Anesthesia • Family and Community Medicine • Health Policy Management and

Evaluation • Laboratory Medicine and

Pathobiology • Medicine • Nutritional Sciences • Obstetrics and Gynaecology • Paediatrics • Physical Therapy • Physiology • Psychiatry • Public Health Sciences • Radiation Oncology • Surgery

Overall Research Objective: The Centre for Research in Women’s Health integrates scientific and humanistic perspectives to conduct and foster research relevant to women’s lives and to promote its application in diverse communities. Current Major Areas of Research: Cancers Common in Women – epidemiological study of the genetic mutations associated with breast and ovarian cancer, as well as prevention and treatment for high-risk women; participatory community-based research, particularly with women from marginalized communities, to understand women’s experiences with breast cancer and to improve care and support Disability and Chronic Conditions – osteoporosis prevention and treatment; care models for post-fracture care; gender disparities in arthritis treatment; clinical management of HIV in women Reproductive Health – international randomized clinical trials about care during pregnancy, labour and delivery; pharmacy provision of emergency contraception, obstetrical anesthesia Violence and Health – medical/legal responses to sexual assault; anti-violence training for health care providers; intimate partner violence in specific ethnocultural communities Women’s Mental Health – mood disorders and the associated biological and social factors; pregnancy and depression; the links between mental health and violence; mental health and chronic disease - Text last updated April 2007


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GROUP: Bone and Mineral Group Academic Staff : 54 Participating Departments in the Faculty: • Laboratory Medicine & Pathobiology • Medicine • Molecular and Medical Genetics • Obstetrics and Gynaecology • Orthopaedic Surgery • Public Health Sciences • Paediatrics Other Participants: • CIHR Group in Matrix Dynamics • Faculty of Dentistry Peridontics- Oral Physiology • Institute of Biomaterials and Biomedical Engineering • Women’s Health Program Overall Research Objective : To develop collaborative research on the basic biology of bone, osteoporosis, and other bone disorders using cellular and molecular biology as well as epidemiology, translational and clinical approaches. Current Major Areas of Research : • Animal models of bone diseases • Cellular and molecular biology of bone structure and function • Clinical trials related to treatment of osteoporosis and other bone diseases • Endocrine physiology of bone • Epidemiology of osteoporosis • Mechanical properties of bone • Molecular genetics of bone diseases • Paediatric bone disease • Fracture treatment and prevention • Determinants of bone fragility Activity : • Osteoporosis grand rounds in collaboration with UHN, MSH and St. Michael’s Hospital • Organize research seminars • Organize annual Research Day – ‘Bone and Mineral Research’ • Sponsor annual scholarships Awards - 1 . Mr.Lai Lick Pui, a Ph.D. student from the University of Toronto, Department of

Pharmacology, under the supervision of Dr. Jane Mitchell, Ph.D., Associate Professor - 2. Mr. Balram Sukhu, Ph.D. Student from the University of Toronto, Faculty of Dentistry,

under the supervision of Dr. H.C. Tenebaum, Professor, Faculty of Dentistry, Both have been awarded the Bone and Mineral Scholarship for the academic year 2006-2007. -There are many graduate students and post-doctoral as well as clinical fellows working with members of the Bone and Mineral Group but not sponsored by us. - Text last updated June 2006


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INSTITUTE: Institute of Medical Science Academic Staff : 529 Participating Departments in the Faculty : The Institute of Medical Science is the graduate unit for all the clinical departments in the Faculty of Medicine (with the exception of Laboratory Medicine & Pathobiology). Its multidisciplinary faculty represents virtually every department in the Faculty of Medicine and includes members from other faculties across the U of T campus. The faculty and students are located on the University campus in the Medical Sciences Building, as well as in the various Hospital Research Institutes that form the University of Toronto Health Sciences Complex. Overall Research Objective : To provide structured education and training of individuals for research careers in traditional biomedical sciences (molecular/cellular and integrative biology) as well as in clinical investigation/health services research and bioethics. This is fulfilled by provision of programmes at the graduate level, and also includes participation in the MD/PhD programme. The emphasis is on the development of research skills backed by broad exposure to medical science and biology that will lead the student to independent scholarship and inquiry. The programmes are directed to both professional and non-professional students, although a special mission of the IMS is the training of clinician scientists. The IMS also participates in the Royal College of Physicians and Surgeons Clinician Investigator Program, and also houses the Masters of Science in Biomedical Communication, and the Masters of Health Science & Bioethics. - Text last updated April 2007


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INSTITUTE: Institute for Work & Health Overall Research Objective : The mission of the Institute for Work & Health is to research and promote new ways to prevent workplace disability, improve treatment, optimal recovery and safe return to work. The Institute is dedicated to research and to the transfer of research results into practice by the healthcare providers, workplace parties and other policy makers. Through the Institute’s association with the University community, and the Institute’s access to workplaces and key sources of data, it has also become an important training ground for graduate students and young investigators. Current Major Areas of Research : • Behavioural consequences of insurance and regulation • Epidemiology of disability • Evidence-based practice • Labour market experiences and health • Measurement of health and function • Prevention of Disability • Statistical methods • Workplace interventions and evaluations - Text last updated April 2007


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PROGRAM: Cardiovascular Collaborative Program Academic Staff : 77 Graduate Students : 36 Participating Departments and Units : • Anesthesia • Dentistry • Exercise Science • Health Policy, Mgmt & Evaluation • Inst. of Biomaterials & Biomed Eng • Inst. of Medical Science • Laboratory Medicine & Pathobiology • Medical Biophysics • Medicine • Nursing • Pharmaceutical Sciences • Pharmacology • Physiology • Public Health Sciences • Rehabilitation Science • Social Work • Surgery Overall Research Objective : To develop cooperative and joint graduate teaching and research across departmental boundaries within the Faculty of Medicine and with the Faculty of Physical Education & Health to enhance the visibility of cardiovascular studies and to facilitate interdisciplinary training and research. Current Major Areas of Research : • Biochemistry of membrane lipids • Cyanotic heart disease • Exercise science • Gender related to cardiovascular studies • Gene expression • Growth factors • Haematology • Heart/lung/kidney • Hypertension/atherosclerosis • Hypertrophy/cardiomyopathy • Infarction/heart failure • Molecular biology • Myocardial protection • Paediatric/fetal development • Periodontal vascularization • Retinal blood flow • Sympathetic nervous system • Transplantation • Vascular haemodynamics and mineralization - Text last updated April 2007


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Sites : Mount Sinai Hospital, St. Michael’s Hospital, University Health Network and Medical Sciences Building, University of Toronto. Overall Research Objective : To build a Centre of the highest clinical and academic quality for patient care, research and education in the field of immunology and transplantation. The program is founded on the belief that multidisciplinary collaboration and effective communication among team members will support continuous quality improvement. Current Major Areas of Research : Research constitutes a major thrust of the Multi Organ Transplant Program with activities in both basic science of immunology/transplantation as well as the clinical outcomes research. A thematic approach to research has now been adopted with basic science programs in the following areas: • Mechanisms of antigen recognition and rejection • Studies of organ preservation injury • Cellular and molecular mechanisms of organ injury • Identification and characterization of new immunosuppressive agents • Mechanism of tolerance induction • Xenotransplantation • Stem cell technology • In vitro organogenesis • Pathogenesis of infectious disease in the immunocompromised host • Gene therapy • Genomics/proteomics As part of the program we have a CIHR funded Training program in Regenerative Medicine www.regenmedcanada.com (course and funding for fellows and students). For applications e-mail: [email protected] - Text last updated April 2007


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INDUSTRIAL FUNDING SOURCES We would like to acknowledge the sponsorship of our industrial partners. Total grants received: Greater than $1,000,000 Aventis Pasteur Ltd. Bayer Inc.

GlaxoSmithKline Inc.

Between $500,000 and $99,999 AMGEN Inc. Apotex Inc. AstraZeneca Canada Inc. Boston Scientific Ltd. Eli Lilly Canada Inc. Genentech Inc. (US) Hoffmann-La Roche Inc. (Canada) Janssen-Ortho Inc. (Canada) Merck & Co., Inc.

Merck Frosst Canada Ltd. Northern Therapeutics Inc. Novartis Pharmaceuticals Canada Inc. Pfizer Canada Inc. Roche Diagnostic GmbH SAIC - Frederick, Inc. Sanofi-Aventis (Canada) The Health Technology Exchange The Toronto Medical Laboratories Partnership

Between $200,000 and $499,999 Abbott Laboratories Ltd. Aegera Therapeutics Inc Allergan Inc. Alteon Baxter Healthcare Corp (Canada) BioMs Technology Corporation Biogen Idec, Inc. Bristol-Myers Squibb Pharmaceutical Group

(Canada) Canada Health Infoway Inc. Charles River Laboratories International, Inc. Elekta Instrument AB Hoffmann-La Roche Ltd. Loblaw Companies Ltd. Neuronetics Inc. Novartis Pharma AG

Novo Nordisk A/S OncoTherapeutics Inc. Ortho Biotech, a Division of Jansenn-Ortho Inc. Pfizer Inc. Roche Products Ltd Sanofi-Synthelabo Inc. Schering Canada Inc. Structural Genomics Consortium TAIHO Pharmaceuticals Co., Ltd. The Multiple Myeloma Research Foundation Transkaryotic Therapies, Inc. Trillium Therapeutics Inc. Unilever Research Vlaardingen Varian Medical Systems, Inc. Wyeth Wyeth-Ayerst Canada Inc.

Between $100,000 and $199,999 ArgiNOx Pharmaceuticals Inc Astellas Pharma Canada, Inc. Bell Canada Boehringer Ingelheim (Canada) Ltd. Bristol-Myers Squibb Foundation Inc. Celgene Corporation Cevena Bioproducts Inc. Clinique La Prairie Research Institute Dompe S.p.A. Eastman Kodak Company Edwards Lifesciences Ellipsis Neurotherapeutics Inc. Guidant Canada Idenix Pharmaceuticals, Inc. Johnson & Johnson Services Inc KNS Canada Inc. Lupus Clinical Trials Consortium, Inc.

Maquet - Dynamed Metabolic Pharmaceutical Ltd Novelis Inc. OrbusNeich Ovation Pharmaceuticals Inc. PARI GmbH Resverlogix Corporation Senesco technologies, Inc. Signal Pharmaceuticals, LLC Smith & Nephew (Canada) Syn X Pharma Transition Therapeutics Inc. Vasogen Inc. Xillix Technologies Corp. Z-Tech (Canada) Inc. Zeneca Pharma Inc


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Less than $100,000 3M Canada ALTANA Pharma Inc. AMGEN Canada Inc. ATF Advances Technologies and Fuels Canada

Inc. Acorda Therapeutics Inc. Actelion Pharmaceuticals Canada Inc. Actelion Pharmaceuticals Ltd Advance Therapeutics Agouron Pharmaceuticals Inc. Alcoholic Beverage Medical Research Foundation Alcon Inc. Alcon Research Ltd Allos Therapeutics, Inc. Almond Board of California Altus Pharmaceuticals Inc. American Cystoscopes Makers Inc. AnorMED Inc. Aprica Childcare Institute Arginox Pharmaceuticals Inc. Argos Therapeutics Inc Array Biopharma AtheroGencis Inc. AtheroMedix Inc. Axcan Pharma Inc. Bausch & Lomb Inc. Beckman Coulter, Inc. Berlex Canada Inc. BioCardia Inc BioMarin Pharmaceutical Inc BioMimetic Pharmaceuticals Inc Biosite Incorporated Biovail Pharma Canada Boehringer Ingelheim Pharmaceuticals Inc. Brystol-Myers Squibb Medical Imaging Burroughs Wellcome Fund CELLutions Biosystems Inc. Cangene Corporation Cardinal Health Cardiome Pharma Group Celera Genomics Group Cell Genesys Inc. Centocor, Inc. Coley Pharmaceutical Group Cook (Canada) Inc. Covance Inc. Delex Therapies Inc. Design Continuum Inc Domantis Ltd Eisai Medical Research Inc. ehn inc. Elan Corporation, plc Elastin Products Company, Inc. Elastin Specialties LTd. Elekta Ltd.

Eli Lilly and Company Estracure Inc ethica Clinical Research Inc Expression Diagnostics Factors R & D Technologies Ltd. Fisher Scientific FoldRx Pharmaceuticals, Inc. GE Healthcare GTx Galross Inc Gemin X Biotechnologies Inc. GeneOhm Sciences, Canada Inc. General Mills, Inc. Genzyme Corporation Gilead Sciences GlaxoSmithKline (Canada) GlaxoSmithKline Inc. H. Lundbeck A/S H.J. Heinz Company of Canada Ltd. Holburn Research Services Inc Hoosier Oncology Group Human Matrix Sciences LLC I D Biomedical Corporation of Quebec ImClone Systems Inc. Immunex Corporation Institut Rosell, Inc. Integrium Corp Interface Biologics Inc. International Medical Innovations Inc. International Olive Oil Council Johnson & Johnson KGK Synergize Inc Kinetic Concepts, Inc. Kraft Canada Inc. LISI Therapeutics Lightsciences Corporation Lumen Therapeutics Lyco Red Natural Products Industries Ltd. MDS Proteomics Inc. Mandarin Restaurant Franchise Corporation MedPharmGene Inc. Medicure, Inc. Medtronic of Canada Ltd Memory Pharmaceuticals Corp. MetRegen MetriGenix Corporation Miikana Therapeutics Miles Canada Incorporated Millenium Biologix Corporation Myogen, Inc. NMT Medical Inc NOVX Systems Inc. NPS Allelix Corporation Nestec Limited New England Research Institutes


86

Less than $100,000 (continued) NociPharm Inc Novadaq Inc. Novartis Institute for Biomedical Research Novartis International AG Novartis Pharmaceuticals Corporation Nura, Inc. Ontario Potato Board Organon Canada Ltd. Ortho-Clinical Diagnostics Otsuka America Pharmaceutical Inc. PAREXEL International PDL BioPharma Peninsula Pharmaceuticals, Inc. Pfizer Inc. Pharmacyclics Inc. Pharmaxis Ltd Picker International Inc. Possis Medical, Inc. Predix Pharma Procter & Gamble Pharmaceuticals Canada, Inc. Purdue Pharma L.P. Q-Med Scandinavia, Inc. QLT Inc. Quintiles Canada, Inc. Replicor Inc Rimon Therapeutics Ltd. Sankyo Pharma Sanofi Winthrop Inc.

Sanofi-Synthelabo Inc. Scion Natural Science Association Serono Canada, Inc. Serono S.A. Sirna Therapuetics Smith and Nephew Richards, Inc Spectranetics Spiration, Inc St. Jude Medical Canada, Inc. St. Jude Medical, Inc. Steba Beheer NV Sulzer-Metco (US) Inc. SuperGen, Inc. Targacept Inc. Teva Neuroscience, Inc. Teva Pharmaceuticals U.S.A. The Medicines Company The Merck Company Foundation ThermoGenesis Corp Tiense Suikerraffinaderii Services N.V. Tillotts Pharma AG Trudell Medical Group Tyco Healthcare Group LP Valeant Pharmaceuticals International Viventia Biotech Wilson Cook Medical Corp ZOEGENE Corporation Zelos Therapeutics Inc

Zimmer of Canada Ltd.


87

OTHER FUNDING SOURCES We would like to acknowledge the sponsorship of our charitable, institutional and government partners.

Total grants received: Greater than $1,000,000 Argonne National Laboratory Arthritis Society Bill & Melinda Gates Foundation Canada Foundation for Innovation Canada Research Chairs Program Canadian Breast Cancer Foundation Canadian Breast Cancer Research Alliance Canadian Cystic Fibrosis Foundation Canadian Diabetes Association Cancer Care Ontario Government of Canada: Canada Research Chairs Government of Ontario: Ministry of Research &

Innovation Government of the United States: National

Institutes of Health (US) Hospital for Sick Children Hospital for Sick Children Foundation Juvenile Diabetes Research Foundation

International McLaughlin Centre for Molecular Medicine Ministry of Research and Innnovation (Ontario) Mount Sinai Hospital

Multiple Sclerosis Society of Canada Networks of Centres of Excellence: Canadian

Network for Vaccines and Immunotherapeutics (CANVAC)

NeuroScience Canada Ontario Innovation trust Ontario Research and Development Challenge

Fund Ontario Genomics Institute Ontario Hospital Association Ontario Institute for Cancer Research Ontario Mental Health Foundation Ontario Problem Gambling Research Centre Physicians' Services Inc. Foundation Private Individuals St. Michael's Hospital The Ontario HIV Treatment Network The Princess Margaret Hospital Foundation University Health Network University of Toronto Various companies Various sponsors

Between $500,000 and $99,999 Anonymous B.r.a.i.n. Child Canadian Institute of Ukrainian Studies Cancer Research Society Inc. Cystic Fibrosis Foundation (US) George Washington University Hamilton Health Sciences Corporation Kidney Foundation of Canada Leukemia & Lymphoma Society McGill University McMaster University National Alliance for Research on Schizophrenia

and Depression

Networks of Centres of Excellence: Automobile of the 21st Century (AUTO 21)

Networks of Centres of Excellence: Canadian Arthritis Network (CAN)

Networks of Centres of Excellence: Canadian Stroke Network (CSN)

Networks of Centres of Excellence: Stem Cell Network (SCN)

Ontario Neurotrauma Foundation Premier’s Research Excellence Award Sunray Diabetes Foundation Universite De Montreal University of Pittsburgh Workplace Safety and Insurance Board

Between $200,000 and $499,999 AllerGen NCE Alzheimer Society of Canada Alzheimer's Association Banting & Best Diabetes Centre Canadian Association of Gastroenterology Canadian Foundation for AIDS Research

(CANFAR) Canadian Health Services Research Foundation Case Western Reserve University Children's Hospital of Denver

Children's Hospital of Pittsburgh Connaught Fund Crohn's & Colitis Foundation of Canada Douglas Hospital Research Centre Eye Institute of Canada Fraser Health Authority Government of British Columbia: Ministry of

Health Government of Canada: Public Works and

Government Services Canada


88

Between $200,000 and $499,999 (Continued) Government of Ontario: Ministry of Energy Government of the United States: National

Institute on Alcohol Abuse and Alcoholism Government of the United States: Office of Army

Research HealthOne Alliance Howard Hughes Medical Institute Inst. for Clinical Eval. Sciences John P. Robarts Research Institute Juvenile Diabetes Research Foundation Canada March of Dimes Birth Defects Foundation (U.S.) Medical College of Wisconsin Mount Sinai Hospital NCE: Allergy, Genes and Environmental Network NCE: PrioNet National Childhood Cancer Foundation National Sanitarium Association Networks of Centres of Excellence: Advanced

Foods and Materials Network (AFMNet) Networks of Centres of Excellence: Canadian

Institute for Photonic Innovation (CIPI) Ontario Thoracic Society Parkinson Foundation of Canada

Rutgers - State University of New Jersey State University of New York/Albany Sunnybrook & Women's College Health Sciences

Centre The Breast Cancer Research Foundation The Change Foundation The Foundation Fighting Blindness - Canada The Michael J. Fox Foundation for Parkinson's

Research The Provincial Centre of Excellence for Child and

Youth Mental Health The Stanley Medical Research Institute The Susan G. Komen Breast Cancer Foundation Toronto Rehabilitation Institute U.S. Dept of Health and Human Services Universite de Shrebrooke University of British Columbia University of Guelph University of Michigan University of Rochester University of Texas at Dallas University of Western Ontario Vanderbilt University

Between $100,000 and $199,999 Amalgamated Transit Union MS American Association for Thoracic Surgery American Association of Neurological Surgeons Barbara Keenan Foundation Bloorview Childrens Hospital Foundation Brigham and Women's Hospital California Strawberry Commission Canadian Blood Services Canadian Institute for Health Information Canadian Lung Association Canadian Patient Safety Institute Canadian Tobacco Control Research Initiative Cancer Care Ontario Cancer Research Institute (US) Centre for Addiction and Mental Health Children's & Women's Health Centre of British

Columbia Christopher Reeve Paralysis Foundation Columbia University New York Dairy Farmers of Canada Foundation Fighting Blindness Genome Prairie Inc. Genomics Ontario Inc Government of Canada: Canadian International

Development Agency Government of Canada: International

Development Research Centre Government of the United States: Centers for

Disease Control and Prevention Le Hopital Sainte-Justine

Massachusetts General Hospital Maternal and Child Health Bureau Ministry of Citizenship and Immigration Motor Neurone Disease Association Muscular Dystrophy Association (US) National Colorectal Cancer Campaign Networks of Centres of Excellence: Mathematics

of Information Technology & Complex Systems (MITACS)

Norfolk General Hospital Ontario Cancer Biomarker Network Ontario Centres of Excellence: Photonics

Research Ontario (PRO) Oxford Health Alliance Prostate Cancer Research Foundation of Canada Retinoblastoma Solutions Rett Syndrome Research Foundation The EJLB Foundation The Hospital for Sick Children Psychiatry

Endowment Fund The James S. McDonnell Foundation The Leukemia & Lymphoma Society of Canada The Rockefeller Foundation The Royal College of Physicians and Surgeons of

Canada The Scottish Rite Charitable Foundation Tourette Syndrome Association (US) University of California, San Franc University of North Carolina (CH) University of Pennsylvania


89

Between $100,000 and $199,999 (continued) University of Waterloo

University of Zurich York University

Less than $100,000 ALS Society of Canada Alberta Heritage Foundation for Medical

Research Alfred P. Sloan Foundation American Academy of Neurology Foundation American Association for the Advancement of

Science American Brain Tumor Association American Digestive Health Found. American Foundation for Suicide Prevention American Health Assistance Foundation American Heart Association American Orthopaedic Foot and Ankle Society Arbeitsgemeinschaft Fur Osteosynthesefragen -

Association for the Study of Internal Fixation Arthritis Foundation Arthritis Research Centre of Canada Assoc.Francaise Contre Les Myopathi Associated Medical Services, Inc. Association for Surgical Education Association of Hemophilia Clinic Directors of

Canada Association of Medical Microbiology and

Infectious Disease Canada Association of Public Health Epidemiologist in

Ontario Banting Research Foundation Baylor College Beatty Benaroya Research Institute at Virginia Mason Biotechnology and Biological Sciences Research

Institute Bloorview MacMillan Children's Ctr Borderline Personallity Disorder Research

Foundation C17 research Network Cambridge Memorial Hospital Canadian Agency for Drugs and Technologies in

Health Canadian Allergy, Asthma and Immunology

Foundation Canadian Anaesthetists' Society Canadian Association of Emergency Physicians Canadian Association of Radiation Oncologists Canadian Centre on Substance Abuse Canadian Food Inspection Agency Canadian Foundation for Dietetic Research Canadian Foundation for Women's Health Canadian Gene Cure Foundation Canadian HIV Trials Network Canadian Heart Research Centre Canadian Hemophilia Society

Canadian Hypertension Society Canadian Institute for Advanced Research Canadian Liver Foundation Canadian Paediatric Society Canadian Psychiatric Research Foundation Canadian Society of Atherosclerosis, Thrombosis

and Vascular Biology Canadian Society of Hospital Pharmacists Canadian Urologic Oncology Group Canadian Urology Research Consortium Cancer Research and Prevention Foundation Canola Council of Canada Carleton University Center for Health Management Research Cervical Spine Research Society Children's Brain Tumor Foundation Children's Hospital Boston Children's Hospital of Eastern Ontario Children's Hospital of The King's Daughters Children's Tumor Foundation Cincinnati Children's Hospital Medical Center City of Toronto Collaborative Research Program: Rehabilitation &

Long-Term Care College of Family Physicians of Canada Cure Autism Now Foundation CureSearch Children's Oncology Group Dalhousie University Dana Foundation Dana-Farber Cancer Institute Dartmouth College Duke University E.A. Baker Foundation of the CNIB Emory University Epilepsy Canada Estate of Betty Irene West European Commission Fonds de la Recherche en Sante du Foundation for Lung Cancer Fowler Kennedy Sport Medicine Clinic Fragile X Research Foundation of Canada France-Canada Research Foundation Friends of St. Michael's Hospital Gage Occupational & Environmental Garrod Association Glaucoma Research Society Glenfield Hospital Government of Canada: Canadian Heritage Government of Canada: Citizenship &

Immigration Canada


90

Less than $100,000 (continued) Government of Canada: Department of National

Defence: Defence Research & Development Canada

Government of Canada: The Public health Agency of Canada

Government of Ontario: Ministry of Agriculture and Rural Affairs

Government of Ontario: Ministry of Community, Family & Children's Services

Government of the United States: Department of Agriculture

Government of the United States: Department of Veterans Affairs

Grey Bruce Health Services Health Innovation Henry White Kinnear Foundation Human Frontier Science Program Organization Huntington's Disease Society of America ICON Institute of Health Economics International Life Sciences Institute International Society for Clinical Densitometry Jeffrey Modell Foundation Jewish Gen Hosp, McGill-CIHR Jewish Vocational Services Toronto Laurentian University Lawson Foundation Lesbian Health Fund Leukemia Research Foundation London Health Sciences Centre Macula Vision Research Foundation Montreal Heart Institute Muscular Dystrophy Association of Canada Networks of Centres of Excellence: Canadian

Language & Literacy Research Network (CLLRNet)

Networks of Centres of Excellence: Protein Engineering Network (PENCE Inc.)

New York University North Americal Pediatric Renal Transplant

Cooperative Study Northern California Institute for Obsessive Compulsive Foundation Ontario Association of Medical Laboratories Ontario Centres of Excellence Ontario Clinical Oncology Group Ontario Lung Association Ontario Lupus Association Ontario Ministry of Children and Ontario Public Health Association Ontario Respiratory Care Society Ontario Tobacco Research Unit Ontario Women's Health Council Oregon Health Sciences University Osteoporosis Society of Canada

Otsuka Mayland Research Institute Ottawa Health Research Institute Paediatric Consultants Pan American Health Organization Parkinson's Disease Foundation Physiotherapy Foundation of Canada Providence Continuing Care Centre Queen's University REMAD Foundation Limited Roswell Park Cancer Institute Royal Society of Canada Ryerson University Saskatchewan Agriculture and Food Savoy Foundation Shwachman-Diamond Syndrome Canada

International Social Housing Services Corporation Society for Academic Continuing Society of Cardiovascular Anaesthesiologists St Joseph Health Centre St. Jude Children's Research Hospital Stanford University Stanley Foundation Surgical Infection Society The Alberta Emerald Foundation For

Environmental Excellence The Anemia Institute for Research and Education The Association of Professors of Obstetrics &

Gynaecology The Canadian Chiropractic Research Foundation The Cleveland Clinic The Dr. Charles H. Best Foundation The Hearing Foundation of Canada The Jarislowsky Foundation The Montreal General Hospital The National Surgical Adjuvant Breast and Bowel

Project (NSABP) The Ontario Council on Gradual Studies The Ottawa Hospital The Pediatric Oncology Group of Ontario The Society for Gynecologic The Tema Conter Memorial Trust The Thoracic Surgery Foundation for Research

and Education The University of Texas The Workers' Compensation Board of British

Columbia Think First Foundation of Canada Thunder Bay Regional Health Science Medical

Center Toronto Academic Health Science Council Toronto Centre for Antimicrobial Research &

Evaluation Toronto Transit Commission University Renal Research and Education

Association


91

Less than $100,000 (continued) University of California - Irvine University of Florida University of Manitoba University of Maryland University of Medicine and Dentistr University of Minnesota University of Ottawa University of P.E.I. University of Tennessee University of Utah

University of Victoria University of Washington Various Sponsors Various Sponsors Washington University St Louis Wellcome Trust Wellesley Central Health Corporation Wellspring West Park Hospital Foundation Yakult Honsha Company Ltd Yale University


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http://www.medresearch.utoronto.ca/

Based on RIS data snapshot : 4 February 2008, 0954hrs

Version 1: March 11, 2008

TABLE OF CONTENTS Message from the Vice Dean, Research and International Relations ......................................IV Acknowledgements .......................................................................................................................XII Terms of Reference.......................................................................................................................XIII Tables and Figures Table 1: Summary of Department Research Funding vs Sponsor in THOUSANDS of Dollars....... 1 Table 2: 5-year Departmental Research Funding in THOUSANDS of Dollars By Campus vs

Affiliated Hospital Location..................................................................................................... 2 Table 3: Department Research Funding vs Location, All Sponsors in THOUSANDS of dollars ..... 3 Table 4: Summary of Location Research vs Sponsor (Funding Source) in THOUSANDS of

Dollars .................................................................................................................................... 4 Table 2A: Research Funding 3-year Averages By Department ....................................................... 5 Table 2B: Research Funding 3-year Averages By Department in CONSTANT Dollars ................. 6 Table 3A: Three-year AVERAGE of Department Research Funding vs Location, All Sponsors

in THOUSANDS of Dollars .................................................................................................... 7 Table 3B: Three-year AVERAGE of Department Research Funding vs Location - Tri-Council

(CIHR / NSERC / SSHRC) only in THOUSANDS of Dollars ................................................ 8 Table 4A: Research Funding 3-year Averages By Location of Research ....................................... 9 Table 4B: Research Funding 3-year Averages By Location of Research in CONSTANT

Dollars ................................................................................................................................. 10 Table 5: Research Funding By Source in THOUSANDS of Dollars, 8-year Distribution Profile .... 11 Figure 1: Comparison of Research Funding by Sponsor Source .................................................. 12 Table 6: Research Funding By Type of Grant ................................................................................. 13 Table 7: Research Personnel by Department ................................................................................. 14 Table 8: Summary of Research Personnel Located at Affiliated Teaching Hospitals .................... 15 Table 9: Research Space at the University of Toronto Campus by Department............................ 16 Table 10: Graduate Student Funding (Awards and Stipends) by Income Source Type................ 17 Table 11: Graduate Student Funding (Awards and Stipends) by Graduate Unit........................... 18 Table 12: Graduate Student Funding (Awards and Stipends) by Administrative Location and

Source .................................................................................................................................. 19

Synopsis of Research Activities of the Faculty of Medicine: 2006-2007

Departmental Synopses Notes to Faculty of Medicine Departments...................................................................................... 20 Summary of Department research funding and personnel ............................................................. 21 Anesthesia........................................................................................................................................ 22 Banting and Best Department of Medical Research ....................................................................... 23 Biochemistry ..................................................................................................................................... 24 Family and Community Medicine..................................................................................................... 25 Health Policy, Management and Evaluation.................................................................................... 26 Immunology...................................................................................................................................... 27 Inst. of Biomaterials & Biomedical Engineering............................................................................... 28 Laboratory Medicine and Pathobiology ........................................................................................... 29 Medical Biophysics........................................................................................................................... 30 Medical Genetics & Microbiology..................................................................................................... 31 Medical Imaging ............................................................................................................................... 32 Medicine ........................................................................................................................................... 33 Nutritional Sciences.......................................................................................................................... 34 Obstetrics and Gynaecology............................................................................................................ 35 Occupational Science & Occupational Therapy. ............................................................................. 36 Ophthalmology and Vision Sciences ............................................................................................... 37 Otolaryngology ................................................................................................................................. 38 Paediatrics........................................................................................................................................ 39 Pharmacology................................................................................................................................... 40 Physical Therapy.............................................................................................................................. 41 Physiology ........................................................................................................................................ 42 Psychiatry ......................................................................................................................................... 43 Public Health Sciences..................................................................................................................... 44 Radiation Oncology.......................................................................................................................... 45 Speech-Language Pathology........................................................................................................... 46 Surgery ............................................................................................................................................. 47 Affiliated Teaching Hospital Synopses Notes to the Affiliated Teaching Hospitals ....................................................................................... 48 Summary of Hospital research funding and personnel ................................................................... 49 Baycrest Centre for Geriatric Care................................................................................................... 50 Bloorview Kid’s Rehab ( formerly The Bloorview MacMillan Children’s Centre) ............................ 51 Centre for Addiction and Mental Health........................................................................................... 52 The Hospital for Sick Children.......................................................................................................... 53 Mount Sinai Hospital ........................................................................................................................ 54 St. Michael’s Hospital ....................................................................................................................... 55


Sunnybrook Health Sciences Centre, Orthopaedic & Arthritic Site................................................. 56 Sunnybrook Health Sciences Centre, Sunnybrook Site.................................................................. 57 Toronto Rehabilitation Institute ........................................................................................................ 58 University Health Network................................................................................................................ 59 Women’s College Hospital ............................................................................................................... 60 Intra/Extradepartmental Centre, Group, Institute, and Program Synopses Notes to Summary of Intra/Extradepartmental Units....................................................................... 61 Banting and Best Diabetes Centre................................................................................................... 62 Joint Centre for Bioethics ................................................................................................................. 63 Terrence Donnelly Centre for Cellular & Biomolecular Research................................................... 64 Clinical Science Division .................................................................................................................. 65 The Wilson Centre for Research in Education ................................................................................ 66 Gage Occupational & Environmental Health Unit ........................................................................... 67 Centre for Health Promotion ............................................................................................................ 68 Centre for International Health ........................................................................................................ 69 R.S. McLaughlin Centre for Molecular Medicine ............................................................................. 70 Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research ........................ 71 Centre for Research in Neurodegenerative Diseases..................................................................... 72 Positron Emission Tomography (PET) Centre ................................................................................ 73 Centre for Sleep Research............................................................................................................... 74 Centre for the Study of Pain............................................................................................................. 75 Bone and Mineral Group .................................................................................................................. 76 Drug Safety Research Group........................................................................................................... 77 Institute of Medical Science ............................................................................................................. 78 Institute for Work & Health ............................................................................................................... 79 Cardiovascular Sciences (Collaborative Program).......................................................................... 80 Multi Organ Transplant Program...................................................................................................... 81 Program in Neuroscience................................................................................................................. 82 Structural Genomics Consortium..................................................................................................... 83 Industrial Funding Sources .............................................................................................................. 84 Other Funding Sources .................................................................................................................... 87


IV


This synopsis highlights research funding and activities for the period 2006/07 by Faculty of Medicine researchers situated on campus and at the research institutes of the following 10 fully affiliated hospitals: Baycrest Centre for Geriatric Care, Bloorview Kids Rehab, The Centre for Addiction and Mental Health, The Hospital for Sick Children, Mount Sinai Hospital, St. Michael's Hospital, Sunnybrook Health Science Centre, Toronto Rehab Institute, University Health Network and Women’s College Hospital.

Highlights of 2006 - 2007

• Increase from 2005/06 in CIHR and total research funding of 16% and 9%, respectively

• New Canada Research Chairs (16 Chairs)

Tier 1

Charles Boone BBDMR/CCBR Lynne Howell Department of Biochemistry Gordon Keller Department of Medical Biophysics Ren-Ke Li Department of Surgery Jack Tu Department of Medicine Tier 2

Leah Cowen Department of Molecular Genetics Guri Giaever Faculty of Pharmacy Anne-Claude Gingras Department of Molecular Genetics Steven Girardin Department of Laboratory Medicine and Pathobiology Anthony Hanley Department of Nutritional Sciences Igor Jurisica Department of Medical Biophysics Andrea Kassner Department of Medical Imaging Evelyn Lambe Departments of Physiology & Obstetrics and

Gynecology Berge Minassian Department of Paediatrics Jennifer Ryan Department of Psychology Elizabeth Tillier Department of Medical Biophysics


V

• Renewed Canada Research Chairs (14 Tier 2 Chairs) Daniel Durocher Department of Molecular Genetics Brian Feldman Department of Paediatrics Timothy Hughes BBDMR Prabhat Jha Department of Public Health Sciences Andrea Jurisicova Department of Obstetrics & Gynaecology Rupert Kaul Department of Medicine Jeremy Mogridge Department of Laboratory Medicine & Pathobiology Michael Ohh Department of Laboratory Medicine & Pathobiology Régis Pomès Department of Biochemistry Shuzo Sugita Department of Physiology Rachel Tyndale Department of Pharmacology and Toxicology Subodh Verma Department of Surgery Lu-Yang Wang Department of Physiology Andrew Wilde Department of Molecular Genetics

• MRI Early Researcher Award (13 awards)

The Early Researcher Award program (ERA) is a $51 million, 5 year program that aims to help promising, recently-appointed Ontario researchers build their research teams of graduate students, post-doctoral fellows and research associates. The ultimate goal of the program is to improve Ontario’s ability to attract and retain the best and brightest research talent in high-priority economic areas.

In 2006, the following were recipients of this award:

Nancy Baxter Department of Surgery Daniel Durocher Department of Molecular Genetics Paul Frankland Department of Physiology Jennifer Gommerman Department of Immunology Anthony Hanley Department of Nutritional Sciences Fang Liu Department of Psychiatry Jonathon Rast Department of Medical Biophysics Aaron Schimmer Department of Medicine Vuk Stambolic Department of Medical Biophysics Lillian Sung Department of Paediatrics Agnes Wong Department of Ophthalmology & Vision Sciences Zhaolei Zhang BBDMR/CCBR Mei Zhen Department of Molecular Genetics



VI

The publication of this the 21st edition of the Synopsis marks the middle of my sixth year as Vice Dean, Research and International Relations. It has been a pleasure to serve in this role and as I begin my second term I look forward to tackling the funding challenges alluded to below as well as facilitating the Faculty submissions for the recently announced CFI competition. I am joined in this endeavor by my colleagues George Fantus, Associate Dean, Research, and Mingyao Liu, Director for International Research Relations. I thank also Patricia Brubaker who served as an exemplary Acting Vice Dean, Research and International Relations during my administrative leave early this year. Finally I wish to acknowledge the excellent contributions of GJ Baylon and Rosalind Waxman who collect and maintain our funding database and produce the reports for this very important document, in only 6 months after the start of data collection!! Creation of the CIHR, as well as establishment of federal funding programs including the Canadian Foundation for Innovation, Canada Research Chairs, and Genome Canada; and at the provincial level, establishment of the Ontario Research Fund and the Early Researcher Awards over the past 8 years have dramatically improved the research climate in Canada and Ontario. The health research community in Toronto has benefited tremendously from infrastructure and salary award funding from these initiatives. The recent “flat-lining” of the CIHR operating budget is a very worrisome development. What we need is balanced and stable funding commitments (operating, infrastructure and career awards) at both provincial and federal levels to fund the full costs of research. We will advocate for this over the coming year.

Peter N. Lewis, Ph.D. Vice Dean, Research and International Relations March 11, 2008


VII

SYNOPSIS OF RESEARCH ACTIVITIES 2006 - 2007 The Synopsis of Research Activities in the Faculty of Medicine is published annually by the Faculty Research Office. This is the 21st edition, which covers the period from April 1, 2006 to March 31, 2007. It presents data and analysis of direct research funding and awards received by faculty members in the Faculty of Medicine for this period. These include operating grants, equipment and maintenance grants, and personnel awards to principal investigators and trainees (graduate students, postdoctoral and clinical fellows), and other research related special grants. Data for the previous four years are presented for comparison. In addition, funding received (as opposed to the total project award) during this period from the Canadian Foundation for Innovation (CFI) and from the Ontario Innovation Trust (OIT) or ORF are reported in a separate category. Overhead received and indirect costs such as building maintenance, library and computing services, administrative services, faculty salaries, and basic equipment cost and maintenance are not included. Funding received is segregated by departments and by geographic locations: on campus or in the affiliated hospitals. Guidelines defining research funding and its assignment are described in the Terms of Reference on page XIII. The Faculty Research Office works closely with all Faculty departments, the affiliated hospitals and hospital research institutes to ensure the data reported are as complete and accurate as possible.

INTRODUCTION The Faculty of Medicine at the University of Toronto is the largest medical faculty in Canada and ranks at the top in North America. Currently it admits 224 students to its first year of a 4-year undergraduate medical program. At the post-graduate level, the Faculty offers 72 specialty training programs leading to certification by the Royal College of Physicians and Surgeons of Canada, or by the College of Family Physicians of Canada. In addition to its primary responsibility in medical education, the Faculty participates heavily in the education of undergraduates in the Faculty of Arts and Science and in other health science faculties. To complete its educational role, members of the Faculty actively supervise a large number of graduate students enrolled in M.Sc. and Ph.D. programs, and organize and teach graduate courses. There are 26 departments in the Faculty including 9 departments in basic science (including the Institute of Biomaterials and Biomedical Engineering), 15 in clinical science (including the departments of Physical Therapy, Occupational Therapy and Speech-Language Pathology) and two in community health. In addition, there are 17 extra-departmental units (EDUs) organized as either a Centre, Division, Institute, Group, Unit, or Program. These units are inter-departmental in their structure and engage in multidisciplinary research and education. The Faculty has more than 5,000 faculty members holding a range of academic positions that are fully or partly salaried on University budget, or are non-salaried. The scope of research activity in the Faculty of Medicine is very broad, ranging from basic science, clinical investigation to community health and the rehabilitation sciences. There is a research continuum from the curiosity-driven to the applied. At one end are studies at the


VIII

molecular and gene level to create fundamental knowledge crucial to our understanding of the normal and the disease biological process, leading to advancements in diagnosis, more effective prevention and treatment of disease. At the other end are research activities on the promotion of health and wellness, the improvement of rehabilitation, the prevention of disability and the development of policy on health and health administration. The Synopsis measures this large research enterprise in terms of its annual research revenues.

RESEARCH FUNDING: 2006 – 2007 Researchers in the Faculty of Medicine receive research funding from national, provincial and foreign funding agencies. These include the Canadian Institutes for Health Research (CIHR), Natural Sciences and Engineering Research Council (NSERC), Social Sciences and Humanities Research Council (SSHRC), Health Canada (HLTH CAN), and the Ontario Ministry of Health (MOH), and disease-oriented agencies such as the National Cancer Institute of Canada (NCIC), the Heart and Stroke Foundation of Ontario/Canada (HSFO/C), the National Institutes of Health, the Howard Hughes Medical Institute of the United States, and the US Department of Defense (Cancer Programs). In 2006/07, the Faculty received a total of $554 million in research funds from all sources (Table 1), an increase of 9% from the previous year of $510 million. This represents a rolling average growth of about 2% annually (Table 2B). Research grants accounted for about $487 million of this total, with personnel awards accounting for the remaining $66 million (Table 6). Only the clinical sector increased over the past three years (Table 2B). CIHR continued to be the single major source of funding accounting for about $144 million of the total, an increase of 16% from $124 million in the previous year. Other major single sources of funding were NCIC ($23 million) and the Ontario Ministry of Health ($14 million), with slight decreases from the previous year. Funding from Health Canada doubled to $7.4 million. Funding from other sources including disease-oriented agencies and specific institutional awards increased by 7% to $302 million. Funding from industry increased by 10% to $42 million. Tables 2 and 3 show the "on campus" and "affiliated teaching hospital" geographical assignment of total research revenue. Assignment to hospital sites was about $456 million, accounting for 78 % of the total. Table 4 presents an analysis of the geographical distribution of grants and awards from the various funding agencies. During this period, investigators located in the affiliated teaching hospitals and on campus received $104 million and $40 million respectively from CIHR. Thus as a group, researchers located on campus maintained their share of about 28% of the total CIHR funding. Funding from sources identified as "Other" to campus-based investigators increased by $19 million to about $70 million, whereas there was an increase of about $1 million to hospital-based researchers to $232 million.


IX

GOVERNMENT RESEARCH INFRASTRUCTURE PROGRAMS Canadian Foundation for Innovation (CFI) began its infrastructure funding programs during 1999. At time of writing, CFI has awarded a total of 57 institutional projects from the Faculty and its affiliated hospitals. These projects were based on the following five research platforms identified by the Faculty in consultation with the departments and hospital research institutes:


About $31 million has been received from CFI and OIT, and from Genome Canada for 2006/ 07, up $7 million from the previous year. This does not include CFI New Opportunities awards, which are included in the total research funding.

COMPARISON TO PREVIOUS YEARS Table 2A shows the annual research funding in current dollars by department from 2002 to 2007. The annual changes are analyzed as an average over a 3-year period. Table 2B shows the same data in 2002 constant dollars. All sectors have continued to grow. Overall, total research funding in current dollars over the 5-year period increased by $196 M, or $150 M in constant dollars since 2002. Figure 1 shows that in the 16-year period beginning 1987, research revenue of the Faculty initially followed a linear rate of growth in spite of a slight hiatus from 1993 to 1995, a period of federal budget constraint on research. Table 5 presents the research funding by source in this and the previous seven years. Funding from Canadian federal sources showed an increase from $82 M in 1999/2000 to nearly $242 M in 2006/07, for 41% of the Faculty total research revenue. Research revenue from provincial sources decreased to about 10% of the total, a significant reduction from 14% in 1999/2000. Funding from not-for-profit organizations accounts for about 20% of the total, which is a net increase of $63 M from seven years ago. Industrial funding increased to 7% of the total research revenue from 6% last year. (Figure 1 and Table 5).

RESEARCH AWARDS The total number of research grants in 2006/07 was 4,030, up 6% from the previous year of 3,786 (Table 6). The number of research personnel awards to principal investigators has increased from 176 to 179. Sixteen Canada Research Chairs were awarded in 2006/07.


X

FACULTY RESOURCES Academic Staff The academic staff in the Faculty of Medicine is a heterogeneous group in terms of their source of salary and the kind of academic appointment they hold. For the purpose of this report, there were 4,745 faculty members holding primary academic appointments in the Faculty (Table 7). These primary appointments range from being fully salaried to Status-Only (e.g., those employed and salaried by hospital research institutes). The profile of these faculty members is as follows, with the previous 2005/06 figures in parenthesis: • 4,745 hold primary appointments; of these 4,420 are in affiliated hospitals • 327 are located on campus; of these 164 are tenured and 47 are tenure-stream • 1,321 (1,268) faculty members held research grants and 269 (253) received career awards The distribution of faculty members by sector, department and geographical location is summarized and presented in Tables 7 and 8.

Research Fellows Postdoctoral fellows and clinical research fellows are major contributors to the research enterprise of the Faculty. Tables 7 and 8 summarize the distribution of postdoctoral fellows and clinical research fellows in the Faculty. The number of postdoctoral and clinical research fellows has increased by 37% from 2005/06 to 1103, a very impressive change.

Graduate Student Funding – data for 2006/07 In 2006/07 the total graduate student funding (awards and stipends) was $38.7M (35.7 M), and of this, $22.7M (20.9 M) were awards, while $15.9 M (14.8 M) were stipends, as shown in Table 10. The award and stipend distribution by the Graduate unit is given in Table 11. The breakdown by administrative site is provided in Table 12. The total funding supports about 2000 graduate students. Numbers in parentheses are 2005/06.


XI

Research Space The total campus research space of the Faculty of Medicine currently is 28,277 sq m (Table 9). On-campus research and research-support space in the Faculty has changed dramatically over the past few years. For more than thirty-five years, the Banting Institute, Best Institute, FitzGerald Building, Medical Sciences Building, McMurrich Building, Tanz Neuroscience Building, Gage Research Institute, together with buildings at 1 Spadina, 256 McCaul Street, and 82 and 88 College Street have housed the Faculty of Medicine. This changed seven years ago with the purchase and subsequent renovation of a 10-storey building (6,700 nasm) at 500 University Avenue. This building now houses the Departments of Physical Therapy, Occupational Science and Occupational Therapy, Speech-Language Pathology, as well as the Offices of the Vice Deans of Continuing Education & Professional Development and Postgraduate Medicine. The construction of the $96M Donnelly Centre for Cellular and Biomolecular Research (CCBR) was completed in 2005. The CCBR (10,000 nasm) has 25 faculty and ultimately will house 35 principal investigators and more than 500 research staff. Additionally extensive renovations were made in 2004/05 to the Banting Institute to house the Structural Genomics Consortium, a $60M joint project with the UK. Finally, four years ago the University purchased the former Board of Education building (155 College Street), which has been extensively renovated and now houses three Faculty departments: Public Health Sciences; Health Policy, Management and Evaluation; and Family and Community Medicine. The McMurrich Building, previously home to PHS and HPME, has been returned to the University for other purposes. In the coming year, in connection with the just announced CFI competition, the MSB will be renovated to provide improved research, teaching and support space.


XII



XIII




appointment.










an RIS ‘by-Location’ Report download (data snapshot) initiated at 0954 hrs of February 4, 2008.





AwardsBASICBBDMR 24,446 8,100 173 907 0 0 237 0 41 14,988 131Biochemistry 14,923 5,008 416 1,240 0 0 270 0 266 7,724 222Biomat & Biomed Eng 2,334 917 42 0 0 398 178 0 20 780 37Immunology 13,747 4,004 103 710 0 0 212 0 1,053 7,666 156Medical Biophysics 69,049 7,224 486 9,040 0 105 630 0 1,448 50,116 550Medical Genetics & Microbiology 64,865 15,041 463 4,246 0 0 137 0 834 44,144 510Nutritional Sciences 6,731 2,564 678 82 0 0 0 40 1,105 2,262 139Pharmacology 7,769 1,398 99 118 0 0 75 0 121 5,958 90Physiology 15,521 6,439 539 0 0 0 927 0 120 7,496 303


SUB-TOTAL 33,516 9,961 161 0 524 5,390 265 312 224 16,680 438CLINICALAnesthesia 3,974 1,399 0 0 0 0 0 0 370 2,205 96Family & Community Medicine 8,724 417 0 0 6,220 91 33 12 740 1,212 79Lab. Medicine & Pathobiology 26,033 7,568 786 1,683 2 550 1,921 0 3,421 10,102 404Medical Imaging 9,631 467 72 0 0 567 46 0 477 8,002 72Medicine 107,835 28,688 273 1,968 502 453 7,017 0 18,745 50,190 1,585Obstetrics & Gynaecology 7,977 5,335 52 0 0 0 65 0 722 1,804 84Occupational Therapy 2,789 342 14 0 0 366 0 117 0 1,950 244Ophthalmology And Vision Sci 5,527 901 0 0 0 1,217 4 0 673 2,732 95Otolaryngology 939 185 23 0 0 0 0 0 369 362 16Paediatrics 41,139 18,860 55 721 157 91 1,042 0 2,101 18,111 520Physical Therapy 2,629 621 26 0 0 288 236 0 0 1,457 254Psychiatry 25,215 8,278 69 104 25 598 147 494 2,819 12,679 388Radiation Oncology 11,843 841 145 732 0 305 0 0 1,885 7,935 103Speech-Language Pathology 1,457 292 30 0 0 0 111 41 0 983 155Surgery 34,342 7,003 282 1,494 0 169 1,741 0 4,629 19,025 497

SUB-TOTAL 290,054 81,197 1,827 6,702 6,906 4,695 12,363 664 36,951 138,749 4,592Other 1 11,576 2,353 0 0 0 3,015 74 0 467 5,667 48


GRAND TOTAL 4 586,364 (x $1000) 7,237

1 Includes global research budget of the Institute for Clinical Evaluative Sciences, Structural Genomics Consortium, SARS Laboratory, UofT Equipment maintenance grants, clinical trial grants at the Sunnybrook Hospital/University of Toronto Clinic, ORDCF grants, Ontario Genomics Institute grants, undergraduate summer studentship awards, graduate studentship awards for independent study and Health Communication Research Laboratory in the Faculty of Medicine and Federal Indirect Cost Programme.2 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Health Sciences Centre, University of Toronto and the University Health Network.





