Supplementary Table 4Category Gene Class # Queried # In Class % In Class Ease Fisher Holm BP...

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Category Gene Class # Queried # In Class % In Class Ease Fisher Holm BP positive regulation of signal transduction 897 29 3.3 1.6E-04 6.8E-05 > 0.05 BP regulation of signal transduction 897 63.0 7.1 2.6E-04 1.6E-04 > 0.05 BP protein amino acid phosphorylation 897 51.0 5.7 2.7E-04 1.5E-04 > 0.05 BP enzyme linked receptor protein signaling pathway 897 31.0 3.5 3.8E-04 1.7E-04 > 0.05 BP positive regulation of cell communication 897 30.0 3.4 4.4E-04 2.0E-04 > 0.05 BP signal transduction 897 159.0 17.9 1.6E-03 1.3E-03 > 0.05 BP regulation of protein kinase cascade 897 23.0 2.6 2.0E-03 9.0E-04 > 0.05 BP positive regulation of protein kinase cascade 897 17.0 1.9 3.5E-03 1.4E-03 > 0.05 BP sphingoid metabolic process 897 8.0 0.9 3.7E-03 8.0E-04 > 0.05 BP regulation of cellular process 897 341.0 38.4 3.9E-03 3.5E-03 > 0.05 BP regulation of cell communication 897 66.0 7.4 4.0E-03 2.7E-03 > 0.05 BP phosphorus metabolic process 897 62.0 7.0 4.9E-03 3.4E-03 > 0.05 BP phosphate metabolic process 897 62.0 7.0 4.9E-03 3.4E-03 > 0.05 BP negative regulation of signal transduction 897 20.0 2.3 5.2E-03 2.4E-03 > 0.05 BP positive regulation of MAPKKK cascade 897 8.0 0.9 5.3E-03 1.2E-03 > 0.05 BP negative regulation of transcription 897 34.0 3.8 5.5E-03 3.1E-03 > 0.05 BP regulation of toll-like receptor signaling pathway 897 3.0 0.3 5.9E-03 9.1E-05 > 0.05 BP transmembrane receptor protein tyrosine kinase signaling pathway 897 20.0 2.3 6.0E-03 2.8E-03 > 0.05 BP positive regulation of cellular process 897 106.0 12.0 6.0E-03 4.6E-03 > 0.05 BP nucleoside monophosphate catabolic process 897 4.0 0.5 6.2E-03 4.3E-04 > 0.05 BP positive regulation of cell proliferation 897 31.0 3.5 7.0E-03 3.9E-03 > 0.05 BP post-translational protein modification 897 72.0 8.1 7.1E-03 5.0E-03 > 0.05 BP negative regulation of gene expression 897 36.0 4.1 7.3E-03 4.3E-03 > 0.05 BP phosphorylation 897 52.0 5.9 7.4E-03 4.9E-03 > 0.05 Supplementary Table 4. Enrichment of gene classes in vitro. Enrichment was analyzed using the Database for Annotation, Visualization, and Integrated Discovery (DAVID). Functional annotation charts were generated using each of the following GO terms: Biological Process (BP = GOTERM_BP_ALL), Molecular Function (MF = GOTERM_MF_ALL), and Protein Information Resource (PIR = SP_PIR_KEYWORDS). For each analysis, EASE threshold was set to 1 and Count threshold was set to 3. Significance was assessed using Fisher’s exact test with corrections for multiple comparisons (Holm-Bonferroni method). Results were considered significant at a level of p < 0.05. Significant results are highlighted in yellow.

Transcript of Supplementary Table 4Category Gene Class # Queried # In Class % In Class Ease Fisher Holm BP...

Category Gene Class # Queried # In Class % In Class Ease Fisher Holm

BP positive regulation of signal transduction 897 29 3.3 1.6E-04 6.8E-05 > 0.05

BP regulation of signal transduction 897 63.0 7.1 2.6E-04 1.6E-04 > 0.05

BP protein amino acid phosphorylation 897 51.0 5.7 2.7E-04 1.5E-04 > 0.05

BP enzyme linked receptor protein signaling pathway 897 31.0 3.5 3.8E-04 1.7E-04 > 0.05

BP positive regulation of cell communication 897 30.0 3.4 4.4E-04 2.0E-04 > 0.05

BP signal transduction 897 159.0 17.9 1.6E-03 1.3E-03 > 0.05

BP regulation of protein kinase cascade 897 23.0 2.6 2.0E-03 9.0E-04 > 0.05

BP positive regulation of protein kinase cascade 897 17.0 1.9 3.5E-03 1.4E-03 > 0.05

BP sphingoid metabolic process 897 8.0 0.9 3.7E-03 8.0E-04 > 0.05

BP regulation of cellular process 897 341.0 38.4 3.9E-03 3.5E-03 > 0.05

BP regulation of cell communication 897 66.0 7.4 4.0E-03 2.7E-03 > 0.05

BP phosphorus metabolic process 897 62.0 7.0 4.9E-03 3.4E-03 > 0.05

BP phosphate metabolic process 897 62.0 7.0 4.9E-03 3.4E-03 > 0.05

BP negative regulation of signal transduction 897 20.0 2.3 5.2E-03 2.4E-03 > 0.05

BP positive regulation of MAPKKK cascade 897 8.0 0.9 5.3E-03 1.2E-03 > 0.05

BP negative regulation of transcription 897 34.0 3.8 5.5E-03 3.1E-03 > 0.05

BP regulation of toll-like receptor signaling pathway 897 3.0 0.3 5.9E-03 9.1E-05 > 0.05

BP transmembrane receptor protein tyrosine kinase

signaling pathway

897 20.0 2.3 6.0E-03 2.8E-03 > 0.05

BP positive regulation of cellular process 897 106.0 12.0 6.0E-03 4.6E-03 > 0.05

BP nucleoside monophosphate catabolic process 897 4.0 0.5 6.2E-03 4.3E-04 > 0.05

BP positive regulation of cell proliferation 897 31.0 3.5 7.0E-03 3.9E-03 > 0.05

BP post-translational protein modification 897 72.0 8.1 7.1E-03 5.0E-03 > 0.05

BP negative regulation of gene expression 897 36.0 4.1 7.3E-03 4.3E-03 > 0.05

BP phosphorylation 897 52.0 5.9 7.4E-03 4.9E-03 > 0.05

Supplementary Table 4. Enrichment of gene classes in vitro. Enrichment was analyzed using the Database for Annotation, Visualization, and Integrated

Discovery (DAVID). Functional annotation charts were generated using each of the following GO terms: Biological Process (BP = GOTERM_BP_ALL),

Molecular Function (MF = GOTERM_MF_ALL), and Protein Information Resource (PIR = SP_PIR_KEYWORDS). For each analysis, EASE threshold was

set to 1 and Count threshold was set to 3. Significance was assessed using Fisher’s exact test with corrections for multiple comparisons (Holm-Bonferroni

method). Results were considered significant at a level of p < 0.05. Significant results are highlighted in yellow.

BP negative regulation of DNA binding 897 8.0 0.9 7.5E-03 1.9E-03 > 0.05

BP biopolymer modification 897 89.0 10.0 8.2E-03 6.1E-03 > 0.05

BP negative regulation of cell communication 897 21.0 2.4 8.6E-03 4.2E-03 > 0.05

BP negative regulation of biological process 897 103.0 11.6 8.9E-03 6.8E-03 > 0.05

BP protein modification process 897 85.0 9.6 9.0E-03 6.6E-03 > 0.05

BP protein kinase cascade 897 28.0 3.2 9.3E-03 5.2E-03 > 0.05

BP regulation of MAPKKK cascade 897 12.0 1.4 9.9E-03 3.6E-03 > 0.05

BP membrane lipid metabolic process 897 10.0 1.1 1.0E-02 3.4E-03 > 0.05

BP cAMP catabolic process 897 3.0 0.3 1.1E-02 3.5E-04 > 0.05

BP ceramide metabolic process 897 7.0 0.8 1.1E-02 2.5E-03 > 0.05

BP negative regulation of transcription,

DNA-dependent

897 27.0 3.0 1.1E-02 5.8E-03 > 0.05

BP regulation of biological process 897 349.0 39.3 1.2E-02 1.1E-02 > 0.05

BP negative regulation of RNA metabolic process 897 27.0 3.0 1.3E-02 7.2E-03 > 0.05

BP intracellular signaling cascade 897 74.00 8.3 1.3E-02 1.0E-02 > 0.05

BP regulation of cell cycle process 897 12.00 1.4 1.4E-02 5.2E-03 > 0.05

BP cell-cell signaling 897 40.00 4.5 1.4E-02 8.8E-03 > 0.05

BP negative regulation of macromolecule biosynthetic process 897 37.00 4.2 1.4E-02 8.9E-03 > 0.05

BP negative regulation of nucleobase, nucleoside, nucleotide and

nucleic acid metabolic process

897 35.00 3.9 1.5E-02 9.4E-03 > 0.05

BP peptidyl-tyrosine phosphorylation 897 7 0.8 1.6E-02 4.2E-03 > 0.05

BP negative regulation of binding 897 8 0.9 1.6E-02 4.7E-03 > 0.05

BP regionalization 897 17 1.9 1.6E-02 7.8E-03 > 0.05

BP transforming growth factor beta receptor signaling

pathway

897 8 0.9 1.8E-02 5.2E-03 > 0.05

BP negative regulation of nitrogen compound metabolic process 897 35 3.9 1.8E-02 1.1E-02 > 0.05

BP sphingolipid metabolic process 897 9 1.0 1.9E-02 6.4E-03 > 0.05

BP peptidyl-tyrosine modification 897 7 0.8 2.0E-02 5.4E-03 > 0.05

BP positive regulation of biological process 897 111 12.5 2.0E-02 1.6E-02 > 0.05

BP regulation of interleukin-6 production 897 6 0.7 2.2E-02 5.0E-03 > 0.05

BP response to peptide hormone stimulus 897 14 1.6 2.2E-02 9.8E-03 > 0.05

BP nervous system development 897 64 7.2 2.2E-02 1.6E-02 > 0.05

BP regulation of transcription, DNA-dependent 897 98 11.0 2.2E-02 1.8E-02 > 0.05

BP activation of MAPKK activity 897 5 0.6 2.4E-02 4.6E-03 > 0.05

BP neuropeptide signaling pathway 897 10 1.1 2.4E-02 9.0E-03 > 0.05

BP positive regulation of transferase activity 897 19 2.1 2.4E-02 1.2E-02 > 0.05

BP regulation of protein amino acid phosphorylation 897 15 1.7 2.4E-02 1.2E-02 > 0.05

BP negative regulation of developmental process 897 20 2.3 2.5E-02 1.3E-02 > 0.05

BP negative regulation of cellular process 897 92 10.4 2.5E-02 2.0E-02 > 0.05

BP regulation of protein modification process 897 22 2.5 2.6E-02 1.4E-02 > 0.05

BP biological regulation 897 362 40.8 2.6E-02 2.4E-02 > 0.05

BP cyclic nucleotide catabolic process 897 3 0.3 2.7E-02 1.6E-03 > 0.05

BP regulation of smooth muscle contraction 897 6 0.7 2.7E-02 6.6E-03 > 0.05

BP negative regulation of biosynthetic process 897 37 4.2 2.7E-02 1.8E-02 > 0.05

BP regulation of transcription 897 137 15.4 2.7E-02 2.3E-02 > 0.05

BP ceramide biosynthetic process 897 4 0.5 2.8E-02 3.7E-03 > 0.05

BP kidney development 897 10 1.1 2.9E-02 1.1E-02 > 0.05

BP negative regulation of molecular function 897 24 2.7 2.9E-02 1.7E-02 > 0.05

BP regulation of RNA metabolic process 897 99 11.2 2.9E-02 2.3E-02 > 0.05

BP regulation of developmental process 897 42 4.7 3.0E-02 2.1E-02 > 0.05

BP regulation of blood vessel size 897 7 0.8 3.1E-02 9.3E-03 > 0.05

BP regulation of tube size 897 7 0.8 3.1E-02 9.3E-03 > 0.05

BP multicellular organismal development 897 149 16.8 3.1E-02 2.7E-02 > 0.05

BP positive regulation of kinase activity 897 18 2.0 3.2E-02 1.7E-02 > 0.05

BP negative regulation of transcription from RNA polymerase II

promoter

897 20 2.3 3.2E-02 1.8E-02 > 0.05

BP negative regulation of cellular biosynthetic process 897 36 4.1 3.2E-02 2.1E-02 > 0.05

BP negative regulation of macromolecule metabolic process 897 45 5.1 3.2E-02 2.2E-02 > 0.05

BP sphingoid biosynthetic process 897 4 0.5 3.3E-02 4.8E-03 > 0.05

BP trophectodermal cell differentiation 897 4 0.5 3.3E-02 4.8E-03 > 0.05

BP positive regulation of organelle organization 897 9 1.0 3.3E-02 1.2E-02 > 0.05

BP pattern specification process 897 20 2.3 3.3E-02 1.8E-02 > 0.05

BP regulation of B cell proliferation 897 5 0.6 3.5E-02 7.6E-03 > 0.05

BP regulation of stress-activated protein kinase signaling pathway 897 8 0.9 3.5E-02 1.2E-02 > 0.05

BP MAPKKK cascade 897 15 1.7 3.8E-02 1.9E-02 > 0.05

BP regulation of response to stress 897 20 2.3 4.1E-02 2.3E-02 > 0.05

BP positive regulation of cell cycle 897 7 0.8 4.2E-02 1.4E-02 > 0.05

BP regulation of programmed cell death 897 48 5.4 4.4E-02 3.2E-02 > 0.05

BP regulation of gene expression 897 147 16.6 4.4E-02 3.8E-02 > 0.05

BP vascular process in circulatory system 897 7 0.8 4.5E-02 1.5E-02 > 0.05

BP positive regulation of defense response 897 8 0.9 4.5E-02 1.7E-02 > 0.05

BP positive regulation of protein kinase activity 897 17 1.9 4.5E-02 2.4E-02 > 0.05

BP regulation of macromolecule metabolic process 897 166 18.7 4.5E-02 3.9E-02 > 0.05

BP regulation of DNA binding 897 11 1.2 4.6E-02 2.1E-02 > 0.05

BP cell communication 897 47 5.3 4.7E-02 3.4E-02 > 0.05

BP regulation of cell death 897 48 5.4 4.8E-02 3.4E-02 > 0.05

BP immune system process 897 57 6.4 5.0E-02 3.8E-02 > 0.05

BP regulation of insulin receptor signaling pathway 897 4 0.5 5.1E-02 9.2E-03 > 0.05

BP intracellular receptor-mediated signaling pathway 897 8 0.9 5.1E-02 1.9E-02 > 0.05

BP anterior/posterior pattern formation 897 12 1.4 5.1E-02 2.4E-02 > 0.05

BP cellular lipid metabolic process 897 33 3.7 5.1E-02 3.4E-02 > 0.05

BP developmental process 897 160 18.0 5.1E-02 4.3E-02 > 0.05

BP negative regulation of metabolic process 897 46 5.2 5.2E-02 3.7E-02 > 0.05

BP regulation of metabolic process 897 182 20.5 5.2E-02 4.4E-02 > 0.05

BP regulation of macromolecule biosynthetic process 897 145 16.3 5.2E-02 4.5E-02 > 0.05

BP cellular process 897 493 55.6 5.2E-02 4.9E-02 > 0.05

BP B cell activation 897 8 0.9 5.4E-02 2.1E-02 > 0.05

BP positive regulation of innate immune response 897 6 0.7 5.5E-02 1.7E-02 > 0.05

BP regulation of nucleobase, nucleoside, nucleotide and nucleic acid

metabolic process

897 144 16.2 5.5E-02 4.7E-02 > 0.05

BP positive regulation of B cell proliferation 897 4 0.5 5.8E-02 1.1E-02 > 0.05

BP regulation of S phase 897 4 0.5 5.8E-02 1.1E-02 > 0.05

BP blastocyst formation 897 4 0.5 5.8E-02 1.1E-02 > 0.05

BP intermediate filament cytoskeleton organization 897 4 0.5 5.8E-02 1.1E-02 > 0.05

BP positive regulation of B cell activation 897 5 0.6 5.9E-02 1.5E-02 > 0.05

BP regulation of cell division 897 6 0.7 5.9E-02 1.8E-02 > 0.05

BP urogenital system development 897 10 1.1 6.0E-02 2.7E-02 > 0.05

BP female pregnancy 897 10 1.1 6.0E-02 2.7E-02 > 0.05

BP immune response 897 41 4.6 6.0E-02 4.2E-02 > 0.05

BP response to cytokine stimulus 897 8 0.9 6.4E-02 2.6E-02 > 0.05

BP negative regulation of cell differentiation 897 16 1.8 6.4E-02 3.5E-02 > 0.05

BP membrane lipid biosynthetic process 897 5 0.6 6.5E-02 1.7E-02 > 0.05

BP positive regulation of cellular component organization 897 14 1.6 6.5E-02 3.4E-02 > 0.05

BP positive regulation of stress-activated protein kinase signaling

pathway

897 4 0.5 6.6E-02 1.3E-02 > 0.05

BP organ development 897 92 10.4 6.6E-02 5.4E-02 > 0.05

BP negative regulation of multicellular organismal process 897 13 1.5 6.7E-02 3.4E-02 > 0.05

BP regulation of nitrogen compound metabolic process 897 144 16.2 6.8E-02 5.9E-02 > 0.05

BP response to hormone stimulus 897 24 2.7 6.9E-02 4.4E-02 > 0.05

BP response to organic substance 897 42 4.7 7.1E-02 5.3E-02 > 0.05

BP regulation of cellular metabolic process 897 173 19.5 7.1E-02 6.3E-02 > 0.05

BP cholesterol catabolic process 897 3 0.3 7.2E-02 8.6E-03 > 0.05

BP sterol catabolic process 897 3 0.3 7.2E-02 8.6E-03 > 0.05

BP regulation of cell cycle 897 22 2.5 7.2E-02 4.5E-02 > 0.05

BP multi-organism process 897 40 4.5 7.2E-02 5.1E-02 > 0.05

BP cellular metabolic process 897 318 35.9 7.2E-02 6.6E-02 > 0.05

BP intermediate filament-based process 897 4 0.5 7.4E-02 1.6E-02 > 0.05

BP regulation of hormone secretion 897 7 0.8 7.6E-02 2.8E-02 > 0.05

BP regulation of transferase activity 897 24 2.7 7.8E-02 5.0E-02 > 0.05

BP regulation of transcription from RNA polymerase II promoter 897 42 4.7 7.9E-02 5.7E-02 > 0.05

BP regulation of cell proliferation 897 45 5.1 7.9E-02 5.8E-02 > 0.05

BP negative regulation of response to stimulus 897 9 1.0 8.1E-02 3.6E-02 > 0.05

BP immune response-activating signal transduction 897 6 0.7 8.3E-02 2.9E-02 > 0.05

BP positive regulation of programmed cell death 897 27 3.0 8.3E-02 5.5E-02 > 0.05

BP response to exogenous dsRNA 897 3 0.3 8.5E-02 1.1E-02 > 0.05

BP regulation of peptidyl-tyrosine phosphorylation 897 7 0.8 8.5E-02 3.3E-02 > 0.05

