Synaptic Action
description
Transcript of Synaptic Action
Synaptic Action
Synaptic Potentials:•EPSP•IPSP
Synaptic Potentials
•Excitatory Postsynaptic Potential (EPSP)•triggered by excitatory neurotransmitters•open ligand-gated Na+ channels•allows Na+ to flow inside the cell•causing a slight depolarization of the postsynaptic cell•moves the postsynaptic cell closer to firing an action potential
•Inhibitory Postsynaptic Potential (IPSP)•triggered by inhibitory neurotransmitters•open ligand-gated K+ channels or Cl- channels•allows K+ to flow out of the cell or Cl- to flow inside the cell•causing a slight hyperpolarization of the postsynaptic cell•moves the postsynaptic cell further from firing an action potential
The Battle to -55mV
EPSP
IPSP
Neurotransmitters•Amines
•Quaternary amines•Acetylcholine (ACh)
•Monoamines•Catelcholamines
•Epinephrine (EPI)•Norepinephrine (NE)•Dopamine (DA)
•Indoleamines•Serotonin (5-HT)•Melatonin
•Amino acids•Gamma-aminobutyric acid (GABA)•Glutamate (GLU)•Glycine•Histamine (HIST)
•Neuropeptides•Opioid peptides
•Enkephalins (ENK)•Endorphins (END)
•Peptide Hormones•Oxytocin (Oxy)•Substance P •Cholecystokinin (CCK)•Vasopressin (ADH)•Neuropeptide Y (NPY)
•Hypothalamic Releasing Hormones•GnRH•TRH•CRH
Cholinergic (Ach) System
*
*(PPT)
(BF)
Noradrenergic (NE) System
*
(LC)
Serotoninergic (5-HT) System
Raphe Nuclei *
Dopaminergic (DA) System 1Mesolimbic
Ventral Tegmental Area (VTA)*
Dopaminergic (DA) System 2Mesostriatal
*
Basal Ganglia