1

Synopsis of R

esearch Activities of the Faculty of M

edicine: 2006-2007

DEPARTMENT Hospital Campus Hospital Campus Hospital Campus Hospital Campus Hospital CampusBASICBBDMR 1,626 9,591 3,142 8,539 2,482 44,760 1,561 21,123 2,845 21,602Biochemistry 5,835 4,493 6,035 3,551 16,274 4,479 9,321 4,904 8,503 6,420Biomat & Biomed Eng 1,337 464 1,664 452 987 1,170 1,663 914 1,227 1,107Immunology 5,363 1,013 5,870 1,141 9,154 1,591 9,929 3,429 11,218 2,529Medical Biophysics 37,811 500 46,157 682 72,793 1,629 64,082 1,121 65,944 3,105Medical Genetics & Microbiology 26,430 8,621 30,314 9,729 37,154 8,555 49,934 7,999 53,848 11,017Nutritional Sciences 961 2,608 2,034 2,520 1,607 3,410 1,634 3,184 1,987 4,744Pharmacology 1,097 2,565 1,268 2,657 1,339 2,717 1,079 4,923 1,665 6,104Physiology 4,275 6,757 4,763 6,452 4,714 6,561 5,567 7,415 6,228 9,294

SUB-TOTAL 84,735 36,612 101,247 35,723 146,504 74,872 144,770 55,012 153,465 65,922COMMUNITY HEALTHHealth Policy, Mgmt & Eval 1,135 6,824 1,368 5,476 1,819 6,660 1,327 6,411 1,741 4,633Public Health Sciences 10,410 7,789 11,265 7,563 13,916 10,098 17,653 7,365 16,495 10,646

SUB-TOTAL 11,545 14,613 12,633 13,039 15,735 16,758 18,980 13,776 18,236 15,279CLINICALAnesthesia 2,834 338 3,481 393 3,561 700 3,343 472 3,450 524Family & Community Medicine 1,463 108 1,781 204 4,010 785 4,722 510 8,033 691Lab. Medicine & Pathobiology 18,246 4,852 20,404 6,675 17,707 7,691 17,483 6,715 19,357 6,675Medical Imaging 3,400 4 3,174 5 7,325 15 9,514 179 9,124 507Medicine 64,308 10,081 71,622 10,798 88,744 16,133 88,088 15,514 86,565 21,270Obstetrics & Gynaecology 5,543 0 5,820 0 7,123 1 8,056 26 7,848 129Occupational Therapy 602 764 432 891 604 813 689 976 1,176 1,613Ophthalmology And Vision Sci 1,964 1,072 3,087 1,106 3,448 1,090 3,593 1,324 3,859 1,668Otolaryngology 471 0 487 0 426 21 445 14 888 51Paediatrics 21,417 14 20,531 33 20,562 201 27,665 190 40,616 523Physical Therapy 982 573 991 618 1,321 767 1,042 1,484 1,318 1,311Psychiatry 16,199 554 20,394 486 23,722 1,437 21,666 1,019 23,264 1,950Radiation Oncology 3,438 5 7,607 5 7,269 28 8,154 75 11,590 254Speech-Language Pathology 60 518 46 706 433 1,066 299 1,351 267 1,189Surgery 15,277 660 23,932 807 24,686 885 37,382 1,560 32,540 1,801

SUB-TOTAL 156,204 19,543 183,789 22,727 210,941 31,633 232,141 31,409 249,895 40,156Other 1 26,139 1,512 21,932 12,556 9,868 1,786 12,063 2,331 6,562 5,014

TOTAL 278,623 72,280 319,601 84,045 383,048 125,049 407,954 102,528 428,158 126,371CFI/OIT 2 27,286 7,900 41,551 18,913 19,187 18,141 18,462 4,900 28,198 2,001Indirect Costs 3 11,805 1,160 12,946 1,278 15 1,621






FY 2002-03 FY 2003-04 FY 2004-05 FY 2005-06 FY 2006-07

545,426464,107386,0911 Includes global research budget of the Institute for Clinical Evaluative Sciences, Structural Genomics Consortium, SARS Laboratory, UofT Equipment maintenance grants, clinical trial grants at the Sunnybrook Hospital/University of Toronto ClinicORDCF grants, Ontario Genomics Institute grants, undergraduate summer studentship awards, graduate studentship awards for independent study and Health Communication Research Laboratory in the Faculty of Medicine.2 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Health Sciences Centre, University of Toronto and the University Health Network

586,365548,068

2

Synopsis of R


edicine: 2006-2007

Department All Locations Campus Baycrest Bloorview CAMH HSC MSH SMH SHSC TRI UHN WCH OtherBASICBBDMR 24,446 21,602 0 0 0 2,486 0 0 0 0 359 0 0Biochemistry 14,923 6,420 0 0 0 8,042 179 0 0 0 275 0 7Biomat & Biomed Eng 2,334 1,107 0 261 0 0 0 0 0 340 626 0 0Immunology 13,747 2,529 0 0 0 4,158 771 0 2,098 0 4,141 50 0Medical Biophysics 69,049 3,105 219 0 0 1,269 2,633 0 22,542 0 39,281 0 0Medical Genetics & Microbiology 64,865 11,017 0 0 0 31,038 19,987 0 0 0 2,823 0 0Nutritional Sciences 6,731 4,744 137 0 0 38 371 1,440 0 0 0 0 0Pharmacology 7,769 6,104 0 0 606 154 0 498 389 0 18 0 0Physiology 15,521 9,294 0 0 0 3,607 0 373 0 0 2,218 0 30

SUB-TOTAL 219,387 65,923 356 261 606 50,793 23,941 2,311 25,028 340 49,740 50 37COMMUNITY HEALTHHealth Policy, Mgmt & Eval 6,375 4,633 0 0 341 392 0 137 628 0 243 0 0Public Health Sciences 27,141 10,646 0 0 5,668 1,773 1,433 2,999 393 0 774 1,751 1,704

SUB-TOTAL 33,516 15,279 0 0 6,009 2,166 1,433 3,136 1,021 0 1,017 1,751 1,704CLINICALAnesthesia 3,974 524 0 0 0 792 239 932 433 0 1,053 0 0Family & Community Medicine 8,724 691 0 0 6,321 7 11 747 246 0 501 0 200Lab. Medicine & Pathobiology 26,033 6,675 0 0 0 4,036 5,797 1,005 2,738 0 5,782 0 0Medical Imaging 9,631 507 0 0 0 694 277 0 7,867 0 285 0 0Medicine 107,835 21,270 2,446 193 109 160 9,901 21,636 12,514 904 37,856 482 364Obstetrics & Gynaecology 7,977 129 0 0 0 58 4,841 155 1,585 0 85 1,124 0Occupational Therapy 2,789 1,613 0 97 0 0 0 553 0 462 64 0 0Ophthalmology And Vision Sci 5,527 1,668 0 0 0 1,143 0 968 0 0 1,748 0 0Otolaryngology 939 51 0 0 0 436 0 18 433 0 0 0 0Paediatrics 41,139 523 0 23 0 29,122 36 27 99 70 10,631 609 0Physical Therapy 2,629 1,311 162 25 0 0 0 0 73 750 288 0 21Psychiatry 25,215 1,950 619 5 15,664 1,616 72 914 771 159 3,163 29 251Radiation Oncology 11,843 254 0 0 0 0 0 0 1,790 0 9,705 95 0Speech-Language Pathology 1,457 1,189 0 81 0 0 0 0 121 46 20 0 0Surgery 34,342 1,801 0 0 0 8,090 2,076 3,872 4,311 4,341 9,813 38 0

SUB-TOTAL 290,053 40,158 3,227 424 22,095 46,156 23,250 30,827 32,981 6,731 80,992 2,376 836Other 11,576 5,014 0 0 141 1,383 0 157 1,839 3,000 42 0 0CFI/OIT 30,198 2,001 0 0 0 3,733 20,908 0 2,326 0 1,231 0 0Indirect Costs 1 1,635 1,621 0 0 0 0 15 0 0 0 0 0 0

GRAND TOTAL 586,365 129,995 3,583 685 28,851 104,231 69,532 36,431 63,196 10,072 133,022 4,177 2,5771 Excludes a total of $17.992, 835 from the Federal Indirect Costs Program awarded to affiliate hospitals.




3

Synopsis of R


edicine: 2006-2007


# of Awards

Baycrest Centre for Geriatric Care 3,583 1,555 46 0 0 0 1,332 0 81 569 28Bloorview Kid's Rehab 685 81 25 0 0 0 0 0 28 550 22Centre for Addiction and Mental Health 28,851 5,251 51 0 5,934 463 76 239 3,079 13,758 243Hospital for Sick Children 100,498 23,374 410 3,520 157 191 2,410 0 4,317 66,120 1,036Mount Sinai Hospital 48,503 15,182 433 4,317 2 42 962 0 5,580 21,984 435St. Michael's Hospital 36,826 7,101 186 43 607 2,538 987 0 8,518 16,847 688SHSC

Sunnybrook site 60,741 12,780 246 3,450 0 2,001 3,036 0 2,375 36,853 383 Orthopaedic & Arthritic site 129 51 0 0 0 0 0 0 0 78 2Toronto Rehabilitation Institute 10,072 813 112 0 0 3,388 178 0 52 5,529 62University Health Network 131,791 35,381 542 8,385 529 1,001 4,073 0 15,181 66,699 1,233Women's College Hospital 4,177 2,139 0 0 0 0 0 35 0 2,004 25Other Hospitals 1 2,115 275 0 76 200 417 0 0 0 1,146 30



GRAND TOTAL 586,364 (x $1000) 7,237

1 Research at non-affilitaed hospitals.2 Research at other locations other than UofT Campus and other hospitals.3 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Health Sciences Centre, University of Toronto and the University Health Network.4 Federal Indirect Costs Program awarded to Faculty of Medicine



4

Synopsis of R


edicine: 2006-2007

DEPARTMENT FY 2002-03 FY 2003-04 FY 2004-05 FY 2005-06 FY 2006-07 2002-2005 2003-2006 2004-2007BASICAnatomy and Cell Biology 1 N/A N/A N/A N/A N/A N/A N/A N/ABBDMR 11,217 11,681 47,242 22,684 24,446 154.3 126.2 -22.1Biochemistry 10,328 9,585 20,754 14,224 14,923 54.7 42.5 -13.3Biomat & Biomed Eng 1,801 2,116 2,157 2,578 2,334 9.7 10.7 5.0Immunology 6,376 7,011 10,745 13,357 13,747 31.6 38.8 13.6Medical Biophysics 38,310 46,839 74,422 65,203 69,049 40.6 23.3 -3.2Medical Genetics & Microbiology 35,051 40,043 45,709 57,933 64,865 14.2 20.4 19.4Nutritional Sciences 3,569 4,554 5,016 4,819 6,731 18.9 3.1 17.9Pharmacology 3,662 3,925 4,056 6,003 7,769 5.3 25.7 38.7Physiology 11,032 11,215 11,275 12,982 15,521 1.1 7.8 17.4

SUB-TOTAL 121,347 136,969 221,374 199,783 219,387 37.2 25.9 0.0COMMUNITY HEALTHHealth Policy, Mgmt & Eval 7,959 6,844 8,478 7,738 6,375 4.9 7.6 -13.2Public Health Sciences 18,199 18,827 24,014 25,018 27,141 15.5 15.9 6.3

SUB-TOTAL 26,159 25,671 32,493 32,756 33,516 12.4 23.5 -6.9CLINICALAnesthesia 3,172 3,874 4,262 3,814 3,974 16.1 -0.2 -3.2Family & Community Medicine 1,571 1,985 4,796 5,232 8,724 84.0 75.3 37.9Lab. Medicine & Pathobiology 23,098 27,078 25,398 24,198 26,033 5.5 -5.5 1.4Medical Imaging 3,403 3,179 7,340 9,694 9,631 62.2 81.5 15.7Medicine 74,389 82,421 104,876 103,601 107,835 19.0 13.0 1.4Obstetrics & Gynaecology 5,543 5,820 7,125 8,083 7,977 13.7 17.9 6.1Occupational Therapy 1,366 1,323 1,418 1,665 2,789 2.0 12.3 42.5Ophthalmology And Vision Sci 3,036 4,193 4,537 4,917 5,527 23.2 8.3 10.4Otolaryngology 471 487 447 459 939 -2.3 -2.7 53.6Paediatrics 21,431 20,563 20,763 27,855 41,139 -1.5 17.6 40.9Physical Therapy 1,555 1,609 2,089 2,527 2,629 16.6 25.4 12.5Psychiatry 16,753 20,880 25,159 22,685 25,215 22.6 5.3 0.7Radiation Oncology 3,443 7,612 7,297 8,229 11,843 58.5 4.3 28.3Speech-Language Pathology 578 752 1,500 1,650 1,457 64.8 54.7 -0.9Surgery 15,938 24,738 25,571 38,942 34,342 29.3 27.8 20.2

SUB-TOTAL 175,747 206,515 242,577 263,550 290,053 17.5 13.1 9.4Other 2 27,652 34,489 11,654 14,394 11,576 -20.7 -21.3 2.0

TOTAL 350,905 403,644 508,098 510,483 554,531 20.5 13.2 4.5CFI/OIT 3 35,186 60,464 37,328 23,361 30,198 16.8 -37.8 -4.1Indirect Costs 4 7,837 1,635

GRAND TOTAL 386,091 464,107 545,426 541,682 586,365 18.9 8.4 3.8

1 Defunct Depertment of Anatomy and Cell Biology in 2001/022 Includes global research budget of the Institute for Clinical Evaluative Sciences, Structural Genomics Consortium, SARS Laboratory, UofT Equipment maintenance grants, clinical trial grants at the Sunnybrook Hospital/University of Toronto Clinic, ORDCF grants, Ontario Genomics Institute grants, undergraduate summer studentship awards, graduate studentship awards for independent study and Health Communication Research Laboratory in the Faculty of Medicine.3 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Health Sciences Centre, University of Toronto and the University Health Network.4 Federal Indirect Costs Program awarded to Faculty of Medicine



5

Synopsis of R


edicine: 2006-2007


DEPARTMENTBASICAnatomy and Cell Biology 1 N/A N/A N/A N/A N/A N/A N/A N/ABBDMR 11,217 11,452 45,425 21,604 22,635 149.4 122.1 -23.8Biochemistry 10,328 9,397 19,955 13,547 13,818 51.7 40.1 -15.1Biomat & Biomed Eng 1,801 2,075 2,074 2,455 2,161 7.6 9.2 3.2Immunology 6,376 6,873 10,331 12,721 12,729 29.1 36.7 11.6Medical Biophysics 38,310 45,921 71,560 62,098 63,934 37.8 21.3 -5.1Medical Genetics & Microbiology 35,051 39,257 43,951 55,174 60,060 12.0 18.7 17.2Nutritional Sciences 3,569 4,465 4,823 4,589 6,233 16.6 1.6 15.5Pharmacology 3,662 3,848 3,900 5,717 7,194 3.2 24.0 36.2Physiology 11,032 10,995 10,841 12,364 14,372 -0.9 6.3 15.1

SUB-TOTAL 121,346 134,283 212,860 190,269 203,136 34.6 24.0 -1.9COMMUNITY HEALTHHealth Policy, Mgmt & Eval 7,959 6,709 8,152 7,369 5,903 2.9 6.0 -14.8Public Health Sciences 18,199 18,458 23,091 23,827 25,130 13.3 14.1 4.3

SUB-TOTAL 26,158 25,167 31,243 31,196 31,033 10.2 20.1 -10.5CLINICALAnesthesia 3,172 3,798 4,098 3,633 3,679 13.8 -1.7 -5.0Family & Community Medicine 1,571 1,946 4,611 4,982 8,078 80.4 72.5 35.1Lab. Medicine & Pathobiology 23,098 26,547 24,421 23,045 24,104 3.5 -6.8 -0.5Medical Imaging 3,403 3,116 7,058 9,232 8,918 59.0 78.6 13.7Medicine 74,389 80,805 100,843 98,668 99,847 16.7 11.3 -0.5Obstetrics & Gynaecology 5,543 5,706 6,851 7,698 7,387 11.5 16.2 4.2Occupational Therapy 1,366 1,297 1,363 1,585 2,582 0.0 10.7 39.6Ophthalmology And Vision Sci 3,036 4,111 4,363 4,683 5,118 20.8 6.7 8.3Otolaryngology 471 477 430 438 869 -4.2 -4.1 50.2Paediatrics 21,431 20,160 19,965 26,528 38,091 -3.4 16.0 38.2Physical Therapy 1,555 1,577 2,008 2,406 2,434 14.4 23.6 10.5Psychiatry 16,753 20,471 24,191 21,605 23,347 20.2 3.7 -1.3Radiation Oncology 3,443 7,463 7,017 7,837 10,966 55.4 2.9 25.8Speech-Language Pathology 578 738 1,442 1,571 1,349 61.6 52.2 -2.6Surgery 15,938 24,253 24,588 37,088 31,798 26.8 26.1 18.3

SUB-TOTAL 175,747 202,465 233,249 250,999 268,567 15.2 11.4 7.3Other 2 27,652 33,812 11,206 13,709 10,719 -22.3 -22.3 0.3


GRAND TOTAL 386,089 455,005 524,450 515,886 542,931 16.6 6.8 1.81 Defunct Depertment of Anatomy and Cell Biology in 2001/022 Includes global research budget of the Institute for Clinical Evaluative Sciences, Structural Genomics Consortium, SARS Laboratory, UofT Equipment maintenance grants, clinical trial grants at the Sunnybrook Hospital/University of Toronto Clinic, ORDCF grants, Ontario Genomics Institute grants, undergraduate summer studentship awards, graduate studentship awards for independent study and Health Communication Research Laboratory in the Faculty of Medicine.3 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Health Sciences Centre, University of Toronto and the University Health Network.4 Federal Indirect Costs Program awarded to Faculty of Medicine





6

Synopsis of R


edicine: 2006-2007

Department All Locations Campus Baycrest Bloorview CAMH HSC MSH SMH SHSC TRI UHN WCH OtherBASICBBDMR 31,457 29,161 0 0 2 1,194 0 0 0 0 1,100 0 0Biochemistry 16,634 5,268 0 0 0 6,924 2,871 0 0 0 1,569 0 2Biomat & Biomed Eng 2,356 1,064 0 403 0 0 117 0 0 164 609 0 0Immunology 12,616 2,516 0 0 0 3,376 690 0 2,466 0 3,551 17 0Medical Biophysics 69,558 1,952 126 0 0 1,386 878 0 27,235 0 37,954 27 0Medical Genetics & Microbiology 56,169 9,190 0 0 3 21,747 23,252 0 14 0 1,963 0 0Nutritional Sciences 5,522 3,779 128 0 0 44 229 1,342 0 0 0 0 0Pharmacology 5,943 4,582 0 0 627 210 0 275 229 0 20 0 0Physiology 13,259 7,757 0 0 0 2,901 17 274 0 0 2,279 0 30SUB-TOTAL 213,514 65,269 254 403 632 37,782 28,054 1,891 29,944 164 49,045 44 32COMMUNITY HEALTHHealth Policy, Mgmt & Eval 7,530 5,901 13 0 217 266 0 64 514 108 393 15 38Public Health Sciences 25,391 9,370 0 5 5,655 1,636 2,095 2,195 530 25 1,144 1,478 1,260SUB-TOTAL 32,921 15,271 13 5 5,872 1,902 2,095 2,259 1,044 133 1,537 1,493 1,298CLINICALAnesthesia 4,016 565 0 0 0 670 180 1,065 270 0 1,211 55 0Family & Community Medicine 6,250 662 0 0 3,283 2 743 626 346 0 406 0 182Lab. Medicine & Pathobiology 25,209 7,027 0 0 0 3,688 5,585 910 2,266 0 5,655 46 34Medical Imaging 8,888 234 0 0 0 374 250 0 7,369 0 636 27 0Medicine 105,415 17,639 2,094 70 78 180 9,818 22,737 12,072 685 37,722 2,154 169Obstetrics & Gynaecology 7,728 52 0 0 0 20 4,555 175 528 0 89 2,309 0Occupational Therapy 1,957 1,134 0 101 0 0 0 346 0 313 21 0 42Ophthalmology And Vision Sci 4,994 1,361 0 0 0 952 0 733 5 0 1,942 0 0Otolaryngology 615 29 0 0 0 334 0 41 211 0 0 0 0Paediatrics 29,919 305 0 80 0 25,151 49 17 306 57 3,544 398 11Physical Therapy 2,415 1,188 87 31 0 1 26 4 151 458 170 280 20Psychiatry 24,353 1,469 747 2 15,138 1,480 151 815 824 135 3,397 69 127Radiation Oncology 9,123 119 0 0 0 0 0 0 1,336 0 6,967 701 0Speech-Language Pathology 1,535 1,202 0 49 0 7 0 0 111 78 8 81 0Surgery 32,952 1,416 0 16 33 6,481 2,875 2,891 3,836 4,646 10,579 179 0SUB-TOTAL 265,369 34,402 2,928 349 18,532 39,340 24,232 30,360 29,631 6,372 72,347 6,299 585Other 12,541 3,044 0 39 47 1,518 1,676 84 2,439 3,006 567 122 0GRAND TOTAL 524,345 117,986 3,195 796 25,083 80,542 56,057 34,594 63,058 9,675 123,496 7,958 1,915




7

Synopsis of R


edicine: 2006-2007

Department All Locations Campus Baycrest Bloorview CAMH HSC MSH SMH SHSC TRI UHN WCH OtherBASICBBDMR 6,972 6,848 0 0 0 124 0 0 0 0 0 0 0Biochemistry 5,810 2,183 0 0 0 3,206 213 0 0 0 206 0 2Biomat & Biomed Eng 952 750 0 124 0 0 0 0 0 54 24 0 0Immunology 4,013 959 0 0 0 594 291 0 1,051 0 1,119 0 0Medical Biophysics 8,227 563 56 0 0 352 41 0 2,080 0 5,109 27 0Medical Genetics & Microbiology 15,580 4,057 0 0 0 4,236 6,969 0 14 0 305 0 0Nutritional Sciences 2,467 1,377 128 0 0 37 229 697 0 0 0 0 0Pharmacology 1,617 1,550 0 0 0 0 0 54 9 0 4 0 0Physiology 6,181 4,000 0 0 0 942 0 79 0 0 1,160 0 0SUB-TOTAL 51,819 22,287 184 124 0 9,491 7,743 830 3,154 54 7,927 27 2COMMUNITY HEALTHHealth Policy, Mgmt & Eval 2,620 1,845 10 0 0 133 0 0 271 0 333 15 13Public Health Sciences 8,301 4,080 0 0 839 546 1,560 157 339 15 126 171 466SUB-TOTAL 10,921 5,925 10 0 839 679 1,560 157 610 15 459 186 479CLINICALAnesthesia 1,333 264 0 0 0 530 0 222 176 0 111 30 0Family & Community Medicine 813 215 0 0 169 0 111 159 159 0 0 0 0Lab. Medicine & Pathobiology 8,127 2,234 0 0 0 1,451 1,178 102 1,223 0 1,938 0 0Medical Imaging 509 67 0 0 0 154 0 0 208 0 79 0 0Medicine 26,175 5,038 1,193 0 20 79 2,646 3,960 3,448 47 9,252 410 80Obstetrics & Gynaecology 5,424 5 0 0 0 0 2,706 0 528 0 0 2,185 0Occupational Therapy 356 206 0 14 0 0 0 58 0 78 0 0 0Ophthalmology And Vision Sci 845 0 0 0 0 160 0 30 0 0 655 0 0Otolaryngology 230 15 0 0 0 149 0 0 66 0 0 0 0Paediatrics 11,023 35 0 0 0 6,893 0 0 169 57 3,533 335 0Physical Therapy 608 261 0 0 0 0 22 0 67 150 108 0 0Psychiatry 8,358 1,030 323 0 4,640 618 83 80 130 45 1,281 69 59Radiation Oncology 822 15 0 0 0 0 0 0 91 0 716 0 0Speech-Language Pathology 384 315 0 0 0 0 0 0 0 69 0 0 0Surgery 7,235 238 0 0 33 1,554 1,183 435 935 168 2,688 0 0SUB-TOTAL 72,242 9,938 1,516 14 4,862 11,588 7,929 5,046 7,200 614 20,361 3,029 139Other hospitals 1,740 466 0 0 47 1,027 31 84 51 0 35 0 0GRAND TOTAL 136,722 38,616 1,710 138 5,748 22,785 17,263 6,117 11,015 683 28,782 3,242 620




8

Synopsis of R


edicine: 2006-2007

HOSPITAL FY 2002-03 FY 2003-04 FY 2004-05 FY 2005-06 FY 2006-07 2002-2005 2003-2006 2004-2007Baycrest Centre for Geriatric Care 3,443 3,050 2,824 3,177 3,583 -9.4 2.5 12.6Bloorview Kid's Rehab 1,568 1,438 656 1,044 685 -31.3 2.4 12.4Centre for Addiction and Mental Health 17,358 19,961 24,140 22,255 28,851 18.0 6.6 10.9Hospital for Sick Children 53,579 59,445 55,171 85,958 100,498 1.9 24.3 36.4Mount Sinai Hospital 45,246 52,206 62,284 56,945 48,503 17.3 5.4 -11.7St. Michael's Hospital 26,633 24,640 34,379 35,077 36,826 16.0 20.8 3.5SHSC Sunnybrook site 37,607 44,675 64,826 63,356 60,741 32.0 21.4 -3.2 Orthopaedic & Arthritic site 257 112 . 78 129 . . .Toronto Rehabilitation Institute 1,244 1,054 4,637 14,316 10,072 162.4 274.4 89.5University Health Network 85,853 106,129 120,475 118,179 131,791 18.6 5.8 4.8Women's College Hospital 3,821 6,830 12,604 7,090 4,177 81.6 20.4 -42.4Other Hospitals 2 408 3,381 1,660 1,242 2,115 339.3 -38.0 22.6

SUB-TOTAL 277,017 322,921 383,655 408,717 427,969 17.7 12.7 5.6Other Locations 3 129 59 102 164 462 9.4 67.3 121.6UofT Campus 72,152 84,045 124,342 101,602 126,100 32.2 14.8 2.9


GRAND TOTAL 6 384,483 467,488 545,426 541,682 586,365 19.1 8.0 3.8

1 Percentage represents the annual changes in funding averaged over each three year period.2 Non-affiliated hospitals and Institute of Work and Health3 Research at locations other than U of T campus or other affiliated/non-affiliated hospitals.4 The CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Health Sciences Centre, University of Toronto and the University Health Network.5 Federal Indirect Costs Program awarded to Faculty of Medicine6 Excludes Federal Indirect Costs Program awarded to affiliate hospitals.




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Synopsis of R


edicine: 2006-2007


HOSPITALBaycrest Centre for Geriatric Care 3,443 2,990 2,715 3,026 3,317 -11.2 1.1 10.5Bloorview Kid's Rehab 1,568 1,410 631 994 634 -32.7 1.2 10.7Centre for Addiction and Mental Health 17,358 19,570 23,211 21,195 26,714 15.7 5.0 8.7Hospital for Sick Children 53,579 58,280 53,049 81,865 93,054 -0.1 22.7 34.0Mount Sinai Hospital 45,246 51,182 59,889 54,233 44,910 15.1 3.8 -13.3St. Michael's Hospital 26,633 24,157 33,056 33,406 34,098 13.8 19.0 1.6SHSC Sunnybrook site 37,607 43,799 62,332 60,339 56,242 29.4 19.6 -5.0 Orthopaedic & Arthritic site 257 109 . 74 119 -57.5 . 60.6Toronto Rehabilitation Institute 1,244 1,033 4,459 13,634 9,326 157.3 268.7 87.1University Health Network 104,048 115,842 112,552 122,029 16.3 4.2 2.8Women's College Hospital 3,821 6,696 12,119 6,752 3,868 78.1 18.3 -43.5Other Hospitals 2 408 3,315 1,596 1,183 1,958 330.7 -38.9 19.8



GRAND TOTAL 384,483 458,322 524,448 515,887 542,931 16.8 6.4 1.8

1 Percentage represents the annual changes in funding averaged over each three year period.2 Non-affiliated hospitals and Institute of Work and Health3 Research at locations other than U of T campus or other affiliated/non-affiliated hospitals.4 The CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Health Sciences Centre, University of Toronto and the University Health Network.






10

Synopsis of R


edicine: 2006-2007

SOURCE FY 1999-00 % FY 2000-01 % FY 2001-02 % FY 2002-03 % FY 2003-04 % FY 2004-05 % FY 2005-06 % FY 2006-07 %FEDERAL GOV.Federal Canada 70,101 28.0 89,970 31.4 109,557 35.8 131,170 37.4 144,361 35.5 186,328 36.7 192,543 37.7 219,249 39.5Federal U.S. 12,202 4.9 14,617 5.1 20,047 6.5 14,727 4.2 19,166 4.7 17,013 3.3 17,448 3.4 22,692 4.1Federal Other 182 0.1 14 0.0 . . 8 0.0 . . 0 0.0 7 0.0 0 0.0Sub-Total 82,485 33.0 104,601 36.5 129,603 42.3 145,906 41.6 163,528 40.2 203,341 40.0 209,997 41.1 241,941 43.6PROVINCIAL GOV.Provincial Canada 37,987 15.2 41,071 14.4 45,277 14.8 41,085 11.7 61,892 15.2 93,380 18.4 77,447 15.2 60,836 11.0Sub-Total 37,987 15.2 41,071 14.4 45,277 14.8 41,085 11.7 61,892 15.2 93,380 18.4 77,447 15.2 60,836 11.0LOCAL SOURCESLocal 7,265 2.9 8,441 2.9 10,617 3.5 15,339 4.4 18,640 4.6 26,695 5.3 32,968 6.5 31,929 5.8Internal Univ/Hosp 7,952 3.2 10,424 3.6 10,738 3.5 12,722 3.6 12,550 3.1 13,836 2.7 12,927 2.5 18,936 3.4Sub-Total 15,216 6.1 18,866 6.5 21,355 7.0 28,061 8.0 31,190 7.7 40,531 8.0 45,894 9.0 50,865 9.2INDUSTRYCanadian Industry 29,515 11.8 31,478 11.0 20,815 6.8 22,077 6.3 19,731 4.8 25,219 5.0 22,070 4.3 25,284 4.6U.S. Industry 9,195 3.7 8,555 3.0 7,612 2.5 13,111 3.7 14,515 3.6 10,297 2.0 12,273 2.4 12,965 2.3Other Foreign Ind. 1,982 0.8 1,927 0.7 1,478 0.5 1,138 0.3 11,138 2.7 2,434 0.5 4,130 0.8 4,402 0.8Sub-Total 40,692 16.3 41,960 14.7 29,905 9.8 36,327 10.3 45,384 11.1 37,950 7.5 38,473 7.5 42,651 7.7NOT-FOR-PROFITCanadian Charity 40,620 16.2 43,820 15.3 46,403 15.2 60,666 17.3 65,461 16.1 73,970 14.6 74,207 14.5 84,244 15.2Provincial Charity 10,571 4.2 12,533 4.4 12,665 4.1 15,875 4.5 14,746 3.6 16,792 3.3 17,602 3.4 25,476 4.6U.S. Charity 7,022 2.8 6,145 2.1 7,490 2.4 7,066 2.0 8,449 2.1 8,949 1.8 10,609 2.1 13,602 2.5Other Foreign Charity 1,252 0.5 1,779 0.6 1,925 0.6 1,550 0.4 1,675 0.4 432 0.1 384 0.1 307 0.1Sub-Total 59,464 23.7 64,277 22.4 68,482 22.3 85,157 24.2 90,330 22.2 100,142 19.8 102,801 20.1 123,630 22.4OTHEROther Canadian Inst. 2,402 1.0 2,905 1.0 2,333 0.8 1,935 0.6 1,899 0.5 5,057 1.0 6,627 1.3 6,506 1.2U.S. Institutions 2,069 0.8 2,161 0.8 1,840 0.6 2,337 0.7 1,789 0.4 8,018 1.6 6,717 1.3 6,027 1.1Other Foreign Inst. 153 0.1 79 0.0 231 0.1 327 0.1 248 0.1 205 0.0 384 0.1 135 0.0Sub-Total 4,624 1.9 5,146 1.8 4,404 1.5 4,600 1.4 3,936 1.0 13,281 2.6 13,728 2.7 12,668 2.3MISCELLANEOUSVarious Sponsors 9,791 3.9 10,283 3.6 7,181 2.3 9,769 2.8 10,764 2.6 19,473 3.8 22,142 4.3 20,462 3.7Sub-Total 9,791 3.9 10,283 3.6 7,181 2.3 9,769 2.8 10,764 2.6 19,473 3.8 22,142 4.3 20,462 3.7TOTAL 250,259 100 286,203 100 306,208 100 350,905 100 407,024 100 508,098 100 510,483 100 553,053 100CFI/OIT1 35,186 60,464 37,328 23,361 30,198Indirect Costs 2 7,837 1,635GRAND TOTAL 3 250,259 100 286,203 100 306,208 100 386,091 100 467,488 100 545,426 100 541,682 100 584,887 100Fiscal Year values represent THOUSANDS of dollars.1 The CFI and OIT funding represents infrastructure grants from Federal and Provincial sources.

3 2003-04 value excludes $11,804,786; 2004-05 value excludes $12,946,032; 2005-06 value excludes $15,081,736; 2006-07 excludes $17,922,835 from the Federal Indirect Costs Program awarded to affiliate hospitals.




11

Synopsis of R


edicine: 2006-2007



0%

20%

40%

60%

80%

100%19

87

1988

1989

1990

1991

1992

1993

1994

1995

1996

1997

1998

1999

2000

2001

2002

2003

2004

2005

2006

2007


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ortio

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al F

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0

100

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300

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500

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Tota

l Fun

ding

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ions

)


Other Sources

CIHR Contribution


12

Synopsis of R


edicine: 2006-2007


Research GrantsOperating Grants $449,992,361 3870Collaborative Grants $14,393,505 39Individual Group Grants $2,946,083 20Major Equipment $9,649,049 43Maintenance $268,570 6Conference Grants $278,347 13Travel Grants $324,603 9Techonology Transfer $591,750 4CRC Infrastructure Fund $9,244,401 26

Sub-Total $487,688,669 4030Personnel AwardsScientist, Career Investigator Awards $3,901,131 53CRC Scientists/Scholar Awards $17,050,192 126Scholarship Awards $5,976,973 128Fellowship Awards $12,371,461 331Studentship Awards 1 $27,542,899 2548



GRAND TOTAL 4 $586,365,235 72371 Studentships (both graduate and undergraduate) include direct awards from external sponsoring agencies and internal awards such as: U of T Open Fellowship, Ontario Graduate Scholarship/Fellowships, U of T Life Science Studentships, U of T Tuition Waivers, and U of T Graduate Bursaries.






13



StreamCareer Awards


Cross Appt with Res

Funds


Pri Appt


BASICBBDMR 22 21 1 21 10 3 5 21 4 44 30Biochemistry 33 19 14 21 18 1 16 30 15 92 49Biomat & Biomed Eng 10 7 3 73 3 5 1 12 48 3 8Immunology 28 6 24 34 5 2 5 24 16 58 47Medical Biophysics 72 0 72 70 6 0 16 56 70 319 171Medical Genetics & Microbiology 72 27 45 31 20 6 28 60 20 226 181Nutritional Sciences 24 15 9 14 6 3 3 19 unk 65 5Pharmacology 30 15 15 29 5 2 4 17 unk 40 6Physiology 45 29 16 63 16 4 16 37 unk 163 103SUB-TOTAL 336 139 199 356 89 26 94 276 173 1,010 600COMMUNITY HEALTHHealth Policy, Mgmt & Eval 22 22 0 125 10 4 3 20 75 73 4Public Health Sciences 262 51 211 147 20 4 12 73 unk 138 20SUB-TOTAL 284 73 211 272 30 8 15 93 75 211 24CLINICALAnesthesia 248 2 246 5 2 0 5 27 2 23 10Family & Community Medicine 766 0 766 49 1 0 2 15 13 47 4Lab. Medicine & Pathobiology 211 19 192 70 8 7 15 84 59 124 86Medical Imaging 159 2 157 19 1 0 2 20 n/a 27 11Medicine 903 33 870 74 5 0 73 306 n/a 386 186Obstetrics & Gynaecology 144 1 143 43 2 0 2 25 16 19 18Occupational Therapy 25 25 unk 1 5 3 1 16 n/a 195 2Ophthalmology And Vision Sci 89 2 87 12 1 0 3 17 3 32 15Otolaryngology 74 0 74 24 2 0 0 6 3 5 1Paediatrics 346 0 346 29 1 0 14 127 0 128 71Physical Therapy 21 14 7 11 7 0 3 14 n/a 225 8Psychiatry 686 0 686 46 2 0 19 126 n/a 94 72Radiation Oncology 117 0 117 6 0 0 3 30 3 30 16Speech-Language Pathology 10 10 0 6 5 3 2 12 3 133 2Surgery 326 7 319 58 3 0 16 127 unk 126 107SUB-TOTAL 4,125 115 4,010 453 45 13 160 952 102 1,594 609TOTAL 4,745 327 4,420 1,081 164 47 269 1,321 350 2,815 1,233Based on data received from each individual Department



14

Synopsis of R


edicine: 2006-2007




Prim Appt


FellowsBaycrest Centre for Geriatric Care 12 2 1 9Bloorview Kid's Rehab 10 2 2 1Centre for Addiction and Mental Health 87 16 36 47Hospital for Sick Children 266 46 123 265Mount Sinai Hospital 100 19 49 152St. Michael's Hospital 164 28 79 27SHSC 89 Sunnybrook site 133 28 59 no breakdown Orthopaedic & Arthritic site 1 0 1 no breakdownToronto Rehabilitation Institute 23 0 10 28University Health Network 307 52 258 485Women's College Hospital 13 2 2 no dataTOTAL 1103 193 618 1103Hospital Post-doc numbers based on data provided by each individual hospital




15

Synopsis of R


edicine: 2006-2007

DEPARTMENT Nasm1

BASICAnatomy & Cell Biology n/aBanting and Best Department of Medical Research 2716Biochemistry 1875Institute of Biomaterials & Biomedical Engineering 2 433Immunology 789Medical Biophysics n/aMedical Genetics & Microbiology 2196Nutritional Sciences 1002Pharmacology 1630Physiology 1961


Sub-Total 1,789CLINICALAnesthesia n/aFamily & Community Medicine n/aLab. Medicine & Pathobiology 1447Medical Imaging n/aMedicine 170Obstetrics & Gynaecology n/aOccupational Therapy 626Ophthalmology And Vision Science 563Otolaryngology n/aPaediatrics n/aPhysical Therapy 919Psychiatry n/aRadiation Oncology n/aSpeech-Language Pathology 567Surgery (includes Anatomy Div.) 272

Sub-Total 4,564OTHERBiomedical Communications 69Centre for Research in Neurodegeneratice Disease 1248Clinical Sciences Division Common Lab Space 3108Comparative Medicine 2271Common Research Space 2103Electron Microscopy Unit 74Heart & Stroke / Richard Lewar Centre for Excellence… 321Rehabilitation Sciences Sector 130Structural Genomics Consortium 1203


Based on a data extracted on: July 2006 and May 20071 Nasm - Net assignable square meters2 Includes ONLY IBBME research space at the MSBDoes not include CCBR research space.

Table 9



16





External - Other $708,711.17 $3,463,326.96 $4,172,038.13


Internal - U of T $12,931,102.74 $2,647,798.66 $15,578,901.40

Grand Total $22,747,286.74 $15,919,438.39 $38,666,725.13

1 From data provided by the Office of the Vice Dean, Graduate Affairs

Type of Funding




17

Synopsis of R


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Graduate Unit AWARD STIPEND Grand TotalBiochemistry $1,138,431.94 $1,442,763.46 $2,581,195.40Graduate Department of Rehabilitation Science $667,476.63 $160,666.47 $828,143.10Health Policy, Management & Evaluation $1,299,078.16 $1,096,140.47 $2,395,218.63Immunology $662,342.13 $812,103.35 $1,474,445.48Institute of Biomaterials & Biomedical Engin. $1,107,137.66 $752,330.64 $1,859,468.30Institute of Medical Science $5,995,198.80 $3,266,954.17 $9,262,152.97Laboratory Medicine & Pathobiology $1,239,655.22 $1,248,952.52 $2,488,607.74Medical Biophysics $2,501,034.81 $711,800.32 $3,212,835.13Molecular & Medical Genetics $2,010,477.73 $2,664,974.51 $4,675,452.24Nutritional Sciences $789,170.50 $410,865.38 $1,200,035.88Occupational Health $332,959.68 $10,233.33 $343,193.01Pharmacology $714,171.95 $799,203.30 $1,513,375.25Physical Therapy $481,165.19 $0.00 $481,165.19Physiology $1,357,556.47 $2,109,138.27 $3,466,694.74Public Health Sciences $1,886,300.93 $355,790.42 $2,242,091.35Speech-Language Pathology $565,128.94 $77,521.78 $642,650.72

Grand Total $22,747,286.74 $15,919,438.39 $38,666,725.131 From data provided by the Office of the Vice Dean, Graduate Affairs

Type of Funding




18

Synopsis of R


edicine: 2006-2007

Awards Stipend1

Baycrest/Rotman Institute $103,908.00 $61,000.00 $164,908.00Bloorview Kid's Rehab $2,500.00 $12,700.00 $15,200.00Centre for Addiction and Mental Health $285,959.60 $201,800.00 $487,759.60Hospital For Sick Children $1,521,125.00 $1,921,279.48 $3,442,404.48Mount Sinai Hospital $394,884.00 $761,116.69 $1,156,000.69St. Michael's Hospital $134,000.00 $290,128.82 $424,128.82Sunnybrook Health Sciences Centre and Women's College Hospital $377,150.00 $697,633.33 $1,074,783.33Toronto Rehabilitation Institute $40,000.00 $8,250.00 $48,250.00University Health Network $1,596,418.60 $1,448,719.68 $3,045,138.28

$0.00 $0.00 $0.00Other $144,300.00 $278,100.00 $422,400.00

Off Campus Total $4,600,245.20 $5,680,728.00 $10,280,973.20




OSOTF Total2 $1,902,755.28 Grand Total $38,666,725.13Notes:1 Stipend from Supervisor's Research Grant (sources Internal or External to the Institution)2 Matched Funding (1/3 Donation from Hospital Foundation; 1/3 Ontario Government; 1/3 University of Toronto 3 From data provided by the Office of the Vice Dean, Graduate Affairs







19

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edicine: 2006-2007



20



Total Number of Awards: 7230 Canadian Institutes of Health Research (CIHR) $133,677,699 Natural Sciences and Engineering Research Council (NSERC) $4,985,462 National Cancer Institute of Canada (NCIC) $23,044,405 Health Canada (HLTH CAN) $7,428,895 Ontario Ministry of Health (MOH) $13,604,789 Heart and Stroke Foundation of Ontario/Canada (HSFO/C) $15,368,311 Social Sciences & Humanities Research Council (SSHRC) $1,014,428 Industry Sources $42,650,576 Other Sources $301,300,985 Total Number of Academic Staff: Primary Appointments 4745 On Campus 327 Off Campus 4420 Cross Appointments 1081 Tenured 164 Tenure-stream 47 Career Awards 269 Primary Appointments with Research Awards 1321 Fellows: Post-Doctoral and Clinical Research Fellows 1233 Based on data received from individual Departments


21




Total Number of Awards: 96 Primary Appointments 248 On Campus 2 Off Campus 246 Cross Appointments 5 CIHR $1,398,647 Tenured 2 NSERC $0 Tenure-stream 0 NCIC $0 Career Awards 5 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 27 HSFO/C $0 Cross Appointments 2 SSHRC $0 Studentship Awards: Industry $370,223 Supervised by Primary Appt 23 Other Sources $2,204,643 Fellows: Post-Doc. and Clin. 10

Overall Research Objective : To develop the environment and recruit personnel for research of the highest quality necessary for the advancement of knowledge in the areas of interest to Anesthesia. Current Major Areas of Research ::Faculty in the Department of Anesthesia have developed research interests and programs in a number of fields related to pain management and peri-operative care. These include the following major areas, each represented by an identified contact person. Acute Pain C. McCartney 603-5118 [email protected] Ambulatory Anesthesia F. Chung 603-5118 [email protected] Anesthesia mechanisms B. Orser 480-4864 [email protected] Blood Conservation K. Karkouti 340-5164 [email protected] Cardiovascular D. Mazer 864-5825 [email protected] Critical Care B. Kavanagh 813-8019 [email protected] Malignant Hyperthermia J. Loke 340-3128 [email protected] Neuroscience B. Orser 480-4864 [email protected] Obstetrical Management S. Halpern 323-6008 [email protected] Outcomes Research S. Beattie 340-5164 [email protected] Paediatrics M. Crawford 813-7445 [email protected] Pain mechanisms D. Joo 813-7445 [email protected] Regional Anesthesia V. Chan 340-3227 [email protected] Simulation P.Morgan 323,6269 [email protected] V. Naik 864-5071 [email protected] - Text last updated March 2007

22





Overall Research Objective : To use proteomics, functional genomics and bioinformatics to achieve a comprehensive view of gene function, cell regulatory pathways and gene/protein networks. To understand the molecular basis of biological disorders. Current Major Areas of Research : • Cell cycle • Control of gene expression • Developmental biology • Functional genomics • Mechanism of action of hormones • Membrane structure and function • Muscle biology • Proteomics • Structural biology - Text last updated March 2007

23





Overall Research Objective : To advance and disseminate our understanding of the molecular fundamentals of life through first rate research and academic programs. Current Major Areas of Research : • Biomolecular structure and function • Gene expression and development • Membranes and transport • Molecular cell biology • Molecular medicine • Protein folding • Proteomics and Bioinformatics • Signal transduction and regulation - Text last updated March 2007

24




Total Number of Awards: 79 Primary Appointments 766 On Campus 0 Off Campus 766 Cross Appointments 49 CIHR $416,692 Tenured 1 NSERC $0 Tenure-stream 0 NCIC $0 Career Awards 2 HLTH CAN $6,219,746 With Research Funds MOH $91,125 Primary Appointments 15 HSFO/C $33,289 Cross Appointments 13 SSHRC $11,666 Studentship Awards: Industry $740,000 Supervised by Primary Appt 47 Other Sources $1,211,588 Fellows: Post-Doc. and Clin. 4


genetics, care of the elderly, prescribing and care of people with chronic disabling conditions • Improving population access to primary care - Text last updated March 2007

25




Total Number of Awards: 122 Primary Appointments 22 On Campus 22 Off Campus 0 Cross Appointments 125 CIHR $2,359,378 Tenured 10 NSERC $0 Tenure-stream 4 NCIC $0 Career Awards 3 HLTH CAN $134,138 With Research Funds MOH $1,249,028 Primary Appointments 20 HSFO/C $0 Cross Appointments 75 SSHRC $35,596 Studentship Awards: Industry $0 Supervised by Primary Appt 73 Other Sources $2,596,673 Fellows: Post-Doc. and Clin. 4

Overall Research Objective : To contribute to knowledge, thereby advancing the discipline, improving teaching and improving the theory and practice of health services management and administration and clinical epidemiology. To educate researchers through the M.Sc./Ph.D. program and to foster an appreciation of the methods and application of health services research among graduate students. Current Major Areas of Research : • Clinical evaluative sciences • Financing of health services • Health measurement • Health care improvement • Health performance assessment • Health policy and economics • Organizational research • Outcomes research • Program planning and evaluation - Text last updated March 2007

26




Total Number of Awards: 156 Primary Appointments 28 On Campus 6 Off Campus 24 Cross Appointments 34 CIHR $4,003,515 Tenured 5 NSERC $102,600 Tenure-stream 2 NCIC $709,832 Career Awards 5 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 24 HSFO/C $212,349 Cross Appointments 16 SSHRC $0 Studentship Awards: Industry $1,053,353 Supervised by Primary Appt 58 Other Sources $7,665,793 Fellows: Post-Doc. and Clin. 47

Overall Research Objective : To achieve a fundamental understanding of molecular and cellular aspects of the immune system towards elucidating mechanisms underlying host-pathogen interactions and disease resistance. Current Major Areas of Research : • Antigen presentation • B-cell/T-cell ontogeny • Biochemistry of antigen receptor and cytokine receptor signalling • Cell adhesion molecules • Gene expression • Gene rearrangement in antigen receptor structures • Generation of diversity • Hybridoma technology • Immune disorder & autoimmunity • Immunity to infectious disease • Immunodeficiencies • Lymphokine synthesis and action • Protein structure/function relationships • Repertoire development • Tolerance: self/non-self discrimination • Transgenic and knockout technology • Tumour immunology • Vaccine development - Text last updated December 2007

27




Fac of Med primary appointments $2,334,075 Primary Appointments 10 On Campus 7 Total Number of Awards: 37 Off Campus 3 Cross Appointments 73 CIHR $916,998 Tenured 3 NSERC $41,915 Tenure-stream 5 NCIC $0 Career Awards 1 HLTH CAN $0 With Research Funds MOH $397,900 Primary Appointments 12 HSFO/C $177,681 Cross Appointments 48 SSHRC $0 Studentship Awards: Industry $20,000 Supervised by Primary Appt 3 Other Sources $779,581 Fellows: Post-Doc. and Clin. 8






Departmental Web-site is http://www.utoronto.ca/IBBME - Text last updated March 2007


28




Total Number of Awards: 404 Primary Appointments 211 On Campus 19 Off Campus 192 Cross Appointments 70 CIHR $7,568,358 Tenured 8 NSERC $785,687 Tenure-stream 7 NCIC $1,683,090 Career Awards 15 HLTH CAN $1,870 With Research Funds MOH $550,000 Primary Appointments 84 HSFO/C $1,920,697 Cross Appointments 59 SSHRC $0 Studentship Awards: Industry $3,421,165 Supervised by Primary Appt 124 Other Sources $10,101,775 Fellows: Post-Doc. and Clin. 86




atherosclerosis, ischemic heart disease, lipid disorders, and valvular disease - Text last updated March 2007

29




Total Number of Awards: 550 Primary Appointments 72 On Campus 0 Off Campus 72 Cross Appointments 70 CIHR $7,223,795 Tenured 6 NSERC $486,009 Tenure-stream 0 NCIC $9,040,129 Career Awards 16 HLTH CAN $0 With Research Funds MOH $105,000 Primary Appointments 56 HSFO/C $630,167 Cross Appointments 70 SSHRC $0 Studentship Awards: Industry $1,448,003 Supervised by Primary Appt 319 Other Sources $50,116,109 Fellows: Post-Doc. and Clin. 171


- Text last updated March 2007

30





Overall Research Objective : The mission of the Department of Medical Genetics & Microbiology/Graduate Department of Molecular & Medical Genetics is to conduct world-class research and to train outstanding students in several cutting-edge research areas. Molecular biological, molecular genetic, cellular and systems biological approaches are applied tto studies in six research areas: 1) functional genomics and proteomics; 2) molecular biology and macromolecular structure; 3) molecular medicine and human genetics; 4) model organism genetics and genetic control of development; 5) cell biology and signal transduction; 6) systems biology, computational biology and bioinformatics; and 7) molecular microbiology, virology and infectious disease research. Our aims are to: 1. Establish and/or maintain internationally competitive research programs in the areas listed above; 2. train future generations of independent scientists. Current Major Areas of Research : Signal transduction and cell regulation - Cell cycle and growth control - Transcriptional and post-transcriptional regulation of gene expression - Epigenetics and chromatin regulation - Chromosome dynamics and biology - Functional genomics - Nucleic acid metabolism and function - Structural biology using X-ray crystallography and NMR spectroscopy - Proteomics - Systems biological and bioinformatic analysis of gene regulatory networks, protein interaction networks, cell cycle and development - Analyses of complex genetic disease and single gene disorders - Disease gene mapping and identification - Genome annotation - Cell biology and developmental biology of disease states - Human chromosome structure, function and dynamics - Molecular diagnostics and gene therapy - Yeast, worm, fly, zebrafish, frog and mouse models of development - Stem cell research and haematopoiesis - Neurogenesis and neurobiology - Host-pathogen (viral, bacterial, fungal) interaction - Viral and plasmid segregation - Viral RNA transport and processing Departmental Website: http://www.utoronto.ca/medicalgenetics/ - Text last updated February 2007

31




Total Number of Awards: 72 Primary Appointments 159 On Campus 2 Off Campus 157 Cross Appointments 19 CIHR $466,670 Tenured 1 NSERC $72,200 Tenure-stream 0 NCIC $0 Career Awards 2 HLTH CAN $0 With Research Funds MOH $567,495 Primary Appointments 20 HSFO/C $46,000 Cross Appointments n/a SSHRC $0 Studentship Awards: Industry $476,645 Supervised by Primary Appt 27 Other Sources $8,002,116 Fellows: Post-Doc. and Clin. 11

Overall Research Objective : Characterization of the structure and function of normal and diseased tissue using all modern imaging methods. Physiologically specific imaging at the metabolic, cellular, vascular and tissue level, using MRS, PET, MRI and MEG. Current Major Areas of Research : • Clinical trials of new contrast agents and drugs • Design of new imaging techniques and imaging systems • Integration of imaging data • Magnetic resonance imaging and spectroscopy • MEG and MSI • Minimally invasive diagnosis and therapy • Molecular imaging • Percutaneous and transvascular treatment methods • PET/CT • Picture archival and communications systems (PACS) • Real-time imaging • Tissue characterization by imaging - Text last updated March 2007