BP regulation of cell differentiation 897 30 3.4 8.5E-02 5.8E-02 > 0.05

BP positive regulation of cell death 897 27 3.0 8.6E-02 5.8E-02 > 0.05

BP protein amino acid autophosphorylation 897 8 0.9 8.8E-02 3.7E-02 > 0.05

BP cell motion 897 29 3.3 8.8E-02 6.0E-02 > 0.05

BP negative regulation of cytokine production 897 5 0.6 9.0E-02 2.7E-02 > 0.05

BP regeneration 897 7 0.8 9.0E-02 3.5E-02 > 0.05

BP cellular macromolecule metabolic process 897 252 28.4 9.0E-02 8.2E-02 > 0.05

BP regulation of cellular response to stress 897 9 1.0 9.2E-02 4.3E-02 > 0.05

BP regulation of transcription factor activity 897 9 1.0 9.2E-02 4.3E-02 > 0.05

BP regulation of biosynthetic process 897 148 16.7 9.4E-02 8.5E-02 > 0.05

BP regulation of innate immune response 897 6 0.7 9.5E-02 3.4E-02 > 0.05

BP regulation of cell motion 897 14 1.6 9.6E-02 5.4E-02 > 0.05

BP primary metabolic process 897 329 37.1 9.6E-02 8.9E-02 > 0.05

BP positive regulation of cell division 897 5 0.6 9.7E-02 3.0E-02 > 0.05

BP negative regulation of cellular metabolic process 897 41 4.6 9.8E-02 7.3E-02 > 0.05

BP regulation of cellular biosynthetic process 897 147 16.6 9.9E-02 8.6E-02 > 0.05

BP response to dsRNA 897 4 0.5 1.0E-01 2.4E-02 > 0.05

BP negative regulation of immune response 897 4 0.5 1.0E-01 2.4E-02 > 0.05

BP phosphoinositide-mediated signaling 897 8 0.9 1.0E-01 4.5E-02 > 0.05

BP regulation of MAP kinase activity 897 11 1.2 1.0E-01 5.4E-02 > 0.05

BP brain development 897 19 2.1 1.0E-01 6.5E-02 > 0.05

BP response to endogenous stimulus 897 25 2.8 1.0E-01 6.9E-02 > 0.05

BP regulation of apoptosis 897 45 5.1 1.0E-01 7.9E-02 > 0.05

BP regulation of primary metabolic process 897 163 18.4 1.0E-01 8.8E-02 > 0.05

BP B cell proliferation 897 3 0.3 1.1E-01 1.9E-02 > 0.05

BP vasodilation 897 4 0.5 1.1E-01 2.8E-02 > 0.05

BP response to antibiotic 897 4 0.5 1.1E-01 2.8E-02 > 0.05

BP activation of JUN kinase activity 897 4 0.5 1.1E-01 2.8E-02 > 0.05

BP positive regulation of NF-kappaB transcription factor activity 897 5 0.6 1.1E-01 3.6E-02 > 0.05

BP regulation of mitosis 897 6 0.7 1.1E-01 3.9E-02 > 0.05

BP regulation of nuclear division 897 6 0.7 1.1E-01 3.9E-02 > 0.05

BP immune response-regulating signal transduction 897 6 0.7 1.1E-01 3.9E-02 > 0.05

BP regulation of I-kappaB kinase/NF-kappaB cascade 897 9 1.0 1.1E-01 5.2E-02 > 0.05

BP regulation of defense response 897 11 1.2 1.1E-01 5.8E-02 > 0.05

BP regulation of cellular component size 897 18 2.0 1.1E-01 6.5E-02 > 0.05

BP regulation of response to stimulus 897 28 3.2 1.1E-01 7.3E-02 > 0.05

BP regulation of phosphorylation 897 28 3.2 1.1E-01 7.3E-02 > 0.05

BP transcription 897 107 12.1 1.1E-01 9.0E-02 > 0.05

BP macromolecule metabolic process 897 273 30.8 1.1E-01 1.0E-01 > 0.05

BP steroid hormone receptor signaling pathway 897 6 0.7 1.2E-01 4.6E-02 > 0.05

BP tube development 897 15 1.7 1.2E-01 7.3E-02 > 0.05

BP cell division 897 19 2.1 1.2E-01 7.6E-02 > 0.05

BP regulation of localization 897 35 3.9 1.2E-01 8.6E-02 > 0.05

BP regulation of multicellular organismal process 897 51 5.7 1.2E-01 9.1E-02 > 0.05

BP system development 897 117 13.2 1.2E-01 1.1E-01 > 0.05

BP head development 897 3 0.3 1.3E-01 2.3E-02 > 0.05

BP regulation of interleukin-6 biosynthetic process 897 3 0.3 1.3E-01 2.3E-02 > 0.05

BP regulation of Rho GTPase activity 897 4 0.5 1.3E-01 3.5E-02 > 0.05

BP epidermal growth factor receptor signaling pathway 897 4 0.5 1.3E-01 3.5E-02 > 0.05

BP positive regulation of transcription factor activity 897 6 0.7 1.3E-01 5.2E-02 > 0.05

BP regulation of kinase activity 897 22 2.5 1.3E-01 8.6E-02 > 0.05

BP cell proliferation 897 26 2.9 1.3E-01 8.9E-02 > 0.05

BP regulation of molecular function 897 52 5.9 1.3E-01 1.1E-01 > 0.05

BP positive regulation of tumor necrosis factor production 897 3 0.3 1.4E-01 2.8E-02 > 0.05

BP biogenic amine catabolic process 897 3 0.3 1.4E-01 2.8E-02 > 0.05

BP negative regulation of transcription factor activity 897 5 0.6 1.4E-01 5.1E-02 > 0.05

BP regulation of cell size 897 14 1.6 1.4E-01 8.3E-02 > 0.05

BP neurogenesis 897 34 3.8 1.4E-01 1.0E-01 > 0.05

BP metabolic process 897 359 40.5 1.4E-01 1.3E-01 > 0.05

BP regulation of organ growth 897 4 0.5 1.5E-01 4.4E-02 > 0.05

BP embryo implantation 897 4 0.5 1.5E-01 4.4E-02 > 0.05

BP negative regulation of Wnt receptor signaling pathway 897 4 0.5 1.5E-01 4.4E-02 > 0.05

BP cytokine production 897 5 0.6 1.5E-01 5.5E-02 > 0.05

BP positive regulation of growth 897 7 0.8 1.5E-01 6.9E-02 > 0.05

BP positive regulation of phosphorylation 897 8 0.9 1.5E-01 7.1E-02 > 0.05

BP positive regulation of I-kappaB kinase/NF-kappaB cascade 897 8 0.9 1.5E-01 7.1E-02 > 0.05

BP meiosis 897 8 0.9 1.5E-01 7.4E-02 > 0.05

BP M phase of meiotic cell cycle 897 8 0.9 1.5E-01 7.4E-02 > 0.05

BP regulation of binding 897 11 1.2 1.5E-01 8.5E-02 > 0.05

BP positive regulation of cell differentiation 897 15 1.7 1.5E-01 9.5E-02 > 0.05

BP regulation of protein kinase activity 897 21 2.4 1.5E-01 1.0E-01 > 0.05

BP cell motility 897 19 2.1 1.5E-01 1.0E-01 > 0.05

BP localization of cell 897 19 2.1 1.5E-01 1.0E-01 > 0.05

BP positive regulation of molecular function 897 33 3.7 1.5E-01 1.1E-01 > 0.05

BP central nervous system development 897 25 2.8 1.5E-01 1.1E-01 > 0.05

BP regulation of phosphorus metabolic process 897 28 3.2 1.5E-01 1.1E-01 > 0.05

BP regulation of phosphate metabolic process 897 28 3.2 1.5E-01 1.1E-01 > 0.05

BP DNA metabolic process 897 29 3.3 1.5E-01 1.1E-01 > 0.05

BP regulation of cytokine-mediated signaling pathway 897 3 0.3 1.6E-01 3.3E-02 > 0.05

BP negative regulation of NF-kappaB transcription factor activity 897 3 0.3 1.6E-01 3.3E-02 > 0.05

BP negative regulation of immune effector process 897 3 0.3 1.6E-01 3.3E-02 > 0.05

BP regulation of S phase of mitotic cell cycle 897 3 0.3 1.6E-01 3.3E-02 > 0.05

BP regulation of tumor necrosis factor production 897 4 0.5 1.6E-01 4.9E-02 > 0.05

BP sphingolipid biosynthetic process 897 4 0.5 1.6E-01 4.9E-02 > 0.05

BP regulation of tyrosine phosphorylation of STAT protein 897 4 0.5 1.6E-01 4.9E-02 > 0.05

BP membrane docking 897 4 0.5 1.6E-01 4.9E-02 > 0.05

BP glycolipid metabolic process 897 4 0.5 1.6E-01 4.9E-02 > 0.05

BP regulation of developmental growth 897 5 0.6 1.6E-01 5.9E-02 > 0.05

BP positive regulation of peptidyl-tyrosine phosphorylation 897 5 0.6 1.6E-01 5.9E-02 > 0.05

BP activation of MAPK activity 897 7 0.8 1.6E-01 7.6E-02 > 0.05

BP positive regulation of phosphate metabolic process 897 8 0.9 1.6E-01 8.2E-02 > 0.05

BP meiotic cell cycle 897 8 0.9 1.6E-01 8.2E-02 > 0.05

BP response to insulin stimulus 897 8 0.9 1.6E-01 8.2E-02 > 0.05

BP positive regulation of phosphorus metabolic process 897 8 0.9 1.6E-01 8.2E-02 > 0.05

BP organic acid biosynthetic process 897 11 1.2 1.6E-01 9.1E-02 > 0.05

BP carboxylic acid biosynthetic process 897 11 1.2 1.6E-01 9.1E-02 > 0.05

BP positive regulation of apoptosis 897 25 2.8 1.6E-01 1.1E-01 > 0.05

BP positive regulation of JUN kinase activity 897 4 0.5 1.7E-01 5.4E-02 > 0.05

BP negative regulation of hydrolase activity 897 5 0.6 1.7E-01 6.4E-02 > 0.05

BP regulation of JNK cascade 897 6 0.7 1.7E-01 7.2E-02 > 0.05

BP regulation of cell growth 897 13 1.5 1.7E-01 1.0E-01 > 0.05

BP cell cycle phase 897 24 2.7 1.7E-01 1.2E-01 > 0.05

BP regulation of cellular protein metabolic process 897 27 3.0 1.7E-01 1.3E-01 > 0.05

BP pattern recognition receptor signaling pathway 897 3 0.3 1.8E-01 3.9E-02 > 0.05

BP response to interleukin-1 897 3 0.3 1.8E-01 3.9E-02 > 0.05

BP regulation of interleukin-12 production 897 3 0.3 1.8E-01 3.9E-02 > 0.05

BP regulation of tyrosine phosphorylation of Stat3 protein 897 3 0.3 1.8E-01 3.9E-02 > 0.05

BP protein ubiquitination during ubiquitin-dependent

protein catabolic process

897 3 0.3 1.8E-01 3.9E-02 > 0.05

BP negative regulation of neuron differentiation 897 4 0.5 1.8E-01 5.9E-02 > 0.05

BP purine nucleotide catabolic process 897 4 0.5 1.8E-01 5.9E-02 > 0.05

BP positive regulation of MAP kinase activity 897 8 0.9 1.8E-01 8.9E-02 > 0.05

BP transmembrane receptor protein serine/threonine

kinase signaling pathway

897 8 0.9 1.8E-01 9.3E-02 > 0.05

BP interphase of mitotic cell cycle 897 8 0.9 1.8E-01 9.3E-02 > 0.05

BP positive regulation of response to stimulus 897 15 1.7 1.8E-01 1.1E-01 > 0.05

BP regulation of organelle organization 897 14 1.6 1.8E-01 1.1E-01 > 0.05

BP negative regulation of catalytic activity 897 17 1.9 1.8E-01 1.2E-01 > 0.05

BP regulation of catalytic activity 897 45 5.1 1.8E-01 1.4E-01 > 0.05

BP detection of biotic stimulus 897 3 0.3 1.9E-01 4.5E-02 > 0.05

BP negative regulation of caspase activity 897 3 0.3 1.9E-01 4.5E-02 > 0.05

BP cellular response to insulin stimulus 897 6 0.7 1.9E-01 8.5E-02 > 0.05

BP peptidyl-amino acid modification 897 11 1.2 1.9E-01 1.1E-01 > 0.05

BP lymphocyte activation 897 13 1.5 1.9E-01 1.2E-01 > 0.05

BP regulation of cytokine production 897 12 1.4 1.9E-01 1.2E-01 > 0.05

BP positive regulation of catalytic activity 897 29 3.3 1.9E-01 1.4E-01 > 0.05

BP anatomical structure development 897 123 13.9 1.9E-01 1.7E-01 > 0.05

BP nucleotide catabolic process 897 5 0.6 2.0E-01 7.9E-02 > 0.05

BP regulation of B cell activation 897 5 0.6 2.0E-01 7.9E-02 > 0.05

BP interphase 897 8 0.9 2.0E-01 1.1E-01 > 0.05

BP leukocyte activation 897 15 1.7 2.0E-01 1.3E-01 > 0.05

BP regulation of growth 897 20 2.3 2.0E-01 1.4E-01 > 0.05

BP monocarboxylic acid metabolic process 897 18 2.0 2.0E-01 1.4E-01 > 0.05

BP positive regulation of macromolecule metabolic process 897 45 5.1 2.0E-01 1.6E-01 > 0.05

BP positive regulation of metabolic process 897 48 5.4 2.0E-01 1.6E-01 > 0.05

BP cellular protein metabolic process 897 115 13.0 2.0E-01 1.8E-01 > 0.05

BP prostanoid metabolic process 897 3 0.3 2.1E-01 5.2E-02 > 0.05

BP innate immune response-activating signal transduction 897 3 0.3 2.1E-01 5.2E-02 > 0.05

BP cellular amino acid derivative catabolic process 897 3 0.3 2.1E-01 5.2E-02 > 0.05

BP prostaglandin metabolic process 897 3 0.3 2.1E-01 5.2E-02 > 0.05

BP glutamine metabolic process 897 3 0.3 2.1E-01 5.2E-02 > 0.05

BP activation of innate immune response 897 3 0.3 2.1E-01 5.2E-02 > 0.05

BP platelet-derived growth factor receptor signaling pathway 897 3 0.3 2.1E-01 5.2E-02 > 0.05

BP retina development in camera-type eye 897 4 0.5 2.1E-01 7.1E-02 > 0.05

BP neuromuscular process controlling balance 897 4 0.5 2.1E-01 7.1E-02 > 0.05

BP activation of phospholipase C activity by G-protein coupled

receptor protein signaling pathway coupled to IP3 second

messenger

897 5 0.6 2.1E-01 8.4E-02 > 0.05

BP membrane fusion 897 5 0.6 2.1E-01 8.9E-02 > 0.05

BP positive regulation of DNA binding 897 6 0.7 2.1E-01 9.5E-02 > 0.05

BP positive regulation of protein amino acid phosphorylation 897 7 0.8 2.1E-01 1.1E-01 > 0.05

BP cellular amino acid derivative metabolic process 897 11 1.2 2.1E-01 1.3E-01 > 0.05

BP regulation of JAK-STAT cascade 897 4 0.5 2.2E-01 7.7E-02 > 0.05

BP androgen receptor signaling pathway 897 4 0.5 2.2E-01 7.7E-02 > 0.05

BP regulation of protein complex assembly 897 7 0.8 2.2E-01 1.1E-01 > 0.05

BP regulation of muscle contraction 897 6 0.7 2.2E-01 1.1E-01 > 0.05

BP biopolymer glycosylation 897 9 1.0 2.2E-01 1.2E-01 > 0.05

BP glycosylation 897 9 1.0 2.2E-01 1.2E-01 > 0.05

BP protein amino acid glycosylation 897 9 1.0 2.2E-01 1.2E-01 > 0.05

BP positive regulation of protein modification process 897 12 1.4 2.2E-01 1.4E-01 > 0.05

BP programmed cell death 897 33 3.7 2.2E-01 1.6E-01 > 0.05

BP cell adhesion 897 37 4.2 2.2E-01 1.7E-01 > 0.05

BP biological adhesion 897 37 4.2 2.2E-01 1.8E-01 > 0.05

BP DNA integration 897 3 0.3 2.3E-01 5.9E-02 > 0.05

BP response to axon injury 897 3 0.3 2.3E-01 5.9E-02 > 0.05

BP regulation of JUN kinase activity 897 4 0.5 2.3E-01 8.4E-02 > 0.05

BP insulin receptor signaling pathway 897 4 0.5 2.3E-01 8.4E-02 > 0.05

BP learning or memory 897 8 0.9 2.3E-01 1.3E-01 > 0.05

BP positive regulation of cell activation 897 8 0.9 2.3E-01 1.3E-01 > 0.05

BP locomotion 897 24 2.7 2.3E-01 1.7E-01 > 0.05

BP negative regulation of peptidase activity 897 3 0.3 2.4E-01 6.6E-02 > 0.05

BP cAMP metabolic process 897 3 0.3 2.4E-01 6.6E-02 > 0.05

BP steroid catabolic process 897 3 0.3 2.4E-01 6.6E-02 > 0.05

BP cyclic nucleotide metabolic process 897 4 0.5 2.4E-01 9.0E-02 > 0.05

BP G1/S transition of mitotic cell cycle 897 5 0.6 2.4E-01 1.1E-01 > 0.05

BP eye development 897 9 1.0 2.4E-01 1.4E-01 > 0.05

BP phospholipid metabolic process 897 12 1.4 2.4E-01 1.5E-01 > 0.05

BP chordate embryonic development 897 19 2.1 2.4E-01 1.7E-01 > 0.05

BP apoptosis 897 32 3.6 2.4E-01 1.9E-01 > 0.05

BP protein metabolic process 897 135 15.2 2.4E-01 2.1E-01 > 0.05

BP cellular response to hormone stimulus 897 9 1.0 2.5E-01 1.5E-01 > 0.05

BP positive regulation of cellular protein metabolic process 897 14 1.6 2.5E-01 1.7E-01 > 0.05

BP embryonic development ending in birth or egg hatching 897 19 2.1 2.5E-01 1.8E-01 > 0.05

BP regulation of cellular component organization 897 25 2.8 2.5E-01 1.9E-01 > 0.05

BP positive regulation of cellular metabolic process 897 45 5.1 2.5E-01 2.0E-01 > 0.05

BP activation of pro-apoptotic gene products 897 3 0.3 2.6E-01 7.4E-02 > 0.05

BP immune response-activating cell surface receptor signaling

pathway

897 4 0.5 2.6E-01 9.7E-02 > 0.05

BP JAK-STAT cascade 897 4 0.5 2.6E-01 9.7E-02 > 0.05

BP regulation of transforming growth factor beta receptor signaling

pathway

897 4 0.5 2.6E-01 9.7E-02 > 0.05

BP nucleobase, nucleoside and nucleotide catabolic process 897 5 0.6 2.6E-01 1.2E-01 > 0.05

BP nucleobase, nucleoside, nucleotide and nucleic acid catabolic

process

897 5 0.6 2.6E-01 1.2E-01 > 0.05

BP regulation of inflammatory response 897 6 0.7 2.6E-01 1.3E-01 > 0.05

BP negative regulation of transferase activity 897 7 0.8 2.6E-01 1.4E-01 > 0.05

BP heart development 897 13 1.5 2.6E-01 1.7E-01 > 0.05

BP cell migration 897 16 1.8 2.6E-01 1.8E-01 > 0.05

BP cell-cell adhesion 897 16 1.8 2.6E-01 1.8E-01 > 0.05

BP regulation of protein metabolic process 897 29 3.3 2.6E-01 2.0E-01 > 0.05

BP regulation of insulin secretion 897 4 0.5 2.7E-01 1.0E-01 > 0.05

BP response to lipopolysaccharide 897 6 0.7 2.7E-01 1.3E-01 > 0.05

BP embryonic skeletal system development 897 6 0.7 2.7E-01 1.3E-01 > 0.05

BP heterocycle catabolic process 897 6 0.7 2.7E-01 1.3E-01 > 0.05

BP pigmentation 897 5 0.6 2.7E-01 1.3E-01 > 0.05

BP positive regulation of binding 897 6 0.7 2.7E-01 1.4E-01 > 0.05

BP positive regulation of developmental process 897 16 1.8 2.7E-01 1.9E-01 > 0.05

