Surgery for Gastric and Oesophageal Cancer Cancer Nov 16... · 2017. 1. 4. · Gastric and...
Transcript of Surgery for Gastric and Oesophageal Cancer Cancer Nov 16... · 2017. 1. 4. · Gastric and...
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Surgery for
Gastric and Oesophageal
Cancer
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Trends in cancer mortality,
England and Wales
SMR base 1980
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Oesophago-Gastric Cancer
The National Problem
• 5th commonest malignancy
• 4th commonest cause of death
• 13,500 people in 2010
• 5 year survival - oesophageal 10%
• 5 year survival - gastric 15%
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Oesophago-Gastric Cancer The Local Problem
•North Trent Cancer Network – Population 1.8m
•30 October 2007 – 30 June 2009
•744 cases of oesophagogastric cancer
•155 resections (21%) • 1 year survival
•Resected 77%
•Palliative oncology 34%
•Best supportive care 18%
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Symptoms Physical signs
• Dysphagia
• Vomiting
• GI bleed
• Symptoms of anaemia
• Weight loss
• Dyspepsia
• Reflux
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Epidemiology
• Marked increase in the incidence of lower
1/3 oesophageal and G-O junction
adenocarcinoma in last 20 years
• Corresponding decrease in the incidence in
distal gastric cancer and squamous cell
cancer of the oesophagus.
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Oesophageal Cancer
Aetiology
• Smoking
• Alcohol
• G-O reflux
• Barrett’s oesophagus
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Why?
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Medically fit
No metastases Operate
Resectable
Medically unfit
Metastases Palliate
Unresectable
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Restore Swallowing
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Surgical Approaches
Thoraco abdominal
Left thoracic
Right thoracic (Ivor-Lewis)
McKeown (3-Stage)
Transhiatal
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Oesophageal Replacement
Stomach (+/- pyloroplasty)
Jejunum
Colon (which segment ?)
Which route ?
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Randomised
Resectable Oesophageal Carcinoma SCC / ACA
Chemotherapy
+ Surgery (CS)
Surgery
alone (S)
n=400 n=402
MRC trial OEO2
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Kaplan-Meier curve showing survival from
date of randomisation
p=0.004
CS S
OE 02 Trial
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• Incidence is increasing
• Selection of patients for surgery has improved
• Peri operative mortality rate has fallen
• Expandable metal stents have improved palliative treatment for
unresectable carcinomas
• Use of neoadjuvant treatments may improve survival rates
• Long term outcome for patients with oesophageal carcinoma
remains dismal
Oesophageal Carcinoma Conclusions
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CDH1 Family Tree
Familial Diffuse Gastric Cancer
† 48
† 48 † 39 39 37 36
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Aetiology of Gastric Cancer Napoleon Bonaparte 1769-1821
Diet: Full of salt preserved
foods, very little fruit &
vegetables – common
foods for long military
campaigns
Genetic: father died of
stomach cancer
H.Pylori: Chronic H.Pylori
infection
Pre cancerous changes:
CAG
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Gastric Cancer : Problems
• Late diagnosis
• Few curative
resections
• Low 5 year survival
• High operative
mortality
• Little specialisation
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LAPAROSCOPY
• Peritoneal metastases
• Direct invasion of other organs
• Avoids open / close laparotomy
• Better surgical planning
• Anaesthetic assessment
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DISTAL TUMOURS
•Stenosis
» Surgery
•Bleeding
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Gastric Resections
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Roux-en-Y
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Lymphadenectomy
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MAGIC Trial
UK MRC Adjuvant Gastric Infusional Chemotherapy
E epirubicin 3 cycles pre op
C cisplatin 3 cycles post op
F 5-FU
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MAGIC Trial
1994 - 2000
Chemo & surgery 250
503 patients Surgery 253
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MAGIC Trial
Disease free survival
Chemo-Surgery-Chemo
Surgery
2 years 48% 40%
5 years 36% 23%
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Gastric Cancer - Conclusions
Incidence decreasing
Pre-operative chemotherapy improves survival
Better surgical results in specialist units
Early diagnosis essential
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Complications!
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Pulmonary Complications
• Pain and atelectasis
• Impaired movement of diaphragm
• Extensive lymphadenectomy resulting in a form of
acute pulmonary oedema
• Post chemotherapy/ irradiation bronchiolitis
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Management
• Thoracic epidural combined with morphine PCA
• Early extubation or overnight ventilation?
• CPAP or not?
• Fluid restrict?
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Anastomotic leak
• Early < 72 hours - technical. Re-exploration and
repair
• Late > 1 week reflects local ischaemia +/or tension
in anastomotic site. Manage conservatively.
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Prevention of complications
• Pain control
• respiratory care and physio and nebulisers
• fluid balance
• inotropes versus vasoconstrictors
• nutrition with feeding jejunostomy
• ? Manage on HDU or ITU
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Oesophageal
Carcinoma
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Oesophageal
Carcinoma
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Oesophageal
Carcinoma
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Oesophageal
Carcinoma
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