32




Total Number of Awards: 1585 Primary Appointments 903 On Campus 33 Off Campus 870 Cross Appointments 74 CIHR $28,687,553 Tenured 5 NSERC $273,201 Tenure-stream 0 NCIC $1,968,025 Career Awards 73 HLTH CAN $501,716 With Research Funds MOH $453,356 Primary Appointments 306 HSFO/C $7,016,595 Cross Appointments n/a SSHRC $0 Studentship Awards: Industry $18,744,586 Supervised by Primary Appt 386 Other Sources $50,189,641 Fellows: Post-Doc. and Clin. 186












osteoporosis, musculoskeletal disease in the community & work force. - Text last updated March 2007

33




Total Number of Awards: 139 Primary Appointments 24 On Campus 15 Off Campus 9 Cross Appointments 14 CIHR $2,564,213 Tenured 6 NSERC $677,650 Tenure-stream 3 NCIC $82,000 Career Awards 3 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 19 HSFO/C $0 Cross Appointments unk SSHRC $40,000 Studentship Awards: Industry $1,104,919 Supervised by Primary Appt 65 Other Sources $2,262,399 Fellows: Post-Doc. and Clin. 5


34





Overall Research Objective : To achieve International recognition as a centre of excellence in women’s health research Current Major Areas of Research : • Clinical and basic perinatology • Control of parturition • Gynecologic cancers • Health services and health outcomes • Medical education • Minimally-invasive surgery • Molecular control of early fetal and placental growth • Multicentre perinatal randomized controlled trials • Paediatric and adolescent gynecology • Reproductive biology • Urogynecology and pelvic floor disorders • Developmental origins of adult health and disease - Text last updated March 2007

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Total Number of Awards: 244 Primary Appointments 25 On Campus 25 Off Campus unk Cross Appointments 1 CIHR $342,309 Tenured 5 NSERC $13,500 Tenure-stream 3 NCIC $0 Career Awards 1 HLTH CAN $0 With Research Funds MOH $366,390 Primary Appointments 16 HSFO/C $0 Cross Appointments n/a SSHRC $116,859 Studentship Awards: Industry $0 Supervised by Primary Appt 195 Other Sources $1,950,017 Fellows: Post-Doc. and Clin. 2 Overall Research Objective : The Department of Occupational Science and Occupational Therapy will focus its science on advancing the knowledge of occupation and its enablement. The systematic study of daily occupations and their meanings in the lives of people of all ages and abilities will serve to improve the life and well being of individuals, families, groups, communities and societies, breaking through barriers encountered in all aspects of daily living. Current Major Areas of Research :
















R. Stack Fieldwork education and assessment - Text last updated February 2007

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Total Number of Awards: 95 Primary Appointments 89 On Campus 2 Off Campus 87 Cross Appointments 12 CIHR $901,023 Tenured 1 NSERC $0 Tenure-stream 0 NCIC $0 Career Awards 3 HLTH CAN $0 With Research Funds MOH $1,217,247 Primary Appointments 17 HSFO/C $3,500 Cross Appointments 3 SSHRC $0 Studentship Awards: Industry $672,694 Supervised by Primary Appt 32 Other Sources $2,732,454 Fellows: Post-Doc. and Clin. 15


37




Total Number of Awards: 16 Primary Appointments 74 On Campus 0 Off Campus 74 Cross Appointments 24 CIHR $184,835 Tenured 2 NSERC $23,000 Tenure-stream 0 NCIC $0 Career Awards HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 6 HSFO/C $0 Cross Appointments 3 SSHRC $0 Studentship Awards: Industry $369,219 Supervised by Primary Appt 5 Other Sources $361,932 Fellows: Post-Doc. and Clin. 1

Overall Research Objective : To further our basic understanding of the inner ear, upper respiratory tract, and disorders of the neck and skull base. Current Major Areas of Research : • Auditory physiology and pathophysiology • Cochlear implants: basic and applied issues • Head and neck oncology: treatment and epidemiology • Hearing loss and associated communication disorders • Laryngeal cancer histopathology • Neonatal hearing loss • Psychoacoustics • Temporal bone histopathology • Upper respiratory tract • Vestibular and oculomotor topics: clinical and basic - Text last updated March 2006

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Total Number of Awards: 520 Primary Appointments 346 On Campus 0 Off Campus 346 Cross Appointments 29 CIHR $18,859,839 Tenured 1 NSERC $55,220 Tenure-stream 0 NCIC $721,061 Career Awards 14 HLTH CAN $156,673 With Research Funds MOH $91,125 Primary Appointments 127 HSFO/C $1,042,307 Cross Appointments 0 SSHRC $0 Studentship Awards: Industry $2,101,384 Supervised by Primary Appt 128 Other Sources $18,111,126 Fellows: Post-Doc. and Clin. 71

Overall Research Objective : To study mechanisms of disease and health maintenance in infants and children utilizing molecular, biochemical and epidemiological methods. Current Major Areas of Research : • Brain and behavioural research • Cancer and blood research • Cardiovascular research • Cell biology • Developmental biology • Genetics and genomic biology • Infection, immunity, injury and repair research • Integrative biology • Metabolic research • Population health science • Structural biology and biochemistry - Text last updated March 2007

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Overall Research Objective : To investigate and understand the interaction of chemical compounds with living systems. To strengthen the department through the development of research related to the mechanisms of drug action and toxicity. Current Major Areas of Research : • Behavioural pharmacology and drug addiction • Biochemical and molecular pharmacology • Clinical pharmacology • Drug metabolism and distribution • Drug safety and toxicology • Neuropharmacology and psychopharmacology • Pharmacogenetics • Receptor pharmacology • Second messengers and signal transduction - Text last updated March 2007


40




Total Number of Awards: 254 Primary Appointments 21 On Campus 14 Off Campus 7 Cross Appointments 11 CIHR $621,391 Tenured 7 NSERC $26,400 Tenure-stream 0 NCIC $0 Career Awards 3 HLTH CAN $0 With Research Funds MOH $287,783 Primary Appointments 14 HSFO/C $235,885 Cross Appointments n/a SSHRC $0 Studentship Awards: Industry $0 Supervised by Primary Appt 225 Other Sources $1,457,444 Fellows: Post-Doc. and Clin. 8


continuum care - Text last updated March 2007

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Total Number of Awards: 303 Primary Appointments 45 On Campus 29 Off Campus 16 Cross Appointments 63 CIHR $6,438,719 Tenured 16 NSERC $539,408 Tenure-stream 4 NCIC $0 Career Awards 16 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 37 HSFO/C $927,378 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $120,095 Supervised by Primary Appt 163 Other Sources $7,495,691 Fellows: Post-Doc. and Clin. 103

Overall Research Objective : Key Priorities: a) To expand and enrich four key areas of basic research represented by our Platforms of Research (see below) and to integrate these basic research activities into the clinical and basic research objectives of our sister hospital based research institutions. A “research partnership” is defined as a mutually beneficial collaborative research link which includes sharing of personnel and resources between the Department of Physiology on one hand and another Research unit within the University of Toronto/ Health Care Research community b) An important aspect of our research partnerships is to provide an outstanding environment for postdoctoral and graduate trainees c) An important aspect of our research partnerships is to provide an outstanding environment for the basic science training of clinician scientists d) A key priority of our research efforts is aimed at providing specialized undergraduate teaching to Arts and Sciences students with the objective of attracting the very best candidate for graduate level training in the Faculty of Medicine Key Challenges: a) To develop strategies that define academic and research partnerships between Departmental Research Platforms and other organizations within the University of Toronto/ Health Care Complex b) To expand competitive funding for research and training initiatives involving members of the Department of Physiology and our active research partners c) To recruit top research scientists to the full extent of our fiscal and physical resources and to maintain the Department of Physiology at the leading edge of international research. To maintain and enhance the infrastructure support from sources external to the direct budget of the Department Current Major Areas of Research : The following describes our plans for introduction of Research Platforms with sub-interest groups. Proposed Research Platforms: 1. Cardiovascular & Respiratory Science: http://www.uoftphysiology.com/faculty/programs/divisionDetails.cfm?division=6&from=listing 2. Endocrinology & Diabetes: http://www.uoftphysiology.com/faculty/programs/divisionDetails.cfm?division=5&from=listing 3. Brain & Behaviour: The Neurosciences: http://www.uoftphysiology.com/faculty/programs/divisionDetails.cfm?division=7&from=listing 4. Reproduction and Development: http://www.uoftphysiology.com/faculty/programs/divisionDetails.cfm?division=9&from=listing - Text last updated March 2007

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Total Number of Awards: 316 Primary Appointments 262 On Campus 51 Off Campus 211 Cross Appointments 147 CIHR $7,601,776 Tenured 20 NSERC $161,200 Tenure-stream 4 NCIC $0 Career Awards 12 HLTH CAN $389,788 With Research Funds MOH $4,140,654 Primary Appointments 73 HSFO/C $264,779 Cross Appointments unk SSHRC $275,672 Studentship Awards: Industry $224,000 Supervised by Primary Appt 138 Other Sources $14,082,907 Fellows: Post-Doc. and Clin. 20


infectious disease, chronic disease(eg. Arthritis, diabetes), accidents and injuries • Gerontology health and aging • Health professions and organizations • Health promotion and disease prevention • Methodological research in epidemiology, biostatistics and demography • Methodology: qualitative, quantitative, evaluation • Occupational and environmental health • Prevention of transmission of HIV/AIDS - Text last updated March 2007

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Total Number of Awards: 103 Primary Appointments 117 On Campus 0 Off Campus 117 Cross Appointments 6 CIHR $840,682 Tenured 0 NSERC $145,000 Tenure-stream 0 NCIC $731,818 Career Awards 3 HLTH CAN $0 With Research Funds MOH $305,125 Primary Appointments 30 HSFO/C $0 Cross Appointments 3 SSHRC $0 Studentship Awards: Industry $1,885,404 Supervised by Primary Appt 30 Other Sources $7,935,408 Fellows: Post-Doc. and Clin. 16

Overall Research Objective : Excellence in clinical and translational, basic science, and physics and imaging research related to radiation medicine. Current Major Areas of Research : • Molecular radiation biology of tumour and normal tissues • Image guided radiation therapy • Clinical trials • Tumour microenvironment and treatment outcome • Health services research For more information about the Department of Radiation Oncology contact: Dr. Anthony Fyles 416-946-6522 [email protected] - Text last updated March 2007

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Total Number of Awards: 155 Primary Appointments 10 On Campus 10 Off Campus 0 Cross Appointments 6 CIHR $291,754 Tenured 6 NSERC $29,789 Tenure-stream 3 NCIC $0 Career Awards 2 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 12 HSFO/C $110,885 Cross Appointments 3 SSHRC $40,859 Studentship Awards: Industry $0 Supervised by Primary Appt 133 Other Sources $983,322 Fellows: Post-Doc. and Clin. 2

Overall Research Objective : To advance knowledge of the neurological, behavioural, and social aspects of communication and swallowing. There are two primary foci: normal and disordered speech and swallowing, and language development and disorders across the lifespan. Research linkages have been forged through collaborative projects with engineering, neurological imaging, dentistry, linguistics, psychiatry and gastroenterology among others. Another research objective is to develop improved models of clinical management of communication disorders. Clinical research is being undertaken in the areas of augmentative and alternative communication, speech fluency, developmental language disorders, hearing loss, acquired aphasia and apraxia of speech among others. Current Major Areas of Research : Members of the Graduate Department of Speech-Language Pathology pursue research in the following major areas, each represented by a contact person identified below. For more information about our three graduate programs and a detailed list of faculty and their research, please inquire at 500 University Avenue, 10th Floor. Motor speech disorders and swallowing C. Steele 978-8330 Developmental speech and language disorders L. Girolametto 978-3353 Acquired language disorders (aphasia and dementia) E. Rochon 978-8332 C. Leonard 978-8332 Voice and resonance disorders T. Bressmann 978-7088 Speech motor control and stuttering L. De Nil 978-1789 Augmentative and alternative communication B. O’Keefe 978-6890 Developmental speech and language disorders C. Johnson 978-8331 Speech physiology and speech motor control P. Van Lieshout 978-8334 Childhood hearing loss A. Eriks-Brophy 946-8633 Swallowing R. Matino 946-8644 Stuttering R. Kroll 978-1789 International Rehabilitation P. Parnes 946-8556 Aphasia Treatment Outcomes A. Kagan 978-2770 - Text last updated March 2007

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DEPARTMENT: Surgery


Total Number of Awards: 497 Primary Appointments 326 On Campus 7 Off Campus 319 Cross Appointments 58 CIHR $7,002,811 Tenured 3 NSERC $281,793 Tenure-stream 0 NCIC $1,493,720 Career Awards 16 HLTH CAN $0 With Research Funds MOH $169,175 Primary Appointments 127 HSFO/C $1,740,870 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $4,628,539 Supervised by Primary Appt 126 Other Sources $19,024,942 Fellows: Post-Doc. and Clin. 107


World countries) - Text last updated March 2007

1 FMRO-calculated values presented. Department-provided numbers (2005-06)are as follows: Total Research Funding: $45,245,894; Total Awards: 480; CIHR: $8,978,057; NSERC: $219,725; NCIC: $2,194,400; OMHLTC: $ 760,375; HSFO/C: $1,682,505; Industry: $10,181,664; Other Sources: $21,229,168

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48








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Total Number of Awards: 28 Research Funds 12 Career Awards 2 CIHR $1,555,498 Studentship Grant Awards: NSERC $45,500 NCIC $0 Supervised by Investigator 4 HLTH CAN $0 MOH $0 Fellows: HSFO/C $1,331,694 SSHRC $0 Post-Doc. and Clin. 9 Industry $80,996 Other Sources $568,818


50




Total Number of Awards: 22 Research Funds 10 Career Awards 2 CIHR $81,053 Studentship Grant Awards: NSERC $25,415 NCIC $0 Supervised by Investigator 1 HLTH CAN $0 MOH $0 Fellows: HSFO/C $0 SSHRC $0 Post-Doc. and Clin. 1 Industry $28,189 Other Sources $549,904


51




Total Number of Awards: 243 Research Funds 87 Career Awards 16 CIHR $5,250,936 Studentship Grant Awards: NSERC $50,706 NCIC $0 Supervised by Investigator 29 HLTH CAN $5,934,047 MOH $463,324 Fellows: HSFO/C $75,723 SSHRC $238,776 Post-Doc. and Clin. 47 Industry $3,079,084 Other Sources $13,758,321


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Total Number of Awards: 1036 Research Funds 266 Career Awards 46 CIHR $23,373,684 Studentship Grant Awards: NSERC $409,823 NCIC $3,519,879 Supervised by Investigator 247 HLTH CAN $156,673 MOH $191,125 Fellows: HSFO/C $2,409,800 SSHRC $0 Post-Doc. and Clin. 265 Industry $4,317,206 Other Sources $66,119,698


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Total Number of Awards: 435 Research Funds 100 Career Awards 19 CIHR $15,182,314 Studentship Grant Awards: NSERC $433,346 NCIC $4,316,927 Supervised by Investigator 49 HLTH CAN $1,870 MOH $42,400 Fellows: HSFO/C $962,447 SSHRC $0 Post-Doc. and Clin. 152 Industry $5,579,755 Other Sources $21,983,521


54




Total Number of Awards: 688 Research Funds 164 Career Awards 28 CIHR $7,100,876 Studentship Grant Awards: NSERC $186,000 NCIC $42,688 Supervised by Investigator 79 HLTH CAN $607,039 MOH $2,537,611 Fellows: HSFO/C $986,709 SSHRC $0 Post-Doc. and Clin. 27 Industry $8,518,167 Other Sources $16,846,783


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HOSPITAL: Sunnybrook Health Sciences Centre: Orthopaedic and Arthritic Site


Total Number of Awards: 2 Research Funds 1 Career Awards CIHR $50,833 Studentship Grant Awards: NSERC $0 NCIC $0 Supervised by Investigator 1 HLTH CAN $0 MOH $0 Fellows: HSFO/C $0 SSHRC $0 Post-Doc. and Clin. no data Industry $0 Other Sources $78,000


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HOSPITAL: Sunnybrook Health Sciences Centre : Sunnnybrook Site


Total Number of Awards: 383 Research Funds 133 Career Awards 28 CIHR $12,779,805 Studentship Grant Awards: NSERC $246,250 NCIC $3,449,737 Supervised by Investigator 59 HLTH CAN $0 MOH $2,000,898 Fellows: HSFO/C $3,035,920 SSHRC $0 Post-Doc. and Clin. 89 Industry $2,375,194 Other Sources $36,853,159






57




Total Number of Awards: 62 Research Funds 23 Career Awards CIHR $812,902 Studentship Grant Awards: NSERC $112,102 NCIC $0 Supervised by Investigator 10 HLTH CAN $0 MOH $3,387,779 Fellows: HSFO/C $177,681 SSHRC $0 Post-Doc. and Clin. 28 Industry $52,292 Other Sources $5,529,003


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HOSPITAL: Women’s College Hospital


Total Number of Awards: 25 Research Funds 13 Career Awards 2 CIHR $2,138,833 Studentship Grant Awards: NSERC $0 NCIC $0 Supervised by Investigator 2 HLTH CAN $0 MOH $0 Fellows: HSFO/C $0 SSHRC $35,000 Post-Doc. and Clin. no data Industry $0 Other Sources $2,003,553


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Other Participants : • Canadian Diabetes Association • TriHospital Diabetes Education Centre • Samuel Lunenfeld Research Institute • Hospital for Sick Children Research Institute • Toronto General Research Institute Overall Research Objective : To foster programs of research, education and patient care in diabetes at the University of Toronto and its affiliated hospitals. To develop an endowment to support the activities of the Centre and to establish new research programs in areas related to diabetes in a number of clinical and basic sciences departments of the Faculty. Current Major Areas of Research : • Atherosclerosis • Clinical trials • Complications of diabetes • Diabetic nephropathy • Genetics of diabetes • Glucagon related peptides • Gut hormones • Immunology of diabetes • Insulin secretion • Insulin signaling • Integrative biology • Lipoprotein kinetics • Membrane biology • Molecular biology • Molecular genetics and evolution - Text last updated April 2007

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CENTRE: Joint Centre for Bioethics The University of Toronto Joint Centre for Bioethics is a partnership among the University of Toronto, Baycrest Centre for Geriatric Care, Bloorview Kids Rehab, Centre for Addiction and Mental Health, Centre for Clinical Ethics of Providence Centre (a shared service of Providence Healthcare, St. Joseph’s Health Centre and St. Michael’s Hospital), The Hospital for Sick Children, Humber River Regional Hospital, Mount Sinai Hospital, North York General Hospital, Ontatrio Genomics Institute, Sunnybrook Health Sciences Centre, Toronto Community Care Access Centre, Toronto East General Hospital, Toronto Rehabilitation Institute, Trillium Health Centre and University Health Network (Princess Margaret Hospital, Toronto General Hospital, and Toronto Western Hospital) . The mission of the Joint Centre is to provide leadership in bioethics research, education and clinical activities. Students, Research Assistants and Fellows : The Joint Centre for Bioethics has a formal doctoral-stream Collaborative Program in Bioethics through the School of Graduate Studies. The participating graduate units are: Department of Health Policy, Management and Evaluation, Institute of Medical Science, Faculty of Law, Faculty of Nursing, Department of Philosophy, Department of Public Health Sciences and Department for the Study of Religion. The Joint Centre for Bioethics also has a professional MHSc degree in Bioethics through the Institute of Medical Science. Participating Departments in the Faculty : Almost all the departments in the Faculty participate in the Joint Centre for Bioethics. There is a clinical ethics fellowship and research grants support fellows, graduate students and research associates and assistants in specific projects. Other Participating Faculties and Departments : Arts and Science, Law, Management, and Nursing Overall Research Objective : To foster interdisciplinary research and scholarship, link education to research, and disseminate research findings to improve policies and practices. Current Major Areas of Research : • Canadian Program on Genomics and Global Health • Canadian Priority Setting Research Network • Organizational Ethics Research Group • Project to Examine Effectiveness in Clinical Ethics • Public Health Ethics Interest Group • Rehab and Continuing Care Ethics Research Group • - Text last updated April 2007

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Faculty of Applied Sciences & Engineering • Department of Chemical Engineering & Applied Chemistry • Department of Electrical & Computer Engineering Faculty of Arts & Science • Department of Computer Science • Department of Chemistry






- Text last updated April 2007

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CENTRE: Clinical Science Division Academic Staff : 30 Students & Fellows : Graduate Students 53 Post-doctoral & Clinical Research Fellows 21 Participating Departments in the Faculty : • Medicine • Surgery Overall Research Objective : To foster a strong intellectual environment for clinician-scientists and basic scientists to undertake research programs alone, or in collaboration with one of the major research groupings and to provide a superior milieu for the training of research fellows and graduate students. Current Major Areas of Research : • Molecular Medicine Program • Cardiovascular sciences • Group in Membrane Biology • Gastroenterology/Nutrition • Hematology/Oncology • Infectious diseases/HIV • Renal physiology/pathophysiology • Respiratory sciences - Text last updated April 2007

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Other Participating Faculties & Departments : OISE/UT, Library and Information Science, Institute for Medical Science, Standardized Patient Program, Surgical Skills Centre at Mount Sinai Hospital, Centre for Faculty Development at St. Michael’s Hospital, Program in eHealth Innovation, Faculty of Medicine Acadamies; Faculty of Nursing, Faculty of Pharmacy, Departments of Kinesiology, Psychology, Sociology, English and Engineering, Michener Institute. Other Participants : Ontario Medical Education Network, (McMaster University, Queen’s University, University of Ottawa, University of Western Ontario and Northern Ontario Medical School). Addis Ababa University in Ethiopia, Technion Medical School, Haifa, Israel and Imperial College, London, England. Participating Hospitals : All teaching hospitals affiliated with the University of Toronto. Overall Research Objective : To advance healthcare education and practice through research. Current Major Areas of Research : Programs of research which are drawn from: learners and learning environments and their evaluation and improvement, teachers and teaching evaluation and improvement, informatics in health professional education, interprofessional skills including team work communications, factors affecting diagnostic decision making, the psychometrics of performance-based assessment and the sociology of health professional education research, professionalism and healthcare delivery, computer assisted instruction, clinical and technical skills simulation and assessment, communication skills simulation and assessment, curriculum development and evaluation, interdisciplinary projects in cognitive sciences regarding clinical problem solving, critical thinking and memory, patient safety and medical error, the development of and changes in sciences, Health Sciences Faculties collaborative projects related to educational and practice outcomes of health professional education and faculty development. - Text last updated April 2007

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Studies • Department of Sociology • Division of the Environment/Innis

College,


Participating Organizations : • Centre for Addiction & Mental Health • Promotion & Programs Branch, Ontario

Regional Office, Public Health Agency of Canada

• Ontario Prevention Clearinghouse • Ministry of Health Promotion • Toronto Public Health • Centre for Urban Health Initiatives • Centre for International Health

• Canadian Society for International Health

• IUHPE-International Union of Health Promotion and Education

• PAHO-Pan American Health Organization

• WHO-World Health Organization

Overall Research Objective : To develop a program of applied evaluation research in health promotion provincially, nationally and internationally. Current Major Areas of Research : • Youth in primary health care • Youth and health in the Ukraine • Health Literacy • Mental health promotion • Workplace health promotion • Economic Evaluation in health promotion - Text last updated April 2007

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CENTRE: Centre for International Health

The Centre for International Health is committed to improving the 10/90 gap in global health research, where 90% of the world’s health research is focused on 10% of the world’s health burden, by developing and facilitating multidisciplinary global health research and education opportunities with departments in the Faculty of Medicine, the University of Toronto, international universities and organizations. The CIH enables global health research, education and advocacy. Collaborations continue with the Centre for Global Health Research, CISEPO, Office of International Surgery, Sprinkles, Sickkids International, the Global Pediatric Research Program and the International Centre for Disability and Rehabilitation. The CIH has developed into a national and international preeminent centre for scholarship and teaching. It enables and facilitates ideas, research and education to advance the University’s research priority. In 2005-06 the CIH completed its evaluation of the Southern Africa AIDS Trust (SAT) for CIDA; began a five year AUCC/CIDA funded (Tier 2) collaboration with the University of Port Harcourt, Nigeria to research human resources needed to combat HIV/AIDS; continued research on rural health system reform through collaborations with the China National Health Economics Institute and Kunming Medical College; collaborated with Capital Medical University in Beijing to study and implement the teaching of family/general practice medicine and facilitated student initiated primary health care research in Cambodia, at our field station program and in hospitals in the capital city. The CIH began to host four post doctoral students: Dr. Daniel Hollenberg studying integrated medicine in Canada; Dr. Daniel Sahleyesus studying HIV/AIDS orphans and vulnerable children in Ethiopia; Dr. Stephanie Nixon studying HIV/AIDS at the Health Economics Research Division at the University of Kwazulu Natal in Durban, South Africa; Dr. Youde Guo, from Fudan University, Shanghai, studying health policy and organization in Canada. Participating Departments and Units in the Faculty of Medicine (selected): • Family & Community Medicine • Health Policy, Management & Evaluation • Otolaryngology • Pediatrics • Psychiatry • Public Health Sciences • Rehabilitation Sciences • Surgery • Obstetrics and Gynaecology

• Medicine including Infectious Disease & Emergency




Science




Overall Research Objective: Implementing, facilitating and supporting multidisciplinary research focused on issues of relating to health problems affecting the world’s poorest and most vulnerable. Current Major Areas of Research: • Primary Health Care Development – Cambodia • Rural Health System Reform – China • Urban Community Health Development China

• HIV/AIDS –Zambia, Namibia,Tanzania, Nigeria and Kenya; South Africa, Ethiopia and Malawi

With funds from the Medical Alumni Association, the CIH sends students to international sites to carry out research and elective projects. • Total Number of Studentship MAA Research Awards =13 • Total Number of Overseas Electives = 12 • Total Number of Resident Awards=20 • Post-doctoral or Clinical Fellows (involved in research) = 4 For more information, visit the Centre’s website at: http://intlhealth.med.utoronto.ca/ - Text last updated April 2007

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Engineering





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degenerations, ALS, Parkinson’s Disease • Brain trophic factors and neuron rescue • Cytoskeletal proteins in health and neurodegenerative disease • Gene expression in Alzheimer's Disease • Genetic basis of familial neurodegenerative disease • Genetics of Amyotrophic Lateral Sclerosis (Lou Gehrig’s Disease) • Genetics of Parkinson’s Disease • Genetics of spinocerebellar ataxias • Pharmacokinetics of anti-dementia drugs • Protein structure, protein-protein interactions • Molecular and cell biology of amyloid, α-synuclein, tau, progranulin, TBP43, peripherin • Developmental neurobiology • Axon guidance and sprouting - Text last updated April 2007

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INSTITUTE: Institute of Medical Science Academic Staff : 529 Participating Departments in the Faculty : The Institute of Medical Science is the graduate unit for all the clinical departments in the Faculty of Medicine (with the exception of Laboratory Medicine & Pathobiology). Its multidisciplinary faculty represents virtually every department in the Faculty of Medicine and includes members from other faculties across the U of T campus. The faculty and students are located on the University campus in the Medical Sciences Building, as well as in the various Hospital Research Institutes that form the University of Toronto Health Sciences Complex. Overall Research Objective : To provide structured education and training of individuals for research careers in traditional biomedical sciences (molecular/cellular and integrative biology) as well as in clinical investigation/health services research and bioethics. This is fulfilled by provision of programmes at the graduate level, and also includes participation in the MD/PhD programme. The emphasis is on the development of research skills backed by broad exposure to medical science and biology that will lead the student to independent scholarship and inquiry. The programmes are directed to both professional and non-professional students, although a special mission of the IMS is the training of clinician scientists. The IMS also participates in the Royal College of Physicians and Surgeons Clinician Investigator Program, and also houses the Masters of Science in Biomedical Communication, and the Masters of Health Science & Bioethics. - Text last updated April 2007

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INSTITUTE: Institute for Work & Health Overall Research Objective : The mission of the Institute for Work & Health is to research and promote new ways to prevent workplace disability, improve treatment, optimal recovery and safe return to work. The Institute is dedicated to research and to the transfer of research results into practice by the healthcare providers, workplace parties and other policy makers. Through the Institute’s association with the University community, and the Institute’s access to workplaces and key sources of data, it has also become an important training ground for graduate students and young investigators. Current Major Areas of Research : • Behavioural consequences of insurance and regulation • Epidemiology of disability • Evidence-based practice • Labour market experiences and health • Measurement of health and function • Prevention of Disability • Statistical methods • Workplace interventions and evaluations - Text last updated April 2007

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PROGRAM: Cardiovascular Collaborative Program Academic Staff : 77 Graduate Students : 36 Participating Departments and Units : • Anesthesia • Dentistry • Exercise Science • Health Policy, Mgmt & Evaluation • Inst. of Biomaterials & Biomed Eng • Inst. of Medical Science • Laboratory Medicine & Pathobiology • Medical Biophysics • Medicine • Nursing • Pharmaceutical Sciences • Pharmacology • Physiology • Public Health Sciences • Rehabilitation Science • Social Work • Surgery Overall Research Objective : To develop cooperative and joint graduate teaching and research across departmental boundaries within the Faculty of Medicine and with the Faculty of Physical Education & Health to enhance the visibility of cardiovascular studies and to facilitate interdisciplinary training and research. Current Major Areas of Research : • Biochemistry of membrane lipids • Cyanotic heart disease • Exercise science • Gender related to cardiovascular studies • Gene expression • Growth factors • Haematology • Heart/lung/kidney • Hypertension/atherosclerosis • Hypertrophy/cardiomyopathy • Infarction/heart failure • Molecular biology • Myocardial protection • Paediatric/fetal development • Periodontal vascularization • Retinal blood flow • Sympathetic nervous system • Transplantation • Vascular haemodynamics and mineralization - Text last updated April 2007

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Sites : Mount Sinai Hospital, St. Michael’s Hospital, University Health Network and Medical Sciences Building, University of Toronto. Overall Research Objective : To build a Centre of the highest clinical and academic quality for patient care, research and education in the field of immunology and transplantation. The program is founded on the belief that multidisciplinary collaboration and effective communication among team members will support continuous quality improvement. Current Major Areas of Research : Research constitutes a major thrust of the Multi Organ Transplant Program with activities in both basic science of immunology/transplantation as well as the clinical outcomes research. A thematic approach to research has now been adopted with basic science programs in the following areas: • Mechanisms of antigen recognition and rejection • Studies of organ preservation injury • Cellular and molecular mechanisms of organ injury • Identification and characterization of new immunosuppressive agents • Mechanism of tolerance induction • Xenotransplantation • Stem cell technology • In vitro organogenesis • Pathogenesis of infectious disease in the immunocompromised host • Gene therapy • Genomics/proteomics As part of the program we have a CIHR funded Training program in Regenerative Medicine www.regenmedcanada.com (course and funding for fellows and students). For applications e-mail: [email protected] - Text last updated April 2007

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INDUSTRIAL FUNDING SOURCES We would like to acknowledge the sponsorship of our industrial partners. Total grants received: Greater than $1,000,000 AstraZeneca Canada Inc. Boston Scientific Ltd. GlaxoSmithKline Inc. Merck Frosst Canada Ltd.

Novartis Pharmaceuticals Canada Inc. Pfizer Canada Inc. Sanofi-Aventis (Canada)

Between $500,000 and $99,999 AMGEN Inc. Advance Therapeutics Apotex Inc. Bayer Inc. Bristol-Myers Squibb Pharmaceutical Group

(Canada) Eli Lilly Canada Inc. GlaxoSmithKline (Canada)

Janssen-Ortho Inc. (Canada) LKSF Lundbeck Canada Inc Northern Therapeutics Inc. Ortho Biotech, a Division of Jansenn-Ortho Inc. Roche Diagnostic GmbH Schering Canada Inc. Trillium Therapeutics Inc.

Between $200,000 and $499,999 Abbott Laboratories Ltd. Aegera Therapeutics Inc Allergan Inc. Astellas Pharma Canada, Inc. BioChem Therapeutic Inc. BioMs Technology Corporation Biogen Idec, Inc. Bristol-Myers Squibb Canada Inc. Duchesnay Inc. Elekta Instrument AB Elekta Ltd. GE Healthcare Genentech Inc. (US) General Mills, Inc. Genzyme Corporation Gilead Sciences Guidant Canada Hoffmann-La Roche Inc. (Canada)?? Hoffmann-La Roche Ltd. Inco Ltd.

Insception Biosciences Inc. InterMune, Inc. Johnson & Johnson Loblaw Companies Ltd. Merck & Co., Inc. Novartis Institute for Biomedical Research OncoTherapeutics Inc. OrbusNeich Otsuka America Pharmaceutical Inc. Philips Electronics North America Corporation Proteolix Inc. SAIC - Frederick, Inc. Sanofi-Synthelabo Inc. Signal Pharmaceuticals, LLC Structural Genomics Consortium The Multiple Myeloma Research Foundation Varian Medical Systems, Inc. Wyeth-Ayerst Canada Inc. YYZ Pharmatech Inc.

Between $100,000 and $199,999 Afference Therapeutics Inc. Amorfix Life Science Ltd. Bell Canada BioMimetic Pharmaceuticals Inc Boehringer Ingelheim (Canada) Ltd. Boehringer Ingelheim Pharmaceuticals Inc. Bristol-Myers Squibb Foundation Inc. Burroughs Wellcome Fund CSL Limited Cangene Corporation Charles River Laboratories International, Inc. Cyclacel Ltd

Dompe S.p.A. Eastman Kodak Company Eli Lilly and Company H. Lundbeck A/S Human Genome Sciences, Inc. Idenix Pharmaceuticals, Inc. Johnson & Johnson Services Inc KGK Synergize Inc Maquet - Dynamed Medicure, Inc. Medtronic of Canada Ltd Metabolic Pharmaceutical Ltd

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Between $100,000 and $199,999 (continued) MethylGene Inc. MetriGenix Corporation New England Research Institutes Novartis Pharma AG Onyx Pharmaceuticals Inc. Organon Canada Ltd. PAREXEL International Pfizer Inc. Philips Electronics Ltd RaySearch Medical AB Sanofi Winthrop Inc.

Sanofi-Synthelabo Inc. Sepsis Inc. Serono Canada, Inc. St. Jude Medical, Inc. Talecris Biotherapeutics, Inc. Teva Neuroscience, Inc. Transition Therapeutics Inc. Xillix Technologies Corp. YM BioSciences Inc. Z-Tech (Canada) Inc.

Less than $100,000 ALTANA Pharma Inc. AMGEN Canada Inc. Abbott Spine Inc. Acorda Therapeutics Inc. Actelion Pharmaceuticals Canada Inc. Actelion Pharmaceuticals Ltd Advanced Neuromodulation Systems Alavita Pharmaceuticals Inc. Alcatel Canada Inc. Alcon Inc. Alcon Research Ltd Altus Pharmaceuticals Inc. American Cystoscopes Makers Inc. American Medical Systems Inc. Amicus Therapeutics Arginox Pharmaceuticals Inc. Array Biopharma Aryx Therapeutics, Inc. AtheroGencis Inc. Axcan Pharma Inc. Axio Research Company Bausch & Lomb Inc. Baxter Healthcare Corp (Canada) Beckman Coulter, Inc. Berlex Canada Inc. BioDiscovery Toronto BioMarin Pharmaceutical Inc Bristol-Myers Squibb Med Imaging Burroughs Wellcome Inc. CAD Sciences CELLutions Biosystems Inc. CV Therapeutics Inc Cardiome Pharma Group Celgene Corporation Cell Genesys Inc. Centocor, Inc. ChemBridge Research Lab. Inc. Cochlear Americas Cook (Canada) Inc. Cordis Corporation Covalon Technologies Inc.

Daiichi Sankyo, Inc. Danone Institute of Canada DebioVision Inc. Edwards Lifesciences ehn inc. Eisai Medical Research Inc. Elastin Products Company, Inc. Epix Pharmaceuticals, Inc. Estracure Inc ethica Clinical Research Inc Exponential Biotherapies Inc. Expression Diagnostics Ferring Pharmaceuticals Inc. Field Metrica Inc. GTx Gebauer Company Gemin X Biotechnologies Inc. GeneOhm Sciences, Canada Inc. Genesis Bio-Pharmaceuticals Gentium S.p.A. Genzyme Corporation GlaxoSmithKline Inc. Glycaemic Index Testing Inc. H.J. Heinz Company of Canada Ltd. Hemosol Inc. Hogg Robinson Canada Inc. Holburn Research Services Inc IBEX Technologies ImClone Systems Inc. Immunex Corporation Intercytex Ltd Interface Biologics Inc. International Medical Innovations Inc. Isotechnika Inc. Kinetic Concepts, Inc. Kraft Canada Inc. Lightsciences Corporation Lumen Therapeutics Luminex Molecular Diagnostics Lupus Clinical Trials Consortium, Inc. MDS Pharma Services

85


Less than $100,000 (continued)MIGENIX, Inc. Mandarin Restaurant Franchise Corporation MedImmune, Inc. MedPharmGene Inc. Medpace Inc. Medtronic of Canada Ltd. MetRegen Molecular Insight Pharma Inc. Molecular Templates Inc. NMT Medical Inc NPS Allelix Corporation Nestec Limited NociPharm Inc Novacea Novartis International AG Novartis Pharmaceuticals Corporation Novo Nordisk A/S Nuvelo, Inc. OrthoLogic Corporation (US) Ovation Pharmaceuticals Inc. PARI GmbH PDL BioPharma PPD Development, Inc. Petro-Canada Lubricants Pfizer Inc. Pharmacyclics Inc. Pharmaxis Ltd Procter & Gamble Pharmaceuticals Canada, Inc. Prometheus Laboraties Inc. Psiron Ltd Purdue Pharma L.P. Q-Med Scandinavia, Inc. R. W. Johnson Pharmaceutical Research Institute REATA Pharmaceuticals Replicor Inc

Respironics Inc Resverlogix Corporation Rimon Therapeutics Ltd. Roche Products Ltd Rome Foundation Sankyo Pharma Servier Canada Inc. Shire Pharmaceuticals Group plc Smith & Nephew (Canada) Smith and Nephew Richards, Inc Solvay Pharmaceuticals B.V. Spiration, Inc St. Jude Medical Canada, Inc. Steba Beheer NV StemCell Tecnologies Inc. Taro Pharmaceuticals Inc. The BioBalance Corporation The Emmes Corporation The Freedom Forum The Medicines Company Thoratec Corporation Tibotec Pharmaceuticals Ltd. Transkaryotic Therapies, Inc. Trudell Medical Group Tyco Healthcare Group LP Unilever Research Vlaardingen United Paragon Associates Inc. Valeant Pharmaceuticals International Vasogen Inc. Vion Pharmaceuticals Inc. Viventia Biotech ZIOPHARM Oncology Inc. ZOEGENE Corporation Zelos Therapeutics Inc

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Total grants received: Greater than $1,000,000 Anonymous Argonne National Laboratory Arthritis Society Association of Universities & Colleges of Canada Bill & Melinda Gates Foundation Canada Foundation For Innovation Canada Research Chairs Program Canadian Breast Cancer Foundation Canadian Breast Cancer Research Alliance Canadian Cystic Fibrosis Foundation Canadian Diabetes Association Cancer Care Ontario Government of Canada: Canada Research Chairs Government of the United States: National

Institutes of Health (US) Hospital for Sick Children Hospital for Sick Children Foundation Howard Hughes Medical Institute John P. Robarts Research Institute Juvenile Diabetes Research Foundation

International Lincy Foundation McLaughlin Centre for Molecular Medicine McMaster University Ministry of Health Promotion

Ministry of Research and Innnovation (Ontario) Mount Sinai Hospital Multiple Sclerosis Society of Canada Networks of Centres of Excellence: Canadian

Stroke Network (CSN) NeuroScience Canada Ontario Innovation Trust Ontario Innovation Trust Ontario Research And Development Challenge

Fund Ontario Genomics Institute Ontario Institute for Cancer Research Ontario Mental Health Foundation Ontario Neurotrauma Foundation Physicians' Services Inc. Foundation Private Individuals St Michael's Hospital St. Michael's Hospital The Ontario HIV Treatment Network University Health Network University of Toronto Various companies Various sponsors Workplace Safety and Insurance Board

Between $500,000 and $99,999 Amercian Type Culture Collection Cancer Research Society Inc. Cystic Fibrosis Foundation (US) Government of Canada: International

Development Research Centre Government of the United States: Office of Army

Research Kidney Foundation of Canada Leukemia & Lymphoma Society McGill University NCE: PrioNet National Alliance for Research on Schizophrenia

and Depression National Institute of Nutrition

Networks of Centres of Excellence: Canadian Network for Vaccines and Immunotherapeutics (CANVAC)

Networks of Centres of Excellence: Stem Cell Network (SCN)

Ontario Hospital Association Ontario Problem Gambling Research Centre Premier'S Research Excellence Award Stanford University Sunnybrook & Women's College Health Sciences

Centre The Susan G. Komen Breast Cancer Foundation University of Pittsburgh

Between $200,000 and $499,999 Alzheimer's Association Banting & Best Diabetes Centre Canadian Association of Radiation Oncologists Canadian Blood Services Canadian Foundation for AIDS Research

(CANFAR) Canadian Health Services Research Foundation

Canadian Patient Safety Institute Canadian Tobacco Control Research Initiative Cancer Care Ontario Case Western Reserve University City of Toronto Connaught Fund Crohn's & Colitis Foundation of Canada

87


Between $200,000 and $499,999 (continued) Douglas Hospital Research Centre Eye Institute of Canada Fraser Health Authority Genome Prairie Inc. Government of Canada: Canadian International

Development Agency Government of Canada: Public Works and

Government Services Canada Government of Ontario: Ministry of Education Government of the United States: National

Institute on Alcohol Abuse and Alcoholism Harvard University High Q Foundation, Inc. J.P. Bickell Foundation March of Dimes Birth Defects Foundation (U.S.) Mount Sinai Hospital Muscular Dystrophy Association (US) NCE: Allergy, Genes and Environmental Network National Childhood Cancer Foundation National Sanitarium Association Networks of Centres of Excellence: Advanced

Foods and Materials Network (AFMNet)

Networks of Centres of Excellence: Automobile of the 21st Century (AUTO 21)

Networks of Centres of Excellence: Canadian Arthritis Network (CAN)

Networks of Centres of Excellence: Mathematics of Information Technology & Complex Systems (MITACS)

Ontario Clinical Oncology Group Ontario Thoracic Society Prostate Cancer Research Foundation of Canada State University of New York/Albany The Breast Cancer Research Foundation The Change Foundation The Foundation Fighting Blindness - Canada Toronto Rehabilitation Institute U.S. Dept of Health and Human Services University of British Columbia University of California, San Franc University of Western Ontario York University

Between $100,000 and $199,999 ALS Society of Canada AllerGen NCE Alzheimer Society of Canada American Association for Thoracic Surgery American Health Assistance Foundation B.r.a.i.n. Child Barbara Keenan Foundation Bloorview Childrens Hospital Foundation Brigham and Women's Hospital CIHR Institute of Human Development Canadian Association of Gastroenterology Canadian Institute for Advanced Research Canadian Institute of Ukrainian Studies Canadian Lung Association Canadian Psychiatric Research Foundation Cancer Research Institute (US) Centre for Addiction and Mental Health Children's & Women's Health Centre of British

Columbia Children's Hospital of Denver Christopher Reeve Paralysis Foundation Columbia University New York Columbus Children's Research Inst Dalhousie University Desmoid Tumor Research Foundation Duke University Einstein College of Medicine Foundation Fighting Blindness Foundation for Lung Cancer Gebert-Ruf Foundation

Government of Canada: The Public health Agency of Canada


Government of the United States: Office of Army Research

Hamilton Health Sciences Corporation Human Frontier Science Program Organization Lance Armstrong Foundation Lawson Foundation Massachusetts General Hospital Maternal and Child Health Bureau Ministry of Citizenship and Immigration Networks of Centres of Excellence: Canadian

Institute for Photonic Innovation (CIPI) Ontario Centres of Excellence Ontario Centres of Excellence: Photonics

Research Ontario (PRO) Ontario Greenhouse Vegetable Paediatric Consultants Parkinson Foundation of Canada Queen's University Retinoblastoma Solutions Rett Syndrome Research Foundation Stanley Foundation The American Society of Clinical Oncology The EJLB Foundation The Hospital for Sick Children Psychiatry

Endowment Fund

88


The Michael J. Fox Foundation for Parkinson's Research

The Ontario Council on Gradual Studies The Provincial Centre of Excellence for Child and

Youth Mental Health The Rockefeller Foundation The Scottish Rite Charitable Foundation The Stanley Medical Research Institute

Universite de Shrebrooke University of Guelph University of Manitoba University of Massachusetts University of Ottawa Wellesley Central Health Corporation Yale University

Less than $100,000 AO North America Acadia University Alberta Heritage Foundation Alberta Heritage Foundation for Medical

Research Amalgamated Transit Union MS Amer Inst of Ultrasound in Med American Academy of Neurology Foundation American Association of Neurological Surgeons American Brain Tumor Association American College Radiology Imaging American College of Radiology American College of Surgeons American Foundation for Suicide Prevention American Soc of Plastic Surgeons American Society of Regional Anesth Amyotrophic Lateral Sclerosis Association (US) Animal Welfare Institute Arbeitsgemeinschaft Fur Osteosynthesefragen -

Association for the Study of Internal Fixation Arthritis Foundation Associated Medical Services, Inc. Association of Hemophilia Clinic Directors of

Canada Association of Medical Microbiology and

Infectious Disease Canada Back2Feet Inc. Banting Research Foundation Beatty Benaroya Research Institute at Virginia Mason Biotechnology and Biological Sciences Research

Institute Bloorview MacMillan Children's Ctr Bloorview MacMillan Children's Foundation Boston University C.R. Younger Foundation C17 research Network Calouste Gulbenkian Foundation Can. Mental Health Assoc. Canadian Agency for Drugs and Technologies in

Health Canadian Anaesthetists' Society Canadian Association of Emergency Physicians Canadian Cancer Etiology Research Network Canadian Council on Learning Canadian Dermatology Foundation

Canadian Food Inspection Agency Canadian Foundation for Dietetic Research Canadian Foundation for Women's Health Canadian Gene Cure Foundation Canadian HIV Trials Network Canadian Heart Research Centre Canadian Institute for Health Information Canadian Liver Foundation Canadian Occupational Therapy Foundation Canadian Paediatric Society Canadian Paraplegic Association Canadian Stroke Consortium Canadian Urologic Oncology Group Canadian Urology Research Consortium Centrum Foundation Children's Brain Tumor Foundation Children's Hospital of Eastern Ontario Children's Hospital of Philadelphia Children's Hospital of Pittsburgh Children's Memorial Research Center Children's Tumor Foundation Cincinnati Children's Hospital Medical Center Clarkson University Community Occupational Therapy Craig H. Neilsen Foundation Crohn's & Colitis Foundation of America, Inc. CureSearch Children's Oncology Group Dairy Farmers of Canada Dana Foundation Dana-Farber Cancer Institute Dartmouth College Dystonia Medical Research Foundation E.A. Baker Foundation of the CNIB Eastern Virginia Medical School Emory University Essel Foundation FWF Austrian Science Fund Fanconi Anemia Research Fund, Inc. Fowler Kennedy Sport Medicine Clinic Fragile X Research Foundation of Canada France-Canada Research Foundation Garrod Association George Washington University Glaucoma Research Society Global Alliance Improved Nutri Government of Canada: Canadian Heritage

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Less than $100,000 (continued) Government of Canada: Department of Foreign

Affairs & International Trade Government of Ontario: Ministry of Community,

Family & Children's Services Government of Ontario: Ministry of Energy Government of Quebec: SecrTtariat aux affaires

intergouvernementales canadiennes Government of the United States: Centers for

Disease Control and Prevention Government of the United States: Department of

Agriculture Government of the United States: Department of

Veterans Affairs HHT Foundation International Health Innovation Henrietta Banting Memorial Fund Henry White Kinnear Foundation Huntington's Disease Society of America ICON Inst. for Clinical Eval. Sciences Institute of Environmental Science and Research

Limited International Life Sciences Institute International Society for Clinical Densitometry Japan Diabetes Foundation Jewish Gen Hosp, McGill-CIHR Lakehead University Le Hopital Sainte-Justine Lesbian Health Fund Macula Vision Research Foundation Marie Curie Sklodowska Asso Medical Council of Canada Medical Univ of South Carolina Montreal Heart Institute Morehouse School of Medicine Motor Neurone Disease Association Mount Sinai School of Medicine Muscular Dystrophy Association of Canada National Ctr for Child Health Dev Natl Net Environ and Women's Health Networks of Centres of Excellence: Canadian


New York University North Simcoe Muskoka Local Health Integration

Network Northwestern University Obsessive Compulsive Foundation Ont.Federation of Cerebral Palsy Ontario Cancer Biomarker Network Ontario Federation Cerebral Palsy Ontario Health Quality Council Ontario Lung Association Ontario Lupus Association

Ontario Public Health Association Ontario Respiratory Care Society Ontario Tobacco Research Unit Org of Teratology Info Specialists Ortho Trauma Association Osteoporosis Society of Canada Otsuka Mayland Research Institute Ottawa Health Research Institute Pediatric Orthopaedic Society of Prostate Cancer Research Foundation Pulse Canada REMAD Foundation Limited RSNA Research and Education Fund Roswell Park Cancer Institute Royal Society of Canada Royal Women's Hospital Ryerson University Savoy Foundation Shwachman-Diamond Syndrome Found Society of Cardiovascular Anaesthesiologists Society of University Surgeons Southeast Regional Health Authority St Joseph Health Centre St. Joseph's Hosp & Med Centre (US) St. Jude Children's Research Hospital Sudbury & District Health Unit The Atkinson Charitable Foundation The Canadian Anesthesia Research Foundation The Canadian Chiropractic Research Foundation The Cleveland Clinic The Dr. Charles H. Best Foundation The Drummond Foundation The Francis Families Foundation The Gorbachev Foundation of North America The Hearing Foundation of Canada The James S. McDonnell Foundation The Jarislowsky Foundation The Leukemia & Lymphoma Society of Canada The Lustgarten Foundation for Pancreatic Cancer

Research The Montreal General Hospital The National Multiple Sclerosis Society The National Surgical Adjuvant Breast and Bowel

Project (NSABP) The Ottawa Hospital The Pediatric Brain Tumor Foundation of the

United States The Princess Margaret Hospital Foundation The Royal College of Physicians and Surgeons of

Canada The University of Texas The Workers' Compensation Board of British

Columbia Thrasher Research Fund

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Less than $100,000 (continued) Toronto Centre for Antimicrobial Research &

Evaluation Toronto Transit Commission Town of Oakville UWI Ctr for Environmental Dev't Union of British Columbia Municipalities United Mitochondrial Disease Founda Univ of Cincinnati Univ of Ottawa Heart Institute Universite De Montreal University Renal Research and Education

Association University of Florida University of Maryland

University of Medicine and Dentistr University of Michigan University of North Carolina (CH) University of P.E.I. University of Tennessee University of Texas at Dallas University of Utah University of Victoria University of Washington Universtiy of Kansas Medical Center Research

Institute Viron Therapeutics Inc. Washington University St Louis West Park Hospital Foundation

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Based on RIS data snapshot : 28 January 2009, 1236hrs

Version 1: April 1, 2009

PRODUCED BY: Office of the Vice Dean, Research and International Relations Faculty of Medicine University of Toronto http://www.medresearch.utoronto.ca/ Rooms 2331 - 2340 1 King’s College Circle Toronto, Ontario M5S 1A8 CANADA Contact person: GJ Baylon, MD Coordinator, Research Information (416) 978 – 8339 [email protected]







Source .................................................................................................................................. 19


Departmental Synopses Notes to Faculty of Medicine Departments...................................................................................... 20 Summary of Department research funding and personnel ............................................................. 21 Anesthesia........................................................................................................................................ 22 Banting and Best Department of Medical Research ....................................................................... 23 Biochemistry ..................................................................................................................................... 24 Family and Community Medicine..................................................................................................... 25 Health Policy, Management and Evaluation.................................................................................... 26 Immunology...................................................................................................................................... 27 Inst. of Biomaterials & Biomedical Engineering............................................................................... 28 Laboratory Medicine and Pathobiology ........................................................................................... 29 Medical Biophysics........................................................................................................................... 30 Molecular Genetics (formerly Medical Genetics & Microbiology).................................................... 31 Medical Imaging ............................................................................................................................... 32 Medicine ........................................................................................................................................... 33 Nutritional Sciences.......................................................................................................................... 34 Obstetrics and Gynaecology............................................................................................................ 35 Occupational Science & Occupational Therapy. ............................................................................. 36 Ophthalmology and Vision Sciences ............................................................................................... 37 Otolaryngology – Head and Neck Surgery ...................................................................................... 38 Paediatrics........................................................................................................................................ 39 Pharmacology and Toxicology......................................................................................................... 40 Physical Therapy.............................................................................................................................. 41 Physiology ........................................................................................................................................ 42 Psychiatry ......................................................................................................................................... 43 Public Health (Dalla Lana School of) ............................................................................................... 44 Radiation Oncology.......................................................................................................................... 45 Speech-Language Pathology........................................................................................................... 46 Surgery ............................................................................................................................................. 47 Affiliated Teaching Hospital Synopses Notes to the Affiliated Teaching Hospitals ....................................................................................... 48 Summary of Hospital research funding and personnel ................................................................... 49 Baycrest Centre for Geriatric Care................................................................................................... 50 Bloorview Kid’s Rehab .................................................................................................................... 51 Centre for Addiction and Mental Health........................................................................................... 52 The Hospital for Sick Children.......................................................................................................... 53 Mount Sinai Hospital ........................................................................................................................ 54 St. Michael’s Hospital ....................................................................................................................... 55


Sunnybrook Health Sciences Centre, Orthopaedic & Arthritic Site................................................. 56 Sunnybrook Health Sciences Centre, Sunnybrook Site.................................................................. 57 Toronto Rehabilitation Institute ........................................................................................................ 58 University Health Network................................................................................................................ 59 Women’s College Hospital ............................................................................................................... 60 Intra/Extradepartmental Centre, Group, Institute, and Program Synopses Notes to Summary of Intra/Extradepartmental Units....................................................................... 61 Banting and Best Diabetes Centre................................................................................................... 62 Joint Centre for Bioethics ................................................................................................................. 63 Terrence Donnelly Centre for Cellular & Biomolecular Research................................................... 64 Clinical Science Division .................................................................................................................. 65 The Wilson Centre for Research in Education ................................................................................ 66 Gage Occupational & Environmental Health Unit ........................................................................... 67 Centre for Health Promotion ............................................................................................................ 68 Centre for International Health ........................................................................................................ 69 R.S. McLaughlin Centre for Molecular Medicine ............................................................................. 70 Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research ........................ 71 Centre for Research in Neurodegenerative Diseases..................................................................... 72 Positron Emission Tomography (PET) Centre ................................................................................ 73 Centre for Sleep Research............................................................................................................... 74 Centre for the Study of Pain............................................................................................................. 75 Bone and Mineral Group .................................................................................................................. 76 Drug Safety Research Group........................................................................................................... 77 Institute of Medical Science ............................................................................................................. 78 Institute for Work & Health ............................................................................................................... 79 Cardiovascular Sciences (Collaborative Program).......................................................................... 80 Multi Organ Transplant Program...................................................................................................... 81 Program in Neuroscience................................................................................................................. 82 Structural Genomics Consortium..................................................................................................... 83 Industrial Funding Sources .............................................................................................................. 84 Other Funding Sources .................................................................................................................... 87


IV

MESSAGE FROM THE VICE DEAN, RESEARCH AND INTERNATIONAL RELATIONS The publication of this the 22nd edition of the Synopsis marks my seventh year as Vice Dean, Research and International Relations. It has been a pleasure to serve in this role. I am joined in this endeavor by my colleagues George Fantus, Associate Dean, Research, and Mingyao Liu, Director for International Research Relations. I wish to acknowledge the excellent contributions of GJ Baylon, Liz Fragnelli and Rosalind Waxman who collect and maintain our funding database and produce the reports for this very important document.