BP positive regulation of biosynthetic process 897 36 4.1 2.7E-01 2.1E-01 > 0.05

BP macromolecule biosynthetic process 897 135 15.2 2.7E-01 2.4E-01 > 0.05

BP cellular macromolecule biosynthetic process 897 134 15.1 2.7E-01 2.4E-01 > 0.05

BP positive regulation of tyrosine phosphorylation of STAT protein 897 3 0.3 2.8E-01 8.3E-02 > 0.05

BP response to xenobiotic stimulus 897 3 0.3 2.8E-01 8.3E-02 > 0.05

BP regulation of production of molecular mediator of immune

response

897 4 0.5 2.8E-01 1.1E-01 > 0.05

BP cytokinesis 897 4 0.5 2.8E-01 1.1E-01 > 0.05

BP dorsal/ventral pattern formation 897 5 0.6 2.8E-01 1.3E-01 > 0.05

BP hindbrain development 897 5 0.6 2.8E-01 1.3E-01 > 0.05

BP learning 897 5 0.6 2.8E-01 1.3E-01 > 0.05

BP positive regulation of cell motion 897 7 0.8 2.8E-01 1.5E-01 > 0.05

BP regulation of protein localization 897 9 1.0 2.8E-01 1.7E-01 > 0.05

BP fatty acid metabolic process 897 12 1.4 2.8E-01 1.8E-01 > 0.05

BP glycoprotein biosynthetic process 897 10 1.1 2.8E-01 1.8E-01 > 0.05

BP positive regulation of immune system process 897 14 1.6 2.8E-01 1.9E-01 > 0.05

BP regulation of B cell mediated immunity 897 3 0.3 2.9E-01 9.1E-02 > 0.05

BP regulation of immunoglobulin mediated immune response 897 3 0.3 2.9E-01 9.1E-02 > 0.05

BP response to acid 897 3 0.3 2.9E-01 9.1E-02 > 0.05

BP immune response-regulating cell surface receptor signaling

pathway

897 4 0.5 2.9E-01 1.2E-01 > 0.05

BP lymphocyte proliferation 897 4 0.5 2.9E-01 1.2E-01 > 0.05

BP carbohydrate transport 897 5 0.6 2.9E-01 1.4E-01 > 0.05

BP organophosphate metabolic process 897 12 1.4 2.9E-01 1.9E-01 > 0.05

BP lipid biosynthetic process 897 18 2.0 2.9E-01 2.1E-01 > 0.05

BP glycoprotein metabolic process 897 12 1.4 3.0E-01 2.0E-01 > 0.05

BP positive regulation of protein metabolic process 897 14 1.6 3.0E-01 2.1E-01 > 0.05

BP lipid metabolic process 897 41 4.6 3.0E-01 2.5E-01 > 0.05

BP positive regulation of nuclear division 897 3 0.3 3.1E-01 1.0E-01 > 0.05

BP positive regulation of mitosis 897 3 0.3 3.1E-01 1.0E-01 > 0.05

BP negative regulation of cell cycle process 897 3 0.3 3.1E-01 1.0E-01 > 0.05

BP regulation of foam cell differentiation 897 3 0.3 3.1E-01 1.0E-01 > 0.05

BP blastocyst development 897 4 0.5 3.1E-01 1.3E-01 > 0.05

BP regulation of lymphocyte differentiation 897 5 0.6 3.1E-01 1.5E-01 > 0.05

BP respiratory tube development 897 7 0.8 3.1E-01 1.8E-01 > 0.05

BP cell activation 897 16 1.8 3.1E-01 2.3E-01 > 0.05

BP positive regulation of transcription from RNA polymerase II

promoter

897 20 2.3 3.1E-01 2.3E-01 > 0.05

BP generation of neurons 897 29 3.3 3.1E-01 2.4E-01 > 0.05

BP positive regulation of nitrogen compound metabolic process 897 33 3.7 3.1E-01 2.5E-01 > 0.05

BP leukocyte proliferation 897 4 0.5 3.2E-01 1.4E-01 > 0.05

BP metanephros development 897 4 0.5 3.2E-01 1.4E-01 > 0.05

BP mononuclear cell proliferation 897 4 0.5 3.2E-01 1.4E-01 > 0.05

BP nucleoside metabolic process 897 5 0.6 3.2E-01 1.6E-01 > 0.05

BP negative regulation of immune system process 897 6 0.7 3.2E-01 1.7E-01 > 0.05

BP lymphocyte differentiation 897 7 0.8 3.2E-01 1.8E-01 > 0.05

BP positive regulation of transcription, DNA-dependent 897 25 2.8 3.2E-01 2.4E-01 > 0.05

BP cellular macromolecule localization 897 22 2.5 3.2E-01 2.4E-01 > 0.05

BP positive regulation of nucleobase, nucleoside, nucleotide and

nucleic acid metabolic process

897 32 3.6 3.2E-01 2.5E-01 > 0.05

BP organ morphogenesis 897 29 3.3 3.2E-01 2.6E-01 > 0.05

BP positive regulation of fibroblast proliferation 897 3 0.3 3.3E-01 1.1E-01 > 0.05

BP positive regulation of JAK-STAT cascade 897 3 0.3 3.3E-01 1.1E-01 > 0.05

BP negative regulation of hormone secretion 897 3 0.3 3.3E-01 1.1E-01 > 0.05

BP glycosphingolipid metabolic process 897 3 0.3 3.3E-01 1.1E-01 > 0.05

BP pigmentation during development 897 3 0.3 3.3E-01 1.1E-01 > 0.05

BP stem cell development 897 3 0.3 3.3E-01 1.1E-01 > 0.05

BP vesicle docking 897 3 0.3 3.3E-01 1.1E-01 > 0.05

BP positive regulation of cytoskeleton organization 897 4 0.5 3.3E-01 1.4E-01 > 0.05

BP positive regulation of immune response 897 9 1.0 3.3E-01 2.1E-01 > 0.05

BP regulation of neurogenesis 897 10 1.1 3.3E-01 2.2E-01 > 0.05

BP positive regulation of RNA metabolic process 897 25 2.8 3.3E-01 2.6E-01 > 0.05

BP cellular biosynthetic process 897 161 18.2 3.3E-01 3.1E-01 > 0.05

BP body fluid secretion 897 3 0.3 3.4E-01 1.2E-01 > 0.05

BP circadian rhythm 897 4 0.5 3.4E-01 1.5E-01 > 0.05

BP regulation of peptide secretion 897 4 0.5 3.4E-01 1.5E-01 > 0.05

BP regulation of Wnt receptor signaling pathway 897 4 0.5 3.4E-01 1.5E-01 > 0.05

BP activation of phospholipase C activity 897 5 0.6 3.4E-01 1.7E-01 > 0.05

BP development of primary male sexual characteristics 897 5 0.6 3.4E-01 1.7E-01 > 0.05

BP positive regulation of phospholipase C activity 897 5 0.6 3.4E-01 1.7E-01 > 0.05

BP T cell differentiation 897 5 0.6 3.4E-01 1.7E-01 > 0.05

BP telencephalon development 897 5 0.6 3.4E-01 1.7E-01 > 0.05

BP response to molecule of bacterial origin 897 6 0.7 3.4E-01 1.9E-01 > 0.05

BP positive regulation of leukocyte activation 897 7 0.8 3.4E-01 2.0E-01 > 0.05

BP sensory organ development 897 13 1.5 3.4E-01 2.4E-01 > 0.05

BP icosanoid metabolic process 897 4 0.5 3.5E-01 1.6E-01 > 0.05

BP nucleoside monophosphate metabolic process 897 5 0.6 3.5E-01 1.8E-01 > 0.05

BP negative regulation of protein kinase activity 897 6 0.7 3.5E-01 2.0E-01 > 0.05

BP regulation of lipase activity 897 6 0.7 3.5E-01 2.0E-01 > 0.05

BP development of primary sexual characteristics 897 8 0.9 3.5E-01 2.1E-01 > 0.05

BP camera-type eye development 897 7 0.8 3.5E-01 2.1E-01 > 0.05

BP angiogenesis 897 9 1.0 3.5E-01 2.2E-01 > 0.05

BP rhythmic process 897 8 0.9 3.5E-01 2.2E-01 > 0.05

BP regulation of cell migration 897 10 1.1 3.5E-01 2.3E-01 > 0.05

BP blood vessel morphogenesis 897 12 1.4 3.5E-01 2.4E-01 > 0.05

BP regulation of hydrolase activity 897 18 2.0 3.5E-01 2.6E-01 > 0.05

BP negative regulation of programmed cell death 897 19 2.1 3.5E-01 2.7E-01 > 0.05

BP response to chemical stimulus 897 62 7.0 3.5E-01 3.0E-01 > 0.05

BP antigen processing and presentation of peptide antigen 897 3 0.3 3.6E-01 1.3E-01 > 0.05

BP leukocyte adhesion 897 3 0.3 3.6E-01 1.3E-01 > 0.05

BP cellular aldehyde metabolic process 897 3 0.3 3.6E-01 1.3E-01 > 0.05

BP nitrogen compound catabolic process 897 5 0.6 3.6E-01 1.8E-01 > 0.05

BP positive regulation of protein transport 897 5 0.6 3.6E-01 1.8E-01 > 0.05

BP respiratory system development 897 7 0.8 3.6E-01 2.1E-01 > 0.05

BP regulation of nervous system development 897 11 1.2 3.6E-01 2.5E-01 > 0.05

BP regulation of locomotion 897 11 1.2 3.6E-01 2.5E-01 > 0.05

BP membrane organization 897 20 2.3 3.6E-01 2.7E-01 > 0.05

BP negative regulation of cell death 897 19 2.1 3.6E-01 2.7E-01 > 0.05

BP carboxylic acid metabolic process 897 28 3.2 3.6E-01 3.0E-01 > 0.05

BP oxoacid metabolic process 897 28 3.2 3.6E-01 3.0E-01 > 0.05

BP cell surface receptor linked signal transduction 897 88 9.9 3.6E-01 3.2E-01 > 0.05

BP sex differentiation 897 9 1.0 3.7E-01 2.4E-01 > 0.05

BP embryonic organ development 897 10 1.1 3.7E-01 2.5E-01 > 0.05

BP second-messenger-mediated signaling 897 13 1.5 3.7E-01 2.6E-01 > 0.05

BP regulation of immune system process 897 20 2.3 3.7E-01 3.0E-01 > 0.05

BP fibroblast growth factor receptor signaling pathway 897 3 0.3 3.8E-01 1.4E-01 > 0.05

BP glucose transport 897 3 0.3 3.8E-01 1.4E-01 > 0.05

BP positive regulation of phospholipase activity 897 5 0.6 3.8E-01 2.0E-01 > 0.05

BP positive regulation of cytokine production 897 6 0.7 3.8E-01 2.2E-01 > 0.05

BP negative regulation of kinase activity 897 6 0.7 3.8E-01 2.2E-01 > 0.05

BP leukocyte differentiation 897 8 0.9 3.8E-01 2.4E-01 > 0.05

BP regulation of mitotic cell cycle 897 9 1.0 3.8E-01 2.5E-01 > 0.05

BP forebrain development 897 9 1.0 3.8E-01 2.5E-01 > 0.05

BP positive regulation of cellular biosynthetic process 897 34 3.8 3.8E-01 3.1E-01 > 0.05

BP biosynthetic process 897 164 18.5 3.8E-01 3.5E-01 > 0.05

BP negative regulation of myeloid cell differentiation 897 3 0.3 3.9E-01 1.5E-01 > 0.05

BP positive regulation of inflammatory response 897 3 0.3 3.9E-01 1.5E-01 > 0.05

BP axis specification 897 3 0.3 3.9E-01 1.5E-01 > 0.05

BP hexose transport 897 3 0.3 3.9E-01 1.5E-01 > 0.05

BP regulation of chromosome organization 897 3 0.3 3.9E-01 1.5E-01 > 0.05

BP regulation of myeloid cell differentiation 897 5 0.6 3.9E-01 2.1E-01 > 0.05

BP integrin-mediated signaling pathway 897 5 0.6 3.9E-01 2.1E-01 > 0.05

BP cytokine-mediated signaling pathway 897 5 0.6 3.9E-01 2.1E-01 > 0.05

BP gonad development 897 7 0.8 3.9E-01 2.4E-01 > 0.05

BP regulation of neuron differentiation 897 8 0.9 3.9E-01 2.5E-01 > 0.05

BP protein amino acid dephosphorylation 897 8 0.9 3.9E-01 2.5E-01 > 0.05

BP dephosphorylation 897 9 1.0 3.9E-01 2.6E-01 > 0.05

BP hemopoietic or lymphoid organ development 897 14 1.6 3.9E-01 2.9E-01 > 0.05

BP cellular protein localization 897 21 2.4 3.9E-01 3.0E-01 > 0.05

BP organic acid metabolic process 897 28 3.2 3.9E-01 3.2E-01 > 0.05

BP nucleobase, nucleoside, nucleotide and nucleic

acid metabolic process

897 158 17.8 3.9E-01 3.6E-01 > 0.05

BP regulation of T cell differentiation 897 4 0.5 4.0E-01 2.0E-01 > 0.05

BP unsaturated fatty acid metabolic process 897 4 0.5 4.0E-01 2.0E-01 > 0.05

BP regulation of protein complex disassembly 897 4 0.5 4.0E-01 2.0E-01 > 0.05

BP regulation of phospholipase activity 897 5 0.6 4.0E-01 2.2E-01 > 0.05

BP negative regulation of cell growth 897 6 0.7 4.0E-01 2.3E-01 > 0.05

BP cholesterol metabolic process 897 6 0.7 4.0E-01 2.3E-01 > 0.05

BP microtubule-based movement 897 7 0.8 4.0E-01 2.5E-01 > 0.05

BP regulation of anatomical structure morphogenesis 897 12 1.4 4.0E-01 2.8E-01 > 0.05

BP reproductive developmental process 897 14 1.6 4.0E-01 2.9E-01 > 0.05

BP cell death 897 35 3.9 4.0E-01 3.4E-01 > 0.05

BP monosaccharide transport 897 3 0.3 4.1E-01 1.6E-01 > 0.05

BP icosanoid biosynthetic process 897 3 0.3 4.1E-01 1.6E-01 > 0.05

BP positive regulation of smooth muscle cell proliferation 897 3 0.3 4.1E-01 1.6E-01 > 0.05

BP activation of protein kinase activity 897 7 0.8 4.1E-01 2.5E-01 > 0.05

BP regulation of homeostatic process 897 7 0.8 4.1E-01 2.5E-01 > 0.05

BP cellular ketone metabolic process 897 28 3.2 4.1E-01 3.3E-01 > 0.05

BP positive regulation of macromolecule biosynthetic process 897 32 3.6 4.1E-01 3.4E-01 > 0.05

BP multicellular organismal process 897 196 22.1 4.1E-01 3.9E-01 > 0.05

BP male gonad development 897 4 0.5 4.2E-01 2.1E-01 > 0.05

BP glutamine family amino acid metabolic process 897 4 0.5 4.2E-01 2.1E-01 > 0.05

BP post-embryonic development 897 5 0.6 4.2E-01 2.3E-01 > 0.05

BP male sex differentiation 897 5 0.6 4.2E-01 2.3E-01 > 0.05

BP activation of immune response 897 6 0.7 4.2E-01 2.5E-01 > 0.05

BP sulfur metabolic process 897 7 0.8 4.2E-01 2.6E-01 > 0.05

BP nuclear transport 897 9 1.0 4.2E-01 2.8E-01 > 0.05

BP M phase 897 17 1.9 4.2E-01 3.2E-01 > 0.05

BP embryonic development 897 28 3.2 4.2E-01 3.4E-01 > 0.05

BP death 897 35 3.9 4.2E-01 3.7E-01 > 0.05

BP negative regulation of protein amino acid phosphorylation 897 3 0.3 4.3E-01 1.7E-01 > 0.05

BP detection of chemical stimulus 897 3 0.3 4.3E-01 1.7E-01 > 0.05

BP tissue regeneration 897 3 0.3 4.3E-01 1.7E-01 > 0.05

BP stem cell differentiation 897 3 0.3 4.3E-01 1.7E-01 > 0.05

BP regulation of proteolysis 897 4 0.5 4.3E-01 2.2E-01 > 0.05

BP response to other organism 897 15 1.7 4.3E-01 3.3E-01 > 0.05

BP negative regulation of apoptosis 897 18 2.0 4.3E-01 3.4E-01 > 0.05

BP antigen processing and presentation of peptide or

polysaccharide antigen via MHC class II

897 3 0.3 4.4E-01 1.8E-01 > 0.05

BP phospholipid transport 897 3 0.3 4.4E-01 1.8E-01 > 0.05

BP antigen receptor-mediated signaling pathway 897 3 0.3 4.4E-01 1.8E-01 > 0.05

BP positive regulation of myeloid cell differentiation 897 3 0.3 4.4E-01 1.8E-01 > 0.05

BP adult locomotory behavior 897 4 0.5 4.4E-01 2.3E-01 > 0.05

BP cellular amino acid derivative biosynthetic process 897 4 0.5 4.4E-01 2.3E-01 > 0.05

BP positive regulation of lipase activity 897 5 0.6 4.4E-01 2.5E-01 > 0.05

BP positive regulation of lymphocyte activation 897 6 0.7 4.4E-01 2.7E-01 > 0.05

BP biogenic amine metabolic process 897 6 0.7 4.4E-01 2.7E-01 > 0.05

BP glycerophospholipid metabolic process 897 7 0.8 4.4E-01 2.8E-01 > 0.05

BP transcription, DNA-dependent 897 15 1.7 4.4E-01 3.4E-01 > 0.05

BP cellular nitrogen compound metabolic process 897 168 18.9 4.4E-01 4.2E-01 > 0.05

BP positive regulation of lymphocyte proliferation 897 4 0.5 4.5E-01 2.3E-01 > 0.05

BP negative regulation of cytoskeleton organization 897 4 0.5 4.5E-01 2.3E-01 > 0.05

BP cell recognition 897 4 0.5 4.5E-01 2.3E-01 > 0.05

BP digestive system process 897 3 0.3 4.6E-01 2.0E-01 > 0.05

BP negative regulation of protein complex assembly 897 3 0.3 4.6E-01 2.0E-01 > 0.05

BP unsaturated fatty acid biosynthetic process 897 3 0.3 4.6E-01 2.0E-01 > 0.05

BP positive regulation of leukocyte proliferation 897 4 0.5 4.6E-01 2.4E-01 > 0.05

BP gene silencing 897 4 0.5 4.6E-01 2.4E-01 > 0.05

BP positive regulation of mononuclear cell proliferation 897 4 0.5 4.6E-01 2.4E-01 > 0.05

BP positive regulation of DNA metabolic process 897 4 0.5 4.6E-01 2.4E-01 > 0.05

BP regulation of gene expression, epigenetic 897 5 0.6 4.6E-01 2.7E-01 > 0.05

BP limb morphogenesis 897 6 0.7 4.6E-01 2.9E-01 > 0.05

BP regulation of Rho protein signal transduction 897 6 0.7 4.6E-01 2.9E-01 > 0.05

BP lung development 897 6 0.7 4.6E-01 2.9E-01 > 0.05

BP appendage morphogenesis 897 6 0.7 4.6E-01 2.9E-01 > 0.05

BP negative regulation of cell size 897 6 0.7 4.6E-01 2.9E-01 > 0.05

BP negative regulation of cellular component organization 897 8 0.9 4.6E-01 3.1E-01 > 0.05

BP regulation of cellular component biogenesis 897 8 0.9 4.6E-01 3.1E-01 > 0.05

BP vasculature development 897 13 1.5 4.6E-01 3.4E-01 > 0.05

BP RNA biosynthetic process 897 15 1.7 4.6E-01 3.6E-01 > 0.05

BP positive regulation of gene expression 897 28 3.2 4.6E-01 3.9E-01 > 0.05

BP anatomical structure morphogenesis 897 56 6.3 4.6E-01 4.0E-01 > 0.05

BP pancreas development 897 3 0.3 4.7E-01 2.1E-01 > 0.05

BP positive regulation of lymphocyte differentiation 897 3 0.3 4.7E-01 2.1E-01 > 0.05

