Supporting immune system
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Supporting Your Innate Immunity
Mark Lange, PhD
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DisclaimerThese statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure or
prevent any disease.
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The Hygiene Hypothesis▪The shift from dirty to sterile has changed our immune response.
▪The idea that sterile is good, sterile is healthy, is being questioned.
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Our Urban Lifestyle Attempts to Eliminate Naturally-Occurring Microbes, Yeasts and Molds
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Exposure to Dirt/Microbes Might Actually Upregulate Immune
Response▪Children going to daycare have fewer asthma and allergies as they grow up.
▪Children living on farms less likely to have asthma and allergies.
▪Growing up in large family gives exposure to viruses and microbes.
▪Breast-fed babies have fewer allergies than bottle-fed.
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Is Getting Dirty the Best Way to Support Natural Immune
Response?
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How Your Immune System Works
▪Creates a barrier that prevents bacteria and viruses from entering body.
▪Your innate (meaning “present from birth”) immune system detects and destroys without needing to be trained to identify the intruders. (FAST)
▪Your adaptive immune system learns. (SLOWER)
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Cells of the Innate Immune System▪Neutrophils are very abundant.▪Attack in large numbers.▪They are the first responders; within minutes.▪Survive only 1-2 days.
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Cells of the Innate Immune System▪Macrophages (“big eaters”) ▪Hang out in lung, gut, mucosal tissue.▪Either “eat” (phagocytize) invaders or▪Give an external oxidative burst to kill invaders.
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Complement▪Is like a chemical red flag, marking pathogens as being “non-self.”
▪Acts as an attractant to innate immune cells, such as neutrophils.
▪Complement also enhances the binding of the pathogen for phagocytosis, enhancing the antimicrobial activities of neutrophils.
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Supporting a Healthy Immune System
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Wellmune®
▪Derived from a proprietary strain of yeast.▪Generally Recognized as Safe (GRAS) and non-allergenic.
▪Effectiveness proven in clinical trials.▪Source of beta glucans, which act as complement to neutrophils.
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How Wellmune® WorksAfter ingestion, Wellmune is absorbed in the GI tract through Peyer’s patches.
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Macrophages Digest Wellmune
Wellmune Wellmune Active Fragments
Enzymes
Slowly released
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Engulfing a Bacterium
Neutrophil
Bacterium flagged with complement
Receptor (CR3)
Beta Glucan Fragment
Captured Bacterium
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Two More Immune-Supporting Ingredients
▪Zinc▪Phagocytosis▪Generation of oxidative burst
▪Vitamin C▪Protects cell membrane from oxidative burst
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Wellmune Improves Mood State▪ S.M. Talbott and J.A. Talbott. Baker's Yeast Beta-Glucan
Supplement Reduces Upper Respiratory Symptoms and Improves Mood State in Stressed Women J Am Coll Nutr. August 2012 vol 31 no. 4 pp 295-300.
▪ S.M. Talbott and J.A. Talbott. Effect of BETA 1, 3/1, 6 GLUCAN on upper respiratory tract infection symptoms and mood state in marathon athletes Journal of Sports Science and Medicine (2009) 8, pp 509-515.
▪ Placebo controlled studies showing decreased confusion, fatigue, tension, anger and increased vigor after stress.
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nutraMetrix® Immune Benefits
▪Boosts the body’s natural immune response.▪Clinical trials show Wellmune® promotes a healthy immune system.
▪Promotes beneficial activity of macrophages.▪Promotes healthy energy levels and vitality.▪Improves mental clarity.