This synopsis highlights research funding and activities for the period 2007/08 by Faculty of Medicine researchers situated on campus and at the research institutes of the following 10 fully affiliated hospitals: Baycrest Centre for Geriatric Care, Bloorview Kids Rehab, The Centre for Addiction and Mental Health, The Hospital for Sick Children, Mount Sinai Hospital, St. Michael's Hospital, Sunnybrook Health Science Centre, Toronto Rehab Institute, University Health Network and Women’s College Hospital.

Creation of the CIHR, as well as establishment of federal funding programs including the Canada Foundation for Innovation, Canada Research Chairs, and Genome Canada; and at the provincial level, establishment of the Ontario Research Fund and the Early Researcher Awards over the past 8 years have dramatically improved the research climate in Canada and Ontario (see Figure 1). The health research community in Toronto has benefited tremendously from infrastructure and salary award funding from these initiatives. The recent “flat-lining” of the CIHR operating budget is a worrisome development. What we need is balanced and stable funding commitments (operating, infrastructure and career awards) at both provincial and federal levels to fund the full costs of research. We will advocate for this once again over the coming year.

Some Highlights of 2007 - 2008

• CIHR New Investigator Awards

Mona Loutfy Department of Medicine Cynthia Ménard Department of Radiation Oncology John Rubinstein Department of Biochemistry Jeffrey Siewerdsen Department of Medical Biophysics Catriona Steele Department of Speech-Language Pathology Halla Thorsteinsdóttir Dalla Lana School of Public Health Qinghua Wang Department of Physiology


V

• New Canada Research Chairs

Tier 1

Stuart Foster Department of Medical Biophysics Rohan Ganguli Department of Psychiatry Richard Horner Department of Medicine Andras Nagy Department of Molecular Genetics Tier 2 Dina Brooks Department of Physical Therapy Brian Ciruna Department of Molecular Genetics Anthony Gramolini Department of Physiology Thomas Kislinger Department of Medical Biophysics Jeffrey Meyer Department of Psychiatry Avery Nathens Department of Surgery Laurence Pelletier Department of Molecular Genetics Kaveh Shojania Department of Medicine

Renewed Canada Research Chairs

Tier 1 Patricia Brubaker Department of Physiology Richard Collins Department of Molecular Genetics Mark Henkleman Department of Medical Biophysics David Jenkins Department of Nutritional Sciences Lewis Kay Department of Molecular Genetics Martin Post Department of Paediatrics Brian Robinson Department of Biochemistry Philip Sherman Department of Paediatrics Elise Stanley Department of Physiology Tier 2 Peter Cheung Department of Medical Biophysics Scott Heximer Department of Physiology Meridith Irwin Department of Paediatrics Wendy Lou Dalla Lana School of Public Health Beverly Orser Department of Anesthesia Andrew Paterson Dalla Lana School of Public Health Peter Roy Department of Molecular Genetics Ahmed El-Sohemy Department of Nutritional Sciences


VI

• MRI Early Researcher Awards


In 2007/08, the following were recipients of this award:

David Fisman Department of Health Policy Management & Evaluation France Gagnon Dalla Lana School of Public Health Anne-Claude Gingras Department of Molecular Genetics Stephen Girardin Department of Laboratory Medicine & Pathobiology Bernard Le Foll Department of Family and Community Medicine Howard Leong-Poi Department of Medicine Angus McQuibban Department of Biochemistry Robert Nam Department of Surgery Kumaraswamy Nanthakumar Department of Medicine John Parkinson Department of Biochemistry


Peter N. Lewis, Ph.D. Vice Dean, Research and International Relations March 31, 2009


VII

SYNOPSIS OF RESEARCH ACTIVITIES 2007 – 2008 The Synopsis of Research Activities in the Faculty of Medicine is published annually by the Faculty Research Office. This,the 22nd edition, which covers the period from April 1, 2007 to March 31, 2008. It presents data and analysis of direct research funding and awards received by faculty members in the Faculty of Medicine for this period. These include operating grants, equipment and maintenance grants, and personnel awards to principal investigators and trainees (graduate students, postdoctoral and clinical fellows), and other research related special grants. Data for the previous four years are presented for comparison. In addition, funding received (as opposed to the total project award) during this period from the Canada Foundation for Innovation (CFI) and from the Ontario Innovation Trust (OIT) or ORF are reported in a separate category. Overhead received and indirect costs such as building maintenance, library and computing services, administrative services, faculty salaries, and basic equipment cost and maintenance are not included. Funding received is segregated by departments and by geographic locations: on campus or in the affiliated hospitals. Guidelines defining research funding and its assignment are described in the Terms of Reference on page XIII. The Faculty Research Office works closely with all Faculty departments, the affiliated hospitals and hospital research institutes to ensure the data reported are as complete and accurate as possible.

INTRODUCTION The Faculty of Medicine at the University of Toronto is the largest medical faculty in Canada and ranks among the top in North America. Currently it admits 224 students to its first year of a 4-year undergraduate medical program. At the post-graduate level, the Faculty offers 75 specialty training programs leading to certification by the Royal College of Physicians and Surgeons of Canada, or by the College of Family Physicians of Canada. In addition to its primary responsibility in medical education, the Faculty participates heavily in the education of undergraduates in the Faculty of Arts and Science and in other health science faculties. To complete its educational role, members of the Faculty actively supervise a large number of graduate students enrolled in M.Sc. and Ph.D. programs, and organize and teach graduate courses. There are 26 departments in the Faculty including 9 departments in basic science (including the Institute of Biomaterials and Biomedical Engineering), 15 in clinical science (including Physical Therapy, Occupational Therapy and Speech-Language Pathology) and two in community health. In addition, there are 22 extra-departmental units (EDUs) organized as either a Centre, Division, Institute, Group, Unit, or Program. These units are inter-departmental in their structure and engage in multidisciplinary research and education. The Faculty has more than 5,000 faculty members holding a range of academic positions that are fully or partly salaried on University budget, or are non-salaried. The scope of research activity in the Faculty of Medicine is very broad, ranging from basic science, clinical investigation to community health and the rehabilitation sciences. There is a


VIII

research continuum from the curiosity-driven to the applied. At one end are studies at the molecular and gene level to create fundamental knowledge crucial to our understanding of the normal and the disease biological process, leading to advancements in diagnosis, more effective prevention and treatment of disease. At the other end are research activities on the promotion of health and wellness, the improvement of rehabilitation, the prevention of disability and the development of policy on health and health administration. The Synopsis measures this large research enterprise in terms of its annual research revenues.

RESEARCH FUNDING: 2007 – 2008 Researchers in the Faculty of Medicine receive research funding from national, provincial and foreign funding agencies. These include the Canadian Institutes for Health Research (CIHR), Natural Sciences and Engineering Research Council (NSERC), Social Sciences and Humanities Research Council (SSHRC), Health Canada (HLTH CAN), and the Ontario Ministry of Health (MOH), and disease-oriented agencies such as the National Cancer Institute of Canada (NCIC), the Heart and Stroke Foundation of Ontario/Canada (HSFO/C), the National Institutes of Health, the Howard Hughes Medical Institute of the United States, and the US Department of Defense (Cancer Programs). In 2007/08, the Faculty received a total of $592 million in research funds from all sources (Table 1), an increase of only 1% from the previous year of $586 million. This represents a rolling average growth of about -1% annually (Table 2B). Research grants accounted for about $501 million of this total, with personnel awards accounting for the remaining $65 million (Table 6). All sectors increased over the past three years (Table 2B). CIHR continued to be the single major source of funding accounting for about $145 million of the total, an increase of 1% from $144 million in the previous year. Other major single sources of funding were NCIC ($19 million) and the Ontario Ministry of Health ($19 million), with slight decreases and increases respectively from the previous year. Funding from Health Canada decreased dramatically to $1.6 million from $7.4 million. Funding from the very diverse category of other sources (see pp 84..) which includes disease-oriented agencies and specific institutional awards increased by 4% to $314 million. Funding from industry increased by 7% to $48 million. Tables 2 and 3 show the "on campus" and "affiliated teaching hospital" geographical assignment of total research revenue. Assignment to hospital sites was about $438 million, accounting for 77 % of the total. Table 4 presents an analysis of the geographical distribution of grants and awards from the various funding agencies. During this period, investigators located in the affiliated teaching hospitals and on campus received $108 million and $37 million respectively from CIHR. Thus as a group, researchers located on campus maintained their share of about 26% of the total CIHR funding. Funding from sources identified as "Other" to campus-based investigators increased by $3 million to about $73 million, whereas there was an increase of about $7 million to hospital-based researchers to $239 million.


IX

GOVERNMENT RESEARCH INFRASTRUCTURE PROGRAMS Canada Foundation for Innovation (CFI) began its infrastructure funding programs during 1999. At time of writing, CFI has awarded a total of 100 institutional projects from the Faculty and its affiliated hospitals. These projects were based on the following five research platforms identified by the Faculty in consultation with the departments and hospital research institutes:


About $12 million has been received from CFI and OIT, and from Genome Canada for 2007/ 08. This does not include CFI New Opportunities awards, which are included in the total research funding.

COMPARISON TO PREVIOUS YEARS Table 2A shows the annual research funding in current dollars by department from 2003 to 2008. The annual changes are analyzed as an average over a 3-year period. Table 2B shows the same data in 2003 constant dollars. All sectors have continued to grow. Overall, total research funding in current dollars over the 5-year period increased by $127M, or $83 M in constant dollars since 2003. Figure 1 shows that in the 16-year period beginning 1987, research revenue of the Faculty initially followed a linear rate of growth at an average of of 11%/year over 13 years in spite of a slight hiatus from 1993 to 1995, a period of federal budget constraint on research. In 2000 the rate of growth increased dramatically and is almost linear rate of growth at an average of 15%/year over 8 years in current dollars or 3.6%/year in constant dollars. Table 5 presents the research funding by source in this and the previous seven years. Funding from Canadian federal sources showed an increase from $105 M in 2000/2001 to nearly $228 M in 2007/08, for 38% of the Faculty total research revenue. Research revenue from provincial sources has remained constant at 14% from 2000/2001. Funding from not-for-profit organizations accounts for about 20% of the total. Industrial funding increased to 8% of the total research revenue from 7% last year. (Figure 1 and Table 5).

RESEARCH AWARDS The total number of research grants in 2007/08 was 4,121, up 2% from the previous year of 4,030 (Table 6). The number of research personnel awards to principal investigators has decreased from 176 to 175. 12 Canada Research Chairs were awarded and 17 renewed in 2007/08.


X


Research Fellows Postdoctoral fellows and clinical research fellows are major contributors to the research enterprise of the Faculty. Tables 7 and 8 summarize the distribution of postdoctoral fellows and clinical research fellows in the Faculty. The number of postdoctoral and clinical research fellows has increased by 9% from 2006/07 to 1199.

Graduate Student Funding – data for 2007/08 In 2007/08 the total graduate student funding (awards and stipends) was $44.5 M (38.7 M), and of this, $25 M (22.7M) were awards, while $19.5 M (15.9 M) were stipends, as shown in Table 10. The award and stipend distribution by the Graduate unit is given in Table 11. The breakdown by administrative site is provided in Table 12. The total funding supports about 2000 graduate students. Numbers in parentheses are from 2006/07.


XI

Research Space The total campus research space of the Faculty of Medicine currently is 30,377 sq m (Table 9). On-campus research and research-support space in the Faculty has changed dramatically over the past few years. For more than thirty-five years, the Banting Institute, Best Institute, FitzGerald Building, Medical Sciences Building, McMurrich Building, Tanz Neuroscience Building, Gage Research Institute, together with buildings at 1 Spadina, 256 McCaul Street, and 82 and 88 College Street have housed the Faculty of Medicine. This changed eight years ago with the purchase and subsequent renovation of a 10-storey building (6,700 nasm) at 500 University Avenue. This building now houses the Departments of Physical Therapy, Occupational Science and Occupational Therapy, Speech-Language Pathology, as well as the Offices of the Vice Deans of Continuing Education & Professional Development and Postgraduate Medicine. The construction of the $96M Donnelly Centre for Cellular and Biomolecular Research (CCBR) was completed in 2005. The CCBR (10,000 nasm) has 30 faculty and ultimately will house 35 principal investigators and more than 500 research staff. Additionally extensive renovations were made in 2004/05 to the Banting Institute to house the Structural Genomics Consortium, a $60M joint project with the UK. Finally, four years ago the University purchased the former Board of Education building (155 College Street), which has been extensively renovated and now houses three Faculty departments/schools: Dalla Lana School of Public Health; Health Policy, Management and Evaluation; and Family and Community Medicine. The McMurrich Building, previously home to PHS and HPME, has been returned to the University for other purposes. In the coming year, in connection with the just announced CFI competition, the MSB will be renovated to provide improved research, teaching and support space.


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appointment.










an RIS ‘by-Location’ Report download (data snapshot) initiated at 1236 hrs of January 28, 2009.





AwardsBASICBBDMR 42,146 6,465 199 840 0 0 99 0 3,070 31,475 136Biochemistry 16,358 5,433 540 1,283 0 0 255 0 464 8,383 227Biomat & Biomed Eng 2,330 992 119 0 0 398 187 0 57 576 33Immunology 14,319 3,387 119 494 0 0 223 0 1,231 8,865 145Medical Biophysics 54,875 7,529 482 5,368 0 0 445 0 2,986 38,065 466Medical Genetics & Microbiology 60,635 15,777 492 4,117 0 500 69 0 2,484 37,195 537Nutritional Sciences 5,556 1,690 735 0 0 0 0 0 1,208 1,923 139Pharmacology 4,631 1,461 78 118 0 0 181 0 467 2,326 89Physiology 14,575 6,031 521 0 0 0 1,016 0 340 6,667 332


SUB-TOTAL 38,997 11,754 162 0 284 6,006 75 402 690 19,624 523CLINICALAnesthesia 5,348 1,425 27 0 0 0 0 0 1,093 2,803 109Family & Community Medicine 7,014 656 0 0 855 3,607 0 0 600 1,296 52Lab. Medicine & Pathobiology 28,450 6,788 652 1,894 0 443 1,996 0 2,084 14,593 419Medical Imaging 6,341 634 40 72 0 860 114 0 664 3,957 63Medicine 115,248 30,912 167 1,870 449 1,168 6,003 48 16,863 57,767 1,521Obstetrics & Gynaecology 8,148 4,984 73 0 0 119 0 0 739 2,233 93Occupational Therapy 1,958 206 56 0 0 61 15 66 0 1,555 212Ophthalmology And Vision Sci 4,643 713 0 249 0 1,234 0 0 528 1,919 72Otolaryngology 585 197 0 0 0 0 0 0 33 355 15Paediatrics 46,841 20,029 71 877 76 304 1,092 0 2,477 21,915 495Physical Therapy 2,728 527 27 0 0 440 253 1 0 1,480 244Psychiatry 22,268 8,317 66 133 0 368 140 688 2,135 10,421 378Radiation Oncology 13,406 962 26 609 0 60 0 0 1,898 9,851 92Speech-Language Pathology 1,496 339 30 0 0 45 89 90 105 798 166Surgery 35,144 6,175 156 1,265 0 284 1,662 0 6,125 19,477 500

SUB-TOTAL 299,618 82,864 1,391 6,969 1,380 8,993 11,364 893 35,344 150,420 4,431Other 1 12,881 1,749 23 0 0 3,005 0 1 0 8,104 336


GRAND TOTAL 4 591,565 (x $1000) 7,431






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DEPARTMENT Hospital Campus Hospital Campus Hospital Campus Hospital Campus Hospital CampusBASICBBDMR 3,142 8,539 2,482 44,760 1,561 21,123 2,845 21,602 2,758 39,388Biochemistry 6,035 3,551 16,274 4,479 9,321 4,904 8,503 6,420 10,663 5,695Biomat & Biomed Eng 1,664 452 987 1,170 1,663 914 1,227 1,107 1,013 1,316Immunology 5,870 1,141 9,154 1,591 9,929 3,429 11,218 2,529 11,777 2,542Medical Biophysics 46,157 682 72,793 1,629 64,082 1,121 65,944 3,105 53,374 1,501Medical Genetics & Microbiology 30,314 9,729 37,154 8,555 49,934 7,999 53,848 11,017 48,593 12,042Nutritional Sciences 2,034 2,520 1,607 3,410 1,634 3,184 1,987 4,744 1,588 3,968Pharmacology 1,268 2,657 1,339 2,717 1,079 4,923 1,665 6,104 1,801 2,830Physiology 4,763 6,452 4,714 6,561 5,567 7,415 6,228 9,294 7,072 7,503


SUB-TOTAL 12,633 13,039 15,735 16,758 18,980 13,776 18,236 15,279 24,233 14,764CLINICALAnesthesia 3,481 393 3,561 700 3,343 472 3,450 524 4,846 502Family & Community Medicine 1,781 204 4,010 785 4,722 510 8,033 691 6,702 313Lab. Medicine & Pathobiology 20,404 6,675 17,707 7,691 17,483 6,715 19,357 6,675 22,095 6,355Medical Imaging 3,174 5 7,325 15 9,514 179 9,124 507 6,073 268Medicine 71,622 10,798 88,744 16,133 88,088 15,514 86,565 21,270 97,690 17,558Obstetrics & Gynaecology 5,820 0 7,123 1 8,056 26 7,848 129 8,067 81Occupational Therapy 432 891 604 813 689 976 1,176 1,613 792 1,166Ophthalmology And Vision Sci 3,087 1,106 3,448 1,090 3,593 1,324 3,859 1,668 3,294 1,349Otolaryngology 487 0 426 21 445 14 888 51 543 42Paediatrics 20,531 33 20,562 201 27,665 190 40,616 523 46,433 408Physical Therapy 991 618 1,321 767 1,042 1,484 1,318 1,311 1,483 1,245Psychiatry 20,394 486 23,722 1,437 21,666 1,019 23,264 1,950 21,657 611Radiation Oncology 7,607 5 7,269 28 8,154 75 11,590 254 13,210 195Speech-Language Pathology 46 706 433 1,066 299 1,351 267 1,189 328 1,168Surgery 23,932 807 24,686 885 37,382 1,560 32,540 1,801 33,668 1,476

SUB-TOTAL 183,789 22,727 210,941 31,633 232,141 31,409 249,895 40,156 266,881 32,737Other 1 21,932 12,556 9,868 1,786 12,063 2,331 6,562 5,014 7,920 4,961

TOTAL 319,601 84,045 383,048 125,049 407,954 102,528 428,158 126,371 437,673 129,247CFI/OIT 2 41,551 18,913 19,187 18,141 18,462 4,900 28,198 2,001 10,495 1,953Indirect Costs 3 11,805 1,278 12,946 1,621 10,559 1,638






FY 2003-04 FY 2004-05 FY 2005-06 FY 2006-07 FY 2007-08


591,564599,296

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Department All Locations Campus Baycrest Bloorview CAMH HSC MSH SMH SHSC TRI UHN WCH OtherBASICBBDMR 42,146 39,388 0 0 0 1,241 3 0 0 0 1,514 0 0Biochemistry 16,358 5,695 0 0 0 9,390 32 0 0 0 1,241 0 0Biomat & Biomed Eng 2,330 1,316 0 162 0 0 0 0 0 371 480 0 0Immunology 14,319 2,542 0 0 0 6,278 678 0 2,780 0 2,040 0 0Medical Biophysics 54,875 1,501 353 0 0 3,129 1,143 0 15,913 0 32,836 0 0Medical Genetics & Microbiology 60,635 12,042 0 0 0 22,046 22,550 0 0 0 3,997 0 0Nutritional Sciences 5,556 3,968 0 0 0 108 58 1,421 0 0 0 0 0Pharmacology 4,631 2,830 0 0 501 38 0 650 612 0 0 0 0Physiology 14,575 7,503 0 0 0 4,057 0 478 0 0 2,537 0 0

SUB-TOTAL 215,424 76,784 353 162 501 46,287 24,465 2,549 19,305 371 44,645 0 0COMMUNITY HEALTHHealth Policy, Mgmt & Eval 7,644 5,662 0 0 413 517 0 436 287 25 303 0 0Public Health Sciences 31,353 9,102 0 0 6,806 2,517 1,778 5,643 701 205 1,255 1,604 1,743

SUB-TOTAL 38,997 14,764 0 0 7,219 3,034 1,778 6,080 988 230 1,559 1,604 1,743CLINICALAnesthesia 5,348 502 0 0 0 753 262 1,128 464 0 2,200 40 0Family & Community Medicine 7,014 313 0 0 4,301 16 19 1,127 222 0 428 101 487Lab. Medicine & Pathobiology 28,450 6,355 0 0 0 3,867 6,067 1,040 4,025 0 7,080 10 5Medical Imaging 6,341 268 0 0 0 1,150 128 32 4,625 0 137 0 0Medicine 115,248 17,558 2,207 0 288 295 12,521 24,399 11,958 1,084 42,932 1,698 307Obstetrics & Gynaecology 8,148 81 0 0 0 37 4,961 278 0 0 454 2,336 0Occupational Therapy 1,958 1,166 63 37 0 0 0 207 0 485 0 0 0Ophthalmology And Vision Sci 4,643 1,349 0 0 0 580 5 801 0 0 1,908 0 0Otolaryngology 585 42 0 0 0 388 75 0 80 0 0 0 0Paediatrics 46,841 408 0 137 0 33,634 180 60 169 38 11,600 616 0Physical Therapy 2,728 1,245 147 54 0 13 0 11 19 679 268 249 43Psychiatry 22,268 611 685 0 12,735 2,015 275 1,023 465 289 3,766 234 171Radiation Oncology 13,406 195 0 0 0 0 43 0 1,854 0 11,091 222 0Speech-Language Pathology 1,496 1,168 0 21 0 0 0 0 0 262 45 0 0Surgery 35,144 1,476 0 0 0 7,647 2,250 3,072 3,929 3,474 13,274 23 0

SUB-TOTAL 299,619 32,736 3,101 249 17,324 50,395 26,786 33,179 27,810 6,310 95,184 5,530 1,013Other 12,881 4,961 0 0 356 1,069 49 30 2,944 3,020 452 0 0CFI/OIT 12,448 1,953 0 0 2,200 3,196 5,099 0 0 0 0 0 0Indirect Costs 1 12,196 1,638 0 171 1,235 315 4,050 201 932 1,272 2,383 0 0

GRAND TOTAL 591,564 132,836 3,454 412 27,600 103,980 58,177 41,838 51,048 9,931 141,840 7,134 2,7561 Excludes a total of $18,440,070 from the Federal Indirect Costs Program awarded to affiliate hospitals.




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# of Awards

Baycrest Centre for Geriatric Care 3,454 1,699 26 0 0 0 1,085 0 81 563 36Bloorview Kid's Rehab 412 0 25 0 0 0 0 0 37 349 17Centre for Addiction and Mental Health 25,400 6,126 48 0 40 4,206 89 365 2,552 11,973 256Hospital for Sick Children 100,784 23,300 562 3,726 76 561 2,467 0 6,289 63,803 1,055Mount Sinai Hospital 52,957 17,515 394 3,556 0 74 496 0 5,165 25,757 588St. Michael's Hospital 42,109 7,652 224 4 604 3,562 1,240 48 7,289 21,487 699SHSC

Sunnybrook site 51,023 8,614 229 2,965 0 1,722 2,376 0 3,897 31,219 372 Orthopaedic & Arthritic site 25 0 0 0 0 0 0 0 0 25 2Toronto Rehabilitation Institute 9,931 960 53 0 0 3,514 187 0 145 5,072 101University Health Network 141,840 37,445 369 6,016 421 1,109 4,177 0 16,542 75,761 1,272Women's College Hospital 7,134 4,030 0 0 0 385 0 0 166 2,553 57Other Hospitals 1 2,223 294 0 0 477 70 0 0 0 1,382 34



GRAND TOTAL 591,564 (x $1000) 7,431

1 Research at non-affilitaed hospitals.2 Research at other locations other than UofT Campus and other hospitals.3 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Health Sciences Centre, University of Toronto and the University Health Network.




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DEPARTMENT FY 2003-04 FY 2004-05 FY 2005-06 FY 2006-07 FY 2007-08 2003-2006 2004-2007 2005-2008BASICAnatomy and Cell Biology 1 N/A N/A N/A N/A N/A N/A N/A N/ABBDMR 11,681 47,242 22,684 24,446 42,146 126.2 -22.1 40.1Biochemistry 9,585 20,754 14,224 14,923 16,358 42.5 -13.3 7.3Biomat & Biomed Eng 2,116 2,157 2,578 2,334 2,330 10.7 5.0 -4.8Immunology 7,011 10,745 13,357 13,747 14,319 38.8 13.6 3.5Medical Biophysics 46,839 74,422 65,203 69,049 54,875 23.3 -3.2 -7.3Medical Genetics & Microbiology 40,043 45,709 57,933 64,865 60,635 20.4 19.4 2.7Nutritional Sciences 4,554 5,016 4,819 6,731 5,556 3.1 17.9 11.1Pharmacology 3,925 4,056 6,003 7,769 4,631 25.7 38.7 -5.5Physiology 11,215 11,275 12,982 15,521 14,575 7.8 17.4 6.7

SUB-TOTAL 136,969 221,374 199,783 219,387 215,424 25.9 0.0 4.0COMMUNITY HEALTHHealth Policy, Mgmt & Eval 6,844 8,478 7,738 6,375 7,644 7.6 -13.2 1.1Public Health Sciences 18,827 24,014 25,018 27,141 31,353 15.9 6.3 12.0

SUB-TOTAL 25,671 32,493 32,756 33,516 38,997 13.7 -6.9 13.1CLINICALAnesthesia 3,874 4,262 3,814 3,974 5,348 -0.2 -3.2 19.4Family & Community Medicine 1,985 4,796 5,232 8,724 7,014 75.3 37.9 23.6Lab. Medicine & Pathobiology 27,078 25,398 24,198 26,033 28,450 -5.5 1.4 8.4Medical Imaging 3,179 7,340 9,694 9,631 6,341 81.5 15.7 -17.4Medicine 82,421 104,876 103,601 107,835 115,248 13.0 1.4 5.5Obstetrics & Gynaecology 5,820 7,125 8,083 7,977 8,148 17.9 6.1 0.4Occupational Therapy 1,323 1,418 1,665 2,789 1,958 12.3 42.5 18.9Ophthalmology And Vision Sci 4,193 4,537 4,917 5,527 4,643 8.3 10.4 -1.8Otolaryngology 487 447 459 939 585 -2.7 53.6 33.3Paediatrics 20,563 20,763 27,855 41,139 46,841 17.6 40.9 30.8Physical Therapy 1,609 2,089 2,527 2,629 2,728 25.4 12.5 3.9Psychiatry 20,880 25,159 22,685 25,215 22,268 5.3 0.7 -0.3Radiation Oncology 7,612 7,297 8,229 11,843 13,406 4.3 28.3 28.6Speech-Language Pathology 752 1,500 1,650 1,457 1,496 54.7 -0.9 -4.5Surgery 24,738 25,571 38,942 34,342 35,144 27.8 20.2 -4.7

SUB-TOTAL 206,515 242,577 263,550 290,053 299,619 13.1 9.4 6.7Other 2 34,489 11,654 14,394 11,576 12,881 -21.3 2.0 -4.2

TOTAL 403,644 508,098 510,483 554,531 566,920 13.2 4.5 5.4CFI/OIT 3 60,464 37,328 23,361 30,198 12,448 -37.8 -4.1 -14.8Indirect Costs 4 1,635 12,196

GRAND TOTAL 464,107 545,426 533,844 586,365 591,564 7.7 3.9 5.4

1 Defunct Depertment of Anatomy and Cell Biology in 2001/022 Includes global research budget of the Institute for Clinical Evaluative Sciences, Structural Genomics Consortium, SARS Laboratory, UofT Equipment maintenance grants, clinical trial grants at the Sunnybrook Hospital/University of Toronto Clinic, ORDCF grants, Ontario Genomics Institute grants, undergraduate summer studentship awards, graduate studentship awards for independent study and Health Communication Research Laboratory in the Faculty of Medicine.3 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Health Sciences Centre, University of Toronto and the University Health Network.




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FY 2003-04 FY 2004-05 FY 2005-06 FY 2006-07 FY 2007-08Index values: 1.00 1.02 1.04 1.06 1.08 2003-2006 2004-2007 2005-2008

DEPARTMENTBASICAnatomy and Cell Biology 1 N/A N/A N/A N/A N/A N/A N/A N/ABBDMR 11,681 46,315 21,812 23,063 39,024 121.8 -23.6 37.5Biochemistry 9,585 20,347 13,677 14,079 15,146 39.7 -14.9 5.3Biomat & Biomed Eng 2,116 2,114 2,478 2,202 2,157 8.6 3.0 -6.6Immunology 7,011 10,534 12,844 12,969 13,258 36.1 11.5 1.6Medical Biophysics 46,839 72,963 62,695 65,141 50,810 20.9 -5.1 -9.0Medical Genetics & Microbiology 40,043 44,812 55,705 61,193 56,144 18.1 17.1 0.8Nutritional Sciences 4,554 4,918 4,633 6,350 5,144 1.1 15.6 9.0Pharmacology 3,925 3,977 5,772 7,330 4,288 23.2 36.1 -7.3Physiology 11,215 11,054 12,483 14,643 13,495 5.7 15.1 4.7

SUB-TOTAL 136,969 217,034 192,099 206,970 199,466 23.5 -1.9 2.1COMMUNITY HEALTHHealth Policy, Mgmt & Eval 6,844 8,312 7,440 6,014 7,078 5.5 -14.8 -0.7Public Health Sciences 18,827 23,543 24,056 25,605 29,031 13.6 4.3 9.9

SUB-TOTAL 25,671 31,855 31,496 31,619 36,109 11.5 -10.5 9.2CLINICALAnesthesia 3,874 4,178 3,668 3,749 4,952 -2.2 -5.0 17.2Family & Community Medicine 1,985 4,702 5,030 8,230 6,495 71.9 35.3 21.3Lab. Medicine & Pathobiology 27,078 24,900 23,267 24,559 26,343 -7.3 -0.5 6.4Medical Imaging 3,179 7,196 9,321 9,086 5,871 78.0 13.5 -19.0Medicine 82,421 102,820 99,617 101,731 106,711 10.8 -0.5 3.5Obstetrics & Gynaecology 5,820 6,985 7,772 7,526 7,544 15.6 4.0 -1.5Occupational Therapy 1,323 1,390 1,601 2,631 1,813 10.1 39.8 16.6Ophthalmology And Vision Sci 4,193 4,448 4,728 5,214 4,299 6.2 8.3 -3.6Otolaryngology 487 438 442 886 541 -4.6 50.6 30.8Paediatrics 20,563 20,356 26,784 38,810 43,372 15.3 38.2 28.3Physical Therapy 1,609 2,048 2,429 2,480 2,526 23.0 10.4 2.0Psychiatry 20,880 24,666 21,813 23,787 20,619 3.3 -1.3 -2.1Radiation Oncology 7,612 7,154 7,912 11,173 12,413 2.3 25.9 26.2Speech-Language Pathology 752 1,470 1,586 1,374 1,386 51.7 -2.7 -6.3Surgery 24,738 25,070 37,444 32,398 32,541 25.3 17.9 -6.5

SUB-TOTAL 206,514 237,821 253,414 273,634 277,426 10.9 7.3 4.7Other 2 34,489 11,426 13,840 10,921 11,927 -22.9 0.0 -5.9







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Department All Locations Campus Baycrest Bloorview CAMH HSC MSH SMH SHSC TRI UHN WCH OtherBASICBBDMR 29,759 27,371 0 0 0 1,608 1 0 0 0 779 0 0Biochemistry 15,168 5,673 0 0 0 8,069 782 0 0 0 642 0 2Biomat & Biomed Eng 2,414 1,112 0 360 0 0 0 0 0 288 653 0 0Immunology 13,808 2,833 0 0 0 4,977 686 0 2,449 0 2,847 17 0Medical Biophysics 63,042 1,909 230 0 0 2,038 1,259 0 21,233 0 36,374 0 0Medical Genetics & Microbiology 61,144 10,353 0 0 3 26,135 21,733 0 0 0 2,921 0 0Nutritional Sciences 5,702 3,966 91 0 0 62 248 1,335 0 0 0 0 0Pharmacology 6,134 4,619 0 0 526 156 0 492 336 0 6 0 0Physiology 14,359 8,071 0 0 0 3,461 8 365 0 0 2,435 0 20SUB-TOTAL 211,530 65,907 321 360 529 46,506 24,717 2,192 24,018 288 46,657 17 22COMMUNITY HEALTHHealth Policy, Mgmt & Eval 7,252 5,569 5 0 335 369 0 210 434 43 287 0 0Public Health Sciences 27,837 9,038 0 5 5,976 2,105 1,980 3,706 581 78 1,371 1,537 1,461SUB-TOTAL 35,089 14,607 5 5 6,311 2,474 1,980 3,916 1,015 121 1,658 1,537 1,461CLINICALAnesthesia 4,379 499 0 0 0 738 211 1,079 365 0 1,448 39 0Family & Community Medicine 6,990 504 0 0 4,318 8 321 863 232 0 454 34 256Lab. Medicine & Pathobiology 26,227 6,582 0 0 0 3,782 5,839 913 2,866 0 6,241 3 2Medical Imaging 8,555 318 0 0 0 712 215 11 7,100 0 199 0 0Medicine 108,895 18,114 2,136 64 148 215 10,778 22,634 12,716 873 39,795 1,154 267Obstetrics & Gynaecology 8,069 79 0 0 0 32 4,911 220 528 0 214 2,084 0Occupational Therapy 2,137 1,252 21 84 0 0 0 330 0 388 21 0 42Ophthalmology And Vision Sci 5,029 1,447 0 0 0 891 2 792 0 0 1,898 0 0Otolaryngology 661 36 0 0 0 369 25 37 195 0 0 0 0Paediatrics 38,612 374 0 110 0 29,703 103 37 234 70 7,410 560 11Physical Therapy 2,628 1,347 136 33 0 4 0 6 86 548 240 201 28Psychiatry 23,389 1,193 785 2 14,013 1,574 149 954 641 198 3,587 135 159Radiation Oncology 11,159 175 0 0 0 0 14 0 1,568 0 9,110 293 0Speech-Language Pathology 1,534 1,236 0 56 0 0 0 0 77 143 23 0 0Surgery 36,143 1,613 0 0 18 7,422 2,632 3,319 3,805 5,803 11,454 76 0SUB-TOTAL 284,407 34,769 3,078 349 18,497 45,450 25,200 31,195 30,413 8,023 82,094 4,579 765Other 12,950 4,102 0 0 166 1,319 1,015 94 3,020 3,007 228 0 0GRAND TOTAL 543,976 119,385 3,404 714 25,503 95,749 52,912 37,397 58,466 11,439 130,637 6,133 2,248




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Department All Locations Campus Baycrest Bloorview CAMH HSC MSH SMH SHSC TRI UHN WCH OtherBASICBBDMR 6,972 6,848 0 0 0 124 0 0 0 0 0 0 0Biochemistry 5,810 2,183 0 0 0 3,206 213 0 0 0 206 0 2Biomat & Biomed Eng 952 750 0 124 0 0 0 0 0 54 24 0 0Immunology 4,013 959 0 0 0 594 291 0 1,051 0 1,119 0 0Medical Biophysics 8,227 563 56 0 0 352 41 0 2,080 0 5,109 27 0Medical Genetics & Microbiology 15,580 4,057 0 0 0 4,236 6,969 0 14 0 305 0 0Nutritional Sciences 2,467 1,377 128 0 0 37 229 697 0 0 0 0 0Pharmacology 1,617 1,550 0 0 0 0 0 54 9 0 4 0 0Physiology 6,181 4,000 0 0 0 942 0 79 0 0 1,160 0 0SUB-TOTAL 51,819 22,287 184 124 0 9,491 7,743 830 3,154 54 7,927 27 2COMMUNITY HEALTHHealth Policy, Mgmt & Eval 2,620 1,845 10 0 0 133 0 0 271 0 333 15 13Public Health Sciences 8,301 4,080 0 0 839 546 1,560 157 339 15 126 171 466SUB-TOTAL 10,921 5,925 10 0 839 679 1,560 157 610 15 459 186 479CLINICALAnesthesia 1,333 264 0 0 0 530 0 222 176 0 111 30 0Family & Community Medicine 813 215 0 0 169 0 111 159 159 0 0 0 0Lab. Medicine & Pathobiology 8,127 2,234 0 0 0 1,451 1,178 102 1,223 0 1,938 0 0Medical Imaging 509 67 0 0 0 154 0 0 208 0 79 0 0Medicine 26,175 5,038 1,193 0 20 79 2,646 3,960 3,448 47 9,252 410 80Obstetrics & Gynaecology 5,424 5 0 0 0 0 2,706 0 528 0 0 2,185 0Occupational Therapy 356 206 0 14 0 0 0 58 0 78 0 0 0Ophthalmology And Vision Sci 845 0 0 0 0 160 0 30 0 0 655 0 0Otolaryngology 230 15 0 0 0 149 0 0 66 0 0 0 0Paediatrics 11,023 35 0 0 0 6,893 0 0 169 57 3,533 335 0Physical Therapy 608 261 0 0 0 0 22 0 67 150 108 0 0Psychiatry 8,358 1,030 323 0 4,640 618 83 80 130 45 1,281 69 59Radiation Oncology 822 15 0 0 0 0 0 0 91 0 716 0 0Speech-Language Pathology 384 315 0 0 0 0 0 0 0 69 0 0 0Surgery 7,235 238 0 0 33 1,554 1,183 435 935 168 2,688 0 0SUB-TOTAL 72,242 9,938 1,516 14 4,862 11,588 7,929 5,046 7,200 614 20,361 3,029 139Other hospitals 1,740 466 0 0 47 1,027 31 84 51 0 35 0 0GRAND TOTAL 136,722 38,616 1,710 138 5,748 22,785 17,263 6,117 11,015 683 28,782 3,242 620




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HOSPITAL FY 2003-04 FY 2004-05 FY 2005-06 FY 2006-07 FY 2007-08 2003-2006 2004-2007 2005-2008Baycrest Centre for Geriatric Care 3,050 2,824 3,177 3,583 3,454 2.5 12.6 4.6Bloorview Kid's Rehab 1,438 656 1,044 685 412 2.4 12.4 -37.1Centre for Addiction and Mental Health 19,961 24,140 22,255 28,851 25,400 6.6 10.9 8.8Hospital for Sick Children 59,445 55,171 85,958 100,498 100,784 24.3 36.4 8.6Mount Sinai Hospital 52,206 62,284 56,945 48,503 52,957 5.4 -11.7 -2.8St. Michael's Hospital 24,640 34,379 35,077 36,826 42,109 20.8 3.5 9.7SHSC Sunnybrook site 44,675 64,826 63,356 60,741 51,023 21.4 -3.2 -10.1 Orthopaedic & Arthritic site 112 0 78 129 25 . 65.2 .Toronto Rehabilitation Institute 1,054 4,637 14,316 10,072 9,931 274.4 89.5 -15.5University Health Network 106,129 120,475 118,179 131,791 141,840 5.8 4.8 9.6Women's College Hospital 6,830 12,604 7,090 4,177 7,134 20.4 -42.4 14.8Other Hospitals 2 3,381 1,660 1,242 2,115 2,223 -38.0 22.6 37.7



GRAND TOTAL 6 467,488 545,426 533,844 586,365 591,564 7.3 3.9 5.4





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HOSPITALBaycrest Centre for Geriatric Care 3,050 2,769 3,055 3,380 3,198 0.5 10.5 2.6Bloorview Kid's Rehab 1,438 643 1,004 646 381 0.4 10.2 -38.3Centre for Addiction and Mental Health 19,961 23,666 21,399 27,218 23,519 4.5 8.8 6.8Hospital for Sick Children 59,445 54,089 82,652 94,809 93,319 21.9 33.8 6.6Mount Sinai Hospital 52,206 61,063 54,755 45,757 49,034 3.3 -13.4 -4.6St. Michael's Hospital 24,640 33,705 33,728 34,741 38,990 18.4 1.5 7.6SHSC Sunnybrook site 44,675 63,554 60,919 57,303 47,243 19.1 -5.0 -11.7 Orthopaedic & Arthritic site 112 0 75 122 23 . 62.1 -9.5Toronto Rehabilitation Institute 1,054 4,546 13,765 9,502 9,195 267.1 85.9 -17.1University Health Network 118,113 113,634 124,331 131,333 3.7 2.8 7.5Women's College Hospital 6,830 12,357 6,817 3,941 6,605 18.0 -43.5 12.7Other Hospitals 2 3,381 1,628 1,194 1,995 2,058 -39.2 20.2 35.1



GRAND TOTAL 467,488 534,732 513,312 553,175 547,745 5.2 1.9 3.4

1 Percentage represents the annual changes in funding averaged over each three year period.2 Non-affiliated hospitals and Institute of Work and Health3 Research at locations other than U of T campus or other affiliated/non-affiliated hospitals.





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SOURCE FY 2000-01 % FY 2001-02 % FY 2002-03 % FY 2003-04 % FY 2004-05 % FY 2005-06 % FY 2006-07 % FY 2007-08 %FEDERAL GOV.Federal Canada 89,970 31.4 109,557 35.8 131,170 37.4 144,361 35.5 186,328 36.7 192,543 37.7 219,249 39.5 210,337 37.1Federal U.S. 14,617 5.1 20,047 6.5 14,727 4.2 19,166 4.7 17,013 3.3 17,448 3.4 22,692 4.1 17,586 3.1Federal Other 14 0.0 #VALUE! . . 0.0 #VALUE! . . . 0 0.0 88 0.0 0 0.0Sub-Total 104,601 36.5 129,603 42.3 145,906 41.6 163,528 40.2 203,341 40.0 209,990 41.1 242,029 43.6 227,923 40.2PROVINCIAL GOV.Provincial Canada 41,071 14.4 45,277 14.8 41,085 11.7 61,892 15.2 93,380 18.4 77,447 15.2 60,836 11.0 76,336 13.5Sub-Total 41,071 14.4 45,277 14.8 41,085 11.7 61,892 15.2 93,380 18.4 77,447 15.2 60,836 11.0 76,336 13.5LOCAL SOURCESLocal 8,441 2.9 10,617 3.5 15,339 4.4 18,640 4.6 26,695 5.3 32,968 6.5 31,929 5.8 40,165 7.1Internal Univ/Hosp 10,424 3.6 10,738 3.5 12,722 3.6 12,550 3.1 13,836 2.7 12,927 2.5 18,936 3.4 14,428 2.5Sub-Total 18,866 6.5 21,355 7.0 28,061 8.0 31,190 7.7 40,531 8.0 45,894 9.0 50,865 9.2 54,593 9.6INDUSTRYCanadian Industry 31,478 11.0 20,815 6.8 22,077 6.3 19,731 4.8 25,219 5.0 22,070 4.3 25,284 4.6 25,762 4.5U.S. Industry 8,555 3.0 7,612 2.5 13,111 3.7 14,515 3.6 10,297 2.0 12,273 2.4 12,965 2.3 15,132 2.7Other Foreign Ind. 1,927 0.7 1,478 0.5 1,138 0.3 11,138 2.7 2,434 0.5 4,130 0.8 4,402 0.8 7,446 1.3Sub-Total 41,960 14.7 29,905 9.8 36,327 10.3 45,384 11.1 37,950 7.5 38,473 7.5 42,651 7.7 48,341 8.5NOT-FOR-PROFITCanadian Charity 43,820 15.3 46,403 15.2 60,666 17.3 65,461 16.1 73,970 14.6 74,207 14.5 84,244 15.2 81,378 14.4Provincial Charity 12,533 4.4 12,665 4.1 15,875 4.5 14,746 3.6 16,792 3.3 17,602 3.4 25,476 4.6 19,674 3.5U.S. Charity 6,145 2.1 7,490 2.4 7,066 2.0 8,449 2.1 8,949 1.8 10,609 2.1 13,602 2.5 14,240 2.5Other Foreign Charity 1,779 0.6 1,925 0.6 1,550 0.4 1,675 0.4 432 0.1 384 0.1 307 0.1 1,416 0.2Sub-Total 64,277 22.4 68,482 22.3 85,157 24.2 90,330 22.2 100,142 19.8 102,801 20.1 123,630 22.4 116,707 20.6OTHEROther Canadian Inst. 2,905 1.0 2,333 0.8 1,935 0.6 1,899 0.5 5,057 1.0 6,627 1.3 6,506 1.2 8,025 1.4U.S. Institutions 2,161 0.8 1,840 0.6 2,337 0.7 1,789 0.4 8,018 1.6 6,717 1.3 6,027 1.1 6,787 1.2Other Foreign Inst. 79 0.0 231 0.1 327 0.1 248 0.1 205 0.0 384 0.1 135 0.0 214 0.0Sub-Total 5,146 1.8 4,404 1.5 4,600 1.4 3,936 1.0 13,281 2.6 13,728 2.7 12,668 2.3 15,026 2.6MISCELLANEOUSVarious Sponsors 10,283 3.6 7,181 2.3 9,769 2.8 10,764 2.6 19,473 3.8 22,142 4.3 20,462 3.7 27,941 4.9Sub-Total 10,283 3.6 7,181 2.3 9,769 2.8 10,764 2.6 19,473 3.8 22,142 4.3 20,462 3.7 27,941 4.9TOTAL 286,203 100 306,208 100 350,905 100 407,024 100 508,098 100 510,476 100 553,141 100 566,866 100CFI/OIT1 60,464 37,328 23,361 30,198 12,448Indirect Costs 2 1,635 12,196GRAND TOTAL 3 286,203 100 306,208 100 350,905 100 467,488 100 545,426 100 533,837 100 584,975 100 591,510 100Fiscal Year values represent THOUSANDS of dollars.1 The CFI and OIT funding represents infrastructure grants from Federal and Provincial sources.

3 2003-04 value excludes $11,804,786; 2004-05 excludes $12,946,032; 2005-06 excludes $15,081,736; 2006-07 excludes $17,922,835; 2007-08 excludes $18,440,070 from the Federal Indirect Costs Program awarded to affiliate hospitals.