BP ureteric bud development 897 3 0.3 4.7E-01 2.1E-01 > 0.05

BP metencephalon development 897 3 0.3 4.7E-01 2.1E-01 > 0.05

BP positive regulation of protein complex assembly 897 3 0.3 4.7E-01 2.1E-01 > 0.05

BP regulation of fibroblast proliferation 897 3 0.3 4.7E-01 2.1E-01 > 0.05

BP immune system development 897 14 1.6 4.7E-01 3.7E-01 > 0.05

BP fatty acid biosynthetic process 897 5 0.6 4.8E-01 2.8E-01 > 0.05

BP sterol metabolic process 897 6 0.7 4.8E-01 3.0E-01 > 0.05

BP transcription from RNA polymerase II promoter 897 12 1.4 4.8E-01 3.7E-01 > 0.05

BP induction of apoptosis 897 16 1.8 4.8E-01 3.7E-01 > 0.05

BP induction of programmed cell death 897 16 1.8 4.8E-01 3.8E-01 > 0.05

BP positive regulation of transcription 897 27 3.0 4.8E-01 4.0E-01 > 0.05

BP cell projection organization 897 18 2.0 4.8E-01 4.0E-01 > 0.05

BP negative regulation of MAP kinase activity 897 3 0.3 4.9E-01 2.2E-01 > 0.05

BP leukocyte activation during immune response 897 3 0.3 4.9E-01 2.2E-01 > 0.05

BP positive regulation of hormone secretion 897 3 0.3 4.9E-01 2.2E-01 > 0.05

BP regulation of steroid metabolic process 897 3 0.3 4.9E-01 2.2E-01 > 0.05

BP negative regulation of defense response 897 3 0.3 4.9E-01 2.2E-01 > 0.05

BP cell activation during immune response 897 3 0.3 4.9E-01 2.2E-01 > 0.05

BP regulation of nucleocytoplasmic transport 897 4 0.5 4.9E-01 2.6E-01 > 0.05

BP cell differentiation 897 75 8.5 4.9E-01 4.5E-01 > 0.05

BP JNK cascade 897 4 0.5 5.0E-01 2.7E-01 > 0.05

BP appendage development 897 6 0.7 5.0E-01 3.2E-01 > 0.05

BP limb development 897 6 0.7 5.0E-01 3.2E-01 > 0.05

BP reproductive structure development 897 7 0.8 5.0E-01 3.4E-01 > 0.05

BP T cell activation 897 7 0.8 5.0E-01 3.4E-01 > 0.05

BP response to bacterium 897 10 1.1 5.0E-01 3.7E-01 > 0.05

BP hemopoiesis 897 12 1.4 5.0E-01 3.8E-01 > 0.05

BP mitotic cell cycle 897 18 2.0 5.0E-01 4.1E-01 > 0.05

BP regulation of endopeptidase activity 897 5 0.6 5.1E-01 3.1E-01 > 0.05

BP negative regulation of organelle organization 897 5 0.6 5.1E-01 3.1E-01 > 0.05

BP response to estrogen stimulus 897 6 0.7 5.1E-01 3.4E-01 > 0.05

BP tube morphogenesis 897 7 0.8 5.1E-01 3.5E-01 > 0.05

BP response to drug 897 11 1.2 5.1E-01 3.8E-01 > 0.05

BP Rho protein signal transduction 897 3 0.3 5.2E-01 2.4E-01 > 0.05

BP regulation of actin polymerization or depolymerization 897 4 0.5 5.2E-01 3.0E-01 > 0.05

BP regulation of lymphocyte proliferation 897 5 0.6 5.2E-01 3.2E-01 > 0.05

BP cell projection assembly 897 5 0.6 5.2E-01 3.2E-01 > 0.05

BP response to temperature stimulus 897 5 0.6 5.2E-01 3.2E-01 > 0.05

BP neurotransmitter transport 897 5 0.6 5.2E-01 3.2E-01 > 0.05

BP antigen processing and presentation 897 5 0.6 5.2E-01 3.2E-01 > 0.05

BP hormone metabolic process 897 6 0.7 5.2E-01 3.4E-01 > 0.05

BP regulation of hormone levels 897 8 0.9 5.2E-01 3.7E-01 > 0.05

BP DNA repair 897 14 1.6 5.2E-01 4.0E-01 > 0.05

BP anatomical structure formation involved in morphogenesis 897 17 1.9 5.2E-01 4.2E-01 > 0.05

BP cell cycle 897 36 4.1 5.2E-01 4.4E-01 > 0.05

BP regulation of muscle cell differentiation 897 3 0.3 5.3E-01 2.6E-01 > 0.05

BP spinal cord development 897 3 0.3 5.3E-01 2.6E-01 > 0.05

BP neuromuscular process 897 4 0.5 5.3E-01 3.1E-01 > 0.05

BP regulation of mononuclear cell proliferation 897 5 0.6 5.3E-01 3.3E-01 > 0.05

BP regulation of leukocyte proliferation 897 5 0.6 5.3E-01 3.3E-01 > 0.05

BP response to protein stimulus 897 6 0.7 5.3E-01 3.5E-01 > 0.05

BP regulation of cell activation 897 9 1.0 5.3E-01 3.9E-01 > 0.05

BP regulation of actin filament length 897 4 0.5 5.4E-01 3.2E-01 > 0.05

BP regulation of angiogenesis 897 4 0.5 5.4E-01 3.2E-01 > 0.05

BP cell redox homeostasis 897 4 0.5 5.4E-01 3.2E-01 > 0.05

BP stress-activated protein kinase signaling pathway 897 4 0.5 5.4E-01 3.2E-01 > 0.05

BP I-kappaB kinase/NF-kappaB cascade 897 4 0.5 5.4E-01 3.2E-01 > 0.05

BP homophilic cell adhesion 897 7 0.8 5.4E-01 3.8E-01 > 0.05

BP in utero embryonic development 897 9 1.0 5.4E-01 4.0E-01 > 0.05

BP positive regulation of multicellular organismal process 897 12 1.4 5.4E-01 4.2E-01 > 0.05

BP protein import into nucleus 897 5 0.6 5.5E-01 3.5E-01 > 0.05

BP regulation of peptidase activity 897 5 0.6 5.5E-01 3.5E-01 > 0.05

BP response to virus 897 6 0.7 5.5E-01 3.7E-01 > 0.05

BP negative regulation of growth 897 6 0.7 5.5E-01 3.8E-01 > 0.05

BP aging 897 6 0.7 5.5E-01 3.8E-01 > 0.05

BP elevation of cytosolic calcium ion concentration 897 6 0.7 5.5E-01 3.8E-01 > 0.05

BP blood vessel development 897 12 1.4 5.5E-01 4.3E-01 > 0.05

BP nitrogen compound metabolic process 897 170 19.2 5.5E-01 5.2E-01 > 0.05

BP regulation of myeloid leukocyte differentiation 897 3 0.3 5.6E-01 2.8E-01 > 0.05

BP ovarian follicle development 897 3 0.3 5.6E-01 2.8E-01 > 0.05

BP negative regulation of protein complex disassembly 897 3 0.3 5.6E-01 2.8E-01 > 0.05

BP positive regulation of epithelial cell proliferation 897 3 0.3 5.6E-01 2.8E-01 > 0.05

BP branching morphogenesis of a tube 897 4 0.5 5.6E-01 3.4E-01 > 0.05

BP nuclear import 897 5 0.6 5.6E-01 3.6E-01 > 0.05

BP organic acid catabolic process 897 6 0.7 5.6E-01 3.8E-01 > 0.05

BP carboxylic acid catabolic process 897 6 0.7 5.6E-01 3.8E-01 > 0.05

BP nucleocytoplasmic transport 897 8 0.9 5.6E-01 4.1E-01 > 0.05

BP positive regulation of hydrolase activity 897 9 1.0 5.6E-01 4.2E-01 > 0.05

BP regulation of cellular localization 897 12 1.4 5.6E-01 4.5E-01 > 0.05

BP negative regulation of cell proliferation 897 17 1.9 5.6E-01 4.6E-01 > 0.05

BP response to biotic stimulus 897 18 2.0 5.6E-01 4.7E-01 > 0.05

BP cellular developmental process 897 77 8.7 5.6E-01 5.1E-01 > 0.05

BP response to cAMP 897 3 0.3 5.7E-01 2.9E-01 > 0.05

BP positive regulation of cell growth 897 3 0.3 5.7E-01 2.9E-01 > 0.05

BP determination of left/right symmetry 897 3 0.3 5.7E-01 2.9E-01 > 0.05

BP cell-matrix adhesion 897 5 0.6 5.7E-01 3.7E-01 > 0.05

BP induction of apoptosis by extracellular signals 897 6 0.7 5.7E-01 3.9E-01 > 0.05

BP one-carbon metabolic process 897 6 0.7 5.7E-01 3.9E-01 > 0.05

BP defense response to bacterium 897 6 0.7 5.7E-01 3.9E-01 > 0.05

BP regulation of lipid metabolic process 897 6 0.7 5.7E-01 3.9E-01 > 0.05

BP regulation of immune response 897 11 1.2 5.7E-01 4.4E-01 > 0.05

BP cellular localization 897 42 4.7 5.7E-01 5.1E-01 > 0.05

BP negative regulation of cell adhesion 897 3 0.3 5.8E-01 3.1E-01 > 0.05

BP determination of bilateral symmetry 897 3 0.3 5.8E-01 3.1E-01 > 0.05

BP determination of symmetry 897 3 0.3 5.8E-01 3.1E-01 > 0.05

BP amino acid transport 897 5 0.6 5.8E-01 3.8E-01 > 0.05

BP regulation of response to external stimulus 897 8 0.9 5.8E-01 4.3E-01 > 0.05

BP protein modification by small protein conjugation or removal 897 8 0.9 5.8E-01 4.3E-01 > 0.05

BP regulation of cell development 897 10 1.1 5.8E-01 4.4E-01 > 0.05

BP growth 897 9 1.0 5.8E-01 4.4E-01 > 0.05

BP regulation of small GTPase mediated signal transduction 897 12 1.4 5.8E-01 4.6E-01 > 0.05

BP cellular carbohydrate metabolic process 897 18 2.0 5.8E-01 4.8E-01 > 0.05

BP regulation of biological quality 897 66 7.4 5.8E-01 5.3E-01 > 0.05

BP positive regulation of immune effector process 897 3 0.3 5.9E-01 3.2E-01 > 0.05

BP protein amino acid N-linked glycosylation 897 3 0.3 5.9E-01 3.2E-01 > 0.05

BP camera-type eye morphogenesis 897 3 0.3 5.9E-01 3.2E-01 > 0.05

BP regulation of protein import into nucleus 897 3 0.3 5.9E-01 3.2E-01 > 0.05

BP epithelial tube morphogenesis 897 4 0.5 5.9E-01 3.6E-01 > 0.05

BP regulation of protein transport 897 6 0.7 5.9E-01 4.1E-01 > 0.05

BP regulation of DNA metabolic process 897 6 0.7 5.9E-01 4.1E-01 > 0.05

BP microtubule-based process 897 12 1.4 5.9E-01 4.7E-01 > 0.05

BP cytoskeleton organization 897 20 2.3 5.9E-01 5.0E-01 > 0.05

BP cellular response to stimulus 897 37 4.2 5.9E-01 5.2E-01 > 0.05

BP regulation of protein polymerization 897 4 0.5 6.0E-01 3.7E-01 > 0.05

BP circulatory system process 897 9 1.0 6.0E-01 4.6E-01 > 0.05

BP blood circulation 897 9 1.0 6.0E-01 4.6E-01 > 0.05

BP neuron differentiation 897 20 2.3 6.0E-01 5.0E-01 > 0.05

BP cell development 897 29 3.3 6.0E-01 5.3E-01 > 0.05

BP spindle organization 897 3 0.3 6.1E-01 3.3E-01 > 0.05

BP negative regulation of phosphorylation 897 3 0.3 6.1E-01 3.3E-01 > 0.05

BP cellular carbohydrate biosynthetic process 897 4 0.5 6.1E-01 3.8E-01 > 0.05

BP eye morphogenesis 897 4 0.5 6.1E-01 3.8E-01 > 0.05

BP endocrine system development 897 4 0.5 6.1E-01 3.8E-01 > 0.05

BP biopolymer methylation 897 4 0.5 6.1E-01 3.8E-01 > 0.05

BP negative regulation of protein metabolic process 897 9 1.0 6.1E-01 4.7E-01 > 0.05

BP response to DNA damage stimulus 897 17 1.9 6.1E-01 5.2E-01 > 0.05

BP response to stress 897 75 8.5 6.1E-01 5.6E-01 > 0.05

BP ribonucleoside metabolic process 897 3 0.3 6.2E-01 3.4E-01 > 0.05

BP regulation of smooth muscle cell proliferation 897 3 0.3 6.2E-01 3.4E-01 > 0.05

BP pallium development 897 3 0.3 6.2E-01 3.4E-01 > 0.05

BP protein localization in nucleus 897 5 0.6 6.2E-01 4.2E-01 > 0.05

BP cytosolic calcium ion homeostasis 897 6 0.7 6.2E-01 4.4E-01 > 0.05

BP amine transport 897 6 0.7 6.2E-01 4.4E-01 > 0.05

BP regulation of leukocyte activation 897 8 0.9 6.2E-01 4.7E-01 > 0.05

BP small GTPase mediated signal transduction 897 14 1.6 6.2E-01 5.1E-01 > 0.05

BP intracellular protein transport 897 17 1.9 6.2E-01 5.2E-01 > 0.05

BP regulation of intracellular transport 897 4 0.5 6.3E-01 4.0E-01 > 0.05

BP regulation of epithelial cell proliferation 897 4 0.5 6.3E-01 4.0E-01 > 0.05

BP negative regulation of protein modification process 897 6 0.7 6.3E-01 4.5E-01 > 0.05

BP wound healing 897 9 1.0 6.3E-01 4.9E-01 > 0.05

BP reproduction 897 34 3.8 6.3E-01 5.7E-01 > 0.05

BP negative regulation of phosphate metabolic process 897 3 0.3 6.4E-01 3.7E-01 > 0.05

BP segmentation 897 3 0.3 6.4E-01 3.7E-01 > 0.05

BP phagocytosis 897 3 0.3 6.4E-01 3.7E-01 > 0.05

BP RNA modification 897 3 0.3 6.4E-01 3.7E-01 > 0.05

BP positive regulation of cell size 897 3 0.3 6.4E-01 3.7E-01 > 0.05

BP B cell differentiation 897 3 0.3 6.4E-01 3.7E-01 > 0.05

BP negative regulation of phosphorus metabolic process 897 3 0.3 6.4E-01 3.7E-01 > 0.05

BP regulation of establishment of protein localization 897 6 0.7 6.4E-01 4.6E-01 > 0.05

BP response to steroid hormone stimulus 897 9 1.0 6.4E-01 5.0E-01 > 0.05

BP protein targeting 897 10 1.1 6.4E-01 5.1E-01 > 0.05

BP regulation of microtubule-based process 897 3 0.3 6.5E-01 3.8E-01 > 0.05

BP regulation of cytokine biosynthetic process 897 4 0.5 6.5E-01 4.3E-01 > 0.05

BP morphogenesis of a branching structure 897 4 0.5 6.5E-01 4.3E-01 > 0.05

BP cell-substrate adhesion 897 5 0.6 6.5E-01 4.5E-01 > 0.05

BP ubiquitin-dependent protein catabolic process 897 11 1.2 6.5E-01 5.3E-01 > 0.05

BP cell cycle process 897 25 2.8 6.5E-01 5.7E-01 > 0.05

BP cellular response to stress 897 25 2.8 6.5E-01 5.7E-01 > 0.05

BP sulfur compound biosynthetic process 897 3 0.3 6.6E-01 3.9E-01 > 0.05

BP negative regulation of response to external stimulus 897 3 0.3 6.6E-01 3.9E-01 > 0.05

BP vitamin metabolic process 897 4 0.5 6.6E-01 4.4E-01 > 0.05

BP regulation of protein ubiquitination 897 5 0.6 6.6E-01 4.7E-01 > 0.05

BP regulation of lymphocyte activation 897 7 0.8 6.6E-01 5.0E-01 > 0.05

BP cellular metal ion homeostasis 897 9 1.0 6.6E-01 5.3E-01 > 0.05

BP mitosis 897 10 1.1 6.6E-01 5.3E-01 > 0.05

BP membrane invagination 897 10 1.1 6.6E-01 5.3E-01 > 0.05

BP endocytosis 897 10 1.1 6.6E-01 5.3E-01 > 0.05

BP nuclear division 897 10 1.1 6.6E-01 5.3E-01 > 0.05

BP methylation 897 4 0.5 6.7E-01 4.5E-01 > 0.05

BP morphogenesis of an epithelium 897 5 0.6 6.7E-01 4.8E-01 > 0.05

BP regulation of immune effector process 897 5 0.6 6.7E-01 4.8E-01 > 0.05

BP germ cell development 897 5 0.6 6.7E-01 4.8E-01 > 0.05

BP lipid catabolic process 897 8 0.9 6.7E-01 5.2E-01 > 0.05

BP tissue development 897 29 3.3 6.7E-01 6.0E-01 > 0.05

BP mesenchymal cell differentiation 897 3 0.3 6.8E-01 4.1E-01 > 0.05

BP cellular amino acid biosynthetic process 897 3 0.3 6.8E-01 4.1E-01 > 0.05

BP mesenchymal cell development 897 3 0.3 6.8E-01 4.1E-01 > 0.05

BP positive regulation of transport 897 10 1.1 6.8E-01 5.5E-01 > 0.05

BP M phase of mitotic cell cycle 897 10 1.1 6.8E-01 5.6E-01 > 0.05

BP regulation of transport 897 19 2.1 6.8E-01 5.9E-01 > 0.05

BP reproductive process 897 33 3.7 6.8E-01 6.2E-01 > 0.05

BP mesenchyme development 897 3 0.3 6.9E-01 4.2E-01 > 0.05

BP hormone-mediated signaling 897 3 0.3 6.9E-01 4.2E-01 > 0.05

BP vesicle organization 897 3 0.3 6.9E-01 4.2E-01 > 0.05

BP amine catabolic process 897 4 0.5 6.9E-01 4.7E-01 > 0.05

BP regulation of Ras GTPase activity 897 5 0.6 6.9E-01 5.1E-01 > 0.05

BP regulation of secretion 897 9 1.0 6.9E-01 5.6E-01 > 0.05

BP actin cytoskeleton organization 897 10 1.1 6.9E-01 5.7E-01 > 0.05

BP locomotory behavior 897 12 1.4 6.9E-01 5.8E-01 > 0.05

BP glial cell differentiation 897 3 0.3 7.0E-01 4.3E-01 > 0.05

BP receptor-mediated endocytosis 897 3 0.3 7.0E-01 4.3E-01 > 0.05

BP fat cell differentiation 897 3 0.3 7.0E-01 4.3E-01 > 0.05

BP cellular polysaccharide metabolic process 897 3 0.3 7.0E-01 4.3E-01 > 0.05

BP peptide metabolic process 897 3 0.3 7.0E-01 4.3E-01 > 0.05

BP regulation of intracellular protein transport 897 3 0.3 7.0E-01 4.3E-01 > 0.05

BP inner ear development 897 4 0.5 7.0E-01 4.8E-01 > 0.05

BP secondary metabolic process 897 4 0.5 7.0E-01 4.8E-01 > 0.05

BP regulation of caspase activity 897 4 0.5 7.0E-01 4.8E-01 > 0.05

BP humoral immune response 897 4 0.5 7.0E-01 4.8E-01 > 0.05

BP spermatid development 897 3 0.3 7.1E-01 4.4E-01 > 0.05

BP response to estradiol stimulus 897 3 0.3 7.1E-01 4.4E-01 > 0.05

BP regulation of lymphocyte mediated immunity 897 3 0.3 7.1E-01 4.4E-01 > 0.05

BP regulation of cell shape 897 3 0.3 7.1E-01 4.4E-01 > 0.05

BP regulation of actin filament polymerization 897 3 0.3 7.1E-01 4.4E-01 > 0.05

BP regulation of cyclin-dependent protein kinase activity 897 3 0.3 7.1E-01 4.4E-01 > 0.05

BP nucleotide-excision repair 897 3 0.3 7.1E-01 4.5E-01 > 0.05

BP regulation of adaptive immune response based on somatic

recombination of immune receptors built from immunoglobulin

superfamily domains

897 3 0.3 7.1E-01 4.5E-01 > 0.05

BP negative regulation of secretion 897 3 0.3 7.1E-01 4.5E-01 > 0.05

BP amine biosynthetic process 897 4 0.5 7.1E-01 5.0E-01 > 0.05

BP protein modification by small protein conjugation 897 6 0.7 7.1E-01 5.5E-01 > 0.05

BP negative regulation of cellular protein metabolic process 897 8 0.9 7.1E-01 5.7E-01 > 0.05

BP metal ion homeostasis 897 9 1.0 7.1E-01 5.8E-01 > 0.05

BP organelle fission 897 10 1.1 7.1E-01 5.9E-01 > 0.05

BP behavior 897 20 2.3 7.1E-01 6.3E-01 > 0.05

BP response to stimulus 897 153 17.2 7.1E-01 6.9E-01 > 0.05

BP cellular amide metabolic process 897 3 0.3 7.2E-01 4.7E-01 > 0.05

BP response to heat 897 3 0.3 7.2E-01 4.7E-01 > 0.05

BP regulation of adaptive immune response 897 3 0.3 7.2E-01 4.7E-01 > 0.05

BP tissue remodeling 897 3 0.3 7.2E-01 4.7E-01 > 0.05

BP chromatin remodeling 897 3 0.3 7.2E-01 4.7E-01 > 0.05

BP carbohydrate biosynthetic process 897 5 0.6 7.2E-01 5.3E-01 > 0.05

BP embryonic organ morphogenesis 897 6 0.7 7.2E-01 5.6E-01 > 0.05

BP cellular calcium ion homeostasis 897 8 0.9 7.2E-01 5.9E-01 > 0.05

BP cellular amine metabolic process 897 13 1.5 7.2E-01 6.2E-01 > 0.05

BP cellular amino acid and derivative metabolic process 897 15 1.7 7.2E-01 6.3E-01 > 0.05

BP intracellular transport 897 28 3.2 7.2E-01 6.5E-01 > 0.05

BP embryonic skeletal system morphogenesis 897 3 0.3 7.3E-01 4.8E-01 > 0.05

BP cell junction organization 897 3 0.3 7.3E-01 4.8E-01 > 0.05

BP positive regulation of specific transcription

from RNA polymerase II promoter

897 3 0.3 7.3E-01 4.8E-01 > 0.05

BP negative regulation of cell migration 897 3 0.3 7.3E-01 4.8E-01 > 0.05

BP spermatid differentiation 897 3 0.3 7.3E-01 4.8E-01 > 0.05

BP transcription initiation 897 4 0.5 7.3E-01 5.2E-01 > 0.05

BP positive regulation of secretion 897 5 0.6 7.3E-01 5.5E-01 > 0.05

BP immune effector process 897 6 0.7 7.3E-01 5.6E-01 > 0.05

BP negative regulation of transport 897 6 0.7 7.3E-01 5.7E-01 > 0.05

BP gland development 897 6 0.7 7.3E-01 5.7E-01 > 0.05

BP potassium ion transport 897 7 0.8 7.3E-01 5.9E-01 > 0.05

BP regulation of Ras protein signal transduction 897 9 1.0 7.3E-01 6.1E-01 > 0.05

BP embryonic morphogenesis 897 13 1.5 7.3E-01 6.3E-01 > 0.05

BP interspecies interaction between organisms 897 12 1.4 7.3E-01 6.3E-01 > 0.05

BP morphogenesis of embryonic epithelium 897 3 0.3 7.4E-01 4.9E-01 > 0.05

BP positive regulation of protein ubiquitination 897 4 0.5 7.4E-01 5.3E-01 > 0.05

BP response to corticosteroid stimulus 897 4 0.5 7.4E-01 5.4E-01 > 0.05

BP generation of a signal involved in cell-cell signaling 897 4 0.5 7.4E-01 5.4E-01 > 0.05

BP regulation of cytoskeleton organization 897 6 0.7 7.4E-01 5.8E-01 > 0.05

BP glycerolipid metabolic process 897 7 0.8 7.4E-01 6.0E-01 > 0.05

BP gene expression 897 130 14.7 7.4E-01 7.1E-01 > 0.05

BP positive regulation of neurogenesis 897 3 0.3 7.5E-01 5.0E-01 > 0.05

BP cellular hormone metabolic process 897 3 0.3 7.5E-01 5.0E-01 > 0.05

BP adult behavior 897 4 0.5 7.5E-01 5.5E-01 > 0.05

BP skeletal system morphogenesis 897 5 0.6 7.5E-01 5.7E-01 > 0.05

BP innate immune response 897 6 0.7 7.5E-01 5.9E-01 > 0.05

BP response to oxidative stress 897 7 0.8 7.5E-01 6.1E-01 > 0.05

BP calcium ion homeostasis 897 8 0.9 7.5E-01 6.2E-01 > 0.05

BP vesicle-mediated transport 897 24 2.7 7.5E-01 6.8E-01 > 0.05

BP placenta development 897 3 0.3 7.6E-01 5.1E-01 > 0.05

BP positive regulation of gene-specific transcription 897 4 0.5 7.6E-01 5.6E-01 > 0.05

BP embryonic limb morphogenesis 897 4 0.5 7.6E-01 5.6E-01 > 0.05

BP developmental growth 897 4 0.5 7.6E-01 5.6E-01 > 0.05

BP embryonic appendage morphogenesis 897 4 0.5 7.6E-01 5.6E-01 > 0.05

BP actin filament-based process 897 10 1.1 7.6E-01 6.5E-01 > 0.05

BP response to wounding 897 22 2.5 7.6E-01 6.9E-01 > 0.05

BP cell growth 897 3 0.3 7.7E-01 5.2E-01 > 0.05

BP response to toxin 897 3 0.3 7.7E-01 5.2E-01 > 0.05

BP regulation of leukocyte mediated immunity 897 3 0.3 7.7E-01 5.2E-01 > 0.05

BP negative regulation of locomotion 897 3 0.3 7.7E-01 5.2E-01 > 0.05

BP ovulation cycle process 897 3 0.3 7.7E-01 5.3E-01 > 0.05

BP regulation of DNA replication 897 3 0.3 7.7E-01 5.3E-01 > 0.05

BP regulation of actin cytoskeleton organization 897 4 0.5 7.7E-01 5.7E-01 > 0.05

BP positive regulation of cell migration 897 4 0.5 7.7E-01 5.7E-01 > 0.05

BP G-protein signaling, coupled to cyclic

nucleotide second messenger

897 5 0.6 7.7E-01 6.0E-01 > 0.05

BP regulation of body fluid levels 897 6 0.7 7.7E-01 6.1E-01 > 0.05

BP axonogenesis 897 8 0.9 7.7E-01 6.5E-01 > 0.05

BP cell morphogenesis involved in differentiation 897 10 1.1 7.7E-01 6.7E-01 > 0.05

BP response to external stimulus 897 38 4.3 7.7E-01 7.2E-01 > 0.05

BP negative regulation of cell motion 897 3 0.3 7.8E-01 5.4E-01 > 0.05

BP regulation of neuron apoptosis 897 4 0.5 7.8E-01 5.8E-01 > 0.05

BP digestion 897 4 0.5 7.8E-01 5.9E-01 > 0.05

BP regulation of T cell activation 897 5 0.6 7.8E-01 6.1E-01 > 0.05

BP detection of stimulus 897 5 0.6 7.8E-01 6.2E-01 > 0.05

BP skeletal system development 897 13 1.5 7.8E-01 6.8E-01 > 0.05

BP response to abiotic stimulus 897 15 1.7 7.8E-01 6.9E-01 > 0.05

BP cellular homeostasis 897 19 2.1 7.8E-01 7.1E-01 > 0.05

BP positive regulation of response to external stimulus 897 3 0.3 7.9E-01 5.6E-01 > 0.05

BP female gonad development 897 3 0.3 7.9E-01 5.6E-01 > 0.05

BP response to ethanol 897 3 0.3 7.9E-01 5.6E-01 > 0.05

BP cellular response to extracellular stimulus 897 3 0.3 7.9E-01 5.6E-01 > 0.05

BP regulation of actin filament-based process 897 4 0.5 7.9E-01 6.0E-01 > 0.05

BP protein ubiquitination 897 5 0.6 7.9E-01 6.3E-01 > 0.05

BP lipid transport 897 6 0.7 7.9E-01 6.4E-01 > 0.05

BP synaptic transmission 897 12 1.4 7.9E-01 7.0E-01 > 0.05

BP chromatin modification 897 11 1.2 7.9E-01 7.0E-01 > 0.05

BP gliogenesis 897 3 0.3 8.0E-01 5.7E-01 > 0.05

BP myeloid cell differentiation 897 4 0.5 8.0E-01 6.1E-01 > 0.05

BP regulation of specific transcription from

RNA polymerase II promoter

897 4 0.5 8.0E-01 6.2E-01 > 0.05

BP histone modification 897 5 0.6 8.0E-01 6.5E-01 > 0.05

BP microtubule cytoskeleton organization 897 6 0.7 8.0E-01 6.6E-01 > 0.05

BP protein oligomerization 897 7 0.8 8.0E-01 6.7E-01 > 0.05

BP ectoderm development 897 8 0.9 8.0E-01 6.8E-01 > 0.05

BP cellular amino acid metabolic process 897 9 1.0 8.0E-01 6.9E-01 > 0.05

BP protein transport 897 31 3.5 8.0E-01 7.5E-01 > 0.05

BP regulation of neurotransmitter levels 897 3 0.3 8.1E-01 5.9E-01 > 0.05

BP ovulation cycle 897 3 0.3 8.1E-01 5.9E-01 > 0.05

BP ear development 897 4 0.5 8.1E-01 6.3E-01 > 0.05

BP regulation of catabolic process 897 4 0.5 8.1E-01 6.3E-01 > 0.05

BP regulation of GTPase activity 897 5 0.6 8.1E-01 6.6E-01 > 0.05

BP cellular di-, tri-valent inorganic cation homeostasis 897 9 1.0 8.1E-01 7.0E-01 > 0.05

BP steroid metabolic process 897 8 0.9 8.1E-01 7.0E-01 > 0.05

BP cellular cation homeostasis 897 10 1.1 8.1E-01 7.1E-01 > 0.05

BP protein localization 897 36 4.1 8.1E-01 7.6E-01 > 0.05

BP neural tube development 897 3 0.3 8.2E-01 6.0E-01 > 0.05

BP transcription initiation from RNA polymerase II promoter 897 3 0.3 8.2E-01 6.0E-01 > 0.05

BP cellular amino acid catabolic process 897 3 0.3 8.2E-01 6.0E-01 > 0.05

BP development of primary female sexual characteristics 897 3 0.3 8.2E-01 6.1E-01 > 0.05

BP female sex differentiation 897 3 0.3 8.2E-01 6.1E-01 > 0.05

BP coenzyme biosynthetic process 897 3 0.3 8.2E-01 6.1E-01 > 0.05

BP positive regulation of cell development 897 3 0.3 8.2E-01 6.1E-01 > 0.05

BP positive regulation of locomotion 897 4 0.5 8.2E-01 6.5E-01 > 0.05

BP covalent chromatin modification 897 5 0.6 8.2E-01 6.8E-01 > 0.05

BP coenzyme metabolic process 897 6 0.7 8.2E-01 6.9E-01 > 0.05

BP glucose metabolic process 897 6 0.7 8.2E-01 6.9E-01 > 0.05

BP neuron projection development 897 10 1.1 8.2E-01 7.2E-01 > 0.05

BP cell morphogenesis 897 14 1.6 8.2E-01 7.4E-01 > 0.05

BP male gamete generation 897 12 1.4 8.2E-01 7.4E-01 > 0.05

BP spermatogenesis 897 12 1.4 8.2E-01 7.4E-01 > 0.05

BP establishment of protein localization 897 31 3.5 8.2E-01 7.7E-01 > 0.05

BP cellular protein catabolic process 897 24 2.7 8.2E-01 7.7E-01 > 0.05

BP proteolysis 897 43 4.8 8.2E-01 7.8E-01 > 0.05

BP positive regulation of ubiquitin-protein ligase activity 897 3 0.3 8.3E-01 6.2E-01 > 0.05

BP homeostasis of number of cells 897 4 0.5 8.3E-01 6.7E-01 > 0.05

BP RNA localization 897 4 0.5 8.3E-01 6.7E-01 > 0.05

BP regulation of blood pressure 897 4 0.5 8.3E-01 6.7E-01 > 0.05

BP response to unfolded protein 897 3 0.3 8.4E-01 6.3E-01 > 0.05

BP phospholipid biosynthetic process 897 4 0.5 8.4E-01 6.8E-01 > 0.05

BP cyclic-nucleotide-mediated signaling 897 5 0.6 8.4E-01 7.0E-01 > 0.05

BP lipid localization 897 6 0.7 8.4E-01 7.2E-01 > 0.05

BP cell morphogenesis involved in neuron differentiation 897 8 0.9 8.4E-01 7.3E-01 > 0.05

BP epidermis development 897 7 0.8 8.4E-01 7.3E-01 > 0.05

BP neuron development 897 13 1.5 8.4E-01 7.6E-01 > 0.05

BP establishment of localization in cell 897 34 3.8 8.4E-01 8.0E-01 > 0.05

BP positive regulation of ligase activity 897 3 0.3 8.5E-01 6.5E-01 > 0.05

BP phosphoinositide metabolic process 897 3 0.3 8.5E-01 6.5E-01 > 0.05

BP heart morphogenesis 897 3 0.3 8.5E-01 6.5E-01 > 0.05

BP detection of external stimulus 897 3 0.3 8.5E-01 6.5E-01 > 0.05

BP regulation of cell morphogenesis 897 5 0.6 8.5E-01 7.1E-01 > 0.05

BP protein import 897 5 0.6 8.5E-01 7.1E-01 > 0.05

BP Golgi vesicle transport 897 5 0.6 8.5E-01 7.1E-01 > 0.05

BP neuron projection morphogenesis 897 8 0.9 8.5E-01 7.5E-01 > 0.05

BP di-, tri-valent inorganic cation homeostasis 897 9 1.0 8.5E-01 7.6E-01 > 0.05

BP nucleobase, nucleoside and nucleotide metabolic process 897 12 1.4 8.5E-01 7.7E-01 > 0.05

BP oxidation reduction 897 25 2.8 8.5E-01 8.0E-01 > 0.05

BP organelle organization 897 54 6.1 8.5E-01 8.2E-01 > 0.05

BP positive regulation of T cell activation 897 3 0.3 8.6E-01 6.7E-01 > 0.05

BP Ras protein signal transduction 897 4 0.5 8.6E-01 7.0E-01 > 0.05

BP response to hypoxia 897 5 0.6 8.6E-01 7.3E-01 > 0.05

BP regulation of gene-specific transcription 897 5 0.6 8.6E-01 7.3E-01 > 0.05

BP reproductive cellular process 897 6 0.7 8.6E-01 7.4E-01 > 0.05

BP DNA replication 897 7 0.8 8.6E-01 7.6E-01 > 0.05

BP protein catabolic process 897 24 2.7 8.6E-01 8.1E-01 > 0.05

BP regulation of ubiquitin-protein ligase activity 897 3 0.3 8.7E-01 6.9E-01 > 0.05

BP regulation of cell adhesion 897 5 0.6 8.7E-01 7.5E-01 > 0.05

BP mitochondrion organization 897 5 0.6 8.7E-01 7.5E-01 > 0.05

BP cell projection morphogenesis 897 9 1.0 8.7E-01 7.8E-01 > 0.05

BP response to extracellular stimulus 897 8 0.9 8.7E-01 7.8E-01 > 0.05

BP amine metabolic process 897 15 1.7 8.7E-01 8.0E-01 > 0.05

BP transmission of nerve impulse 897 13 1.5 8.7E-01 8.0E-01 > 0.05

BP secretion 897 11 1.2 8.7E-01 8.0E-01 > 0.05

BP homeostatic process 897 29 3.3 8.7E-01 8.3E-01 > 0.05

BP fertilization 897 3 0.3 8.8E-01 7.0E-01 > 0.05

BP regulation of ligase activity 897 3 0.3 8.8E-01 7.1E-01 > 0.05

BP chromosome segregation 897 3 0.3 8.8E-01 7.1E-01 > 0.05

BP alcohol catabolic process 897 3 0.3 8.8E-01 7.1E-01 > 0.05

BP negative regulation of cell cycle 897 3 0.3 8.8E-01 7.1E-01 > 0.05

BP response to nutrient 897 5 0.6 8.8E-01 7.6E-01 > 0.05

BP response to oxygen levels 897 5 0.6 8.8E-01 7.7E-01 > 0.05

BP response to nutrient levels 897 7 0.8 8.8E-01 7.9E-01 > 0.05

BP protein complex biogenesis 897 19 2.1 8.8E-01 8.2E-01 > 0.05

BP protein complex assembly 897 19 2.1 8.8E-01 8.2E-01 > 0.05

BP carbohydrate metabolic process 897 20 2.3 8.8E-01 8.2E-01 > 0.05

BP sexual reproduction 897 17 1.9 8.8E-01 8.3E-01 > 0.05

BP nucleobase, nucleoside, nucleotide and

nucleic acid transport

897 4 0.5 8.9E-01 7.6E-01 > 0.05

BP calcium ion transport 897 5 0.6 8.9E-01 7.7E-01 > 0.05

BP epithelium development 897 8 0.9 8.9E-01 8.1E-01 > 0.05

BP cell part morphogenesis 897 9 1.0 8.9E-01 8.2E-01 > 0.05

BP regulation of system process 897 11 1.2 8.9E-01 8.3E-01 > 0.05

BP macromolecule localization 897 42 4.7 8.9E-01 8.6E-01 > 0.05

BP cellular carbohydrate catabolic process 897 3 0.3 9.0E-01 7.4E-01 > 0.05

BP G-protein signaling, coupled to cAMP nucleotide

second messenger

897 3 0.3 9.0E-01 7.4E-01 > 0.05

BP steroid biosynthetic process 897 3 0.3 9.0E-01 7.4E-01 > 0.05

BP leukocyte mediated immunity 897 3 0.3 9.0E-01 7.5E-01 > 0.05

BP protein localization in organelle 897 5 0.6 9.0E-01 7.9E-01 > 0.05

BP carboxylic acid transport 897 5 0.6 9.0E-01 8.0E-01 > 0.05

BP organic acid transport 897 5 0.6 9.0E-01 8.0E-01 > 0.05

BP di-, tri-valent inorganic cation transport 897 6 0.7 9.0E-01 8.1E-01 > 0.05

BP response to inorganic substance 897 7 0.8 9.0E-01 8.2E-01 > 0.05

BP cation homeostasis 897 10 1.1 9.0E-01 8.4E-01 > 0.05

BP catabolic process 897 49 5.5 9.0E-01 8.7E-01 > 0.05

BP mRNA transport 897 3 0.3 9.1E-01 7.6E-01 > 0.05

BP regulation of cell projection organization 897 3 0.3 9.1E-01 7.7E-01 > 0.05

BP response to organic cyclic substance 897 4 0.5 9.1E-01 8.0E-01 > 0.05

BP anti-apoptosis 897 7 0.8 9.1E-01 8.3E-01 > 0.05

BP secretion by cell 897 7 0.8 9.1E-01 8.3E-01 > 0.05

BP tissue morphogenesis 897 6 0.7 9.1E-01 8.3E-01 > 0.05

BP gamete generation 897 14 1.6 9.1E-01 8.6E-01 > 0.05

BP cellular component morphogenesis 897 14 1.6 9.1E-01 8.6E-01 > 0.05

BP modification-dependent protein catabolic process 897 21 2.4 9.1E-01 8.7E-01 > 0.05