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0%

20%

40%

60%

80%

100%19

87

1988

1989

1990

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1992

1993

1994

1995

1996

1997

1998

1999

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2001

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2003

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2007

2008


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Tota

l Fun

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CIHR Contribution


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GRAND TOTAL 4 $591,564,418 7431








13

DEPARTMENTPrimary Appt On Campus Off Campus Cross Appt Tenure Appt Tenure Stream Career Awards Pri Appt with

Res Funds


Pri Appt


BASICBBDMR 24 22 2 2 11 8 8 25 45 17Biochemistry 34 19 15 21 18 1 14 27 97 17Biomat & Biomed Eng 11 8 3 56 4 5 1 12 2 10Immunology 27 6 21 33 3 3 6 24 64 53Medical Biophysics 80 0 80 61 2 0 19 63 229 150Medical Genetics & Microbiology 75 29 46 31 23 6 28 58 246 181Nutritional Sciences 27 15 12 18 8 3 3 19 71 5Pharmacology 32 16 16 32 3 3 3 17 40 3Physiology 46 29 17 66 16 4 17 36 190 103SUB-TOTAL 356 144 212 320 88 33 99 281 984 539COMMUNITY HEALTHHealth Policy, Mgmt & Eval 22 22 0 147 11 3 6 21 124 2Public Health Sciences 229 36 193 79 20 6 13 80 134 5SUB-TOTAL 251 58 193 226 31 9 19 101 258 7CLINICALAnesthesia 248 2 246 5 2 0 5 35 25 10Family & Community Medicine 805 0 805 26 1 0 2 18 14 7Lab. Medicine & Pathobiology 225 15 210 65 10 3 10 88 153 86Medical Imaging 169 2 167 21 1 0 1 20 14 11Medicine 927 26 901 89 5 0 79 328 280 220Obstetrics & Gynaecology 156 1 155 36 2 0 2 25 24 34Occupational Therapy 25 25 unk 1 5 3 2 14 173 2Ophthalmology And Vision Sci 133 3 130 11 1 0 4 19 16 15Otolaryngology 74 0 74 23 2 0 0 7 7 17Paediatrics 356 0 356 34 1 0 15 125 116 79Physical Therapy 29 24 5 11 6 5 3 25 202 3Psychiatry 677 0 677 53 2 0 15 123 83 48Radiation Oncology 117 0 117 6 0 0 3 25 22 unkSpeech-Language Pathology 11 11 0 6 6 3 3 9 145 unkSurgery 338 7 331 57 3 0 19 137 106 132SUB-TOTAL 4,290 116 4,174 444 47 14 163 998 1,380 664TOTAL 4,897 318 4,579 990 166 56 281 1,380 2,622 1,210Based on data received from each individual Department



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Prim Appt


FellowsBaycrest Centre for Geriatric Care 16 1 5 14Bloorview Kid's Rehab 8 3 0 5Centre for Addiction and Mental Health 83 16 44 no dataHospital for Sick Children 266 44 175 371Mount Sinai Hospital 118 20 151 174St. Michael's Hospital 179 31 41 43SHSC 100 Sunnybrook site 136 28 41 no breakdown Orthopaedic & Arthritic site 2 0 0 no breakdownToronto Rehabilitation Institute 26 2 20 25University Health Network 345 58 276 467Women's College Hospital 27 6 4 5TOTAL 1179 203 753 1199Hospital Post-doc numbers based on data provided by each individual hospital




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DEPARTMENT Nasm1

BASICBanting and Best Department of Medical Research 2065Biochemistry 1682Institute of Biomaterials & Biomedical Engineering 2 1129Immunology 789Molecular Genetics 2118Nutritional Sciences 1055Pharmacology 1618Physiology 1920


Sub-Total 1,818CLINICALOccupational Therapy 683Physical Therapy 1046Speech-Language Pathology 564Surgery (includes Anatomy Div.) 361

Sub-Total 2,654OTHERBiomedical Communications 117Centre for Research in Neurodegeneratice Disease 1458Centre for Cellular & Biomolecular Research (Terrence Donnelly) 5865Comparative Medicine 2386Common Research Space 1649Electron Microscopy Unit 241.22Heart & Stroke / Richard Lewar Centre for Excellence… 321Rehabilitation Sciences Sector 130Structural Genomics Consortium 1360


Based on a data extracted on: July 2006 and May 20071 Nasm - Net assignable square meters2 Includes ONLY IBBME research space at the MSB

Table 9




16




External - Other $1,943,210.63 $5,014,054.41 $6,957,265.04

External - Unspecified by Hospital $1,620,484.15 $1,963,883.40 $3,584,367.55

Internal - U of T $11,547,312.59 $3,229,854.11 $14,777,166.70

Grand Total $25,024,658.28 $19,481,090.98 $44,505,749.26


Type of Funding




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Graduate Unit AWARD STIPEND Grand TotalBiochemistry $1,350,619.68 $1,568,085.94 $2,918,705.62Graduate Department of Rehabilitation Science $928,937.91 $211,643.36 $1,140,581.27Health Policy, Management & Evaluation $1,870,115.88 $1,230,390.09 $3,100,505.97Immunology $983,852.82 $611,701.40 $1,595,554.22Institute of Biomaterials & Biomedical Engin. $1,439,091.80 $758,072.17 $2,197,163.97Institute of Medical Science $5,670,838.88 $5,151,769.82 $10,822,608.70Laboratory Medicine & Pathobiology $1,604,213.81 $1,518,780.19 $3,122,994.00Medical Biophysics $2,578,829.62 $702,489.76 $3,281,319.38Molecular Genetics $2,412,354.83 $3,533,233.09 $5,945,587.92Nutritional Sciences $859,180.18 $476,566.20 $1,335,746.38Occupational Health Sceince & Occupational Therapy $193,827.50 $400.00 $194,227.50Pharmacology $697,702.06 $534,656.92 $1,232,358.98Physical Therapy $336,451.00 $0.00 $336,451.00Physiology $1,509,588.39 $2,526,910.95 $4,036,499.34Public Health Sciences (Dalla Lana School of) $2,053,366.25 $551,449.65 $2,604,815.90Speech-Language Pathology $535,687.67 $104,941.44 $640,629.11


Type of Funding




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Awards Stipend1

Baycrest/Rotman Institute $19,500.00 $84,900.00 $104,400.00Bloorview Kid's Rehab $5,000.00 $0.00 $5,000.00Centre for Addiction and Mental Health $195,510.00 $418,984.00 $614,494.00Hospital For Sick Children $2,115,515.50 $2,119,425.43 $4,234,940.93Mount Sinai Hospital $365,950.00 $1,211,440.68 $1,577,390.68St. Michael's Hospital $254,175.00 $622,282.00 $876,457.00Sunnybrook Health Sciences Centre $546,400.00 $762,880.19 $1,309,280.19Toronto Rehabilitation Institute $125,000.00 $26,000.00 $151,000.00University Health Network $1,755,108.34 $2,261,879.11 $4,016,987.45Women's College Hospital $50,000.00 $25,000.00 $75,000.00Other $512,066.66 $655,184.39 $1,167,251.05

Off Campus Total $5,944,225.50 $8,187,975.80 $14,132,201.30











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20





21



Total Number of Awards: 109 Primary Appointments 248 On Campus 2 Off Campus 246 Cross Appointments 5 CIHR $1,425,268 Tenured 2 NSERC $26,768 Tenure-stream 0 NCIC $0 Career Awards 5 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 35 HSFO/C $0 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $1,092,835 Supervised by Primary Appt 25 Other Sources $2,803,184 Fellows: Post-Doc. and Clin. 10

Overall Research Objective : To develop the environment and recruit personnel for the generation of research of the highest quality necessary for the advancement of knowledge in the areas of interest to Anesthesia and Perioperative Care. Current Major Areas of Research : Faculty in the Department of Anesthesia have developed research interests and programs in a number of fields related to anesthesia, pain management and peri-operative medicine. These include the following major areas, each represented by an identified contact person. Please also visit the research section of our Departmental web site for more information (www.anesthesia.utoronto.ca). Acute Pain C. McCartney 603-5118 [email protected] Ambulatory Anesthesia F. Chung 603-5118 [email protected] Anesthesia mechanisms B. Orser 480-4864 [email protected] Anemia/Hypoxia Lab Research G. Hare 864-5259 [email protected] Blood Conservation K. Karkouti 340-5164 [email protected] Cardiovascular D. Mazer 864-5825 [email protected] Critical Care B. Kavanagh 813-8019 [email protected] Education V. Naik 864-5071 [email protected] Malignant Hyperthermia J. Loke 340-3128 [email protected] Neuroscience B. Orser 480-4864 [email protected] A. Baker 864-5510 [email protected] Obstetrical Management S. Halpern 323-6008 [email protected] Outcomes Research S. Beattie 340-5164 [email protected] Paediatrics M. Crawford 813-7445 [email protected] Pain mechanisms D. Joo 813-7445 [email protected] Regional Anesthesia V. Chan 340-3227 [email protected] Simulation P.Morgan 323,6269 [email protected] V. Naik 864-5071 [email protected] - Text last updated June 2008


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Total Number of Awards: 136 Primary Appointments 24 On Campus 22 Off Campus 2 Cross Appointments 2 CIHR $6,464,627 Tenured 11 NSERC $198,600 Tenure-stream 8 NCIC $839,589 Career Awards 8 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 25 HSFO/C $98,675 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $3,069,729 Supervised by Primary Appt 45 Other Sources $31,475,164 Fellows: Post-Doc. and Clin. 17

Overall Research Objective : To use proteomics, functional genomics and bioinformatics to achieve a comprehensive view of gene function, cell regulatory pathways and gene/protein networks. To understand the molecular basis of biological disorders. Current Major Areas of Research : • Cell cycle • Control of gene expression • Developmental biology • Functional genomics • Mechanism of action of hormones • Membrane structure and function • Muscle biology • Proteomics • Structural biology - Text last updated October 2008


23



Total Number of Awards: 227 Primary Appointments 34 On Campus 19 Off Campus 15 Cross Appointments 21 CIHR $5,432,531 Tenured 18 NSERC $540,054 Tenure-stream 1 NCIC $1,282,606 Career Awards 14 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 27 HSFO/C $255,341 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $464,165 Supervised by Primary Appt 97 Other Sources $8,383,012 Fellows: Post-Doc. and Clin. 17

Overall Research Objective : To advance and disseminate our understanding of the molecular fundamentals of life through first rate research and academic programs. Current Major Areas of Research : • Biomolecular structure and function • Gene expression and development • Membranes and transport • Molecular cell biology • Molecular medicine • Protein folding • Proteomics and Bioinformatics • Signal transduction and regulation - Text last updated June 2008


24



Total Number of Awards: 52 Primary Appointments 805 On Campus 0 Off Campus 805 Cross Appointments 26 CIHR $656,425 Tenured 1 NSERC $0 Tenure-stream 0 NCIC $0 Career Awards 2 HLTH CAN $854,927 With Research Funds MOH $3,607,226 Primary Appointments 18 HSFO/C $0 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $599,693 Supervised by Primary Appt 14 Other Sources $1,296,033 Fellows: Post-Doc. and Clin. 7


genetics, care of the elderly, prescribing and care of people with chronic disabling conditions • Improving population access to primary care - Text last updated June 2008


25



Total Number of Awards: 181 Primary Appointments 22 On Campus 22 Off Campus 0 Cross Appointments 147 CIHR $2,335,458 Tenured 11 NSERC $0 Tenure-stream 3 NCIC $0 Career Awards 6 HLTH CAN $197,745 With Research Funds MOH $1,393,744 Primary Appointments 21 HSFO/C $18,500 Cross Appointments unk SSHRC $59,149 Studentship Awards: Industry $0 Supervised by Primary Appt 124 Other Sources $3,639,166 Fellows: Post-Doc. and Clin. 2

Overall Research Objective : To contribute to knowledge, thereby advancing the discipline, improving teaching and improving the theory and practice of health services management and administration and clinical epidemiology. To educate researchers through the M.Sc./Ph.D. program and to foster an appreciation of the methods and application of health services research among graduate students. Current Major Areas of Research : • Clinical evaluative sciences • Financing of health services • Health measurement • Health care improvement • Health performance assessment • Health policy and economics • Organizational research • Outcomes research • Program planning and evaluation - Text last updated Jan 2009


26






27



Fac of Med primary appointments $2,329,627 Primary Appointments 11 On Campus 8 Total Number of Awards: 33 Off Campus 3 Cross Appointments 56 CIHR $992,395 Tenured 4 NSERC $118,915 Tenure-stream 5 NCIC $0 Career Awards 1 HLTH CAN $0 With Research Funds MOH $397,900 Primary Appointments 12 HSFO/C $187,239 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $57,000 Supervised by Primary Appt 2 Other Sources $576,178 Fellows: Post-Doc. and Clin. 10


cardiovascular and soft tissue biomaterials; stem cell bioengineering and functional genomics; drug delivery systems, tissue engineering scaffolds, host response and functional integration. Hemodynamics, cellular and tissue biomechanics, cellular engineering


• Molecular Imaging and Systems Biology: Scanning probe microscopy, quantum dots, genetic circuits, microarray technology development, microfluidics and MEMS, cellular systems modeling, single molecule biophysics, functional cellular imaging





28







atherosclerosis, ischemic heart disease, lipid disorders, and valvular disease - Text last updated June 2008


29



Total Number of Awards: 466 Primary Appointments 80 On Campus 0 Off Campus 80 Cross Appointments 61 CIHR $7,528,857 Tenured 2 NSERC $481,617 Tenure-stream 0 NCIC $5,368,241 Career Awards 19 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 63 HSFO/C $445,045 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $2,986,088 Supervised by Primary Appt 229 Other Sources $38,065,058 Fellows: Post-Doc. and Clin. 150

Overall Research Objective : To conduct basic and applied research related to human health with an emphasis on cancer. Current Major Areas of Research : • Angiogenesis • Animal models of human disease • Bioinformatics • Cancer biology • Cardiovascular Research • Developmental Biology • Digital radiography • Drug resistance mechanisms • Experimental therapeutics • Genomics/proteomics applied to medical research • High throughput structural genomics • Image guided therapeutics • Immunological tolerance and autoreactivity • Intracellular signalling pathways • Magentic resonance imaging • Macromolecular electron microscopy • Macromolecular structure and function • Molecular genetics of cancer • Molecular-Immunological mechanisms • Optical Imaging and therapy • Stem Cells • Ultras

- Text last updated january 2009


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DEPARTMENT: Molecular Genetics (formerly Medical Genetics & Microbiology)


Total Number of Awards: 537 Primary Appointments 75 On Campus 29 Off Campus 46 Cross Appointments 31 CIHR $15,777,350 Tenured 23 NSERC $492,338 Tenure-stream 6 NCIC $4,117,460 Career Awards 28 HLTH CAN $0 With Research Funds MOH $500,000 Primary Appointments 58 HSFO/C $68,792 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $2,484,383 Supervised by Primary Appt 246 Other Sources $37,194,725 Fellows: Post-Doc. and Clin. 181

Overall Research Objective : The mission of the Department of Molecular Genetics is to conduct world-class research and to train outstanding students in several cutting-edge research areas. Molecular biological, molecular genetic, cellular and systems biological approaches are applied tto studies in six research areas: 1) functional genomics and proteomics; 2) molecular biology and macromolecular structure; 3) molecular medicine and human genetics; 4) model organism genetics and genetic control of development; 5) cell biology and signal transduction; 6) systems biology, computational biology and bioinformatics; and 7) molecular microbiology, virology and infectious disease research. Our aims are to: 1. Establish and/or maintain internationally competitive research programs in the areas listed above; 2. train future generations of independent scientists. Current Major Areas of Research : Signal transduction and cell regulation - Cell cycle and growth control - Transcriptional and post-transcriptional regulation of gene expression - Epigenetics and chromatin regulation - Chromosome dynamics and biology - Functional genomics - Nucleic acid metabolism and function - Structural biology using X-ray crystallography and NMR spectroscopy - Proteomics - Systems biological and bioinformatic analysis of gene regulatory networks, protein interaction networks, cell cycle and development - Analyses of complex genetic disease and single gene disorders - Disease gene mapping and identification - Genome annotation - Cell biology and developmental biology of disease states - Human chromosome structure, function and dynamics - Molecular diagnostics and gene therapy - Yeast, worm, fly, zebrafish, frog and mouse models of development - Stem cell research, haematopoiesis and cancer stem cells - Neurogenesis and neurobiology - Host-pathogen (viral, bacterial, fungal) interaction - Viral and plasmid segregation - Viral RNA transport and processing Departmental Website: http://www.utoronto.ca/moleculargenetics/ - Text last updated June 2008


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Total Number of Awards: 63 Primary Appointments 169 On Campus 2 Off Campus 167 Cross Appointments 21 CIHR $633,858 Tenured 1 NSERC $40,000 Tenure-stream 0 NCIC $72,088 Career Awards 1 HLTH CAN $0 With Research Funds MOH $860,322 Primary Appointments 20 HSFO/C $114,000 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $663,951 Supervised by Primary Appt 14 Other Sources $3,956,556 Fellows: Post-Doc. and Clin. 11

Overall Research Objective : Characterization of the structure and function of normal and diseased tissue using all modern imaging methods. Physiologically specific imaging at the metabolic, cellular, vascular and tissue level, using MRS, PET, MRI and MEG. Current Major Areas of Research : • Clinical trials of new contrast agents and drugs • Design of new imaging techniques and imaging systems • Integration of imaging data • Magnetic resonance imaging and spectroscopy • MEG and MSI • Minimally invasive diagnosis and therapy • Molecular imaging • Percutaneous and transvascular treatment methods • PET/CT • Picture archival and communications systems (PACS) • Real-time imaging • Tissue characterization by imaging - Text last updated June 2008


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Total Number of Awards: 1521 Primary Appointments 927 On Campus 26 Off Campus 901 Cross Appointments 89 CIHR $30,912,133 Tenured 5 NSERC $167,447 Tenure-stream 0 NCIC $1,869,606 Career Awards 79 HLTH CAN $449,178 With Research Funds MOH $1,168,155 Primary Appointments 328 HSFO/C $6,003,286 Cross Appointments unk SSHRC $47,900 Studentship Awards: Industry $16,863,075 Supervised by Primary Appt 280 Other Sources $57,766,952 Fellows: Post-Doc. and Clin. 220












osteoporosis, musculoskeletal disease in the community & work force. - Text last updated June 2008


33



Total Number of Awards: 139 Primary Appointments 27 On Campus 15 Off Campus 12 Cross Appointments 18 CIHR $1,690,174 Tenured 8 NSERC $735,017 Tenure-stream 3 NCIC $0 Career Awards 3 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 19 HSFO/C $0 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $1,207,793 Supervised by Primary Appt 71 Other Sources $1,922,759 Fellows: Post-Doc. and Clin. 5



34



Total Number of Awards: 93 Primary Appointments 156 On Campus 1 Off Campus 155 Cross Appointments 36 CIHR $4,984,250 Tenured 2 NSERC $72,500 Tenure-stream 0 NCIC $0 Career Awards 2 HLTH CAN $0 With Research Funds MOH $119,200 Primary Appointments 25 HSFO/C $0 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $738,576 Supervised by Primary Appt 24 Other Sources $2,233,376 Fellows: Post-Doc. and Clin. 34

Overall Research Objective : To achieve International recognition as a centre of excellence in women’s health research Current Major Areas of Research : • Clinical and basic perinatology • Control of parturition • Gynecologic cancers • Health services and health outcomes • Medical education • Minimally-invasive surgery • Molecular control of early fetal and placental growth • Multicentre perinatal randomized controlled trials • Paediatric and adolescent gynecology • Reproductive biology • Urogynecology and pelvic floor disorders • Developmental origins of adult health and disease - Text last updated January 2009


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Total Number of Awards: 212 Primary Appointments 25 On Campus 25 Off Campus unk Cross Appointments 1 CIHR $205,822 Tenured 5 NSERC $55,745 Tenure-stream 3 NCIC $0 Career Awards 2 HLTH CAN $0 With Research Funds MOH $61,250 Primary Appointments 14 HSFO/C $14,550 Cross Appointments unk SSHRC $66,289 Studentship Awards: Industry $0 Supervised by Primary Appt 173 Other Sources $1,554,544 Fellows: Post-Doc. and Clin. 2 Overall Research Objective : The Department of Occupational Science and Occupational Therapy will focus its science on advancing the knowledge of occupation and its enablement. The systematic study of daily occupations and their meanings in the lives of people of all ages and abilities will serve to improve the life and well being of individuals, families, groups, communities and societies, breaking through barriers encountered in all aspects of daily living. Current Major Areas of Research :












B. Kirsch Work reintegration of mental health consumers, models of community support in mental health S. Langlois Quality management, evidence-based practice, multiprofessional education P. McKee Orthotic intervention - principles and design, return to work issues for injured workers A. Mihailidis Assistive technology, cognition and dementia, artificial intelligence, ‘smart’ homes for older adults H. Polatajko Occupation, enablement, client-centred practice, children’s dev. coordination disorder, cognitive treatment approaches S. Rappolt Continuing professional education, return to work, rehabilitation services delivery D. Reid Child/adolescent development, disability and handicap, assistive technology, measurement of visual perception R. Renwick Quality of life for adults , children and families, person-environment rel. health promo, independent community living P. Rigby Dev.& eval of OT practice and model of child-environment fit dev and cost-utileval of assistive technologies R. Stack J. Stier B. Trentham

Fieldwork education and assessment Educational assessments, evaluation tools, knowledge translation, professional development Aging and impacts of marginalization on participation. Diversity and inclusion processes in education and practice



36



Total Number of Awards: 72 Primary Appointments 133 On Campus 3 Off Campus 130 Cross Appointments 11 CIHR $712,678 Tenured 1 NSERC $0 Tenure-stream 0 NCIC $249,016 Career Awards 4 HLTH CAN $0 With Research Funds MOH $1,234,347 Primary Appointments 19 HSFO/C $0 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $528,225 Supervised by Primary Appt 16 Other Sources $1,919,090 Fellows: Post-Doc. and Clin. 15

Overall Research Objective : To conduct fundamental research on the eye and visual processing and to apply this knowledge to the alleviation of ocular disease and the prevention of blindness. Current Major Areas of Research : • Cancer of the eye and orbit • Corneal external diseases • Corneal transplantation • Diabetic retinopathy • Glaucoma: diagnosis and therapeutics • Hereditary retinal degenerations: molecular genetics • Lacrimal investigation • Ocular infectious diseases • Ophthalmic Epidemiology • Paediatric ophthalmology • Retinal Imaging • Retinitis pigmentosa • Strabismus and Eye Movement • Ultrasound biomicroscopy • Visual electrophysiology and psychophysics - Text last updated January 2009


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DEPARTMENT: Otolaryngology – Head and Neck Surgery


Total Number of Awards: 15 Primary Appointments 74 On Campus 0 Off Campus 74 Cross Appointments 23 CIHR $197,149 Tenured 2 NSERC $0 Tenure-stream 0 NCIC $0 Career Awards HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 7 HSFO/C $0 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $32,500 Supervised by Primary Appt 7 Other Sources $355,102 Fellows: Post-Doc. and Clin. 17

Overall Research Objective : To further our basic understanding of the inner ear, upper respiratory tract, and disorders of the neck and skull base. Current Major Areas of Research : • Auditory physiology and pathophysiology • Cochlear implants: basic and applied issues • Head and neck oncology: treatment and epidemiology • Hearing loss and associated communication disorders • Laryngeal cancer histopathology • Neonatal hearing loss • Psychoacoustics • Temporal bone histopathology • Upper respiratory tract • Vestibular and oculomotor topics: clinical and basic - Text last updated June 2008


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Total Number of Awards: 495 Primary Appointments 356 On Campus 0 Off Campus 356 Cross Appointments 34 CIHR $20,028,593 Tenured 1 NSERC $70,735 Tenure-stream 0 NCIC $877,397 Career Awards 15 HLTH CAN $76,442 With Research Funds MOH $304,040 Primary Appointments 125 HSFO/C $1,092,190 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $2,477,200 Supervised by Primary Appt 116 Other Sources $21,914,702 Fellows: Post-Doc. and Clin. 79

Overall Research Objective : To study mechanisms of disease and health maintenance in infants and children utilizing molecular, biochemical and epidemiological methods. Current Major Areas of Research : • Brain and behavioural research • Cancer and blood research • Cardiovascular research • Cell biology • Developmental biology • Genetics and genomic biology • Infection, immunity, injury and repair research • Integrative biology • Metabolic research • Population health science • Structural biology and biochemistry - Text last updated October 2008


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DEPARTMENT: Pharmacology and Toxicology




Overall Research Objective : To investigate and understand the interaction of chemical compounds with living systems. To strengthen the department through the development of research related to the mechanisms of drug action and toxicity. Current Major Areas of Research : • Behavioural pharmacology and drug addiction • Biochemical and molecular pharmacology • Clinical pharmacology • Drug metabolism and distribution • Drug safety and toxicology • Neuropharmacology and psychopharmacology • Pharmacogenetics • Receptor pharmacology • Second messengers and signal transduction - Text last updated June 2008



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Total Number of Awards: 244 Primary Appointments 29 On Campus 24 Off Campus 5 Cross Appointments 11 CIHR $527,261 Tenured 6 NSERC $26,768 Tenure-stream 5 NCIC $0 Career Awards 3 HLTH CAN $0 With Research Funds MOH $439,812 Primary Appointments 25 HSFO/C $252,838 Cross Appointments unk SSHRC $1,023 Studentship Awards: Industry $0 Supervised by Primary Appt 202 Other Sources $1,480,114 Fellows: Post-Doc. and Clin. 3


continuum care - Text last updated June 2008


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Overall Research Objective: Key Priorities:

• To expand and enrich four key areas of research represented by our Research Platforms: o Brain Research and Integrative Neurophysiology o Cardiovascular o Reproduction & Development o Endocrinology & Diabetes

• To foster a research culture in which all aspects of discovery are explored. • To integrate our research activities with the clinical and research activities of our sister

hospital-based research institutes. • To develop and foster partnerships with University of Toronto-affiliated research institutes

and centres, as well as national and international centres of excellence. • To recruit and retain the best researchers in our key research areas. • To provide an outstanding environment for post-doctoral and graduate trainees. • To provide specialized undergraduate teaching to Arts & Science students with the

objective of attracting the best students into our graduate program. • To create and maintain a supportive environment for clinician scientists.

Key Challenges: • To develop and maintain world-class research infrastructure for faculty. • To develop advancement strategies that enhance research capacity and infrastructure in

the Department. • To expand competitive funding for research and training initiatives between the

Department of Physiology and our international, national and local research partner Current Major Areas of Research:

o Brain Research and Integrative Neurophysiology o Cardiovascular o Reproduction & Development o Endocrinology & Diabetes

www.physiology.utoronto.ca - Text last updated June 2008


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Total Number of Awards: 378 Primary Appointments 677 On Campus 0 Off Campus 677 Cross Appointments 53 CIHR $8,317,110 Tenured 2 NSERC $66,436 Tenure-stream 0 NCIC $132,614 Career Awards 15 HLTH CAN $0 With Research Funds MOH $368,132 Primary Appointments 123 HSFO/C $140,104 Cross Appointments unk SSHRC $687,791 Studentship Awards: Industry $2,135,243 Supervised by Primary Appt 83 Other Sources $10,420,553 Fellows: Post-Doc. and Clin. 48

Overall Research Objective: The overarching goals of research in the Department of Psychiatry are to increase our understanding of the determinants of psychiatric illness, the mechanisms which contribute to the development of mental illness, and to develop more effective interventions to reduce the burden of mental illness. Current Major Areas of Research : The Department of Psychiatry supports major research programs in multiple fields including schizophrenia, mood disorders, geriatric psychiatry, child psychiatry, forensic psychiatry, psychotherapy, women’s mental health, addictions, neuroscience, psychosomatic medicine, health systems, general psychiatry, cultural psychiatry and education. - Text last updated October 2008


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DEPARTMENT: Public Health (Dalla Lana School of), formerly Public Health Sciences




infectious disease, chronic disease(eg. Arthritis, diabetes), accidents and injuries • Gerontology health and aging • Health professions and organizations • Health promotion and disease prevention • Methodological research in epidemiology, biostatistics and demography • Methodology: qualitative, quantitative, evaluation • Occupational and environmental health • Prevention of transmission of HIV/AIDS - Text last updated June 2008


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Total Number of Awards: 92 Primary Appointments 117 On Campus 0 Off Campus 117 Cross Appointments 6 CIHR $962,461 Tenured 0 NSERC $25,768 Tenure-stream 0 NCIC $609,119 Career Awards 3 HLTH CAN $0 With Research Funds MOH $60,375 Primary Appointments 25 HSFO/C $0 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $1,897,550 Supervised by Primary Appt 22 Other Sources $9,850,522 Fellows: Post-Doc. and Clin. unk

Overall Research Objective : Excellence in clinical and translational, basic science, and physics and imaging research related to radiation medicine. Current Major Areas of Research : • Image guided radiation therapy • Molecular radiation biology of tumour and normal tissues • Clinical trials • Drug-radiation interactions • Tumour microenvironment and treatment outcome • Health services and outcomes research For more information about the Department of Radiation Oncology contact: Dr. Anthony Fyles 416-946-6522 [email protected] - Text last updated June 2008


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Total Number of Awards: 166 Primary Appointments 11 On Campus 11 Off Campus 0 Cross Appointments 6 CIHR $338,815 Tenured 6 NSERC $29,789 Tenure-stream 3 NCIC $0 Career Awards 3 HLTH CAN $0 With Research Funds MOH $45,100 Primary Appointments 9 HSFO/C $89,170 Cross Appointments unk SSHRC $90,052 Studentship Awards: Industry $105,003 Supervised by Primary Appt 145 Other Sources $798,476 Fellows: Post-Doc. and Clin. unk

Overall Research Objective : To advance knowledge of the neurological, behavioural, and social aspects of communication and swallowing. There are two primary foci: normal and disordered speech and swallowing, and language development and disorders across the lifespan. Research linkages have been forged through collaborative projects with engineering, neurological imaging, dentistry, linguistics, psychiatry and otolaryngology among others. Another research objective is to develop improved models of clinical management of communication disorders. Clinical research is being undertaken in the areas of augmentative and alternative communication, speech fluency, developmental language disorders, hearing loss, aphasia and apraxia of speech, normal speech production, awallowing, modelling of the tongue and vocal tract, neurodegenerative diseases and models of supervision, among others. Current Major Areas of Research : Members of the Graduate Department of Speech-Language Pathology pursue research in the following major areas, each represented by a contact person identified below. For more information about our three graduate programs and a detailed list of faculty and their research, please inquire at 500 University Avenue, 10th Floor. (or vist our website: www.slp.utoronto.ca) Motor speech disorders and swallowing C. Steele 978-8330 Developmental speech and language disorders L. Girolametto 978-3353 Acquired language disorders (aphasia and dementia) E. Rochon 978-8332 Voice and resonance disorders T. Bressmann 978-7088 Speech motor control and stuttering L. De Nil 978-1789 Augmentative and alternative communication and ALS Y. Yunusova 978-6890 Developmental speech and language disorders C. Johnson 978-8331 Speech physiology and speech motor control P. Van Lieshout 978-8334 Childhood hearing loss A. Eriks-Brophy 946-8633 Swallowing R. Matino 946-8644 Stuttering R. Kroll 978-1789 International Rehabilitation P. Parnes 946-8556 Aphasia Treatment Outcomes A. Kagan 978-2770 Auditory Physiology J. Mendelson 978-2770 Literacy and Treatment Outcomes M.Thelander 978-2770 Otolaryngology J. Irish 978-2770 - Text last updated June 2008


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DEPARTMENT: Surgery




World countries) - Text last updated June 2008


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48








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Total Number of Awards: 36 Research Funds 16 Career Awards 1 CIHR $1,699,472 Studentship Grant Awards: NSERC $26,000 NCIC $0 Supervised by Investigator 5 HLTH CAN $0 MOH $0 Fellows: HSFO/C $1,085,061 SSHRC $0 Post-Doc. and Clin. 14 Industry $80,996 Other Sources $562,518



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Total Number of Awards: 17 Research Funds 8 Career Awards 3 CIHR $0 Studentship Grant Awards: NSERC $25,415 NCIC $0 Supervised by Investigator HLTH CAN $0 MOH $0 Fellows: HSFO/C $0 SSHRC $0 Post-Doc. and Clin. 5 Industry $37,000 Other Sources $349,214



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Total Number of Awards: 256 Research Funds 83 Career Awards 16 CIHR $6,126,470 Studentship Grant Awards: NSERC $48,127 NCIC $0 Supervised by Investigator 44 HLTH CAN $40,090 MOH $4,205,952 Fellows: HSFO/C $89,159 SSHRC $364,970 Post-Doc. and Clin. unk Industry $2,551,990 Other Sources $11,973,416



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Total Number of Awards: 1055 Research Funds 266 Career Awards 44 CIHR $23,300,470 Studentship Grant Awards: NSERC $561,588 NCIC $3,726,382 Supervised by Investigator 175 HLTH CAN $76,442 MOH $560,831 Fellows: HSFO/C $2,467,126 SSHRC $0 Post-Doc. and Clin. 371 Industry $6,288,657 Other Sources $63,802,878



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Total Number of Awards: 588 Research Funds 118 Career Awards 20 CIHR $17,515,326 Studentship Grant Awards: NSERC $394,016 NCIC $3,555,622 Supervised by Investigator 151 HLTH CAN $0 MOH $74,163 Fellows: HSFO/C $496,010 SSHRC $0 Post-Doc. and Clin. 174 Industry $5,165,018 Other Sources $25,756,551



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Total Number of Awards: 699 Research Funds 179 Career Awards 31 CIHR $7,652,435 Studentship Grant Awards: NSERC $224,188 NCIC $3,603 Supervised by Investigator 41 HLTH CAN $603,610 MOH $3,562,278 Fellows: HSFO/C $1,240,237 SSHRC $47,900 Post-Doc. and Clin. 43 Industry $7,288,611 Other Sources $21,486,508



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Total Number of Awards: 2 Research Funds 2 Career Awards CIHR $0 Studentship Grant Awards: NSERC $0 NCIC $0 Supervised by Investigator HLTH CAN $0 MOH $0 Fellows: HSFO/C $0 SSHRC $0 Post-Doc. and Clin. unk Industry $0 Other Sources $25,000



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Total Number of Awards: 372 Research Funds 136 Career Awards 28 CIHR $8,614,216 Studentship Grant Awards: NSERC $229,250 NCIC $2,964,978 Supervised by Investigator 41 HLTH CAN $0 MOH $1,722,093 Fellows: HSFO/C $2,375,898 SSHRC $0 Post-Doc. and Clin. 100 Industry $3,897,055 Other Sources $31,219,154







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Total Number of Awards: 101 Research Funds 26 Career Awards 2 CIHR $960,345 Studentship Grant Awards: NSERC $53,054 NCIC $0 Supervised by Investigator 20 HLTH CAN $0 MOH $3,514,296 Fellows: HSFO/C $186,815 SSHRC $0 Post-Doc. and Clin. 25 Industry $145,003 Other Sources $5,071,585



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Total Number of Awards: 57 Research Funds 27 Career Awards 6 CIHR $4,030,204 Studentship Grant Awards: NSERC $0 NCIC $0 Supervised by Investigator 4 HLTH CAN $0 MOH $384,911 Fellows: HSFO/C $0 SSHRC $0 Post-Doc. and Clin. 5 Industry $166,019 Other Sources $2,552,711



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CENTRE: Banting and Best Diabetes Centre Total Membership: 148 (107 of whom are U of T Faculty) Number of Graduate Studentships Awarded in 2007-2008: 14 Number of Postdoctoral Fellowships Awarded in 2007-2008: 4 Participating Departments : • Anaesthesia • Anthropology • Banting and Best Dept. of Medical




Other Participants : • Canadian Diabetes Association • TriHospital Diabetes Education Centre • Samuel Lunenfeld Research Institute • Hospital for Sick Children Research Institute • Toronto General Research Institute • Toronto Western Research Institute Overall Research Objective : To foster programs of research, education and patient care in diabetes at the University of Toronto and its affiliated hospitals. To develop an endowment to support the activities of the Centre and to establish new research programs in areas related to diabetes in a number of clinical and basic sciences departments of the Faculty. Current Major Areas of Research : • Atherosclerosis • Clinical trials • Complications of diabetes • Diabetic nephropathy • Genetics of diabetes • Glucagon related peptides • Gut hormones • Immunology of diabetes • Insulin secretion • Insulin signaling • Integrative biology • Lipoprotein kinetics • Membrane biology • Molecular biology • Molecular genetics and evolution - Text last updated December 2008


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CENTRE: Joint Centre for Bioethics The University of Toronto Joint Centre for Bioethics is a partnership among the University of Toronto, Baycrest Centre for Geriatric Care, Bloorview Kids Rehab, Centre for Addiction and Mental Health, Centre for Clinical Ethics , a joint venture of Providence Healthcare, St. Joseph’s Health Centre and St. Michael’s Hospital, The Hospital for Sick Children, Humber River Regional Hospital, Mount Sinai Hospital, North York General Hospital, Ontatrio Genomics Institute, Sunnybrook Health Sciences Centre, Toronto Community Care Access Centre, Toronto East General Hospital, Toronto Rehabilitation Institute, Trillium Health Centre and University Health Network (Princess Margaret Hospital, Toronto General Hospital, and Toronto Western Hospital) . The mission of the Joint Centre is to provide leadership in bioethics research, education, practice and public engagement.. Students, Research Assistants and Fellows : The Joint Centre for Bioethics has a formal doctoral-stream Collaborative Program in Bioethics through the School of Graduate Studies. The participating graduate units are: Department of Health Policy, Management and Evaluation, Institute of Medical Science, Faculty of Law, Faculty of Nursing, Faculty of Social Work, Graduate Department of Rehabilitation Sciences, Department of Philosophy, Dalla Lana School of Public Health and Department and Centre for the Study of Religion. The Joint Centre for Bioethics also has a professional MHSc degree in Bioethics through the Institute of Medical Science. Participating Departments in the Faculty : Almost all the departments in the Faculty participate in the Joint Centre for Bioethics. There are academic fellowships in clinical and organizational ethics and research grants support fellows, graduate students and research associates and assistants in specific projects. Other Participating Faculties and Departments : Arts and Science, Law, Management, Social Work and Nursing Overall Research Objective : To improve healthcare through leadership in bioethics research, education, practice and public engagement. Current Major Areas of Research : • Canadian Priority Setting Research Network (CPSRN) • Canadian Program on Research on Ethics in a Pendemic (CanPREP) • Clinical, Organizational and Research Ethics (CORE) Network • Organizational Ethics Research Group • Project to Examine Effectiveness in Clinical Ethics • Public Health Ethics Interest Group • Research and Education in Research Ethics • Rehab and Continuing Care Ethics Research Group • Mental Health Ethics • - Text last updated December 2008


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Faculty of Applied Sciences & Engineering • Department of Chemical Engineering & Applied Chemistry • Department of Electrical & Computer Engineering Faculty of Arts & Science • Department of Computer Science • Department of Chemistry • Department of Physics






- Text last updated December 2008


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CENTRE: Clinical Science Division Academic Staff : 27 Students & Fellows : Graduate Students 41 Post-doctoral & Clinical Research Fellows 28 Participating Departments in the Faculty : • Medicine • Surgery Overall Research Objective : To foster a strong intellectual environment for clinician-scientists and basic scientists to undertake research programs alone, or in collaboration with one of the major research groupings and to provide a superior milieu for the training of research fellows and graduate students. Current Major Areas of Research : • Molecular Medicine Program • Cardiovascular sciences • Gastroenterology/Nutrition • Hematology/Oncology • Infectious diseases/HIV • Renal physiology/pathophysiology • Respiratory sciences - Text last updated December 2008


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CENTRE: The Wilson Centre for Research in Education The Wilson Centre for Research in Education www.thewilsoncentre.ca is dedicated to advance healthcare education and practice through research. It is designed to bring together health professional educators, basic scientists, clinical and rehabilitation scientists and community healthcare professionals for the purpose of conducting research aimed at improving curriculum, teaching, learning and evaluation. The overarching mission of the Wilson Centre is to i) foster the discovery and application of new knowledge relevant to advancing healthcare education and practice ii) promote creative synergies between diverse theoretical perspectives and between theory and practice, and iii) to be a world leader in education. Core Academic Staff : 10 Administrative Staff : 4



Evaluation • Institute of Medical Science • Laboratory Medicine & Pathobiology • Medicine • Obstetrics & Gynaecology • Occupational Therapy • Otolaryngology

• Paediatrics • Physical Therapy • Psychiatry • Public Health Sciences • Medical Imaging • Radiation Oncology • Rehabiliation Sciences Sector • Speech-Language Pathology • Surgery

Other Participating Faculties & Departments : OISE/UT, Library and Information Science, Institute for Medical Science, Standardized Patient Program, Network of Excellence in Simulation for Clinical Teaching and Learning at Mt. Sinai Hospital (NESCTL), Surgical Skills Centre at Mount Sinai Hospital, Centre for Faculty Development at St. Michael’s Hospital, Program in eHealth Innovation, Faculty of Medicine Acadamies; Faculty of Nursing, Faculty of Dentistry, Faculty of Pharmacy, Michener Institute, Departments of Kinesiology, Psychology, Sociology, English and Engineering, Knowledge Media Design Inst, UoT, Ctr for Int'l Health, Dalla Lana School of Public Health UoT. Other Participants : Conestoga College Institute of Technology & Advanced Learning, Interprofessional Education at Bridgepoint Health, The Peter A. Silverman Centre for International Health at MSH, Ontario Medical Schools, Addis Ababa University in Ethiopia, Technion Medical School, Haifa, Israel and Imperial College, London, England. Participating Hospitals : All teaching hospitals affiliated with the University of Toronto. Overall Research Objective : To advance healthcare education and practice through research. Current Major Areas of Research : Programs of research which are drawn from: learners and learning environments and their evaluation and improvement, teachers and teaching evaluation and improvement, informatics in health professional education, interprofessional skills including team work communications, factors affecting diagnostic decision making, the psychometrics of performance-based assessment and the sociology of health professional education research, professionalism and healthcare delivery, computer assisted instruction, clinical and technical skills simulation and assessment, communication skills simulation and assessment, curriculum development and evaluation, interdisciplinary projects in cognitive sciences regarding clinical problem solving, critical thinking and memory, patient safety and medical error, the development of and changes in sciences, Health Sciences Faculties collaborative projects related to educational and practice outcomes of health professional education and faculty development. - Text last updated: December 8, 2008


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PostDoctoral Fellows: 0 Studentship Awards: N/A Participating Departments in the Faculty : • Public Health Sciences Other Participants: • University Health Service, Health News Other Participating Faculties & Departments: • Centre for Urban and Community

Studies • Department of Sociology

• Nursing • OISE/UT

Participating Organizations : • Centre for Addiction & Mental Health • Promotion & Programs Branch, Ontario Regional Office, Public Health Agency of Canada • Health Nexus • Ministry of Health Promotion • Toronto Public Health • Centre for Urban Health Initiatives • Centre for International Health • Canadian Society for International Health • IUHPE-International Union of Health Promotion and Education • PAHO-Pan American Health Organization • WHO-World Health Organization Overall Research Objective : To develop a program of applied evaluation research in health promotion provincially, nationally and internationally. Current Major Areas of Research : • Youth friendly primary health services • Mental health promotion • Workplace health promotion • Economic Evaluation in health promotion • First Peoples’ Health Promotion - Text last updated December 2008


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CENTRE: Centre for International Health, Dalla Lana School of Public Health

The Centre for International Health is committed to advancing the research agenda of the University and improving the 10/90 gap in global health research, where 90% of the world’s health research is focused on only 10% of the world’s health burden, by developing and facilitating multidisciplinary global health research and education opportunities with the Dalla Lana School of Public Health, departments in the Faculty of Medicine, the University of Toronto in general, other universities and organizations. The CIH enables and implements global health research, education and advocacy. Collaborations continue with the Centre for Global Health Research at St. Michael’s Hospital, Office of International Surgery, Sprinkles, Sickkids International, the Global Pediatric Research Program, the MAA/CIH overseas research elective program and the International Centre for Disability and Rehabilitation. The CIH has developed into a national and international preeminent centre for scholarship and education. It enables and facilitates ideas, research and education to advance the University’s research priority. In 2007-08 the CIH continues with its: five year AUCC/CIDA funded (Tier 2) collaboration with the University of Port Harcourt, Nigeria to research on and develop human resources needed to combat HIV/AIDS; continued research on rural health system reform through collaborations with the China National Health Economics Institute and Kunming Medical College; collaboration with Capital Medical University in Beijing to study and implement the teaching of family/general practice medicine; and facilitated student initiated primary health care research in Cambodia, at its field station program in Kep and in hospitals in the capital city, Phnom Penh. The CIH has recently hosted four post doctoral students: Dr. Daniel Hollenberg studying integrated medicine in Canada; Dr. Daniel Sahleyesus studying HIV/AIDS orphans and vulnerable children in Ethiopia; Dr. Stephanie Nixon studying HIV/AIDS at the Health Economics Research Division at the University of Kwazulu Natal in Durban, South Africa; Dr. Youde Guo, from Fudan University, Shanghai, studying health policy and organization in Canada. Participating Departments and Units in the Faculty of Medicine (selected): • Health Policy, Management & Evaluation • Family and Community Medicine • Otolaryngology • Pediatrics • Psychiatry

Rehabilitation Sciences • Surgery • Obstetrics and Gynaecology • Medicine & Infectious Disease & Emergency


Other Multidisciplinary Collaborations (selected) : • OISE • Faculty of Physical


Science




Overall Research Objective: Implementing, facilitating and supporting multidisciplinary research focused on issues of relating to health problems affecting the world’s poorest and most vulnerable populations. Current Major Areas of Research: • Primary Health Care Development – Cambodia • Rural Health System Reform – China • Urban Community Health Development - China • HIV/AIDS –Zambia, Namibia,Tanzania, Nigeria and Kenya; South Africa, Ethiopia and Malawi • Global Health Education for Medical Residents • Interprofessional Education in Global Health

With funds from the Medical Alumni Association, the CIH sends students to international sites to carry out research and elective projects. • Total Number of Studentship MAA Research Awards =13 • Total Number of Overseas Electives = 20 Further information from: http://intlhealth.med.utoronto.ca or Dr. David Zakus, Director ([email protected]). - Text last updated: December, 2008


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Engineering






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The mission of the Heart & Stroke/Richard Lewar Centre of Excellence (HSRLCE) is to bring the best of cardiovascular sciences at the University of Toronto together, including basic sciences, clinical investigations, and community health. Research at the Centre is focused on the prevention and cure of atheroslerosis, hypertension, heart failure and congenital heart disease. From this research will evolve diagnostic, prognostic, and therapeutic innovations that can impact on the health of all Canadians. Since its inception in 1999, the Centre has attracted over 95 principal investigators across the University’s campus, including the disciplines of cardiology, cardiovascular surgery, genetics, immunology, health services research, laboratory medicine and pathobiology, phsiology, physical therapy, psychology and and biomedical engineering. Working groups within the Centre have leveraged several large group grants, including ones on transgenic physiology, vascular biology, heart failure, and health outcomes research. The Centre also supports research studentships and fellowships, and has received a national, large-scale strategic training program grant from the CIHR Institutes of Circulatory and Respiratory Health, Genetics and Health Services Policy Research and the Heart and Stroke Foundation. The Centre supplements this program with its own fellowship and graduate studentship funding program, and hosts a number of educational events to facilitate enhanced collaborative research across institutions and disciplines. Trainee support : Total number of Studentship Awards: 23 Total number of Post-doctoral for Clinical Fellows (involved in research): 58 Participating Departments: Anaesthesia, Chemical Engineering & Applied Chemistry, Banting & Best Department of Medical Research, Biochemistry, Institute of Biomaterials & Biomedical Engineering, Laboratory Medicine & Pathobiology, Mechanical & Industrial Engineering, Medical Biophysics, Medicine, Molecular and Medical Genetics, Obstetrics & Gynaecology, Pharmacology, Physical Therapy, Physiology, Psychology and Surgery Overall Research Objective : Recruitment of top level scientists within focused priority programs. Development of collaborative infrastructure to facilitate knowledge, technique sharing, and the specific goals of our research programs. Formation of distinct research platforms with identified leaders and infrastructure to develop programs to answer key questions. Training of the next generation of research leaders (facilitated by our Fellowship Program). Improved communication, collaboration and enhanced profile within the local cardiovascular community. Current Major Areas of Research : For the next five years, the Centre’s research priorities are: Mechanistic studies of cardiovascular disease: a) transgenic mouse models, b) large animal models, c) integrative human physiology d) cardiovascular imaging Innovative cardiovascular therapeutics: a) personalized medicine, b) regenerative medicine including stem cells and gene therapy, tissue engineering, c) clinical genomics & proteomics, biomarkers of heart failure, d) special foci of interests are:

• Atherosclerosis, Hypertension, and Vascular Biology • Heart Failure and Transplantation • Arrhythmias • Congenitial Heart Disease • Diabetes and Cardiovascular Medicine

- Text last updated December 2008


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degenerations, ALS, Parkinson’s Disease • Brain trophic factors and neuron rescue • Cytoskeletal proteins in health and neurodegenerative disease • Gene expression in Alzheimer's Disease • Genetic basis of familial neurodegenerative disease • Genetics of Amyotrophic Lateral Sclerosis (Lou Gehrig’s Disease) • Genetics of Parkinson’s Disease • Genetics of spinocerebellar ataxias • Pharmacokinetics of anti-dementia drugs • Protein structure, protein-protein interactions • Molecular and cell biology of amyloid, α-synuclein, tau, progranulin, TBP43, peripherin • Developmental neurobiology • Axon guidance and sprouting - Text last updated December 2008


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CENTRE: Centre for The Study of Pain Participating Departments in the Faculty: • Anaesthesia • Biomedical Communications • Medicine • Occupational Therapy • Paediatrics • Pharmacology • Physical Therapy • Physiology • Surgery Other Participating Faculties & Departments: • Dentistry • Library & Information Science • Nursing • Pharmacy • Social Work Other Affiliates: Comprehensive Pain Program, Toronto Western Hospital, Wasser Pain Management Centre and Mount Sinai Hospital Overall Research Objective : The University of Toronto Centre for the Study of Pain is a partnership involving the Faculties of Dentistry, Medicine, Nursing and Pharmacy. The mission of the Centre is to lead, both nationally and internationally, in pain research, education, and clinical activities. The vision of the Centre is to be a model of interdisciplinary collaboration to create and disseminate knowledge about pain, and to promote excellence in scholarship. The main goals of the Centre are to foster research and scholarship leading to an understanding of the mechanisms of pain and its alleviation; link research and education in pain so as to effect the dissemination and application of new knowledge in pain; develop, implement and support coordinated educational programs in pain at undergraduate, graduate and post-graduate levels; foster a multi-disciplinary approach in clinical research activities in pain, including collaboration between basic and clinical science; develop and provide continuing education programs for health care providers aimed at the dissemination of information derived from research and clinical evidence. Current educational activities of the Centre include an intensive week-long multi-disciplinary course in pain focusing on pain assessment and management for undergraduate students within the various health sciences disciplines at the University of Toronto. In addition, the Centre holds educational seminars and guest lecturer series. Current Major Areas of Research : • Brain imaging & pain • Chronic pelvic region & genital pain • Genetics of pain • Health innovations in pain management • Human electrophysiological studies on pain • Orofacial pain syndromes • Neuropathic pain • Pediatric pain • Synaptic physiology and plasticity in pain • - Text last updated December 2008


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INSTITUTE: Institute of Medical Science Academic Staff : 563 Participating Departments in the Faculty : The Institute of Medical Science is the graduate unit for all the clinical departments in the Faculty of Medicine (with the exception of Laboratory Medicine & Pathobiology). Its multidisciplinary faculty represents virtually every department in the Faculty of Medicine and includes members from other faculties across the U of T campus. The faculty and students are located on the University campus in the Medical Sciences Building, as well as in the various Hospital Research Institutes that form the University of Toronto Health Sciences Complex. Overall Research Objective : To provide structured education and training of individuals for research careers in traditional biomedical sciences (molecular/cellular and integrative biology) as well as in clinical investigation, health services research and bioethics. This is fulfilled by provision of programmes at the graduate level, and also includes participation in the MD/PhD programme. The emphasis is on the development of research skills backed by broad exposure to medical science and biology that will lead the student to independent scholarship and inquiry. The programmes are directed to both professional and non-professional students, although a special mission of the IMS is the training of clinician scientists. The IMS also participates in the Royal College of Physicians and Surgeons Clinician Investigator Program, and also houses the Masters of Science in Biomedical Communication, the Masters of Health Science in Bioethics, and the Masters of Health Science in Medical Radiation Sciences - Text last updated December 2008


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INSTITUTE: Institute for Work & Health Overall Research Objective : The mission of the Institute for Work & Health is to conduct and share research that protects and improves the health of working people and is valued by policy-makers, workers and workplaces, clinicians, and health & safety professionals. . The Institute is dedicated to the transfer of research results into practice and the exchange of information with our stakeholders. Through the Institute’s association with the University community, and the Institute’s access to workplaces and key sources of data, it has also become an important training ground for graduate students and young investigators. The Institute’s research falls in two broad areas: the primary prevention of work-related injury and illness, and the prevention and management of work disability. The Institute also has an active knowledge transfer and exchange (KTE) program, which implements interactive strategies to transfer research findings to key decision-makers. Current Major Areas of Research : • Working conditions and health • Vulnerable workers • Preventing musculoskeletal disorders (MSDs) • Effective OHS practices • Regulation and incentives • Measuring health and function • Clinical treatment • Return-to-work practices • Compensation and benefits - Text last updated December 2008


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PROGRAM: Cardiovascular Collaborative Program Academic Staff : 85 Graduate Students : 57 Participating Departments and Units : • Anesthesia • Dentistry • Exercise Science • Health Policy, Mgmt & Evaluation • Inst. of Biomaterials & Biomed Eng • Inst. of Medical Science • Laboratory Medicine & Pathobiology • Medical Biophysics • Medicine • Nursing • Pharmaceutical Sciences • Pharmacology • Physiology • Public Health Sciences • Rehabilitation Science • Surgery Overall Research Objective : To develop cooperative and joint graduate teaching and research across departmental boundaries within the Faculty of Medicine and with the Faculties of Dentistry, Nursing, Pharmacy, and Physical Education & Health to enhance the visibility of cardiovascular studies and to facilitate interdisciplinary training and research. Current Major Areas of Research : • Biochemistry of membrane lipids • Cyanotic heart disease • Exercise science • Gender related to cardiovascular studies • Gene expression • Growth factors • Haematology • Heart/lung/kidney • Hypertension/atherosclerosis • Hypertrophy/cardiomyopathy • Infarction/heart failure • Molecular biology • Myocardial protection • Paediatric/fetal development • Periodontal vascularization • Retinal blood flow • Sympathetic nervous system • Translational cardiovascular • Transplantation • Vascular haemodynamics and mineralization - Text last updated December 2008


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Sites : Mount Sinai Hospital, St. Michael’s Hospital, University Health Network and Medical Sciences Building, University of Toronto. Overall Research Objective : To build a Centre of the highest clinical and academic quality for patient care, research and education in the field of immunology and transplantation. The program is founded on the belief that multidisciplinary collaboration and effective communication among team members will support continuous quality improvement. Current Major Areas of Research : Research constitutes a major thrust of the Multi Organ Transplant Program with activities in both basic science of immunology/transplantation as well as the clinical outcomes research. A thematic approach to research has now been adopted with basic science programs in the following areas: • Mechanisms of antigen recognition and rejection • Studies of organ preservation injury • Cellular and molecular mechanisms of organ injury • Identification and characterization of new immunosuppressive agents • Mechanism of tolerance induction • Xenotransplantation • Stem cell technology • In vitro organogenesis • Pathogenesis of infectious disease in the immunocompromised host • Gene therapy • Genomics/proteomics As part of the program we have a CIHR funded Training program in Regenerative Medicine www.regenmedcanada.com (course and funding for fellows and students). For applications e-mail: [email protected] - Text last updated December 2008


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INDUSTRIAL FUNDING SOURCES We would like to acknowledge the sponsorship of our industrial partners. Total grants received: Greater than $1,000,000 Abbott Laboratories Ltd. AstraZeneca Canada Inc. Bayer Inc. Boston Scientific Ltd. Janssen-Ortho Inc. (Canada) Merck Frosst Canada Ltd.