BP modification-dependent macromolecule catabolic process 897 21 2.4 9.1E-01 8.7E-01 > 0.05

BP proteolysis involved in cellular protein catabolic process 897 22 2.5 9.1E-01 8.7E-01 > 0.05

BP cellular catabolic process 897 39 4.4 9.1E-01 8.9E-01 > 0.05

BP cell cycle checkpoint 897 3 0.3 9.2E-01 7.8E-01 > 0.05

BP organelle localization 897 3 0.3 9.2E-01 7.9E-01 > 0.05

BP muscle tissue development 897 4 0.5 9.2E-01 8.2E-01 > 0.05

BP muscle organ development 897 7 0.8 9.2E-01 8.4E-01 > 0.05

BP nucleotide metabolic process 897 10 1.1 9.2E-01 8.6E-01 > 0.05

BP nucleoside phosphate metabolic process 897 10 1.1 9.2E-01 8.6E-01 > 0.05

BP cellular ion homeostasis 897 13 1.5 9.2E-01 8.7E-01 > 0.05

BP alcohol metabolic process 897 15 1.7 9.2E-01 8.8E-01 > 0.05

BP chromatin organization 897 13 1.5 9.2E-01 8.8E-01 > 0.05

BP nucleosome organization 897 3 0.3 9.3E-01 8.0E-01 > 0.05

BP cAMP-mediated signaling 897 3 0.3 9.3E-01 8.1E-01 > 0.05

BP response to metal ion 897 4 0.5 9.3E-01 8.4E-01 > 0.05

BP chemotaxis 897 5 0.6 9.3E-01 8.5E-01 > 0.05

BP taxis 897 5 0.6 9.3E-01 8.5E-01 > 0.05

BP cellular chemical homeostasis 897 13 1.5 9.3E-01 8.8E-01 > 0.05

BP reproductive process in a multicellular organism 897 17 1.9 9.3E-01 8.9E-01 > 0.05

BP multicellular organism reproduction 897 17 1.9 9.3E-01 8.9E-01 > 0.05

BP cellular component organization 897 100 11.3 9.3E-01 9.2E-01 > 0.05

BP establishment of RNA localization 897 3 0.3 9.4E-01 8.2E-01 > 0.05

BP nucleic acid transport 897 3 0.3 9.4E-01 8.2E-01 > 0.05

BP cofactor biosynthetic process 897 3 0.3 9.4E-01 8.2E-01 > 0.05

BP RNA transport 897 3 0.3 9.4E-01 8.2E-01 > 0.05

BP regulation of ion transport 897 3 0.3 9.4E-01 8.3E-01 > 0.05

BP cellular protein complex assembly 897 5 0.6 9.4E-01 8.6E-01 > 0.05

BP hexose metabolic process 897 6 0.7 9.4E-01 8.7E-01 > 0.05

BP monosaccharide metabolic process 897 7 0.8 9.4E-01 8.8E-01 > 0.05

BP cofactor metabolic process 897 6 0.7 9.4E-01 8.8E-01 > 0.05

BP cellular macromolecule catabolic process 897 26 2.9 9.4E-01 9.1E-01 > 0.05

BP proteasomal protein catabolic process 897 3 0.3 9.5E-01 8.4E-01 > 0.05

BP blood coagulation 897 3 0.3 9.5E-01 8.4E-01 > 0.05

BP coagulation 897 3 0.3 9.5E-01 8.4E-01 > 0.05

BP proteasomal ubiquitin-dependent protein catabolic process 897 3 0.3 9.5E-01 8.4E-01 > 0.05

BP DNA recombination 897 3 0.3 9.5E-01 8.6E-01 > 0.05

BP anatomical structure homeostasis 897 3 0.3 9.5E-01 8.6E-01 > 0.05

BP regulation of synaptic transmission 897 4 0.5 9.5E-01 8.7E-01 > 0.05

BP cellular aromatic compound metabolic process 897 4 0.5 9.5E-01 8.7E-01 > 0.05

BP response to light stimulus 897 4 0.5 9.5E-01 8.7E-01 > 0.05

BP cell fate commitment 897 4 0.5 9.5E-01 8.8E-01 > 0.05

BP defense response 897 21 2.4 9.5E-01 9.3E-01 > 0.05

BP axon guidance 897 3 0.3 9.6E-01 8.7E-01 > 0.05

BP hemostasis 897 3 0.3 9.6E-01 8.7E-01 > 0.05

BP carbohydrate catabolic process 897 3 0.3 9.6E-01 8.7E-01 > 0.05

BP regulation of nucleotide biosynthetic process 897 3 0.3 9.6E-01 8.8E-01 > 0.05

BP regulation of cyclic nucleotide biosynthetic process 897 3 0.3 9.6E-01 8.8E-01 > 0.05

BP polysaccharide metabolic process 897 3 0.3 9.6E-01 8.8E-01 > 0.05

BP anion transport 897 4 0.5 9.6E-01 8.9E-01 > 0.05

BP regulation of transmission of nerve impulse 897 4 0.5 9.6E-01 9.0E-01 > 0.05

BP protein folding 897 5 0.6 9.6E-01 9.1E-01 > 0.05

BP inflammatory response 897 10 1.1 9.6E-01 9.2E-01 > 0.05

BP chromosome organization 897 16 1.8 9.6E-01 9.3E-01 > 0.05

BP chemical homeostasis 897 17 1.9 9.6E-01 9.3E-01 > 0.05

BP ion homeostasis 897 13 1.5 9.6E-01 9.3E-01 > 0.05

BP macromolecule catabolic process 897 27 3.0 9.6E-01 9.4E-01 > 0.05

BP regulation of cyclic nucleotide metabolic process 897 3 0.3 9.7E-01 8.9E-01 > 0.05

BP exocytosis 897 3 0.3 9.7E-01 9.0E-01 > 0.05

BP regulation of nucleotide metabolic process 897 3 0.3 9.7E-01 9.0E-01 > 0.05

BP DNA packaging 897 3 0.3 9.7E-01 9.0E-01 > 0.05

BP striated muscle tissue development 897 3 0.3 9.7E-01 9.1E-01 > 0.05

BP muscle cell differentiation 897 3 0.3 9.7E-01 9.1E-01 > 0.05

BP regulation of neurological system process 897 4 0.5 9.7E-01 9.2E-01 > 0.05

BP visual perception 897 6 0.7 9.7E-01 9.3E-01 > 0.05

BP sensory perception of light stimulus 897 6 0.7 9.7E-01 9.3E-01 > 0.05

BP purine nucleotide metabolic process 897 5 0.6 9.7E-01 9.3E-01 > 0.05

BP macromolecular complex subunit organization 897 24 2.7 9.7E-01 9.5E-01 > 0.05

BP ribosome biogenesis 897 3 0.3 9.8E-01 9.2E-01 > 0.05

BP chromatin assembly or disassembly 897 3 0.3 9.8E-01 9.3E-01 > 0.05

BP Wnt receptor signaling pathway 897 3 0.3 9.8E-01 9.4E-01 > 0.05

BP regulation of membrane potential 897 3 0.3 9.8E-01 9.4E-01 > 0.05

BP response to radiation 897 5 0.6 9.8E-01 9.5E-01 > 0.05

BP muscle system process 897 4 0.5 9.8E-01 9.5E-01 > 0.05

BP metal ion transport 897 14 1.6 9.8E-01 9.6E-01 > 0.05

BP G-protein coupled receptor protein signaling pathway 897 39 4.4 9.8E-01 9.7E-01 > 0.05

BP macromolecular complex assembly 897 21 2.4 9.8E-01 9.7E-01 > 0.05

BP RNA metabolic process 897 31 3.5 9.8E-01 9.8E-01 > 0.05

BP cellular component assembly 897 29 3.3 9.8E-01 9.8E-01 > 0.05

BP epithelial cell differentiation 897 3 0.3 9.9E-01 9.5E-01 > 0.05

BP posttranscriptional regulation of gene expression 897 5 0.6 9.9E-01 9.6E-01 > 0.05

BP energy derivation by oxidation of organic compounds 897 3 0.3 9.9E-01 9.6E-01 > 0.05

BP nucleotide biosynthetic process 897 4 0.5 9.9E-01 9.7E-01 > 0.05

BP ncRNA processing 897 4 0.5 9.9E-01 9.7E-01 > 0.05

BP muscle contraction 897 3 0.3 9.9E-01 9.7E-01 > 0.05

BP transmembrane transport 897 17 1.9 9.9E-01 9.8E-01 > 0.05

BP localization 897 114 12.9 9.9E-01 9.8E-01 > 0.05

BP monovalent inorganic cation transport 897 8 0.9 9.9E-01 9.8E-01 > 0.05

BP nitrogen compound biosynthetic process 897 8 0.9 9.9E-01 9.8E-01 > 0.05

BP nucleobase, nucleoside and nucleotide biosynthetic process 897 4 0.5 9.9E-01 9.8E-01 > 0.05

BP nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic

process

897 4 0.5 9.9E-01 9.8E-01 > 0.05

BP translation 897 8 0.9 9.9E-01 9.8E-01 > 0.05

BP cellular component biogenesis 897 32 3.6 9.9E-01 9.9E-01 > 0.05

BP heterocycle metabolic process 897 8 0.9 9.9E-01 9.9E-01 > 0.05

BP cellular macromolecular complex assembly 897 7 0.8 1.0E+00 9.9E-01 > 0.05

BP cellular macromolecular complex subunit organization 897 8 0.9 1.0E+00 9.9E-01 > 0.05

BP cation transport 897 14 1.6 1.0E+00 9.9E-01 > 0.05

BP ribonucleoprotein complex biogenesis 897 3 0.3 1.0E+00 9.9E-01 > 0.05

BP ncRNA metabolic process 897 4 0.5 1.0E+00 9.9E-01 > 0.05

BP transport 897 93 10.5 1.0E+00 1.0E+00 > 0.05

BP neurological system process 897 37 4.2 1.0E+00 1.0E+00 > 0.05

BP system process 897 48 5.4 1.0E+00 1.0E+00 > 0.05

BP establishment of localization 897 93 10.5 1.0E+00 1.0E+00 > 0.05

BP RNA splicing 897 5 0.6 1.0E+00 1.0E+00 > 0.05

BP cognition 897 24 2.7 1.0E+00 1.0E+00 > 0.05

BP RNA processing 897 12 1.4 1.0E+00 1.0E+00 > 0.05

BP mRNA processing 897 5 0.6 1.0E+00 1.0E+00 > 0.05

BP ion transport 897 18 2.0 1.0E+00 1.0E+00 > 0.05

BP mRNA metabolic process 897 6 0.7 1.0E+00 1.0E+00 > 0.05

BP sensory perception of smell 897 7 0.8 1.0E+00 1.0E+00 > 0.05

BP generation of precursor metabolites and energy 897 4 0.5 1.0E+00 1.0E+00 > 0.05

BP sensory perception of chemical stimulus 897 8 0.9 1.0E+00 1.0E+00 > 0.05

BP sensory perception 897 17 1.9 1.0E+00 1.0E+00 > 0.05

MF protein kinase activity 897 47 5.3 2.8E-04 1.5E-04 ######

MF transcription repressor activity 897 29 3.3 4.2E-04 1.9E-04 > 0.05

MF phosphotransferase activity, alcohol group as acceptor 897 50 5.6 2.0E-03 1.2E-03 > 0.05

MF transcription regulator activity 897 91 10.3 2.3E-03 1.6E-03 > 0.05

MF kinase activity 897 54 6.1 5.4E-03 3.5E-03 > 0.05

MF protein serine/threonine kinase activity 897 32 3.6 5.7E-03 3.2E-03 > 0.05

MF transferase activity, transferring phosphorus-containing groups 897 59 6.7 1.1E-02 7.9E-03 > 0.05

MF RNA polymerase II transcription factor activity 897 20 2.3 1.3E-02 6.4E-03 > 0.05

MF protein tyrosine kinase activity 897 15 1.7 1.6E-02 7.3E-03 > 0.05

MF transferase activity 897 97 10.9 1.6E-02 1.2E-02 > 0.05

MF sphingolipid binding 897 3 0.3 2.6E-02 1.6E-03 > 0.05

MF transcription factor activity 897 57 6.4 2.9E-02 2.0E-02 > 0.05

MF catalytic activity 897 254 28.6 3.7E-02 3.3E-02 > 0.05

MF enzyme activator activity 897 23 2.6 4.4E-02 2.7E-02 > 0.05

MF ribonucleotide binding 897 97 10.9 4.9E-02 4.0E-02 > 0.05

MF purine ribonucleotide binding 897 97 10.9 4.9E-02 4.0E-02 > 0.05

MF purine nucleotide binding 897 100 11.3 6.1E-02 5.0E-02 > 0.05

MF protein dimerization activity 897 33 3.7 6.3E-02 4.3E-02 > 0.05

MF tumor necrosis factor receptor binding 897 4 0.5 6.4E-02 1.3E-02 > 0.05

MF GTPase activator activity 897 16 1.8 6.6E-02 3.7E-02 > 0.05

MF molecular transducer activity 897 116 13.1 6.8E-02 5.7E-02 > 0.05

MF signal transducer activity 897 116 13.1 6.8E-02 5.7E-02 > 0.05

MF lipid binding 897 28 3.2 7.1E-02 4.7E-02 > 0.05

MF ligand-dependent nuclear receptor transcription coactivator

activity

897 5 0.6 7.4E-02 2.1E-02 > 0.05

MF adenyl ribonucleotide binding 897 79 8.9 7.6E-02 6.0E-02 > 0.05

MF transmembrane receptor protein tyrosine kinase activity 897 7 0.8 7.7E-02 2.9E-02 > 0.05

MF ATP binding 897 78 8.8 7.7E-02 6.1E-02 > 0.05

MF protein heterodimerization activity 897 15 1.7 8.1E-02 4.5E-02 > 0.05

MF SH2 domain binding 897 4 0.5 8.9E-02 2.0E-02 > 0.05

MF 3',5'-cyclic-nucleotide phosphodiesterase activity 897 4 0.5 8.9E-02 2.0E-02 > 0.05

MF adenyl nucleotide binding 897 82 9.2 9.2E-02 7.4E-02 > 0.05

MF insulin-like growth factor receptor binding 897 3 0.3 9.7E-02 1.4E-02 > 0.05

MF cyclic-nucleotide phosphodiesterase activity 897 4 0.5 9.7E-02 2.3E-02 > 0.05

MF cysteine-type endopeptidase activity 897 7 0.8 1.0E-01 4.1E-02 > 0.05

MF non-membrane spanning protein tyrosine kinase activity 897 5 0.6 1.1E-01 3.4E-02 > 0.05

MF phosphoric ester hydrolase activity 897 21 2.4 1.1E-01 7.1E-02 > 0.05

MF binding 897 570 64.3 1.1E-01 1.1E-01 > 0.05

MF purine nucleoside binding 897 82 9.2 1.2E-01 9.7E-02 > 0.05

MF nucleoside binding 897 82 9.2 1.3E-01 1.1E-01 > 0.05

MF purinergic nucleotide receptor activity, G-protein coupled 897 4 0.5 1.4E-01 3.8E-02 > 0.05

MF nucleotide receptor activity, G-protein coupled 897 4 0.5 1.4E-01 3.8E-02 > 0.05

MF nucleotide binding 897 111 12.5 1.4E-01 1.2E-01 > 0.05

MF DNA binding 897 115 13.0 1.4E-01 1.2E-01 > 0.05

MF tumor necrosis factor receptor superfamily binding 897 4 0.5 1.6E-01 4.7E-02 > 0.05

MF cytokine activity 897 13 1.5 1.6E-01 9.6E-02 > 0.05

MF SH3/SH2 adaptor activity 897 5 0.6 1.7E-01 6.6E-02 > 0.05

MF phosphoric diester hydrolase activity 897 7 0.8 1.7E-01 8.0E-02 > 0.05

MF kinase binding 897 12 1.4 1.7E-01 1.0E-01 > 0.05

MF growth factor activity 897 11 1.2 1.8E-01 1.0E-01 > 0.05

MF sequence-specific DNA binding 897 33 3.7 1.8E-01 1.4E-01 > 0.05

MF transmembrane receptor protein phosphatase activity 897 3 0.3 1.9E-01 4.4E-02 > 0.05

MF receptor binding 897 46 5.2 1.9E-01 1.5E-01 > 0.05

MF transcription corepressor activity 897 10 1.1 2.0E-01 1.1E-01 > 0.05

MF MHC class II receptor activity 897 3 0.3 2.1E-01 5.0E-02 > 0.05

MF MAP kinase kinase kinase activity 897 3 0.3 2.1E-01 5.0E-02 > 0.05

MF purinergic nucleotide receptor activity 897 4 0.5 2.1E-01 7.4E-02 > 0.05

MF nucleotide receptor activity 897 4 0.5 2.1E-01 7.4E-02 > 0.05

MF protein kinase binding 897 10 1.1 2.1E-01 1.2E-01 > 0.05

MF sialyltransferase activity 897 3 0.3 2.2E-01 5.7E-02 > 0.05

MF structural constituent of cytoskeleton 897 6 0.7 2.3E-01 1.1E-01 > 0.05

MF GTPase activity 897 13 1.5 2.3E-01 1.5E-01 > 0.05

MF protein homodimerization activity 897 19 2.1 2.3E-01 1.6E-01 > 0.05

MF enzyme regulator activity 897 43 4.8 2.3E-01 1.9E-01 > 0.05

MF protein binding, bridging 897 7 0.8 2.4E-01 1.3E-01 > 0.05

MF O-acyltransferase activity 897 4 0.5 2.5E-01 9.4E-02 > 0.05

MF pattern binding 897 10 1.1 2.5E-01 1.5E-01 > 0.05

MF polysaccharide binding 897 10 1.1 2.5E-01 1.5E-01 > 0.05

MF oxidoreductase activity, acting on paired donors, with

incorporation or reduction of molecular oxygen

897 9 1.0 2.5E-01 1.5E-01 > 0.05

MF transferase activity, transferring glycosyl groups 897 15 1.7 2.5E-01 1.7E-01 > 0.05

MF receptor activity 897 89 10.0 2.5E-01 2.2E-01 > 0.05

MF microtubule motor activity 897 6 0.7 2.6E-01 1.3E-01 > 0.05

MF monooxygenase activity 897 7 0.8 2.6E-01 1.4E-01 > 0.05

MF phospholipid binding 897 11 1.2 2.6E-01 1.7E-01 > 0.05

MF protein binding 897 372 41.9 2.6E-01 2.5E-01 > 0.05

MF oxidoreductase activity, acting on the aldehyde or oxo group of

donors, NAD or NADP as acceptor

897 3 0.3 2.7E-01 8.0E-02 > 0.05

MF isoprenoid binding 897 3 0.3 2.7E-01 8.0E-02 > 0.05

MF neuropeptide hormone activity 897 3 0.3 2.7E-01 8.0E-02 > 0.05

MF electron carrier activity 897 13 1.5 2.8E-01 1.9E-01 > 0.05

MF cysteine-type peptidase activity 897 9 1.0 2.9E-01 1.8E-01 > 0.05

MF metallopeptidase activity 897 11 1.2 3.0E-01 1.9E-01 > 0.05

MF nucleoside-triphosphatase regulator activity 897 22 2.5 3.0E-01 2.2E-01 > 0.05