Novartis Pharmaceuticals Canada Inc. Pfizer Canada Inc. Philips Electronics North America Corporation Sanofi-Aventis (Canada) Structural Genomics Consortium

Between $500,000 and $99,999 AMGEN Inc. Aegera Therapeutics Inc Apotex Inc. Bristol-Myers Squibb Pharmaceutical Group (Canada) GlaxoSmithKline Inc. International Nut Council

Johnson & Johnson LKSF Novo Nordisk A/S Pfizer Inc. Roche Diagnostic GmbH Sangamo Biosciences Inc Schering Canada Inc.

Between $200,000 and $499,999 AMGEN Canada Inc. Allergan Inc. Astellas Pharma Canada, Inc. Aviva Canada Inc Baxter Healthcare Corp (Canada) BioMs Technology Corporation Biogen Idec, Inc. Boehringer Ingelheim (Canada) Ltd. Boehringer Ingelheim Pharmaceuticals Inc. Burroughs Wellcome Fund DebioVision Inc. Duchesnay Inc. Eastman Kodak Company Elekta Instrument AB Elekta Ltd. Eli Lilly Canada Inc. GE Healthcare Gemin X Biotechnologies Inc. Genentech Inc. (US) Hoffmann-La Roche Ltd. Insception Biosciences Inc.

Northern Therapeutics Inc. Novartis Pharma AG Ortho Biotech, a Division of Jansenn-Ortho Inc. PAREXEL International Pfizer Inc. Primera Bioscience Research Inc SAIC - Frederick, Inc. Sanofi-Synthelabo Inc. Serono Canada, Inc. Signal Pharmaceuticals, LLC Sun Microsystems of Canada Inc. The Health Technology Exchange The Multiple Myeloma Research Foundation Trillium Therapeutics Inc. Varian Medical Systems, Inc. VistaGen Therapeutics Inc VisualSonics Wyeth-Ayerst Canada Inc. YM BioSciences Inc. YYZ Pharmatech Inc..

Between $100,000 and $199,999 Advanced Neuromodulation Systems Amorfix Life Science Ltd. Aventis Pasteur Ltd. BioMimetic Pharmaceuticals Inc BioTheryX Corp Biorthex Inc. Bristol-Myers Squibb Foundation Inc. Bristol-Myers Squibb Med Imaging CELLutions Biosystems Inc. Celgene Corporation

Edwards Lifesciences GeneOhm Sciences, Canada Inc. Genzyme Corporation Gilead Sciences GlaxoSmithKline Inc. Guidant Canada H. Lundbeck A/S Hoffmann-La Roche Inc. (Canada)?? Idenix Pharmaceuticals, Inc. ImClone Systems Inc.


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Between $100,000 and $199,999 (continued) Johnson & Johnson Services Inc Maquet - Dynamed Medicure, Inc. Medpace Inc. Medtronic of Canada Ltd New England Research Institutes OrbusNeich PPD Development, Inc. Panacis Medical Proteolix Inc.

Pulse Canada RaySearch Medical AB Sandler Program for Asthma Research Sepsis Inc. Smith & Nephew (Canada) St. Jude Medical Canada, Inc. Stryker Canada United Paragon Associates Inc. Wyeth

Less than $100,000 3M Canada ALTANA Pharma Inc. AOP Orphan Pharmaceuticals AG Abbott Laboratories Ltd. Abbott Vascular Inc. Actelion Pharmaceuticals Canada Inc. Actelion Pharmaceuticals Ltd Advance Therapeutics Alcon Inc. Allon Therapeutics Incorporated Almond Board of California Ambrilia Biopharma Inc Annidis Health Systems Corporation Anthera Pharmaceuticals Inc ApoPharma Inc. Arthrex Inc Aryx Therapeutics, Inc. Aspect Medical Systems Inc. Axio Research Company Back2Feet Inc. Bausch & Lomb Inc. Berlex Canada Inc. Bio Syntech Canada Inc. BioDevelops Pharma Entwicklung GmbH BioMarin Pharmaceutical Inc Biosite Incorporated Bristol-Myers Squibb Canada Inc. Burroughs Wellcome Inc. CSL Behring Cascade Therapeutics Inc. Cell Genesys Inc. Centocor, Inc. Cephalon Cevena Bioproducts Inc. Charles River Laboratories International, Inc. ChemoCentryx Inc Cook (Canada) Inc. Cordis Corporation Cyclomedica Australia Pty Ltd. DNP Canada Inc. Danone Institute of Canada Delex Therapies Inc. Dendreon

Domantis Ltd Dompe S.p.A. Eisai Medical Research Inc. Elastin Products Company, Inc. Eli Lilly and Company Encysive Pharmaceuticals Inc Epix Pharmaceuticals, Inc. EvYsio Medical Devices Expression Diagnostics FWF Austrian Science Fund Ferring Pharmaceuticals Inc. Field Metrica Inc. GE Healthcare Gentium S.p.A. GlaxoSmithKline (Canada) GlaxoSmithKline Inc. Glycominds Ltd. H.J. Heinz Company of Canada Ltd. Hoechst Marion Roussel Hogg Robinson Canada Inc. IMBcom Pty Ltd. Institut Rosell, Inc. Intercytex Ltd Isotechnika Inc. J.P. McCarthy Foundation Kellogg Company Kraft Canada Inc. KuDOS Pharmaceuticals Ltd. Life Recovery Systems Luminex Molecular Diagnostics Lundbeck Canada Inc Lundbeck Denmark MDS Health Group Limited MDS Pharma Services MGI Pharma, Inc. Marine Polymer Technologies Med Enclosure LLC MedPharmGene Inc. Medtronic MiniMed Inc Medtronic Sofamor Danek, Inc. Medtronic of Canada Ltd. Memory Pharmaceuticals Corp. MetRegen


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Less than $100,000 (continued) Metabolic Pharmaceutical Ltd MethylGene Inc. MetriGenix Corporation Microvention Inc Micrus Endovascular Corporation Miikana Therapeutics Millennium Pharmaceuticals Inc. Molecular Insight Pharma Inc. NDO Surgical, Inc. NMT Medical Inc NPS Allelix Corporation NPS Pharmaceuticals Inc National Starch and Chemical Company Nicogen Inc. NociPharm Inc NovaLung GmbH Novacea Novartis International AG Novartis Pharmaceuticals Corporation Novartis Pharmaceuticals Corporation Novelis Inc. Octapharma AG Open Biosystems, Inc. Organon Canada Ltd. Osiris Therapeutics Inc Otsuka America Pharmaceutical Inc. PDL BioPharma Pharmaxis Ltd Pharmena North America Inc Procter & Gamble Pharmaceuticals Canada, Inc. Procter & Gamble Pharmaceuticals Canada, Inc. Prometheus Laboraties Inc. Q-Med Scandinavia, Inc.

QLT Inc. REATA Pharmaceuticals Respironics Inc Resverlogix Corporation Rimon Therapeutics Ltd. Roche Products Ltd Sanofi-Synthelabo Inc. Saskatchewan Pulse Growers Servier Canada Inc. Shire BioChem Inc Spiration, Inc St. Jude Medical, Inc. Steba Beheer NV StemCell Tecnologies Inc. Synthes (Canada) Ltd. Synthes Spine Company TAIHO Pharmaceuticals Co., Ltd. Talecris Biotherapeutics, Inc. Taro Pharmaceuticals Inc. Teva Neuroscience, Inc. Thoratec Corporation Tibotec Pharmaceuticals Ltd. Tiense Suikerraffinaderii Services N.V. Transition Therapeutics Inc. Transkaryotic Therapies, Inc. UCB Pharma Vertex Pharmaceuticals Inc. Vion Pharmaceuticals Inc. ViroPharma Inc Viventia Biotech Wilson Cook Medical Corp Z-Tech (Canada) Inc. ZIOPHARM Oncology Inc. Zelos Therapeutics Inc


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Total grants received: Greater than $1,000,000 Argonne National Laboratory Arthritis Society Bill & Melinda Gates Foundation Canada Foundation for Innovation Canada Research Chairs Program Canadian Breast Cancer Foundation Canadian Breast Cancer Research Alliance Canadian Cystic Fibrosis Foundation Canadian Diabetes Association Cancer Care Ontario Crohn's & Colitis Foundation of Canada Fondation Leducq Government of Canada: Canada Research Chairs Government of the United States: National Institute on Alcohol Abuse and Alcoholism Government of the United States: National Institutes of Health (US) Hospital for Sick Children Hospital for Sick Children Foundation John P. Robarts Research Institute Juvenile Diabetes Research Foundation International Leukemia & Lymphoma Society Lincy Foundation McMaster University

Ministry of Health Promotion Ministry of Research and Innnovation (Ontario) Mount Sinai Hospital Multiple Sclerosis Society of Canada Networks of Centres of Excellence: Canadian Stroke Network (CSN) Northwestern University Ontario Cancer Institute Ontario Innovation Trust Ontario Research And Development Challenge Fund Ontario Genomics Institute Ontario Institute for Cancer Research Ontario Mental Health Foundation Ontario Neurotrauma Foundation Physicians' Services Inc. Foundation Private Individuals Province of Ontario St Michael's Hospital The Ontario HIV Treatment Network University Health Network University of Toronto Various companies Various sponsors Workplace Safety and Insurance Board

Between $500,000 and $99,999 Anonymous BioDiscovery Toronto Canadian Health Services Research Foundation Connaught Fund Howard Hughes Medical Institute Kidney Foundation of Canada MaRS Discovery District McGill University McLaughlin Centre for Molecular Medicine

NCE: PrioNet Networks of Centres of Excellence: Canadian Arthritis Network (CAN) Networks of Centres of Excellence: Stem Cell Network (SCN) Ontario Hospital Association Ontario Problem Gambling Research Centre Rick Hansen Foundation

Between $200,000 and $499,999 Alzheimer Society of Canada Alzheimer's Association CIHR Institute of Human Development Canadian Association of Gastroenterology Canadian Blood Services Canadian Foundation for AIDS Research

(CANFAR) Canadian Patient Safety Institute Canadian Tobacco Control Research Initiative Cancer Research Society Inc. Case Western Reserve University City of Toronto

Columbus Children's Research Inst Cystic Fibrosis Foundation (US) Eye Institute of Canada Genome Prairie Inc. George Washington University Government of Canada: Canadian International

Development Agency Government of Canada: International


Government Services Canada


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Between $200,000 and $499,999 (continued) Government of Canada: The Public health

Agency of Canada Government of Ontario: Ministry of Education Government of the United States: Office of Army

Research Hamilton Health Sciences Corporation Krembil Foundation March of Dimes Birth Defects Foundation (U.S.) NCE: Allergy, Genes and Environmental Network National Alliance for Research on Schizophrenia

and Depression Networks of Centres of Excellence: Advanced

Foods and Materials Network (AFMNet) NeuroScience Canada Ontario Centres of Excellence Ontario Thoracic Society Parkinson Foundation of Canada Prostate Cancer Research Foundation of Canada Queen's University

State University of New York/Albany Sunnybrook & Women's College Health Sciences

Centre The Breast Cancer Research Foundation The EJLB Foundation The Foundation Fighting Blindness - Canada The Hospital for Sick Children Psychiatry

Endowment Fund The Michael J. Fox Foundation for Parkinson's

Research The Royal College of Physicians and Surgeons of

Canada The Susan G. Komen Breast Cancer Foundation Toronto Rehabilitation Institute Universite De Montreal University of British Columbia University of California, San Franc University of Ottawa Vanderbilt University

Between $100,000 and $199,999 AOSpine North America American Brain Tumor Association Arthritis Research Centre of Canada Association of Canadian Medical Colleges Bloorview Childrens Hospital Foundation Brain Tumor Society Brigham and Women's Hospital Canadian Institutes of Health research Can. Mental Health Assoc. Canadian Anaesthetists' Society Canadian Association for the Study of the Liver Canadian Association of Radiation Oncologists Canadian Institute for Advanced Research Canadian Institute of Ukrainian Studies Canadian Liver Foundation Canadian Psychiatric Research Foundation Cancer Research Institute (US) Centre for Global Health Research Children's & Women's Health Centre of British

Columbia Children's Heart Foundation Children's Hospital of Eastern Ontario Christopher Reeve Paralysis Foundation Columbia University New York Crohn's & Colitis Foundation of America, Inc. Cure Autism Now Foundation Dartmouth College Do not list - Educ 2004 all subs Douglas Hospital Research Centre Foundation Fighting Blindness Foundation for Informed Medical Decision Making Genomics Ontario Inc Government of Ontario: Ministry of Community,

Family & Children's Services

Human Frontier Science Program Organization J.P. Bickell Foundation Lawson Foundation Massachusetts General Hospital Mount Sinai Hospital Muscular Dystrophy Association (US) Networks of Centres of Excellence: Automobile of

the 21st Century (AUTO 21) Networks of Centres of Excellence: Canadian

Institute for Photonic Innovation (CIPI) Networks of Centres of Excellence: Mathematics


Neuroradiology Education And Research Foundation

Ontario Chiropractic Association Ottawa Health Research Institute Paediatric Consultants Retinoblastoma Solutions Stanford University The Pediatric Brain Tumor Foundation of the

United States The Provincial Centre of Excellence for Child and

Youth Mental Health The Stanley Medical Research Institute US Immunodeficiency Network Universite de Shrebrooke University of Guelph University of Manitoba University of Michigan University of Pennsylvania


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Between $100,000 and $199,999 (continued) University of Pittsburgh University of Rochester

University of Western Ontario Women's College Hospital Foundation York University

Less than $100,000 AIDS Committee of Toronto ALS Society of Canada Adult Polyglucosan Body Disease Research Foundation Albert and Temmy Latner Family Foundation Alberta Heritage Foundation Alex's Lemondate Stand Foundation AllerGen NCE Amalgamated Transit Union MS American Association for Hand Surgery American Association of Neurological Surgeons American College of Surgeons American Foundation for Suicide Prevention American Health Assistance Foundation American Institute for Cancer Research American Physiological Society American Urological Association Foundation Amyotrophic Lateral Sclerosis Association (US) Anesthesia Patient Safety Foundation Arthritis Foundation Associated Medical Services, Inc. Association of Hemophilia Clinic Directors of Canada B.r.a.i.n. Child BC Ministry of Public Safety Banting & Best Diabetes Centre Banting Research Foundation Barbara Keenan Foundation Beatty Benaroya Research Institute at Virginia Mason Biotechnology and Biological Sciences Research Institute Brain Tumor Foundation of Canada C17 research Network CIHR : Institute of Infection CIHR Institute: ICR CIHR: Institute of Circulatory and Respiratory Health CIHR: Institute of Musculoskeletal Canadian Allergy, Asthma and Immunology Foundation Canadian Association of Emergency Physicians Canadian Association of General Surgeons Canadian Bureau for International Education Canadian Council on Learning Canadian Dermatology Foundation Canadian Foundation for Dietetic Research Canadian Gene Cure Foundation Canadian HIV Trials Network Canadian Heart Research Centre Canadian Hypertension Society

Canadian Intensive Care Foundation Canadian Lung Association Canadian Medical Protective Association Canadian Orthopaedic Association Canadian Orthopaedic Foundation Canadian Paediatric Society Canadian Paraplegic Association Canadian Society for Clinical Nutrition Canadian Urologic Oncology Group Canadian Urological Association Canadian Urology Research Consortium Centre Hospitalier de L'Universite de Montreal Centre for Addiction and Mental Health Centre of Research Expertise in Improved Disability Outcomes Children's Hospital Boston Children's Hospital of Philadelphia Children's Memorial Research Center Christopher and Dana Reeve Foundation Cincinnati Children's Hospital Medical Center Clarkson University College of American Pathologists Foundation Colon Cancer Canada Craig H. Neilsen Foundation CureSearch Children's Oncology Group Dairy Farmers of Canada Dalhousie University Dana-Farber Cancer Institute Deptartment. of Health and Ageing, Government of Australia Duke University Dystonia Medical Research Foundation E.A. Baker Foundation of the CNIB European Hematology Association (Netherlands) Fight for Sight Foundation for Digestive Health and Nutrition (AGA) Four Counties Addiction Services Team Fowler Kennedy Sport Medicine Clinic Fragile X Research Foundation of Canada Gebert-Ruf Foundation General Paediatrics Associates Glaucoma Research Society Government of British Columbia: Ministry of Health Government of Canada: Canada Mortgage and Housing Corporation Government of Canada: Canadian Heritage Government of Canada: Statistics Canada


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Less than $100,000 (continued) Government of Ontario: Ministry of Agriculture and Rural Affairs Government of Ontario: Ministry of Energy Government of Ontario: Ministry of the Attorney General Government of Ontario: Ministry of the Environment Government of the United States: Department of Agriculture Government of the United States: Department of Veterans Affairs Harvard University Head and Neck Cancer Foundation Heart Failure Society of America Henrietta Banting Memorial Fund Henry White Kinnear Foundation Higher Education Commission of Pakistan ICON IWK Health Centre Imperial College London Inner City Health Associates Inst. for Clinical Eval. Sciences Institute for Work & Health Institute of Environmental Science and Research Limited International Institute for Research in Paraplegia International Society of Blood Transfusion Foundation International Society of Heart & Lung Transplantation Jewish Gen Hosp, McGill-CIHR Lakeridge Health London Health Sciences Centre Lupus Canada Lymphoma Foundation Canada Macula Vision Research Foundation Maternal and Child Health Bureau Mayo Medical School McEwen Centre for Regenerative Medicine Medical Council of Canada Medical Univ of South Carolina Mesothelioma Foundation Montana State University Montreal Heart Institute Mount Sinai School of Medicine Multiple Myeloma Research Consortium Muscular Dystrophy Association of Canada National Brain Tumor Foundation National Parkinson Foundation Inc. Natl Net Environ and Women's Health Networks of Centres of Excellence: Canadian Language & Literacy Research Network (CLLRNet) Networks of Centres of Excellence: Canadian Network for Vaccines and Immunotherapeutics

Neurosurgery Research and Education Foundation Neutropenia Support Association Inc New Hope Foundation North American Society For Pediatric Gastroenterology, Hepatology and Nutrition Northeast Mental Health Centre Obsessive Compulsive Foundation Ontario Association of Medical Laboratories Ontario Cancer Biomarker Network Ontario Clinical Oncology Group Ontario Federation Cerebral Palsy Ontario Lung Association Ontario Lupus Association Ontario Ministry of Community Safety and Correctional Services Ontario Public Health Association Ontario Respiratory Care Society Ontario Tobacco Research Unit Org of Teratology Info Specialists Ortho Trauma Association Otsuka Mayland Research Institute PREMIER'S RESEARCH EXCELLENCE AWARD Physiotherapy Foundation of Canada Prostate Cancer Research Foundation Providence Health Care Society Quinte Health Care Corporation ResMed Foundation Rett Syndrome Research Foundation Rheuminations Inc Royal Society of Canada Royal Victoria Hosp of Barrie Foundation Royal Women's Hospital Ryerson University Savoy Foundation Scleroderma Society Of Ontario Shriners Hospitals for Children - Canada Society of Cardiovascular Anaesthesiologists Society of Obstetricians and Gynaecologists of Canada South Africa Medical Research Council St Joseph Health Centre St Joseph's Health Care St. Baldrick's Foundation Sunray Diabetes Foundation Thalassemia Foundation of Canada The American Society of Clinical Oncology The American Society of Nephrology The Atkinson Charitable Foundation The Canadian Chiropractic Research Foundation The Dr. Charles H. Best Foundation The Drummond Foundation The Francis Families Foundation The Gorbachev Foundation of North America The Hearing Foundation of Canada


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Less than $100,000 (continued) The James H. Cummings Foundation Inc. The James S. McDonnell Foundation The Jarislowsky Foundation The Leukemia & Lymphoma Society of Canada The Lustgarten Foundation for Pancreatic Cancer Research The Montreal General Hospital The National Multiple Sclerosis Society The National Surgical Adjuvant Breast and Bowel Project (NSABP) The Ontario Council on Gradual Studies The Ottawa Hospital The Pediatric Oncology Group of Ontario The Princess Margaret Hospital Foundation The Sanfilippo Children's Research Foundation The Scottish Rite Charitable Foundation The Tema Conter Memorial Trust The Workers' Compensation Board of British Columbia Thrasher Research Fund Toronto Centre for Antimicrobial Research & Evaluation Toronto Transit Commission Tourette Syndrome Association (US) Town of Oakville

United Mitochondrial Disease Founda Univ of Ottawa Heart Institute University of Colorado University of Dundee University of Florida University of Maryland University of Medicine and Dentistr University of Miami University of Missouri University of North Carolina (CH) University of P.E.I. University of Texas at Dallas University of Victoria University of Washington University of Waterloo Unknown sponsor Various Sponsors Various Sponsors Washington University St Louis Wayne State University Wellesley Central Health Corporation West Park Hospital Foundation WorkSafe BC Workers Compnesation Board of Manitoba World Bank Yale University


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Based on RIS data snapshot : 16 December 2009, 0930hrs

Version 1: February 8, 2010

PRODUCED BY: Office of the Vice Dean, Research and International Relations Faculty of Medicine University of Toronto http://www.medresearch.utoronto.ca/ Rooms 2331 - 2340 1 King’s College Circle Toronto, Ontario M5S 1A8 CANADA Contact person: GJ Baylon, MD Coordinator, Research Information (416) 978 – 8339 [email protected]







Source .................................................................................................................................. 19


Departmental Synopses Notes to Faculty of Medicine Departments...................................................................................... 20 Summary of Department research funding and personnel ............................................................. 21 Anesthesia........................................................................................................................................ 22 Banting and Best Department of Medical Research ....................................................................... 23 Biochemistry ..................................................................................................................................... 24 Family and Community Medicine..................................................................................................... 25 Health Policy, Management and Evaluation.................................................................................... 26 Immunology...................................................................................................................................... 27 Inst. of Biomaterials & Biomedical Engineering............................................................................... 28 Laboratory Medicine and Pathobiology ........................................................................................... 29 Medical Biophysics........................................................................................................................... 30 Molecular Genetics (formerly Medical Genetics & Microbiology).................................................... 31 Medical Imaging ............................................................................................................................... 32 Medicine ........................................................................................................................................... 33 Nutritional Sciences.......................................................................................................................... 34 Obstetrics and Gynaecology............................................................................................................ 35 Occupational Science & Occupational Therapy. ............................................................................. 36 Ophthalmology and Vision Sciences ............................................................................................... 37 Otolaryngology – Head and Neck Surgery ...................................................................................... 38 Paediatrics........................................................................................................................................ 39 Pharmacology and Toxicology......................................................................................................... 40 Physical Therapy.............................................................................................................................. 41 Physiology ........................................................................................................................................ 42 Psychiatry ......................................................................................................................................... 43 Public Health (Dalla Lana School of) ............................................................................................... 44 Radiation Oncology.......................................................................................................................... 45 Speech-Language Pathology........................................................................................................... 46 Surgery ............................................................................................................................................. 47 Affiliated Teaching Hospital Synopses Notes to the Affiliated Teaching Hospitals ....................................................................................... 48 Summary of Hospital research funding and personnel ................................................................... 49 Baycrest Centre for Geriatric Care................................................................................................... 50 Bloorview Kid’s Rehab .................................................................................................................... 51 Centre for Addiction and Mental Health........................................................................................... 52 The Hospital for Sick Children.......................................................................................................... 53 Mount Sinai Hospital ........................................................................................................................ 54 St. Michael’s Hospital ....................................................................................................................... 55


Sunnybrook Health Sciences Centre, Orthopaedic & Arthritic Site................................................. 56 Sunnybrook Health Sciences Centre, Sunnybrook Site.................................................................. 57 Toronto Rehabilitation Institute ........................................................................................................ 58 University Health Network................................................................................................................ 59 Women’s College Hospital ............................................................................................................... 60 Intra/Extradepartmental Centre, Group, Institute, and Program Synopses Notes to Summary of Intra/Extradepartmental Units....................................................................... 61 Banting and Best Diabetes Centre................................................................................................... 62 Joint Centre for Bioethics ................................................................................................................. 63 Donnelly Centre for Cellular & Biomolecular Research................................................................... 64 Clinical Science Division .................................................................................................................. 65 The Wilson Centre for Research in Education ................................................................................ 66 Gage Occupational & Environmental Health Unit ........................................................................... 67 Centre for Health Promotion ............................................................................................................ 68 Centre for International Health ........................................................................................................ 69 R.S. McLaughlin Centre for Molecular Medicine ............................................................................. 70 Centre for Research in Neurodegenerative Diseases..................................................................... 71 Industrial Funding Sources .............................................................................................................. 72 Other Funding Sources .................................................................................................................... 75


IV

MESSAGE FROM THE VICE DEAN, RESEARCH AND INTERNATIONAL RELATIONS This is the 23rd edition of the Synopsis. I am pleased to serve as Interin Vice Dean, Research and International Relations. I am joined in this endeavor by my colleagues George Fantus, Associate Dean, Research, and Mingyao Liu, Director for International Research Relations. I wish to acknowledge the excellent contributions of GJ Baylon, Liz Fragnelli and Heather Drouillard who collect and maintain our funding database and produce the reports for this very important document.

This synopsis highlights research funding and activities for the period 2008/09 by Faculty of Medicine researchers situated on campus and at the research institutes of the following 10 fully affiliated hospitals: Baycrest Centre for Geriatric Care, Bloorview Kids Rehab, The Centre for Addiction and Mental Health, The Hospital for Sick Children, Mount Sinai Hospital, St. Michael's Hospital, Sunnybrook Health Science Centre, Toronto Rehabilitation Institute, University Health Network and Women’s College Hospital.

Creation of the CIHR, as well as establishment of federal funding programs including the Canada Foundation for Innovation, Canada Research Chairs, and Genome Canada; and at the provincial level, establishment of the Ontario Research Fund and the Early Researcher Awards over the past 9 years have dramatically improved the research climate in Canada and Ontario (see Figure 1). The health research community in Toronto has benefited tremendously from infrastructure and salary award funding from these initiatives. The recent “flat-lining” of the CIHR operating budget continues to be a worrisome development. What we need is balanced and stable funding commitments (operating, infrastructure and career awards) at both provincial and federal levels to fund the full costs of research. This includes overhead costs which are essential to maintain the expensive infrastructure that is required for high quality research. We will strongly advocate for this once again over the coming year.

Some Highlights of 2008 - 2009

• CIHR New Investigator Awards

Dennis Ko Department of Medicine Laurie Marras Department of Medicine Jason Moffat Banting and Best Department of Medical Research Damon Scales Department of Medicine


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• New Canada Research Chairs

Tier 2 John Cunningham Dalla Lana School of Public Health Robin Green Department of Psychiatry Jeff Myer Department of Psychiatry Kenichi Okamoto Department of Molecular Genetics Kaveh Shojania Department of Medicine Renewed Canada Research Chairs

Tier 1 David Bazett-Jones Department of Biochemistry Claire Bombardier Department of Medicine David Clarke Department of Medicine Alejandro Jadad Department of Anesthesia Kevin Kain Department of Medicine Robert Kerbel Department of Medical Biophysics Stephen Lye Department of Obstetrics and Gynecology Pamela Ohashi Department of Medical Biophysics Emil Pai Department of Biochemistry Donald Redelmeier Department of Medicine Tier 2 Thomas Chau Inst. of Biomaterials & Biomedical Engineering Peter Cheung Department of Medical Biophysics Paul Frankland Department of Physiology Scott Heximer Department of Physiology Sheena Josselyn Department of Physiology Beverly Orser Department of Anesthesia Janice Robertson Department of Lab Medicine and Pathobiology Pascal Van Lieshout Department of Speech-Language Pathology Allen Volchuck Department of Biochemistry


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• MRI Early Researcher Awards


In 2008/09, the following were recipients of this award:

Tom Chau Inst. of Biomaterials & Biomedical Engineering James R. Carlyle Department of Immunology Christopher S. Parshuram Department of Paediatrics Mona R. Loufty Department of Medicine Catriona M. Steele Department of Speech-Language Pathology Peter Cheung Department of Medical Biophysics Douglas Lee Department of Medicine


Avrun I. Gotlieb, MDCM, FRCPC Interim Vice Dean, Research and International Relations February 12, 2010


VII

SYNOPSIS OF RESEARCH ACTIVITIES 2008 – 2009 The Synopsis of Research Activities in the Faculty of Medicine is published annually by the Faculty Research Office. This, the 23rd edition, covers the period from April 1, 2008 to March 31, 2009. It presents data and analysis of direct research funding and awards received by faculty members in the Faculty of Medicine for this period. These include operating grants, equipment and maintenance grants, and personnel awards to principal investigators and trainees (graduate students, postdoctoral and clinical fellows), and other research related special grants. Data for the previous four years are presented for comparison. In addition, funding received (as opposed to the total project award) during this period from the Canada Foundation for Innovation (CFI) and from the Ontario Innovation Trust (OIT) or ORF are reported in a separate category. Overhead received and indirect costs such as building maintenance, library and computing services, administrative services, faculty salaries, and basic equipment cost and maintenance are not included. Funding received is segregated by departments and by geographic locations: on campus or in the affiliated hospitals. Guidelines defining research funding and its assignment are described in the Terms of Reference on page XIII. The Faculty Research Office works closely with all Faculty departments, the affiliated hospitals and hospital research institutes to ensure the data reported are as complete and accurate as possible.

INTRODUCTION The Faculty of Medicine at the University of Toronto is the largest medical faculty in Canada and ranks among the top in North America. Currently it admits 224 students to its first year of a 4-year undergraduate medical program. At the post-graduate level, the Faculty offers 75 specialty training programs leading to certification by the Royal College of Physicians and Surgeons of Canada, or by the College of Family Physicians of Canada. In addition to its primary responsibility in medical education, the Faculty participates heavily in the education of undergraduates in the Faculty of Arts and Science and in other health science faculties. To complete its educational role, members of the Faculty actively supervise a large number of graduate students enrolled in M.Sc. and Ph.D. programs, and organize and teach graduate courses. There are 26 departments in the Faculty including 9 departments in basic science (including the Institute of Biomaterials and Biomedical Engineering), 15 in clinical science (including Physical Therapy, Occupational Therapy and Speech-Language Pathology) and two in community health. In addition, there are 22 extra-departmental units (EDUs) organized as either a Centre, Division, Institute, Group, Unit, or Program. These units are inter-departmental in their structure and engage in multidisciplinary research and education. The Faculty has more than 5,000 faculty members holding a range of academic positions that are fully or partly salaried on University budget, or are non-salaried. The scope of research activity in the Faculty of Medicine is very broad, ranging from basic science, clinical investigation to community health and the rehabilitation sciences. There is a


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research continuum from the curiosity-driven to the applied. At one end are studies at the molecular and gene level to create fundamental knowledge crucial to our understanding of the normal and the disease biological process, leading to advancements in diagnosis, more effective prevention and treatment of disease. At the other end are research activities on the promotion of health and wellness, the improvement of rehabilitation, the prevention of disability and the development of policy on health and health administration. The Synopsis measures this large research enterprise in terms of its annual research revenues.

RESEARCH FUNDING: 2008 – 2009 Researchers in the Faculty of Medicine receive research funding from national, provincial and foreign funding agencies. These include the Canadian Institutes for Health Research (CIHR), Natural Sciences and Engineering Research Council (NSERC), Social Sciences and Humanities Research Council (SSHRC), Health Canada (HLTH CAN), and the Ontario Ministry of Health (MOH), and disease-oriented agencies such as the National Cancer Institute of Canada (NCIC), the Heart and Stroke Foundation of Ontario/Canada (HSFO/C), the National Institutes of Health, the Howard Hughes Medical Institute of the United States, and the US Department of Defense (Cancer Programs). In 2008/09, the Faculty received a total of $626 million in research funds from all sources, an increase of 5 % from the previous year. Research grants accounted for about $485 million of this total, while personnel awards totaled $82 million.. CIHR continued to be the single major source of funding accounting for about $149 million of the total, up from $145 million in the previous year. Other major single sources of funding were NCIC ($17 million) and the Ontario Ministry of Health ($17 million), with slight decreases and increases respectively from the previous year. Funding from Health Canada increased to $2.3 million from $1.6 million. Funding from the diverse category of other sources (see pp 84) which includes disease-oriented agencies and specific institutional awards totaled $314 million. Funding from industry accounted for $47 million. Tables 4 shows the "on campus" and "affiliated teaching hospital" geographical assignment of total research revenue. Assignment to hospital sites was about $436 million, accounting for 70 % of the total. Table 4 also presents an analysis of the geographical distribution of grants and awards from the various funding agencies. During this period, investigators located in the affiliated teaching hospitals and on campus received $107 million and $42 million respectively from CIHR. Thus as a group, researchers located on campus maintained their share of about 26% of the total CIHR funding. Funding from sources identified as "Other" to campus-based investigators decreased by $3 million to about $70 million, while there was a decrease of about $1 million to hospital-based researchers to $238 million.


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GOVERNMENT RESEARCH INFRASTRUCTURE PROGRAMS Canada Foundation for Innovation (CFI) began its infrastructure funding programs during 1999. At time of writing, CFI has awarded a total of 89 institutional projects from the Faculty and its affiliated hospitals. These projects were based on the following five research platforms identified by the Faculty in consultation with the departments and hospital research institutes:


About $52 million has been received from CFI and OIT, for 2008-09, up from the $12 million 2007/ 08. This does not include CFI New Opportunities awards, which are included in the total research funding.

COMPARISON TO PREVIOUS YEARS Table 2A shows the annual research funding in current dollars by department from 2004 to 2009. The annual changes are analyzed as an average over a 3-year period. Table 2B shows the same data in 2004 constant dollars. All sectors have continued to grow. Overall, total research funding in current dollars over the 5-year period increased by $80M, or $75M in constant dollars since 2004. Figure 1 shows that in the 16-year period beginning 1987, research revenue of the Faculty initially followed a linear rate of growth at an average of of 11%/year over 13 years in spite of a slight hiatus from 1993 to 1995, a period of federal budget constraint on research. In 2000 the rate of growth increased dramatically and is almost linear rate of growth at an average of 15%/year over 8 years in current dollars or 3.6%/year in constant dollars. Table 5 presents the research funding by source in this and the previous seven years. Funding from Canadian federal sources showed an increase from $129 M in 2001/2002 to $223 M in 2008/09, for 39% of the Faculty total research revenue. Research revenue from provincial sources has dropped slightly to 12% compared to 15% in 2001/2002. Funding from not-for-profit organizations accounts for about 21% of the total. Industrial funding remained constant at 8% of the total from the previous year. (Figure 1 and Table 5).

RESEARCH AWARDS The total number of research grants in 2008/09 was 4,139, not significantly changed from the previous year of 4,121 (Table 6). The number of research personnel awards to principal investigators has decreased from 175 to 173


X


Research Fellows Postdoctoral fellows and clinical research fellows are major contributors to the research enterprise of the Faculty. Tables 7 and 8 summarize the distribution of postdoctoral fellows and clinical research fellows in the Faculty. The number of postdoctoral and clinical research fellows has increased by 18% from 2007/08 to 1432.

Graduate Student Funding In 2008/09 the total graduate student funding (awards and stipends) was $48 M, and of this, $26 M were awards, while $22 M were stipends, as shown in Table 10. The award and stipend distribution by the Graduate unit is given in Table 11. The breakdown by administrative site is provided in Table 12. The total funding supports about 2000 graduate students

Research Space The total campus research space of the Faculty of Medicine currently is 31,607 sq m (Table 9). On-campus research and research-support space in the Faculty has changed dramatically over the past few years. For more than thirty-five years, the Banting Institute, Best Institute, FitzGerald Building, Medical Sciences Building, McMurrich Building, Tanz Neuroscience Building, Gage Research Institute, together with buildings at 1 Spadina, 256 McCaul Street, and 82 and 88 College Street have housed the Faculty of Medicine. This changed eight years ago with the


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purchase and subsequent renovation of a 10-storey building (6,700 nasm) at 500 University Avenue. This building now houses the Departments of Physical Therapy, Occupational Science and Occupational Therapy, Speech-Language Pathology, as well as the Offices of the Vice Deans of Continuing Education & Professional Development and Postgraduate Medicine. The construction of the $96M Donnelly Centre for Cellular and Biomolecular Research (CCBR) was completed in 2005. The CCBR (10,000 nasm) has 30 faculty and ultimately will house 35 principal investigators and more than 500 research staff. Finally, five years ago the University purchased the former Board of Education building (155 College Street), which has been extensively renovated and now houses three Faculty departments/schools: Dalla Lana School of Public Health; Health Policy, Management and Evaluation; and Family and Community Medicine. The McMurrich Building, previously home to PHS and HPME, has been returned to the University for other purposes. The MSB has undergone some renovations to provide improved research, teaching and support space.


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appointment.










an RIS ‘by-Location’ Report download (data snapshot) initiated at 0930 hrs of December 16, 2009.





AwardsBASICBBDMR 29,828 7,356 199 838 0 0 96 0 2,153 19,185 160Biochemistry 13,623 5,150 631 945 0 0 302 0 248 6,348 219Biomat & Biomed Eng 3,697 1,092 118 0 0 0 70 0 165 2,251 57Immunology 14,664 4,087 69 505 0 0 297 0 485 9,221 150Medical Biophysics 51,548 9,262 567 4,414 0 727 547 0 2,383 33,647 466Medical Genetics & Microbiology 67,661 16,319 777 4,520 0 500 15 0 3,010 42,520 569Nutritional Sciences 5,022 1,575 474 0 0 0 0 0 235 2,738 120Pharmacology 5,169 1,752 84 0 0 0 156 0 670 2,507 93Physiology 15,503 6,745 558 0 0 0 1,411 0 207 6,583 373

SUB-TOTAL 206,715 53,338 3,477 11,222 0 1,227 2,894 0 9,556 125,000 2,207COMMUNITY HEALTHHealth Policy, Mgmt & Eval 7,334 1,905 0 0 57 2,341 69 30 0 2,931 149Public Health Sciences 30,025 9,423 180 0 903 3,232 194 392 814 14,888 328

SUB-TOTAL 37,359 11,328 180 0 960 5,573 263 422 814 17,819 477CLINICALAnesthesia 4,611 1,073 65 0 0 22 0 0 1,044 2,407 93Family & Community Medicine 5,557 547 0 43 210 1,851 0 0 49 2,858 63Lab. Medicine & Pathobiology 28,674 6,564 678 1,543 0 513 2,190 0 3,587 13,600 427Medical Imaging 6,338 563 64 71 0 1,027 21 0 259 4,334 64Medicine 124,146 29,732 216 1,859 1,093 2,079 7,841 57 20,105 61,165 1,571Obstetrics & Gynaecology 7,437 3,881 37 0 3 92 32 0 59 3,334 106Occupational Therapy 2,899 363 76 0 0 410 44 47 0 1,958 223Ophthalmology And Vision Sci 4,445 996 0 375 0 0 0 0 441 2,634 80Otolaryngology 631 203 0 0 0 0 0 0 33 395 16Paediatrics 55,639 20,612 126 771 76 552 801 47 3,083 29,570 538Physical Therapy 3,362 768 136 0 0 182 363 37 0 1,876 246Psychiatry 22,330 8,198 116 58 0 165 399 813 3,763 8,819 365Radiation Oncology 9,738 788 50 464 0 60 0 0 1,953 6,422 185Speech-Language Pathology 2,278 467 30 0 0 0 92 113 75 1,502 154Surgery 33,376 7,451 273 916 0 486 1,806 0 2,519 19,924 535

SUB-TOTAL 311,461 82,206 1,867 6,100 1,382 7,439 13,589 1,114 36,970 160,798 4,666Other 1 10,515 2,187 326 0 0 3,000 0 197 137 4,669 317


GRAND TOTAL 4 626,339 (x $1000) 7,765


4 Excludes a total of $_________ from the Federal Indirect Costs Program awarded to affiliate hospitals.




Synopsis of R


edicine: 2008-2009

1

DEPARTMENT Hospital Campus Hospital Campus Hospital Campus Hospital Campus Hospital CampusBASICBBDMR 2,482 44,760 1,561 21,123 2,845 21,602 2,758 39,388 2,683 27,144Biochemistry 16,274 4,479 9,321 4,904 8,503 6,420 10,663 5,695 7,926 5,698Biomat & Biomed Eng 987 1,170 1,663 914 1,227 1,107 1,013 1,316 1,139 2,558Immunology 9,154 1,591 9,929 3,429 11,218 2,529 11,777 2,542 11,422 3,241Medical Biophysics 72,793 1,629 64,082 1,121 65,944 3,105 53,374 1,501 49,431 2,117Medical Genetics & Microbiology 37,154 8,555 49,934 7,999 53,848 11,017 48,593 12,042 54,579 13,082Nutritional Sciences 1,607 3,410 1,634 3,184 1,987 4,744 1,588 3,968 772 4,251Pharmacology 1,339 2,717 1,079 4,923 1,665 6,104 1,801 2,830 2,153 3,016Physiology 4,714 6,561 5,567 7,415 6,228 9,294 7,072 7,503 6,972 8,532


SUB-TOTAL 15,735 16,758 18,980 13,776 18,236 15,279 24,233 14,764 22,348 15,010CLINICALAnesthesia 3,561 700 3,343 472 3,450 524 4,846 502 3,982 630Family & Community Medicine 4,010 785 4,722 510 8,033 691 6,702 313 3,690 1,867Lab. Medicine & Pathobiology 17,707 7,691 17,483 6,715 19,357 6,675 22,095 6,355 21,626 7,048Medical Imaging 7,325 15 9,514 179 9,124 507 6,073 268 5,969 370Medicine 88,744 16,133 88,088 15,514 86,565 21,270 97,690 17,558 105,345 18,801Obstetrics & Gynaecology 7,123 1 8,056 26 7,848 129 8,067 81 7,360 76Occupational Therapy 604 813 689 976 1,176 1,613 792 1,166 1,113 1,786Ophthalmology And Vision Sci 3,448 1,090 3,593 1,324 3,859 1,668 3,294 1,349 4,173 272Otolaryngology 426 21 445 14 888 51 543 42 600 30Paediatrics 20,562 201 27,665 190 40,616 523 46,433 408 54,520 1,119Physical Therapy 1,321 767 1,042 1,484 1,318 1,311 1,483 1,245 1,382 1,980Psychiatry 23,722 1,437 21,666 1,019 23,264 1,950 21,657 611 21,487 843Radiation Oncology 7,269 28 8,154 75 11,590 254 13,210 195 9,254 484Speech-Language Pathology 433 1,066 299 1,351 267 1,189 328 1,168 604 1,674Surgery 24,686 885 37,382 1,560 32,540 1,801 33,668 1,476 31,405 1,971

SUB-TOTAL 210,941 31,633 232,141 31,409 249,895 40,156 266,881 32,737 272,510 38,951Other 1 9,868 1,786 12,063 2,331 6,562 5,014 7,920 4,961 4,569 5,946

TOTAL 383,048 125,049 407,954 102,528 428,158 126,371 437,673 129,247 436,504 129,546CFI/OIT 2 19,187 18,141 18,462 4,900 28,198 2,001 10,495 1,953 46,090 6,004Indirect Costs 3 1,160 6,559 1,278 11,805 1,621 12,946 1,638 6,458 1,737

GRAND TOTAL 402,235 143,190 426,416 107,428 456,356 128,372 448,168 131,200 489,052 137,287FISCAL YEAR TOTAL




FY 2004-05 FY 2005-06 FY 2006-07 FY 2007-08 FY 2008-09


626,340593,952

Synopsis of R


edicine: 2008-2009

2

Department All Locations Campus Baycrest Bloorview CAMH HSC MSH SMH SHSC TRI UHN WCH OtherBASICBBDMR 29,828 27,144 0 0 0 1,003 0 0 0 0 1,680 0 0Biochemistry 13,623 5,698 0 0 0 7,496 0 0 0 0 325 0 104Biomat & Biomed Eng 3,697 2,558 0 714 0 0 0 0 135 280 10 0 0Immunology 14,664 3,241 0 0 0 7,004 672 0 2,453 0 1,294 0 0Medical Biophysics 51,548 2,117 553 0 0 3,001 1,320 0 11,113 0 33,443 0 0Medical Genetics & Microbiology 67,661 13,082 0 0 0 19,817 30,664 0 0 0 4,098 0 0Nutritional Sciences 5,022 4,251 30 0 0 69 5 668 0 0 0 0 0Pharmacology 5,169 3,016 0 0 554 0 0 907 692 0 0 0 0Physiology 15,503 8,532 0 0 0 3,952 67 592 3 0 2,358 0 0

SUB-TOTAL 206,716 69,639 583 714 554 42,343 32,728 2,167 14,395 280 43,208 0 104COMMUNITY HEALTHHealth Policy, Mgmt & Eval 7,334 5,562 0 0 399 475 0 501 165 8 224 0 0Public Health Sciences 30,025 9,448 0 0 7,681 2,290 1,723 4,000 1,092 293 1,796 1,224 478

SUB-TOTAL 37,359 15,010 0 0 8,080 2,765 1,723 4,500 1,257 300 2,020 1,224 478CLINICALAnesthesia 4,611 630 0 0 0 445 504 1,497 507 0 1,029 0 0Family & Community Medicine 5,557 1,867 0 0 2,056 11 327 807 263 0 0 10 215Lab. Medicine & Pathobiology 28,674 7,048 0 0 0 4,810 6,705 1,256 2,565 0 6,291 0 0Medical Imaging 6,338 370 0 0 0 680 67 76 5,075 0 71 0 0Medicine 124,146 18,801 1,960 0 169 137 15,669 23,545 20,696 3,323 38,238 1,578 31Obstetrics & Gynaecology 7,437 76 0 0 0 37 6,136 124 1,054 0 0 10 0Occupational Therapy 2,899 1,786 67 95 0 0 0 419 0 531 0 0 0Ophthalmology And Vision Sci 4,445 272 0 0 0 467 0 791 0 0 2,916 0 0Otolaryngology 631 30 10 0 0 509 0 60 21 0 0 0 0Paediatrics 55,639 1,119 0 2,143 0 38,210 79 44 1,639 0 12,404 2 0Physical Therapy 3,362 1,980 137 200 0 0 0 127 0 420 276 156 67Psychiatry 22,330 843 832 0 14,074 1,585 206 827 1,010 444 2,397 55 58Radiation Oncology 9,738 484 0 0 0 0 0 0 2,214 0 7,040 0 0Speech-Language Pathology 2,278 1,674 82 123 0 0 0 0 4 396 0 0 0Surgery 33,376 1,971 0 0 0 8,196 2,894 3,796 3,676 2,374 10,434 35 0

SUB-TOTAL 311,461 38,949 3,088 2,561 16,300 55,088 32,586 33,368 38,723 7,488 81,095 1,846 371Other 10,515 5,946 0 0 40 1,255 0 134 0 3,015 100 0 25CFI/OIT 52,094 6,004 0 0 835 5,313 10,131 256 1,132 0 28,423 0 0Indirect Costs 1 8,195 1,737 341 0 1,263 201 357 1,085 0 1,067 2,144 0 0

GRAND TOTAL 626,340 137,286 3,671 3,275 25,809 106,763 77,169 40,425 55,507 11,083 154,846 3,070 9791 Excludes a total of $18,440,070 from the Federal Indirect Costs Program awarded to affiliate hospitals.




Synopsis of R


edicine: 2008-2009

3


# of Awards

Baycrest Centre for Geriatric Care 3,671 1,602 56 0 0 4 1,245 0 149 615 47Bloorview Kid's Rehab 3,275 15 0 0 0 0 0 0 145 3,115 42Centre for Addiction and Mental Health 24,974 6,582 42 0 627 1,657 302 487 3,280 11,996 231Hospital for Sick Children 101,450 24,522 659 2,919 76 830 2,482 99 3,887 65,975 1,091Mount Sinai Hospital 66,916 14,530 291 3,546 3 341 413 0 6,882 40,910 601St. Michael's Hospital 40,290 8,247 59 6 1,251 2,771 1,334 19 5,995 20,609 784SHSC

Sunnybrook site 54,366 11,716 184 2,399 0 2,323 4,239 35 8,176 25,295 386 Orthopaedic & Arthritic site 10 0 0 0 0 0 0 0 0 10 1Toronto Rehabilitation Institute 11,083 998 53 0 0 3,444 139 0 2,275 4,174 93University Health Network 126,423 37,412 521 5,518 0 1,990 4,285 33 13,021 63,642 1,159Women's College Hospital 3,070 1,298 0 35 0 146 0 0 14 1,577 50Other Hospitals 1 506 218 0 0 135 0 0 0 0 152 11

SUB-TOTAL 436,033 107,140 1,865 14,423 2,092 13,506 14,439 673 43,824 238,070 4,496Other Locations 2 473 138 0 0 0 0 0 0 0 335 10UofT Campus 129,545 41,781 3,984 2,897 250 3,733 2,308 1,059 3,652 69,880 3,161


GRAND TOTAL 626,340 (x $1000) 7,765

1 Research at non-affilitaed hospitals.2 Research at other locations other than UofT Campus and other hospitals.3 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Health Sciences Centre, University of Toronto and the University Health Network.