MF GTP binding 897 20 2.3 3.0E-01 2.2E-01 > 0.05

MF hydrolase activity, acting on ester bonds 897 35 3.9 3.1E-01 2.5E-01 > 0.05

MF sugar transmembrane transporter activity 897 3 0.3 3.2E-01 1.1E-01 > 0.05

MF inositol or phosphatidylinositol phosphatase activity 897 3 0.3 3.2E-01 1.1E-01 > 0.05

MF protein tyrosine phosphatase activity 897 7 0.8 3.2E-01 1.8E-01 > 0.05

MF phosphatase activity 897 14 1.6 3.2E-01 2.2E-01 > 0.05

MF hydrolase activity 897 107 12.1 3.3E-01 2.9E-01 > 0.05

MF nucleic acid binding 897 151 17.0 3.3E-01 3.1E-01 > 0.05

MF transferase activity, transferring pentosyl groups 897 4 0.5 3.4E-01 1.5E-01 > 0.05

MF guanyl nucleotide binding 897 20 2.3 3.4E-01 2.6E-01 > 0.05

MF guanyl ribonucleotide binding 897 20 2.3 3.4E-01 2.6E-01 > 0.05

MF GTPase regulator activity 897 21 2.4 3.4E-01 2.6E-01 > 0.05

MF NAD or NADH binding 897 4 0.5 3.5E-01 1.6E-01 > 0.05

MF molecular adaptor activity 897 5 0.6 3.5E-01 1.8E-01 > 0.05

MF hormone receptor binding 897 6 0.7 3.5E-01 2.0E-01 > 0.05

MF oxidoreductase activity, acting on paired donors, with

incorporation or reduction of molecular oxygen, 2-oxoglutarate as

one donor, and incorporation of one atom each of oxygen into

both donors

897 3 0.3 3.6E-01 1.3E-01 > 0.05

MF magnesium ion binding 897 23 2.6 3.6E-01 2.8E-01 > 0.05

MF RNA polymerase II transcription mediator activity 897 3 0.3 3.7E-01 1.4E-01 > 0.05

MF general RNA polymerase II transcription factor activity 897 4 0.5 3.8E-01 1.8E-01 > 0.05

MF Ras GTPase activator activity 897 6 0.7 3.8E-01 2.2E-01 > 0.05

MF manganese ion binding 897 9 1.0 3.8E-01 2.5E-01 > 0.05

MF carbohydrate transmembrane transporter activity 897 3 0.3 3.9E-01 1.5E-01 > 0.05

MF serine-type endopeptidase inhibitor activity 897 6 0.7 3.9E-01 2.3E-01 > 0.05

MF kinase regulator activity 897 6 0.7 4.0E-01 2.3E-01 > 0.05

MF peptidase activity, acting on L-amino acid peptides 897 27 3.0 4.0E-01 3.3E-01 > 0.05

MF peptidase activity 897 28 3.2 4.1E-01 3.5E-01 > 0.05

MF thyroid hormone receptor binding 897 3 0.3 4.2E-01 1.7E-01 > 0.05

MF oxidoreductase activity, acting on the aldehyde or oxo group of

donors

897 3 0.3 4.2E-01 1.7E-01 > 0.05

MF actin filament binding 897 4 0.5 4.2E-01 2.1E-01 > 0.05

MF heat shock protein binding 897 5 0.6 4.2E-01 2.3E-01 > 0.05

MF carbohydrate binding 897 18 2.0 4.2E-01 3.2E-01 > 0.05

MF double-stranded RNA binding 897 3 0.3 4.3E-01 1.8E-01 > 0.05

MF monocarboxylic acid binding 897 4 0.5 4.3E-01 2.2E-01 > 0.05

MF glycosaminoglycan binding 897 8 0.9 4.3E-01 2.9E-01 > 0.05

MF enzyme inhibitor activity 897 14 1.6 4.3E-01 3.2E-01 > 0.05

MF transcription factor binding 897 25 2.8 4.3E-01 3.5E-01 > 0.05

MF motor activity 897 8 0.9 4.4E-01 3.0E-01 > 0.05

MF nuclear hormone receptor binding 897 5 0.6 4.5E-01 2.6E-01 > 0.05

MF phosphoprotein phosphatase activity 897 9 1.0 4.5E-01 3.1E-01 > 0.05

MF transcription cofactor activity 897 18 2.0 4.5E-01 3.5E-01 > 0.05

MF amino acid transmembrane transporter activity 897 4 0.5 4.9E-01 2.7E-01 > 0.05

MF sugar binding 897 10 1.1 5.0E-01 3.7E-01 > 0.05

MF endopeptidase activity 897 18 2.0 5.0E-01 4.1E-01 > 0.05

MF acetylglucosaminyltransferase activity 897 3 0.3 5.1E-01 2.4E-01 > 0.05

MF intramolecular oxidoreductase activity 897 3 0.3 5.1E-01 2.4E-01 > 0.05

MF N-acyltransferase activity 897 5 0.6 5.1E-01 3.1E-01 > 0.05

MF lyase activity 897 8 0.9 5.1E-01 3.6E-01 > 0.05

MF transferase activity, transferring hexosyl groups 897 9 1.0 5.1E-01 3.7E-01 > 0.05

MF RNA polymerase II transcription factor activity,

enhancer binding

897 3 0.3 5.2E-01 2.5E-01 > 0.05

MF hormone activity 897 6 0.7 5.3E-01 3.5E-01 > 0.05

MF amine receptor activity 897 3 0.3 5.5E-01 2.7E-01 > 0.05

MF steroid binding 897 4 0.5 5.5E-01 3.2E-01 > 0.05

MF UDP-glycosyltransferase activity 897 6 0.7 5.5E-01 3.7E-01 > 0.05

MF cofactor binding 897 12 1.4 5.5E-01 4.3E-01 > 0.05

MF transition metal ion binding 897 124 14.0 5.5E-01 5.1E-01 > 0.05

MF zinc ion binding 897 103 11.6 5.5E-01 5.1E-01 > 0.05

MF nuclease activity 897 8 0.9 5.6E-01 4.1E-01 > 0.05

MF coenzyme binding 897 9 1.0 5.6E-01 4.2E-01 > 0.05

MF transcription activator activity 897 19 2.1 5.6E-01 4.6E-01 > 0.05

MF identical protein binding 897 29 3.3 5.6E-01 4.8E-01 > 0.05

MF dioxygenase activity 897 4 0.5 5.7E-01 3.4E-01 > 0.05

MF oxidoreductase activity, acting on single donors with

incorporation of molecular oxygen, incorporation of two atoms of

oxygen

897 4 0.5 5.7E-01 3.4E-01 > 0.05

MF pyrophosphatase activity 897 34 3.8 5.7E-01 5.0E-01 > 0.05

MF specific RNA polymerase II transcription factor

activity

897 3 0.3 5.8E-01 3.0E-01 > 0.05

MF oxidoreductase activity, acting on single donors with incorporation

of molecular oxygen

897 4 0.5 5.8E-01 3.5E-01 > 0.05

MF hydrolase activity, acting on acid anhydrides, in

phosphorus-containing anhydrides

897 34 3.8 5.8E-01 5.2E-01 > 0.05

MF diacylglycerol binding 897 4 0.5 5.9E-01 3.6E-01 > 0.05

MF carboxylic acid transmembrane transporter activity 897 5 0.6 5.9E-01 3.9E-01 > 0.05

MF calmodulin binding 897 7 0.8 5.9E-01 4.3E-01 > 0.05

MF hydrolase activity, acting on acid anhydrides 897 34 3.8 5.9E-01 5.3E-01 > 0.05

MF organic acid transmembrane transporter activity 897 5 0.6 6.0E-01 4.0E-01 > 0.05

MF hydrolase activity, acting on glycosyl bonds 897 6 0.7 6.0E-01 4.2E-01 > 0.05

MF SMAD binding 897 3 0.3 6.1E-01 3.4E-01 > 0.05

MF protein domain specific binding 897 15 1.7 6.1E-01 5.1E-01 > 0.05

MF SH3 domain binding 897 5 0.6 6.2E-01 4.3E-01 > 0.05

MF iron ion binding 897 14 1.6 6.2E-01 5.1E-01 > 0.05

MF microtubule binding 897 4 0.5 6.3E-01 4.0E-01 > 0.05

MF endopeptidase inhibitor activity 897 7 0.8 6.3E-01 4.7E-01 > 0.05

MF nucleoside-triphosphatase activity 897 32 3.6 6.3E-01 5.6E-01 > 0.05

MF amine transmembrane transporter activity 897 4 0.5 6.4E-01 4.2E-01 > 0.05

MF hormone binding 897 3 0.3 6.5E-01 3.7E-01 > 0.05

MF transferase activity, transferring alkyl or aryl (other than methyl)

groups

897 3 0.3 6.5E-01 3.7E-01 > 0.05

MF sulfotransferase activity 897 3 0.3 6.5E-01 3.7E-01 > 0.05

MF ubiquitin thiolesterase activity 897 4 0.5 6.5E-01 4.3E-01 > 0.05

MF phosphoinositide binding 897 5 0.6 6.5E-01 4.6E-01 > 0.05

MF endonuclease activity 897 5 0.6 6.5E-01 4.6E-01 > 0.05

MF voltage-gated potassium channel activity 897 5 0.6 6.5E-01 4.6E-01 > 0.05

MF lipase activity 897 5 0.6 6.5E-01 4.6E-01 > 0.05

MF protein complex binding 897 9 1.0 6.5E-01 5.1E-01 > 0.05

MF metal cluster binding 897 3 0.3 6.6E-01 3.9E-01 > 0.05

MF iron-sulfur cluster binding 897 3 0.3 6.6E-01 3.9E-01 > 0.05

MF exopeptidase activity 897 4 0.5 6.7E-01 4.5E-01 > 0.05

MF heparin binding 897 5 0.6 6.8E-01 4.9E-01 > 0.05

MF oxidoreductase activity, acting on the CH-OH group of donors,

NAD or NADP as acceptor

897 5 0.6 6.8E-01 5.0E-01 > 0.05

MF metalloendopeptidase activity 897 5 0.6 6.8E-01 5.0E-01 > 0.05

MF potassium ion binding 897 6 0.7 6.8E-01 5.1E-01 > 0.05

MF peptidase inhibitor activity 897 7 0.8 6.8E-01 5.3E-01 > 0.05

MF small GTPase regulator activity 897 12 1.4 6.8E-01 5.6E-01 > 0.05

MF exonuclease activity 897 3 0.3 6.9E-01 4.2E-01 > 0.05

MF calcium channel activity 897 4 0.5 6.9E-01 4.7E-01 > 0.05

MF peptide binding 897 9 1.0 6.9E-01 5.5E-01 > 0.05

MF pyridoxal phosphate binding 897 3 0.3 7.0E-01 4.3E-01 > 0.05

MF vitamin B6 binding 897 3 0.3 7.0E-01 4.3E-01 > 0.05

MF protein kinase regulator activity 897 4 0.5 7.0E-01 4.9E-01 > 0.05

MF single-stranded DNA binding 897 3 0.3 7.1E-01 4.5E-01 > 0.05

MF acetyltransferase activity 897 4 0.5 7.1E-01 5.0E-01 > 0.05

MF potassium channel activity 897 6 0.7 7.1E-01 5.5E-01 > 0.05

MF phospholipase activity 897 4 0.5 7.2E-01 5.1E-01 > 0.05

MF cytokine binding 897 5 0.6 7.2E-01 5.4E-01 > 0.05

MF enzyme binding 897 22 2.5 7.2E-01 6.4E-01 > 0.05

MF G-protein-coupled receptor binding 897 5 0.6 7.3E-01 5.5E-01 > 0.05

MF symporter activity 897 6 0.7 7.3E-01 5.7E-01 > 0.05

MF transferase activity, transferring sulfur-containing groups 897 3 0.3 7.4E-01 4.8E-01 > 0.05

MF integrin binding 897 3 0.3 7.4E-01 4.9E-01 > 0.05

MF peptide receptor activity 897 5 0.6 7.5E-01 5.8E-01 > 0.05

MF peptide receptor activity, G-protein coupled 897 5 0.6 7.5E-01 5.8E-01 > 0.05

MF Ras guanyl-nucleotide exchange factor activity 897 4 0.5 7.6E-01 5.5E-01 > 0.05

MF oxidoreductase activity, acting on CH-OH group of donors 897 5 0.6 7.6E-01 5.9E-01 > 0.05

MF carboxylic acid binding 897 6 0.7 7.7E-01 6.2E-01 > 0.05

MF oxidoreductase activity 897 28 3.2 7.8E-01 7.2E-01 > 0.05

MF hydrolase activity, hydrolyzing O-glycosyl compounds 897 4 0.5 7.9E-01 6.1E-01 > 0.05

MF voltage-gated cation channel activity 897 6 0.7 7.9E-01 6.4E-01 > 0.05

MF transferase activity, transferring one-carbon groups 897 7 0.8 7.9E-01 6.5E-01 > 0.05

MF acyltransferase activity 897 8 0.9 8.0E-01 6.8E-01 > 0.05

MF transferase activity, transferring acyl groups other than amino-acyl

groups

897 8 0.9 8.0E-01 6.9E-01 > 0.05

MF guanyl-nucleotide exchange factor activity 897 6 0.7 8.1E-01 6.8E-01 > 0.05

MF N-acetyltransferase activity 897 3 0.3 8.2E-01 6.0E-01 > 0.05

MF tubulin binding 897 4 0.5 8.3E-01 6.6E-01 > 0.05

MF transferase activity, transferring acyl groups 897 8 0.9 8.3E-01 7.3E-01 > 0.05

MF FAD binding 897 3 0.3 8.4E-01 6.3E-01 > 0.05

MF thiolester hydrolase activity 897 4 0.5 8.4E-01 6.7E-01 > 0.05

MF transcription coactivator activity 897 8 0.9 8.4E-01 7.4E-01 > 0.05

MF Rho guanyl-nucleotide exchange factor activity 897 3 0.3 8.5E-01 6.5E-01 > 0.05

MF isomerase activity 897 5 0.6 8.5E-01 7.1E-01 > 0.05

MF transmembrane receptor activity 897 52 5.9 8.5E-01 8.2E-01 > 0.05

MF actin binding 897 12 1.4 8.6E-01 7.9E-01 > 0.05

MF cytoskeletal protein binding 897 19 2.1 8.6E-01 8.0E-01 > 0.05

MF cation binding 897 175 19.7 8.6E-01 8.4E-01 > 0.05

MF cation channel activity 897 10 1.1 8.7E-01 7.9E-01 > 0.05

MF metal ion binding 897 173 19.5 8.7E-01 8.5E-01 > 0.05

MF ion binding 897 177 20.0 8.7E-01 8.6E-01 > 0.05

MF methyltransferase activity 897 6 0.7 8.8E-01 7.7E-01 > 0.05

MF structure-specific DNA binding 897 5 0.6 8.9E-01 7.8E-01 > 0.05

MF secondary active transmembrane transporter activity 897 7 0.8 9.0E-01 8.2E-01 > 0.05

MF heme binding 897 4 0.5 9.1E-01 7.9E-01 > 0.05

MF chromatin binding 897 5 0.6 9.1E-01 8.0E-01 > 0.05

MF nucleotidyltransferase activity 897 4 0.5 9.2E-01 8.1E-01 > 0.05

MF metal ion transmembrane transporter activity 897 11 1.2 9.2E-01 8.7E-01 > 0.05

MF solute:cation symporter activity 897 3 0.3 9.3E-01 8.0E-01 > 0.05

MF carboxylesterase activity 897 3 0.3 9.3E-01 8.1E-01 > 0.05

MF tetrapyrrole binding 897 4 0.5 9.3E-01 8.3E-01 > 0.05

MF vitamin binding 897 4 0.5 9.3E-01 8.4E-01 > 0.05

MF ATPase activity 897 11 1.2 9.3E-01 8.8E-01 > 0.05

MF small GTPase binding 897 3 0.3 9.4E-01 8.3E-01 > 0.05

MF voltage-gated channel activity 897 6 0.7 9.4E-01 8.7E-01 > 0.05

MF voltage-gated ion channel activity 897 6 0.7 9.4E-01 8.7E-01 > 0.05

MF structural constituent of ribosome 897 5 0.6 9.4E-01 8.7E-01 > 0.05

MF alkali metal ion binding 897 7 0.8 9.4E-01 8.9E-01 > 0.05

MF growth factor binding 897 3 0.3 9.5E-01 8.5E-01 > 0.05

MF protein C-terminus binding 897 4 0.5 9.5E-01 8.8E-01 > 0.05

MF GTPase binding 897 3 0.3 9.6E-01 8.7E-01 > 0.05

MF amine binding 897 3 0.3 9.6E-01 8.7E-01 > 0.05

MF ATPase activity, coupled 897 8 0.9 9.6E-01 9.2E-01 > 0.05

MF active transmembrane transporter activity 897 11 1.2 9.6E-01 9.3E-01 > 0.05

MF calcium ion binding 897 32 3.6 9.6E-01 9.4E-01 > 0.05

MF G-protein coupled receptor activity 897 30 3.4 9.6E-01 9.5E-01 > 0.05

MF hydrolase activity, acting on carbon-nitrogen (but not peptide)

bonds

897 3 0.3 9.7E-01 8.9E-01 > 0.05

MF serine-type endopeptidase activity 897 4 0.5 9.7E-01 9.2E-01 > 0.05

MF ligand-gated channel activity 897 3 0.3 9.8E-01 9.3E-01 > 0.05

MF ligand-gated ion channel activity 897 3 0.3 9.8E-01 9.3E-01 > 0.05

MF small conjugating protein ligase activity 897 4 0.5 9.8E-01 9.4E-01 > 0.05

MF ligase activity, forming carbon-nitrogen bonds 897 6 0.7 9.8E-01 9.5E-01 > 0.05

MF acid-amino acid ligase activity 897 5 0.6 9.8E-01 9.5E-01 > 0.05

MF helicase activity 897 3 0.3 9.9E-01 9.5E-01 > 0.05

MF serine-type peptidase activity 897 4 0.5 9.9E-01 9.6E-01 > 0.05

MF serine hydrolase activity 897 4 0.5 9.9E-01 9.6E-01 > 0.05

MF ubiquitin-protein ligase activity 897 3 0.3 9.9E-01 9.6E-01 > 0.05

MF gated channel activity 897 8 0.9 9.9E-01 9.7E-01 > 0.05

MF cation transmembrane transporter activity 897 16 1.8 9.9E-01 9.8E-01 > 0.05

MF channel activity 897 11 1.2 9.9E-01 9.8E-01 > 0.05

MF passive transmembrane transporter activity 897 11 1.2 9.9E-01 9.8E-01 > 0.05

MF ion channel activity 897 10 1.1 9.9E-01 9.8E-01 > 0.05

MF ligase activity 897 10 1.1 9.9E-01 9.8E-01 > 0.05

MF substrate specific channel activity 897 10 1.1 9.9E-01 9.8E-01 > 0.05

MF structural molecule activity 897 17 1.9 1.0E+00 9.9E-01 > 0.05

MF transmembrane transporter activity 897 26 2.9 1.0E+00 1.0E+00 > 0.05

MF RNA binding 897 18 2.0 1.0E+00 1.0E+00 > 0.05

MF substrate-specific transmembrane transporter activity 897 21 2.4 1.0E+00 1.0E+00 > 0.05

MF ion transmembrane transporter activity 897 17 1.9 1.0E+00 1.0E+00 > 0.05

MF substrate-specific transporter activity 897 24 2.7 1.0E+00 1.0E+00 > 0.05

MF transporter activity 897 31 3.5 1.0E+00 1.0E+00 > 0.05

MF olfactory receptor activity 897 6 0.7 1.0E+00 1.0E+00 > 0.05

FA phosphoprotein 897 364 41.0 1.2E-05 1.0E-05 ######

FA Proto-oncogene 897 24 2.7 1.1E-04 4.1E-05 ######

FA phosphoric monoester hydrolase 897 11 1.2 5.8E-04 1.3E-04 ######

FA SH2 domain 897 14 1.6 7.8E-04 2.3E-04 > 0.05

FA polymorphism 897 524 59.1 2.9E-03 2.7E-03 > 0.05

FA serine/threonine-protein kinase 897 29 3.3 3.1E-03 1.6E-03 > 0.05

FA nucleotide-binding 897 94 10.6 3.8E-03 2.9E-03 > 0.05

FA transferase 897 79 8.9 5.7E-03 4.0E-03 > 0.05

FA kinase 897 44 5 6.3E-03 3.8E-03 > 0.05

FA tyrosine-specific phosphatase 897 6 0.7 8.9E-03 1.6E-03 > 0.05

FA atp-binding 897 74 8.3 1.0E-02 7.2E-03 > 0.05

FA heterodimer 897 11 1.2 1.1E-02 4.0E-03 > 0.05

FA Signal-anchor 897 29 3.3 1.1E-02 6.6E-03 > 0.05

FA transcription regulation 897 106 12 1.3E-02 1.0E-02 > 0.05

FA repressor 897 29 3.3 1.7E-02 1.0E-02 > 0.05

FA Transcription 897 107 12.1 1.7E-02 1.4E-02 > 0.05

FA activator 897 33 3.7 2.0E-02 1.3E-02 > 0.05

FA Homeobox 897 18 2 2.7E-02 1.4E-02 > 0.05

FA dna-binding 897 96 10.8 2.8E-02 2.3E-02 > 0.05

FA GTPase activation 897 13 1.5 3.6E-02 1.7E-02 > 0.05

FA camp 897 5 0.6 4.4E-02 1.0E-02 > 0.05

FA tyrosine-protein kinase 897 10 1.1 4.4E-02 1.9E-02 > 0.05

FA williams-beuren syndrome 897 4 0.5 4.9E-02 8.8E-03 > 0.05

FA autophosphorylation 897 6 0.7 5.4E-02 1.6E-02 > 0.05

FA alternative splicing 897 337 38 6.3E-02 5.8E-02 > 0.05

FA nucleus 897 199 22.4 6.7E-02 5.8E-02 > 0.05

FA ATP 897 16 1.8 7.3E-02 4.2E-02 > 0.05

FA tpr repeat 897 12 1.4 7.5E-02 3.8E-02 > 0.05

FA bromodomain 897 5 0.6 8.0E-02 2.3E-02 > 0.05

FA mitogen 897 5 0.6 8.0E-02 2.3E-02 > 0.05

FA growth factor 897 10 1.1 1.0E-01 5.0E-02 > 0.05

FA nad 897 13 1.5 1.0E-01 5.6E-02 > 0.05

FA gtp-binding 897 20 2.3 1.0E-01 6.4E-02 > 0.05

FA serine/threonine-specific protein kinase 897 6 0.7 1.1E-01 4.0E-02 > 0.05

FA sh3 domain 897 14 1.6 1.1E-01 6.1E-02 > 0.05

FA egf-like domain 897 15 1.7 1.1E-01 6.2E-02 > 0.05

FA cleavage on pair of basic residues 897 17 1.9 1.1E-01 6.6E-02 > 0.05

FA golgi apparatus 897 32 3.6 1.1E-01 8.3E-02 > 0.05

FA DNA binding 897 20 2.3 1.2E-01 8.2E-02 > 0.05

FA cytoskeleton 897 34 3.8 1.2E-01 8.9E-02 > 0.05

FA meiosis 897 5 0.6 1.3E-01 4.7E-02 > 0.05

FA tyrosine-specific protein kinase 897 5 0.6 1.4E-01 5.0E-02 > 0.05

FA cytokine 897 12 1.4 1.4E-01 8.1E-02 > 0.05

FA phosphotransferase 897 13 1.5 1.4E-01 8.3E-02 > 0.05

FA cytoplasm 897 153 17.2 1.4E-01 1.2E-01 > 0.05

FA mitosis 897 12 1.4 1.5E-01 8.6E-02 > 0.05

FA developmental protein 897 40 4.5 1.5E-01 1.1E-01 > 0.05

FA coiled coil 897 95 10.7 1.5E-01 1.3E-01 > 0.05

FA cyclin 897 5 0.6 1.6E-01 5.8E-02 > 0.05

FA duplication 897 14 1.6 1.6E-01 1.0E-01 > 0.05

FA ubl conjugation 897 31 3.5 1.6E-01 1.2E-01 > 0.05

FA differentiation 897 25 2.8 1.6E-01 1.2E-01 > 0.05

FA transforming protein 897 4 0.5 1.7E-01 5.3E-02 > 0.05

FA metal-binding 897 136 15.3 1.7E-01 1.5E-01 > 0.05

FA cilium 897 6 0.7 1.8E-01 7.8E-02 > 0.05

FA protein phosphatase 897 9 1 1.8E-01 9.8E-02 > 0.05

FA zinc-finger 897 81 9.1 1.8E-01 1.4E-01 > 0.05

FA glycosyltransferase 897 13 1.5 1.9E-01 1.2E-01 > 0.05

FA transmembrane 897 220 24.8 2.1E-01 1.9E-01 > 0.05

FA cell division 897 15 1.7 2.2E-01 1.5E-01 > 0.05

FA myristate 897 8 0.9 2.3E-01 1.3E-01 > 0.05

FA flagellum 897 3 0.3 2.5E-01 7.0E-02 > 0.05

FA integrin 897 4 0.5 2.5E-01 9.2E-02 > 0.05

FA membrane 897 273 30.8 2.5E-01 2.4E-01 > 0.05

FA isopeptide bond 897 17 1.9 2.6E-01 1.9E-01 > 0.05

FA Fatty acid biosynthesis 897 4 0.5 2.7E-01 1.1E-01 > 0.05

FA pharmaceutical 897 4 0.5 2.8E-01 1.1E-01 > 0.05

FA Endonuclease 897 5 0.6 2.8E-01 1.3E-01 > 0.05

FA leucine-rich repeat 897 17 1.9 2.8E-01 2.0E-01 > 0.05

FA nuclease 897 7 0.8 2.9E-01 1.6E-01 > 0.05

FA angiogenesis 897 5 0.6 3.0E-01 1.4E-01 > 0.05

FA metalloprotease 897 9 1 3.0E-01 1.9E-01 > 0.05

FA dna replication 897 6 0.7 3.1E-01 1.7E-01 > 0.05

FA iron 897 15 1.7 3.1E-01 2.2E-01 > 0.05

FA endoplasmic reticulum 897 34 3.8 3.1E-01 2.5E-01 > 0.05

FA glycoprotein 897 189 21.3 3.1E-01 2.8E-01 > 0.05

FA cell adhesion 897 21 2.4 3.2E-01 2.4E-01 > 0.05

FA zinc 897 97 10.9 3.4E-01 3.0E-01 > 0.05

FA Lectin 897 9 1 3.5E-01 2.3E-01 > 0.05

FA mhc ii 897 3 0.3 3.8E-01 1.4E-01 > 0.05

FA cell cycle control 897 3 0.3 3.8E-01 1.4E-01 > 0.05

FA extracellular protein 897 3 0.3 3.8E-01 1.4E-01 > 0.05

FA Endocytosis 897 6 0.7 3.8E-01 2.2E-01 > 0.05

FA cell cycle 897 22 2.5 3.8E-01 3.0E-01 > 0.05

FA coated pit 897 3 0.3 3.9E-01 1.5E-01 > 0.05

FA lipid synthesis 897 6 0.7 3.9E-01 2.3E-01 > 0.05

FA chromosomal rearrangement 897 14 1.6 3.9E-01 2.9E-01 > 0.05

FA proteoglycan 897 4 0.5 4.0E-01 1.9E-01 > 0.05

FA ADP-ribosylation 897 3 0.3 4.1E-01 1.6E-01 > 0.05

FA neurogenesis 897 8 0.9 4.2E-01 2.7E-01 > 0.05

FA Serine protease inhibitor 897 5 0.6 4.3E-01 2.5E-01 > 0.05

FA extracellular matrix 897 12 1.4 4.3E-01 3.2E-01 > 0.05

FA receptor 897 69 7.8 4.3E-01 3.9E-01 > 0.05

FA lysosome 897 8 0.9 4.4E-01 2.9E-01 > 0.05

FA methylation 897 12 1.4 4.4E-01 3.2E-01 > 0.05

FA amino-acid transport 897 3 0.3 4.5E-01 1.9E-01 > 0.05

FA Signal transduction inhibitor 897 3 0.3 4.5E-01 1.9E-01 > 0.05

FA lipid metabolism 897 8 0.9 4.5E-01 3.0E-01 > 0.05

FA manganese 897 8 0.9 4.6E-01 3.1E-01 > 0.05

FA Flavoprotein 897 6 0.7 4.7E-01 2.9E-01 > 0.05

FA immune response 897 11 1.2 4.7E-01 3.4E-01 > 0.05

FA centromere 897 3 0.3 4.8E-01 2.1E-01 > 0.05

FA leucine zipper 897 3 0.3 4.8E-01 2.1E-01 > 0.05

FA motor protein 897 7 0.8 4.8E-01 3.2E-01 > 0.05

FA myristylation 897 3 0.3 4.9E-01 2.2E-01 > 0.05

FA lipid transport 897 4 0.5 4.9E-01 2.6E-01 > 0.05

FA magnesium 897 20 2.3 4.9E-01 3.9E-01 > 0.05

FA signal 897 138 15.6 4.9E-01 4.6E-01 > 0.05

FA zymogen 897 10 1.1 5.0E-01 3.7E-01 > 0.05

FA nuclear pore complex 897 3 0.3 5.1E-01 2.4E-01 > 0.05

FA actin binding 897 3 0.3 5.1E-01 2.4E-01 > 0.05

FA alternative initiation 897 4 0.5 5.1E-01 2.8E-01 > 0.05

FA microtubule 897 11 1.2 5.1E-01 3.8E-01 > 0.05

FA surface antigen 897 3 0.3 5.3E-01 2.6E-01 > 0.05

FA phospholipid biosynthesis 897 3 0.3 5.3E-01 2.6E-01 > 0.05

FA dioxygenase 897 4 0.5 5.3E-01 3.0E-01 > 0.05

FA FAD 897 6 0.7 5.3E-01 3.5E-01 > 0.05

FA lipoprotein 897 28 3.2 5.3E-01 4.3E-01 > 0.05

FA blocked amino end 897 5 0.6 5.4E-01 3.5E-01 > 0.05

FA hydrolase 897 66 7.4 5.4E-01 5.1E-01 > 0.05

FA antibiotic 897 4 0.5 5.5E-01 3.2E-01 > 0.05

FA lyase 897 6 0.7 5.6E-01 3.8E-01 > 0.05

FA calmodulin-binding 897 6 0.7 5.7E-01 3.9E-01 > 0.05

FA Antimicrobial 897 4 0.5 5.8E-01 3.5E-01 > 0.05

FA heme 897 6 0.7 5.8E-01 4.0E-01 > 0.05

FA disulfide bond 897 122 13.8 5.9E-01 5.5E-01 > 0.05

FA steroid metabolism 897 3 0.3 6.0E-01 3.3E-01 > 0.05

FA metalloprotein 897 6 0.7 6.0E-01 4.2E-01 > 0.05

FA translocation 897 4 0.5 6.1E-01 3.8E-01 > 0.05

FA gpi-anchor 897 6 0.7 6.1E-01 4.4E-01 > 0.05

FA potassium 897 6 0.7 6.1E-01 4.4E-01 > 0.05

FA transmembrane protein 897 27 3 6.1E-01 5.3E-01 > 0.05

FA Secreted 897 70 7.9 6.2E-01 5.7E-01 > 0.05

FA cataract 897 3 0.3 6.3E-01 3.5E-01 > 0.05

FA Monooxygenase 897 4 0.5 6.4E-01 4.2E-01 > 0.05

FA nadp 897 7 0.8 6.4E-01 4.9E-01 > 0.05

FA prenylation 897 7 0.8 6.4E-01 4.9E-01 > 0.05

FA cell projection 897 9 1 6.4E-01 5.0E-01 > 0.05

FA microsome 897 5 0.6 6.6E-01 4.6E-01 > 0.05

FA protease inhibitor 897 5 0.6 6.6E-01 4.7E-01 > 0.05

FA host-virus interaction 897 12 1.4 6.6E-01 5.4E-01 > 0.05

FA oxidoreductase 897 23 2.6 6.6E-01 5.8E-01 > 0.05

FA chromatin regulator 897 9 1 6.8E-01 5.4E-01 > 0.05

FA ank repeat 897 10 1.1 6.8E-01 5.6E-01 > 0.05

FA Immunoglobulin domain 897 19 2.1 6.9E-01 6.0E-01 > 0.05

FA calcium transport 897 4 0.5 7.0E-01 4.8E-01 > 0.05

FA acetylation 897 107 12.1 7.0E-01 6.7E-01 > 0.05

FA actin-binding 897 10 1.1 7.1E-01 5.9E-01 > 0.05

FA EF hand 897 3 0.3 7.2E-01 4.7E-01 > 0.05

FA potassium transport 897 5 0.6 7.2E-01 5.3E-01 > 0.05

FA P-loop 897 5 0.6 7.2E-01 5.4E-01 > 0.05

FA calcium channel 897 3 0.3 7.3E-01 4.8E-01 > 0.05

FA sh3-binding 897 3 0.3 7.3E-01 4.8E-01 > 0.05

FA peroxisome 897 4 0.5 7.3E-01 5.3E-01 > 0.05

FA chromosomal protein 897 6 0.7 7.3E-01 5.7E-01 > 0.05

FA Antiviral defense 897 3 0.3 7.4E-01 4.9E-01 > 0.05

FA pyridoxal phosphate 897 3 0.3 7.4E-01 4.9E-01 > 0.05

FA fatty acid metabolism 897 3 0.3 7.4E-01 4.9E-01 > 0.05

FA lipid-binding 897 4 0.5 7.4E-01 5.4E-01 > 0.05

FA methyltransferase 897 6 0.7 7.4E-01 5.8E-01 > 0.05

FA Protease 897 19 2.1 7.4E-01 6.5E-01 > 0.05

FA Isomerase 897 5 0.6 7.5E-01 5.7E-01 > 0.05

FA heparin-binding 897 3 0.3 7.6E-01 5.2E-01 > 0.05

FA mental retardation 897 3 0.3 7.8E-01 5.4E-01 > 0.05

FA GTP binding 897 3 0.3 7.8E-01 5.4E-01 > 0.05

FA Acyltransferase 897 6 0.7 7.8E-01 6.3E-01 > 0.05

FA palmitate 897 8 0.9 8.0E-01 6.8E-01 > 0.05

FA LIM domain 897 3 0.3 8.1E-01 5.8E-01 > 0.05

FA kelch repeat 897 3 0.3 8.1E-01 5.8E-01 > 0.05

FA chemotaxis 897 3 0.3 8.1E-01 5.9E-01 > 0.05

FA mRNA transport 897 3 0.3 8.2E-01 6.1E-01 > 0.05

FA dna repair 897 7 0.8 8.2E-01 7.0E-01 > 0.05

FA nucleotidyltransferase 897 3 0.3 8.3E-01 6.3E-01 > 0.05

FA nucleotide binding 897 4 0.5 8.3E-01 6.6E-01 > 0.05

FA inflammatory response 897 3 0.3 8.4E-01 6.3E-01 > 0.05

FA membrane protein 897 3 0.3 8.4E-01 6.3E-01 > 0.05

FA potassium channel 897 3 0.3 8.5E-01 6.4E-01 > 0.05

FA innate immunity 897 3 0.3 8.5E-01 6.4E-01 > 0.05

FA Symport 897 4 0.5 8.5E-01 6.9E-01 > 0.05

FA ubl conjugation pathway 897 18 2 8.6E-01 8.1E-01 > 0.05

FA spermatogenesis 897 4 0.5 8.7E-01 7.2E-01 > 0.05

FA G protein-coupled receptor 897 4 0.5 8.7E-01 7.2E-01 > 0.05

FA DNA damage 897 7 0.8 8.7E-01 7.6E-01 > 0.05

FA calcium 897 29 3.3 8.7E-01 8.3E-01 > 0.05

FA voltage-gated channel 897 5 0.6 8.8E-01 7.6E-01 > 0.05

FA Apoptosis 897 13 1.5 8.8E-01 8.2E-01 > 0.05

FA hormone 897 3 0.3 8.9E-01 7.1E-01 > 0.05

FA homodimer 897 3 0.3 8.9E-01 7.3E-01 > 0.05

FA guanine-nucleotide releasing factor 897 4 0.5 8.9E-01 7.5E-01 > 0.05

FA zinc finger 897 5 0.6 8.9E-01 7.8E-01 > 0.05

FA thiol protease 897 4 0.5 9.0E-01 7.8E-01 > 0.05

FA ribosomal protein 897 6 0.7 9.0E-01 8.1E-01 > 0.05

FA mitochondrion inner membrane 897 6 0.7 9.1E-01 8.3E-01 > 0.05

FA acetylated amino end 897 3 0.3 9.3E-01 8.0E-01 > 0.05

FA deafness 897 3 0.3 9.3E-01 8.0E-01 > 0.05

FA calcium binding 897 3 0.3 9.3E-01 8.1E-01 > 0.05

FA Serine protease 897 4 0.5 9.3E-01 8.3E-01 > 0.05

FA tumor suppressor 897 4 0.5 9.3E-01 8.3E-01 > 0.05

FA transducer 897 30 3.4 9.3E-01 9.0E-01 > 0.05

FA ligase 897 9 1 9.5E-01 9.0E-01 > 0.05

FA wd repeat 897 8 0.9 9.5E-01 9.0E-01 > 0.05

FA Chaperone 897 4 0.5 9.6E-01 9.0E-01 > 0.05

FA g-protein coupled receptor 897 26 2.9 9.6E-01 9.5E-01 > 0.05

FA transit peptide 897 14 1.6 9.7E-01 9.4E-01 > 0.05

FA cytoplasmic vesicle 897 6 0.7 9.7E-01 9.4E-01 > 0.05

FA protein transport 897 14 1.6 9.7E-01 9.5E-01 > 0.05

FA cell junction 897 11 1.2 9.7E-01 9.5E-01 > 0.05

FA cell membrane 897 77 8.7 9.7E-01 9.7E-01 > 0.05

FA helicase 897 3 0.3 9.8E-01 9.2E-01 > 0.05

FA endosome 897 5 0.6 9.8E-01 9.4E-01 > 0.05

FA vision 897 3 0.3 9.8E-01 9.4E-01 > 0.05

FA ribonucleoprotein 897 7 0.8 9.8E-01 9.5E-01 > 0.05

FA ionic channel 897 8 0.9 9.8E-01 9.6E-01 > 0.05

FA rna-binding 897 14 1.6 9.9E-01 9.8E-01 > 0.05

FA mrna splicing 897 4 0.5 9.9E-01 9.8E-01 > 0.05

FA mrna processing 897 5 0.6 1.0E+00 9.9E-01 > 0.05

FA disease mutation 897 49 5.5 1.0E+00 9.9E-01 > 0.05

FA protein biosynthesis 897 3 0.3 1.0E+00 9.9E-01 > 0.05

FA synapse 897 3 0.3 1.0E+00 9.9E-01 > 0.05

FA ion transport 897 13 1.5 1.0E+00 1.0E+00 > 0.05

FA transport 897 49 5.5 1.0E+00 1.0E+00 > 0.05

FA mitochondrion 897 18 2 1.0E+00 1.0E+00 > 0.05

FA olfaction 897 6 0.7 1.0E+00 1.0E+00 > 0.05

FA sensory transduction 897 10 1.1 1.0E+00 1.0E+00 > 0.05