Synopsis of R


edicine: 2008-2009

4

DEPARTMENT FY 2004-05 FY 2005-06 FY 2006-07 FY 2007-08 FY 2008-09 2004-2007 2005-2008 2006-2009BASICAnatomy and Cell Biology 1 N/A N/A N/A N/A N/A N/A N/A N/ABBDMR 47,242 22,684 24,446 42,146 29,828 -22.1 40.1 21.6Biochemistry 20,754 14,224 14,923 16,358 13,623 -13.3 7.3 -3.6Biomat & Biomed Eng 2,157 2,578 2,334 2,330 3,697 5.0 -4.8 29.3Immunology 10,745 13,357 13,747 14,319 14,664 13.6 3.5 3.3Medical Biophysics 74,422 65,203 69,049 54,875 51,548 -3.2 -7.3 -13.3Medical Genetics & Microbiology 45,709 57,933 64,865 60,635 67,661 19.4 2.7 2.5Nutritional Sciences 5,016 4,819 6,731 5,556 5,022 17.9 11.1 -13.5Pharmacology 4,056 6,003 7,769 4,631 5,169 38.7 -5.5 -14.4Physiology 11,275 12,982 15,521 14,575 15,503 17.4 6.7 0.1

SUB-TOTAL 221,374 199,783 219,387 215,424 206,716 0.0 4.0 -2.9COMMUNITY HEALTHHealth Policy, Mgmt & Eval 8,478 7,738 6,375 7,644 7,334 -13.2 1.1 7.9Public Health Sciences 24,014 25,018 27,141 31,353 30,025 6.3 12.0 5.6

SUB-TOTAL 32,493 32,756 33,516 38,997 37,359 1.6 13.1 13.5CLINICALAnesthesia 4,262 3,814 3,974 5,348 4,611 -3.2 19.4 10.4Family & Community Medicine 4,796 5,232 8,724 7,014 5,557 37.9 23.6 -20.2Lab. Medicine & Pathobiology 25,398 24,198 26,033 28,450 28,674 1.4 8.4 5.0Medical Imaging 7,340 9,694 9,631 6,341 6,338 15.7 -17.4 -17.1Medicine 104,876 103,601 107,835 115,248 124,146 1.4 5.5 7.3Obstetrics & Gynaecology 7,125 8,083 7,977 8,148 7,437 6.1 0.4 -3.3Occupational Therapy 1,418 1,665 2,789 1,958 2,899 42.5 18.9 9.1Ophthalmology And Vision Sci 4,537 4,917 5,527 4,643 4,445 10.4 -1.8 -10.1Otolaryngology 447 459 939 585 631 53.6 33.3 -14.9Paediatrics 20,763 27,855 41,139 46,841 55,639 40.9 30.8 16.3Physical Therapy 2,089 2,527 2,629 2,728 3,362 12.5 3.9 13.5Psychiatry 25,159 22,685 25,215 22,268 22,330 0.7 -0.3 -5.7Radiation Oncology 7,297 8,229 11,843 13,406 9,738 28.3 28.6 -7.1Speech-Language Pathology 1,500 1,650 1,457 1,496 2,278 -0.9 -4.5 27.5Surgery 25,571 38,942 34,342 35,144 33,376 20.2 -4.7 -1.3

SUB-TOTAL 242,577 263,550 290,053 299,619 311,461 9.4 6.7 3.6Other 2 11,654 14,394 11,576 12,881 10,515 2.0 -4.2 -3.5

TOTAL 508,098 510,483 554,531 566,920 566,051 4.5 5.4 1.0CFI/OIT 3 37,328 23,361 30,198 12,448 52,094 -4.1 -14.8 129.9Indirect Costs 4 1,160 7,837 1,635 12,196 8,195

GRAND TOTAL 546,586 541,682 586,365 591,564 626,340 3.7 4.6 3.4

1 Defunct Depertment of Anatomy and Cell Biology in 2001/022 Includes global research budget of the Institute for Clinical Evaluative Sciences, Structural Genomics Consortium, SARS Laboratory, UofT Equipment maintenance grants, clinical trial grants at the Sunnybrook Hospital/University of Toronto Clinic, ORDCF grants, Ontario Genomics Institute grants, undergraduate summer studentship awards, graduate studentship awards for independent study and Health Communication Research Laboratory in the Faculty of Medicine.3 CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Health Sciences Centre, University of Toronto and the University Health Network.




Synopsis of R


edicine: 2008-2009

5


DEPARTMENTBASICAnatomy and Cell Biology 1 N/A N/A N/A N/A N/A N/A N/A N/ABBDMR 47,242 22,239 23,967 41,320 29,532 -22.6 40.1 21.9Biochemistry 20,754 13,946 14,631 16,037 13,489 -13.9 7.3 -3.1Biomat & Biomed Eng 2,157 2,527 2,288 2,284 3,660 3.9 -4.8 30.0Immunology 10,745 13,095 13,478 14,038 14,519 12.4 3.5 3.8Medical Biophysics 74,422 63,924 67,695 53,799 51,037 -4.1 -7.3 -12.8Medical Genetics & Microbiology 45,709 56,797 63,593 59,446 66,991 18.1 2.7 3.1Nutritional Sciences 5,016 4,724 6,599 5,447 4,973 16.9 11.1 -13.1Pharmacology 4,056 5,885 7,617 4,540 5,118 37.3 -5.5 -13.8Physiology 11,275 12,728 15,217 14,289 15,350 16.2 6.7 0.7

SUB-TOTAL 221,376 195,865 215,085 211,200 204,669 -0.9 4.0 -2.4COMMUNITY HEALTHHealth Policy, Mgmt & Eval 8,478 7,586 6,250 7,494 7,261 -14.1 1.1 8.4Public Health Sciences 24,014 24,528 26,609 30,739 29,728 5.3 12.0 6.1

SUB-TOTAL 32,492 32,114 32,859 38,233 36,989 0.6 13.1 14.5CLINICALAnesthesia 4,262 3,739 3,896 5,243 4,566 -4.0 19.4 10.8Family & Community Medicine 4,796 5,129 8,553 6,877 5,502 36.9 23.6 -19.8Lab. Medicine & Pathobiology 25,398 23,723 25,522 27,892 28,390 0.5 8.4 5.5Medical Imaging 7,340 9,504 9,442 6,216 6,275 14.4 -17.4 -16.6Medicine 104,876 101,570 105,720 112,988 122,917 0.5 5.5 7.8Obstetrics & Gynaecology 7,125 7,924 7,821 7,988 7,363 5.0 0.4 -2.8Occupational Therapy 1,418 1,632 2,734 1,920 2,870 41.3 18.9 9.8Ophthalmology And Vision Sci 4,537 4,821 5,419 4,552 4,401 9.3 -1.8 -9.7Otolaryngology 447 450 921 573 624 52.5 33.3 -14.4Paediatrics 20,763 27,309 40,332 45,923 55,088 39.6 30.8 16.9Physical Therapy 2,089 2,477 2,577 2,674 3,329 11.3 3.9 14.1Psychiatry 25,159 22,241 24,720 21,831 22,109 -0.2 -0.3 -5.2Radiation Oncology 7,297 8,067 11,611 13,143 9,642 27.2 28.6 -6.7Speech-Language Pathology 1,500 1,617 1,428 1,467 2,256 -1.9 -4.5 28.3Surgery 25,571 38,178 33,668 34,455 33,045 18.7 -4.7 -0.9

SUB-TOTAL 242,578 258,381 284,364 293,742 308,377 8.3 6.7 4.1Other 2 11,654 14,112 11,349 12,628 10,411 0.8 -4.2 -3.1

TOTAL 508,100 500,472 543,657 555,803 560,446 3.6 5.4 1.5CFI/OIT 3 37,328 22,903 29,606 12,204 51,578 -4.7 -14.8 131.9Indirect Costs 4 11,957 8,114






Synopsis of R


edicine: 2008-2009

6

Department All Locations Campus Baycrest Bloorview CAMH HSC MSH SMH SHSC TRI UHN WCH OtherBASICBBDMR 32,140 29,378 0 0 0 1,577 1 0 0 0 1,184 0 0Biochemistry 14,968 5,938 0 0 0 8,309 70 0 0 0 614 0 37Biomat & Biomed Eng 2,787 1,660 0 379 0 0 0 0 45 330 372 0 0Immunology 14,243 2,771 0 0 0 5,813 707 0 2,443 0 2,492 17 0Medical Biophysics 58,491 2,241 375 0 0 2,466 1,698 0 16,523 0 35,187 0 0Medical Genetics & Microbiology 64,387 12,047 0 0 0 24,301 24,400 0 0 0 3,639 0 0Nutritional Sciences 5,770 4,321 56 0 0 72 145 1,176 0 0 0 0 0Pharmacology 5,856 3,983 0 0 554 64 0 685 564 0 6 0 0Physiology 15,200 8,443 0 0 0 3,872 22 481 1 0 2,371 0 10SUB-TOTAL 213,842 70,782 431 379 554 46,474 27,043 2,342 19,576 330 45,865 17 47COMMUNITY HEALTHHealth Policy, Mgmt & Eval 7,117 5,286 0 0 384 461 0 358 360 11 257 0 0Public Health Sciences 29,506 9,732 0 0 6,718 2,193 1,645 4,214 729 166 1,275 1,526 1,308SUB-TOTAL 36,623 15,018 0 0 7,102 2,654 1,645 4,572 1,089 177 1,532 1,526 1,308CLINICALAnesthesia 4,644 552 0 0 0 663 335 1,185 468 0 1,428 13 0Family & Community Medicine 7,099 957 0 0 4,226 11 119 893 244 0 310 37 301Lab. Medicine & Pathobiology 27,719 6,693 0 0 0 4,238 6,189 1,100 3,109 0 6,384 3 2Medical Imaging 7,437 382 0 0 0 842 158 36 5,856 0 164 0 0Medicine 115,743 19,210 2,204 64 189 197 12,697 23,193 15,056 1,770 39,675 1,253 234Obstetrics & Gynaecology 7,854 96 0 0 0 44 5,312 186 880 0 180 1,157 0Occupational Therapy 2,549 1,522 43 77 0 0 0 393 0 493 21 0 0Ophthalmology And Vision Sci 4,872 1,096 0 0 0 730 2 853 0 0 2,190 0 0Otolaryngology 718 41 3 0 0 444 25 26 178 0 0 0 0Paediatrics 47,873 684 0 767 0 33,655 98 44 636 36 11,545 409 0Physical Therapy 2,906 1,512 149 93 0 4 0 46 31 616 277 135 43Psychiatry 23,271 1,135 712 2 14,158 1,739 184 921 749 297 3,109 106 160Radiation Oncology 11,662 311 0 0 0 0 14 0 1,952 0 9,279 106 0Speech-Language Pathology 1,744 1,344 27 75 0 0 0 0 42 235 22 0 0Surgery 34,287 1,749 0 0 0 7,978 2,407 3,580 3,972 3,396 11,173 32 0SUB-TOTAL 300,378 37,284 3,138 1,078 18,573 50,545 27,540 32,456 33,173 6,843 85,757 3,251 740Other 11,657 5,307 0 0 179 1,236 16 107 1,594 3,012 198 0 8GRAND TOTAL 562,500 128,391 3,569 1,457 26,408 100,909 56,244 39,477 55,432 10,362 133,352 4,794 2,103




Synopsis of R


edicine: 2008-2009

7

Department All Locations Campus Baycrest Bloorview CAMH HSC MSH SMH SHSC TRI UHN WCH OtherBASICBBDMR 7,497 7,140 0 0 0 357 0 0 0 0 0 0 0Biochemistry 5,726 2,591 0 0 0 2,964 56 0 0 0 109 0 6Biomat & Biomed Eng 1,093 963 0 35 0 0 0 0 0 96 0 0 0Immunology 3,922 1,238 0 0 0 627 277 0 1,118 0 663 0 0Medical Biophysics 8,516 621 259 0 0 404 312 0 2,136 0 4,784 0 0Medical Genetics & Microbiology 16,290 5,500 0 0 0 4,156 6,364 0 0 0 269 0 0Nutritional Sciences 2,586 1,833 47 0 0 43 145 518 0 0 0 0 0Pharmacology 1,624 1,496 0 0 38 0 0 90 0 0 0 0 0Physiology 6,944 4,404 0 0 0 1,202 0 143 0 0 1,195 0 0SUB-TOTAL 54,198 25,786 306 35 38 9,753 7,154 751 3,254 96 7,020 0 6COMMUNITY HEALTHHealth Policy, Mgmt & Eval 2,242 1,699 0 0 117 85 0 36 82 0 222 0 0Public Health Sciences 9,319 4,708 0 0 449 501 1,195 826 633 123 192 281 411SUB-TOTAL 11,561 6,407 0 0 566 586 1,195 862 715 123 414 281 411CLINICALAnesthesia 1,330 348 0 0 0 380 0 291 265 0 45 0 0Family & Community Medicine 544 102 0 0 224 0 28 138 36 0 17 0 0Lab. Medicine & Pathobiology 7,678 2,020 0 0 0 1,768 1,213 175 846 0 1,657 0 0Medical Imaging 613 112 0 0 0 179 0 0 323 0 0 0 0Medicine 30,031 6,299 989 0 116 17 3,184 4,549 3,575 205 10,392 612 92Obstetrics & Gynaecology 4,787 12 0 0 0 0 2,910 0 869 0 0 996 0Occupational Therapy 429 248 0 14 0 0 0 25 0 141 0 0 0Ophthalmology And Vision Sci 870 0 0 0 0 120 0 17 0 0 733 0 0Otolaryngology 203 8 0 0 0 158 0 0 37 0 0 0 0Paediatrics 19,933 51 0 0 0 7,590 53 0 262 36 11,533 408 0Physical Therapy 714 215 0 0 0 0 0 16 20 116 246 102 0Psychiatry 9,013 645 339 0 5,290 725 55 238 151 67 1,355 83 65Radiation Oncology 937 2 0 0 0 0 0 0 49 0 886 0 0Speech-Language Pathology 477 386 27 0 0 0 0 0 0 64 0 0 0Surgery 7,113 278 0 0 0 2,008 443 499 783 149 2,934 19 0SUB-TOTAL 84,672 10,726 1,355 14 5,630 12,945 7,886 5,948 7,216 778 29,798 2,220 157Other hospitals 2,278 917 0 0 163 1,025 0 62 103 0 0 0 8GRAND TOTAL 152,709 43,836 1,661 49 6,397 24,309 16,235 7,623 11,288 997 37,232 2,501 582




Synopsis of R


edicine: 2008-2009

8

HOSPITAL FY 2004-05 FY 2005-06 FY 2006-07 FY 2007-08 FY 2008-09 2004-2007 2005-2008 2006-2009Baycrest Centre for Geriatric Care 2,824 3,177 3,583 3,454 3,671 12.6 4.6 1.3Bloorview Kid's Rehab 656 1,044 685 412 3,275 12.4 -37.1 327.9Centre for Addiction and Mental Health 24,140 22,255 28,851 25,400 24,974 10.9 8.8 -6.8Hospital for Sick Children 55,171 85,958 100,498 100,784 101,450 36.4 8.6 0.5Mount Sinai Hospital 62,284 56,945 48,503 52,957 66,916 -11.7 -2.8 17.8St. Michael's Hospital 34,379 35,077 36,826 42,109 40,290 3.5 9.7 5.0SHSC Sunnybrook site 64,826 63,356 60,741 51,023 54,366 -3.2 -10.1 -4.7 Orthopaedic & Arthritic site 78 129 25 10 . -7.7 -70.3Toronto Rehabilitation Institute 4,637 14,316 10,072 9,931 11,083 89.5 -15.5 5.1University Health Network 120,475 118,179 131,791 141,840 126,423 4.8 9.6 -1.6Women's College Hospital 12,604 7,090 4,177 7,134 3,070 -42.4 14.8 6.9Other Hospitals 2 1,660 1,242 2,115 2,223 506 22.6 37.7 -36.1


TOTAL 508,098 510,483 554,531 566,920 566,051 4.5 5.4 1.0CFI/OIT 4 37,328 23,361 30,198 12,448 52,094 -4.1 -14.8 129.9Indirect Costs 5 12,196 8,195

GRAND TOTAL 6 545,426 533,844 584,730 591,564 626,340 3.7 5.4 3.5






Synopsis of R


edicine: 2008-2009

9


HOSPITALBaycrest Centre for Geriatric Care 2,824 3,115 3,512 3,386 3,635 11.5 4.6 1.9Bloorview Kid's Rehab 656 1,023 671 404 3,243 10.8 -37.1 331.9Centre for Addiction and Mental Health 24,140 21,819 28,285 24,902 24,727 10.0 8.8 -6.3Hospital for Sick Children 55,171 84,273 98,527 98,808 100,445 34.8 8.6 1.0Mount Sinai Hospital 62,284 55,829 47,552 51,918 66,253 -12.6 -2.8 18.4St. Michael's Hospital 34,379 34,389 36,104 41,284 39,892 2.5 9.7 5.5SHSC Sunnybrook site 64,826 62,114 59,550 50,022 53,827 -4.2 -10.1 -4.2 Orthopaedic & Arthritic site 76 126 25 10 -7.7 -70.1Toronto Rehabilitation Institute 4,637 14,035 9,874 9,736 10,973 86.5 -15.5 5.7University Health Network 120,475 115,862 129,207 139,059 125,171 3.8 9.6 -1.2Women's College Hospital 12,604 6,951 4,095 6,994 3,039 -43.0 14.8 7.1Other Hospitals 2 1,660 1,217 2,073 2,179 501 21.8 37.7 -36.0


TOTAL 508,098 500,473 543,658 555,804 560,446 3.6 5.4 1.5CFI/OIT 4 37,328 22,903 29,606 12,204 51,578 -4.7 -14.8 131.9Indirect Costs 5 1,160 7,684 1,603 11,957 8,114

GRAND TOTAL 546,586 531,060 574,868 579,965 620,138 2.7 4.6 3.9

1 Percentage represents the annual changes in funding averaged over each three year period.2 Non-affiliated hospitals and Institute of Work and Health3 Research at locations other than U of T campus or other affiliated/non-affiliated hospitals.4 The CFI and OIT funding represents physical infrastructure grants to the Hospital for Sick Children, Mt. Sinai Hospital, St. Michael's Hospital, the Sunnybrook Health Sciences Centre, University of Toronto and the University Health Network.






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SOURCE FY 2001-02 % FY 2002-03 % FY 2003-04 % FY 2004-05 % FY 2005-06 % FY 2006-07 % FY 2007-08 % FY 2008-09 %FEDERAL GOV.Federal Canada 109,557 35.8 131,170 37.4 144,361 35.5 186,328 36.7 192,543 37.7 219,249 39.5 210,337 37.1 204,427 36.1Federal U.S. 20,047 6.5 14,727 4.2 19,166 4.7 17,013 3.3 17,448 3.4 22,692 4.1 17,586 3.1 18,778 3.3Federal Other . . 8 0.0 . . . . 7 0.0 0 0.0 55 0.0 0 0.0Sub-Total 129,603 42.3 145,906 41.6 163,528 40.2 203,341 40.0 209,997 41.1 241,941 43.6 227,977 40.2 223,204 39.4PROVINCIAL GOV.Provincial Canada 45,277 14.8 41,085 11.7 61,892 15.2 93,380 18.4 77,447 15.2 60,836 11.0 76,336 13.5 67,293 11.9Sub-Total 45,277 14.8 41,085 11.7 61,892 15.2 93,380 18.4 77,447 15.2 60,836 11.0 76,336 13.5 67,293 11.9LOCAL SOURCESLocal 10,617 3.5 15,339 4.4 18,640 4.6 26,695 5.3 32,968 6.5 31,929 5.8 40,165 7.1 46,657 8.2Internal Univ/Hosp 10,738 3.5 12,722 3.6 12,550 3.1 13,836 2.7 12,927 2.5 18,936 3.4 14,428 2.5 23,989 4.2Sub-Total 21,355 7.0 28,061 8.0 31,190 7.7 40,531 8.0 45,894 9.0 50,865 9.2 54,593 9.6 70,646 12.4INDUSTRYCanadian Industry 20,815 6.8 22,077 6.3 19,731 4.8 25,219 5.0 22,070 4.3 25,284 4.6 25,762 4.5 21,707 3.8U.S. Industry 7,612 2.5 13,111 3.7 14,515 3.6 10,297 2.0 12,273 2.4 12,965 2.3 15,132 2.7 18,852 3.3Other Foreign Ind. 1,478 0.5 1,138 0.3 11,138 2.7 2,434 0.5 4,130 0.8 4,402 0.8 7,446 1.3 6,916 1.2Sub-Total 29,905 9.8 36,327 10.3 45,384 11.1 37,950 7.5 38,473 7.5 42,651 7.7 48,341 8.5 47,476 8.3NOT-FOR-PROFITCanadian Charity 46,403 15.2 60,666 17.3 65,461 16.1 73,970 14.6 74,207 14.5 84,244 15.2 81,378 14.4 83,386 14.7Provincial Charity 12,665 4.1 15,875 4.5 14,746 3.6 16,792 3.3 17,602 3.4 25,476 4.6 19,674 3.5 18,520 3.3U.S. Charity 7,490 2.4 7,066 2.0 8,449 2.1 8,949 1.8 10,609 2.1 13,602 2.5 14,240 2.5 15,170 2.7Other Foreign Charity 1,925 0.6 1,550 0.4 1,675 0.4 432 0.1 384 0.1 307 0.1 1,416 0.2 3,575 0.6Sub-Total 68,482 22.3 85,157 24.2 90,330 22.2 100,142 19.8 102,801 20.1 123,630 22.4 116,707 20.6 120,651 21.3OTHEROther Canadian Inst. 2,333 0.8 1,935 0.6 1,899 0.5 5,057 1.0 6,627 1.3 6,506 1.2 8,025 1.4 7,696 1.4U.S. Institutions 1,840 0.6 2,337 0.7 1,789 0.4 8,018 1.6 6,717 1.3 6,027 1.1 6,787 1.2 7,058 1.2Other Foreign Inst. 231 0.1 327 0.1 248 0.1 205 0.0 384 0.1 135 0.0 214 0.0 787 0.1Sub-Total 4,404 1.5 4,600 1.4 3,936 1.0 13,281 2.6 13,728 2.7 12,668 2.3 15,026 2.6 15,541 2.7MISCELLANEOUSVarious Sponsors 7,181 2.3 9,769 2.8 10,764 2.6 19,473 3.8 22,142 4.3 20,462 3.7 27,941 4.9 20,514 3.6Sub-Total 7,181 2.3 9,769 2.8 10,764 2.6 19,473 3.8 22,142 4.3 20,462 3.7 27,941 4.9 20,514 3.6TOTAL 306,208 100 350,905 100 407,024 100 508,098 100 510,483 100 553,053 100 566,920 100 565,325 100CFI/OIT1 39,839 35,186 60,464 37,328 23,361 30,198 12,448 52,094Indirect Costs 2 776 1,160 7,837 1,635 12,196 8,195GRAND TOTAL 3 346,047 100 386,091 100 468,264 100 546,586 100 541,682 100 584,887 100 591,564 100 625,614 100Fiscal Year values represent THOUSANDS of dollars.1 The CFI and OIT funding represents infrastructure grants from Federal and Provincial sources.

3 2003-04 value excludes $11,804,786; 2004-05 excludes $12,946,032; 2005-06 excludes $15,081,736; 2006-07 excludes $17,922,835; 2007-08 excludes $18,440,070; 2008-09 excludes $17,974,589




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0%

20%

40%

60%

80%

100%19

87

1988

1989

1990

1991

1992

1993

1994

1995

1996

1997

1998

1999

2000

2001

2002

2003

2004

2005

2006

2007

2008

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300

400

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Tota

l Fun

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(Mill

ions

)


Other Sources

CIHR Contribution


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GRAND TOTAL 4 $626,339,646 7765








13

DEPARTMENTPrimary Appt On Campus Off Campus Cross Appt Tenure Appt Tenure Stream Career Awards Pri Appt with

Res Funds


Pri Appt


BASICBBDMR 26 25 1 6 15 9 8 25 50 41Biochemistry 34 19 15 21 18 1 14 29 101 21Biomat & Biomed Eng 14 12 2 77 27 7 1 13 7 14Immunology 30 5 25 33 5 3 5 19 78 36Medical Biophysics 88 0 88 59 2 0 17 63 192 150Molecular Genetics 65 27 38 36 22 5 27 58 241 181Nutritional Sciences 25 15 10 17 8 2 3 18 59 4Pharmacology 33 17 16 32 3 4 4 16 41 3Physiology 37 21 16 62 16 2 15 33 234 111SUB-TOTAL 352 141 211 343 116 33 94 274 1,003 561COMMUNITY HEALTHHealth Policy, Mgmt & Eval 97 0 97 163 13 2 4 25 103 7Public Health Sciences 192 39 153 116 18 4 14 77 128 5SUB-TOTAL 289 39 250 279 31 6 18 102 231 12CLINICALAnesthesia 290 1 289 5 2 0 3 29 30 98Family & Community Medicine 931 0 931 66 0 0 2 20 19 0Lab. Medicine & Pathobiology 232 20 212 69 12 2 9 79 164 89Medical Imaging 160 2 158 25 2 0 1 18 16 9Medicine 935 23 912 104 5 0 75 312 367 220Obstetrics & Gynaecology 158 1 157 43 2 0 2 26 21 38Occupational Therapy 29 26 3 2 8 3 2 13 182 1Ophthalmology And Vision Sci 132 4 128 11 1 0 2 17 24 32Otolaryngology 76 0 76 21 1 0 0 7 7 23Paediatrics 406 0 406 30 1 0 14 124 128 79Physical Therapy 29 24 5 5 6 5 5 14 209 0Psychiatry 748 0 748 49 3 0 14 105 101 46Radiation Oncology 124 0 124 6 0 0 3 22 108 30Speech-Language Pathology 11 11 0 6 8 1 3 11 128 1Surgery 352 7 345 60 3 0 19 129 149 184SUB-TOTAL 4,613 119 4,494 502 54 11 154 926 1,653 850TOTAL 5,254 299 4,955 1,124 201 50 266 1,302 2,887 1,423Based on data received from each individual Department



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Prim ApptPost-Doctoral

FellowsBaycrest Centre for Geriatric Care 20 1 5 6Bloorview Kid's Rehab 10 4 5 6Centre for Addiction and Mental Health 75 13 38 27Hospital for Sick Children 266 38 172 340Mount Sinai Hospital 121 17 107 105St. Michael's Hospital 178 31 104 16SHSC 77 Sunnybrook site 157 26 22 no breakdown Orthopaedic & Arthritic site 1 0 0 no breakdownToronto Rehabilitation Institute 24 4 10 22University Health Network 249 52 291 480Women's College Hospital 15 6 5 2TOTAL 1101 186 754 1081Hospital Post-doc numbers based on data provided by each individual hospital




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DEPARTMENT Nasm1

BASICBanting and Best Department of Medical Research 1741Biochemistry 1800Institute of Biomaterials & Biomedical Engineering 2 1082Immunology 754Molecular Genetics 2246Nutritional Sciences 1087Pharmacology 1451Physiology 2065


Sub-Total 2,320CLINICALOccupational Therapy 693Physical Therapy 1046Speech-Language Pathology 574Surgery (includes Anatomy Div.) 396

Sub-Total 2,709OTHERBiomedical Communications 53Centre for Research in Neurodegeneratice Disease 1534Centre for Cellular & Biomolecular Research (Terrence Donnelly) 5992Comparative Medicine 4228Common Research Space 1527Electron Microscopy Unit 241Heart & Stroke / Richard Lewar Centre for Excellence… 321Rehabilitation Sciences Sector 135Structural Genomics Consortium 320


Based on a data extracted on: Dec 20091 Nasm - Net assignable square meters2 Includes ONLY IBBME research space at the MSB

Table 9




16




External - Other $1,900,900.96 $4,925,372.77 $6,826,273.73

External - Unspecified by Hospital $1,389,873.33 $3,706,437.66 $5,096,310.99

Internal - U of T $11,089,311.07 $4,625,256.36 $15,714,567.43

Grand Total $25,785,141.15 $22,279,085.10 $48,064,226.25


Type of Funding




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Graduate Unit AWARD STIPEND Grand TotalBiochemistry $1,224,009.31 $1,217,173.96 $2,441,183.27Graduate Department of Rehabilitation Science $912,665.52 $308,212.27 $1,220,877.79Health Policy, Management & Evaluation $1,880,956.57 $1,446,846.43 $3,327,803.00Immunology $877,018.49 $775,096.05 $1,652,114.54Institute of Biomaterials & Biomedical Engin. $1,843,636.83 $1,037,960.60 $2,881,597.43Institute of Medical Science $5,558,568.26 $5,632,406.08 $11,190,974.34Laboratory Medicine & Pathobiology $1,667,003.53 $1,752,483.77 $3,419,487.30Medical Biophysics $2,636,241.04 $2,042,669.83 $4,678,910.87Molecular Genetics $2,368,171.90 $3,536,661.84 $5,904,833.74Nutritional Sciences $876,854.16 $541,973.75 $1,418,827.91Occupational Health Sceince & Occupational Therapy $221,639.66 $5,604.00 $227,243.66Pharmacology $587,135.81 $649,873.73 $1,237,009.54Physical Therapy $344,098.90 $68.20 $344,167.10Physiology $2,014,412.98 $2,707,710.65 $4,722,123.63Public Health Sciences (Dalla Lana School of) $2,229,429.75 $610,096.46 $2,839,526.21Speech-Language Pathology $543,298.44 $38,147.48 $581,445.92


Type of Funding




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Awards Stipend1

Baycrest/Rotman Institute $62,500.33 $98,900.00 $161,400.33Bloorview Kid's Rehab $15,000.00 $19,000.00 $34,000.00Centre for Addiction and Mental Health $193,558.33 $477,055.00 $670,613.33Hospital For Sick Children $1,609,146.81 $2,593,523.78 $4,202,670.59Mount Sinai Hospital $633,067.00 $1,311,694.22 $1,944,761.22St. Michael's Hospital $192,449.16 $482,480.05 $674,929.21Sunnybrook Health Sciences Centre $612,631.83 $1,493,969.78 $2,106,601.61Toronto Rehabilitation Institute $10,000.00 $70,095.06 $80,095.06University Health Network $1,647,719.67 $2,971,985.97 $4,619,705.64Women's College Hospital $20,000.00 $0.00 $20,000.00Other $709,707.66 $791,786.63 $1,501,494.29

Off Campus Total $5,705,780.79 $10,310,490.49 $16,016,271.28



OSOTF/Hospital for Sick Children $728,993.80OSOTF/Mount Sinai Hospital $197,233.33OSOTF/Princess Margaret Hospital $103,250.00OSOTF/Toronto Rehabilitation Institute $199,500.00








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20





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Total Number of Awards: 93 Primary Appointments 290 On Campus 1 Off Campus 289 Cross Appointments 5 CIHR $1,073,164 Tenured 2 NSERC $65,064 Tenure-stream 0 NCIC $0 Career Awards 3 HLTH CAN $0 With Research Funds MOH $21,942 Primary Appointments 29 HSFO/C $0 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $1,043,586 Supervised by Primary Appt 30 Other Sources $2,407,442 Fellows: Post-Doc. and Clin. 98

Overall Research Objective : To develop the environment and recruit personnel for the generation of research of the highest quality necessary for the advancement of knowledge in the areas of interest to Anesthesia and Perioperative Care. Current Major Areas of Research : Faculty in the Department of Anesthesia have developed research interests and programs in a number of fields related to anesthesia, pain management and peri-operative medicine. These include the following major areas, each represented by an identified contact person. Please also visit the research section of our Departmental web site for more information (www.anesthesia.utoronto.ca). Acute Pain C. McCartney 480-6100 [email protected] Ambulatory Anesthesia F. Chung 603-5118 [email protected] Anesthesia mechanisms B. Orser 978-0574 [email protected] Anemia/Hypoxia Lab Research G. Hare 864-5259 [email protected] Blood Conservation K. Karkouti 340-5164 [email protected] Cardiovascular D. Mazer 864-5825 [email protected] Critical Care B. Kavanagh 978-4306 [email protected] Education P. Houston 864-5071 [email protected] Neuroscience B. Orser 978-0574 [email protected] A. Baker 864-5510 [email protected] Obstetrical Management S. Halpern 323-6008 [email protected] Outcomes Research S. Beattie 340-5164 [email protected] Pediatrics M. Crawford 813-7445 [email protected] Regional Anesthesia V. Chan 603-5118 [email protected] Simulation P. Morgan 323-6269 [email protected] - Text last updated October 2009


22




Overall Research Objective : To use proteomics, functional genomics and bioinformatics to achieve a comprehensive view of gene function, cell regulatory pathways and gene/protein networks. To understand the molecular basis of biological disorders. Current Major Areas of Research : • Cell cycle • Control of gene expression • Developmental biology • Functional genomics • Mechanism of action of hormones • Membrane structure and function • Muscle biology • Proteomics • Structural biology - Text last updated October 2009


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Total Number of Awards: 219 Primary Appointments 34 On Campus 19 Off Campus 15 Cross Appointments 21 CIHR $5,150,123 Tenured 18 NSERC $630,615 Tenure-stream 1 NCIC $944,551 Career Awards 14 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 29 HSFO/C $302,067 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $248,286 Supervised by Primary Appt 101 Other Sources $6,347,845 Fellows: Post-Doc. and Clin. 21

Overall Research Objective : To advance and disseminate our understanding of the molecular fundamentals of life through first rate research and academic programs. Current Major Areas of Research : • Biomolecular structure and function • Gene expression and development • Membranes and transport • Molecular cell biology • Molecular medicine • Protein folding • Proteomics and Bioinformatics • Signal transduction and regulation - Text last updated November 2009


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Total Number of Awards: 63 Primary Appointments 931 On Campus 0 Off Campus 931 Cross Appointments 66 CIHR $546,963 Tenured 0 NSERC $0 Tenure-stream 0 NCIC $42,715 Career Awards 2 HLTH CAN $209,972 With Research Funds MOH $1,851,057 Primary Appointments 20 HSFO/C $0 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $48,804 Supervised by Primary Appt 19 Other Sources $2,857,741 Fellows: Post-Doc. and Clin. 0

Overall Research Objective : To undertake a program of applied clinical and health services research with the goals of improving population access to, and the quality of, primary care in Canada. The DFCM’s research themes of “enhancing quality and effectiveness” are overarching themes that encompass the previous themes of “effectiveness, equity and education”. Current Major Areas of Research : • Evaluating methods of dissemination and uptake of evidence into practice • Improving clinical practice in the areas of prevention, prenatal care, addictions, inner city

health, primary care genetics, care of the elderly, cancer care, prescribing, care of people with chronic disabling conditions, and knowledge translation

• Improving population access to primary care - Text last updated October 2009


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Total Number of Awards: 149 Primary Appointments 97 On Campus 0 Off Campus 97 Cross Appointments 163 CIHR $1,905,127 Tenured 13 NSERC $0 Tenure-stream 2 NCIC $0 Career Awards 4 HLTH CAN $57,311 With Research Funds MOH $2,341,091 Primary Appointments 25 HSFO/C $68,500 Cross Appointments unk SSHRC $30,487 Studentship Awards: Industry $0 Supervised by Primary Appt 103 Other Sources $2,931,269 Fellows: Post-Doc. and Clin. 7

Overall Research Objective : To contribute to knowledge, thereby advancing the discipline, improving teaching and improving the theory and practice of health services management and administration and clinical epidemiology. To educate researchers through the M.Sc./Ph.D. program and to foster an appreciation of the methods and application of health services research among graduate students. Current Major Areas of Research : • Clinical evaluative sciences • Financing of health services • Health measurement • Health care improvement • Health performance assessment • Health policy and economics • Organizational research • Outcomes research • Program planning and evaluation - Text last updated Jan 2010


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Total Number of Awards: 150 Primary Appointments 30 On Campus 5 Off Campus 25 Cross Appointments 33 CIHR $4,086,749 Tenured 5 NSERC $68,500 Tenure-stream 3 NCIC $505,003 Career Awards 5 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 19 HSFO/C $297,332 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $485,030 Supervised by Primary Appt 78 Other Sources $9,221,093 Fellows: Post-Doc. and Clin. 36

Overall Research Objective : To achieve a fundamental understanding of molecular and cellular aspects of the immune system towards elucidating mechanisms underlying host-pathogen interactions and disease resistance. Current Major Areas of Research : • Antigen presentation • B-cell/T-cell ontogeny • Biochemistry of antigen receptor and cytokine receptor signalling • Cell adhesion molecules • Gene expression • Gene rearrangement in antigen receptor structures • Generation of diversity • Hybridoma technology • Human Immunology • Immune disorder & autoimmunity • Immunity to infectious disease • Immunodeficiencies • Lymphokine synthesis and action • Protein structure/function relationships • Repertoire development • Tolerance: self/non-self discrimination • Transgenic and knockout technology • Tumour immunology • Vaccine development - Text last updated October 2009


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Fac of Med primary appointments $3,697,085 Primary Appointments 14 On Campus 12 Total Number of Awards: 57 Off Campus 2 Cross Appointments 77 CIHR $1,091,801 Tenured 27 NSERC $118,415 Tenure-stream 7 NCIC $0 Career Awards 1 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 13 HSFO/C $70,154 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $165,465 Supervised by Primary Appt 7 Other Sources $2,251,250 Fellows: Post-Doc. and Clin. 14


cardiovascular and soft tissue biomaterials; stem cell bioengineering and functional genomics; drug delivery systems, tissue engineering scaffolds, host response and functional integration. Hemodynamics, cellular and tissue biomechanics, cellular engineering


• Molecular Imaging and Systems Biology: Scanning probe microscopy, quantum dots, genetic circuits, microarray technology development, microfluidics and MEMS, cellular systems modeling, single molecule biophysics, functional cellular imaging





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Overall Research Objective : To carry out innovative and high impact basic, translational and applied research in pathology and laboratory medicine particularly as it relates to cellular, biochemical and molecular mechanisms of human disease. Current Major Areas of Research : • Biotechnology • Bone, joint and connective tissue diseases • Cancer pathobiology and diagnostics • Developmental biology and pathobiology • Endocrine diseases • Immunopathology and transplantation • Infection and immunity • Inflammation, repair, remodeling • Molecular epidemiology • Molecular and clinical genetics • Neuropathology • Personalized and predictive medicine, targeted therapies (including biobanking, biomarkers,

informatics) • Regenerative medicine, tissue engineering • Vascular and cardiovascular pathobiology - Text last updated October 2009


29




Overall Research Objective : To conduct basic and applied research related to human health with an emphasis on cancer. Current Major Areas of Research : • Angiogenesis • Animal models of human disease • Bioinformatics • Cancer biology • Cardiovascular Research • Developmental Biology • Digital radiography • Drug resistance mechanisms • Experimental therapeutics • Genomics/proteomics applied to medical research • High throughput structural genomics • Image guided therapeutics • Immunological tolerance and autoreactivity • Intracellular signalling pathways • Magnetic resonance imaging • Macromolecular electron microscopy • Macromolecular structure and function • Molecular genetics of cancer • Molecular-Immunological mechanisms • Optical Imaging and therapy • Stem Cells • Ultras

- Text last updated October 2009


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DEPARTMENT: Molecular Genetics (formerly Medical Genetics & Microbiology)



Overall Research Objective : The mission of the Department of Molecular Genetics is to conduct world-class research and to train outstanding students in several cutting-edge research areas. Molecular biological, molecular genetic, cellular and systems biological approaches are applied tto studies in six research areas: 1) functional genomics and proteomics; 2) molecular biology and macromolecular structure; 3) molecular medicine and human genetics; 4) model organism genetics and genetic control of development; 5) cell biology and signal transduction; 6) systems biology, computational biology and bioinformatics; and 7) molecular microbiology, virology and infectious disease research. Our aims are to: 1. Establish and/or maintain internationally competitive research programs in the areas listed above; 2. train future generations of independent scientists. Current Major Areas of Research : Signal transduction and cell regulation - Cell cycle and growth control - Transcriptional and post-transcriptional regulation of gene expression - Epigenetics and chromatin regulation - Chromosome dynamics and biology - Functional genomics - Nucleic acid metabolism and function - Structural biology using X-ray crystallography and NMR spectroscopy - Proteomics - Systems biological and bioinformatic analysis of gene regulatory networks, protein interaction networks, cell cycle and development - Analyses of complex genetic disease and single gene disorders - Disease gene mapping and identification - Genome annotation - Cell biology and developmental biology of disease states - Human chromosome structure, function and dynamics - Molecular diagnostics and gene therapy - Yeast, worm, fly, zebrafish, frog and mouse models of development - Stem cell research, haematopoiesis and cancer stem cells - Neurogenesis and neurobiology - Host-pathogen (viral, bacterial, fungal) interaction - Viral and plasmid segregation - Viral RNA transport and processing Departmental Website: http://www.moleculargenetics.utoronto.ca - Text last updated June 2008


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Total Number of Awards: 64 Primary Appointments 160 On Campus 2 Off Campus 158 Cross Appointments 25 CIHR $563,074 Tenured 2 NSERC $63,635 Tenure-stream 0 NCIC $71,172 Career Awards 1 HLTH CAN $0 With Research Funds MOH $1,026,586 Primary Appointments 18 HSFO/C $21,000 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $259,236 Supervised by Primary Appt 16 Other Sources $4,333,503 Fellows: Post-Doc. and Clin. 9

Overall Research Objective : Characterization of the structure and function of normal and diseased tissue using all modern imaging methods. Physiologically specific imaging at the metabolic, cellular, vascular and tissue level, using MRS, PET, MRI and MEG. Current Major Areas of Research : • Clinical trials of new contrast agents and drugs • Design of new imaging techniques and imaging systems • Integration of imaging data • Magnetic resonance imaging and spectroscopy • MEG • Minimally invasive diagnosis and therapy • Molecular imaging • CIP Program • Percutaneous and transvascular treatment methods • PET/CT • Picture archival and communications systems (PACS) • Real-time imaging • Tissue characterization by imaging • Volumetric dynamic multi-slice CT • Educational metrics in hands-on training of image guided therapy. - Text last updated October 2009


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Total Number of Awards: 1571 Primary Appointments 935 On Campus 23 Off Campus 912 Cross Appointments 104 CIHR $29,732,270 Tenured 5 NSERC $215,785 Tenure-stream 0 NCIC $1,858,838 Career Awards 75 HLTH CAN $1,093,132 With Research Funds MOH $2,078,540 Primary Appointments 312 HSFO/C $7,841,259 Cross Appointments unk SSHRC $57,034 Studentship Awards: Industry $20,104,828 Supervised by Primary Appt 367 Other Sources $61,164,806 Fellows: Post-Doc. and Clin. 220

Overall Research Objective : To achieve excellence and international recognition. Current Major Areas of Research : • Cardiology: vascular biology/coronary artery disease, congestive heart failure, cardiac

arrhythmias, inflammatory mechanisms in atherosclerosis, systemic inflammatory response syndrome, integrated cardiovacular physiology

• Clinical Immunology: allegic disorders, congenital immunodeficiency disorders, asthma • Clinical Pharmacology: drug safety • Dermatology: immunodermatology, skin cancer • Emergency Medicine: prehospital care/trauma, inner city health • Endocrinology/Metab: diabetes, dyslipidemias and atherosclerosis, bone & mineral metabolism • Gastroenterology: cellular and molecular mechanisms of inflammation and organ injury,


• General Internal Medicine: clin epidemiology & health care research,clinical bioethics,medical educational research



institutional infection control, global health (malaria, TB), sepsis, cellular and molecular mechanisms of organ failure/dysfunction

• Medical Oncology: genetic predisposition to cancer, molecular markers of cancer, molecular mechanisms of drug resistance, angiogenesis physiology: bench to bedside

• Nephrology: cellular and molecular mechanisms of inflammation and organ injury, membrane biology and cell signalling, integrative renal physiology: bench to bedside

• Neurology: neurodegenerative disease, neuro-ophthalmology, multiple sclerosis, epilepsy • Non-Divisional: molecular medicine, women’s health • Occupational Medicine: occupational and environmental injury • Physiatry: outcome measurement and functional assessment • Respirology: acute lung injury/respiratory failure, asthma/obstructive airway disease, sleep-


osteoporosis, musculoskeletal disease in the community & work force. - Text last updated Dec 2009


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Total Number of Awards: 120 Primary Appointments 25 On Campus 15 Off Campus 10 Cross Appointments 17 CIHR $1,575,490 Tenured 8 NSERC $474,114 Tenure-stream 2 NCIC $0 Career Awards 3 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 18 HSFO/C $0 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $234,941 Supervised by Primary Appt 59 Other Sources $2,737,843 Fellows: Post-Doc. and Clin. 4

Overall Research Objective : To advance the health of the population through basic, clinical and community aspects of human nutrition. Current Major Areas of Research : Bone Health W. E.Ward 946-7366 [email protected] Carbohydrate/Fibre T. Wolever 978-5556 [email protected] Metabolism Community and V. Tarasuk 978-0618 [email protected] Public Health Nutrition Diabetes and D. Jenkins 978-4752 [email protected] Cardiovascular Disease Diet and Cancer M.C. Archer 978-8195 [email protected] Food Intake Regulation G.H. Anderson 978-1832 [email protected] and Obesity Functional Foods and V. Vuksan 864-5525 [email protected] Nutriceuticals Lipid Metabolism R. Bazinet 946-8276 [email protected] Nutrigenetics and A. El-Sohemy 946-5776 [email protected] Nutrigenomics Nutrition and Brain Function/ C. Greenwood 978-4261 [email protected] Behaviour Nutrition in Diseased P. Darling 864-5535 [email protected] Populations Nutritional Toxicology M.C. Archer 978-8195 [email protected] Paediatric Nutrition D. O’Connor 813-7844 deborah_l.o’[email protected] Protein and Amino Acid P. Pencharz 813-6169 [email protected] Metabolism Vitamin and Mineral W. E. Ward 946-7366 [email protected] Metabolism Departmental Web-site is http://www.utoronto.ca/nutrisci/depthome.htm - Text last updated October 2009


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Total Number of Awards: 106 Primary Appointments 158 On Campus 1 Off Campus 157 Cross Appointments 43 CIHR $3,881,041 Tenured 2 NSERC $36,500 Tenure-stream 0 NCIC $0 Career Awards 2 HLTH CAN $2,543 With Research Funds MOH $92,423 Primary Appointments 26 HSFO/C $31,645 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $58,501 Supervised by Primary Appt 21 Other Sources $3,334,009 Fellows: Post-Doc. and Clin. 38

Overall Research Objective : To achieve International recognition as a centre of excellence in women’s health research Current Major Areas of Research : • Clinical and basic perinatology • Control of parturition • Gynecologic cancers • Health services and health outcomes • Medical education • Minimally-invasive surgery • Molecular control of early fetal and placental growth • Multicentre perinatal randomized controlled trials • Paediatric and adolescent gynecology • Reproductive biology • Urogynecology and pelvic floor disorders • Developmental origins of adult health and disease - Text last updated October 2009


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Overall Research Objective : The Department of Occupational Science and Occupational Therapy will focus its science on advancing the knowledge of occupation and its enablement. The systematic study of daily occupations and their meanings in the lives of people of all ages and abilities will serve to improve the life and well being of individuals, families, groups, communities and societies, breaking through barriers encountered in all aspects of daily living.

Current Major Areas of Research : • Theory, practice models and measurement of enabling occupational performance across

lifespan, cultures and diagnoses • Recovery and community re-integration in severe mental illnesses • Prevention and long term outcomes in traumatic brain injuries • Upper extremity function • Cognitive rehabilitation in acquired brain injuries • Rehabilitation technologies: artificial intelligence, virtual reality, orthoses, aids and appliances • Quality of life • Caregiver support • Global health, disability and rehabilitation • Childhood occupations • Return to work and work-life balance • Aging and social participation • Educational scholarship: simulation technologies, interprofessional education, professional

education, research utilization - Text last updated October 2009


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Total Number of Awards: 80 Primary Appointments 132 On Campus 4 Off Campus 128 Cross Appointments 11 CIHR $995,561 Tenured 1 NSERC $0 Tenure-stream 0 NCIC $374,908 Career Awards 2 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 17 HSFO/C $0 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $440,631 Supervised by Primary Appt 24 Other Sources $2,634,022 Fellows: Post-Doc. and Clin. 32

Overall Research Objective : To conduct fundamental research on the eye and visual processing and to apply this knowledge to the alleviation of ocular disease and the prevention of blindness. Current Major Areas of Research : • Cancer of the eye and orbit • Corneal external diseases • Corneal transplantation • Diabetic retinopathy • Glaucoma: diagnosis and therapeutics • Hereditary retinal degenerations: molecular genetics • Lacrimal investigation • Neuro Ophthalmology • Ocular infectious diseases • Ophthalmic Epidemiology • Paediatric ophthalmology • Retinal Imaging • Retinitis pigmentosa • Strabismus and Eye Movement • Ultrasound biomicroscopy • Visual electrophysiology and psychophysics - Text last updated October 2009


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DEPARTMENT: Otolaryngology – Head and Neck Surgery


Total Number of Awards: 16 Primary Appointments 76 On Campus 0 Off Campus 76 Cross Appointments 21 CIHR $203,330 Tenured 1 NSERC $0 Tenure-stream 0 NCIC $0 Career Awards HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 7 HSFO/C $0 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $32,500 Supervised by Primary Appt 7 Other Sources $394,828 Fellows: Post-Doc. and Clin. 23

Overall Research Objective : To contribute to basic science knowledge as it relates to the inner ear, upper respiratory tract, and disorders of the neck and skull base.To explore and implement evidence based practices in otolaryngology – head and neck surgery. Current Major Areas of Research : • Auditory neuroscience • Cochlear implants: basic science and clinical studies • Head and neck oncology: treatment and epidemiology • New techniques in skull-base surgery • Outcome measures in Head and neck surgery • Hearing loss and associated communication disorders • Laryngeal function and dysfunction • Voice studies • Genetics and etiology of congential hearing loss • Psychoacoustics • Upper respiratory tract biology • Vestibular and oculomotor studies: clinical and basic - Text last updated October 2009


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Total Number of Awards: 538 Primary Appointments 406 On Campus 0 Off Campus 406 Cross Appointments 30 CIHR $20,612,253 Tenured 1 NSERC $126,339 Tenure-stream 0 NCIC $770,672 Career Awards 14 HLTH CAN $76,442 With Research Funds MOH $552,436 Primary Appointments 124 HSFO/C $801,312 Cross Appointments unk SSHRC $47,220 Studentship Awards: Industry $3,082,925 Supervised by Primary Appt 128 Other Sources $29,569,617 Fellows: Post-Doc. and Clin. 79

Overall Research Objective : To study mechanisms of disease and health maintenance in infants and children utilizing molecular, biochemical and epidemiological methods. Current Major Areas of Research : • Brain and behavioural research • Cancer and blood research • Cardiovascular research • Developmental biology • Genetics and genomic biology • Metabolic research, including Diabetes • Clinical Pharmacology and Toxicology • Health Care Outcomes - Text last updated October 2009


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DEPARTMENT: Pharmacology and Toxicology


Total Number of Awards: 93 Primary Appointments 33 On Campus 17 Off Campus 16 Cross Appointments 32 CIHR $1,752,345 Tenured 3 NSERC $83,568 Tenure-stream 4 NCIC $0 Career Awards 41


Overall Research Objective : To investigate and understand the interaction of chemical compounds with living systems. To strengthen the department through the development of research related to the mechanisms of drug action and toxicity. Current Major Areas of Research : • Behavioural pharmacology and drug addiction • Biochemical and molecular pharmacology • Clinical pharmacology • Drug metabolism and distribution • Drug safety and toxicology • Neuropharmacology and psychopharmacology • Pharmacogenetics • Receptor pharmacology • Second messengers and signal transduction - Text last updated October 2009



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continuum care - Text last updated October 2009


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Overall Research Objective: Key Priorities:

• To expand and enrich four key areas of research represented by our Research Platforms: o Brain Research and Integrative Neurophysiology o Cardiovascular o Reproduction & Development o Endocrinology & Diabetes

• To foster a research culture in which all aspects of discovery are explored. • To integrate our research activities with the clinical and research activities of our sister

hospital-based research institutes. • To develop and foster partnerships with University of Toronto-affiliated research institutes

and centres, as well as national and international centres of excellence. • To recruit and retain the best researchers in our key research areas. • To provide an outstanding environment for post-doctoral and graduate trainees. • To provide specialized undergraduate teaching to Arts & Science students with the

objective of attracting the best students into our graduate program. • To create and maintain a supportive environment for clinician scientists.

Key Challenges: • To develop and maintain world-class research infrastructure for faculty. • To develop advancement strategies that enhance research capacity and infrastructure in

the Department. • To expand competitive funding for research and training initiatives between the

Department of Physiology and our international, national and local research partner Current Major Areas of Research:

o Brain Research and Integrative Neurophysiology o Cardiovascular o Reproduction & Development o Endocrinology & Diabetes

www.physiology.utoronto.ca - Text last updated October 2009


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Total Number of Awards: 365 Primary Appointments 748 On Campus 0 Off Campus 748 Cross Appointments 49 CIHR $8,197,804 Tenured 3 NSERC $116,087 Tenure-stream 0 NCIC $57,500 Career Awards 14 HLTH CAN $0 With Research Funds MOH $164,815 Primary Appointments 105 HSFO/C $399,367 Cross Appointments unk SSHRC $812,863 Studentship Awards: Industry $3,762,595 Supervised by Primary Appt 101 Other Sources $8,818,844 Fellows: Post-Doc. and Clin. 46

Overall Research Objective: The overarching goals of research in the Department of Psychiatry are to increase our understanding of the determinants of psychiatric illness, the mechanisms which contribute to the development of mental illness, and to develop more effective interventions to reduce the burden of mental illness. Current Major Areas of Research : The Department of Psychiatry supports major research programs in multiple fields including schizophrenia, mood disorders, geriatric psychiatry, child psychiatry, forensic psychiatry, psychotherapy, women’s mental health, addictions, neuroscience, psychosomatic medicine, health systems, general psychiatry, cultural psychiatry and education. - Text last updated October 2009


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DEPARTMENT: Public Health (Dalla Lana School of), formerly Public Health Sciences



Overall Research Objective : To be at the forefront of public health, population health and health promotion research internationally. This is accomplished by understanding the determinants of population health, measurement of health status, interventions to enhance health of populations and integration of theoretical, methodological and empirical approaches. Current Major Areas of Research :

• Aboriginal and population health • Child and adolescent health • Epidemiology and public health aspects of cancer and other chronic diseases (e.g.

arthritis, diabetes), addictions (e.g. smoking and alcohol), infectious diseases (e.g. HIV/AIDS, influenza), accidents and injuries

• Global public health • Health and aging • Health promotion and disease prevention • Maternal and child health • Methodological research in epidemiology and biostatistics • Occupational and environmental health • Prevention of transmission of HIV/AIDS • Quantitative and qualitative research - Text last updated November 2009


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Total Number of Awards: 185 Primary Appointments 124 On Campus 0 Off Campus 124 Cross Appointments 6 CIHR $788,057 Tenured 0 NSERC $50,464 Tenure-stream 0 NCIC $463,810 Career Awards 3 HLTH CAN $0 With Research Funds MOH $60,375 Primary Appointments 22 HSFO/C $0 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $1,953,487 Supervised by Primary Appt 108 Other Sources $6,422,005 Fellows: Post-Doc. and Clin. 30

Overall Research Objective : Excellence in clinical and translational, basic science, and physics and imaging research related to radiation medicine. Current Major Areas of Research : • Image guided radiation therapy • Molecular radiation biology of tumour and normal tissues • Clinical trials • Drug-radiation interactions • Tumour microenvironment and treatment outcome • Health services and outcomes research For more information about the Department of Radiation Oncology contact: Dr. Anthony Fyles 416-946-6522 [email protected] - Text last updated October 2009


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Total Number of Awards: 154 Primary Appointments 11 On Campus 11 Off Campus 0 Cross Appointments 6 CIHR $466,601 Tenured 6 NSERC $29,789 Tenure-stream 1 NCIC $0 Career Awards 3 HLTH CAN $0 With Research Funds MOH $0 Primary Appointments 11 HSFO/C $92,328 Cross Appointments unk SSHRC $112,835 Studentship Awards: Industry $75,002 Supervised by Primary Appt 128 Other Sources $1,501,886 Fellows: Post-Doc. and Clin. 1

Overall Research Objective : To advance knowledge of the neurological, behavioural, and social aspects of communication and swallowing. There are two primary foci: normal and disordered speech and swallowing, and language development and disorders across the lifespan. Research linkages have been forged through collaborative projects with engineering, neurol imaging, dentistry, linguistics, psychology and otolaryngology among others. Another research objective is to develop improved models of clinical management of communication disorders. Clinical research is being undertaken in the areas of augmentative and alternative communication, speech fluency, developmental language disorders, hearing loss, aphasia and apraxia of speech, normal speech production, swallowing, modelling of the tongue and vocal tract, neurodegenerative diseases and models of supervision, among others. Current Major Areas of Research : Members of the Department of Speech-Language Pathology pursue research in the following major areas, each represented by a contact person identified below. For more information about our three graduate programs(MHSc., MSc., Ph.D.) and a detailed list of faculty and their research, please inquire at the Rehabilitation Sciences Building, 10th Floor. (or vist our website: www.slp.utoronto.ca) Motor speech disorders and swallowing C. Steele 978-8330 Developmental speech and language disorders L. Girolametto 978-3353 Acquired language disorders (aphasia and dementia) E. Rochon 978-8332 Voice and resonance disorders T. Bressmann 978-7088 Speech motor control and stuttering L. De Nil 978-1789 Augmentative and alternative communication and ALS Y. Yunusova 978-6890 Developmental speech and language disorders C. Johnson 978-8331 Speech physiology and speech motor control P. Van Lieshout 978-8334 Childhood hearing loss A. Eriks-Brophy 946-8633 Swallowing R. Martino 946-8644 Stuttering R. Kroll 978-1789 International Rehabilitation P. Parnes 946-8556 Aphasia Treatment Outcomes A. Kagan 978-2770 Auditory Physiology J. Mendelson 978-2770 Literacy and Treatment Outcomes M.Thelander 978-2770 Otolaryngology J. Irish 978-2770 - Text last updated October 2009


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DEPARTMENT: Surgery


Total Number of Awards: 535 Primary Appointments 352 On Campus 7 Off Campus 345 Cross Appointments 60 CIHR $7,451,312 Tenured 3 NSERC $272,838 Tenure-stream 0 NCIC $916,199 Career Awards 19 HLTH CAN $0 With Research Funds MOH $486,286 Primary Appointments 129 HSFO/C $1,805,657 Cross Appointments unk SSHRC $0 Studentship Awards: Industry $2,519,489 Supervised by Primary Appt 149 Other Sources $19,923,766 Fellows: Post-Doc. and Clin. 184


World countries) - Text last updated October 2009


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48








49



Total Number of Awards: 47 Research Funds 20 Career Awards 1 CIHR $1,602,149 Studentship Grant Awards: NSERC $56,000 NCIC $0 Supervised by Investigator 5 HLTH CAN $0 MOH $3,500 Fellows: HSFO/C $1,245,215 SSHRC $0 Post-Doc. and Clin. 6 Industry $149,347 Other Sources $614,881



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Total Number of Awards: 42 Research Funds 10 Career Awards 4 CIHR $14,850 Studentship Grant Awards: NSERC $0 NCIC $0 Supervised by Investigator 5 HLTH CAN $0 MOH $0 Fellows: HSFO/C $0 SSHRC $0 Post-Doc. and Clin. 6 Industry $145,465 Other Sources $3,115,040



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Total Number of Awards: 231 Research Funds 75 Career Awards 13 CIHR $6,582,265 Studentship Grant Awards: NSERC $42,210 NCIC $0 Supervised by Investigator 38 HLTH CAN $626,826 MOH $1,657,460 Fellows: HSFO/C $302,254 SSHRC $486,863 Post-Doc. and Clin. 27 Industry $3,280,330 Other Sources $11,995,716



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Total Number of Awards: 601 Research Funds 121 Career Awards 17 CIHR $14,530,463 Studentship Grant Awards: NSERC $290,620 NCIC $3,546,497 Supervised by Investigator 107 HLTH CAN $2,543 MOH $341,267 Fellows: HSFO/C $413,288 SSHRC $0 Post-Doc. and Clin. 105 Industry $6,881,550 Other Sources $40,909,714



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Total Number of Awards: 784 Research Funds 178 Career Awards 31 CIHR $8,246,621 Studentship Grant Awards: NSERC $59,064 NCIC $6,039 Supervised by Investigator 104 HLTH CAN $1,250,869 MOH $2,770,981 Fellows: HSFO/C $1,334,099 SSHRC $19,250 Post-Doc. and Clin. 16 Industry $5,994,860 Other Sources $20,608,641



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Total Number of Awards: 1 Research Funds 1 Career Awards CIHR $0 Studentship Grant Awards: NSERC $0 NCIC $0 Supervised by Investigator HLTH CAN $0 MOH $0 Fellows: HSFO/C $0 SSHRC $0 Post-Doc. and Clin. Industry $0 Other Sources $10,000



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Total Number of Awards: 386 Research Funds 157 Career Awards 26 CIHR $11,716,101 Studentship Grant Awards: NSERC $183,750 NCIC $2,398,557 Supervised by Investigator 22 HLTH CAN $0 MOH $2,323,207 Fellows: HSFO/C $4,238,979 SSHRC $34,866 Post-Doc. and Clin. 77 Industry $8,175,617 Other Sources $25,294,580







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Total Number of Awards: 93 Research Funds 24 Career Awards 4 CIHR $997,906 Studentship Grant Awards: NSERC $53,054 NCIC $0 Supervised by Investigator 10 HLTH CAN $0 MOH $3,443,719 Fellows: HSFO/C $138,983 SSHRC $0 Post-Doc. and Clin. 22 Industry $2,275,002 Other Sources $4,174,110



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Total Number of Awards: 1159 Research Funds 249 Career Awards 52 CIHR $37,412,377 Studentship Grant Awards: NSERC $520,908 NCIC $5,518,428 Supervised by Investigator 291 HLTH CAN $0 MOH $1,989,704 Fellows: HSFO/C $4,285,422 SSHRC $32,918 Post-Doc. and Clin. 480 Industry $13,020,868 Other Sources $63,641,886



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Total Number of Awards: 50 Research Funds 15 Career Awards 6 CIHR $1,298,183 Studentship Grant Awards: NSERC $0 NCIC $35,000 Supervised by Investigator 5 HLTH CAN $0 MOH $145,850 Fellows: HSFO/C $0 SSHRC $0 Post-Doc. and Clin. 2 Industry $14,090 Other Sources $1,576,695



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Affiliated with the Faculty of Medicine The information contained in this section of the Synopsis describes the multidisciplinary research initiatives of University intra/extradepartmental units affiliated with the Faculty of Medicine. Research funding awarded to intra/extra departmental unit academic staff members is administered through the Faculty of Medicine department to which they are appointed or through the Office of the Vice-Dean Research. Where applicable, the following information is provided: • number of academic staff participating in the unit, • number of non-academic associates, • number of Faculty of Medicine students and fellows affiliated with the unit, • Faculty of Medicine departments, University of Toronto faculties, other universities and


This listing does not encompass the entire set of intra/extra departmental units of the Faculty of Medicine, but only those units who chose to provide information for this 2009 report. The information on the following pages was provided by each individual intra/extradepartmental unit. Any additional inquiries should be addressed to the specific Unit.


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CENTRE: Banting & Best Diabetes Centre Total Membership: 158 (111 of whom are U of T Faculty) Number of Graduate Studentships Awarded in 2008-2009: 24 Number of Postdoctoral Fellowships Awarded in 2008-2009: 7 Participating Departments : • Anaesthesia • Anthropology • Banting & Best Deptartment of Medical

Research • Biochemistry • Chemical Engineering • Faculty of Physical Education & Health • Family & Community Medicine • Health Policy, Management & Evaluation • Institute of Biomaterials & Biomedical

Engineering • Institute of Medical Science

• Immunology • Laboratory Medicine & Pathobiology • Leslie Dan Faculty of Pharmacy • Medical Biophysics • Molecular Genetics • Medicine • Nutritional Sciences • Obstetrics and Gynaecology • Ophthalmology & Vision Sciences • Physiology • Psychiatry • Surgery

Other Participants: • Hospital for Sick Children Research Institute • Samuel Lunenfeld Research Institute • Sunnybrook Research Institute • Toronto General Research Institute • Toronto Western Research Institute • TriHospital Diabetes Education Centre • University Health Network Overall Research Objective: To foster programs of diabetes research, education and patient care at the University of Toronto and its fully and partially affiliated hospitals. To develop an endowment to support the activities of the Centre, and to establish new research programs in areas related to diabetes in a number of clinical and basic sciences departments of the Faculty. Current Major Areas of Research: • Atherosclerosis • Clinical trials • CNS control of metabolism • Complications of diabetes • Diabetic nephropathy • Experimental therapeutics • Genetics of diabetes • Glucagon related peptides • Gut hormones • Immunology of diabetes

• Insulin secretion • Insulin signaling • Integrative biology • Islet biology • Lipoprotein kinetics • Membrane biology • Molecular biology • Molecular genetics and evolution • Pharmacotherapy • Stem cells

- Text last updated January 2010


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CENTRE: Joint Centre for Bioethics The University of Toronto Joint Centre for Bioethics is a partnership among the University of Toronto, Baycrest Centre for Geriatric Care, Bloorview Kids Rehab, Centre for Addiction and Mental Health, Centre for Clinical Ethics, a joint venture of Providence Healthcare, St. Joseph’s Health Centre and St. Michael’s Hospital, The Hospital for Sick Children, Humber River Regional Hospital, Mount Sinai Hospital, North York General Hospital, Sunnybrook Health Sciences Centre, Toronto Community Care Access Centre, Toronto Rehabilitation Institute, Trillium Health Centre and University Health Network (Princess Margaret Hospital, Toronto General Hospital, and Toronto Western Hospital) . The mission of the Joint Centre is to provide leadership in bioethics research, education, practice and public engagement. Students, Research Assistants and Fellows : The Joint Centre for Bioethics has a formal doctoral-stream Collaborative Program in Bioethics through the School of Graduate Studies. The participating graduate units are: Department of Health Policy, Management and Evaluation, Institute of Medical Science, Faculty of Law, Faculty of Nursing, Faculty of Social Work, Graduate Department of Rehabilitation Sciences, Department of Philosophy, Dalla Lana School of Public Health and Department and Centre for the Study of Religion. The Joint Centre for Bioethics also has a professional MHSc degree in Bioethics through the Institute of Medical Science. Participating Departments in the Faculty : Almost all the departments in the Faculty participate in the Joint Centre for Bioethics. There are academic fellowships in clinical and organizational ethics and research grants support fellows, graduate students and research associates and assistants in specific projects. Other Participating Faculties and Departments : Arts and Science, Law, Management, Social Work and Nursing Overall Research Objective : To improve healthcare through interprofessional and interdisciplinary leadership in bioethics research, education, practice and public engagement. Current Major Areas of Research : • Canadian Priority Setting Research Network (CPSRN) • Canadian Program on Research on Ethics in a Pendemic (CanPREP) • Clinical, Organizational and Research Ethics (CORE) Network • Organizational Ethics Research Group • Project to Examine Effectiveness in Clinical Ethics • Public Health Ethics Interest Group • Research and Education in Research Ethics • Rehab and Continuing Care Ethics Research Group • Mental Health Ethics - Text last updated January 2010


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CENTRE: Donnelly Centre for Cellular and Biomolecular Research It is now clear that continued progress in medicine and health research is dependent upon the integration of technology, expertise, and thought from diverse disciplines. This new theoretical architecture presents a challenge which is best addressed through creation of dedicated interdisciplinary centres. The University of Toronto has addressed this challenge through the establishment of the Donnelly Centre, a unique centre in which investigators from the Faculty of Medicine, Pharmacy, Applied Sciences & Engineering, and Arts & Science are brought together in an open, think-tank environment. The Donnelly Centre is mandated to stimulate novel interactions at the interface of biology, chemistry, engineering and computer science in order to develop and apply new technologies for approaching the most challenging biological problems in the post-genomic era. Under the direction of Professor Brenda Andrews, the Centre is overseeing the development of the research programmes by participating in multi-faculty recruitments which will consolidate current strengths and build new ones. Academic Staff : 33 Students & Fellows : Post-Doctoral Fellows 67 Ph.D. Students 169 Research Associates 24 Participating Departments and Units : Faculty of Medicine

• Banting & Best Department of Medical Researchch • Biochemistry • Molecular Genetics • Surgery

Faculty of Applied Sciences & Engineering

• Department of Chemical Engineering & Applied • Department of Electrical & Computer Engineering

Faculty of Arts & Science • Department of Computer Science • Department of Chemistry

Faculty of Pharmacy Institute for Biomaterials & Bioengineering

Overall Research Objective: . The fundamental mandate of the Donnelly Centre is to create a research environment that encourages the integration of biology, computer science, mathematics, engineering and chemistry and that spans leading areas of biomedical research. www.thedonnellycentre.utoronto.ca Current Major Areas of Research:

• Integrative Biology and Technology Development • Bio-engineering and Bioimaging • Models of Disease • Proteomics and Biological Networks • Interdisciplinary Cell Biology • Stem Cell Biology and Engineering • Functional Genomics and Systems Biology • Chemical Genomics

- Text last updated Jan 2010


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CENTRE: Clinical Science Division Academic Staff : 26 Students & Fellows : Graduate Students 43 Post-doctoral & Clinical Research Fellows 23 Participating Departments in the Faculty : • Medicine • Surgery Overall Research Objective : To foster a strong intellectual environment for clinician-scientists and basic scientists to undertake research programs alone, or in collaboration with one of the major research groupings and to provide a superior milieu for the training of research fellows and graduate students. Current Major Areas of Research : • Molecular Medicine Program • Cardiovascular sciences • Gastroenterology • Infectious diseases/HIV • Renal physiology/pathophysiology • Respiratory sciences - Text last updated February 2010


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CENTRE: The Wilson Centre for Research in Education The Wilson Centre for Research in Education www.thewilsoncentre.ca is dedicated to advance healthcare education and practice through research. It is designed to bring together health professional educators, basic scientists, clinical and rehabilitation scientists and community healthcare professionals for the purpose of conducting research aimed at improving curriculum, teaching, learning and evaluation. The overarching mission of the Wilson Centre is to i) foster the discovery and application of new knowledge relevant to advancing healthcare education and practice ii) promote creative synergies between diverse theoretical perspectives and between theory and practice, and iii) be a world leader in education research. Core Academic Staff : 10 Administrative Staff : 4 Clinician/Educator Researchers 21


Participating Departments in the Faculty : • Anaesthesia • Division of Anatomy • Family & Community Medicine • Health Policy, Management & Evaluation • Institute of Medical Science • Medicine • Obstetrics & Gynaecology • Occupational Science & Occupational

Therapy

• Paediatrics • Psychiatry • Public Health Sciences • Medical Imaging • Radiation Oncology • Rehabiliation Sciences Sector • Speech-Language Pathology • Surgery

Other Participating Faculties & Departments : OISE/UT, Library and Information Science, Institute for Medical Science, Standardized Patient Program, Network of Excellence in Simulation for Clinical Teaching and Learning at Mt. Sinai Hospital (NESCTL), Surgical Skills Centre at Mount Sinai Hospital, Centre for Faculty Development at St. Michael’s Hospital, Program in eHealth Innovation, Faculty of Medicine Acadamies; Faculty of Nursing, Faculty of Dentistry, Faculty of Pharmacy, Michener Institute, UoT Centre for International Health, UoT Dalla Lana School of Public Health. Other Participants : Conestoga College Institute of Technology & Advanced Learning, Interprofessional Education at Bridgepoint Health, The Peter A. Silverman Centre for International Health at MSH, Ryerson University, Ontario Medical Schools, Addis Ababa University in Ethiopia, Technion Medical School, Haifa, Israel and Imperial College, London, England. Participating Hospitals : All teaching hospitals affiliated with the University of Toronto. Overall Research Objective : To advance healthcare education and practice through research. Current Major Areas of Research : Programs of research which are drawn from: learners and learning environments and their evaluation and improvement, teachers and teaching evaluation and improvement, informatics in health professional education, interprofessional skills including team work communications, factors affecting diagnostic decision making, the psychometrics of performance-based assessment and the sociology of health professional education research, professionalism and healthcare delivery, computer assisted instruction, clinical and technical skills simulation and assessment, communication skills simulation and assessment, curriculum development and evaluation, interdisciplinary projects in cognitive sciences regarding clinical problem solving, critical thinking and memory, patient safety and medical error, the development of and changes in sciences, Health Sciences Faculties collaborative projects related to educational and practice outcomes of health professional education and faculty development. Prepared: January 25, 2010


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CENTRE: Gage Occupational & Environmental Health Unit Academic Staff : 15 Graduate Students : 30 The Gage Occupational and Environmental Health Unit is a collaborative program of the Department of Medicine and the Dalla Lana School of Public Health at the University of Toronto and the Department of Occupational and Environmental Health at St. Michael’s Hospital. The mission of the Unit is to be a leading academic unit in workplace and environmental health, engaged in innovative research and education programs and services, all aimed at fostering the creation of healthy workplaces and environments. The Unit participates in teaching programs, including the undergraduate medical curriculum, the graduate programs in the Dalla Lana School of Public Health and the Institute of Medical Sciences, the residency program in Occupational Medicine, and the Diploma in Industrial Health. Research activities on effects of occupational and environmental agents, including characterization of exposure and adverse health effects, span the spectrum from basic science through clinical investigation to population-based studies and health services research related to the delivery of occupational health services. The Gage houses the Centre for Research Expertise in Occupational Disease, funded by the WSIB and supported by a multistakeholder Advisory Committee. The Centre has three major program areas, occupational respiratory disease, occupational skin disease and hand arm vibration syndrome. Cross cutting themes include prevention, diagnosis, health services, outcomes, biological agents and the health care sector. Overall Research Objective : To conduct basic and applied research into the causes, diagnosis, treatment and prevention of occupational and environmental health problems. Current Major Areas of Research : • Occupational diseases with focus on occupational asthma, contact dermatitis, hand arm

vibration syndrome including prevention, causation, diagnosis, return to work and outcomes • Development and evaluation of methods for exposure assessment and characterization • Development and evaluation of methods for creation of exposures for chamber studies • Role of air contaminants in lung injury and inflammation Text last updated January 2010


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CENTRE: Centre for Health Promotion (1990-2009)

Academic Staff : 3 Non-Academic Associates :30 Academic Associates : 6 Students : 6 PostDoctoral Fellows: 0 Studentship Awards: N/A Participating Departments in the Faculty : • Dalla Lana School of Public Health Other Participants: Other Participating Faculties & Departments: Participating Organizations : • Centre for Addiction & Mental Health • Promotion & Programs Branch, Ontario Regional Office, Public Health Agency of Canada • Health Nexus • Ministry of Health Promotion • Toronto Public Health • Centre for Urban Health Initiatives • Centre for International Health • Canadian Society for International Health • IUHPE-International Union of Health Promotion and Education • PAHO-Pan American Health Organization • WHO-World Health Organization Overall Research Objective : To develop a program of applied evaluation research in health promotion provincially, nationally and internationally. Major Areas of Research : • Youth friendly primary health services • Mental health promotion • Evaluation of Healthy Settings • Economic Evaluation in health promotion • First Peoples’ Health Promotion The Centre for Health Promotion was closed on July 15, 2009 and its activities were folded into the Health Promotion Program in the Dalla Lana School of Public Health. - Text last updated January 2010


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CENTRE: Centre for International Health, Dalla Lana School of Public Health

Centre for International Health, Dalla Lana School of Public Health is committed to advance global health research and education at the Dalla Lana School of Public Health, across the University of Toronto with national and international partners. CIH promotes, facilitates global health research, education and advocacy. Collaborations continue with the Centre for Global Health Research at St. Michael’s Hospital, Office of International Surgery, Sickkids International, the Global Pediatric Research Program, the MAA/CIH overseas research elective program and the International Centre for Disability and Rehabilitation. It enables and facilitates ideas, research and education to advance the University’s research priority. During 2008-2009 the CIH continued its five year Association of Universities and Colleges of Canada(AUCC) /CIDA funded (Tier 2) collaboration with the University of Port Harcourt, Nigeria to research on and develop human resources needed to combat HIV/AIDS; continued research on rural health system reform through collaborations with the China National Health Economics Institute and Kunming Medical College; collaboration with Capital Medical University in Beijing to study and implement the teaching of family/general practice medicine; and facilitated student initiated primary health care research in Cambodia, at its field station program in Kep and in hospitals in the capital city, Phnom Penh. The CIH has recently hosted graduate students in public health from Moi University, Kenya and a doctoral students from Fudan University and Capital Medical University, China. Participating Departments and Units in the Faculty of Medicine (selected): • Health Policy, Management & Evaluation • Family and Community Medicine • Otolaryngology • Pediatrics • Psychiatry Rehabilitation Sciences • Surgery • Obstetrics and Gynaecology • Medicine & Infectious Disease & Emergency • Microbiology • Continuing Education • Joint Centre for Bioethics • Centre for Health Promotion • Centre for Research in Women’s Health Other Multidisciplinary Collaborations (selected) : • Faculty of Physical Education and Health • Faculty of Dentistry • Faculty of Arts and Science • New College • University College • Faculty of Pharmacy • Faculty of Law • Faculty of Social Work • Faculty of Engineering Overall Research Objective: Facilitating multidisciplinary research focused on health challenges affecting the world’s most vulnerable populations. Current Areas of Research: • Primary Health Care Development – Cambodia (2008-2009) • Rural Health System Reform – China (2008-2009) • Urban Community Health Development - China (2008-2009) • HIV/AIDS –Zambia, Namibia,Tanzania, Nigeria and Kenya; South Africa, Ethiopia and Malawi • Global Health Education for Medical Residents: Global Health Education Institute

With Medical Alumni Association funding and collaboration, the CIH manages international student research and elective opportunities. Visit: www.cih.utoronto.ca - Text last updated: February 2010


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CENTRE: R.S. McLaughlin Centre for Molecular Medicine The R. Samuel Mclaughlin Centre for Molecular Medicine (MCMM) was established with a vision of improving health through the application of molecular advances to clinical care. Founded with a 50 million dollar endowment matched by institutional partners, the Centre is a joint initiative of the University of Toronto and four affiliated hospital-based research institutions: the Hospital for Sick Children, Mount Sinai Hospital, University Health Network, and Sunnybrook and Women’s College Health Sciences Centre. The Centre seeks to become a global leader in translational research by attracting the best and brightest scientists who share in, and wish to realize, this vision. Under the direction of Dr. Keith Stewart research efforts at the MCMM have been organized into four distinct program groupings. These four programs are Molecular Therapeutics, Global Health, Computational Genomics and Regenerative Medicine. Academic Staff : 41 Participating Departments and Units : • Biochemistry • Biochemistry and Structural Biology • Chemical Engineering and Applied


Engineering






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CENTRE: Centre for Research in Neurodegenerative Diseases Academic Staff : 12. Post-Doctoral Fellows 16 + 2 Visiting Scientists Ph.D. Students 7 Research Associates 3 Current Major Areas of Research : • Alpha-synuclein biochemistry • Amyloid neurotoxicity • Vertibrate and invertibrate animal models of Alzheimer’s Disease, Frontotemporal lobar

degenerations, ALS, Parkinson’s Disease • Brain trophic factors and neuron rescue • Cytoskeletal proteins in health and neurodegenerative disease • Gene expression in Alzheimer's Disease • Genetic basis of familial neurodegenerative disease • Genetics of Amyotrophic Lateral Sclerosis (Lou Gehrig’s Disease) • Genetics of Parkinson’s Disease • Genetics of spinocerebellar ataxias • Pharmacokinetics of anti-dementia drugs • Protein structure, protein-protein interactions • Molecular and cell biology of amyloid, α-synuclein, tau, progranulin, TBP43, peripherin • Developmental neurobiology • Axon guidance and sprouting - Text last updated February 3, 2010


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INDUSTRIAL FUNDING SOURCES We would like to acknowledge the sponsorship of our industrial partners. Total grants received: Greater than $1,000,000 Abbott Laboratories Ltd. Dan Haag MGX Hoffmann-La Roche Ltd. Lundbeck Canada Inc Merck Frosst Canada Ltd. Novo Nordisk A/S

Pfizer Canada Inc. Respironics, Inc. Sanofi-Aventis (Canada) Structural Genomics Consortium The Freedom Forum

Between $500,000 and $999,999 AAMGEN Inc. AstraZeneca Canada Inc. Bayer Inc. Boehringer Ingelheim Pharmaceuticals Inc. Bristol-Myers Squibb Pharmaceutical Group

(Canada)

Duchesnay Inc. GlaxoSmithKline Inc. ITI Scotland Limited Janssen-Ortho Inc. (Canada) Novartis Pharmaceuticals Canada Inc. Schering Canada Inc..

Between $200,000 and $499,999 AMGEN Canada Inc. Aegera Therapeutics Inc Allergan Inc. Astellas Pharma Canada, Inc. Aventis Pasteur Ltd. Aviva Canada Inc BioMs Technology Corporation Biogen Idec, Inc. Burroughs Wellcome Fund CSL Limited Celgene Corporation Eastman Kodak Company Elekta Instrument AB Elekta Ltd.

Eli Lilly Canada Inc. Guidant Canada Lovelace Biomedical & Environmental Research

Institute Maquet - Dynamed MedBiogene PPD Development, Inc. Pfizer Inc. Philips Electronics North America Corporation Sangamo Biosciences Inc VistaGen Therapeutics Inc Wyeth-Ayerst Canada Inc. YYZ Pharmatech Inc...

Between $100,000 and $199,999 ARIUS Research Inc. Baxter Healthcare Corp (Canada) BioMimetic Pharmaceuticals Inc Boehringer Ingelheim (Canada) Ltd. Boston Scientific Corporation Bristol-Myers Squibb Foundation Inc. Charles River Laboratories International, Inc. EntreMed, Inc. Genentech, Inc. Gilead Sciences Institut Rosell, Inc. Integrated BioTherapeutics Limited International Consortium on Anti-Virals Johnson & Johnson Marine Polymer Technologies Millennium Pharmaceuticals Inc. Northern Therapeutics Inc. Ontario Power Generation Inc.

OrbusNeich Osiris Therapeutics Inc Panacis Medical Procter & Gamble Pharmaceuticals Canada, Inc. Proteolix Inc. RaySearch Medical AB Sandler Program for Asthma Research Saskatchewan Pulse Growers Sepsis Inc. Shire Pharmaceuticals Signal Pharmaceuticals, LLC Smith & Nephew (Canada) Solvay Pharmaceuticals B.V. St. Jude Medical Canada, Inc. Stryker Canada Synthes Spine Company The Multiple Myeloma Research Foundation Ventana Medical Systems Inc


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Less than $100,000 Abbott Laboratories Ltd. Abbott Vascular Inc. Acorda Therapeutics Inc. Actelion Pharmaceuticals Canada Inc. Actelion Pharmaceuticals Ltd Advanced Neuromodulation Systems Alcon Inc. Allon Therapeutics Incorporated Alnylam Pharmaceuticals Inc Altus Pharmaceuticals Inc. Amorfix Life Science Ltd. Anthera Pharmaceuticals Inc Ardea Biosciences Arena Pharmaceuticals Inc Axio Research Company Back2Feet Inc. Bell Canada Berlex Canada Inc. BioCardia, Inc. Bioniche Therapeutics Limited Biorthex Inc. Bristol-Myers Squibb Canada Inc. CSL Behring Cascade Therapeutics Inc. Cephalon ChemGenex Pharmaceuticals Inc ChemoCentryx Inc Cook (Canada) Inc. Cordis Corporation Cyclacel Ltd Edwards Lifesciences LLC. Eisai Medical Research Inc. Eli Lilly and Company Encysive Pharmaceuticals Inc Epix Pharmaceuticals, Inc. Exelixis Inc Ferring Pharmaceuticals Inc. Field Metrica Inc. FoldRx Pharmaceuticals, Inc. Fresenius Kabi Deutschland GmbH GE Healthcare Gemin X Biotechnologies Inc. GeneNews Inc. GeneOhm Sciences, Canada Inc. Genzyme Corporation Genzyme Corporation Genzyme Japan GlaxoSmithKline (Canada) GlaxoSmithKline Inc. Glycaemic Index Testing Inc. H. Lundbeck A/S H.J. Heinz Company of Canada Ltd. Hana Biosciences Inc Hemosol Inc. Hesperion US Inc

Hoffmann-La Roche Inc. (Canada)?? Infinity Pharmaceuticals Inc Innovotech Inc Inspire Pharmaceuticals Inc Intercept Pharmaceuticals Inc Intercytex Ltd Isotechnika Inc. John E. Fetzer Institute, Inc. KWF Kankerbestrijding Kellogg Company Kinetic Concepts, Inc. KuDOS Pharmaceuticals Ltd. LISI Therapeutics Lexicon Pharmaceuticals Inc. Litebook Company Ltd Luminex Molecular Diagnostics Lupus Clinical Trials Consortium, Inc. MDS Health Group Limited MDS Pharma Services MGI Pharma, Inc. MannKind Corporation Masimo Corporation MedPharmGene Inc. Medicork Ltd Medicure, Inc. Medpace Inc. Medtronic Inc. (US) Medtronic MiniMed Inc Medtronic of Canada Ltd. Merck & Co., Inc. Metabolic Pharmaceutical Limited MethylGene Inc. Microvention Inc Momenta Pharmaceuticals Myconostica Ltd NDO Surgical, Inc. NPS Pharmaceuticals Inc Nanogen, Inc. NeuroProtection, Inc. New England Research Institutes NoNO Inc Nova Biomedical Corporation NovaLung GmbH Novartis Institute for Biomedical Research Novartis International AG Novartis Pharmaceuticals Corporation Novartis Pharmaceuticals Corporation Nycomed Canada Inc. Open Biosystems, Inc. Optimer Pharmaceuticals Ortho Biotech, a Division of Jansenn-Ortho Inc. Ortho-Clinical Diagnostics Otsuka America Pharmaceutical Inc. PAREXEL International Paracor Medical Inc


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Less than $100,000 (continued) Pharmaxis Ltd Pharmena North America Inc Predictek Inc Protalix Ltd Proteomic Methods Inc Purdue Pharma L.P. QLT Inc. Response Biomedical Corporation Sanofi-Synthelabo Inc. Sanofi-Synthelabo Inc. Servier Canada Inc. Shire Human Genetic Therapies Inc Shire Pharmaceuticals Group plc Siemens Medical Solutions Solae, LLC Sorin Group St. Jude Medical, Inc. StemCell Tecnologies Inc. Sucampo Pharmaceutical Inc Summit Technologies Sun Microsystems of Canada Inc.

SuperGen, Inc. Synthes (Canada) Ltd. Taiji Bio Medical Inc Talecris Biotherapeutics, Inc. Teva Neuroscience, Inc. The Emmes Corporation The Health Technology Exchange Thoratec Corporation Tibotec Pharmaceuticals Ltd. Transkaryotic Therapies, Inc. Trillium Therapeutics Inc. Tyco Healthcare Group LP UCB Pharma Unilever UK Central Resources Ltd United Paragon Associates Inc. Vicuron Pharmaceuticals Inc. ViroPharma Inc Wyeth Xceed Molecular Corporation ZOLL Medical Corporation Zimmer of Canada Ltd.


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Total grants received: Greater than $1,000,000 Bill & Melinda Gates Foundation Bloorview Childrens Hospital Foundation CANADA FOUNDATION FOR INNOVATION CANADA RESEARCH CHAIRS PROGRAM Canadian Breast Cancer Foundation Canadian Breast Cancer Research Alliance Canadian Cancer Society Canadian Cystic Fibrosis Foundation Canadian Diabetes Association Cancer Care Ontario Crohn's & Colitis Foundation of Canada Do not List - Argonne National Laboratory (NIH

Sub-grant) Fondation Leducq Government of Canada: Canada Research Chairs Government of Canada: Canadian International

Development Agency Government of the United States: National

Institutes of Health (US) Hospital for Sick Children Hospital for Sick Children Foundation Howard Hughes Medical Institute John P. Robarts Research Institute Juvenile Diabetes Research Foundation

International Leukemia & Lymphoma Society McMaster University

Ministry of Health Promotion Ministry of Research and Innnovation (Ontario) Mount Sinai Hospital Mount Sinai Hospital Foundation Multiple Sclerosis Society of Canada Networks of Centres of Excellence: Canadian

Arthritis Network (CAN) Networks of Centres of Excellence: Stem Cell

Network (SCN) Northwestern University ONTARIO INNOVATION TRUST Ontario Cancer Institute Ontario Genomics Institute Ontario Institute for Cancer Research Ontario Mental Health Foundation Ontario Neurotrauma Foundation Physicians' Services Inc. Foundation St Michael's Hospital St. Michael's Hospital Sunnybrook & Women's College Health Sciences

Centre The Ontario HIV Treatment Network UOFT University Health Network Workplace Safety and Insurance Board various companies various sponsors

Between $500,000 and $999,999 Anonymous Arthritis Society Canadian Health Services Research Foundation Genomics Ontario Inc Government of Canada: The Public health

Agency of Canada Government of the United States: National

Institute on Alcohol Abuse and Alcoholism Government of the United States: Office of Army

Research Hamilton Health Sciences Corporation

Kidney Foundation of Canada McGill University McLaughlin Centre for Molecular Medicine NCE: PrioNet Networks of Centres of Excellence: Canadian

Stroke Network (CSN) Ontario Problem Gambling Research Centre Province of Ontario The Susan G. Komen Breast Cancer Foundation

Between $200,000 and $499,999 AOSpine North America Alzheimer Society of Canada Alzheimer's Association Amyotrophic Lateral Sclerosis Association (US) Autism Speaks B.r.a.i.n. Child BioDiscovery Toronto Bloorview Kids Foundation

Canadian Association of Gastroenterology Canadian Blood Services Canadian Chiropractic Protective Association Canadian Foundation for AIDS Research

(CANFAR) Canadian Institute of Ukrainian Studies Cancer Research Society Inc. Case Western Reserve University


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Between $200,000 and $499,999 (continued) Columbus Children's Research Institute Connaught Fund, internal funding Crohn's & Colitis Foundation of America, Inc. Cystic Fibrosis Foundation Desmoid Tumor Research Foundation Eye Institute of Canada Genome Prairie Inc. George Washington University Government of Canada: Canada Mortgage and

Housing Corporation Government of Canada: International


Government Services Canada Government of the United States: Office of Army

Research Human Frontier Science Program Organization Krembil Foundation MaRS Discovery District March of Dimes Birth Defects Foundation (U.S.) McEwen Centre for Regenerative Medicine Medical College of Wisconsin Mental Health Commission of Canada Mount Sinai Hospital NCE: Allergy, Genes and Environmental Network National Alliance for Research on Schizophrenia

and Depression

Networks of Centres of Excellence: Advanced

Foods and Materials Network (AFMNet) Networks of Centres of Excellence: Mathematics


Neuroradiology Education And Research Foundation

ONTARIO INNOVATION TRUST ONTARIO RESEARCH AND DEVELOPMENT

CHALLENGE FUND Ontario Centres of Excellence Ontario Hospital Association Ontario Thoracic Society Ottawa Health Research Institute Parkinson Foundation of Canada Prostate Cancer Research Foundation of Canada RSNA Research and Education Fund RUTGERS - STATE UNIVERSITY OF NEW J State University of New York The Arthritis Community Research and Evaluation The Breast Cancer Research Foundation The EJLB Foundation The WB Family Foundation Toronto Rehabilitation Institute Universite de Montreal University of British Columbia University of Guelph University of Houston Vanderbilt University

Between $100,000 and $199,999 Alex's Lemondate Stand Foundation American Health Assistance Foundation Association of Hemophilia Clinic Directors of

Canada Brain Tumor Society CANADIAN INSTITUTES OF HEALTH

RESEARCH Canadian Association for the Study of the Liver Canadian Association of Radiation Oncologists Canadian Institute for Advanced Research Canadian Liver Foundation Canadian Patient Safety Institute Canadian Tobacco Control Research Initiative Children's & Women's Health Centre of British

Columbia Children's Hospital of Eastern Ontario Columbia University New York Craig H. Neilsen Foundation Dairy Farmers of Canada Foundation Fighting Blindness Foundation for Digestive Health and Nutrition

(AGA)

Government of Canada: Department of National Defence: Defence Research & Development Canada


Harvard University Institute of Human Development is included in

CIHR Juvenile Diabetes Research Foundation Canada King Saud University Lymphoma Foundation Canada Macula Vision Research Foundation Multiple Myeloma Research Consortium Muscular Dystrophy Association (US) Networks of Centres of Excellence: Canadian

Institute for Photonic Innovation (CIPI) Ontario Centres of Excellence: Communications

& Information Technology Ontario (CITO) Princeton University Prostate Cancer Research Foundation of Canada Queen's University Retinoblastoma Solutions Rett Syndrome Research Foundation Rick Hansen Foundation


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Between $100,000 and $199,999 (continued) Royal Le Page Shelter Foundation Sloan-Kettering Institute for Cancer Research Stanford University The American Society of Nephrology The Foundation Fighting Blindness - Canada The Hospital for Sick Children Psychiatry

Endowment Fund The James S. McDonnell Foundation The Michael J. Fox Foundation for Parkinson's

Research The Pediatric Brain Tumor Foundation of the

United States

The Provincial Centre of Excellence for Child and

Youth Mental Health The Rockefeller Foundation The Royal College of Physicians and Surgeons of

Canada University of California, San Franc University of Cambridge University of Chicago University of North Carolina (CH) University of Pennsylvania Women's College Hospital Foundation

Less than $100,000 ALS Society of Canada Accupuncture Foundation of Canada Institute Alaska Native Tribal Health Consortium Alberta Health Services Alberta Heritage Foundation for Medical

Research Allen Institute for Brain Science Amalgamated Transit Union MS American Association of Neurological Surgeons American Brain Tumor Association American College of Gastroenterology American College of Radiology American College of Surgeons American Health Assistance Foundation American Institute for Cancer Research American Physiological Society American Society of Colon & Rectal American Speech/Language/Hearing American Surgical Association Foundation Anesthesia Patient Safety Foundation Arbeitsgemeinschaft Fur Osteosynthesefragen -

Association for the Study of Internal Fixation Associated Medical Services, Inc. Auditor General of Alberta Banting & Best Diabetes Centre, internal sponsor Barbara Keenan Foundation Beatty is an internal sponsor Benaroya Research Institute at Virginia Mason Brain Aneurysm Foundation Brain Tumor Foundation of Canada Broad Foundation (Medical) Bruyere Continuing Care C.R. Younger Foundation C17 research Network CIHR : Institute of Infection CIHR: Institute of Musculoskeletal Canadian Agency for Drugs and Technologies in

Health Canadian Anaesthetists' Society Canadian Association of Emergency Physicians Canadian Centre on Substance Abuse

Canadian Child Health Clinician Scientist Program

Canadian Dermatology Foundation Canadian Foundation for Dietetic Research Canadian Foundation for Women's Health Canadian Gene Cure Foundation Canadian HIV Trials Network Canadian Institute for Health Information Canadian Institutes of Health Research: Institute

of Aging Canadian Lung Association Canadian Lung Transplany Study Group Canadian Memorial Chiropractic College Canadian Psychiatric Research Foundation Canadian Urologic Oncology Group Canadian Urological Association Cancer Research Institute (US) Cancer Research and Prevention Foundation Centre Hospitalier de L'Universite de Montreal Centre for Addiction and Mental Health Centrum Foundation Cervical Spine Research Society Child and Youth Health Research Network Childhood Cancer Foundation Children's Hospital Los Angeles Children's Hospital of Philadelphia Children's Memorial Research Center Children's National Medical Center Children's Rehabilitation Research Network Christopher Reeve Paralysis Foundation Christopher and Dana Reeve Foundation Cincinnati Children's Hospital Medical Center College of Family Physicians of Canada Colon Cancer Canada Congress of Neurological Surgeons Cornell University Council of Ontario Universities CureSearch Children's Oncology Group Dairy Farmers of Ontario Dalhousie University Dana-Farber Cancer Institute


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Less than $100,000 (continued) Duke University Dystonia Medical Research Foundation E.A. Baker Foundation of the CNIB European Fdn. for the Study of European Hematology Association (Netherlands) Evanston Northwestern Healthcare Research

Institute Fight for Sight Fonds de la Recherche en Sante du Fowler Kennedy Sport Medicine Clinic Fragile X Research Foundation of Canada France-Canada Research Foundation Glaucoma Research Society Government of Canada: Agriculture and Agri-

Food Canada Government of Canada: Canadian Heritage Government of Canada: Citizenship &

Immigration Canada Government of Ontario: Ministry of Community

and Social Services Government of Ontario: Ministry of Energy Government of Ontario: Ministry of Natural

Resources Government of Ontario: Ministry of the Attorney

General Government of the United States: Department of

Veterans Affairs Haliburton Kawartha Pine Ridge District Health

Unit Hamilton Public Health Unit Head and Neck Cancer Foundation Hospital for Sick Children ICON Clinical Research IWK Health Centre Inactive - COE: Manuf Res Corp Ont Infectious Diseases Society of America Institut Universitaire de Geriatrie de Montreal Institute for Clinical Evaluative Sciences Institute for Developmental Research - AICHI

Human Service Center International Council on Amino Acid Science International Institute for Research in Paraplegia International Society of Heart & Lung

Transplantation J.P. Bickell Foundation Johns Hopkins University Kidneeds Kinark Child and Family Services Lakehead University Lawson Foundation Lawson Health Research Institute Le Hopital Sainte-Justine Leeds Grenville and Lanark District Health Unit London Health Sciences Centre Lupus Ontario

Mach-Gaensslen Foundation of Canada Massachusetts General Hospital Mayo Foundation Medical Council of Canada Medical University of South Carolina Memorial University of Newfoundland Mizutani Foundation for Glycoscience Molly Towell Perinatal Research Fdn Mount Sinai School of Medicine Muscular Dystrophy Association of Canada National Brain Tumor Foundation National Center for Child Health and

Development National Childhood Cancer Foundation National Health and Medical Research Council Network of Excellence in Simulation for Clinical

Teaching Networks of Centres of Excellence: Automobile of

the 21st Century (AUTO 21) Networks of Centres of Excellence: Canadian


Neurosurgery Research and Education Foundation

New Brunswick Health Ohio State University Research Foundation Ontario Centres of Excellence: Photonics

Research Ontario (PRO) Ontario Federation of Indian Ontario Health Quality Council Ontario Lupus Association Ontario Respiratory Care Society Ontario Shared Services OsteoArthritis Research Society International Osteosynthesis & Trauma Care Foundation Otsuka Mayland Research Institute Ovarian Cancer Canada PREMIER'S RESEARCH EXCELLENCE AWARD Physiotherapy Foundation of Canada Prince Edward Island Dept of Health Private Individuals Regional Municip./ Ottawa-Carleton Regional Municipality of Durham Regional Municipality of York ResMed Foundation Rheuminations Inc Royal Women's Hospital Ryerson University Savoy Foundation Society of Cardiovascular Anaesthesiologists South Africa Medical Research Council South East Toronto Stroke Network St Joseph Health Centre St Joseph's Health Care Surgical Infection Society


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Less than $100,000 (continued) Terry Fox Foundation Thalassemia Foundation of Canada The American Society of Clinical Oncology The American Society of Echocardiography The Atkinson Charitable Foundation The Banting Research Foundation The Canadian Chiropractic Research Foundation The Dr. Charles H. Best Foundation The Francis Families Foundation The Gorbachev Foundation of North America The Jarislowsky Foundation The Montreal General Hospital The National Surgical Adjuvant Breast and Bowel

Project (NSABP) The Ontario Council on Graduate Studies The Ontario Tobacco Research Unit The Ottawa Hospital The Sanfilippo Children's Research Foundation The Scottish Rite Charitable Foundation The Sir Jules Thorn Charitable Trust The Society for Gynecologic The Wellesley Institute The Workers' Compensation Board of British

Columbia Thrasher Research Fund Trent University US Immunodeficiency Network United BioSource Corporation Universite Laval Universite de Shrebrooke University Health Network University Renal Research and Education

Association

University of California - Irvine University of Cincinnati University of Colorado University of Dundee University of Iowa University of Manitoba University of Massachusetts University of Medicine and Dentistr University of Miami University of Michigan University of Minnesota University of P.E.I. University of Pittsburgh University of Saskatchewan University of Sherbrooke University of Tromso University of Washington University of Waterloo University of Western Ontario Universtiy of Kansas Medical Center Research

Institute Various Sponsors Virginia Commonwealth University Washington Red Raspberry Commission West Park Hospital Foundation World Health Organization Yale University York University


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Less than $100,000 (continued) Government of Ontario: Ministry of Agriculture and Rural Affairs Government of Ontario: Ministry of Energy Government of Ontario: Ministry of the Attorney General Government of Ontario: Ministry of the Environment Government of the United States: Department of Agriculture Government of the United States: Department of Veterans Affairs Harvard University Head and Neck Cancer Foundation Heart Failure Society of America Henrietta Banting Memorial Fund Henry White Kinnear Foundation Higher Education Commission of Pakistan ICON IWK Health Centre Imperial College London Inner City Health Associates Inst. for Clinical Eval. Sciences Institute for Work & Health Institute of Environmental Science and Research Limited International Institute for Research in Paraplegia International Society of Blood Transfusion Foundation International Society of Heart & Lung Transplantation Jewish Gen Hosp, McGill-CIHR Lakeridge Health London Health Sciences Centre Lupus Canada Lymphoma Foundation Canada Macula Vision Research Foundation Maternal and Child Health Bureau Mayo Medical School McEwen Centre for Regenerative Medicine Medical Council of Canada Medical Univ of South Carolina Mesothelioma Foundation Montana State University Montreal Heart Institute Mount Sinai School of Medicine Multiple Myeloma Research Consortium Muscular Dystrophy Association of Canada National Brain Tumor Foundation National Parkinson Foundation Inc. Natl Net Environ and Women's Health Networks of Centres of Excellence: Canadian Language & Literacy Research Network (CLLRNet) Networks of Centres of Excellence: Canadian Network for Vaccines and Immunotherapeutics

Neurosurgery Research and Education Foundation Neutropenia Support Association Inc New Hope Foundation North American Society For Pediatric Gastroenterology, Hepatology and Nutrition Northeast Mental Health Centre Obsessive Compulsive Foundation Ontario Association of Medical Laboratories Ontario Cancer Biomarker Network Ontario Clinical Oncology Group Ontario Federation Cerebral Palsy Ontario Lung Association Ontario Lupus Association Ontario Ministry of Community Safety and Correctional Services Ontario Public Health Association Ontario Respiratory Care Society Ontario Tobacco Research Unit Org of Teratology Info Specialists Ortho Trauma Association Otsuka Mayland Research Institute PREMIER'S RESEARCH EXCELLENCE AWARD Physiotherapy Foundation of Canada Prostate Cancer Research Foundation Providence Health Care Society Quinte Health Care Corporation ResMed Foundation Rett Syndrome Research Foundation Rheuminations Inc Royal Society of Canada Royal Victoria Hosp of Barrie Foundation Royal Women's Hospital Ryerson University Savoy Foundation Scleroderma Society Of Ontario Shriners Hospitals for Children - Canada Society of Cardiovascular Anaesthesiologists Society of Obstetricians and Gynaecologists of Canada South Africa Medical Research Council St Joseph Health Centre St Joseph's Health Care St. Baldrick's Foundation Sunray Diabetes Foundation Thalassemia Foundation of Canada The American Society of Clinical Oncology The American Society of Nephrology The Atkinson Charitable Foundation The Canadian Chiropractic Research Foundation The Dr. Charles H. Best Foundation The Drummond Foundation The Francis Families Foundation The Gorbachev Foundation of North America The Hearing Foundation of Canada


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Less than $100,000 (continued) The James H. Cummings Foundation Inc. The James S. McDonnell Foundation The Jarislowsky Foundation The Leukemia & Lymphoma Society of Canada The Lustgarten Foundation for Pancreatic Cancer Research The Montreal General Hospital The National Multiple Sclerosis Society The National Surgical Adjuvant Breast and Bowel Project (NSABP) The Ontario Council on Gradual Studies The Ottawa Hospital The Pediatric Oncology Group of Ontario The Princess Margaret Hospital Foundation The Sanfilippo Children's Research Foundation The Scottish Rite Charitable Foundation The Tema Conter Memorial Trust The Workers' Compensation Board of British Columbia Thrasher Research Fund Toronto Centre for Antimicrobial Research & Evaluation Toronto Transit Commission Tourette Syndrome Association (US) Town of Oakville

United Mitochondrial Disease Founda Univ of Ottawa Heart Institute University of Colorado University of Dundee University of Florida University of Maryland University of Medicine and Dentistr University of Miami University of Missouri University of North Carolina (CH) University of P.E.I. University of Texas at Dallas University of Victoria University of Washington University of Waterloo Unknown sponsor Various Sponsors Various Sponsors Washington University St Louis Wayne State University Wellesley Central Health Corporation West Park Hospital Foundation WorkSafe BC Workers Compnesation Board of Manitoba World Bank Yale University


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